JPH0989902A - Automatic hemanalysis device - Google Patents
Automatic hemanalysis deviceInfo
- Publication number
- JPH0989902A JPH0989902A JP24292695A JP24292695A JPH0989902A JP H0989902 A JPH0989902 A JP H0989902A JP 24292695 A JP24292695 A JP 24292695A JP 24292695 A JP24292695 A JP 24292695A JP H0989902 A JPH0989902 A JP H0989902A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- plasma
- sample
- sample container
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は血液中の糖を自動的
に分析する装置、特に糖尿病の検査に有用な血液自動分
析装置に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for automatically analyzing sugar in blood, and more particularly to an automatic blood analyzer useful for testing diabetes.
【０００２】[0002]
【従来の技術】血液中の糖の分析には、大別すると、全
血中の血球を分析対象とするグリコヘモグロビン等の分
析と、全血中の血漿を分析対象とするグルコース、グリ
コアルブミン糖の分析とがあり、これに応じて分析装置
も前者に属するものと、後者に属するものとに別れてい
る。そこで、従来、全血中の血漿と血球の両方の分析を
行う場合には、検体を遠心分離機にかけて血漿と血球と
に分離し、この血漿と血球とを別個の容器に分配した
後、それぞれに検体識別コードを付して該等する分析装
置に別個にセットしていた。2. Description of the Related Art Blood sugar in blood can be roughly classified into analysis of glycated hemoglobin and the like for analysis of blood cells in whole blood and glucose and glycoalbumin sugar for analysis of plasma in whole blood. According to this, the analyzers are also divided into those belonging to the former and those belonging to the latter. Therefore, conventionally, when performing analysis of both plasma and blood cells in whole blood, the sample is centrifuged to separate it into plasma and blood cells, and after distributing this plasma and blood cells in separate containers, respectively. The sample identification code was attached to the sample and the sample was separately set in the analyzer.
【０００３】[0003]
【発明が解決しようとする課題】このような装置では、
検体の遠心分離、容器の分配及び識別コードの付与とい
う作業が必要であるため、オペレータの負担が大きいう
え、処理効率が悪い。また、血漿と血球とに分離した検
体を２つ以上に分配するため、識別コードが２通り以上
になり、混乱によるミスが発生しやすい。SUMMARY OF THE INVENTION In such a device,
Since the work of centrifuging the sample, distributing the container, and assigning the identification code is required, the burden on the operator is large and the processing efficiency is poor. Further, since the sample separated into plasma and blood cells is distributed into two or more, there are two or more identification codes, and mistakes due to confusion are likely to occur.
【０００４】そこで、血漿と血球とに遠心分離された検
体容器内の血漿と血球の液面を検出して別々に吸引する
装置が提案されている。例えば、特開平１−２４０８５
９号公報では、電極付きの２本のノズルを設けて、電極
が血漿面を検出すると一方のノズルにより血漿を吸引
し、電極が血球面を検出すると他方のノズルにより血球
を吸引するようにした装置が提案されているが、全体量
の少ない検体又は血漿の量が少ない検体では血漿を吸引
するノズルで血球層を貫通し、血球の混じった血漿を測
定してしまい、測定誤差が生じたり、測定結果が出力さ
れない等の問題があった。また、特公平６−６４０５２
号公報では、検体容器に向けて光を照射し、検体容器を
透過した光を検出することによって検体容器内の血球面
を検出し、該血球面より上方で血漿を吸引して分取する
装置が提案されているが、識別ラベルが貼られた検体容
器では血球面の検出が不能となり、吸引ノズルの先端が
血球層に侵入して血球を吸引してしまう虞れがあった。Therefore, there has been proposed a device for detecting the liquid levels of plasma and blood cells in a sample container that has been centrifuged into plasma and blood cells and aspirating them separately. For example, Japanese Patent Laid-Open No. 1-24085
In Japanese Patent Publication No. 9-2, two nozzles with electrodes are provided, and when the electrode detects a plasma surface, one nozzle sucks blood plasma, and when the electrode detects a blood surface, the other nozzle sucks blood cells. Although a device has been proposed, in a sample with a small total amount or a sample with a small amount of plasma, a nozzle that sucks plasma penetrates the blood cell layer and measures plasma mixed with blood cells, resulting in a measurement error, There was a problem that the measurement result was not output. In addition, Japanese Patent Publication No. 6-64052
In the publication, a device for irradiating a sample container with light and detecting light transmitted through the sample container to detect a blood spherical surface in the sample container, and aspirating and collecting plasma above the blood spherical surface. However, there is a possibility that the blood surface cannot be detected in the sample container to which the identification label is attached, and the tip of the suction nozzle may enter the blood cell layer to suck the blood cell.
