JP7307835B2 - aqueous composition - Google Patents

Description

The present invention relates to an aqueous composition, and more particularly, an aqueous composition containing nicotinamide, a water-soluble polysaccharide, a polyhydric alcohol and a monohydric lower alcohol, which provides a fresh feeling of use, no squeaky feeling, and an aftertaste. The present invention relates to an aqueous composition which is excellent in non-sticky skin and excellent in the effect of suppressing the precipitation of nicotinic acid amide crystals after water evaporation.

The skin develops spots, wrinkles, sagging, pigmentation, etc. due to internal factors such as aging and stress, and external factors such as ultraviolet rays and dry air. Above all, morphological changes such as wrinkles and sagging greatly affect the impression of appearance, and many people desire improvement. Many drugs have been proposed to prevent and improve such wrinkles and sagging. Among these, nicotinic acid amide is a vitamin and is highly safe, has an effect of improving rough skin and keratin, and is known to improve skin firmness and elasticity (for example, Patent Document 1). , 2). Furthermore, nicotinic acid amide is known to have a whitening effect in addition to rough skin improving effect and keratin improving effect (see, for example, Patent Document 3). However, it has been known that when a large amount of nicotinic acid amide is contained, there is an undesirable feel during use, such as a feeling of stickiness (see, for example, Patent Documents 2 and 4). In addition, when using a composition containing more than 1% by mass of nicotinamide, crystals of nicotinamide may precipitate on the skin surface or on the side of a container where the composition drips. (See Patent Document 5, for example).

JP-A-10-130135 JP 2012-041302 A JP 2007-176810 A Japanese Patent Publication No. 2003-502435 Japanese Patent Publication No. 2002-537241

However, Patent Documents 2 and 4, which attempt to reduce stickiness, have concerns that crystals may precipitate when a large amount of nicotinic acid amide is contained. On the other hand, Patent Document 5, which attempts to suppress crystal precipitation, uses a cation-containing polymer, but the stickiness increases and the feeling of use is poor. In addition, if a large amount of glycol is added to retain moisture in order to suppress the crystals of nicotinic acid amide, there is a problem that the refreshing feeling of use is lost, resulting in a formulation with strong stickiness on the skin after use. there were.

That is, there is no known aqueous composition that contains nicotinic acid amide, is excellent in a fresh feel after use, does not have a squeaky feeling, and is not sticky on the skin after use, and is capable of suppressing the precipitation of nicotinic acid amide crystals after water evaporation. is.

In view of such circumstances, the present inventors have made intensive studies to solve the above problems, and as a result, by blending a monohydric lower alcohol and a polyhydric alcohol in a nicotinic acid amide formulation, it has a fresh feeling. It has been found that the precipitation of nicotinic acid amide crystals can be suppressed in spite of this. In addition, by blending one or more water-soluble polysaccharides selected from the group consisting of white fungus polysaccharides, sodium chondroitin sulfate and proteoglycans, while enhancing the effect of suppressing crystal precipitation, nicotinic acid amide and polysaccharides are added. The present invention was completed based on the discovery that the stickiness and squeakiness of the skin after use due to the use of a functional alcohol can be suppressed.

That is, the present invention provides the following components (A) to (D);
(A) nicotinic acid amide (B) white fungus polysaccharide, sodium chondroitin sulfate and one or more water-soluble polysaccharides selected from the group consisting of proteoglycans (C) polyhydric alcohol (D) monohydric lower alcohol The present invention provides an aqueous composition containing

Furthermore, it relates to an aqueous composition containing component (E) a nonionic surfactant.

Further, the aqueous composition according to claim 1 or claim 2, wherein said component (C) polyhydric alcohol is two or more selected from glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol and polyethylene glycol. .

Further, it relates to an aqueous composition in which the content ratio (A)/(C) of the component (A) and the component (C) is 0.04-5.

Furthermore, it relates to an aqueous composition, which is an external preparation for skin or a cosmetic.

Furthermore, the present invention relates to a nicotinamide crystallization inhibitor containing, as an active ingredient, one or more water-soluble polysaccharides selected from the group consisting of white fungus polysaccharides, sodium chondroitin sulfate and proteoglycans.

