JPH09295932A - Slimming agent composition for cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic for slimming having slimming effect and a slimming agent. SOLUTION: This cosmetic for slimming and this slimming agent each contains an extract of Citrus Unshiu Peel and caffeine. A commercial product can each be utilized as the extract of Citrus Unshiu Peel and the caffeine. A formulation of base cosmetic, make up cosmetic, bathing agent, soap, etc., can be adopted as the cosmetic for slimming and a formulation of powder, pill, tablet, external preparation, injection, suppository, etc., can be adopted as the slimming agent.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a slimming cosmetic composition and a slimming agent, which contain chimp extract and caffeine.

[0002]

2. Description of the Related Art Generally, obesity is one of the constituents of the body.
A state in which the proportion of adipose tissue is abnormally increased. That is, when the body takes in more energy than it needs, the excess energy is converted into fat (triglyceride) by the fat cells that make up the adipose tissue, which is abnormally accumulated in the fat cells and leads to obesity. Is done. A commonly used method of promoting the breakdown of these accumulated fats consists of inhibiting phosphodiesterase to prevent or at least limit the degradation of cyclic AMP.

[0003]

As various phosphodiesterase inhibitors which have been conventionally recommended as slimming agents, xanthine derivatives, particularly caffeine, can be mentioned, but in Japan, the compounding amount is restricted and fat is decomposed. The action is not enough. Therefore, as a result of repeated studies to obtain a cosmetic having a strong lipolytic action and an excellent slimming effect, the present inventors have combined thimpy extract and caffeine to obtain a sufficient lipolytic effect for the first time due to their synergistic effect. It was found that the present invention exerted the above-mentioned effects and was excellent in the slimming effect, and completed the present invention based on this finding.

[0004]

[Means for Solving the Problems] That is, the present invention provides a slimming cosmetic composition and a slimming agent characterized by containing a chimp extract and caffeine. Commercially available products can be used as the thimpi extract and caffeine used in the present invention. In addition, commercially available crude drug, chimpi (chin hide), can be extracted and used by a conventional method. For example, thimpi is extracted by adding water, ethanol, 1,3-butylene glycol, propylene glycol or the like alone or as a mixed solvent. The extraction may be performed at room temperature or may be heated, and the solvent may be distilled off after the extraction.

[0005] Chinpi extract and caffeine are 0.001 each in the total amount of the slimming cosmetic composition or slimming agent of the present invention.
˜20% by weight, preferably 0.01 to 10.0% by weight. At a concentration of 0.001% or less, a sufficient effect cannot be obtained, and at a concentration of 20% by weight or more, the effect is not enhanced and it is uneconomical. In the slimming cosmetic composition and slimming agent of the present invention, fats and waxes used in cosmetics and medicines, waxes, etc. within a range that does not impair the effects of thimpy extract and caffeine,
Raw materials such as hydrocarbons, fatty acids, alcohols, esters, and surfactants can be blended. As the slimming cosmetic of the present invention, basic cosmetics such as creams, lotions, milky lotions, and packs, makeup cosmetics such as foundations and lipsticks, bath preparations, and soaps can be used. Further, the slimming agent of the present invention has a dosage form such as powder, pill, tablet, injection, suppository, external preparation, etc., and is manufactured according to a usual formulation technique. The daily dose is 1 mg to 100 mg, preferably 2 mg to 50 mg, which can be administered in 2 to 3 divided doses.

[0006]

EXAMPLES Next, the present invention will be described in detail with reference to Examples, but the present invention is not limited thereto. The parts of the amounts shown in the examples are parts by weight.

Example-1 Lotion Formulation Formulation amount 1. Ethanol 5.0 parts 2. Methyl paraoxybenzoate 0.1 3. Polyoxyethylene (40) hydrogenated castor oil 0.1 4. Perfume proper amount 5. Purified water 10.0 6. Chimpi extract 5.0 7. Caffeine 0.1 8.1,3-Butylene glycol 3.0 9. Glycerin 2.0 10. Xanthan gum 0.02 11. Purified water 69.5 Manufacturing method: Components 1 to 5 and components 6 to 11 are uniformly dissolved, mixed and filtered. The product.

Comparative Example-1 Conventional Lotion A conventional lotion was prepared by replacing the chimp extract and caffeine in Example 1 with purified water.

