JPH0930927A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin preparation for external use, having a moisture-retaining effect, an effect for preventing and improving skin roughness, and an effect for preventing and improving the formation of skin wrinkles, and excellent in a skin aging-preventing effect. SOLUTION: A skin preparation for external use contains the following components (A) and (B). (A) 0.0001-20wt.% (converted into the dried solid content) of the extracts of one or more kinds of plants selected from Hamamelis virginiana L., Poeoma suffruticosa Andr., Zingiber officinale Roscoe and Euphorbia rathyris L. (B) 0.0001-20wt.% of an acidic heterogeneous polysaccharide originated from a plant (e.g. Polianthes tuberosa L.,) belonging to the genus Polianthes L. The skin preparation may further suitably be compounded with conventional additives and subsequently prepared into a medicinal skin ointment preparation for the external use and further into a skin cosmetic such as a water/oil or oil/water type emulsion cosmetic, a cream, an emulsion, a beauty water, a pack, a lip stick, a foundation, a skin cleanser, a hair-dressing agent or a hair tonic. The extraction of the plant is performed by a method comprising extracting the various plants with a solvent (e.g. ethanol). The component (B) is obtained by culturing a callus derived from the plant belonging to the Polianthes L.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which is excellent in skin aging prevention effects such as moisturizing the skin, preventing and improving rough skin, and preventing and improving wrinkle formation.

[0002]

2. Description of the Related Art In recent years, maintaining healthy and beautiful skin has become a serious concern for men and women of all ages. However, the skin is subtly affected by aging, temperature, humidity, ultraviolet rays, cosmetics, diseases, stress, eating habits, etc., and therefore various functions of the skin (prevention of loss of water etc. from the living body and constant body temperature). Various functions, such as the function to control the physical maintenance, the physical and chemical stimuli from the outside world and the function to protect the body from various bacteria, the function to maintain the elasticity of the skin and determine the surface morphology), the aging of the skin, etc. Trouble occurs.

Further, as described above, the skin trouble is caused by a change in the external environment (seasonal change, ultraviolet rays, etc.) and a function of the skin tissue due to internal and external factors acting on the living body such as changes in physiological functions due to aging and diseases. In addition to abnormalities, it is caused by skin thickening and parakeratosis induced by these.

[0004] The main attempts to prevent and improve such skin troubles are to apply a synthetic or natural moisturizing component to prevent the skin from drying and to enhance the moisturizing ability of the skin.
Methods for improving the promotion of blood circulation by applying a blood circulation promoting agent have been made.

That is, free amino acids, organic acids, urea,
The use of humectants such as inorganic ions and polysaccharides such as hyaluronic acid, animal and plant extracts, vitamins and derivatives thereof, peptides, proteins, and medicated skin external preparations and cosmetics containing hydroxy acids, etc., causes the above skin troubles. Attempts have been made to prevent and improve

However, even if such a component is applied to the skin, its effect is low and it is temporary, and it has not been essential to prevent or ameliorate the skin trouble.

On the other hand, wrinkles, which are one of the skin troubles, occur due to aging due to aging, drying, ultraviolet rays and the like.
That is, dryness, changes in the surface morphology of the epidermis due to physical and chemical stimuli from the outside such as ultraviolet rays and aging, diseases, degeneration of tissues in the dermis due to stress, etc., in particular, collagen fibers are largely lost and degeneration of the dermis, The skin ages due to a decrease in subcutaneous adipose tissue, etc., which mainly causes wrinkle relaxation and loss of elasticity.

Conventionally, various compositions and methods have been proposed in order to suppress or treat such wrinkles due to aging (Japanese Patent Laid-Open No. 185005/1987).
JP-A-62-502546, JP-A-2-7215
No. 7, JP-A-2-288822, etc.). However, none of these showed a satisfactory wrinkle reducing effect.

[0009]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a skin external preparation which is excellent in skin aging prevention effects such as moisturizing effects, prevention and improvement effects of rough skin, and prevention and improvement effects of wrinkle formation. It is in.