【０００５】本発明はかかる問題点に鑑みてなされたも
ので、検体容器に識別ラベルが貼られていても内部の検
体の血漿面及び血球面を検出することができ、血漿に対
する分析と血球又は全血に対する分析とを自動的に行う
ことができる血液自動分析装置を提供することを課題と
する。The present invention has been made in view of the above problems, and it is possible to detect the plasma surface and blood surface of a sample inside even if an identification label is attached to the sample container. It is an object of the present invention to provide an automatic blood analyzer that can perform analysis on whole blood automatically.
【０００６】[0006]
【課題を解決するための手段】前記課題を解決するた
め、本発明は、検体容器内の血液検体の血漿と血球、又
は全血を吸引して分析を行う血液自動分析装置におい
て、前記検体容器を把持して昇降し、回転させる検体容
器昇降回転手段と、前記検体容器の近傍に配設された光
源と該光源から発射されて検体容器の表面で反射した光
の光量を検出する光センサからなり、検体容器に貼られ
た識別ラベルの表面で反射した光の光量によって識別コ
ードを読み取るとともに、識別ラベルの周方向の両端間
に形成される隙間を通して得られる検体からの反射光量
の差によって検体容器内の血液検体の血漿面及び血球面
を検出する液面検出手段とを備えたものである。In order to solve the above problems, the present invention provides an automatic blood analyzer for aspirating and analyzing plasma and blood cells or whole blood of a blood sample in a sample container. From a sample container elevating and rotating means for gripping, elevating, and rotating, a light source arranged near the sample container, and an optical sensor for detecting the amount of light emitted from the light source and reflected on the surface of the sample container. And read the identification code by the amount of light reflected on the surface of the identification label attached to the sample container, and the sample by the difference in the amount of light reflected from the sample obtained through the gap formed between the ends of the identification label in the circumferential direction. And a liquid level detecting means for detecting the plasma surface and the blood spherical surface of the blood sample in the container.
【０００７】前記の構成の発明において、血液検体が収
容された検体容器を装置にセットすると、検体容器は昇
降回転手段によって回転させられる。液面検出手段は、
検体で反射する光源からの光を光センサで検出すること
により、識別ラベルに付された識別コードを読み取ると
ともに、検体容器内の検体の血漿面と血球液面を検出す
る。液面検出手段が血漿面及び血球面の両方を検出した
場合には、吸引ノズルによって血漿と血球が吸引され
て、分析手段によって分析される。液面検出手段が血漿
面を検出したが血球面を検出しない場合には、吸引ノズ
ルによって血漿のみが吸引され、分析手段により分析さ
れる。液面検出手段が血漿面は検出しないが血球面を検
出した場合には、吸引手段によって全血が吸引され、分
析手によって分析される。In the invention of the above structure, when the sample container containing the blood sample is set in the apparatus, the sample container is rotated by the elevating and rotating means. The liquid level detection means is
By detecting the light from the light source reflected by the sample with the optical sensor, the identification code attached to the identification label is read and the plasma surface and the blood cell surface of the sample in the sample container are detected. When the liquid level detecting means detects both the plasma surface and the blood spherical surface, the suction nozzle sucks the plasma and the blood cells and analyzes them by the analyzing means. When the liquid level detecting means detects the plasma surface but does not detect the blood surface, only the plasma is sucked by the suction nozzle and analyzed by the analyzing means. When the liquid level detecting means does not detect the plasma surface but detects the blood spherical surface, the whole blood is sucked by the suction means and analyzed by the analyzer.
【０００８】[0008]
【発明の実施の形態】以下、本発明の実施の形態を添付
図面に従って説明する。図１は、本発明にかかる血液自
動分析装置の概略配置図を示す。装置の正面側には右よ
りラック導入プール１、ラック排出プール２、エラー検
体プール３が配設されている。ラック導入プール１は、
複数（例えば１０検体）の検体容器４を保持可能な検体
ラック５を複数（例えば１０ラック）整列させて架設す
ることができる。検体容器４は、図２に示すように、予
め遠心分離機等によって血漿と血球とに分離された血液
検体が収容されている。この検体容器４の外表面には、
検体識別コードとしてバーコード６が付された識別ラベ
ル７が貼られている。また、ラック導入プール１は、図
１に示すように、先頭の検体ラック５を順次矢印Ａで示
す縦方向に搬送して装置中央に移動させることができ
る。中央に移動した検体ラック５は、横送り装置８によ
って１ホールピッチごと、あるいは連続して矢印Ｂで示
す横方向に移動させることができる。BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below with reference to the accompanying drawings. FIG. 1 shows a schematic layout of an automatic blood analyzer according to the present invention. A rack introduction pool 1, a rack discharge pool 2, and an error sample pool 3 are arranged from the right on the front side of the apparatus. Rack introduction pool 1
A plurality of (for example, 10 racks) sample racks 5 capable of holding a plurality of (for example, 10 samples) sample containers 4 can be aligned and installed. As shown in FIG. 2, the sample container 4 contains a blood sample that has been separated into plasma and blood cells in advance by a centrifuge or the like. On the outer surface of the sample container 4,
An identification label 7 with a barcode 6 as a sample identification code is attached. Further, in the rack introduction pool 1, as shown in FIG. 1, the leading sample rack 5 can be sequentially transported in the vertical direction indicated by the arrow A and moved to the center of the apparatus. The sample rack 5 that has been moved to the center can be moved in the horizontal direction indicated by arrow B by the horizontal feed device 8 at every hole pitch or continuously.