Example-2 Cream Formulation Amount 1. Liquid paraffin 6.5 parts 2. Vaseline 10.0 3. Stearic acid 4.0 4. Cetyl alcohol 3.0 5. Stearyl alcohol 1.0 6. Polyoxyethylene (25) monostearate 3.0 7. Sorbitan monostearate 2.5 8.1,3-Butylene glycol 5.0 9. Potassium hydroxide 0.1 10. Chinpi extract 2.0 11. Caffeine 0.05 12. Methyl paraoxybenzoate 0.2 13. Purified water 60.5 14. Perfume Suitable amount Production method: Oil phase Components 1 to 7 and water phase components 8 to 13 are heated and dissolved at 70 to 75 ° C, respectively, and then oil phase components 1 to 7 are dissolved in water phase components.
Add 8 to 13 to emulsify, add component 14 on the way of cooling and mix, and cool to 30 ° C to obtain a product.

Example-3 Emulsion formulation Formulation amount 1. Liquid paraffin 8.0 parts 2. Squalane 2.0 3. Stearyl alcohol 2.0 4. Sorbitan monooleate 2.5 5. Glycerin monostearate 2.3 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. Glycerin 6.0 8. Chinpi extract 1.0 9. Caffeine 0.1 10. Methyl paraoxybenzoate 0.2 11. Purified water 76.0 12. Perfume suitable amount Production method: Oil phase components 1 to 6 and water phase components 7 to 11 respectively After heating and melting at 70-75 ℃, the oil phase components 1-6 are converted to the water phase component
Add 7 to 11 to emulsify, add component 12 while cooling and mix, and cool to 30 ° C to obtain a product.

Comparative Example-2 Conventional Emulsion In Example-3, the conventional emulsion was obtained by replacing the thimpy extract and caffeine with purified water.

Example-4 Pack Formulation Amount 1. Polyvinyl alcohol 12.0 parts 2. Ethyl alcohol 5.0 3.1,3-butylene glycol 8.0 4. Methyl paraoxybenzoate 0.2 5. Polyoxyethylene (40) hydrogenated castor oil 0.5 6. Chimpi extract 1.0 7. Caffeine 0.1 8. Citric acid 0.1 9. Sodium citrate 0.3 10. Perfume 0.1 11. Purified water 73.7 Manufacturing method: Dissolve each component uniformly to obtain a product.

Example-5 Foundation Formulation amount 1. Stearic acid 2.4 parts 2. Polyoxyethylene (20) sorbitan monostearate 1.0 3. Polyoxyethylene (20) cetyl ether 2.0 4. Cetyl alcohol 1.0 5. Liquid lanolin 2.0 6. Liquid paraffin 3.0 7. Isopropyl myristate 6.5 8. Butyl paraoxybenzoate 0.1 9. Purified water 58.2 10. Chinpi extract 0.1 11. Caffeine 0.1 12. Sodium carboxymethylcellulose 0.1 13. Bentonite 0.5 14. Propylene glycol 4.0 15. Triethanolamine 1.1 16. Methyl paraoxybenzoate 0.2 17. Titanium oxide 8.0 18. Talc 4.0 19. Coloring pigment 5.0 20. Perfume suitable amount Manufacturing method: Components 10 to 14 and 16 are heated to 70 ° C. and swelled well. Ingredients 9 and 15 are dissolved in this to obtain an aqueous phase. Components 1 to 8 are dissolved by heating and kept at 80 ° C. to form an oil phase. Components 17 to 19 which are well mixed and pulverized through a pulverizer are added to the aqueous phase, and the mixture is stirred with a homomixer and kept at 75 ° C. The oil phase is added to this aqueous phase while stirring and cooled, and component 20 is added at 45 ° C, and the product is cooled with stirring.

Example-6 Bath agent Formulation amount 1. Sodium sulfate 43.0 parts 2. Sodium hydrogencarbonate 50.0 3. Chinpi extract 5.0 4. Caffeine 0.1 5. Yellow No. 202 (1) proper amount 6. perfume proper amount production Method: Mix each component well to make a product.

Example-7 Oily Ointment Formulation Amount 1. Purified lanolin 5.0 parts 2. White beeswax 5.0 3. Chinpi extract 1.0 4. Caffeine 0.1 5. White petrolatum 88.0 Production method: Mix each component well The product.