[0010]

Under such circumstances, the present inventors have conducted diligent research, and as a result, when a specific plant extract and an acidic heteropolysaccharide were used in combination, the skin having an excellent anti-aging effect on the skin was obtained. The present invention has been completed by finding that an external preparation can be obtained.

That is, the present invention provides the following components (A) and (B): (A) one or more kinds of plant extracts selected from hamamelis, button, ginger and quince, (B)
It is intended to provide a skin external preparation containing an acidic heteropolysaccharide derived from callus of a plant belonging to the genus Polyantes.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION The plant extract of the component (A) used in the present invention is obtained from a plant selected from hamamelis, button, ginger and quince.

[0013] The extract of these plants is obtained by drying one or more parts of the whole plant of each plant or its leaves, bark, roots, branches, etc. (hereinafter referred to as "the original substance") or without drying. After pulverization, it can be obtained by extracting with a solvent at room temperature or under heating or by using an extraction device such as a Soxhlet extractor. Here, the solvent used is not particularly limited, and examples thereof include water; primary alcohols such as methyl alcohol and ethyl alcohol; propylene glycol;
Liquid polyhydric alcohols such as 1,3-butylene glycol;
Examples include lower alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; known solvents such as ethyl ether and acetone. These solvents may be used alone or in combination.
More than one species can be used in combination.

As a specific example of a preferred extraction method from the drug substance, 100 g of dry pulverized material is added with 1000 ml of 50 v / v% ethanol, and extraction is performed for 3 days at room temperature with occasional stirring. The obtained extract is filtered, and the filtrate is allowed to stand at 5 ° C. for 3 days and then filtered again to obtain a supernatant. The plant extract obtained under the above-mentioned conditions may be used as it is as an extracted solution, but if necessary, may be used one which has been subjected to treatments such as concentration and filtration.

The plant extract of the component (A) can be used alone or in combination of two or more, and it is preferable to add 0.0001 to 20% by weight in the total composition in terms of dry solid content. Preferable, especially 0.0001 to 10% by weight, further 0.0
It is preferable to add 001 to 5% by weight because a higher effect of preventing skin aging can be obtained.

The component (B) used in the present invention is an acidic heteropolysaccharide (hereinafter referred to as "acidic polysaccharide") derived from callus of a plant belonging to the genus Polyanthes L. According to the method described in Japanese Patent Publication No. 10997, callus derived from a plant belonging to the genus Polyantes can be cultured and collected from the obtained culture. As a plant belonging to the genus Polyanthes, there is a tuberose (Polianthes tube)
rosa L. ) Is mentioned as a preferable example.

As a method of collecting the acidic polysaccharide, for example, in the case of tuberose, it can be carried out according to the following tissue culture method. That is, a part of a tuberose flower or the like was used as an explant in Linsmaier-skoo's basal medium, and 10 ⁻⁵ M auxin and 1 were added as plant hormones.
Add 0 ^-6 M cytokinin and add 3 as a carbon source.
After inducing callus using a medium to which saccharose is added, subculture is performed, and then shake culture is performed using a liquid medium containing the same components as the above callus culture medium. After that, cells are removed from the culture solution by centrifugation or filtration, the culture solution is concentrated using a rotary evaporator, etc., the concentrated solution is added with a solvent such as ethanol or acetone to cause precipitation, and the precipitate is freeze-dried. Thus, the acidic polysaccharide can be separated and obtained.

The acidic polysaccharide thus obtained is preferably added in an amount of 0.0001 to 20% by weight, particularly 0.001 to 10% by weight, more preferably 0.01 to 10% by weight, based on the total composition.
It is preferable that the composition be blended in a weight percentage, because a more sufficient effect of preventing skin aging can be obtained.

The external preparation for skin of the present invention is roughly classified into a medical external preparation for skin and a cosmetic composition according to its form. Examples of the medicated skin external preparation include various ointments containing a pharmaceutically active ingredient. Here, the ointment may be any of those based on an oily base and those based on an oil / water or water / oil emulsion type base. The oleaginous base is not particularly limited, and examples thereof include vegetable oils, animal oils, synthetic oils, fatty acids, and natural or synthetic glycerides, ceramides, and pseudoceramides. Further, the medicinal component is not particularly limited, for example, an analgesic anti-inflammatory, an antipruritic,
A disinfectant, an astringent, an emollient, a hormonal agent, and the like can be appropriately used as needed.

