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JPH11299903A - Embedded-in-body chemical administering device - Google Patents

Embedded-in-body chemical administering device

Info

Publication number
JPH11299903A
JPH11299903A JP10124237A JP12423798A JPH11299903A JP H11299903 A JPH11299903 A JP H11299903A JP 10124237 A JP10124237 A JP 10124237A JP 12423798 A JP12423798 A JP 12423798A JP H11299903 A JPH11299903 A JP H11299903A
Authority
JP
Japan
Prior art keywords
region
drug solution
solution
administration device
injected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10124237A
Other languages
Japanese (ja)
Inventor
Takashi Mikami
隆 三上
Yoshihiro Urade
良博 裏出
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIO TEX KK
Original Assignee
BIO TEX KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIO TEX KK filed Critical BIO TEX KK
Priority to JP10124237A priority Critical patent/JPH11299903A/en
Publication of JPH11299903A publication Critical patent/JPH11299903A/en
Pending legal-status Critical Current

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  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROBLEM TO BE SOLVED: To control a dose, while minimizing physical and metal burden on an animal to be examined, when an examiner administers the body of the animal to be examined. SOLUTION: An embedded-in-body chemical administering device comprises a container 1 having a first region 2 in which a chemical is injected and a second region 3 adjacent to the first region 2 spaced via an elastic membrane 9, the second region 3 being provided with a pair of electrodes 6, 6' and the second region 3 having electrolytic solution injected therein so that the electrolytic solution is electrolyzed to generate a gas for pushing up the elastic membrane 9, when a voltage is applied between the electrodes 6, 6', whereby a chemical is released out of a release hole 4 provided in the first region 2. The release hole 4 has a guide tube 10 for guiding the released chemical to a predetermined location.

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【0001】[0001]

【発明の属する技術分野】本発明は、薬液の投与量や投
与のタイミングをコントロールできる体内埋込型薬液投
与装置に関する。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an implantable drug solution administration device capable of controlling the dose and timing of administration of a drug solution.

【0002】[0002]

【従来の技術】例えばマウスやラットなどを用いた動物
実験において、注射器を使用して薬液が投与される場合
がある。しかしながら、注射器で薬液を投与する際に
は、被実験動物に瞬間的に特別のストレスを与えること
となり、かかる条件下では、必ずしも投与薬液の薬効の
みに依存する実験データを得ることは困難である。そこ
で、従来より、被実験動物の体内に予め埋め込んでおい
て、投与量や投与のタイミングを制御しつつ所望の薬液
を投与できる体内埋込型薬液投与装置が存在した。この
ような体内埋込型薬液投与装置には、被実験動物の肉体
的および精神的負担を軽減すべく、小型化することが要
求されていることに加えて、実験者が投与量や投与のタ
イミング等を自由にコントロールできることが要求され
ている。このような体内埋込型投薬装置として、例えば
電動式アクチュエーターを使用した装置が考えられる
が、これは装置の小型化が困難であり、また構成が複雑
であり耐久性に乏しく、しかも高コストとなる。一方、
例えばALZET社より市販されているALZET(登
録商標)のように、浸透圧を利用した薬液投与ポンプが
存在するが、これは小型ではあるが、実験者が投与量や
投与のタイミングをコントロールできない。
2. Description of the Related Art In an animal experiment using, for example, a mouse or a rat, a drug solution may be administered using a syringe. However, when a medicinal solution is administered with a syringe, a special stress is instantaneously applied to the test animal, and under such conditions, it is difficult to obtain experimental data that depends only on the medicinal effect of the administered medicinal solution. . Therefore, conventionally, there has been an implantable drug solution administration device which can be implanted in the body of a test animal in advance and can administer a desired drug solution while controlling the dose and the timing of administration. In order to reduce the physical and mental burden on the animal under test, such implantable drug solution administration devices are required to be miniaturized. It is required that timing and the like can be freely controlled. As such an implantable medication device, for example, a device using an electric actuator is conceivable, but it is difficult to reduce the size of the device, the configuration is complicated, the durability is poor, and the cost is high. Become. on the other hand,
For example, there is a drug solution administration pump utilizing osmotic pressure, such as ALZET (registered trademark) marketed by ALZET, which is small in size, but does not allow an experimenter to control the dose and the timing of administration.