The aqueous composition of the present invention provides an excellent fresh feeling in use, no squeaky feeling, no stickiness on the skin after use, and an excellent effect of suppressing the precipitation of nicotinic acid amide crystals after water evaporation.

The present invention will be described in detail below. In this specification, "-" shall mean a range including numerical values before and after it. In addition, numerical values expressed in % are values based on mass unless otherwise specified.

Component (A): Nicotinamide Component (A) nicotinamide in the present invention is an amide of nicotinic acid (vitamin B3/niacin). Nicotinamide is a water-soluble vitamin, a known substance that is one of the vitamin B group, and can be extracted from natural products (such as rice bran) or synthesized by a known method. Specifically, those listed in the Japanese Pharmacopoeia 2008, 15th Edition can be used. It is readily soluble in water and ethanol, and sparingly soluble in diethyl ether. Slightly soluble in polyhydric alcohols and oils.

Although the content of component (A) in the present invention is not particularly limited, it is preferably 0.5 to 10% by mass (hereinafter simply abbreviated as "%"), more preferably 3 to 10%, and even more preferably. is 4-8%. Within this range, it is possible to obtain a feeling of effectiveness in terms of rough skin improving effect and whitening effect, and also obtain satisfactory feeling in terms of feeling after use such as non-stickiness of the skin after use, which is preferable.

Component (B): Tremella fungus polysaccharide, one or more water-soluble polysaccharides selected from the group consisting of sodium chondroitin sulfate and proteoglycan Component (B) Tremella fungus polysaccharide in the present invention is a solvent extracted from mushrooms belonging to Tremella family It is a water-soluble polysaccharide extracted using
Examples of extraction solvents include water, lower alcohols such as ethanol, and polyhydric alcohols such as 1,3-butylene glycol and dipropylene glycol. These solvents may be used singly or in combination of two or more. Among these, it is preferable to use water, hot water, or a mixed solution of a solvent that can be mixed with water at any ratio, such as ethanol or 1,3-butylene glycol, and hot water is more preferable.
Although the extraction method is not particularly limited, for example, a method of mixing a solvent for extraction with white fungus and extracting with heating can be mentioned. The obtained extract can be used as it is, or can be used after being appropriately concentrated, or after being dried into a powder form by spray drying, freeze drying, or the like.
Such component (B) white fungus polysaccharide is not particularly limited, but examples of commercially available products include Tremoist-TP, Tremoist-SL (manufactured by Nippon Fine Chemical Co., Ltd.), white fungus polysaccharide-P (Oriza Yuka Co., Ltd.) made) and the like.

The component (B) of the present invention, sodium chondroitin sulfate, is a sodium salt in which sulfuric acid is bound to a sugar chain consisting of repeating disaccharides of β-DN-acetylgalactosamine and β-D-glucuronic acid. Although the production method and origin are not particularly limited, for example, bones, cartilage, skin, scales of fish such as sharks and salmon, other aquatic animals such as whales and sea cucumbers, and land animals such as cattle, pigs, chickens and horses. etc., are subjected to alkali treatment, enzyme treatment, or the like. It can also be obtained by synthesis, semi-synthesis, fermentation, or the like.
The component (B) sodium chondroitin sulfate is not particularly limited, but examples of commercially available products include sodium chondroitin sulfate (manufactured by Maruha Nichiro Co., Ltd.).

The component (B) proteoglycan in the present invention is a complex polysaccharide in which glycosaminoglycans are covalently bound to a protein core.
The production method and origin are not particularly limited, but examples include a method of extracting, separating and purifying cartilage of fish such as shark and salmon using a solvent.
Such component (B) proteoglycan is not particularly limited, but examples of commercially available products include proteoglycan IPC (manufactured by Ichimaru Farcos Co., Ltd.).

One or two or more of these component (B) water-soluble polysaccharides selected from the group consisting of white fungus polysaccharides, sodium chondroitin sulfate and proteoglycans can be used. Among these, it is more preferable to use Tremella fungus polysaccharide from the standpoints of superior crystallization inhibiting effect, absence of stickiness on the back skin, and absence of squeaky feeling.

Although the content of component (B) in the present invention is not particularly limited, it is preferably 0.0005 to 0.02%, more preferably 0.001 to 0.01%. Within this range, the effect of suppressing the precipitation of nicotinic acid amide crystals is excellent, and satisfactory freshness, non-stickiness of the back skin, and non-squeaky feeling can be obtained, which is preferable.