As the cosmetics, various forms such as water / oil, oil / water emulsion cosmetics, creams, cosmetic emulsions,
Skin cosmetics such as lotions, oily cosmetics, packs, lipsticks, foundations, skin cleansing agents, hair tonics, hair styling agents, hair nourishing agents and hair restorers can be used. In the case of cosmetics, in addition to the above essential components, components that are blended in ordinary cosmetics within a range that does not impair the effects of the present invention, such as oils, surfactants, pH regulators, ceramides, and pseudoceramides , Moisturizers, sterols, alcohols, chelating agents, anti-inflammatory agents, singlet oxygen scavengers, antioxidants, ultraviolet absorbers, preservatives, thickeners, pigments, fragrances, etc., if necessary. be able to.

The oil used here is not particularly limited, but for example, isopropyl palmitate, butyl stearate, isopropyl myristate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, cetyl lactate, 1-isostearoyl-
3-myristoyl glycerol, cholesteryl isostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-octyldodecyl myristate, neopentyl glycol di-2-ethylhexanoate, 2-octyldodecyl oleate Esters such as glycerol triisostearate, glyceryl di-paramethoxycinnamate-mono-2-ethylhexanoate;
2-hexyldecanol, oleyl alcohol, 2-octyldodecanol, patyl alcohol, cetanol,
Higher alcohols such as stearyl alcohol; hydrocarbons such as squalane, liquid paraffin, vaseline, solid paraffin; eucalyptus oil, peppermint oil, olive oil, camellia oil, macadamia nut oil, jojoba oil, avocado oil, lanolin, beef tallow, lard, egg yolk fat And other fats and oils; benzyl alcohol, phenylethyl alcohol, dextrin palmitate, d-δ-tocopherol, various silicone derivatives and the like.

The surfactant is not particularly limited, but for example, polyoxyethylene (hereinafter abbreviated as POE).
Hydrogenated castor oil, POE alkyl ether, POE branched alkyl ether, POE fatty acid ester, POE glycerin fatty acid ester, POE sorbitan fatty acid ester, POE sorbitol fatty acid ester, POE hardened castor oil alkyl sulfate, POE alkyl sulfate, polyglycerin fatty acid ester, Alkyl phosphate, POE alkyl phosphate, fatty acid alkali metal salt, sorbitan fatty acid ester, glycerin fatty acid ester, alkyl polyglucoside, polyethylene glycol fatty acid ester, α-monoisostearyl glyceryl ether, stearoyl methyl taurine sodium, POE lauryl ether phosphorus Sodium acid, ether-modified silicone, and the like.

The pH adjusting agent is not particularly limited, but examples thereof include metal oxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide, triethanolamine, isopropanolamine, diisopropanolamine, L-arginine and L-lysine. Basic amino acids, urea, ε-aminocaproic acid, sodium pyrrolidonecarboxylate, sodium hydrogenphosphate, sodium citrate, citric acid, lactic acid, succinic acid, tartaric acid, and the like. The external preparation for skin of the present invention is preferably adjusted to have a pH of 3 to 10 with these.

Ceramides are extracted from brain and skin,
It may be purified or synthesized by a chemical method. As such a synthesis method, for example, JP-A-59-7118, WO93 / 2281
The method described in the item can be used. Particularly preferred ceramides include N-oleoyl sphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, bovine brain ceramide and the like.

Pseudo-ceramides include, for example, JP-A-62 / 62.
And those manufactured according to the methods described in JP-A-228048 and JP-A-63-216852. Particularly preferred as pseudo-ceramides are the following formula (1)

[0026]

Embedded image

(Wherein R ¹ represents an alkyl group having 9 to 17 carbon atoms and R ² represents an alkyl group having 10 to 18 carbon atoms).