【0003】[0003]

【発明が解決しようとする課題】そこで、本発明は、実
験者が被実験動物の体内に投与するに際して、被実験動
物の肉体的および精神的負担を最小限に抑制しつつ投与
量および投与のタイミングを自由にコントロールできる
体内埋込型薬液投与装置を提供することを課題とする。
SUMMARY OF THE INVENTION Accordingly, the present invention provides a method and a method for administering to a subject an animal while minimizing the physical and mental burden on the subject. An object of the present invention is to provide an implantable drug solution administration device capable of freely controlling timing.

【0004】[0004]

【課題を解決するための手段】本願発明者は上記課題を
解決すべく種々検討を重ねた結果、内部に薬液が注入さ
れる第一領域と、前記第一領域と弾性膜を隔てて隣接す
る第二領域とを備えた容器から成る体内埋込型薬液投与
装置であって、前記第二領域は一対の電極を備えている
とともに前記第二領域には電解質溶液が注入されてお
り、前記電極間に電圧を加えると前記電解質溶液が電気
分解されて気体を発生して前記弾性膜を押し上げて、こ
れによって前記薬液が前記第一領域に設けられた放出孔
から放出されることを特徴とする薬液投与装置とするこ
とにより上記課題は解決されることを見いだした。ま
た、本発明の更なる実施形態においては、前記放出孔に
は、放出された前記薬液を所定の場所まで誘導するため
の誘導管が取り付けられている。以下本発明を詳細に説
明する。
The inventor of the present invention has conducted various studies to solve the above-mentioned problems. As a result, the first region into which the chemical solution is injected is adjacent to the first region with the elastic film interposed therebetween. An implantable drug solution administration device comprising a container having a second region, wherein the second region has a pair of electrodes and an electrolyte solution is injected into the second region, and the electrode When a voltage is applied in between, the electrolyte solution is electrolyzed to generate gas and push up the elastic membrane, whereby the chemical solution is discharged from a discharge hole provided in the first region. It has been found that the above problem can be solved by using a drug solution administration device. Further, in a further embodiment of the present invention, a guide tube for guiding the discharged drug solution to a predetermined location is attached to the discharge hole. Hereinafter, the present invention will be described in detail.

【0005】本発明において、第一領域と第二領域とを
備えた容器を構成する材料は、生態適合性を有する材料
であれば特に限定されないが、通常ポリプロピレン等の
プラスチック製容器が使用される。容器の寸法は特に限
定されず、被実験動物の大きさ、投与する薬液の量、実
験期間等を考慮して任意に設計できる。
In the present invention, the material constituting the container having the first region and the second region is not particularly limited as long as it is a material having biocompatibility, but a plastic container such as polypropylene is usually used. . The size of the container is not particularly limited, and can be arbitrarily designed in consideration of the size of the test animal, the amount of the drug solution to be administered, the experimental period, and the like.

【0006】容器の内部は、第一領域と第二領域に仕切
られている。第一領域は、被実験動物に投与するための
薬液が注入される部屋であり、第一領域から薬液を放出
するための放出孔を少なくとも1個有している。好まし
くは、この放出孔は、放出された薬液を被実験動物の所
定の血管内や器官等に誘導するための誘導管を備えてい
る。通常、薬液は放出孔から注入されるが、別途薬液を
注入するための孔を設けてもよい。第二領域は、電解質
溶液の電気分解を利用して、第一領域内に注入された薬
液をコントロールしながら放出するための部屋である。
従って、第二領域には電解質溶液が注入されており、さ
らに少なくとも2個(一対)の電極が第二領域内に突き
出すように設置されている。また、好ましくは、電解質
溶液を注入した後に封止できる電解質溶液注入孔を少な
くとも1個有している。なお、本発明の薬液投与装置
は、第一領域と第二領域をそれぞれ少なくとも1個有し
ているが、例えば2種類以上の薬液を投与する場合に
は、第一領域および/または第二領域を2個以上設けて
もよい。
[0006] The interior of the container is partitioned into a first area and a second area. The first region is a room into which a drug solution to be administered to a test animal is injected, and has at least one release hole for releasing the drug solution from the first region. Preferably, the release hole is provided with a guide tube for guiding the released drug solution into a predetermined blood vessel, organ, or the like of the test animal. Usually, the liquid medicine is injected from the release hole, but a hole for separately injecting the liquid medicine may be provided. The second region is a room for controlling and releasing the chemical solution injected into the first region using the electrolysis of the electrolyte solution.
Therefore, the electrolyte solution is injected into the second region, and at least two (one pair) electrodes are provided so as to protrude into the second region. Further, it is preferable to have at least one electrolyte solution injection hole that can be sealed after the injection of the electrolyte solution. In addition, although the chemical | medical-solution administration apparatus of this invention has at least 1 each of a 1st area | region and a 2nd area | region, when administering 2 or more types of chemicals, for example, the 1st area | region and / or the 2nd area | region May be provided two or more.