【０００９】ラック排出プール２は、前記横送り装置８
によってラック導入プール１から搬送されてきた測定済
みの検体ラック５を矢印Ｃで示す縦方向に搬送して一時
的に保管できるようになっている。また、エラー検体プ
ール３も、同様にして、前記横送り装置８によってラッ
ク導入プール１から搬送されてきたエラー検体を含む検
体ラック５を矢印Ｄで示す縦方向に搬送して一時的に保
管できるようになっている。エラー検体としては、全血
検体、血漿極小検体、血漿検体、液なし検体、バーコー
ド読取りミス検体等がある。The rack discharge pool 2 is provided with the transverse feed device 8
Thus, the measured sample rack 5 transferred from the rack introduction pool 1 can be transferred in the vertical direction indicated by the arrow C and temporarily stored. Similarly, in the error sample pool 3, the sample rack 5 containing the error sample transported from the rack introduction pool 1 by the lateral feeding device 8 can be transported in the vertical direction indicated by the arrow D to be temporarily stored. It is like this. Examples of error samples include whole blood samples, minimal plasma samples, plasma samples, liquid-free samples, and barcode reading error samples.
【００１０】前記ラック導入プール１とラック排出プー
ル２の間であって、かつ、前記横送り装置８の上方に
は、検体容器昇降回転機構９、検体容器長センサ１０、
液面及びバーコード検出装置１１、及び吸引ノズル１２
が配設されている。検体容器昇降回転機構９は、図２に
示すように、前記識別ラベル７が貼られていない管上端
から５ｍｍまでの部分を爪で把持し、その状態で検体容
器４をバーコード６及び液面Ｌ1，Ｌ2の読取り位置に上
昇させて約３０ｒｐｍで１回転させた後、元のラック位
置まで降下させることができるようになっている。検体
容器長センサ１０は、検体容器４には７５ｍｍと１００
ｍｍの長さが異なるものがあるので、個々の検体容器４
の長さを識別してその長さに応じて検体容器昇降回転機
構９による検体容器４の昇降量を変更することにより、
検体容器４を確実に把持したり、バーコード６を正確に
読み取ったりすることができるようになっている。Between the rack introduction pool 1 and the rack discharge pool 2 and above the transverse feed device 8, a sample container elevating / rotating mechanism 9, a sample container length sensor 10,
Liquid level and bar code detection device 11, and suction nozzle 12
Are arranged. As shown in FIG. 2, the sample container elevating / rotating mechanism 9 grips the part from the upper end of the tube where the identification label 7 is not attached up to 5 mm with a nail, and in that state holds the sample container 4 with the barcode 6 and the liquid surface. After being raised to the reading position of L 1 and L 2 and rotated once at about 30 rpm, it can be lowered to the original rack position. The sample container length sensor 10 has 75 mm and 100 mm for the sample container 4.
Since the lengths of mm are different, each sample container 4
By changing the length of the sample container 4 and changing the lifting amount of the sample container 4 by the sample container lifting / lowering rotation mechanism 9 according to the length,
The sample container 4 can be reliably gripped and the barcode 6 can be read accurately.
【００１１】液面及びバーコード検出装置１１は、光源
１３と光センサ１４からなっている。光源１３としては
検体容器４の軸方向に細長いＬＥＤが好ましい。また、
光センサ１４としては複数の受光素子を検体容器４の軸
方向に沿って１列に配設したＣＣＤリニアイメージセン
サが好ましい。この光センサ１４は、光源１３から検体
容器４の表面で反射した光を受光できるように配設され
ている。吸引ノズル１２は、２本の平行に並設された血
漿吸引用のａノズル１２ａと血球吸引用のｂノズル１２
ｂからなっている。これらのノズル１２ａ，１２ｂは、
検体容器４から血漿と血球とをそれぞれ吸引して分取
し、後述する血漿分析測定器１５、血球分析測定器１６
の図示しない反応層にそれぞれ移動して吐出するように
なっている。The liquid surface and bar code detecting device 11 comprises a light source 13 and an optical sensor 14. As the light source 13, an LED elongated in the axial direction of the sample container 4 is preferable. Also,
As the optical sensor 14, a CCD linear image sensor in which a plurality of light receiving elements are arranged in a line along the axial direction of the sample container 4 is preferable. The optical sensor 14 is arranged so as to be able to receive the light reflected by the surface of the sample container 4 from the light source 13. The suction nozzle 12 includes two a nozzles 12 a for plasma suction and a b nozzle 12 for blood cell suction that are arranged in parallel.
