JP3389071B2 - Cosmetics - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to skin moisturization, prevention / improvement of rough skin, prevention / improvement of skin swelling, loss of elasticity, dullness of complexion, excessive sebum, pores caused by bacteria and abnormal keratinization. Prevention and improvement of conspicuous and acne, prevention of wrinkle formation
The present invention relates to a cosmetic composition which is excellent in improving and preventing / improving spots and freckles, and is excellent in usability.

[0002]

2. Description of the Related Art In recent years, maintaining healthy and beautiful skin has become a serious concern for men and women of all ages. However, the skin is subtly affected by aging, temperature, humidity, ultraviolet rays, cosmetics, diseases, stress, eating habits, etc., and therefore various functions of the skin (prevention of loss of water etc. from the living body and constant body temperature). Various functions, such as the function to control the physical maintenance, the physical and chemical stimuli from the outside world and the function to protect the body from various bacteria, the function to maintain the elasticity of the skin and determine the surface morphology), the aging of the skin, etc. Trouble occurs.

Further, as described above, the skin trouble is caused by a change in the external environment (seasonal change, ultraviolet rays, etc.) and a function of the skin tissue due to internal and external factors acting on the living body such as changes in physiological functions due to aging and diseases. In addition to abnormalities, it is caused by skin thickening and parakeratosis induced by these.

The main attempts to prevent and ameliorate such skin troubles are to apply a synthetic or natural moisturizing component to prevent the skin from drying out and enhance the moisturizing ability of the skin, and to promote blood circulation by applying a blood circulation promoter. Have been made.

That is, free amino acids, organic acids, urea,
Inorganic ions, moisturizers such as polysaccharides such as hyaluronic acid, animal and plant extracts, vitamins and their derivatives, peptides and proteins are used to prevent the skin troubles mentioned above by using a medicated external preparation for skin and cosmetics. Attempts have been made to improve.

However, even if such a component is applied to the skin, its effect is low and it is temporary, and it has not been essential to prevent or ameliorate the skin trouble.

On the other hand, wrinkles, which are one of the skin troubles, occur due to aging due to aging, drying, ultraviolet rays and the like.
That is, dryness, changes in the surface morphology of the epidermis due to physical and chemical stimuli from the outside such as ultraviolet rays and aging, diseases, degeneration of tissues in the dermis due to stress, etc., in particular, collagen fibers are largely lost and degeneration of the dermis, The skin ages due to a decrease in subcutaneous adipose tissue, etc., which mainly causes wrinkle relaxation and loss of elasticity.

Conventionally, various compositions and methods have been proposed in order to suppress or treat such wrinkles due to aging (Japanese Patent Laid-Open No. 185005/1987).
JP-A-62-502546, JP-A-2-7215
No. 7, JP-A-2-288822, etc.). However, none of these showed a satisfactory wrinkle reducing effect.

In the case of skin spots and freckles, melanocytes are generally activated due to stimulation due to exposure to ultraviolet rays from sunlight, hormonal abnormalities, genetic factors, etc., and the melanin pigment synthesized there is present in the skin. It is thought to occur due to abnormal deposition.

Conventionally, in order to prevent such skin spots and freckles, L-ascorbic acid and its derivatives,
Hydroquinone, arbutin, kojic acid, cysteine,
Cosmetics containing melanin inhibitors such as glutathione and placenta extracts that act on keratinocytes to produce a whitening effect are used. However, these whitening effects are temporary, and a sufficiently satisfactory whitening effect has not yet been obtained.

[0011]

SUMMARY OF THE INVENTION Therefore, the object of the present invention is to provide a moisturizing effect, a preventive / improving effect for rough skin, a preventive / improving effect for skin swelling, loss of elasticity, dullness of complexion, excessive sebum, fungus and so on. It is excellent in the effect of preventing and improving the conspicuous pores and acne caused by abnormal keratinization, the effect of preventing and improving wrinkle formation, the effect of preventing and improving wrinkle formation, and the effect of preventing and improving spots and freckles, as well as excellent usability. To provide cosmetics.

[0012]

Under such circumstances, as a result of intensive studies, the present inventors have found that when a specific phosphate triester and a skin active ingredient are used in combination, the phosphate triester penetrates the skin active ingredient. As it promotes, the moisturizing effect of skin active ingredients, the effect of preventing and improving skin roughness, the effect of preventing and improving skin tone and elasticity, the complexion of complexion, etc., excess sebum, pores caused by bacteria and abnormal keratinization Preventive / ameliorating effects such as conspicuousness and acne, preventing / improving effect of wrinkle formation, preventing / improving effect of spots / freckles, preventing / improving conspicuous pores and acne caused by excess sebum, preventing / improving effect of wrinkle formation The present invention has been completed by finding that synergistically improved levels of., And (2) can be obtained, and that a cosmetic having an excellent feeling of use can be obtained.

That is, the present invention provides the following components (A) and (B): (A) General formula (1)

[0014]

[Chemical 8]

[Wherein R ¹ , R ² and R ³ are the same or different and represent a linear or branched alkyl group having 1 to 4 carbon atoms, and X, Y and Z are the same or different and have the same carbon number. 2 or 3
And a linear or branched alkylene group, wherein l, m and n are the same or different and each represents a number of 1 to 10. ] The phosphoric acid triester represented by the following, and (B) a skin active ingredient are contained, The cosmetics characterized by the above-mentioned are provided.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION The phosphoric acid triester of the component (A) used in the present invention is represented by the above general formula (1). In the general formula (1), the linear or branched alkyl group having 1 to 4 carbon atoms represented by R ¹ , R ² and R ³ is a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n- Examples thereof include a butyl group, an isobutyl group, a sec-butyl group, and a tert-butyl group. Of these, an alkyl group having 2 to 4 carbon atoms, particularly an ethyl group and an n group, are used because of their low irritation and good usability. -Butyl group is preferred. Further, R ¹ , R ² and R ³ may be the same or different from the viewpoint of performance, but it is preferable that the three are the same in terms of easiness of synthesis.

In the general formula (1), examples of the linear or branched alkylene group having 2 to 3 carbon atoms represented by X, Y and Z include ethylene group, trimethylene group and propylene group. However, ethylene group is preferable. Also,
The numbers 1 to 10 represented by l, m and n are XO,
Shows the average number of moles of YO and ZO added, (XO) _l , (YO) _m and (Z
The part of O) _n may be single or may have a distribution. l, m
And n is preferably a number of 1 to 4, particularly a number of 2 to 3.

As the phosphoric acid triester of component (A)
Is R in the general formula (1).¹, R ²And R³Is that
Each is an alkyl group having 2 to 4 carbon atoms, and X, Y and Z are
It is an ethylene group and l, m and n are each a number from 1 to 4
Are preferred.

The phosphoric acid triester (1) can be prepared by converting R ¹ O- (XO) ₁ -H, R ² O- (YO) _m -H and phosphorus oxyhalide such as phosphorus oxychloride according to a known method. R ³ O- (ZO) _n -H represented by three kinds (two or one of two or three of the three groups of the target are the same) alcohols directly or in the presence of a base. Can be synthesized by reacting all at once or sequentially.

The solvent may not be particularly used, but may be used. In this case, the solvent may be any one which is inert to the reaction and can dissolve phosphorus oxyhalide,
Although not particularly limited, for example, ether solvents such as tetrahydrofuran and dioxane, aliphatic hydrocarbons such as hexane, heptane, and octane, alicyclic hydrocarbons such as cyclopentane, cyclohexane, and methylcyclohexane, benzene, toluene, xylene, ethylbenzene, and the like. And aromatic hydrocarbons thereof. These solvents can be used alone or in combination of two or more. The amount of the solvent used is not particularly limited, but is generally such that the phosphorus oxyhalide concentration is 60% by weight or less, preferably 30% by weight or less.

As the base which can be used in this reaction,
Examples thereof include organic tertiary amines such as triethylamine, tributylamine and pyridine, and alkali metal hydroxides such as sodium hydroxide and potassium hydroxide. These bases can be used alone or in combination of two or more.

Specific examples of the phosphoric acid triester (1) as the component (A) include those shown below.

[0023]

[Chemical 9]

The phosphoric acid triester of the component (A) can be used alone or in combination of two or more kinds, and it is preferable to add it in an amount of 1 to 50% by weight in the whole composition, and particularly 2 to 25%.
It is preferable to add the composition in an amount of 5% by weight, more preferably 5 to 20% by weight.

The skin active ingredient of the component (B) used in the present invention means any activity on the skin, such as moisturizing effect, skin softening effect, whitening effect, anti-inflammatory effect, antioxidant effect, blood circulation promoting effect. , Has an effect of suppressing sebum secretion. Such active ingredients are not particularly limited as long as they are various active ingredients used in ordinary cosmetics, quasi drugs, pharmaceuticals, and the like, and examples thereof include ceramides, ceramide-like structural substances, amino acids, plant extracts, and whitening agents. , Anti-inflammatory agents, singlet oxygen scavengers, antioxidants, polysaccharides, water-soluble thickeners, alcohols, sterols, blood circulation promoters, sebum secretion inhibitors, antibacterial agents, keratolytic agents and the like.

Of these, ceramides are known compounds represented by the following general formula (2).

[0027]

[Chemical 10]

[In the formula, R ⁴ and R ⁵ are the same or different and each represents a linear or branched, saturated or unsaturated hydrocarbon group having 8 to 26 carbon atoms]

In the general formula (2), the hydrocarbon group represented by R ⁴ and R ⁵ is a straight or branched chain hydrocarbon group having 8 to 26 carbon atoms, which may be saturated or unsaturated. As, octyl, nonyl, decyl, dodecyl, undecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicodecyl, heneicosyl, docosyl, tricosyl, tetracosyl, pentacosyl, hexacosyl, nonenyl,
Decenyl, dodecenyl, undecenyl, tridecenyl,
Tetradecenyl, pentadecenyl, hexadecenyl, heptadecenyl, octadecenyl, nonadecenyl, eicosenyl, heneicocenyl, docosenyl, trichocenyl, tetracocenyl, pentacocenyl, hexacocenyl, nonadienyl, hexadecenyl, tridecadienyl, tridecadienyl, tridecadienyl, tridecadienyl, dodecadienyl, tridecadienyl, tridecadienyl, tridecadienyl, tridecadienyl, tridecadienyl, dodecadienyl, tridecadienyl, tridecadienyl , Heptadecadienyl, octadecadienyl, nonadecadienyl, eicosadienyl, heneicosadienyl, docosadienyl, tricosadienyl, tetracosadienyl, pentacosadienyl, hexacosadienyl, 2-hexyldecyl, 2-octylun Decyl, 2-decyltetradecyl, isostearyl group and the like can be mentioned. One or more hydroxyl groups may be substituted on these hydrocarbon groups.

