JPH1180795A - Detergent for contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject contact lens detergent that can cleanse eye discharge and the like sticking to contact lenses after long-term application, can do suitable lens care and can be conveniently and safely used by using a combination of a protease, a nonionic surfactant and a sulfurous salt. SOLUTION: This contact lens detergent contains (A) a protease as originating from Penicillium, (B) a nonionic surfactant and (C) a sulfurous salt and, in a preferred embodiment, the content of the component A is 0.1-10 wt.%, the component B is 1-30 wt. % and the component C is 1-30 wt.%. The component B is preferably solid at ambient temperature, particularly polyethylene glycol fatty acid ester and/or polyoxyethylene-oxypropylene block copolymer are preferred. The component C is preferably selected from sodium sulfite and/or sodium hydrogen sulfite. The objective detergent is prepared in the form of usual powder or granules or other solid forms and it is dissolved in water or physiological salt solution before it is used.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cleaning agent for hard contact lenses and soft contact lenses.

[0002]

2. Description of the Related Art A contact lens includes a hard contact lens whose main component is methyl methacrylate;
-Soft contact lenses made of hydroxyethyl methacrylate are widely used, but these lenses gradually become stained with proteins, lipids, cosmetics, dust, etc. May cause disability. Conventionally, lens cleaning includes a method of rubbing and removing dirt attached to the lens with a cleaning agent containing a surfactant as a main component, or a method of emulsifying and dispersing by immersion cleaning. Alternatively, a method of rubbing and cleaning with a detergent containing an abrasive, and a dip-washing method using an enzyme such as a proteolytic enzyme or a lipolytic enzyme have also been widely used, and their usefulness has been confirmed.

[0003] All of these detergents and preservatives are
It is useful for removing dirt from contact lenses, and it can be expected that proper lens management will be performed by using them.

[0004]

However, even if the contact lenses are cleaned every day, especially those who tend to get dirty will gradually become dirty over a long period of time. Such fixed dirt is difficult to remove even by washing with a normal surfactant or immersion washing using an enzyme. In such a case, a method of rubbing and washing with a detergent containing an abrasive is mainly used. Used.

However, some hard contact lenses have been subjected to a surface treatment in order to improve the water wettability of the lens surface. When the surface-treated lens is rubbed and cleaned with a cleaning agent containing an abrasive, Although the fixed dirt is removed, the effect of the surface treatment of the lens is weakened, the wettability is deteriorated, and the original function of the lens is reduced. Further, in the case of a soft contact lens, the abrasive tends to remain, and if the soft contact lens is worn with the abrasive adhered, the cornea may be damaged and the eye may be damaged. In addition, a hard contact lens detergent containing an oxidizing bleach component such as hypochlorous acid is also commercially available, but it cannot be expected to remove much soil in a short time, and if soaked for a long time, Bleaching up to the stain of the lens causes decolorization of the lens. Also, it cannot be used for soft contact lenses from the viewpoint of safety. Foamed tablet-type enzyme detergents that remove stuck stains are also available on the market, but they do not have sufficient detergency and require long soaking of the lens to completely remove stuck stains. It was not very good.

Accordingly, the present invention has been achieved by intensive studies with the object of solving these problems. That is, an object of the present invention is to provide a soft contact lens and a hard lens which can wash dirt fixed on a contact lens by a long-term use in a short period of time, provide appropriate contact lens care, and can be used more conveniently and safely for a user. It is to provide a cleaning agent for contact lenses.

[0007]

Means for Solving the Problems The present inventors have found that the object can be achieved by using a combination of a proteolytic enzyme, a nonionic surfactant and a sulfite.

[0008] That is, the cleaning agent for contact lenses according to claim 1 is characterized by containing a protease, a nonionic surfactant and a sulfite.

The contact lens cleaning agent according to claim 2 is the contact lens cleaning agent according to claim 1, wherein the content of each of the components is 0.1 to 10% by weight of the protease, and the nonionic interface. 1 to 30% by weight of an activator and 1 to 30% by weight of a sulfite.

[0010] In a third aspect of the present invention, there is provided a contact lens cleaning agent according to the first or second aspect, wherein the nonionic surfactant is solid at room temperature.

The contact lens cleaning agent according to claim 4 is the contact lens cleaning agent according to any one of claims 1 to 3, wherein the nonionic surfactant is:
It is a polyethylene glycol fatty acid ester and / or a polyoxyethylene oxypropylene block polymer.

According to a fifth aspect of the present invention, in the contact lens cleaning agent according to any one of the first to fourth aspects, the sulfite is sodium sulfite and / or sodium hydrogen sulfite. It is characterized by.

[0013] The protease used in the present invention includes:
Those derived from microorganisms include, for example, penicillium-derived protease and Bacillus-derived protease.
The amount of the enzyme is preferably 0.1 to 10% by weight. If it is 0.1% or less, a sufficient cleaning effect cannot be expected, and even if 10% or more is added, no remarkable increase in the cleaning effect is observed.

The nonionic surfactant used in the present invention is a solid at room temperature, and is a polyethylene glycol fatty acid ester and / or a polyoxyethylene oxypropylene block polymer, all of which are commercially available. The amount of the nonionic surfactant is preferably from 1 to 30% by weight. When the content is 1% or less, a sufficient cleaning effect cannot be expected, and even when 30% or more is added, no remarkable increase in the cleaning effect is observed.

