JP2005232058A - Skin care preparation for external use and fiber each having lipid decomposition promoting effect - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation for external use and a fiber each containing a xanthine derivative and increased in its percutaneous absorbability. <P>SOLUTION: The skin care preparation and the fiber are obtained each by compounding the xanthine derivative and one or more component selected from the group consisting of isostearyl alcohol, diisopropyl sebacate and an alkylene polyglycol dineopentanoate. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to an external preparation for skin and a fiber for promoting lipolysis.

In order to reduce excess fat on the face and body and maintain a firm body, it is known to use external preparations for skin such as gels and creams that promote metabolism in the body in addition to various exercises and dietary restrictions. It is a well-known fact that such an external preparation for skin contains a xanthine derivative such as caffeine as a substance that promotes lipolysis of fat cells constituting fat and brings about a slimming effect. In addition, attempts have been made to fix caffeine to a fiber so that the fiber has a slimming function (Patent Document 1). However, although xanthine derivatives such as caffeine have a high lipid degradation promoting action, their percutaneous absorption is low, and thus there is a problem that sufficient effects cannot be exhibited. For example, various attempts have been made such as adding a plant extract having an action of promoting lipolysis in addition to a xanthine derivative and other components to enhance the effect of promoting lipolysis (for example, Patent Documents 2 and 3). However, all of these attempts are to further enhance the lipid degradation promoting effect by adding another substance having a lipid degradation promoting action, and could not enhance the percutaneous absorption of the xanthine derivative. Therefore, it has been strongly desired to enhance percutaneous absorption of xanthine derivatives in external preparations or fibers containing xanthine derivatives.
JP 2000-212873 A JP 11-246458 A JP-A-10-101546

  In view of the circumstances as described above, the present invention provides a skin external preparation and a fiber having a higher lipid degradation promoting effect by enhancing transdermal absorption of the xanthine derivative in a skin external preparation or fiber containing a xanthine derivative. It is intended.

  The inventor can percutaneously absorb the xanthine derivative by blending together with the xanthine derivative, one or more oils selected from the group consisting of isostearyl alcohol, diisopropyl sebacate and alkylene polyglycol dineopentanoate. It has been found that it can be remarkably enhanced and the present invention has been completed.

  The present invention provides a skin external preparation containing a xanthine derivative and one or more oils selected from the group consisting of isostearyl alcohol, diisopropyl sebacate, and alkylenepolyglycine dineopentanoate. By blending these oils together with the xanthine derivative, percutaneous absorption of the xanthine derivative can be remarkably enhanced when the skin external preparation is applied to the skin.

  The skin external preparation of the present invention is preferably a skin external preparation for promoting lipid degradation, for example, a slimming skin external preparation.

  Furthermore, the present invention provides a fiber comprising a xanthine derivative and one or more oils selected from the group consisting of isostearyl alcohol, diisopropyl sebacate and dineopentanoic acid alkylene polyglycol. By incorporating these oils into the fiber together with the xanthine derivative, the transdermal absorption of the xanthine derivative through the fiber can be remarkably enhanced.

  In particular, when isostearyl alcohol is blended, the percutaneous absorption of the xanthine derivative is further enhanced. Therefore, the external preparation for skin or fiber of the present invention preferably contains isostearyl alcohol.

  In addition, caffeine is preferably used as the xanthine derivative because of its excellent lipid degradation promoting effect.

  The skin external preparation and fiber of the present invention were applied to the skin because they contain one or more oils selected from the group consisting of isostearyl alcohol, diisopropyl sebacate and tripropylene glycolineopentanoate together with a xanthine derivative. In this case, the transdermal absorption of the higher xanthine derivative can be brought about, and the action of promoting the degradation of lipid by the xanthine derivative can be enhanced to bring about a larger slimming effect.

  Examples of the xanthine derivative used in the present invention include caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxyphylline, or oxtriphyrin, or salts thereof. In the present invention, these xanthine derivatives can be used alone or in combination of two or more. In particular, caffeine is preferably used in the present invention because of its excellent lipid degradation promoting effect. These xanthine derivatives may be naturally derived or synthesized, and commercially available products can be used in the present invention.

  The blending amount of the xanthine derivative in the skin external preparation of the present invention is appropriately determined according to the mode of the skin external preparation and the like, and is not particularly limited, but is preferably 0.0001 mass relative to the mass of the skin external preparation. % Or more, more preferably 0.005 to 5.0 mass%.