Example-8 Emulsion Ointment Formulation amount 1. White petrolatum 25.0 2. Stearyl alcohol 22.0 3. Propylene glycol 12.0 4. Sodium lauryl sulfate 1.5 5. Ethyl paraoxybenzoate 0.025 6. Propyl paraoxybenzoate 0.015 7. Chimpi extract 1.0 8. Caffeine 0.1 9. Purified water 37.55 Production method: Oil phase components 1-2 and water phase components 3-9, respectively
After heating and melting at 70-75 ° C, the aqueous phase component 3
Add ~ 9 to emulsify and cool to 30 ℃ to obtain the product.

Example-9 Emulsion Ointment Formulation Amount 1. Cholesterol 3.0 2. Stearyl alcohol 3.0 3. White beeswax 8.0 4. Chinpi extract 1.0 5. Caffeine 0.1 6. White petrolatum 84.0 Manufacturing method: Mixing components After melting by heating to 70-75 ℃,
Cool to 30 ° C to obtain the product.

Example-10 Formulation of water-soluble ointment Blend amount 1. Polyethylene glycol 4000 48.0 2. Polyethylene glycol 400 48.0 3. Chinpi extract 2.0 4. Caffeine 0.2 Production method: Dissolve each component uniformly to obtain a product.

Example-11 Lotion formulation Formulation amount 1. Stearyl alcohol 2.5 2. Liquid paraffin 25.0 3. Sodium lauryl sulfate 1.0 4. Propylene glycol 12.0 5. Methyl paraoxybenzoate 0.025 6. Propyl paraoxybenzoate 0.025 7. Chinpi Extract 5.0 8. Caffeine 0.5 9. Purified water 49.45 Manufacturing method: Oil phase components 1-2 and water phase components 3-9, respectively
After heating and melting at 70-75 ° C, the aqueous phase component 3
Add ~ 9 to emulsify and cool to 30 ℃ to obtain the product.

Example-12 Tablet Formulation Compounding amount 1. Chimpi extract 10.0 parts 2. Caffeine 1.0 3. Corn starch 10.0 4. Purified sucrose 20.0 5. Carboxymethylcellulose calcium 10.0 6. Microcrystalline cellulose 25.0 7. Polyvinylpyrrolidone 5.0 8. Talc 2.0 Production method: Components 1 to 6 were mixed, and then an aqueous solution of component 7 was added as a binder to granulate by a conventional method. Ingredient 8 was added as a lubricant to the mixture, and the mixture was tabletted into 100 mg tablets.

Example-13 Powder formulation Formulation amount 1. Chimpi extract 10 parts 2. Caffeine 1 3. Corn starch 40 4. Microcrystalline cellulose 50 Production method: The above components were mixed and made into a powder by a conventional method.

Example-14 Injectable formulation Formulation amount 1. Chimpi extract 10.0 parts 2. Caffeine 1.0 3. Polyoxyethylene (60) hydrogenated castor oil 37.0 4. Sesame oil 2.0 5. Sodium chloride 9.0 6. Propylene glycol 40.0 7. Phosphate buffer solution (0.1M, pH 6.0) 100.0 8. Distilled water 792.0 Manufacturing method: Mix components 1 to 4 and half amount of component 6 at about 80 ° C.
The mixture was heated and dissolved in, and distilled water in which component 7 and component 5 and component 6 were previously dissolved was heated to about 80 ° C. and added to give an aqueous solution of 1000 ml in total. This aqueous solution was dispensed into a 1 ml ampoule, melted and sealed, and then heat sterilized.

[0023]

The slimming cosmetic composition and slimming agent of the present invention have excellent lipolytic activity and slimming effect. Next, the effects of the slimming cosmetic composition and slimming agent of the present invention will be described in more detail with reference to experimental examples. In addition, the thimpi extract used in the following experimental examples was prepared by adding 10 times amount of 50% (V / V) ethanol aqueous solution to thimpi and extracting at room temperature for 1 week, and then freeze-drying the filtered filtrate. I was there.