R ⁴ is preferably a linear alkyl group having 15 to 23 carbon atoms, particularly pentadecyl, heptadecyl and tricosyl group, and R ⁵ is a linear saturated or unsaturated alkyl or alkenyl having 15 to 23 carbon atoms. The groups are particularly preferably pentadecyl, heptadecyl and pentadecenyl groups. Among the ceramides represented by the general formula (2), a particularly preferable compound is a compound in which R ⁴ and R ⁵ in the general formula (2) are each a group in the above particularly preferable range.

Further, examples of the ceramide-like structural material include those represented by the following general formulas (3) to (7).

[0032]

[Chemical 11]

[In the formula, R ⁶ represents a linear or branched saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ⁷ represents a linear or branched saturated or unsaturated hydrocarbon group having 9 to 25 carbon atoms. Represents an unsaturated hydrocarbon group, Y ¹ and Z ¹ represent a hydrogen atom or a hydroxyl group, a represents a number of 0 or 1, c represents an integer of 0 to 4, b and d represent 0 to 3 Indicates an integer]

[0034]

[Chemical 12]

[Wherein R ⁸ and R ⁹ are the same or different and each represents a linear or branched, saturated or unsaturated, optionally hydroxylated hydrocarbon group having 1 to 40 carbon atoms,
R ¹⁰ represents a linear or branched alkylene group having 1 to 6 carbon atoms or a single bond, R ¹¹ represents a hydrogen atom, 1 to 12 carbon atoms
Is a linear or branched alkoxy group or a 2,3-dihydroxypropyloxy group. However, when R ¹⁰ is a single bond, R ¹⁸ is a hydrogen atom. ]

[0036]

[Chemical 13]

[Wherein R ^8a represents an optionally hydroxylated hydrocarbon group having 4 to 40 carbon atoms, R ^10a represents a linear or branched alkylene group having 3 to 6 carbon atoms, and R 8
^11a represents a linear or branched alkoxy group having 1 to 12 carbon atoms. ]

[0038]

[Chemical 14]

[In the formula, R ⁸ , R ⁹ , R ^9a and R ^10a have the same meanings as described above. ]

[0040]

[Chemical 15]

[Wherein R ⁸ , R ⁹ and R ¹⁰ have the same meanings as described above, and R ^11b represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms, or 2,3-epoxypropyl. Indicates an oxy group. However, when R ¹⁰ is a single bond, R
^11b is a hydrogen atom. ]

These ceramide-like structural materials can be prepared by known methods [for example, Polish Journal of Chemistry (Po..J.Chem.) 52 , 1059 (19).
78); ibid. 52 , 1283 (1978); JP-A-54-
117421, 54-144308, 54-147937, 62-228048, 63-216852, and JP-A-8-3192.
63 gazette].

The number of carbon atoms represented by R ⁶ in the general formula (3) is 10
Examples of the straight chain or branched chain saturated or unsaturated hydrocarbon group of 26 to 26 include those having 10 to 26 carbon atoms in R ⁴ and R ⁵ , which are direct groups of 9 to 25 represented by R ^7. Examples of the chain or branched saturated or unsaturated hydrocarbon group include the above R
^And those having 10 to 26 carbon atoms in ⁴ and R ⁵ .
R ⁶ is preferably a straight chain saturated alkyl group having 12 to 18 carbon atoms, particularly preferably tetradecyl, hexadecyl group or octadecyl group, and R ⁷ is preferably a straight chain saturated alkyl group having 9 to 18 carbon atoms, particularly nonyl, Pentadecyl and heptadecyl groups are preferred. Among the ceramide-like structural substances represented by the general formula (3), a particularly preferable compound is a compound in which R ⁶ and R ^{7 in the} general formula (3) are groups in the above particularly preferable ranges. Is.

In the general formula (4), the linear or branched, saturated or unsaturated, optionally hydroxylated hydrocarbon group represented by R ⁸ and R ⁹ is Methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, heneicosyl, docosyl, nonacosyl, triacontyl, isostearyl, isoheptadecyl. Two
-Ethylhexyl, 1-ethylheptyl, 8-heptadecyl, 8-heptadecenyl, 8,11-heptadecadienyl, 2-heptylundecyl, 9-octadecenyl,
1-hydroxynonyl, 1-hydroxypentadecyl,
2-hydroxypentadecyl, 15-hydroxypentadecyl, 11-hydroxyheptadecyl, 11-hydroxy-8-heptadecenyl and the like can be mentioned.

R ⁸ is preferably a linear or branched alkyl or alkenyl group having 8 to 26 carbon atoms, for example, octyl, decyl, dodecyl, tetradecyl, hexadecyl, octadecyl, docosyl, triacontyl, isostearyl, 2-ethylhexyl, 2-heptyl undecyl, 9-octadecenyl and the like can be mentioned. Particularly preferred hydrocarbon group as R ⁸ is a linear or branched alkyl group having 12 to 22 carbon atoms, and examples thereof include dodecyl, tetradecyl, hexadecyl, octadecyl, docosyl and methyl-branched isostearyl groups.

R ⁹ is preferably a linear or branched alkyl or alkenyl group having ^{9 to} 25 carbon atoms, for example, nonyl, undecyl, tridecyl, pentadecyl, heptadecyl, heneicosyl, nonacosyl, isoheptadecyl, 1-ethylheptyl, 8- Heptadecyl, 8-heptadecenyl, 8,11-heptadecadienyl, 1-hydroxynonyl, 1-hydroxypentadecyl, 2-hydroxypentadecyl, 15-hydroxypentadecyl,
11-hydroxyheptadecyl and 11-hydroxy-
8-heptadecenyl and the like can be mentioned. Particularly preferred hydrocarbon groups as R ⁹ are linear and branched alkyl groups having 11 to 21 carbon atoms, such as undecyl, tridecyl,
Pentadecyl, heptadecyl, heneicosyl, methyl-branched isoheptadecyl group and the like can be mentioned.

R^TenIs a straight or branched chain having 1 to 6 carbon atoms
Represents an alkylene group or a single bond, and as an alkylene group
Is, for example, methylene, ethylene, trimethylene, tetrame
Tylene, pentamethylene, hexamethylene, 1-methyl
Ethylene, 1-methyltrimethylene, 2-methyltrimethyl
Ethylene, 1,1-dimethylethylene, 1-ethylethylene
1-methyltetramethylene, 2-ethyltrimethylene
And the like. R ^TenAs a straight chain having 1 to 6 carbon atoms
Alkylene groups are preferred, of which methylene and ethylene
And trimethylene are particularly preferred.

R ¹¹ represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-dihydroxypropyloxy group, and examples of the alkoxy group include methoxy, ethoxy, propoxy, butoxy and hexyloxy. , Octyloxy, decyloxy, 1-methylethoxy, 2-ethylhexyloxy and the like.
R ¹¹ is preferably a hydrogen atom, an alkoxy group having 1 to 8 carbon atoms or a 2,3-dihydroxypropyloxy group,
Of these, hydrogen atom, methoxy, ethoxy, propoxy,
Butoxy, 1-methylethoxy, 2-ethylhexyloxy and 2,3-dihydroxypropyloxy groups are particularly preferred.

Among the ceramide-like structural substances (4), particularly preferable compounds are R ⁸ , R ⁹ and R ^{10 in the} general formula (4).
And R ¹¹ are each a compound in which R ¹¹ is a group in the above particularly preferable range.

In the general formula (5), the number of carbon atoms represented by R ^8a is 4
Specific examples of the optionally hydroxylated hydrocarbon group of -40 include R ⁸ of the ceramide-like structural substance (4).
From which methyl, ethyl and propyl have been removed, and the same groups as R ⁸ are preferred. Specific examples of the linear or branched alkylene group having 3 to 6 carbon atoms represented by R ^10a include a group obtained by removing methylene and ethylene from the alkylene group exemplified in R ¹⁰ of the ceramide-like structural substance (4). Can be mentioned. As R ^10a , a linear alkylene group having 3 to 6 carbon atoms is preferable, and of these, trimethylene is particularly preferable. Examples of the linear or branched alkoxy group having 1 to 12 carbon atoms represented by R ^11a include the same groups as R ¹¹ of the ceramide-like structural substance (4), and the same groups are preferable.

In the general formula (6), R ⁸ , R ⁹ and R
^10a and R ^11a have the same meanings as described above, and the same groups are preferable.

Further, in the general formula (7), R ⁸ , R ⁹ and R
¹⁰ has the same meaning as described above, and R ^{11 b} represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms, or a 2,3-epoxypropyloxy group. R ⁸ , R ⁹
Specific examples of R ¹⁰ and R ¹⁰ include the same groups as the ceramide-like structural substance (4), and the same groups are preferable. R
Examples of the straight-chain or branched-chain alkoxy group having 1 to 12 carbon atoms of ^11b include the same groups as R ¹¹ of the ceramide-like structural substance (4), and the same alkoxy group as hydrogen atom R ¹¹ and 2,3 -Epoxypropyloxy groups are preferred.

These ceramides and ceramide-like structural substances may be used either individually or in combination of two or more, preferably 0.01 to 50% by weight in the total composition, particularly 0.01 If it is blended in an amount of 20 to 20% by weight, and further 0.1 to 10% by weight, it is more preferable from the viewpoints of feeling in use, moisturizing effect, effect of preventing and improving rough skin, effect of preventing and improving wrinkle formation, and stability.

Among the skin active ingredients of the ingredient (B) used in the present invention, examples of the antibacterial agent include sulfur, triclosan, trichlorocarbanilide, chlorhexine hydrochloride, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride. , Benzalkonium alkylphosphate, isopropylmethylphenol, benzoic acid, Photosensitizer No. 201 and resorcin. Of these,
Isopropylmethylphenol is particularly preferable. When adding these antibacterial agents, 0.0001 in the total composition
˜5% by weight, in particular 0.001 to 2% by weight, further 0.01
It is preferable to blend 1 to 1% by weight.

Among the skin active ingredients of the component (B) used in the present invention, examples of keratolytic agents include salicylic acid, N-acetylcysteine, lactic acid, citric acid, succinic acid, malic acid, alkylamine oxides. And benzoyl peroxide. Of these, salicylic acid and citric acid are particularly preferable. When blending these keratolytic agents, 0.01 to 10% by weight, especially 0.1
It is preferable to blend 1 to 1% by weight.