【0007】第一領域および第二領域の内容積は被実験
動物の寸法や実験期間等を考慮して任意に設計できる
が、被実験動物がマウスやウサギなどの小型動物である
場合、第一領域の内容積は1μl〜10ml、好ましく
は10μl〜1000μl、さらに好ましくは100μ
l〜1000μlであり、第二領域の内容積は1μl〜
10ml、好ましくは10μl〜1000μl、さらに
好ましくは300μl〜1000μlである。
[0007] The internal volumes of the first region and the second region can be arbitrarily designed in consideration of the size of the test animal, the experimental period, and the like. The inner volume of the region is 1 μl to 10 ml, preferably 10 μl to 1000 μl, more preferably 100 μl.
1 to 1000 μl, and the internal volume of the second region is 1 μl to
The volume is 10 ml, preferably 10 μl to 1000 μl, more preferably 300 μl to 1000 μl.

【0008】本発明において、第一領域と第二領域とに
仕切る弾性膜には少なくとも次の特性が要求される。即
ち、第二領域内で気体が発生して弾性膜を押し上げて
も、亀裂等の損傷が生じないことであり、しかも使用環
境において腐食等の望ましくない化学変化を起こさない
ことが要求され、さらに気体透過性ができるだけ低い材
料から構成されていることが好ましい。本発明に有用な
弾性膜としては、例えば、アクリル系ポリマー、シリコ
ン系ポリマー等からなる弾性を有する膜が挙げられる。
In the present invention, at least the following characteristics are required for the elastic film partitioning into the first region and the second region. That is, even if gas is generated in the second region and the elastic film is pushed up, damage such as cracks does not occur, and it is required that undesired chemical changes such as corrosion do not occur in a use environment. It is preferable to be made of a material having a gas permeability as low as possible. Examples of the elastic film useful in the present invention include an elastic film made of an acrylic polymer, a silicon polymer, or the like.

【0009】本発明において、第二領域内に注入される
電解質溶液には少なくとも次の特性が要求される。即
ち、実用的なレベルの通電量で電気分解を起こして気体
を発生することが要求される。従って、本発明に有用な
電解質溶液としては、例えば生理食塩水、希硫酸溶液、
希塩酸溶液等の 0.001〜5mol/l、好ましく
は0.1〜3mol/l溶液であることが好ましい。
In the present invention, at least the following characteristics are required for the electrolyte solution injected into the second region. That is, it is required to generate gas by causing electrolysis at a practical level of electricity supply. Therefore, as the electrolyte solution useful in the present invention, for example, physiological saline, dilute sulfuric acid solution,
It is preferably a 0.001 to 5 mol / l, preferably 0.1 to 3 mol / l solution of a dilute hydrochloric acid solution or the like.

【0010】本発明において、第二領域内に設けられた
電極は、例えば容器の外部に設けられた端子に電気的に
接続されており、この端子には、実験者が所望のタイミ
ングで所望の電力を供給できる電力供給手段が接続され
ている。このような電力供給手段としては、例えば次の
ような方法が考えられるが、これらに限定される訳では
ない。一つには、体内に埋め込んだ薬液投与装置に接続
された電力供給用ケーブルの一端部を体外まで引き出し
て、このケーブルから電力を供給する有線電力供給方式
が考えられる。また、図2に示すように、薬液投与装置
への電力の供給を制御するための送信装置と、本発明の
薬液投与装置とともに被実験動物の体内に埋め込まれ、
前記送信装置からの信号を受けて内蔵の電池から薬液投
与装置に電力を供給する受信装置とから成る従来周知の
テレメトリー方式が考えられる。さらに、図3に示すよ
うに、体外のコイルからの高周波の電磁波を受けて体内
のコイル上に交流電力を発生させ、これを整流装置にて
直流電力に変換して薬液投与装置に供給する電磁誘導型
電力供給方式が考えられる。なお、電気分解で発生する
気体の量は、一般的に通電量に依存するため、予め通電
量に対する気体発生量の関係を求めておくことにより、
通電量を制御することによって放出薬液量を任意に制御
できる。
In the present invention, the electrode provided in the second region is electrically connected to, for example, a terminal provided outside the container, and the terminal is connected to a desired terminal at a desired timing by an experimenter. Power supply means capable of supplying power is connected. As such power supply means, for example, the following methods are conceivable, but are not limited thereto. For example, a wired power supply system in which one end of a power supply cable connected to a drug solution administration device embedded in a body is pulled out of the body and power is supplied from the cable may be considered. Further, as shown in FIG. 2, a transmitting device for controlling the supply of electric power to the drug solution administration device and the drug solution administration device of the present invention are implanted in the body of the test animal together with
A conventionally well-known telemetry system including a receiving device that receives a signal from the transmitting device and supplies power from a built-in battery to the drug solution administration device can be considered. Further, as shown in FIG. 3, an AC power is generated on the coil inside the body in response to a high-frequency electromagnetic wave from a coil outside the body, and the AC power is converted into DC power by a rectifier to be supplied to a drug administration device. An inductive power supply system is conceivable. In addition, since the amount of gas generated by electrolysis generally depends on the amount of electricity, by obtaining the relationship between the amount of gas generation and the amount of electricity in advance,
By controlling the amount of electricity, the amount of the released chemical solution can be arbitrarily controlled.