Examples of the sterols include cholesterol or a cholesterol derivative. As the cholesterol derivative, cholesteryl alkenyl succinate, cholestanol, carbon number 12 to 36, preferably carbon number 14 is used.
And cholesteryl esters having up to 28 saturated or unsaturated linear or branched hydrocarbon groups, and dehydrocholesterol. Among these, cholesteryl alkenyl succinate is synthesized by the production method described in JP-A-5-294989, for example, n-hexadecenyl succinic acid cholesteryl monoester, n-octadecenyl succinic acid cholesteryl ester. Examples thereof include monoesters. Examples of the cholesteryl ester include cholesteryl isostearate, cholesteryl 1,2-hydroxystearate, dehydrocholesterol, lanolin fatty acid cholesteryl, cholesteryl ricinoleate and the like. Of these, cholesteryl alkenylsuccinate and cholesterol are preferable. These sterols may be used alone or in combination of two or more.

Although the alcohols are not particularly limited, for example, lower alcohols such as ethanol; higher alcohols such as cetanol, stearyl alcohol, octyldodecanol; and polyhydric alcohols such as ethylene glycol, diethylene glycol, triethylene glycol and more. Polyethylene glycols, propylene glycol, dipropylene glycol, further polypropylene glycols, butylene glycols such as 1,3-butylene glycol and 1,4-butylene glycol, glycerin, diglycerin and further polyglycerins, Sugar alcohols such as sorbitol, mannitol, xylitol, maltitol, ethylene oxide of glycerins (hereinafter abbreviated as EO), propylene oxide (hereinafter PO Abbreviations) adducts, EO and PO adducts of sugar alcohols, monosaccharides such as galactose and fructose, and polysaccharides such as EO, PO adducts, maltose and lactose and their EO and PO adducts, and polyoxyethylene methyl And polyoxyalkylene alkyl glycosides such as glucoside (EO 10 or more).

Examples of the anti-inflammatory agent include glycyrrhizic acid and salts thereof, glycyrrhetinic acid and salts thereof, epsilon aminocaproic acid and salts thereof, allantoin, lysozyme chloride, guaizulene, methyl salicylate, γ-oryzanol, and the like, and in particular glycyrrhetinic acid. , Stearyl glycyrrhetinate, allantoin and epsilon aminocaproic acid are preferred.

As the singlet oxygen scavenger or antioxidant,
For example, carotenoids such as α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, lutein, zeaxanthin, inzeaxanthin, rhodoxanthin, capsanthin, and crocetin; 1,4-diazadiclooctane, 2,5-dimethylfuran , 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol, histidine, tryptophan, methionine, alanine or its alkyl ester, dibutyl. Tannins such as hydroxytoluene, butylhydroxyanisole, ascorbic acid, tannic acid, epicatechin, epigallocatechin, epicatechin gallate, and epigallogatechin gallate; flavonoids such as rutin Etc., and the like. Of these, carotene, tocopherol, ascorbic acid, tannic acid, dibutylhydroxytoluene, alanine, rutin, epicatechin gallate, and epigallocatechin gallate are preferred.

The external preparation for skin of the present invention can be produced by mixing the above-mentioned components (A) and (B) and optional components according to a conventional method.

[0033]

INDUSTRIAL APPLICABILITY The external preparation for skin of the present invention synergistically provides a moisturizing effect, a rough skin preventing / ameliorating effect, by using a plant extract of component (A) and an acidic polysaccharide of component (B) in combination. In addition, the effect of preventing and improving wrinkles is enhanced, and the effect of preventing skin aging is excellent.

[0034]

The present invention will be further described with reference to the following examples, but the present invention is not limited to these examples.

Production Example 1 (Production of Hamamelis extract) 100 g of a dried and ground product of Hamamelis leaf and bark
1000 ml of 50 v / v% ethanol was added, and extraction was performed for 3 days at room temperature with occasional stirring. The obtained extract was filtered, and the filtrate was allowed to stand at 5 ° C. for 3 days and then filtered again to obtain a supernatant.

Manufacture Example 2 (Manufacture of Button Extract) Manufacture was carried out in the same manner as in Manufacture Example 1 except that, in Manufacture Example 1, a dry ground product of button root bark was used in place of the dry ground product of Hamamelis. .