Among the skin-active ingredients of component (B) used in the present invention, amino acids or salts thereof include, for example, ornithine, tryptophan, lysine, arginine,
Histidine, canavanine, glutamic acid, aspartic acid, serine, alanine, glycine, leucine, isoleucine, proline, threonine, valine, methionine, cystine, cysteine, hydroxyproline, phenylalanine, tyrosine, hydroxylysine, trimethylglycine, sodium aspartate, aspartic acid Potassium, magnesium aspartate, calcium aspartate, sodium glutamate, potassium glutamate, magnesium glutamate, calcium glutamate, glutamate hydrochloride, cysteine hydrochloride, histidine hydrochloride, histidine acetate, histidine phosphate,
Lysine Hydrochloride, Lysine Acetate, Ornithine Hydrochloride, Ornithine Acetate, Tryptophan Hydrochloride, Arginine-Glutamate, Ornithine-Glutamate, Lysine-
Examples thereof include glutamate, lysine-aspartate, ornithine-aspartate, and ε-aminocaproic acid. Of these, arginine, lysine, hydroxylysine and histidine are preferable, and arginine is particularly preferable.

These amino acids or salts thereof may be used either individually or in combination of two or more, preferably 0.0001 to 15% by weight in the total composition, and more preferably 0.001 to 10% by weight. %, And further 0.01 to 8% by weight is preferable because it is more excellent in the moisturizing effect, the effect of preventing and improving wrinkle formation, the effect of preventing and improving rough skin, and the feeling of use and stability.

Among the skin active ingredients of the ingredient (B) used in the present invention, plant extracts include, for example, ashitaba, azuki bean, assenyaku, avocado, amacha, amachatsuru, altea, arteca, arnica, almond, aloe, Apricot, nettle, iris, fennel, turmeric,
Ages, Oogon, Oataku, Ouren, Barley,
Okra, Hypericum, Astragalus, Ononis, Dutch mustard, oyster, Cuckon, Valerian, Birch,
Cattail, chamomile, chamomile, oats, liquorice, raspberry, kiwi, kina, cucumber, kyonin,
Kukui nuts, gardenia, kumazasa, walnuts, keihi,
Mulberry, Gunjou, Gentian, Gentian, Ginkgo, Ginseng, Ginseng, Burdock, Sesame, Wheat, Comfrey, Rice, Sasanqua, Saffron, Hawthorn, Hawthorn, Shiitake, Geo, Cycon, Perilla, Linden, Shimotake, Peony, Shoal Kyou, ginger, ginger, birch, honeysuckle, horsetail, stevia, western pear,
Hawthorn, hawthorn, hazelnut,
Achillea millefolium, mint, sage, mallow, senkyu, senburi, mulberry bark, soybean, daisou, thyme, tea, clove, chinpi, evening primrose, camellia, camphor, spruce, corn, daffodil, spruce, spruce, corn, duckweed , Tomato, carrot, garlic, novara, stag beetle, barley winter, parsley, barefoot, pearl barley, peppermint, papaya, hamamelis, rose, cypress, sunflower, loquat, dandelion, grape, placenta, hazelnut, loofah, safflower, bodaiju, button , Hops, macadamia nuts, pine, matsukasa, horse chestnut, melissa, merlot, peach, bean sprouts, cornflower, palm, eucalyptus, yukinoshita, lily, yokuinin, wormwood, rye, peanut, lavender, apple Litchi, lettuce, lemon, Rengesou, rosemary, funnel, Roman chamomile, ShitoneChin蒿, agrimony, catalpa, dolabrata, Horutosou, cause, date, Senkishi, chickweed, duckweed,
Kawamura Mugwort, Ginkgo, Ginkgo, Chrysanthemum, Kumazasa,
Examples include extracts obtained from sorghum, forsythia and the like.

These plant extracts are obtained by drying or crushing whole plants or leaves of each plant, one or two or more places (hereinafter referred to as "protocol") of leaves, bark, roots, branches and the like. After that, it can be obtained by extracting with a solvent at room temperature or under heating, or by using an extraction device such as a Soxhlet extractor. Here, the solvent used is not particularly limited, and examples thereof include water; primary alcohols such as methyl alcohol and ethyl alcohol; propylene glycol;
Liquid polyhydric alcohols such as 1,3-butylene glycol;
Liquid fatty acid lower alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; known solvents such as ethyl ether and acetone; and these solvents may be used alone or in combination of two or more. it can. Of these, the extraction solvent is ethyl alcohol,
1,3-butylene glycol is preferred.

As a specific example of a preferable extraction method from the drug substance, 1000 g of 50 v / v% ethanol is added to 100 g of the dry ground product, and extraction is performed for 3 days at room temperature with occasional stirring. The obtained extract is filtered, the filtrate is left at 5 ° C. for 3 days and then filtered again to obtain a supernatant. The plant extract obtained under the above conditions may be used as it is as an extracted solution, but if necessary, it may be subjected to a treatment such as concentration and filtration.

These plant extracts can be used singly or in combination of two or more, and it is preferable to add 0.0001 to 20% by weight in the total composition in terms of dry solid content, and particularly, 0.0001 to 10% by weight, further 0.000
When 1 to 5% by weight is blended, moisturizing effect and prevention of wrinkle formation
It is preferable because it is effective in improving, preventing and improving rough skin, preventing and improving skin swelling, loss of elasticity, dull complexion, and preventing and improving spots and freckles. .

Among these plant extracts, especially chamomile, tea, cuckoo, clove, licorice, loquat, spruce, ginseng, peony, hawthorn, barley winter, ginger, matsukasa, mulberry bark, magnolia, halibut Synergistic whitening is achieved by using one or more plant extracts selected from extracts of linseed, assenyaku, yellow gon, aloe, altea, spirea, Dutch pepper, kina, comfrey, rosemary and funnel. The effect is enhanced, and it is possible to effectively prevent and improve spots and freckles, as well as a moisturizing effect and prevention of rough skin.
The improvement effect can be remarkably enhanced.

Among these, the chamomile extract is the chamomile [Matricaria chamomilla
L. (Compositee)] flower can be obtained as an extract by extracting with water or a hydrophilic organic solvent such as methanol, ethanol, propanol, propylene glycol, 1,3-butylene glycol, or a mixed solvent thereof. The extract can be dried and obtained in the form of a dry powder. Further, it is extracted with a hydrophilic organic solvent such as castor oil, persic oil, liquid paraffin, soybean oil, isopropyl myristate, lower fatty acid triglyceride, intermediate fatty acid triglyceride, sunflower oil, neopentyl glycol dicaprate, squalane, or a mixed solvent thereof. Can be obtained. In the present invention, 1 of the chamomile extract thus obtained
It is possible to use one kind or a combination of two or more kinds.

The chamomile extract generally contains azulene, chamazulen, umbelliferone, 7-methoxycoumarin, matricin, matricalin, taraxasterol, lupeol, apiin, chroman, spiroether and the like. Here, as a preferable extraction method of chamomile, the following method can be mentioned, for example.

The chamomile flowers are dried and chopped. Squalane is added to it, and the mixture is immersed from room temperature to 50 ° C. with occasional stirring and then squeezed to obtain an extract. The extract is filtered to give a chamomile extract.

When these plant extracts are used, from the viewpoint of whitening effect and stability, it is preferable to add 0.00001 to 5% by weight in terms of dry solid content in the entire composition, and particularly, it is preferable that the content is 0. 0005-3% by weight, further 0.001-2
When it is blended in a weight percentage, a sufficient whitening effect, a moisturizing effect, an effect of preventing and improving rough skin, and a feeling of use and stability are excellent, which is preferable.

Among the plant extracts, horsetail, gentian, hamamelis, peony, buttercup, caterpillar,
Synergistically, when one or more kinds selected from asunaro, orthosaw, Hiki-Okoshi and Pheasant's extract are used,
The skin aging prevention effect is enhanced, and wrinkle formation is effectively prevented.
Not only can it be improved, but the moisturizing effect and rough skin preventing / ameliorating effect can be remarkably enhanced.

When using these plant extracts, 0.00001 to 20 in the total composition is calculated in terms of dry solids.
It is preferable to add the compound in an amount of 0.001 to 10% by weight.
%, Further 0.0001 to 5% by weight, a sufficient effect of preventing and improving wrinkle formation, skin firmness, and deterioration of elasticity,
It is preferable because it has an effect of preventing and improving dullness of complexion, a moisturizing effect, an effect of preventing and improving rough skin, and is excellent in feeling of use and stability.

In the component (B) used in the present invention, the whitening agent is not particularly limited as long as it is used in ordinary cosmetics, and for example, L-ascorbic acid and its derivative, hydroquinone derivative, Examples include kojic acid and its derivatives, placenta extract and the like.

Of these, ascorbic acid and its derivatives are not particularly limited, and examples include L
-L, which is a monovalent metal salt of ascorbic acid phosphate
-Ascorbic acid phosphoric acid sodium salt, L-ascorbic acid phosphoric acid potassium salt, divalent metal salt L-ascorbic acid phosphoric acid magnesium salt, L-ascorbic acid phosphoric acid calcium salt,
L-ascorbic acid phosphoric acid aluminum salt which is a trivalent metal salt, L-ascorbic acid sulfuric acid sodium salt which is a monovalent metal salt of L-ascorbic acid sulfuric acid ester, L-ascorbic acid sulfuric acid potassium salt and divalent L-ascorbic acid sulfate potassium magnesium salt, which is a metal salt, L-ascorbic acid sulfate calcium salt, a trivalent metal salt, L-ascorbic acid sulfate aluminum salt, and L which is a monovalent metal salt of L-ascorbic acid. -Ascorbic acid sodium salt, L
-Ascorbic acid potassium salt, divalent metal salt L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, trivalent metal salt L-ascorbic acid aluminum salt and the like can be mentioned as preferable ones.

The hydroquinone derivative is not particularly limited, and examples thereof include a condensate of hydroquinone and a sugar, a condensate of a hydroquinone and an alkylhydroquinone obtained by introducing one alkyl group having 1 to 4 carbon atoms into a sugar, and the like. Among them, preferred examples include arbutin and the like.

The kojic acid and its derivatives are not particularly limited, and examples thereof include kojic acid, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, and kojic acid monocinnamo. Preferable examples thereof include monoesters such as ates and kojic acid monobenzoate, diesters such as kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, and kojic acid dioleate.