It consists of b. These nozzles 12a and 12b are
Plasma and blood cells are respectively sucked and collected from the sample container 4, and a plasma analysis measuring instrument 15 and a blood cell analyzing measuring instrument 16 to be described later are provided.
It moves to each of the reaction layers (not shown) and discharges.
【００１２】一方、装置の背面側には、左側より血漿分
析測定器１５、血球分析測定器１６、プリンタ１７、及
び制御装置１８が配設されている。血漿分析測定器１５
は、吸引分取された血漿中のグルコース、グリコアルブ
ミン等の糖分を測定し分析する。また、血球分析測定器
１６は、吸引分取された血球又は全血からグリコヘモグ
ロビン等を測定し分析するようになっている。プリンタ
１７は、前記血漿分析測定器１５及び血球分析測定器１
６で得られた分析データを出力する装置である。前述の
各装置はマイクロコンピュータ及びメモリを備えた制御
装置１８によって制御される。On the other hand, on the back side of the apparatus, a plasma analysis measuring instrument 15, a blood cell analysis measuring instrument 16, a printer 17, and a controller 18 are arranged from the left side. Plasma analysis measuring instrument 15
Is to measure and analyze sugars such as glucose and glycoalbumin in the aspirated plasma. Further, the blood cell analysis and measurement device 16 is adapted to measure and analyze glycated hemoglobin and the like from blood cells or whole blood that have been aspirated and collected. The printer 17 includes the plasma analysis measurement device 15 and the blood cell analysis measurement device 1.
This is a device for outputting the analysis data obtained in 6. Each of the above-mentioned devices is controlled by a controller 18 having a microcomputer and a memory.
【００１３】次に、上記構成からなる装置の動作を図３
及び図４に示すフローチャートに従って説明する。Next, the operation of the apparatus configured as described above will be described with reference to FIG.
And it demonstrates according to the flowchart shown in FIG.
【００１４】まず、ステップ１０１でラック導入プール
１に整列待機している検体ラック５のうち先頭の検体ラ
ック５を矢印Ａ方向に縦送りし、ステップ１０２で横送
り装置８によって検体ラック５を矢印Ｂ方向に１ポート
横送りした後、ステップ１０３で検体容器長センサ１０
によって検体容器４の長さを読み取る。そして、この検
体容器４の長さに応じて検体容器昇降回転機構９を降下
させて、ステップ１０４で検体容器４を把持し、ステッ
プ１０５で検体容器４を常に容器上端が一定の高さとな
るバーコード及び液面の読み取り位置まで上昇させ、ス
テップ１０６で検体容器４のバーコード６及び液面
Ｌ1，Ｌ2を読み取る。この読み取り動作については後に
詳細に説明する。バーコード６及び液面Ｌ1，Ｌ2の読み
取りが終了すると、ステップ１０７で検体容器４を降下
させて元の位置に戻し、ステップ１０８で検体容器４を
はなした後、ステップ１０９で横送り装置８によって検
体ラック５を矢印Ｂ方向に１ポート横送りする。First, in step 101, the leading sample rack 5 among the sample racks 5 waiting in line in the rack introduction pool 1 is vertically fed in the direction of arrow A, and in step 102, the horizontal rack feeder 8 moves the sample rack 5 to the arrow. After feeding 1 port laterally in the B direction, in step 103, the sample container length sensor 10
The length of the sample container 4 is read by. Then, the sample container elevating and rotating mechanism 9 is lowered according to the length of the sample container 4, the sample container 4 is gripped in step 104, and the sample container 4 is constantly held in step 105 at a bar whose upper end is always at a constant height. The bar code 6 and the liquid levels L 1 and L 2 of the sample container 4 are read in step 106 by raising the code and the liquid level reading position. This reading operation will be described later in detail. When the reading of the barcode 6 and the liquid surfaces L 1 and L 2 is completed, the sample container 4 is lowered to the original position in step 107, the sample container 4 is released in step 108, and then the sample container 4 is laterally fed in step 109. The apparatus 8 laterally feeds the sample rack 5 in the direction of arrow B by one port.