【0011】[0011]

【発明の実施の形態】以下に、本発明を実施例に基づい
てさらに詳細に説明する。図1は、本発明の1実施例に
よる体内埋込型薬液投与装置を示す概略図である。この
薬液投与装置を構成する容器1は、外形寸法が約0.5
cm×2cm×2cmのポリプロプレン製である。弾性
膜9としては、厚さは約0.1mmのものを使用した。第
一領域2の内容積は250μlであり、上部に設けられ
た放出孔4から内部に所定の投薬液を注入した。この放
出孔4には、放出された薬液を被実験動物の所定の器官
まで誘導するための誘導管10が取り付けられている。
第二領域3の内容積は、870μlであり、電解質溶液
注入孔5から注入した後、この孔5は封止した。本実施
例においては、電解質溶液として、約0.34mol/
l(約2重量%)の生理食塩水を使用した。また、対向
する第二領域内壁には一対の電極7、7’が設置されて
いる。この電極は金メッキを施したステレス鋼製のもの
であり、容器外部の端子6、6’に電気的に接続されて
いる。そしてこの端子6、6’は、電源装置8に接続さ
れるようになっている。電源装置8は本発明の薬液投与
装置とともに被実験動物の体内に埋め込まれ、この電源
装置8に組み込まれた受信装置13と共働する送信装置
14を実験者が操作することにより、被実験動物に薬液
を投与することができる。上記のように構成した本実施
例の薬液投与装置をラットの体内に埋め込んで使用した
場合、コントロール装置を操作して第二領域内の電極間
に1mAの電流を流すと、10μl/minの速度で薬
液を投与することができる。
DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in more detail based on embodiments. FIG. 1 is a schematic view showing an implantable drug solution administration device according to one embodiment of the present invention. The container 1 constituting this medicinal-solution administration device has an outer dimension of about 0.5
cm × 2 cm × 2 cm made of polypropylene. The elastic film 9 used had a thickness of about 0.1 mm. The internal volume of the first region 2 was 250 μl, and a predetermined drug solution was injected into the inside from the discharge hole 4 provided in the upper part. A guide tube 10 for guiding the released drug solution to a predetermined organ of the test animal is attached to the release hole 4.
The internal volume of the second region 3 was 870 μl, and after the electrolyte solution was injected from the injection hole 5, the hole 5 was sealed. In the present embodiment, about 0.34 mol /
1 (about 2% by weight) of physiological saline was used. In addition, a pair of electrodes 7 and 7 ′ are provided on the inner wall of the opposing second region. The electrode is made of gold-plated stainless steel and is electrically connected to terminals 6, 6 'outside the container. The terminals 6 and 6 ′ are connected to a power supply 8. The power supply device 8 is embedded in the body of the animal under test together with the drug solution administration device of the present invention, and the experimenter operates the transmitting device 14 that cooperates with the receiving device 13 incorporated in the power supply device 8 so that the animal Can be administered with a drug solution. When the drug administration device of the present embodiment configured as described above is used by being implanted in the body of a rat, when a control device is operated and a current of 1 mA flows between the electrodes in the second region, the speed is 10 μl / min. Can be used to administer the drug solution.