  The amount of the xanthine derivative added to the fiber of the present invention is appropriately determined according to the type of fiber and the purpose of use, and is not particularly limited, but is preferably 0.001 to 10 with respect to the mass of the processed fiber. % By mass, more preferably 0.005 to 5% by mass.

  Isostearyl alcohol is an oily component used as a liquid makeup or emulsion fluidity regulator or plasticizer, or as a sebum transfer promoting component in a scalp and hair composition, such as Risonol-18SP, isostearyl alcohol EX, etc. Commercial products can be used in the present invention.

  Diisopropyl sebacate is used in hair cosmetics and creams as an oily component having an emollient or moisturizing effect. For example, commercially available products such as NIKKOL DIS (manufactured by Nikko Chemicals) and mat loop (manufactured by Seiwa Kasei) are used. It can be used in the present invention.

The dineopentanoic acid alkylene polyglycol used in the present invention is a compound represented by the following general formula (1) described in International Publication No. 03/026698 pamphlet:

  Specifically, dineopentanoic acid tripropylene glycol, dineopentanoic acid dipropylene glycol, dineopentanoic acid tetraethrene glycol, dineopentanoic acid troethrene glycol, dineopentanoic acid diethylene glycol and the like can be mentioned. In particular, dineopentanoic acid tripropylene glycol is preferably used in the present invention because it has a refreshed feeling of use, has little skin irritation and is excellent in safety.

  Said oil component can be used in this invention individually by 1 type or in combination of 2 or more types.

  The blending amount of the oil in the skin external preparation of the present invention is appropriately determined depending on the form of the skin external preparation and the like, and is not particularly limited, but is preferably 0.001 to 50 mass with respect to the mass of the skin external preparation. %, More preferably in the range of 0.005 to 20% by mass.

  The amount of the oil added to the fiber of the present invention is appropriately determined according to the type of fiber and the purpose of use, and is not particularly limited, but is preferably 0.001 to 10 with respect to the mass of the processed fiber. % By mass, more preferably 0.005 to 5% by mass.

  In the present specification, the “external preparation for skin” includes cosmetics, pharmaceuticals, quasi drugs and the like. Moreover, the dosage form is also arbitrary such as aqueous solution system, solubilization system, emulsification system, oil liquid system, gel system, paste system, ointment system, aerosol system, water-oil two-layer system, water-oil-powder three-layer, etc. Including dosage forms. Moreover, what was carry | supported by the sheet-like base is also included.

  The external preparation for skin of the present invention contains, in addition to the above-described essential constituents, other optional components that are usually used in external preparations for skin, such as cosmetics and pharmaceuticals, as appropriate, depending on the intended dosage form. Can be produced by conventional methods. For example, the external preparation for skin of the present invention can be prepared by blending the above essential blending components and one or more of the following components.

  Examples of the ultraviolet absorber include paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, Benzoic acid UV absorbers such as N, N-dimethyl PABA butyl ester and N, N-dimethyl PABA methyl ester, anthranilic acid UV absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homo Salicylic acid UV absorbers such as menthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2 , 4-Diisopropylcin Mate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p- Methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, Cinnamic acid UV absorbers such as glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, methyl bis (trimethylsiloxane) silylisopentyl trimethoxycinnamate, 3- (4'-methylbenzylidene) -d, 1-camphor , 3-benzylidene-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5- Methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methyl Phenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, dimorpholinopyrida Dinone etc. are mentioned, Arbitrary 1 type, or 2 or more types can be used.

  Examples of the ultraviolet scattering agent include powders of titanium oxide, fine particle titanium oxide, zinc oxide, fine particle zinc oxide, iron oxide, fine particle iron oxide, cerium oxide, and the like.

  As these ultraviolet scattering agents, needle-like, spindle-like, spherical and granular powders are usually used. A fine particle powder having a particle size of 0.1 μm or less is preferred.

  Silicone treatment such as methyl hydrogen polysiloxane and silane coupling agent; metal soap treatment; UV scattering agent that has been hydrophobized by fluorine treatment such as perfluoroalkyl phosphate diethanolamine salt and perfluoroalkyl silane, dextrin fatty acid ester treatment, etc. Is also preferable.

  Examples of liquid oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern castor oil, castor oil, linseed oil , Safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin and the like.

  Examples of the solid fat include cacao butter, palm oil, horse fat, hydrogenated palm oil, palm oil, beef tallow, sheep fat, hydrogenated beef tallow, palm kernel oil, pork fat, beef bone fat, owl kernel oil, hydrogenated oil, cattle Leg fats, moles, hydrogenated castor oil and the like.

  Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, and reduced lanolin. , Jojoballow, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.

  Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, polyethylene wax, and Fischer-Tropsch wax.

  Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, toluic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the like. Is mentioned.

  Examples of higher alcohols include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol); branched chain alcohols (eg, monostearyl glycerin ether (batyl alcohol) ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, octyldodecanol and the like.

  Synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate Lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, monoisostearate N-alkyl glycol, neopentyl glycol dicaprate, apple Acid diisostearyl, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylo Propane, tetra-2-ethylhexanoate pentaerythritol, glycerol tri-2-ethylhexanoate, glycerol trioctanoate, glycerol triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmi Tate, glyceryl trimyristate, glyceride tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2 -Octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate Le, 2-ethylhexyl succinate, triethyl citrate, polyoxyethylene-polyoxypropylene random polymer methyl ether.

  Examples of the silicone oil include linear polysiloxanes (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexyl). And silicone resins that form a three-dimensional network structure, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.) It is done.

  In addition, for example, moisturizers such as polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol; cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl hydroxypropyl cellulose, methyl cellulose, carboxymethyl cellulose, Quince seed, carrageenan, pectin, mannan, curdlan, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, hydroxy Ethyl guar gum, carboxymethyl guar gum, guar gum, dextran, keratosulfuric acid, b -Cast bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethylchitin, thickeners such as agar, lower alcohols such as ethanol; antioxidants such as butylhydroxytoluene, tocopherol, phytin; benzoic acid, salicylic acid , Sorbic acid, paraoxybenzoic acid alkyl ester, hexachlorophene and other antibacterial agents; acyl sarcosine acids (eg, lauroyl sarcosine sodium), glutathione, citric acid, malic acid, tartaric acid, lactic acid and other organic acids; vitamin A and its derivatives, vitamins B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B such as vitamin B12, vitamin B15 and its derivatives, ascorbic acid, ascorbic acid sulfate (salt) Ascorbic acid phosphate (salt), vitamin C such as ascorbic acid dipalmitate, vitamin E such as α-tocopherol, β-tocopherol, δ-tocopherol, vitamin E acetate, vitamin D, vitamin H, pantothenic acid, pantethine Vitamins such as nicotinamide, benzyl nicotinate, γ-oryzanol, allantoin, glycyrrhizic acid (salt), glycyrrhetinic acid and its derivatives, hinokitiol, bisabolol, eucalptone, thymol, inositol, saikosaponin, carrot saponin, loofah Saponins such as saponins and muclodisaponins, pantothenyl ethyl ether, ethinyl estradiol, tranexamic acid, arbutin, cephalanthin, placenta extract and other various drugs, borage, La, corn, orange, sage, yarrow, mallow, assembly, thyme, spruce, spruce, birch, horsetail, loofah, maronier, saxifrage, arnica, lily, mugwort, peonies, aloe, gardenia, sawara, hawthorn extract Extract, Iris-in extract, Acacia catechu extract, Ginkgo biloba extract, Eustoma biloba extract, Fennel extract, Oolong tea extract, Water lily extract, Ages extract, Enme iso extract, Ogon extract, Oat extract, Odrianthus extract, Licorice extract, Gardenia extract , Tea extracts, sesame extract, tormentilla extract, rose extract, loofah extract, peppermint extract, rosemary extract, royal jelly extract, etc. Dye, sorbitan monolaurate, sorbitan monopalmitate, sorbitan sesquioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxethylene sorbitan monostearate, polyethylene glycol monooleate, polyoxyethylene alkyl ether, polyglycol di Nonionic active agents such as ether, lauroyl diethanolamide, fatty acid isopropanol amide, maltitol hydroxy fatty acid ether, alkylated polysaccharide, alkyl glucoside, sugar ester, cationic properties such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide Surfactant, sodium palmitate, sodium laurate, sodium laurate, laur Anionic surfactants such as potassium sulfate, alkyl sulfate triethanolamine ether, funnel oil, linear dodecylbenzene sulfate, polyoxyethylene hydrogenated castor oil maleic acid, acylmethyltaurine, amphoteric surfactant, neutralizing agent, δ- Examples thereof include antioxidants such as tocopherol and butylhydroxytoluene, and preservatives such as phenoxyethanol and paraben.

  In this specification, “fiber” includes a fiber material, an intermediate product, and a final sewing product.