【００１５】続いて、ステップ１１０において、読み取
った液面情報に基づいて血漿面Ｌ1があるか否かを判断
し、あればステップ１１１で血球面Ｌ2があるか否かを
判断する。血漿面Ｌ1と血球面Ｌ2の両方があれば、ステ
ップ１１２で、血漿面Ｌ1と血球液面Ｌ2の差に基づいて
血漿を吸引可能な範囲かを判断する。この場合、血漿面
Ｌ1と血球液面Ｌ2の差が５ｍｍ程度以上であれば血漿を
吸引可能とする。血漿を吸引可能であれば、ステップ１
１３で血漿用のａノズル１２ａを血球液面Ｌ2よりやや
高い位置まで降下させ、ステップ１１４で当該ａノズル
１２ａにより血漿を吸引する。続いて、ステップ１１５
で血球用のｂノズル１２ｂを管底まで降下させ、ステッ
プ１１６で当該ｂノズル１２ｂにより血球を吸引する。
次に、ステップ１１７でａノズル１２ａとｂノズル１２
ｂを共に上昇させ、ステップ１１８でそれぞれの分析測
定器１５，１６の反応層へ移動させ、ステップ１１９で
ａノズル１２ａから血漿を吐出し、ステップ１２０でｂ
ノズル１２ｂから血球を吐出する。Next, at step 110, it is judged whether or not there is a plasma surface L 1 based on the read liquid surface information, and if so, it is judged at step 111 whether or not there is a blood surface L 2 . If both the plasma surface L 1 and the blood spherical surface L 2 are present, it is determined in step 112 based on the difference between the plasma surface L 1 and the blood cell liquid surface L 2 whether or not the plasma can be aspirated. In this case, if the difference between the plasma surface L 1 and the blood cell surface L 2 is about 5 mm or more, the plasma can be sucked. If plasma can be aspirated, step 1
At 13, the a nozzle 12a for plasma is lowered to a position slightly higher than the blood cell surface L 2 , and at step 114, the plasma is sucked by the a nozzle 12a. Then, step 115.
In step 116, the b-nozzle 12b for blood cells is lowered to the bottom of the tube, and in step 116, blood cells are sucked by the b-nozzle 12b.
Next, in step 117, the a nozzle 12a and the b nozzle 12
b is raised together and is moved to the reaction layers of the analytical measuring instruments 15 and 16 in step 118, plasma is discharged from the nozzle 12a in step 119, and b in step 120.
Blood cells are ejected from the nozzle 12b.
【００１６】前記ステップ１１２で血漿の吸引可能範囲
でなければ、ステップ１２１で血漿がない旨の異常を報
知し、ステップ１２２で血球用のｂノズル１２ｂを管底
まで降下させ、ステップ１２３で当該ｂノズル１２ｂに
より血球を吸引する。次に、ステップ１２４でｂノズル
１２ｂを上昇させ、ステップ１２５で分析測定器１６の
反応層へ移動させて、ステップ１２６でｂノズル１２ｂ
から血球を吐出する。If the plasma is not in the suckable range in step 112, an abnormality indicating that there is no plasma is reported in step 121, the b nozzle 12b for blood cells is lowered to the tube bottom in step 122, and the b in step 123 is performed. Blood cells are sucked by the nozzle 12b. Next, in step 124, the b-nozzle 12b is moved up, in step 125, it is moved to the reaction layer of the analytical measuring instrument 16, and in step 126, the b-nozzle 12b.
Eject blood cells from.
【００１７】前記ステップ１１１で血球面がないと判断
すれば、ステップ１２７で血球がない旨の異常を報知
し、ステップ１２８で血漿用のａノズル１２ａを血球液
面Ｌ2よりやや高い位置まで降下させ、ステップ１２９
で当該ａノズル１２ａにより血漿を吸引する。次に、ス
テップ１３０でａノズル１２ａを上昇させ、ステップ１
３１で分析測定器１５の反応層へ移動させ、ステップ１
３２でａノズル１２ａから血漿を吐出する。If it is determined in step 111 that there are no blood cells, an abnormality indicating that there are no blood cells is issued in step 127, and in step 128 the a nozzle 12a for plasma is lowered to a position slightly higher than the blood cell liquid level L 2. And step 129
Then, the plasma is sucked by the a nozzle 12a. Next, in step 130, the a nozzle 12a is raised, and in step 1
At step 31, the sample is moved to the reaction layer of the analytical measuring instrument 15, and step 1
At 32, the plasma is discharged from the a nozzle 12a.
【００１８】前記ステップ１００で血漿面がないと判断
すれば、ステップ１３３で血球面２があるか否かを判断
する。ここで、血球面Ｌ２があれば、ステップ１３４で
全血である旨の異常を報知し、ステップ１３５で血球用
のｂノズル１２ｂを管底まで降下させ、ステップ１３６
で当該ｂノズル１２ｂにより血球を吸引する。次に、ス
テップ１３７でｂノズル１２ｂを上昇させ、ステップ１
３８で分析測定器１６の反応層へ移動させ、ステップ１
３９でｂノズル１２ｂから全血を吐出する。なお、ステ
ップ１３３で血球面Ｌ2がなければ、ステップ１４０で
検体がない旨の異常を報知する。If it is judged in step 100 that there is no plasma surface, it is judged in step 133 whether there is a blood surface 2 . Here, if there is a blood spherical surface L 2, an abnormality indicating that it is whole blood is notified in step 134, the b nozzle 12b for blood cells is lowered to the tube bottom in step 135, and step 136 is performed.