Component (C): Polyhydric alcohol The component (C) polyhydric alcohol in the present invention has a structure having two or more hydroxyl groups in the molecule. In the present invention, the component (C) is a component that can be expected to have an effect of suppressing crystallization of the component (A) after water evaporation from the aqueous composition, and is not particularly limited as long as it is commonly used in cosmetics. Examples include glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,2-pentanediol, 1,3-propanediol, sorbitol and polyethylene glycol. Among these, glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol and polyethylene glycol (having a number average molecular weight of preferably 200 to 1600) are particularly preferred. Component (C) can be used alone or in any combination of two or more. In particular, the use of two or more is effective in suppressing the precipitation of nicotinic acid amide crystals after evaporation of water and reducing the stickiness of the skin. It is more preferable because it is excellent in lack of smoothness and squeaky feeling. When two or more types are used, one containing at least 1,3-butylene glycol is more preferred, and one containing 1,3-butylene glycol and glycerin is particularly preferred. Furthermore, when 1,3-butylene glycol and glycerin are contained, the content ratio by mass of 1,3-butylene glycol and glycerin is more preferably in the range of 5:1 to 1:5.

Although the content of component (C) is not particularly limited in the present invention, it is preferably 5 to 20%, more preferably 7 to 15%. Within this range, it is possible to obtain an aqueous composition which is excellent in the absence of stickiness on the skin afterward and which is excellent in the effect of suppressing the precipitation of nicotinic acid amide crystals after water evaporation.
In addition, the content mass ratio (A)/(C) of the component (A) and the component (C) is not particularly limited, but is preferably 0.04 to 5, more preferably 0.1 to 1. preferable. Within this range, it is possible to obtain an aqueous composition which is excellent in the effect of suppressing the precipitation of nicotinic acid amide crystals after evaporation of water, and in the freshness of the skin, non-stickiness, and non-squeaky feeling.

Component (D): Monohydric lower alcohol The component (D) monohydric lower alcohol in the present invention has 1 to 5 carbon atoms and has a structure having one hydroxyl group in the molecule. In the present invention, the component (D) dissolves the component (A), suppresses crystal precipitation, and is contained in order to obtain a fresh feeling of use, and is usually used in cosmetics. Examples include, but are not limited to, ethanol and 2-propanol. Component (D) can be used singly or in any combination of two or more. Among these, ethanol is particularly preferable from the viewpoint of freshness.

Although the content of component (D) is not particularly limited in the present invention, it is preferably 5 to 20%, more preferably 7 to 15%. Within this range, it is possible to obtain an aqueous composition which is excellent in freshness and is excellent in non-stickiness of the skin after use.

Component (E): Nonionic Surfactant The aqueous composition of the present invention can further contain component (E) a nonionic surfactant. Component (E) further reduces the squeaky feeling in the aqueous composition of the present invention, and is not particularly limited as long as it is commonly used in cosmetics. Examples include polyglycerin fatty acid esters and sucrose fatty acids Ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene hardened castor Oils, polyoxyethylene fatty acid ethanolamides, polyoxyalkylene-modified silicones, polyoxyalkylenealkyl co-modified silicones, etc., may be mentioned, and one or more of these may be contained in combination.

In particular, HLB 10 to 18 is preferable, and HLB 11 to 16 is more preferable, from the viewpoint of excellent lack of squeaky feeling. The HLB (Hydrophile-Lipophile Balance) value used in the present invention is a value obtained by the Griffin method. Specifically, sucrose laurate (HLB: 17.0), polyoxyethylene polyoxypropylene cetyl ether (20E.O.) (4P.O.) (HLB: 16.5), polyoxyethylene monooleate Sorbitan (20E.O.) (HLB: 15.7), polyoxyethylene hydrogenated castor oil (80E.O.) (HLB: 15.0), polyoxyethylene hydrogenated castor oil (60E.O.) (HLB: 14.0), polyoxyethylene hydrogenated castor oil (40E.O.) (HLB: 12.5), polyoxyethylene isostearate hydrogenated castor oil (50E.O.) (HLB: 12.0), polyoxyethylene polyoxypropylene decyltetradecyl ether (20E.O.) (6P.O.) (HLB: 11.0) and the like. It should be noted that the numerical values in parentheses in the above examples are those of E.I. O.D. ; average number of added moles of ethylene oxide, P.; O.D. ; Indicates the average added mole number of propylene oxide.

