JPH1017448A - Plaster for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a plaster for an oral cavity, containing a beautifully tooth- whitening ingredient in an adhesive layer to be adhered to the surfaces of teeth and capable of removing colored substances adhered to the teeth only by adhering the plaster to the teeth. SOLUTION: This plaster for an oral cavity contains a beautifully tooth- whitening agent in an adhesive layer to be adhered to teeth. The plaster can remove colored substances adhered to the teeth by drinking or eating foods or smoking or by the production of colored substances with bacteria or prevent the adhesion of the colored substances to the teeth to whiten the teeth. kojic acid, its salts and its derivatives are especially effective as the beautifully tooth- whitening agent, and the kojic acid compounds have high effects for dissolving and softening the substances (tea incrustations, cigarette tars) adhered to the teeth. The plaster for the oral cavity is preferably prepared by forming and adhesive layer containing the beautifully tooth-whitening ingredient on a support layer consisting mainly of a water-insoluble polymer substance and containing a plasticizer, and is preferably used by adhering the adhesive layer to the tooth surfaces.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral adhesive material suitable for whitening teeth.
The present invention relates to an oral patch for whitening teeth by removing or preventing the coloring of teeth adhered by smoking or colored substances produced by bacteria by dissolving or bleaching with a whitening agent.

[0002]

2. Description of the Related Art
To remove coloring substances attached to teeth, use dentifrice and toothbrush,
It was physically performed by polishing with a polishing component contained in the dentifrice. However, there are cases where it is difficult to completely remove the toothbrush between the teeth, a part where the toothbrush is difficult to reach, such as a dent at the meshing part, and the user's technique. Also, such coloring substances come to the dental clinic,
Although it can be removed by mouth cleaning by specialists such as dentists and dental hygienists, it is necessary to visit the hospital every few months, which is complicated.

An object of the present invention is to improve the above-mentioned circumstances, and to provide an oral patch which can remove a coloring substance adhering to a tooth simply by applying the substance to the tooth.

[0004]

Means for Solving the Problems and Embodiments of the Invention The present inventors have made intensive studies to achieve the above object, and as a result, the present invention has found that the whitening component of the teeth is contained in the adhesive layer attached to and adhered to the teeth. Thereby dissolving the whitening component in a colored substance,
It is possible to whiten teeth by removing coloring matters attached to teeth by the action of bleaching or the like and to prevent coloring substances from adhering to teeth. In this case, kojic acids (koji) are particularly used as tooth whitening components. Acids, kojates, kojic acid derivatives) are effective, and kojic acids are highly effective in dissolving and softening tooth deposits (tea astringent, tobacco tar, etc.), and whitening teeth by including kojic acids in the adhesive layer The present inventors have found that the present invention is excellent in the effect of the present invention, and have accomplished the present invention.

Hereinafter, the present invention will be described in more detail. The oral patch of the present invention comprises a tooth whitening component in an adhesive layer applied to a tooth surface.

In this case, as shown in FIG. 1, the oral adhesive material of the present invention has a form in which an adhesive layer 2 is formed on a support layer 1 and the adhesive layer 2 is attached to and adhered to a tooth surface when used. However, it is needless to say that the present invention is not limited to this.

In this case, the support can be formed by using a water-insoluble polymer substance as a main component and a plasticizer added thereto. Here, as the water-insoluble polymer substance, ethyl cellulose, cellulose acetate, methacrylic acid / methacrylated trimethylammonium copolymer, polyvinyl acetal / dimethylaminoacetate, dimethylaminoethyl methacrylate / methacrylic acid copolymer, cellulose acetate / Dibutyl hydroxypropyl ether, carboxymethylethylcellulose, cellulose acetate phthalate, hydroxypropylmethylcellulose phthalate and the like can be used,
In addition, as the plasticizer, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, glycerin, triacetylene, castor oil, and the like can be used.

In the case of forming the support layer, for example, the water-insoluble polymer substance and the plasticizer are dissolved in an organic solvent, and this is spread on a plastic or metal vat to remove the organic solvent. A method such as drying can be adopted.

The thickness of the support layer is 50 to 500 μm.
m, particularly preferably 200 to 300 μm, from the viewpoint of usability and the like.

On the other hand, the adhesive layer is preferably composed mainly of a water-soluble polymer substance, and a plasticizer and a whitening component are preferably added thereto. Here, as the water-soluble polymer substance, polyvinyl alcohol, polyvinylpyrrolidone, carrageenan, locust bean gum, guar gum, hydroxyethylcellulose, xanthan gum, tragacanth gum, starch, succinoglucan and the like are used. Is mentioned. As the whitening component, ascorbic acid, isoascorbic acid, urea peroxide and the like can be mentioned. In particular, kojic acid, alkali metal salts such as sodium and potassium of kojic acid, and alkaline earth metal salts such as calcium and magnesium, etc. Kojic acid derivatives such as acid salts, carboxylic acid esters of kojic acid, and phosphoric acid esters are preferably used. In this case, the whitening component is preferably 0.05 to 4% (% by weight, the same applies hereinafter), preferably 0.1 to 4%, particularly preferably 0.5 to 2% in the dry adhesive layer.