  The type of fiber material is not particularly limited, but natural fibers such as cotton, wool, silk and hemp, chemical fibers such as rayon and acetate, nylon, polyester, polyurethane, polyethylene, polypropylene, polyvinyl chloride, acrylic, etc. A synthetic fiber is mentioned. These fibers may be either a single type or a mixture of two or more types.

  Examples of the intermediate product include various forms such as a cotton-like product, a tow, a top, a thread, a nonwoven fabric, a woven fabric, and a knitted fabric.

  Examples of the final sewing product include underwear such as pants, shirts, socks, pantyhose, and girdle, clothes such as trousers and skirts, towels, handkerchiefs, masks, and gloves. Especially, it is preferable that they are the sewing final products, such as the underwear which touches skin directly, or the fiber which comprises these.

  Furthermore, the external preparation for skin and fibers of the present invention may contain other optional components having a lipolysis promoting effect and a fat accumulation suppressing effect in addition to the xanthine derivative. Such ingredients include, for example, Lauandula, Anxifolia, Lavender, Anxifolia Pyrenica, Spike Lavender, Lavandin Fennel, Italian Fennel, Rosemary, Mishima Psycho, Manshu Mishima Psycho, Dafrika Psycho, Green Tea, Oolong Tea, etc. Tea extracts, plant extracts such as cacao, hops, perilla, salvia, cora, koffia, β-adrenergic stimulants, α2-adrenergic inhibitors, bipyridine derivatives, and the like.

    EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated concretely, this invention is not limited to the following Example.

Examination of percutaneous absorption Preparations containing each oil were prepared according to the formulations shown in Table 1 (controls, Examples 1 to 3 and Comparative Example 1). In this test, caffeine was used as a xanthine derivative. All compounding amounts are expressed in mass% with respect to the total amount of the formulation:

The percutaneous absorption test was performed by a tape stripping method. Tape stripping is a common technique for measuring drug concentration in the stratum corneum. The test was carried out in the following procedure in three panelists in each group:
(1) The inner side of the forearm of both panels of the paneler is washed with soap. (2) The formulation of the formulation shown in Table 1 (control, Examples 1 to 3, Comparative Example 1) is applied to the inner side of the forearm (20 ml / 20 cm ² )
(3) Leave for 6 hours (4) Wash the inner forearm of both arms with soap (5) Remove the stratum corneum from the inner forearm with tape (manufactured by Nichiban). Repeat)
(6) Extract caffeine from tape with ion-exchanged water (7) Quantify caffeine in the extract by HPLC

The concentration of caffeine in the stratum corneum (μg / cm ² ) was calculated from the amount of caffeine collected from the stratum corneum peeled from the tape, and the average value of the three panelists was obtained. The results are shown in Table 2:

  As is apparent from Table 2, percutaneous absorption of the xanthine derivative can be promoted by blending isostearyl alcohol, diisopropyl sebacate, or tripropylene glycol dineopentanoate together with the xanthine derivative.

  Below, the formulation example of the skin external preparation of this invention is shown as an Example. In addition, all compounding quantities are represented by the mass% with respect to the formulation whole quantity.

Example 4: Lotion ethyl alcohol 5
Glycerin 1
1,3-butylene glycol 5
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.2
Sodium hexametaphosphate 0.03
Trimethylglycine 1
Sodium polyaspartate 0.1
α-tocopherol 2-L-ascorbic acid phosphate diester potassium 0.1
Isostearyl alcohol 1
Caffeine 0.2
DOKUDAMI EXTRACT 0.1
Thiotaurine 0.1
Green tea extract 0.1
Western mint extract 0.1
HEDTA3 sodium 0.1
Carboxyvinyl polymer 0.05
Potassium hydroxide 0.02
Appropriate amount of phenoxyethanol Purified water

Example 5: O / W type emulsion dimethylpolysiloxane 3
Decamethylcyclopentasiloxane 4
Ethanol 15
Glycerin 6
1,3-butylene glycol 5
Polyoxyethylene methyl glucoside 3
Sunflower oil 1
Squalane 2
Isostearyl alcohol 5
Diisopropyl sebacate 0.5
Potassium hydroxide 0.1
Sodium hexametaphosphate 0.05
Hydroxypropyl-β-cyclodextrin 0.1
Caffeine 1
Hypericum perforatum extract 0.5
Dipotassium glycyrrhizinate 0.05
Loquat leaf extract 0.1
Sodium L-glutamate 0.05
Fennel extract 0.1
Yeast extract 0.1
Lavender oil 0.1
Giant extract 0.1
Dimorpholinopyridazinone 0.1
Menthol 1.0
Xanthan gum 0.1
Carboxyvinyl polymer 0.1
Acrylic acid / alkyl methacrylate copolymer (Pemulene TR-1) 0.1
Color material appropriate amount
Paraben Appropriate amount of purified water Residual