The sulfite used in the present invention is sodium sulfite and / or sodium bisulfite, and the amount of the sulfite is 1 to 30% by weight. When the content is 1% or less, a sufficient cleaning effect cannot be expected, and even when 30% or more is added, no remarkable increase in the cleaning effect is observed.

The contact lens cleaning agent according to the present invention is capable of cleaning dirt adhered to a contact lens in a short time, enabling proper contact lens care, and being more convenient and safe for users to use. Agent. Usually, it is formed into a solid form such as powder, granules, tablets and the like, and is used by dissolving it in a liquid such as water, physiological saline, a diluent for contact lenses, a preservation solution or the like at the time of use.

The cleaning agent of the present invention can contain conventionally known components in addition to these components. That is, a metal chelating agent such as EDTA-2Na or citric acid, which can chelate and remove metal ions such as calcium ions and iron ions adhered to the contact lens to fix dirt, has the same liquid properties as tears. PH buffers such as phosphoric acid and its salts, boric acid and its salts, inorganic salts such as sodium chloride and potassium chloride to maintain the same osmotic pressure as tears, and benzalkonium chloride to prevent microbial contamination And antiseptic and bactericides such as sorbic acid and the like.

[0018]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described specifically with reference to examples, but the present invention is not limited to these examples. The method of preparing the contact lens with artificial stains used in the evaluation of the detergency in the examples and the evaluation criteria for the detergency were carried out by the following methods.

<Method of preparing contact lens with artificial stain> 0.4 g of bovine serum albumin, 0.2 g of bovine serum gamma globulin, 0.2 g of egg lysozyme, 0.05 g of swine stomach-derived mucin are suspended in 100 ml of physiological saline. After dissolving, the insoluble matter was filtered with filter paper (TOYO No. 1). 25 ml of this stain solution (protein stain solution) in a 200 ml beaker
The contact lens was immersed and denatured and adhered at 65 ° C. for 30 minutes, and dried at 50 ° C. for 30 minutes. Furthermore, tripalmitin 0.05g, palmitic acid 0.05g,
Cetyl alcohol 0.05 g, cholesterol 0.05
g, lecithin 0.05 g, oleic acid 0.1 g, lino-
0.1 g of luic acid was placed in 30 ml of ethanol and dissolved by heating, and this stain solution (lipid stain solution) was applied to the surface of the lens and dried at 50 ° C. for 30 minutes. This series of operations was repeated three times to produce an artificially soiled contact lens in which protein and lipid were adhered white on the entire surface of the contact lens.

<Evaluation Criteria for Detergency>-There is no clouding of the lens ± The lens is slightly clouded + The clouding of the lens is 20% or more of the whole +++ The clouding of the lens is 50% or more of the whole +++ The entire surface of the lens is clouded (Examples 1 to 9) Contact lens cleaners (powder or granules, tablets) having the formulations shown in Table 1 were prepared. In addition, about a tablet, after mixing each component uniformly, it shape | molded into the tablet of 6 mm in diameter with the tableting pressure of 600 kg.

Next, one package or one tablet of this contact lens cleaning agent was dissolved in a dissolving solution (2.5 ml) shown in Table 2,
The contact lens to which dirt was artificially attached was immersed therein, and after 1, 2, 4, and 8 hours, the degree of dirt removal of each lens was visually determined. Table 2 shows the results. The color and shape of the lens did not change.

[0022]

[Table 1]

[0023]

[Table 2]

Comparative Examples 1 to 3 Contact lens detergents (tablets) having the formulations shown in Table 3 were prepared. In addition, after mixing each component uniformly, it was formed into a tablet having a diameter of 6 mm with a tableting pressure of 600 kg. Then, one tablet of this contact lens detergent was dissolved in a dissolving solution (2.5 ml) shown in Table 2, and a contact lens having artificially adhered dirt was immersed therein, and after 1, 2, 4, and 8 hours, The degree of dirt removal of the lens was visually determined. Table 2 shows the results. The color and shape of the lens did not change.

[0025]

[Table 3]

From the results shown in Table 2, it was confirmed that the product of the present invention can remove artificially adhered dirt in a short time. The test was also performed on a soiled contact lens which had been used for 6 months. Table 4 shows the results. The color and shape of the lens did not change.

[0027]

[Table 4]

From the results shown in Table 4, it was confirmed that the product of the present invention can remove dirt attached to the contact lens in a short time.

[0029]

According to the contact lens cleaning agent of the present invention, dirt adhered to a contact lens can be cleaned in a short time, and proper contact lens care can be performed.
It has the effect of being more convenient and safer to use.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI C11D 3: 386 3:04)

Claims (5)

[Claims] 1. A cleaning agent for contact lenses, comprising a protease, a nonionic surfactant and a sulfite. 2. The cleaning agent for contact lenses according to claim 1, wherein the content of each of the components is 0.1 to 0.1%.
A cleaning agent for contact lenses, comprising 10% by weight, 1 to 30% by weight of a nonionic surfactant and 1 to 30% by weight of a sulfite. 3. The cleaning agent for contact lenses according to claim 1, wherein the nonionic surfactant is solid at room temperature. 4. The cleaning agent for contact lenses according to claim 1, wherein the nonionic surfactant is a polyethylene glycol fatty acid ester and / or a polyoxyethylene oxypropylene block polymer. A cleaning agent for contact lenses, comprising: 5. The cleaning agent for a contact lens according to claim 1, wherein the sulfite is sodium sulfite and / or sodium hydrogen sulfite.