Among these, those containing a polyoxyethylene chain as a hydrophilic group are particularly preferable from the viewpoint of being excellent in no squeaky feeling and no stickiness on the back skin. Specific commercial products include Nonion OT-221R (polyoxyethylene sorbitan monooleate (20E.O.)) (HLB: 15.7) (manufactured by NOF Corporation), HCO-60 (polyoxyethylene hardened castor Oil (60 E.O.)) (HLB: 14.0) (manufactured by Nippon Surfactant Kogyo Co., Ltd.), EMALEX RWIS-150 (polyoxyethylene hydrogenated castor oil isostearate (50 E.O.)) (HLB: 12.0) (manufactured by Nippon Emulsion Co., Ltd.), NIKKOL PEN-4620 (polyoxyethylene polyoxypropylene decyltetradecyl ether (20E.O.) (6P.O.)) (HLB: 11.0) (manufactured by Nippon Surfactant Kogyo Co., Ltd.), etc. and can contain one or a combination of two or more thereof.

The content of component (E) in the present invention is not particularly limited, but is preferably 0.01 to 1%, more preferably 0.05 to 0.5%. Within this range, it is possible to obtain an aqueous composition which is excellent in the non-stickiness of the skin after use and which is excellent in the non-squeaky feeling.

In addition to the above components, the aqueous composition of the present invention contains optional components contained in ordinary cosmetics, etc., ie, water, oils, powders, and components other than component (B), to the extent that the effects of the present invention are not impaired. water-soluble polysaccharides, and other water-soluble polymers, film-forming agents, surfactants other than component (E), oil-soluble gelling agents, organically modified clay minerals, resins, coloring agents, ultraviolet absorbers, preservatives agents, antibacterial agents, fragrances, antioxidants, pH adjusters, chelating agents, cosmetic ingredients, and the like.

Water is not particularly limited as long as it is commonly used in cosmetics and the like. In addition to water, purified water, hot spring water, deep-sea water, or steam-distilled water from plants may be used, and one or more of them may be appropriately selected and used as necessary.

The oil agent is not particularly limited as long as it is commonly used in cosmetics and the like. The content of the oil in the present invention is not particularly limited, but is preferably 1% or less, more preferably 0.5% or less. Within this range, an aqueous composition with more excellent freshness can be obtained.

The aqueous composition of the present invention has an aqueous component content of 90% or more, and can be used in combination with other components to form various dosage forms. Specifically, various dosage forms such as liquid, gel, paste, cream, and solid may be used, and liquid and gel are more preferable.

The aqueous composition of the present invention can be used as cosmetics or external preparations for skin. Uses of cosmetics include lotions, milky lotions, creams, beauty essences, massage cosmetics, pack cosmetics, hand creams, body lotions, body creams, makeup cosmetics, makeup base cosmetics, eye creams, It is suitable as a sunscreen, hair cream, hair wax, etc., and is more preferably used as a lotion or beauty essence. Examples of the method of use include a method of using hands, fingers, cotton, and a method of impregnating a non-woven fabric or the like. Examples of the use of external preparations for skin include liquids for external use, gels for external use, creams, ointments, liniments, lotions, poultices, plasters, sprays, and aerosols. In addition, the method of use thereof is the same as that of the cosmetics described above.

EXAMPLES The present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these. Unless otherwise specified, the content is shown in % by mass relative to the system containing the component.

Example 1 (Inventive Products 1 to 29) and Comparative Products 1 to 4: Aqueous Lotions Aqueous lotions having the formulations shown in Tables 1 to 3 below were prepared to improve the effect of suppressing crystal precipitation, freshness, and stickiness of the back skin. The following methods were used to evaluate the smoothness and the lack of squeaky feeling. The results are also shown in Tables 1-3.

