JPH0736661Y2 - catheter - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial field of application) The present invention relates to a catheter for percutaneous implantation. More specifically, the present invention relates to a catheter that allows continuous or intermittent injection of a drug solution by transplanting it into the skin of a patient and supplementing it with a drug solution such as a nutritional supplement or an antibiotic as needed.

(Prior Art) As a catheter of this type, a catheter as shown in FIG. 2 is conventionally known. FIG. 2 is a cross-sectional view of a type of percutaneous implantation.

The catheter shown in FIG. 2 is composed of a drug introduction portion 9 including a puncture portion 4 and a connecting tube 3, a flange portion 2 and a tube 1 embedded in a tissue or a blood vessel. The puncture portion 4 is integrally provided with a rubber button 5. The flange portion 2 is provided so that the catheter can be fixed to the skin, and is therefore made of a hard material that hardly affects the living body, such as stainless steel, titanium, ceramics such as hydroxyapatite, or tetrafluoroethylene. . A soft material such as silicone rubber may be used for a part of the flange. For tube 1,
Generally, silicone rubber is used, and as the rubber button 5, silicone rubber or natural rubber is used. The rubber button has a function of introducing a drug or the like into the catheter by puncturing an injection needle.

(Problems to be Solved by the Invention) In such a conventional catheter, silicone rubber is used as a material for the tube 1 to be inserted into a blood vessel. Silicone rubber is a material that is not deteriorated even when placed in a living body and has excellent tissue compatibility, but is not a material having good antithrombogenicity. This catheter is used by being implanted percutaneously, and its use is often long-term. In addition, since it is often placed in a vein where the blood flow rate is slow and thrombus is likely to occur, in order to use this catheter safely for a long period of time, the antithrombogenicity of the tube portion is required. In recent years, for the purpose of intensively and continuously administering an anticancer agent to an organ having an unresectable progressive malignant tumor, the catheter has been placed in a blood vessel flowing into this organ for treatment. In this case, when a blood vessel is blocked by a thrombus, blood is not supplied to an organ downstream thereof, which poses a great risk.

Also, backflow of blood into the lumen of the tube is an unavoidable problem during use of the catheter. In general administration of nutritional supplements, it is necessary to pass nutrients through the tube at least once a day, which also has the effect of cleaning the inside of the tube to prevent blockage, but depending on the drug, administration once a week Therefore, the frequency of cleaning the inside of the tube may decrease. Usually, when the administration of a drug or the like is completed, the lumen of the tube is filled with a solution prepared by adding an anticoagulant such as heparin to physiological saline from the flange portion to prevent the lumen of the tube from being clogged. However, even if this treatment is performed, it cannot be said to be perfect, and due to the momentum of the blood flow, a small amount of blood flows backward from the opening at the tip of the tube and enters. Therefore, even if the blood vessel is not occluded, there is a problem that the lumen of the tube is clogged with blood components and the drug or the like cannot be administered, and the original function of the catheter is often impaired.

(Means for Solving Problems) The present invention solves such a problem, and the gist thereof is a catheter including a drug introduction part, an intracorporeal indwelling tube, and an intravascular indwelling tube. , At least the intravascular indwelling tube is made of a polyurethane-based material and the tissue indwelling tube is made of silicone rubber,
Preferably, it relates to a catheter in which the indwelling tube for tissue and the indwelling tube for blood vessel are connected by a connector.

An embodiment of the present invention will be described below with reference to the drawings.

FIG. 1 is a sectional view showing an embodiment of a percutaneous implant type catheter of the present invention.

Here, the percutaneous transplantation means that a catheter puncture portion is punctured by an injection needle outside the body in order to introduce a drug or the like into the body, and a part of the catheter is guided through the skin and fixed outside the body.

In the above-mentioned embodiment, it is preferable that the tube 1 which has been conventionally used integrally is divided into an intravascular indwelling tube 6 and a tissue indwelling tube 7, and these are connected by a connector 8. That is, since the anti-thrombotic property is strongly required for the intravascular indwelling tube and the tissue compatibility is strongly required for the tissue indwelling tube as described above, these are divided and are suitable for each. This is because the material and the shape are suitable for the purpose of the present invention. That is, the intravascular indwelling tube 6 is made of a polyurethane material. Examples of polyurethane materials include polyurethane, polyurethane-based copolymers,
Polymer blends containing polyurethane are used, and segmented polyurethane is particularly preferably used.