Production Example 3 (Production of Ginger Extract) In the same manner as in Production Example 1, except that the dried pulverized product of Hamamelis was replaced with the dried pulverized product of ginger rhizome. An extract of kyokyo was obtained.

Production Example 4 (Production of Sensiformia Extract) In the same manner as in Production Example 1, except that the dry ground product of Hamamelis was used in place of the dried ground product of Hamamelis, in the same manner as in Production Example 1. An extract was obtained.

These extracts have a dry solid content of 0.1.
It shall be manufactured so that it may become ~ 20%.

Example 1 An O / W cream having the composition shown in Table 3 was produced by the following production method, and the obtained cream was evaluated for its skin conductance, rough skin score and wrinkle formation inhibiting effect. The results are shown in Table 4.

(Production method) Oil phase component [(1), (2),
(4) to (9), (13), (14)] heated and dissolved at 80 ° C., and an aqueous phase component [(3), (11), (12), which was heated to 80 ° C. with stirring. (15) ~ (1
9) and (21)], and the mixture was emulsified, and then stirred and cooled to 50 ° C. Then components (10) and (20) are added,
Further cooling to room temperature with stirring gave an O / W cream.

(Test Method) Ten females aged 20 to 50, who have rough skin on the cheeks in winter, are used as test subjects, and different skin external preparations are applied to the left and right cheeks for 2 weeks. The test was performed on the day after the two-week application was completed for the skin conductance and the skin roughness score.

(1) Skin conductance: After washing the face with warm water of 37 ° C. and resting in a room at a temperature of 20 ° C. and a humidity of 40% for 20 minutes, the water content of the stratum corneum was measured by a skin conductance meter (IBS). It was measured at. The smaller the skin conductance value, the more rough the skin. The results were shown as average values.

(2) Rough skin score: Rough skin was visually observed and judged according to the following criteria. The score was shown as an average value.

[0045]

[Table 1] Score 0: No rough skin is observed. 1: Slight roughness is recognized. 2: Skin roughness is recognized. 3: Severe rough skin is recognized. 4: Severe rough skin is recognized.

(3) Wrinkle formation inhibitory effect: (Evaluation method) A skin external preparation (80 μm) was applied to hairless mice.
l) was applied. UV-B after 2 hours (1 MED or less)
, And immediately after that, a further sample was applied. This operation was performed five times a week for 16 weeks. Irradiation energy amount is UV-Radiometer (Tokyo op
Tal., VU-R-305 / 365 days), and measured so that the irradiation amount at one time is 1 MED or less.
The total irradiation amount was 100 mJ / cm ² with an energy amount of 8 mW / cm ² . After the application / irradiation for 16 weeks was completed, the frequency of the formed wrinkles was visually evaluated according to the following criteria (wrinkle index).
The results are shown as the average of 10 hairless mice.

[0047]

[Table 2] Standard (wrinkle index) 1: No wrinkles formed. 2: Wrinkles are slightly formed. 3: Some wrinkles are formed. 4: Wrinkles are firmly formed.

[0048]

[Table 3]

* 1: Pseudoceramide N- (2-hydroxy-3-hexadecyloxypropyl) -N-2-hydroxyethylhexadecanamide [in the general formula (1), R ¹ = C ₁₅ H ₃₁ , R ² = C ₁₆ H ₃₃ ] * 2: Silicone KF-96A (6 cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) * 3: Acid derived from callus of tuberose produced according to Example 1 of JP-A 64-10997. Heteropolysaccharide * 4: Hamamelis extract (Production Example 1: Dry solid content 1.0
%) * 5: Ginger extract (Production Example 3: dry solids 2.
0%) * 6: Button extract (Production Example 2: dry solid content 1.0%)

[0050]

[Table 4]

Example 2 A sunscreen cream having the composition shown below was produced by the following production method. The obtained cream was excellent in the effect of preventing skin aging.