Example 6: O / W type emulsion dimethylpolysiloxane 2
Behenyl alcohol 1
Batyl alcohol 0.5
Glycerin 5
1,3-butylene glycol 7
Erythritol 2
Hardened oil 3
Squalane 6
Isostearyl alcohol 5
Dineopentanic acid dipropylene glycol 0.5
Tetra-2-ethylhexanoic acid pentaerythlit 2
Polyoxyethylene glyceryl isostearate 1
Polyoxyethylene glyceryl monostearate 1
Caffeine 0.01
Hawthorn extract 1
Potassium hydroxide appropriate amount Sodium hexametaphosphate 0.05
Phenoxyethanol appropriate amount carboxyvinyl polymer 0.1
Purified water residue

Example 7: O / W type cream liquid paraffin 3
Vaseline 1
Dimethylpolysiloxane 1
Stearyl alcohol 1.8
Behenyl alcohol 1.6
Glycerin 8
Dipropylene glycol 5
Macadamia nut oil 2
Hardened oil 3
Squalane 6
Stearic acid 2
Isostearyl alcohol 10
Dineopentanoic acid diethylene glycol 1
Cholesteryl hydroxystearate 0.5
Cetyl 2-ethylhexanoate 4
Polyoxyethylene hydrogenated castor oil 0.5
Self-emulsifying glyceryl monostearate 3
Potassium hydroxide 0.15
Sodium hexametaphosphate 0.05
Trimethylglycine 2
α-tocopherol 2-L-ascorbic acid phosphate diester potassium 1
Caffeine 0.5
Theophylline 1
Juyaku Extract 0.5
Tocopherol acetate 0.1
Green tea extract 0.1
Paraben appropriate amount edetate trisodium 0.05
4-t-butyl-4′-methoxydibenzoylmethane 0.05
Diparamethoxycinnamic acid mono-2-ethylhexanoate glyceryl 0.05
Colorant Appropriate amount Carboxyvinyl polymer 0.05
Purified water residue

Example 8: Gelglycerin 2
1,3-butylene glycol 5
Dineopentanoic acid tripropylene glycol 1
Potassium hydroxide 0.1
Fish collagen 20
Xanthine 0.1
Fennel extract 1
Edetic acid-3Na 0.05
Carboxyvinyl polymer 0.25
P-Hydroxybenzoate appropriate amount purified water remaining

Example 9: Impregnation mask
Glycerin 1
1,3-butylene glycol 8
Xylit 2
Polyethylene glycol 1500 2
Diisopropyl sebacate 1
Rosemary oil 0.01
Sage oil 0.1
Caffeine 5
Lavender 0.5
Citric acid 0.02
Sodium citrate 0.08
Sodium hexametaphosphate 0.01
Hydroxypropyl-β-cyclodextrin 0.1
Aloe extract 0.1
Birch extract 0.1
Lavender oil 0.01
Xanthan gum 0.05
Carboxyvinyl polymer 0.15
P-Hydroxybenzoate appropriate amount purified water remaining

Example 10: W / O type cream glycerin 1.0
Xylitol 1.0
Purified water Residual cyclomethicone 20.0
Isostearyl alcohol 10
Dineopentanoic acid tripropylene glycol 1
Diisopropyl sebacate 1
Polyvinyl alcohol 2.0
Trioctanoin 3.0
Cetanol 0.1
Dimethicone copolyol 2.5
Quaternium-18 hectorite 1.5
Caffeine 1
Paraben Appropriate amount of colorant Appropriate amount of perfume Appropriate amount

All of these external preparations for skin of Examples 4 to 10 had an excellent lipid metabolism promoting action.

Claims (6)

A skin external preparation containing a xanthine derivative and one or more oils selected from the group consisting of isostearyl alcohol, diisopropyl sebacate and alkylene polyglycol dineopentanoate. The topical skin preparation according to claim 1, comprising isostearyl alcohol. The external preparation for skin according to claim 1 or 2, wherein the xanthine derivative is caffeine. The skin external preparation according to any one of claims 1 to 3, which is a skin external preparation for promoting lipid degradation. The skin external preparation according to claim 4, which is a slimming skin external preparation. A fiber comprising a xanthine derivative and one or more oils selected from the group consisting of isostearyl alcohol, diisopropyl sebacate and alkylene polyglycol dineopentanoate.