The method of forming the adhesive layer is also appropriately selected. A method of dissolving or dispersing the water-soluble polymer substance, plasticizer, and whitening component in water, casting the solution on the support layer, and drying. In this case, it is preferable to freeze-dry under vacuum because it is preferable that the adhesive layer is formed in a porous shape and a whitening component such as kojic acid effectively acts on the tooth surface when applied to the tooth.

The thickness of the sticking layer is 200 to 1000 μm.
m, particularly preferably 400 to 800 μm, from the viewpoint of usability and the like. Further, the adhesive layer preferably has a pH of 4.5 to 9, particularly preferably 6 to 8, when it is moistened with saliva or the like in the oral cavity. If the pH is too low, the usability is poor, and if the pH is too high, the effect may be reduced.

[0013] The oral patch of the present invention can be used, for example, by wetting the patch layer with water and sticking and adhering to the teeth, thereby removing the coloring matter adhering to the teeth by the action of the whitening component. It is to whiten teeth.

[0014]

The oral patch of the present invention can remove tea astringency caused by drinking coffee, black tea, green tea, etc., and stains caused by smoking by sticking it to teeth.

[0015]

EXAMPLES The present invention will be described below in detail with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following example, the support layer solution was spread on a plastic vat and dried under vacuum to a thickness of 250 μm.
After the support layer was formed, the adhesive layer solution was spread thereon, and then preliminarily frozen and then freeze-dried to form an adhesive layer having a thickness of 700 μm, thereby producing each oral patch.
In the following examples,% indicates% by weight.

Example 1 1) Adhesive layer Polyvinyl alcohol 10.0 (%) Propylene glycol 3.1 Kojic acid 0.5 Methyl parahydroxybenzoate Trace water 86.6 2) Support layer Ethyl cellulose 10.0 Castor oil 6.0 Food color 4.0 Ethanol 80.0

Example 2 1) Adhesive layer Hydroxyethylcellulose 10.0 (%) Polyethylene glycol 3.1 Kojic acid 1.0 Methyl parahydroxybenzoate Trace water 86.6 2) Support layer Polyvinyl acetal / dimethylaminoacetate 10.0 Castor oil 6.0 Food color 4.0 Ethanol 80.0

Example 3 1) Adhesive layer Hydroxypropylcellulose 10.0 (%) Glycerin 3.1 Kojic acid 0.1 Methyl parahydroxybenzoate Trace water 86.6 2) Support layer Ethyl cellulose 10.0 Castor oil 6.0 Food color 4.0 Ethanol 80.0

Comparative Example 1 1) Adhesive layer Polyvinyl alcohol 10.0 (%) Propylene glycol 3.1 Methyl parahydroxybenzoate Trace water 86.9 2) Support layer Ethyl cellulose 10.0 Castor oil 6.0 Food color 4.0 ethanol 80.0

Next, the tannin stain tip was evaluated using the above-mentioned oral patch by the following method. Tannin stain chip preparation Sandblasted white acrylic chip (color difference E
1) 0.5% aqueous albumin solution → 3% Japanese tea + 1%
It was repeatedly immersed for 1 hour in the order of coffee + 1% aqueous solution of black tea → 0.57% aqueous solution of iron ammonium citrate, and this operation was continued for 2 weeks. The sample was taken out of the stain solution, and the surface of the acrylic chip was lightly brushed in running water to remove stain with weak adhesion, and then air-dried to obtain a sample chip. Evaluation method of tannin stain removal power The color difference (E2) of the sample chip to which tannin stain was adhered was measured, and the adhesive layer of the adhesive material wetted with distilled water was adhered to the chip surface, and subjected to a 100% humidity atmosphere. The color difference (E3) of the sample chip after standing for 1 hour was measured.

The removal rate was calculated by the following equation, and the removal power was evaluated according to the following criteria. Table 1 shows the results. Removal rate (%) = [(E3-E2) / (E1-E2)] ×
100 (However, E1 is the color difference of the chip before attaching tannin stain)

[0022]

[Table 1]

[Brief description of the drawings]

FIG. 1 is a sectional view showing an embodiment of the present invention.

[Explanation of symbols]

 1 support layer 2 sticking layer

Claims (2)

[Claims] 1. An oral patch characterized in that a whitening component of teeth is blended in a patch layer to be stuck to a tooth surface. 2. The oral patch according to claim 1, wherein the whitening component is kojic acid, kojate or a kojic acid derivative.