【0012】[0012]

【発明の効果】本発明による体内埋込型薬液投与装置
は、外部からの操作により、所望時に所望量の薬液を投
与することができる。また、この薬液投与装置は単純な
構成であるため、長期間安定に使用することができる。
さらに、この薬液投与装置の寸法は被実験動物の寸法に
合わせて任意に設計できる。従って本発明の薬液投与装
置を使用すると、薬液投与時における被実験動物への肉
体的および精神的苦痛が抑制されるため、薬効について
正確な実験データを得ることができる。
The implantable drug solution administration device according to the present invention can administer a desired amount of drug solution when desired by an external operation. Further, since the liquid medicine administration device has a simple configuration, it can be stably used for a long period of time.
Further, the size of the drug solution administration device can be arbitrarily designed in accordance with the size of the test animal. Therefore, when the drug solution administration device of the present invention is used, physical and mental distress to an experimental animal at the time of drug solution administration is suppressed, so that accurate experimental data on drug efficacy can be obtained.

【図面の簡単な説明】[Brief description of the drawings]

【図1】本発明の容器の体内埋込型薬液投与装置の概略
図である。
FIG. 1 is a schematic view of a drug solution administration device implantable in a container of the present invention.

【図2】本発明の電力供給手段の一実施例を示す概略図
である。
FIG. 2 is a schematic view showing one embodiment of a power supply means of the present invention.

【図3】本発明の電力供給手段の一実施例を示す概略図
である。
FIG. 3 is a schematic diagram showing one embodiment of a power supply means of the present invention.

【符号の説明】[Explanation of symbols]

1 容器 2 第一領域 3 第二領域 4 放出孔 5 電解質溶液注入孔 6、6’ 電極 7、7’ 端子 8 電源装置 9 弾性膜 10 誘導管 11 薬液投与装置 12 スイッチ 13 受信装置 14 送信装置 15 体内用コイル 16 体外用コイル 17 高周波発生器 18 整流装置 DESCRIPTION OF SYMBOLS 1 Container 2 1st area 3 2nd area 4 Release hole 5 Electrolyte solution injection hole 6, 6 'Electrode 7, 7' Terminal 8 Power supply device 9 Elastic film 10 Guide tube 11 Chemical liquid administration device 12 Switch 13 Receiving device 14 Transmission device 15 Internal coil 16 External coil 17 High frequency generator 18 Rectifier

Claims (2)

【特許請求の範囲】[Claims] 【請求項1】 内部に薬液が注入される第一領域と、前
記第一領域と弾性膜を隔てて隣接する第二領域とを備え
た容器から成る体内埋込型薬液投与装置であって、前記
第二領域は一対の電極を備えているとともに前記第二領
域には電解質溶液が注入されており、前記電極間に電圧
を加えると前記電解質溶液が電気分解されて気体を発生
して前記弾性膜を押し上げて、これによって前記薬液が
前記第一領域に設けられた放出孔から放出されることを
特徴とする薬液投与装置。
1. An implantable drug solution administration device comprising a container having a first region into which a drug solution is injected, and a second region adjacent to the first region with an elastic membrane interposed therebetween, The second region includes a pair of electrodes, and an electrolyte solution is injected into the second region. When a voltage is applied between the electrodes, the electrolyte solution is electrolyzed to generate gas and the elasticity is increased. The liquid medicine administration device, wherein the film is pushed up, whereby the liquid medicine is discharged from a discharge hole provided in the first area.
【請求項2】 前記放出孔は、放出された前記薬液を所
定の場所まで誘導するための誘導管が取り付けられてい
ることを特徴とする請求項1に記載の体内埋込型薬液投
与装置。
2. The implantable medical-solution administration device according to claim 1, wherein a guide tube for guiding the released medical fluid to a predetermined location is attached to the release hole.
JP10124237A 1998-04-17 1998-04-17 Embedded-in-body chemical administering device Pending JPH11299903A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10124237A JPH11299903A (en) 1998-04-17 1998-04-17 Embedded-in-body chemical administering device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10124237A JPH11299903A (en) 1998-04-17 1998-04-17 Embedded-in-body chemical administering device

Publications (1)

Publication Number Publication Date
JPH11299903A true JPH11299903A (en) 1999-11-02

Family

ID=14880372

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10124237A Pending JPH11299903A (en) 1998-04-17 1998-04-17 Embedded-in-body chemical administering device

Country Status (1)

Country Link
JP (1) JPH11299903A (en)

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