Further, since the tissue indwelling tube 7 is strongly required to have tissue compatibility, silicone rubber is used. The connector 8 connecting the two tubes is formed of a metal such as stainless steel, titanium, or the like, or a plastic such as polycarbonate, tetrafluoroethylene, or the like, which is less likely to deteriorate. As the connector, it is preferable that the outer surface of the connector is formed with a ridge or a groove along the outer peripheral direction in order to prevent the respective tubes from coming off.

Thus, according to the catheter of the present invention, the subcutaneously implanted part in the living body is composed of the best material for intravascular use and intra-tissue use, so that it can be used for a long period of time with peace of mind. Can be used.

Further, when the connector 8, the flange 2 and the like are made of a metal material, it is preferable to use titanium or a titanium alloy which is a non-magnetic material so as not to adversely affect MRI diagnosis and the like.

Furthermore, when the intravascular indwelling tube 6 of the catheter as in the present invention is inserted into a blood vessel, it cannot be generally inserted using a guide wire, a stylet, or the like, and insertion is often difficult. Therefore, as shown in FIG. 1, by inserting the distal end of the intravascular indwelling tube 6 so as to be inclined with respect to the axial direction of the tube, insertion becomes easy. The inclination is preferably formed so that the tip is sharp. In the embodiment shown in FIG. 1, the drug introducing portion 9 is formed of a puncturing portion 4 having a rubber button 5 and a connecting tube 3 connected to the puncturing portion. The puncture part is formed from a rubber button such as silicone rubber or natural rubber and a plastic part that holds the structure, and has the function of introducing drugs etc. into the catheter by puncturing the injection needle, and a structure that can withstand repeated punctures. It is preferable to have The connecting tube 3 is formed of a soft tube such as polyvinyl chloride, and is connected to the tissue indwelling tube via a flange.

Further, the intravascular indwelling tube 6 and the tissue indwelling tube may be integrally formed without using a connector. In that case, it is preferable that the outer circumference of the portion corresponding to the indwelling tissue tube is covered with silicone rubber.

The rubber button provided on the puncture portion is formed of the same structure and material as described in the conventional example of FIG. Further, the structure of the flange portion 2 may be the same as that of the conventional example already described, and for example, it is composed of a portion for connecting the tube with the rubber button portion 5 having a wide puncture portion,
It is shaped so that it can be stably fixed to the skin.

(Example) (1) Comparative Example A subcutaneous implantable catheter in which a tube 1 inserted into a blood vessel as shown in FIG. 2 is made of silicone rubber is embedded so that the tube enters the upper mesenteric vein of a goat. It is. Rubber button 5 twice a day for one week after surgery and once a day after that
About 50 cc of heparinized physiological saline was injected. 15 days after the operation, the inside of the tube was blocked and it became impossible to inject intravenously.

(2) Example A subcutaneous implantable catheter having an intravascular indwelling tube 6 made of segmented polyurethane and an intratissue indwelling tube 7 made of silicone rubber as shown in FIG. Was implanted so as to enter the upper mesenteric vein of the goat. Post-operative treatment was performed in the same manner as the comparative example. After surgery
Even on the 82nd day, the tube lumen was still open and the drug could be injected intravenously.

In each of the comparative example and the example, the tube inserted into the blood vessel had an outer diameter of 2.1 mm and an inner diameter of 1.0 mm.

(Effect of the Invention) The catheter according to the present invention is composed of a tube formed of an antithrombotic material such as polyurethane in the blood vessel and a tube formed of a tissue compatible material such as silicone rubber in the tissue. Therefore, blood vessels may be blocked by thrombus,
It has features such that the lumen of the tube is not clogged, and it is possible to safely inject a drug or nutrient over a long period of time.

[Brief description of drawings]

FIG. 1 is a state diagram showing insertion of a percutaneous implantation catheter according to the present invention, and FIG. 2 is an insertion state diagram of a conventional percutaneous implantation catheter. In the figure, reference numeral 1 is a tube for indwelling in a blood vessel, 2 is a flange portion, 3 is a connecting tube, 4 is a puncture portion, 6 is a tube for indwelling blood vessel, 7 is a tube for indwelling tissue, and 8 is a connector. Show.

Claims (3)

[Scope of utility model registration request] 1. A catheter comprising a drug introduction part, an intracorporeal indwelling tube, and an intravascular indwelling tube, wherein the intratissue indwelling tube is made of silicone rubber, and the intravascular indwelling tube is a polyurethane-based material. A percutaneous transplantation type drug infusion catheter formed by. 2. The catheter according to claim 1, wherein the intracorporeal indwelling tube and the intravascular indwelling tube are connected by a connector. 3. The catheter according to claim 1, wherein the distal end portion of the intravascular indwelling tube is formed obliquely with respect to the axial direction of the tube.