Then, the blood cells are sucked by the b nozzle 12b. Next, in step 137, the b-nozzle 12b is raised, and step 1
At 38, move to the reaction bed of the analytical measuring instrument 16, and perform step 1
At 39, whole blood is discharged from the b nozzle 12b. If there is no blood surface L 2 in step 133, an abnormality indicating that there is no sample is notified in step 140.
【００１９】このように、光センサで読み取った液面情
報により、血漿面Ｌ1と血球面Ｌ2があってかつ血漿が吸
引可能であれば血漿と血球を共に吸引して分析を行い、
血漿が吸引可能でなければ血球のみを吸引して分析を行
う。また、血漿面Ｌ1があって血球面Ｌ2がなければ、血
球なしの異常報知し、血漿のみを吸引して分析し、血漿
面Ｌ1がなくて血球面Ｌ2があれば、これはすなわち全血
状態であるので、全血の異常を報知し、全血を吸引して
分析を行う。As described above, if there is the plasma surface L 1 and the blood spherical surface L 2 based on the liquid surface information read by the optical sensor and the plasma can be sucked, both the blood plasma and the blood cells are sucked for analysis.
If plasma cannot be aspirated, only blood cells are aspirated for analysis. If there is a plasma surface L 1 and there is no blood surface L 2 , an abnormality is notified without blood cells, only plasma is sucked and analyzed, and if there is no plasma surface L 1 and there is a blood surface L 2 , this is That is, since it is a whole blood state, an abnormality of the whole blood is notified, and the whole blood is sucked and analyzed.
【００２０】図４は、前記ステップ１０６における検体
容器４のバーコード６及び液面Ｌ1，Ｌ2の読み取りのフ
ローを示す。ステップ２０１で光源１３のＬＥＤを点灯
し、ステップ２０２で検体容器昇降回転機構９によって
約３０ｒｐｍ程度で検体容器４の回転を開始し、ステッ
プ２０３で光センサ１４による読み取りを開始する。光
源１３のＬＥＤから放射された光は回転する検体容器４
の表面で反射して光センサ１４に入力される。回転容器
４の表面に貼られた識別ラベル７のバーコード６の黒部
分と白部分でそれぞれ反射した光は光量に差が生じる。
また、識別ラベル７の両端間の隙間から見える検体容器
４内の空間層と検体層、及び血漿層と血球層の上下でそ
れぞれ反射した光にも光量に差が生じる。したがって、
光センサ１４のライン状に配設された各受光素子のうち
受光量に大幅な差がある隣接する受光素子間に、バーコ
ードの白黒の境界面、あるいは空間層と検体層の間の境
界面又は血漿と血球の境界面が存在することになる。FIG. 4 shows a flow of reading the bar code 6 and the liquid surfaces L 1 and L 2 of the sample container 4 in step 106. In step 201, the LED of the light source 13 is turned on, in step 202 the sample container lifting / lowering rotation mechanism 9 starts rotating the sample container 4 at about 30 rpm, and in step 203, the optical sensor 14 starts reading. The light emitted from the LED of the light source 13 rotates the specimen container 4
The light is reflected by the surface of the light source and input to the optical sensor 14. The light reflected by the black portion and the white portion of the barcode 6 of the identification label 7 attached to the surface of the rotary container 4 has a different amount of light.
In addition, the amount of light is also different between the light reflected respectively above and below the space layer and the sample layer in the sample container 4, and the plasma layer and the blood cell layer, which are visible from the gap between both ends of the identification label 7. Therefore,
A black-and-white boundary surface of a barcode or a boundary surface between a space layer and a sample layer is provided between adjacent light receiving elements having a large difference in light receiving amount among the light receiving elements arranged in a line of the optical sensor 14. Or, there is an interface between plasma and blood cells.
【００２１】そこで、ステップ２０４で前記センサ情報
により境界面が３つ以上あるか否かを判断し、３つ以上
あればバーコード情報であるから、ステップ２０５で前
回のバーコード情報が記憶されているかどうか判断し、
記憶されていないければステップ２０８でそのバーコー
ド情報を記憶し、ステップ２０９で１回転していないと
判断すればステップ２０４に戻って読み取りを繰り返
す。また、ステップ２０５で前回のバーコード情報が記
憶されていれば、ステップ２０６でそのバーコード情報
が前のバーコード情報と一致しているかどうかをみて、
一致していればステップ２０７でそれが３回以上の一致
かどうか判断し、そうであればステップ２０８でそのバ
ーコード情報を記憶する。前記ステップ２０６でそのバ
ーコード情報が前のバーコード情報と一致しなかった
り、ステップ２０７で３回以上一致しなかった場合に
は、バーコード６に異常があると考えられるので、その
ようなバーコード情報は記憶しない。Therefore, in step 204, it is judged from the sensor information whether there are three or more boundary surfaces, and if there are three or more boundary surfaces, the barcode information is stored. Therefore, in step 205, the previous barcode information is stored. Determine if there is
If not stored, the bar code information is stored in step 208, and if it is determined in step 209 that one rotation has not been performed, the process returns to step 204 and the reading is repeated. If the previous bar code information is stored in step 205, it is checked in step 206 whether the bar code information matches the previous bar code information.