As the placenta extract, those which are commercially available as a water-soluble placenta extract and which are generally used as a raw material for cosmetics can be used. For example, the placenta of a mammal such as cow, pig or human can be washed, blood removed, Examples thereof include those obtained by extracting water-soluble components through steps such as crushing and freezing, and further removing impurities.

Of these whitening agents, especially arbutin,
Kojic acid and water-soluble placenta extract are preferred.

These whitening agents may be used either individually or in combination of two or more. From the viewpoints of whitening effect, emulsion stability and feeling of use, 0.01 to 30% by weight is added to the entire composition. It is particularly preferable that 0.01 to 10% by weight, more preferably 0.01 to 5% by weight, be added because a sufficient whitening effect can be obtained and the feeling of use and stability are excellent.

Among the skin active ingredients of component (B) used in the present invention, examples of the anti-inflammatory agent include glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, isopropylaminocaproic acid and its salts, allantoin, and chloride. Examples thereof include lysozyme, guaiazulene, methyl salicylate, γ-oryzanol, and the like. Of these, glycyrrhetinic acid, stearyl glycyrrhetinate, and epsilon aminocaproic acid are preferable.

These anti-inflammatory agents may be used either individually or in combination of two or more, and preferably 0.001 to 5 in the total composition.
It is preferably blended in an amount of 0.01% by weight, particularly preferably 0.01 to 2% by weight, and more preferably 0.01 to 1% by weight, because a high effect of preventing and improving wrinkle formation is obtained, and it is preferable in terms of usability and stability.

Among the active ingredients of component (B) used in the present invention, examples of the singlet oxygen scavenger or antioxidant include α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, lutein, zeaxanthin. Carotenoids such as isosetaxanthin, rhodoxanthin, capsanthin and crocetin; 1,4-diazacyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol, histidine, tryptophan, methionine, alanine or an alkyl ester thereof; dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid, tannic acid,
Examples thereof include tannins such as epicatechin, epicarocatechin, epicatechin gallate, and epicarocatechin gallate, flavonoids such as rutin, and the like. Among these, carotene, tocopherol, ascorbic acid, tannic acid,
Epicatechin gallate and epicarocatechin gallate are preferred.

These singlet oxygen scavengers or antioxidants may be used either individually or in combination of two or more, preferably 0.001 to 5% by weight based on the total composition, and particularly preferably 0.1. When it is blended in an amount of 01 to 2% by weight, more preferably 0.01 to 1% by weight, a high effect of preventing and improving wrinkle formation can be obtained, and it is preferable from the viewpoint of feeling in use and stability.

Of the skin-active ingredients of the component (B) used in the present invention, the polysaccharide is preferably an acidic polysaccharide, and for example, it belongs to the genus Polyanthes according to the method described in JP-A-64-10997. Callus derived from the plant to which it belongs can be cultured and harvested from the resulting culture. As a plant belonging to the genus Polyanthes, there is a tuberose (Polianthes tuberosa).
L. ) Is mentioned as a preferred example, and as the acidic polysaccharide, it is particularly preferable to use a modified heteropolysaccharide derived from callus of tuberose.

As a method for collecting the acidic polysaccharide, for example, in the case of tuberose, the following tissue culture method can be used. In other words, 10 ^-5 M auxin and 10 ^-6 M cytokinin as plant hormones were added to a Linsamaier-skoo's basal medium as a part of a tuberose flower as an explant, and 3% saccharose was further added as a carbon source. After inducing callus using the added medium, subculture is performed, and further shake culture is performed using a liquid medium containing the same components as the above callus culture medium.
After that, cells are removed from the culture solution by centrifugation or filtration, the culture solution is concentrated using a rotary evaporator, etc., the concentrated solution is added with a solvent such as ethanol or acetone to cause precipitation, and the precipitate is freeze-dried. Thus, the acidic polysaccharide can be separately obtained.

The acidic polysaccharide thus obtained is preferably added in an amount of 0.0001 to 30% by weight, particularly 0.001 to 20% by weight, more preferably 0.01 to 15% by weight in the total composition.
When blended in a weight percentage, a high moisturizing effect, a rough skin preventing / ameliorating effect, a stain / freckless preventing / ameliorating effect can be obtained, and it is also preferable from the viewpoint of feeling in use and stability.

Among the skin-active ingredients as the component (B) used in the present invention, examples of the water-soluble thickener include acrylic acid polymers and water-soluble polymers. Among these, the acrylic acid-based polymer forms a gel by neutralizing with an alkaline agent. Therefore, the acrylic acid-based polymer is not particularly limited as long as it forms a gel by neutralizing with an alkali agent, and those generally referred to as water-soluble alkali thickening type polymers are used. As such an acrylic acid-based polymer,
For example, B. F. Goodrich Compan (BFGoodrich Compan
Carbopol 90 available from y)
7, 910, 934, 934-P, 940, 941, 9
54, 980, 981, 1342, ETD2020, E
TD2050, 1382, 2984, 5984 etc., Pemulen (Pemulen) TR-1, TR-2 etc., Lipo Company (Lip
o Hypa (Hypa) available from Chemicals Inc.
m) SA-100H, SR-150H, SS-201,
AQUPEC HV-501, HV-504, HV-5 commercially available from Sumitomo Seika, such as QT-100.
00, and the like, such as Sepigel (SEPIGEL) 305 and 501, which are commercially available from Seppic Inc. Among these, particularly preferred acrylic acid-based polymers include Carbopol 941, 981, 940, 98.
0, 1342, 1382; Pemulan TR-1, TR-
2, Sepigel 305 can be mentioned.

These acrylic acid-based polymers can be used alone or in combination of two or more, and the blending amount may be appropriately determined depending on the type of the polymer and the like.
It is preferable to add 0.1 to 20% by weight to the total composition,
Particularly, it is preferable to add 0.1 to 10% by weight, and further 0.15 to 5% by weight, because it is excellent in the moisturizing effect, feeling in use and stability.

As the alkaline agent for neutralizing the acrylic acid type polymer and gelling it, inorganic bases such as sodium hydroxide, potassium hydroxide and ammonium hydroxide and organic acids such as triethanolamine and L-arginine can be used. Examples include salt. These alkaline agents are used in an amount of 0.1 to 3 parts by weight, especially 0.1% by weight, based on 1 part by weight of the acrylic acid polymer.
It is preferable to use 5 to 2 parts by weight.

The water-soluble polymer is not particularly limited as long as it is used in ordinary cosmetics and the like, and for example, guar gum, quince seed, carrageenan, locust bean gum, gum arabic, tragacanth, pectin, mannan, Starch, sodium alginate, sodium hyaluronate, xanthan gum, pullulan dextran, curdlan, collagen, keratin, casein, albumin, gelatin, chondroitin sulfate, chitin, cationized cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, Hydroxypropyl trimethyl ammonium chloride ether, carboxymethyl cellulose, dextran sulfate, carboxymethyl carboxy Emissions, soluble starch, carboxymethyl starch, propylene glycol alginate, polyvinyl alcohol, polyvinyl pyrrolidone, sodium polyacrylate, polyvinyl methyl ether, and the like. Of these, xanthan gum, sodium hyaluronate, hydroxyethyl cellulose and the like are particularly preferable.

These water-soluble polymers can be used alone or in combination of two or more, and the total composition is 0.01 to
It is preferable to add 5.0% by weight, particularly 0.05-
A blending amount of 3.0% by weight, and further 0.05 to 0.3% by weight, is preferable because it is excellent in moisturizing effect, feeling of use and stability.

Among the skin active ingredients of the component (B) used in the present invention, examples of alcohols include higher alcohols and polyhydric alcohols. Examples of higher alcohols include benzyl alcohol, isocetyl alcohol, isostearyl alcohol, behenyl alcohol, hexadecyl alcohol, phenylethyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, 2-octyldodecanol, batyl alcohol, 2-hexyldecanol and the like. However, cetanol and stearyl alcohol are particularly preferable.

These higher alcohols may be used either individually or in combination of two or more, and may be 0.01% in the total composition.
It is preferable to blend 20 to 20% by weight, particularly 0.05 to 1
A blending amount of 0% by weight, and further 0.1 to 5% by weight, is preferable because the moisturizing effect, the rough skin preventing / ameliorating effect, the wrinkle forming preventing / ameliorating effect are enhanced, and the usability and stability are more excellent.

The polyhydric alcohols are not particularly limited, but for example, polyglycerin such as glycerin, diglycerin, triglycerin and tetraglycerin, ethylene glycol, 1,3-propanediol, glucose, maltose, maltitol, Sucrose, fructose, xylitol, sorbitol, maltotriose,
Examples thereof include threitol, erythritol, starch-decomposing sugar reducing alcohol, sorbit, polyoxyalkylene alkyl glycoside and the like. Of these, glycerin and 1,3-propanediol are particularly preferable.

These polyhydric alcohols may be used either individually or in combination of two or more, and may be used in an amount of 0.0
It is preferable to add 01 to 50% by weight, particularly 0.01
When it is blended in an amount of -30% by weight, and further 0.1-20% by weight, the moisturizing effect, the rough skin preventing / ameliorating effect, the wrinkle formation preventing / ameliorating effect are enhanced, and the usability and stability are also excellent, which is preferable.

Among the skin active ingredients of the component (B) used in the present invention, examples of sterols include cholesterol, cholesteryl isostearate, provitamin D ₃ , campesterol, stegmasteranol, stegmasterol, 5-dihydro. Cholesterol, α-
Spinasterol, paristerol, clionasterol, γ-sitosterol, stegmasterenol, salgasterol, apenasterol, ergostanol, sitosterol, corvisterol, chondrilasterol, polyferrasterol, haliclonasterol, neosvongosterol, fucosterol. , Aptostanol, ergostadienol, ergosterol, 22
-Dihydroergosterol, brassicasterol, 2
4-methylenecholesterol, 5-dihydroergosterol, dehydroergosterol, fungisterol, cholestanol, coprostanol, dimosterol, 7-hetcholesterol, latosterol, 22-
Dehydrocholesterol, β-sitosterol, cholestatriene-3β-ol, coprostanol, cholestanol, ergosterol, 7-dehydrocholesterol, 24-dehydrocholestredan-3β-ol,
Examples thereof include equilenin, equilin, estrone, 17β-estradiol, androst-4-ene-3β, 17β-diol, dehydroebiandrosterone, cholesterol alkenylsuccinate (JP-A-5-294989). Of these, cholesterol, cholesteryl isostearate, and cholesteryl alkenylsuccinate are particularly preferable.