Experimental Example 1 Lipolytic activity test using rat epididymal adipocytes Epididymal adipose tissue was extracted from male Wistar rats, and the adipocytes were collected by subjecting it to collagenase treatment. The reaction was initiated by adding an ethanol extract of thimpi and caffeine to the obtained adipocytes (2 × 10 ⁴ ). After 1 hour, the reaction was stopped, and the fatty acid contained in the reaction solution was measured using a fatty acid quantification kit. as a result,
Chympi ethanol extract 0.5 mg / ml and caffeine 0.
1 mg / ml did not show lipolytic activity by itself, but showed a remarkable lipolytic activity by combining both (Table 1). Also, hot water extract of chimpi, 1,3-
When the butylene glycol extract and the propylene glycol extract were tested in the same manner, the same lipolytic activity was exhibited. Below margin

[0025]

[Table 1] Table 1 Lipolytic activity ──────────────────────────────────── Sample (sample concentration) Fatty acid content (mEq / l) Lipolysis promotion rate (%) ───────────────────────────────────── Control 0.067 Chinpi extract (0.1 mg / ml) 0.071 6 Chinpi extract (0.3 mg / ml) 0.073 9 Chinpi extract (0.5 mg / ml) 0.10 51 Caffeine (0.05 mg / ml) 0.071 6 Caffeine (0.1 mg / ml) 0.074 11 Chimp extract (0.1mg / ml) + caffeine (0.05mg / ml) 0.098 46 Chimp extract (0.1mg / ml) + caffeine (0.1mg / ml) 0.28 320 Chimp extract (0.3 mg / ml) + caffeine (0.05mg / ml) 0.14 110 chimp extract (0.3mg / ml) + caffeine (0.1mg / ml) 0.87 1200 chimp extract (0.5mg / ml) + caffeine (0.05mg / ml) 0.32 380 Chinpi extract (0.5mg / ml) + caffeine (0.1mg / ml) 1.28 1800 ─────────────────── ───────────────── following margin

Experimental Example-2 Usage Test Using the lotion of Example-1, the emulsion of Example-3, the conventional lotion of Comparative Example-1 and the conventional emulsion of Comparative Example-2,
Each of 30 women (30 to 45 years old) was subjected to a usage test for one month. After use, the slimming effect was determined by a questionnaire survey on the firmness, tension and elasticity of the skin. As a result, the cosmetics characterized by containing the Chinpi extract and caffeine showed excellent slimming effects (Table 2, Table 3, Table 4, Table 5).

[0027]

[Table 2] Table 2 Slimming effect of skin lotion of the present invention (number of questionnaire results) ─────────────────────────────── ── Lotion of the present invention (Example-1) Evaluation ─────────────────────── Very good Good Normal ──────── ──────────────────────── Tightening of the skin 20 7 3 Tension of the skin 19 8 3 Elasticity of the skin 18 8 4 ────── ────────────────────────── Margins below

[0028]

[Table 3] Table 3 Slimming effect of conventional lotion (number of questionnaire results) ──────────────────────────────── ── Conventional lotion (Comparative example-1) ──────────────────────── Very good Good Normal ───────── ──────────────────────── Tightening of the skin 3 7 20 Tension of the skin 2 7 21 Elasticity of the skin 4 9 17 ────── ────────────────────────────

[0029]

[Table 4] Table 4 Slimming effect of the emulsion of the present invention (number of questionnaire results) ──────────────────────────────── -Emulsion of the present invention (Example-3) Evaluation ─────────────────────── Very good Good Normal ─────────── ────────────────────── Tightening of the skin 20 8 2 Tension of the skin 16 10 4 Elasticity of the skin 19 8 3 ───────── ──────────────────────── Margins below

[0030]

[Table 5] Table 5 Slimming effect of conventional emulsion (number of questionnaire results) ───────────────────────────────── Conventional emulsion (Comparative example-2) Evaluation ──────────────────────── Very good Good Normal ──────────── ───────────────────── Tightening of the skin 5 4 21 Tension of the skin 4 7 19 Elasticity of the skin 2 8 20 ───────── ─────────────────────── When similar usage tests were conducted for other examples,
The same effect was obtained. As shown above, by combining the extract of coffea and caffeine, it exhibits excellent lipolytic activity not shown alone, and the cosmetics and slimming agents containing the extract of caffeine and caffeine of the present invention are It showed an excellent slimming effect.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display location A61K 35/78 ADA A61K 35/78 ADAK

Claims (2)

[Claims] 1. A slimming cosmetic composition comprising a chinpi extract and caffeine. 2. A slimming agent comprising a chimpi extract and caffeine.