If they match, it is judged in step 207 whether or not they match three times or more, and if they match, the bar code information is stored in step 208. If the barcode information does not match the previous barcode information in step 206 or does not match three times or more in step 207, it is considered that the barcode 6 is abnormal. Does not store code information.
【００２２】一方、検体容器４が１回転する間に、光源
１３からの光が識別ラベル７の両端間の隙間で反射する
と、バーコード６で反射したときと比べて境界面が少な
くなる。検体容器４内の血液検体が全血の場合は、境界
面は全血液面Ｌ1のみの１つとなるが、血液検体４が遠
心分離等によって血漿と血球とに分離されている場合
は、境界面は血漿面Ｌ1と血球液面Ｌ2の２つとなる。On the other hand, when the light from the light source 13 is reflected by the gap between both ends of the identification label 7 during one rotation of the sample container 4, the boundary surface becomes smaller than that when reflected by the barcode 6. When the blood sample in the sample container 4 is whole blood, the boundary surface is only one of the whole blood surface L 1, but when the blood sample 4 is separated into plasma and blood cells by centrifugation or the like, the boundary surface is There are two surfaces, a plasma surface L 1 and a blood cell liquid surface L 2 .
【００２３】したがって、このように光源１３からの光
が識別ラベルの両端間の隙間で反射した場合には境界面
が１つ又は２つとなるので、前記ステップ２０４におけ
るセンサ情報により境界面が３つ以上あるか否かの判断
でＮＯとなり、バーコード情報ではなく液面情報である
と判断する。そして、ステップ２１０で前回の液面情報
が記憶されているかどうか判断し、記憶されていないけ
ればステップ２１３でその液面情報を記憶し、ステップ
２０９で１回転していないと判断すればステップ２０４
に戻って読み取りを繰り返す。また、ステップ２１０で
前回の液面情報が記憶されていれば、ステップ２１１で
その液面情報が前の液面情報と一致しているかどうかを
みて、一致していればステップ２１２でそれが３回以上
の一致かどうか判断し、そうであればステップ２１３で
その液面情報を記憶する。前記ステップ２１１でその液
面情報が前の液面情報と一致しなかったり、ステップ２
１２で３回以上一致しなかった場合には、液面に異常が
あると考えられるので、そのような液面情報は記憶しな
い。Therefore, when the light from the light source 13 is reflected by the gap between the both ends of the identification label in this way, there are one or two boundary surfaces, and therefore, there are three boundary surfaces according to the sensor information in step 204. The determination of whether or not there is the above is NO, and it is determined that the liquid level information is not the bar code information. Then, in step 210, it is determined whether or not the previous liquid surface information is stored. If it is not stored, the liquid surface information is stored in step 213, and if it is determined in step 209 that one rotation has not been performed, step 204
Return to and repeat reading. If the previous liquid surface information is stored in step 210, it is checked in step 211 whether the liquid surface information matches the previous liquid surface information. It is judged whether or not they match more than once, and if so, the liquid level information is stored in step 213. If the liquid level information does not match the previous liquid level information in step 211, step 2
If the numbers 12 do not match three times or more, it is considered that there is an abnormality in the liquid surface, and such liquid surface information is not stored.
【００２４】このように、検体容器４が１回転する間に
光センサ１４により読み取ったバーコード情報又は液面
情報が３回以上一致するまで待って記憶するので、信頼
性の高い正確な読み取りが行われる。検体容器４が１回
転すると、ステップ２１４で光センサ１４により読取り
を終了とし、ステップ２１５で検体容器４の回転を終了
し、ステップ２１６で光源１３のＬＥＤを消灯する。As described above, since the barcode information or the liquid level information read by the optical sensor 14 is stored three times or more during one rotation of the sample container 4 and stored, the reliable and accurate reading can be performed. Done. When the sample container 4 makes one rotation, the reading by the optical sensor 14 is ended in step 214, the rotation of the sample container 4 is ended in step 215, and the LED of the light source 13 is turned off in step 216.