These sterols may be used either individually or in combination of two or more, and may be used in an amount of 0.001 in the total composition.
It is preferable to add 50% by weight, especially 0.005%
It is preferable to add 30% by weight, and further 0.01 to 20% by weight, since the moisturizing effect, the rough skin preventing / ameliorating effect, the wrinkle forming preventing / ameliorating effect are enhanced, and the usability and stability are excellent.

Among the skin active ingredients of the component (B) used in the present invention, the blood circulation promoter is usually a cosmetic,
Agents used in quasi drugs, pharmaceuticals, etc. can be used as they are. Particularly, as the compound, JP-A-62-62
-87506, a vasodilator, an esterified product of vitamin E, a nicotinic acid ester or an orotic acid ester, and a peripheral circulation promoting agent, vitamin E, described in JP-A-62-195316. The esterification product, acetic acid ester, or succinic acid ester of nicotinic acid amide, methyl nicotinate, or the like is used.

Further, as plant extracts having a blood circulation promoting effect, extracts specified in the extra edition 6 of the special issue of Fragrance Journal published in 1986 and the extra edition 1 of special issue of Fragrance Journal issued in 1979, for example, Arnica, Hawthorn, Quercus, Salvia, Bodaiju, Ginseng, Tosho, Mannenrow, Hypericum, Ginkgo, Melissa, Ononis, horse chestnut, senburi, garlic, chamomile, sim, mint, nettle,
Capsicum, ginger, hop, horse chestnut, lavender, carrot, mustard, kay, pine, senkyu,
Elderberry, Yamageri, Pyrrha, Cochlear, Button, Bayberry, Dokudami, Kohone, Shibaki, Daffodil,
Used with plant extracts such as Gubijinso, Gentiana, Grape, Hamaboufu, Daidai, Yuzu, Shobu, Natsumikan, Hamamelis, Maryloat, Fennel, Peppermint, Peonies, Eucalyptus, Wormwood, Triticum officinalis, Rice, Clara, Ginger, Clove. To be

These plant extracts are obtained, for example, by extracting leaves, roots, stems, flowers, etc. of these plants with water and / or a hydrophilic organic solvent to obtain an extract; Then, a method of obtaining a powder by freeze-drying, spray-drying, distillation under reduced pressure and the like can be mentioned. As a hydrophilic organic solvent,
Examples include methanol and ethanol, with ethanol being particularly preferable. These solvents may be used alone or in combination of two or more kinds, or water and these hydrophilic organic solvents may be mixed and used. The amount of these extraction solvents used is not particularly limited, and the obtained extract can be used as it is, or can be further concentrated and purified before use.
Further, commercially available products of these plant extracts can also be preferably used.

Among these, tocopherol nicotinate, tocopherol acetate, and nicotinic acid amide are preferable as the compound, and as the plant extract, senburi extract, Hypericum perforatum extract, ginkgo biloba extract, arnica extract, quinque extract, hamamelis extract, ginseng essence extract. , Horse chestnut extract, gall nuts extract, salvia extract, hamaboufu extract, salamander extract, rice germ oil, bodige extract, ginkgo tincture and clove extract are preferable.

These blood circulation promoters can be used alone or in combination of two or more, and usually 0.001 to 10 in the total composition as an active ingredient (as a dry solid in the case of a plant extract). It is preferably blended in an amount of 0.01% by weight, particularly 0.01 to 5% by weight, more preferably 0.05 to 3% by weight, to prevent and improve the skin's elasticity, elasticity, dull complexion, moisturizing effect, and rough skin. It is preferable because it is more effective in preventing and improving wrinkles, preventing and improving wrinkle formation, and preventing and improving spots and freckles, and is more excellent in usability and stability.

Among the skin active ingredients of the ingredient (B) used in the present invention, examples of sebum secretion inhibitors include “Fragrance Journal No. 10 (1994).
Years) ”and generally used as sebum secretion inhibitors, anti-androgen agents, crude drug extracts, astringents, and other components can be used.

Specifically, the antiandrogens include
Examples thereof include oxendron, 17-α-methyl-β-nortestosterone, chromadinone acetate, cyproterone acetate, spironolactone, hydroxyflutamide, estradiol, ethinyl estradiol.

Examples of the herbal extracts include walnut leaves,
Ougon, sage, hops, rosemary, Hypericum, peppermint, chamomile, hemp bird, yellow ream, yellow oak, yellow liquor, heavy drug, rind, carrot, peony, toussi, propolis,
Examples include extract extracts such as taxia, tannin, hamamelis, button, birch tar, royal jelly and kobo extract.

Examples of the astringent include zinc sulfocarbolate, zinc oxide, aluminum hydroxychloride, allantoin dihydroxyaluminum and the like.
In addition, vitamin B ₆ , 13-cis-retinoic acid, vitamin E, glycyrrhetinic acid, salicylic acid, nicotinic acid, calcium pantothenate, dipotassium azelate, 10-hydroxyundecanoic acid, 12-hydroxystearic acid, etc. are also sebum secretion inhibitors. Can be used.

Of these, estradiol, zinc sulfocarbonate, zinc oxide, royal jelly, 10-hydroxyundecanoic acid and 12-hydroxystearic acid are particularly preferable.

When these sebum secretion inhibitors are blended, 0.01 to 10% by weight, especially 0.1 to 5% by weight of the total composition is used.
It is preferably blended in a weight percentage (as a dry solid content in the case of a crude drug extract).

As the skin active ingredient of the component (B), one of the above various components may be used alone, or two or more thereof may be used in combination.
The total amount is 5 to 60% by weight in the whole composition, especially 10 to 4
It is preferably 0% by weight.

Further, in the cosmetic of the present invention, in addition to the above-mentioned essential components, various optional components which are usually used in cosmetics, quasi-drugs, pharmaceuticals and the like are added, if necessary, within a range that does not impair the effects of the present invention. It can be blended appropriately. Examples of such optional components include purified water, ethanol, surfactants, oily components, silicones, fluorine-based oil agents, UV protective agents, powders, oil gelling agents, film forming agents, softening agents, pH adjusting agents. Etc.

Specifically, the surfactant is not particularly limited, and a nonionic surfactant, an anionic surfactant,
Any amphoteric surfactant or the like can be preferably used. As the nonionic surfactant, for example, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, fatty acid monoglyceride, poly Oxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil alkyl sulfate, polyoxyethylene castor oil, polyoxyethylene alkyl sulfate, polyglycerin fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, alkyl phosphate ester, polyoxy Examples thereof include ethylene alkyl phosphate ester, fatty acid alkali metal salt, alkyl glyceryl ether and the like.

As the anionic surfactant, a linear or branched alkylbenzene sulfonate, a linear or branched alkyl or alkenyl ether sulfate, an alkyl or alkenyl sulfate having an alkyl group or an alkenyl group, an olefin Sulfonate, alkane sulfonate, unsaturated fatty acid salt, alkyl or alkenyl ether carboxylate, α-sulfo fatty acid salt or ester having an alkyl group or alkenyl group, N-acyl having an acyl group and a free carboxylic acid residue Examples thereof include amino acid type surfactants and phosphoric acid mono- or diester type surfactants having an alkyl group or an alkenyl group.

Examples of the zwitterionic surfactant include imidazoline-based amphoteric surfactants having an alkyl group, an alkenyl group or an acyl group, carbobetaine-based, amidobetaine-based, sulfobetaine-based, hydroxysulfobetaine-based or amidosulfobetaine-based amphoteric surfactant. Examples thereof include surfactants. Further, polyether-modified silicone, JP-A-4-1-1
It is also possible to use a silicone-containing surfactant such as the siloxane derivative described in JP-A-08795, or a surfactant having a perfluoroalkyl group.

When blending these surfactants,
It is preferable to add 0.01 to 20% by weight, particularly 0.1 to 5% by weight in the total composition.

The oily component is not particularly limited and may be volatile or non-volatile. For example, solid or liquid paraffin, petrolatum, crystal oil, ceresin, ozokerite, montan wax, squalane, squalene, and other hydrocarbons. Kinds; Eucalyptus oil, peppermint oil, camellia oil, macadamia nut oil, avocado oil, beef tallow, lard,
Horse fat, egg yolk fat, olive oil, carnauba wax, lanolin, jojoba oil; glycerin monostearate,
Glycerin distearate, glycerine monooleate, isopropyl palmitate, isopropyl stearate, butyl stearate, isopropyl myristate, neopentyl glycol dicaprate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, myristyl lactate ,
Diisopropyl adipate, cetyl myristate, cetyl lactate, 1-isostearoyl-3-myristoyl glycerol, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-octyldodecyl myristate, di-2-ethylhexanoic acid Neopentyl glycol, 2-octyldodecyl oleate, glycerol triisostearate, di-paramethoxycinnamic acid-
Ester oils such as glyceryl mono-2-ethylhexanoate; higher fatty acids such as stearic acid, palmitic acid and oleic acid. When these oily ingredients are blended, 0.001 to 50% by weight, especially 0.1% by weight of the total composition.
It is preferable to add 005 to 30% by weight.

The silicones are not particularly limited as long as they are usually blended in cosmetics, and include, for example, octamethyl polysiloxane, tetradecamethyl polysiloxane, methyl polysiloxane, highly polymerized methyl polysiloxane and methyl. In addition to phenylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and other methylpolycyclosiloxanes, trimethylsiloxysilicic acid, and further alkyl-modified silicones, polyether / alkyl-modified silicones, alkylglyceryl ether-modified silicones, Kaihei 6-72
Examples thereof include modified silicones such as modified organopolysiloxane described in Japanese Patent No. 851. When these silicones are compounded, it is preferable to compound them in an amount of 0.001 to 50% by weight, particularly 0.005 to 30% by weight, based on the total composition.