[0052]

(Table 5) (Composition) (% by weight) (1) Pseudoceramide ^{* 7} 3.0 (2) Silicon-coated zinc oxide 7.0 (3) 2-ethylhexyl p-methoxycinnamate 2.0 (4) Vitamin E Acetate 0.2 (5) Cholesteryl isostearate 1.5 (6) Polyether-modified silicone ^{* 8} 2.5 (7) Methylpolysiloxane ^{* 9} 6.0 (8) Cyclic silicone ^{* 10} 12.0 (9) Magnesium sulfate 0.7 (10) Acidic polysaccharide ^{* 11} 5.0 (11) Glycerin 3.0 (12) Hamamelis ^{* 12} 1.0 (13) Preservative proper amount (14) Purified water balance * 7: N- (2-Hydroxy-3-hexadecyloxypropyl) -N-2-hydroxyethylhexadecanamide [In the general formula (1), R ¹ = C ₁₅ H ₃₁ and R ² = C ₁₆ H ₃₃ ] * 8: Silicone KF-6015 (manufactured by Shin-Etsu Chemical Co., Ltd.) * 9: Silicon KF-96A (6cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) * 10: Silicone SH-244, SH-245 or a mixture of SH-244 and SH-245 3: 2 (weight ratio) (manufactured by Toray Dow Corning Silicone Co., Ltd.) ) * 11: Acid heteropolysaccharide derived from tuberous callus produced in accordance with Example 1 of JP-A-64-10997 * 12: Hamamelis extract (Production Example 1: dry solid content 1.0%) )

(Production method) Oil phase component [(1), (3)-
(6)] is heated to 80 [deg.] C. to dissolve it, and the water phase components [(9) to (14)] are added thereto and uniformly mixed. After stirring and cooling to 50 [deg.] C., the components (2), ( 7) and (8) were uniformly mixed to obtain a sunscreen cream.

Example 3 A moisturizing essence having the following composition was produced by the following production method. The obtained moisturizing essence was excellent in skin aging prevention effect.

[0055]

(Table 6) (Composition) (% by weight) (1) Polyoxyethylene (40) hydrogenated castor oil 1.0 (2) acidic polysaccharide ^{* 13} 1.0 (3) urea 1.0 (4) ε-aminocapron Acid 0.3 (5) Sodium monohydrogen phosphate 0.75 (6) Citric acid 0.25 (7) Glycerin 10.0 (8) Ethanol 4.0 (9) Carboxyvinyl polymer ^{* 14} 1.5 (10 ) Potassium hydroxide 0.45 (11) Button extract ^{* 15} 1.0 (12) Preservative proper amount (13) Purified water residual amount * 13: Produced according to Example 1 of JP-A-64-10997 Tuberous callus-derived acidic heteropolysaccharide * 14: Carbopol 941 (manufactured by BF Goodrich Chemical) * 15: Button extract (Production Example 2: dry solid content 1.0%)

(Production method) Components (1) to (9) and (12)
~ (14) are uniformly stirred and dissolved, and the component (10) is added to the solution.
Add and disperse evenly. Furthermore, the component (11) is added,
I got a moisturizing essence.

Example 4 An oily foundation cream having the following composition was produced. The obtained foundation cream was excellent in the effect of preventing skin aging.

[0058]

[Table 7] (Composition) (% by weight) (1) Pseudoceramide ^{* 16} 3.0 (2) Silicone-coated zinc 5.0 (3) 2-Ethylhexyl p-methoxycinnamate 3.0 (4) Cholesteryl isostear Rate 3.0 (5) Polyether-modified silicone ^{* 17} 3.0 (6) Methyl polysiloxane ^{* 18} 5.0 (7) Cyclic silicone ^{* 19} 10.0 (8) Neopentyl glycol dicaprate 2.0 (9 ) Glycerin 2.0 (10) Titanium oxide 3.0 (11) Sericite 2.0 (12) Talc 3.0 (13) Red iron oxide 0.05 (14) Yellow iron oxide 0.10 (15) Black iron oxide 0.05 (16) Acidic polysaccharides ^{* 20} 1.0 (17) Sensiformia extract ^{* 21} 1.0 (18) Preservative proper amount (19) Perfume proper amount (20) Purified water balance * 16: N- (2) -Hydroxy-3-hexadecyloxypropyl) -N-2-hydroxy [In the general formula ^{(1), R 1 = C} 15 H 31, R 2 = C 16 H 33 ] ethyl hexadecanol cyanamide * 17: Silicone KF-6015 (Shin-Etsu Chemical Co., Ltd.) * 18: Silicone KF-96A (6 cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) * 19: Silicone SH-244, SH-245 or a mixture of SH-244 and SH-245 3: 2 (weight ratio) (manufactured by Toray Dow Corning Silicone Co., Ltd.) * 20 : Acid heteropolysaccharide derived from tuberous callus produced in accordance with Example 1 of JP-A-64-10997 * 21: Scutellaria sinensis extract (Production Example 4: dry solid content 0.5%)