【００２５】[0025]
【発明の効果】以上の説明から明らかなように、本発明
によれば、検体容器を回転させ、検体容器に貼られた識
別コードを読み取るとともに、識別コードの両端の隙間
から血漿面と血球面の液面を読み取るので、識別コード
と液面を読み取る２つの読み取り装置を設ける必要がな
く、装置の構造が簡単かつ安価になる。また、検体容器
に識別ラベルが貼ってあっても、内部の検体の液面を検
出できるので、血漿と血球、又は全血を確実に吸引して
分析することができる。さらに、血漿面と血球液面、あ
るいは全血液面を検出できるので、検体容器内の血液検
体が予め血漿と血液とに分離された検体、あるいは全血
状態の検体であっても分析を行える。As is apparent from the above description, according to the present invention, the sample container is rotated and the identification code affixed to the sample container is read, and the plasma surface and the blood spherical surface are obtained from the gaps at both ends of the identification code. Since the liquid level is read, it is not necessary to provide two reading devices for reading the identification code and the liquid level, and the structure of the device is simple and inexpensive. Further, even if the identification label is attached to the sample container, since the liquid level of the sample inside can be detected, plasma and blood cells or whole blood can be surely sucked and analyzed. Furthermore, since the plasma surface and the blood cell liquid surface or the whole blood surface can be detected, analysis can be performed even if the blood sample in the sample container is a sample in which plasma and blood have been separated in advance, or a sample in the whole blood state.
【図１】 血液自動分析装置の概略平面図である。FIG. 1 is a schematic plan view of an automatic blood analyzer.
【図２】 図１に示す装置の検体容器昇降回転機構、液
面及びバーコード検出装置、及び吸引ノズルの斜視図で
ある。FIG. 2 is a perspective view of a sample container lifting / lowering rotation mechanism, a liquid surface / bar code detection device, and a suction nozzle of the device shown in FIG.
【図３】 図１に示す装置の動作を示すフローチャート
である。FIG. 3 is a flowchart showing an operation of the apparatus shown in FIG.
【図４】 図３に続くフローチャートである。FIG. 4 is a flowchart following FIG.
【図５】 図１に示す装置の検体容器のバーコード及び
液面検出動作を示すフローチャートである。5 is a flowchart showing a barcode and liquid level detection operation of the sample container of the apparatus shown in FIG.
４…検体容器、６…バーコード（識別コード）、７…識
別ラベル、９…検体容器昇降回転機構、１１…液面及び
バーコード検出装置、１２…吸引ノズル、１３…光源、
１４…光センサ、１５…血漿分析測定器、１６…血球分
析測定器、Ｌ1…血漿面、Ｌ2…血球面。4 ... Sample container, 6 ... Bar code (identification code), 7 ... Identification label, 9 ... Sample container lifting / lowering rotation mechanism, 11 ... Liquid level and bar code detection device, 12 ... Suction nozzle, 13 ... Light source,
14 ... Optical sensor, 15 ... Plasma analysis and measurement device, 16 ... Blood cell analysis and measurement device, L 1 ... Plasma surface, L 2 ... Blood surface.
Claims (1)
は全血を吸引して分析を行う血液自動分析装置におい
て、 前記検体容器を把持して昇降し、回転させる検体容器昇
降回転手段と、 前記検体容器の近傍に配設された光源と該光源から発射
されて検体容器の表面で反射した光の光量を検出する光
センサからなり、検体容器に貼られた識別ラベルの表面
で反射した光の光量によって識別コードを読み取るとと
もに、識別ラベルの周方向の両端間に形成される隙間を
通して得られる検体からの反射光量の差によって検体容
器内の血液検体の血漿面及び血球面を検出する液面検出
手段とを備えたことを特徴とする血液自動分析装置。1. An automatic blood analyzer for sucking plasma and blood cells or whole blood of a blood sample in a sample container for analysis, and a sample container elevating and rotating means for gripping, elevating and rotating the sample container. A light source disposed in the vicinity of the sample container and an optical sensor for detecting the amount of light emitted from the light source and reflected on the surface of the sample container, and reflected on the surface of the identification label attached to the sample container. A liquid that reads the identification code by the amount of light and detects the plasma surface and blood spherical surface of the blood sample in the sample container by the difference in the amount of reflected light from the sample obtained through the gap formed between both ends in the circumferential direction of the identification label. An automatic blood analyzer comprising: a surface detecting means.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24292695A JP3574939B2 (en) | 1995-09-21 | 1995-09-21 | Automatic blood analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24292695A JP3574939B2 (en) | 1995-09-21 | 1995-09-21 | Automatic blood analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0989902A true JPH0989902A (en) | 1997-04-04 |
| JP3574939B2 JP3574939B2 (en) | 2004-10-06 |
Family
ID=17096276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24292695A Expired - Fee Related JP3574939B2 (en) | 1995-09-21 | 1995-09-21 | Automatic blood analyzer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3574939B2 (en) |
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| JP2002196008A (en) * | 2000-12-26 | 2002-07-10 | Shimadzu Corp | Autosampler |
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| US9588038B2 (en) | 2012-09-14 | 2017-03-07 | Beckman Coulter, Inc. | Analytical system with capillary transport |
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1995
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| JPH11326337A (en) * | 1998-05-19 | 1999-11-26 | Aloka Co Ltd | Label reading apparatus |
| JP2002196008A (en) * | 2000-12-26 | 2002-07-10 | Shimadzu Corp | Autosampler |
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