As the fluorinated oil agent, perfluoropolyether which is a perfluoroorganic compound which is liquid at room temperature,
Fluorine-modified silicone is preferable, and examples thereof include perfluorodecalin, perfluoroadamantane, perfluorobutyltetrahydrofuran, perfluorooctane, perfluorononane, perfluoropentane, perfluorodecane, perfluorododecane, fluorine-modified silicone, and general formula (8 )

[0114]

[Chemical 16]

(In the formula, R ¹² , R ¹⁴ , R ¹⁵ and R ¹⁶ may be the same or different and each represents a fluorine atom, a perfluoroalkyl group or a perfluoroalkyloxy group, and R ¹³ represents a fluorine atom or a perfluoroalkyloxy group. A fluoroalkyl group, wherein a ₁ , b ₁ and c ₁ have a molecular weight of 500 to 100,0
Indicates a number of 0 or more that is 00. However, a ₁ = b ₁ = c
₁ = 0 never. ) And perfluoropolyether. Here, the perfluoro groups shown in parentheses do not have to be arranged in this order, and random polymerization or block polymerization may be used. As such a perfluoropolyether, a liquid one having a viscosity of 5 to 5,000 cs (centistokes) is particularly preferable. For example, the following general formula (9)

[0116]

[Chemical 17]

(In the formula, d ₁ and e ₁ have a molecular weight of 500 to
The number is 10,000, and d ₁ / e ₁ is 0.2 to 2
Is. ) FOMBLIN HC-04 (average molecular weight 1,500), HC-25 (same 3,200)
And HC-R (6,600) of the same (above manufactured by Montefloss) and the following general formula (10)

[0118]

[Chemical 18]

(In the formula, f ₁ represents a number of 4 to 500.)
Demnum S-20 represented by (weight average molecular weight 25,0
00), the same S-65 (the same 4,500), the same S-100.
(5,600) and S-200 (8,400)
Commercial products such as those manufactured by Daikin Industries, Ltd. can be used.

As the fluorine-modified silicone, for example, one having one or more of the structural units represented by the following general formulas (11) to (14) and the structural unit represented by the following general formula (15). Can be mentioned.

[0121]

[Chemical 19]

[In the formula, Rf and Rf ′ may be the same or different and are a linear or branched perfluoroalkyl group having 1 to 20 carbon atoms or the following formula: H (CF ₂ ) _g 1-(g
₁ represents an integer of ₁ to 20) and represents a ω-H-perfluoroalkyl group; R ¹⁷ , R ²⁰ and R ²¹ may be the same or different and each is a straight chain having 1 to 20 carbon atoms. Represents a chain or branched aliphatic hydrocarbon group or an alicyclic or aromatic hydrocarbon group having 5 to 10 carbon atoms; R ¹⁸ represents a hydrogen atom, a linear or branched aliphatic group having 1 to 20 carbon atoms hydrocarbon group, alicyclic or aromatic hydrocarbon group having 5 to 10 carbon atoms, a perfluoroalkyl group or the formula 1 to 20 carbon _{atoms: H (CF 2) g1 -} (g 1 is an integer from 1 to 20 Indicates)
Represents an ω-H-perfluoroalkyl group represented by: R
¹⁹ represents a divalent hydrocarbon group having 2 to 6 carbon atoms; X ² and Y ² represent a single bond, —CO— or a divalent hydrocarbon group having 1 to 6 carbon atoms; i ₁ represents 2 to 16 are shown, j ₁ and k ₁ are ₁ to 16 respectively, and h ₁ is 1 to 20.
0 represents the number, w ₁ represents the number 0 to 20, v ₁ represents the number 0
Indicates the number of 200]

In the structural units represented by the general formulas (11) to (15), as the perfluoroalkyl group represented by Rf and Rf ′, either straight chain or branched chain can be used. , CF ₃ −, C ₂ F ₅ −, C ₄ F
_{9 -, C 6 F 13 -} , C 8 F 17 -, C 10 F 21 -, H (CF 2)
_{2 -, H (CF 2)} 4 -, H (CF 2) 6 -, H (CF 2) 8
_{-, 2 (C 3 F 7} ) C (CF 3) - and the like. Further, as _{g in} H (CF ₂ ) _g −, it is 6 to 2
An integer of 0 is preferred. Examples of the hydrocarbon group represented by R ¹⁷ , R ²⁰ and R ²¹ include direct groups such as methyl group, ethyl group, propyl group, butyl group, pentyl group, hexyl group, heptyl group, octyl group, nonyl group and decyl group. Chain alkyl group; branched chain alkyl group such as isopropyl group, s-butyl group, t-butyl group, neopentyl group, 1-ethylpropyl group, 2-ethylhexyl group; cyclic alkyl group such as cyclopentyl group, cyclohexyl group; phenylnaphthyl Examples thereof include aromatic hydrocarbon groups such as groups. As the divalent hydrocarbon group represented by R ¹⁹ , a linear or branched alkylene group having 2 to 4 carbon atoms is preferable, and an ethylene group and a propylene group are particularly preferable.

Examples of the fluorine-modified silicone having such a structural unit include those represented by the following general formula (16)

[0125]

[Chemical 20]

[Wherein at least one of Z ² and Z ³ represents a structural unit selected from the general formulas (11) to (14), the remainder represents a single bond, and v ₁ , R ²⁰ and R ²¹ are the same as those defined above. Have the same meaning as] or the following general formula (1
7)

[0127]

[Chemical 21]

[Wherein Z^FourAre represented by general formulas (11) to (1
4) represents a structural unit selected from^{twenty two}Has 1 to 2 carbon atoms
0 straight or branched chain aliphatic hydrocarbon group or carbon number
5-10 cycloaliphatic or aromatic hydrocarbon groups are shown,
p₁Indicates a number from 0 to 200, and v ₁, R²⁰And R^{twenty one}Is before
It has the same meaning as above.]
Wear.

The structural units represented by the general formulas (11) to (15) and the groups in each of the fluorine-modified silicones represented by the general formulas (16) and (17) are used as a group for preventing makeup from falling off and usability. In consideration of the above, the following are preferable. Rf and Rf ′ are linear or branched perfluoroalkyl groups having 6 to 20 carbon atoms or the following formulas: H
_{(CF 2) q1 - (q} 1 is an integer of 6-20) preferably omega-H- perfluoroalkyl group represented by.
R ¹⁷ , R ²⁰ and R ²¹ may be the same or different and are preferably linear or branched aliphatic hydrocarbon groups having 1 to 4 carbon atoms. R ¹⁸ is a hydrogen atom, having 6 to 2 carbon atoms
A perfluoroalkyl group of 0 or the following formula; H (CF ₂ ) _q1
Ω-H- represented by- (q ₁ represents an integer of 6 to 20)
Perfluoroalkyl groups are preferred. R ¹⁹ is preferably a divalent hydrocarbon group having 2 to 4 carbon atoms. X ² and Y
² is preferably a single bond, —CO— or a divalent hydrocarbon group having 1 to 4 carbon atoms, i ₁ is preferably 2 to 10, particularly preferably 2 to 5, and j ₁ and k ₁ are each 2 -10, especially 1
Is preferably ₁ to 100, particularly 1 to 10
Is preferred, w ₁ is preferably 0-20, particularly preferably 0-5, and v ₁ is preferably 0-100, especially 0-10. The arrangement of the structural units of the fluorine-modified silicone represented by the general formula (17) may be alternating, block or random.

Further, as a preferable example of the fluorine-modified silicone, the degree of polymerization of 2 to 200 described in JP-A-5-247214 having the structural units represented by the general formulas (12) and (15) is described. Of fluorine-modified silicone,
Japanese Unexamined Patent Application Publication No. 6- having a structural unit represented by general formula (13)
Fluoride-modified silicone having a degree of polymerization of 2 to 200 described in Japanese Patent No. 184312, and a commercial product FSL manufactured by Asahi Glass Co., Ltd.
-300, X-22-819, X- manufactured by Shin-Etsu Chemical Co., Ltd.
22-820, X-22-821, X-22-822 and FL-100, FS-1265 manufactured by Toray Dow Corning Silicone Co., Ltd., and the like.

When these fluorinated oil agents are blended, it is preferable to blend them in an amount of 2 to 98% by weight, particularly 5 to 60% by weight, based on the total composition, since this gives a good feeling in use.

The UV protective agent is not particularly limited, and any of UV scattering agents, oil-soluble UV absorbers and water-soluble UV absorbers which are commonly used can be preferably used. Of these, examples of the ultraviolet scattering agent include titanium oxide and fine particle titanium oxide (Japanese Patent Laid-Open No. 57-67).
681), zinc oxide, fine zinc white (Japanese Patent Laid-Open No. 62-
No. 228006), flaky zinc oxide (Japanese Patent Application Laid-Open No. 1-1)
No. 75921), iron oxide, fine particle iron oxide, cerium oxide, zirconium oxide and the like, which may be surface-treated with silicone, metal soap, N-acyl glutamic acid, perfluoroalkyl phosphate ester or the like. Good. The shape, size and form of these are not particularly limited, and they may be used in the form of a sol or the like.

As the oil-soluble ultraviolet absorber, a benzoic acid-based one is para-aminobenzoic acid (hereinafter referred to as PA).
(Abbreviated as BA), glyceryl PABA, ethyldihydroxypropyl PABA, N-ethoxylate PABA ethyl ester, N-dimethyl PABA ethyl ester, N
-Dimethyl PABA butyl ester, N-dimethyl PA
BA amyl ester, octyl dimethyl PABA, etc .;
As anthranilic acid type, homomenthyl-N
-Acetylanthranilate and the like; as salicylic acid-based ones, amyl salicylate, menthyl salicylate,
Homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate and the like; cinnamic acid-based octyl cinnamate, ethyl-4-isopropyl cinnamate, Ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-
Methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate, 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α -Cyano-β-phenyl cinnamate, glyceryl mono-2-ethylhexanoyl diparamethoxy cinnamate and the like; benzophenone-based compounds such as 2,4-dihydroxybenzophenone,
2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Others: 3- (4'-methylbenzylidene) -dl-camphor, 3-benzylidene-dl-camphor, urocanic acid ethyl ester, 2
-Phenyl-5-methylbenzoxazole, 2,2'-
Hydroxy-5-methylphenylbenzotriazole,
2- (2'-hydroxy-5-t-octylphenyl)
Benzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene)
-3-pentan-2-one, a benzenebis-1,3-diketone derivative described in JP-A-2-212579,
Examples thereof include benzoylpinacolone derivatives described in JP-A-3-220153.

Examples of the water-soluble ultraviolet absorber include diethanolamine p-methoxycinnamate, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, tetrahydroxybenzophenone, methylherperidine, and 3-hydroxy-4-methoxycinnamate. Examples thereof include sodium acidate, sodium ferulate, urocanic acid, and the like, and extracts of animals and plants such as yarrow, aloe, biloba, burdock, and salvia which have an ultraviolet absorbing effect.

Among these UV protectors, zinc oxide, titanium oxide, fine titanium oxide, fine zinc oxide, flaky zinc oxide, fine iron oxide, octyldimethyl PAB are particularly preferable.
A, 2-ethylhexyl-p-methoxycinnamate,
4-methoxy-4'-t-butyldibenzoylmethane,
1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione is preferred.