(Production method) Oil phase component [(1) to (6),
(8)] was heated and dissolved at 80 ° C., and the aqueous phase components [(9), (16), (1
7), (18), (20)] and emulsified, and then 50
After stirring and cooling to ℃, the components (7), (10) to (1
5) and (19) were added, and the mixture was further cooled to room temperature with stirring to obtain an oily foundation cream.

Example 5 An O / W moisturizing emulsion having the composition shown below was produced by a conventional method. The obtained O / W type moisturizing emulsion was excellent in the effect of preventing skin aging.

[0061]

[Table 8] (Composition) (% by weight) (1) Pseudoceramide ^{* 22} 3.0 (2) Hamamelis extract ^{* 23} 0.5 (3) Button extract ^{* 24} 0.5 (4) Cetyl alcohol 1. 0 (5) Vaseline 2.0 (6) Squalane 5.0 (7) Dimethyl polysiloxane (6 cSt) 2.0 (8) Glycerin 4.0 (9) 1,3-Butylene glycol 2.0 (10) Poly Oxyethylene (20) sorbitan monooleate 0.5 (11) sorbitan monostearate 0.3 (12) acidic polysaccharide ^{* 25} 5.0 (13) n-hexadecenyl succinate cholesteryl monoester 1.0 (14) Stearyl glycyrrhetinate 1.0 (15) Tocopherol 1.0 (16) Succinic acid 0.55 (17) Sodium dihydrogen phosphate 0.9 (18) Purified water Remainder * 22: N- (2- Hydroxy-3-hexadecyloxypropyi ) -N-2-hydroxyethylhexadecanamide [in the general formula (1), R ¹ = C ₁₅ H ₃₁ , R ² = C ₁₆ H ₃₃ ] * 23: Hamamelis extract (Production Example 1: Dry solid content 1.0%) * 24: Button extract (Production example 2: Dry solid content 1.0%) * 25: Tuberose prepared according to Example 1 of JP-A No. 64-10997. Heteropolysaccharides from Callus in Japan

(Production method) Components (1), (4) to (7),
(10), (11) and (13) to (15) were dissolved by heating to 80 ° C., and the aqueous phase components [(2), (3),
(8), (9), (12), (16) to (18)] were added and mixed uniformly, and cooled to room temperature to obtain an O / W type moisturizing emulsion.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Tomoko Sadahiro 2-1-3 Fumika, Sumida-ku, Tokyo Inside Kao Institute of Stock Companies (72) Inventor Seiji Honma 2-1-3 Fumika, Sumida-ku, Tokyo Inside Kao Research Institute (72) Inventor Hideo Kimura 2-1-3 Fumika, Sumida-ku, Tokyo Inside Kao Research Institute

Claims (4)

[Claims] 1. The following components (A) and (B): (A) one or more plant extracts selected from hamamelis, button, ginger and quince, (B)
A skin external preparation containing an acidic heteropolysaccharide derived from a callus of a plant belonging to the genus Polyantes. 2. The external skin preparation according to claim 1, wherein the component (B) is an acidic heteropolysaccharide derived from callus of tuberose. 3. The content of the component (A) is 0.0001 to 20% by weight in terms of dry solid content.
The topical skin preparation according to the above. 4. The content of component (B) is from 0.0001 to
20% by weight of the external preparation for skin according to any one of claims 1 to 3.