When these UV protection agents are blended, 0.1-40% by weight, especially 0.1-30% by weight of the total composition is used.
%, More preferably 1 to 20%.

Examples of the powder include extenders such as mica, talc, sericite, kaolin, nylon powder and polymethylsilsesquioxane; inorganic pigments such as pearls;
Organic pigments such as Red No. 202, Red No. 226, Yellow No. 4, aluminum lake, etc. may be mentioned. In addition, these powders are subjected to surface treatment such as silicone treatment, metal soap treatment, amino acid treatment, fatty acid treatment, alkyl phosphate treatment, N-acyl glutamic acid treatment, perfluoroalkyl phosphate treatment, and other fluorine treatment. It may be

When these powders are blended, 0.001 to 50% by weight, particularly 0.005 to 30% by weight, is preferably blended in the entire composition.

Examples of the oil gelling agent include dextrin fatty acid esters such as dextrin palmitate and dextrin stearate. When blending these oil gelling agents, 0.001-20
It is preferable to add the composition in an amount of 0.01% by weight, particularly 0.01 to 5% by weight.

The softener is not particularly limited, and examples thereof include α-hydroxy-isobutyric acid, α-hydroxy-isocaproic acid, α-hydroxy-n-caproic acid, α-hydroxy-isocaprylic acid, α- Hydroxy-n-caprylic acid, α-hydroxy-n-capric acid,
In addition to α-hydroxy acids such as lactic acid, α-hydroxystearic acid, citric acid and glycolic acid, ε-aminocaproic acid, urea and amines such as 2-hydroxyguanidine-2- (2-hydroxyethoxy) ethylguanidine,
JP-A-62-99315 and JP-A-2-17820
Peptides described in Japanese Patent Laid-Open No. 7-29
Trimethylglycine and the like described in Japanese Patent No. 3625 may be mentioned. When blending these softeners, 0.05 to 10% by weight, particularly 0.2 to 5% by weight, based on the total composition.
It is preferable to mix them.

Examples of the pH adjusting agent include metal hydroxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide, triethanolamine, isopropanolamine,
Organic acids such as diisopropanolamine, urea, ε-aminocaproic acid, sodium pyrrolidonecarboxylate, sodium hydrogenphosphate, sodium citrate, citric acid, lactic acid, succinic acid, tartaric acid, betaines such as glycine betaine, lysine betaine, etc. Can be mentioned. The cosmetics of the present invention have a pH of 2 to 11, especially a pH of 3 due to these pH adjusters and the like.
The area of 10 to 10 is preferable.

Further, other components include, for example, inorganic salts such as magnesium sulfate, potassium sulfate, sodium sulfate, magnesium chloride, sodium chloride; preservatives such as paraben, dehydroacetic acid and its salts; edetic acid and its salts, methaline. Sequestering agents for acids and salts thereof; 6-
Hydroxyhexanoic acid, 8-hydroxyundecanoic acid,
Examples thereof include hydroxy acids such as 9-hydroxyundecanoic acid, 10-hydroxyundecanoic acid, ethyl 11-hydroxyundecanoate and salts thereof; pigments, medicinal ingredients, and fragrances.

The cosmetic of the present invention can be manufactured by a conventional method. Further, the cosmetics of the present invention are not limited to general skin cosmetics, but include quasi-drugs, external medicines and the like, and the dosage form can be arbitrarily selected according to the purpose. And can be in the form of cream, ointment, emulsion, lotion, solution, gel, pack, powder, stick or the like.

The cosmetics of the present invention can be used in various forms such as water / oil type emulsified cosmetics, oil / water type emulsified cosmetics, creams, lotions, lotions, oily cosmetics, packs, lipsticks,
It can be used as a cosmetic such as a foundation, a skin cleanser, a hair tonic, a hair styling agent, a hair nourishing agent, and a hair restorer.

[0145]

EFFECT OF THE INVENTION The cosmetic of the present invention synergistically has a moisturizing effect and a preventive / improvement effect on rough skin by using the phosphate triester of the component (A) and the skin active ingredient of the component (B) in combination. , Prevention of skin elasticity, loss of elasticity, dull complexion, etc.
Improvement effect, excess sebum, prevention / improvement effect of conspicuous pores and acne caused by bacteria and abnormal keratinization, prevention / improvement effect of wrinkle formation and prevention / improvement effect of spots / freckles are further enhanced, and feeling of use and It has excellent stability.

[0146]

EXAMPLES The present invention will be described in detail below with reference to examples, but the present invention is not limited thereto. still,
Unless otherwise specified,% in the examples is on a weight basis, and the compounding amount of the plant extract is shown as a value converted into a dry solid content.

Example 1 Cosmetics having the compositions shown in Tables 1 to 6 were produced by a conventional method.
About the obtained cosmetics, the moisturizing effect of the skin when used, the effect of preventing / improving the skin roughness, the effect of preventing / improving the skin's elasticity / reduced elasticity / dull complexion, excessive sebum, bacteria and keratinization Prevention of conspicuous pores and acne caused by abnormalities
The improvement effect, the prevention and improvement effect of wrinkle formation, the prevention and improvement effect of spots and freckles, and the feeling of use were evaluated. The results are shown in Table 1
It shows in Table 6. In addition, the compounding quantity of the plant extract was shown by the value as a dry solid content.

(Evaluation method) Moisturizing effect on skin, preventive / ameliorating effect on rough skin, and skin firmness
Prevents / improves effects such as loss of elasticity and dullness of complexion, excessive sebum, prominence / improvement effects of conspicuous pores and acne caused by bacteria and abnormal keratinization, prevention / improvement effect of wrinkle formation, prevention of spots / freckles・ Improvement effect and usability: 20 professional panelists
The name used each cosmetic for 2 months, and sensory evaluation was performed based on the following criteria. ⊚: 16 or more out of 20 were judged to be good. ◯: 11 to 15 people out of 20 were judged to be good. Δ: 6 to 10 out of 20 were judged to be good. X: Out of 20 people, 5 or less were judged to be good.

[0149]

[Table 1]

[0150]

[Table 2]

[0151]

[Table 3]

[0152]

[Table 4]

[0153]

[Table 5]

[0154]

[Table 6]

1) In the general formula (2), R ⁴ = C ₁₅ H
₃₁ , R ⁵ = CH ₃ (CH ₂ ) ₁₆ = CH 2) In the general formula (3), R ⁶ = C ₁₆ H ₃₃ , R ⁷ = C
₁₅ H ₃₁ , a = b = d = 0, c = 1 3) In the general formula (4), R ⁸ = C ₁₆ H ₃₃ , R ⁹ = C
₁₃ H ₂₇ , R ¹⁰ = C ₃ H ₆ , R ¹¹ = OCH ₃ 4) Hamamelis Liquid (manufactured by Ichimaru Falcos) 5) Falco Rex Buttonpi E (manufactured by Ichimaru Falcos) 6) Asunaro extract (Ichimaru Falcos) 7) Chamomile extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) 8) Green tea liquid (manufactured by Ichimaru Falcos Co., Ltd.) 9) Acidic heteropoly derived from callus of tuberose manufactured according to Example 1 of JP-A-64-10997. Sugar 10) Horse chestnut extract BG (Maruzen Pharmaceutical Co., Ltd.)

As is clear from the results of Tables 1 to 6, as compared with the conventional cosmetics, all of the cosmetics of the present invention have a moisturizing effect, an effect of preventing and improving rough skin, and a firmness and elasticity of the skin. Prevents / improves effects such as fading and dullness of skin, excessive sebum, prevents / improves effects such as conspicuous pores and acne caused by bacteria and abnormal keratinization, prevents / improves wrinkle formation, and prevents / improves spots / freckles The effect was synergistically enhanced, and good results were obtained in terms of feeling in use.

Example 2 An emulsion having the following composition was produced by a conventional method. The obtained milky lotion has a moisturizing effect, a preventive / ameliorating effect on rough skin, a preventive / improving effect on skin's astringency / reduced elasticity / dullness of complexion, excess sebum,
Preventive / ameliorating effects of conspicuous pores and acne caused by bacteria and abnormal keratinization, preventing / improving effect of wrinkle formation and preventing / improving effect of spots / freckles are synergistically enhanced, and also have good feeling in use. The results are shown.

[0158]

[Table 7] (Components) (% by weight) Tris (butoxyethyl) phosphate 5.0 Cetanol 1.0 Squalane 2.0 Ceramide-like structural substance ²⁾ 3.0 Hamamelis extract (Hamamelis Liquid: manufactured by Ichimaru Falcos) 0.5 Acrylic acid-based polymer (Pemlan TR-2: manufactured by BF Gutrich) 0.1 Acrylic acid-based polymer (Carbopol 981: manufactured by BF Gutrich) 0.1 Xanthan gum 0.1 Sodium hyaluronate 0.1 Arbutin 2.0 Rosemary extract (phyterene EG-009 (BG): manufactured by Ichimaru Falcos) 0.5 Polyoxyethylene (40) hydrogenated castor oil 1.0 Acid heteropolysaccharide ⁹⁾ 0 .1 ethanol 5.0 glycerin 2.0 nicotinic acid-dl-α-tocopherol 2.0 estradiol 0.5 succinic acid 0.1 L -Arginine 0.2 Perfume 0.1 Purified water Balance

Example 3 A cream having the following composition was produced by a conventional method. The cream thus obtained has a moisturizing effect, a preventive / ameliorating effect on rough skin, a preventive / ameliorating effect on skin's astringency / reduced elasticity / dull complexion, excessive sebum, conspicuous pores and acne caused by bacteria and abnormal keratinization. The preventive and ameliorating effect of erythrocyte, the preventive and ameliorating effect of wrinkle formation, and the preventive and ameliorating effect of spots and freckles were synergistically enhanced, and the usability was also excellent.

[0160]

Table 8 (Components) (wt%) Tris (butoxyethoxyethyl) phosphate 5.0 Stearic acid 0.6 Cetanol 0.4 Cholesterol 1.0 Squalane 4.0 Ceramide-like structural substance ³⁾ 1.0 Asunaro extraction (Asunaro extract: manufactured by Ichimaru Falcos Co., Ltd.) 0.5 Acrylic acid polymer (Pemlan TR-1: BF Goodrich) 0.2 Acrylic acid polymer (Carbopol 980: BF Good) Rich Co., Ltd.) 0.2 Xanthan gum 0.1 Sodium hyaluronate 0.1 L-Ascorbic acid phosphate magnesium 2.0 Polyoxyethylene (60) hydrogenated castor oil 1.0 Acid heteropolysaccharide ⁹⁾ 0.1 Acetic acid -Dl-α-tocopherol 2.0 zinc sulfocarbonate 0.5 salicylic acid 0.1 ethanol 5.0 glycerin .0 L-Arginine 0.4 Perfume 0.1 Purified water balance

Example 4 A pack agent having the following composition was produced by a conventional method. The obtained packs have a moisturizing effect, prevent / improve skin roughness, prevent / improve skin elasticity / reducing elasticity / dull complexion, excessive sebum, conspicuous pores and acne caused by bacteria and abnormal keratinization. And the like, the effect of preventing and improving wrinkle formation, and the effect of preventing and improving wrinkles and freckles were synergistically enhanced, and also in terms of usability, good results were shown.

[0162]

[Table 9] (Components) (wt%) Tris (butoxyethoxyethoxyethyl) phosphate 5.0 Dipropylene glycol 3.0 Ceramide ¹⁾ 1.0 Polyethylene glycol 3.0 1,3-Butylene glycol 1.0 Acrylic Acid polymer (Sepigeru 305; manufactured by Sepic) 3.0 Polyvinyl alcohol 12.0 Lactic acid 0.5 Aloe extract (Aloe extract: Maruzen Pharmaceutical Co., Ltd.) 0.1 Beef placenta extract (Biofalco CP-12: Ichimaru) Falcos) 1.0 Altea extract (Falco Rex Altea: Ichimaru Falcos) 0.2 Polyoxyethylene (40) hydrogenated castor oil 1.0 Acid heteropolysaccharide ⁹⁾ 0.1 Sodium citrate 1.0 Glycerin 0.5 Hypericum perforatum extract (Hypericum perforatum extract: Maruzen Pharmaceutical Co., Ltd.) 0.5 Royal jelly 0.5 Salicy Acid 0.1 L-arginine 0.2 Ethanol 5.0 Perfume 0.1 Purified water balance

Example 5 An essence having the following composition was produced by a conventional method. The essence obtained is a moisturizing effect, prevention / improvement of rough skin, prevention / improvement of skin elasticity / reduced elasticity / dullness of complexion, excessive sebum, conspicuous pores and acne caused by bacteria and abnormal keratinization. The preventive and ameliorating effect of erythrocyte, the preventive and ameliorating effect of wrinkle formation, and the preventive and ameliorating effect of spots and freckles were synergistically enhanced, and the usability was also excellent.

[0164]

(Table 10) (Components) (wt%) Tris (ethoxyethoxyethyl) phosphate 10.0 Horsetail extract (horsetail extract BG: manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.5 Acrylic acid polymer (Pemlane TR-2: B) F. Gutrich Co., Ltd.) 0.2 Acrylic acid polymer (Carbopol 981: B. F. Gutrich Co., Ltd.) 0.2 Xanthan gum 0.1 Sodium hyaluronate 0.1 Arbutin 2.0 Citric acid 0. 2 Sodium citrate 1.0 Acidic heteropolysaccharide ⁹⁾ 0.1 Ginkgo biloba extract (Ginkgo biloba extract BG: Maruzen Pharmaceutical Co., Ltd.) 0.5 10-Hydroxyundecanoic acid 0.5 Ethanol 5.0 1,3- Butylene glycol 2.0 L-arginine 0.4 Perfume 0.1 Purified water balance

Example 6 A lotion having the following composition was produced by a conventional method. The lotion obtained is a moisturizing effect, a preventive / ameliorating effect on rough skin, a preventive / ameliorating effect on the skin's elasticity, loss of elasticity, dull complexion, etc., excessive sebum, conspicuous pores and acne caused by bacteria and abnormal keratinization. The preventive and ameliorating effect of erythrocyte, the preventive and ameliorating effect of wrinkle formation, and the preventive and ameliorating effect of spots and freckles were synergistically enhanced, and the usability was also excellent.

[0166]

[Table 11] (Components) (wt%) Tris (ethoxyethoxyethoxyethyl) phosphate 10.0 Hamamelis extract ⁴⁾ 0.5 Sodium hyaluronate 0.1 Beef placenta extract (Biofalco CP-12: Ichimaru Falcos) 1.0) Altea extract (Falco Rex Altea: manufactured by Ichimaru Falcos) 0.2 Polyoxyethylene (60) hydrogenated castor oil 1.0 Acid heteropolysaccharide ⁹⁾ 0.1 Sodium citrate 1.0 Ethanol 5 .0 glycerin 0.5 assembly extract (assembly extract liquid: manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.5 12-hydroxystearic acid 0.5 isopropylmethylphenol 0.1 L-arginine 0.2 potassium hydroxide 0.2 fragrance 0 1 Purified water balance

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ identification code FI A61K 7/00 A61K 7/00 KU W XY (72) Inventor Tomohiko Sano 2-1-3 Fumika, Sumida-ku, Tokyo Kao (56) References JP-A-8-183723 (JP, A) JP-A-8-231565 (JP, A) JP-A-9-67224 (JP, A) JP-A-8-310935 (JP , A) JP-A-9-165313 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (14)

(57) [Claims] 1. The following components (A) and (B): (A) General formula (1) [In the formula, R ¹ , R ² and R ³ are the same or different and represent a linear or branched alkyl group having 1 to 4 carbon atoms, and X, Y and Z are the same or different and have 2 or 3 carbon atoms. And a linear or branched alkylene group, wherein l, m and n are the same or different and each represents a number of 1 to 10. ] The phosphoric acid triester represented by these, and (B) skin active ingredient are contained, Cosmetics characterized by the above-mentioned. 2. The phosphoric acid triester of the component (A) has the general formula (1) in which R ¹ , R ² and R ³ are each an alkyl group having 2 to 4 carbon atoms, and X, Y and Z are The cosmetic according to claim 1, wherein the cosmetic is an ethylene group and l, m and n are each a number of 1 to 4. 3. The component (B) comprises ceramides, ceramide-like structural substances, amino acids, plant extracts, whitening agents, anti-inflammatory agents, singlet oxygen scavengers, antioxidants, polysaccharides, water-soluble thickeners. 1 selected from the group consisting of agents, alcohols, sterols, blood circulation promoters, sebum secretion inhibitors, antibacterial agents and keratolytic agents
The cosmetics according to claim 1 or 2, which are one kind or two or more kinds. 4. The component (B) is represented by the following general formula (2):
(7) [Chemical formula 2] [In the formula, R ⁴ and R ⁵ are the same or different and have 8 to 8 carbon atoms.
26 straight or branched, saturated or unsaturated hydrocarbon groups are shown] [In the formula, R ⁶ represents a linear or branched saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ⁷ represents 9 to 2 carbon atoms.
5 represents a straight chain or branched chain saturated or unsaturated hydrocarbon group, Y ¹ and Z ¹ represent a hydrogen atom or a hydroxyl group, and a represents 0
Or a number of 1, c is an integer of 0 to 4, b and d
Represents an integer of 0 to 3] [In the formula, R ⁸ and R ⁹ are the same or different and have 1 to 1 carbon atoms.
40 linear or branched, saturated or unsaturated, optionally hydroxylated hydrocarbon groups, wherein R ¹⁰ is 1 carbon atom
~ 6 is a linear or branched alkylene group or a single bond, and R ¹¹ is a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms, or a 2,3-dihydroxypropyloxy group. However, when R ¹⁰ is a single bond, R ¹¹ is a hydrogen atom. ] [Chemical 5] [In the formula, R ^8a represents an optionally hydroxylated hydrocarbon group having 4 to 40 carbon atoms, R ^10a represents a linear or branched alkylene group having 3 to 6 carbon atoms, and R ^11a represents carbon. The straight-chain or branched-chain alkoxy groups of the formulas 1 to 12 are shown. ] [Chemical 6] [In the formula, R ⁸ , R ⁹ , R ^10a and R ^11a have the same meanings as described above. ] [Chemical 7] [Wherein R ⁸ , R ⁹ and R ¹⁰ have the same meanings as described above,
R ^11b represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms, or a 2,3-epoxypropyloxy group. However, when R ¹⁰ is a single bond, R ^11b is a hydrogen atom. ] The cosmetic according to any one of claims 1 to 3, which is one kind or two or more kinds selected from the group consisting of ceramides and ceramide-like substances represented by: 5. The component (B) is one or more selected from the group consisting of amino acids and salts thereof.
The cosmetic according to any one of 3 above. 6. The component (B) is one or more selected from the group consisting of L-ascorbic acid and its derivative, hydroquinone derivative, kojic acid and its derivative, and placenta extract. The cosmetic according to any one of 1. 7. The cosmetic according to claim 1, wherein the component (B) is one kind or two or more kinds selected from plant extracts. 8. The plant extract is chamomile, tea, cuckoo, clove, clove, licorice, loquat, spruce, ginseng, peony, hawthorn, barley winter, ginger, matsukasa, mulberry bark, magnolia, linden, The cosmetic according to claim 3 or 7, which is one or more selected from the group consisting of extracts of Asenyaku, sardine, aloe, altea, spirea, Dutch pepper, kina, comfrey, rosemary, and funnel. 9. The plant extract according to claim 3 or 7, which is one or more selected from the group consisting of horsetail, gentian, hamamelis, button, kingfisher, cowpea, asunaro, holtsou, hikikoshi and pheasant.
The listed cosmetics. 10. The component (B) is one or more selected from the group consisting of carotene, tocopherol, ascorbic acid, tannic acid, epicatechin gallate and epicarocatechin gallate. Or 1
Cosmetics described in paragraph. 11. The component (B) is tocopherol nicotinate, nicotinic acid amide, tocopherol acetate, senburi extract, Hypericum extract, ginkgo biloba extract, arnica extract, quina extract, hamamelis extract, ginseng essence extract, horse chestnut extract, ginger extract,
1 or 2 selected from the group consisting of salvia extract, hama-bofu extract, salamander extract, rice germ oil, bodige extract, ginger extract and clove extract
The cosmetics according to any one of claims 1 to 3, which are one or more kinds. 12. The makeup according to claim 1, wherein the component (B) is one or more selected from the group consisting of antiandrogens, crude drug extracts, hydroxy fatty acids and astringents. Fee. 13. The component (B) is selected from antibacterial agents 1
Or it is 2 or more types, The cosmetics of any one of Claims 1-3. 14. The component (B) is 1 selected from keratolytic agents.
The cosmetics according to any one of claims 1 to 3, which are one kind or two or more kinds.