(Evaluation item)
stomach. Effect of suppressing crystal precipitation b. Freshness c. Non-stickiness of back skin. lack of squeakiness

(Evaluation method)
[D. Evaluation of crystal precipitation suppression effect]
For the evaluation of the effect of suppressing crystal precipitation, a thin film of the sample was drawn on a glass plate with a 6-mil doctor blade, air-dried at 20°C for 15 minutes, and each sample was observed under a microscope. The state of crystal precipitation was observed with a polarizing filter at 40x optical microscope observation.
<Judgment Criteria>
(judgment): (evaluation)
A: No precipitation of crystals was observed.
◯: Precipitation of crystals is observed in part of the observed area.
x: Precipitation of crystals is observed over the entire observation area.

[Regarding b, ha, d (sensory evaluation)]
A panel of 10 women in their 20s to 40s who had undergone sensory evaluation training and were able to perform evaluations according to a certain standard was selected. A panel of specialists applied the water-based lotions of the above examples and comparative examples to the entire face, and whether or not they felt a fresh feeling when they were spread over the skin (b. freshness), and after applying the water-based lotions. (C. Absence of stickiness on the skin after use), and whether the water-based cosmetic composition feels squeaky when applied on the skin (D. Absence of squeaky feeling). An absolute evaluation was performed on a 5-grade scale and a score was assigned. For each sample, the average score was calculated from the total scores of all the panel members, and the evaluation was made according to the following 4-grade criteria.

(B. Evaluation of freshness)
Absolute Evaluation Criteria (Rating): (Rating)
5 points: feels very fresh 4 points: feels somewhat fresh 3 points: normal 2 points: does not feel slightly fresh 1 point: does not feel fresh
◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Somewhat poor ×: 2 points or less: Poor

(C. Evaluation of non-stickiness of back skin)
Absolute Evaluation Criteria (Rating): (Rating)
5 points: No stickiness 4 points: Almost no stickiness 3 points: Slightly sticky 2 points: Sticky 1 point: Very sticky
◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Somewhat poor ×: 2 points or less: Poor

(D. Evaluation of absence of squeaky feeling)
Absolute Evaluation Criteria (Rating): (Rating)
5 points: No squeaky feeling 4 points: Almost no squeaky feeling 3 points: Slightly squeaky feeling 2 points: Squeaky feeling 1 point: Very squeaking feeling average score)
◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Somewhat poor ×: 2 points or less: Poor

(Production method)
A: Ingredients 1-12 and 16-17 are uniformly mixed at room temperature.
B: Components 13 to 15 are uniformly mixed and dissolved at 50°C.
C: B was added to A at room temperature to obtain an aqueous lotion.

As is clear from the results in Tables 1 to 3, the aqueous skin lotions of the products 1 to 29 of the present invention have an effect of suppressing crystal precipitation, freshness, and non-stickiness of the back skin compared to the aqueous skin lotions of the comparative products 1 to 4. , and the absence of squeaky feeling.
On the other hand, the comparative product 1 that does not contain the component (B) is particularly inferior in the effect of suppressing crystal precipitation and the lack of squeaky feeling, and even in the comparative product 2 to which sodium hyaluronate is added instead, the effect of suppressing crystal precipitation is particularly good. In addition, it was inferior to the product of the present invention in terms of lack of squeaky feeling.
Moreover, the comparative product 3, which does not contain the component (C), was inferior to the product of the present invention particularly in terms of the effect of suppressing crystal precipitation, the freshness, and the absence of a squeaky feeling. Comparative product 4, which does not contain component (D), was inferior to the product of the present invention, particularly in terms of freshness and non-stickiness of the back skin.

Example 2: Aqueous emulsion (ingredient) (%)
1.1,3-butylene glycol 12.0
2. Glycerin 5.0
3. Remaining purified water 4. Nicotinamide 6.0
5. Polyethylene glycol monostearate (40 E.O.) 0.5
6. Sorbitan sesquioleate 0.1
7. Hydrogenated lecithin 0.1
8. Cholesteryl hydroxystearate (Note 7) 1.0
9. Vaseline 1.0
10. α-olefin oligomer 1.0
11. Shea butter 0.5
12. Dimethylpolysiloxane (10CS) 0.5
13. Ceramide 3 0.1
14. Astaxanthin 0.1
15. Tocopherol 0.01
16. Cetostearyl alcohol 1.0
17. behenyl alcohol 0.5
18. Methyl paraoxybenzoate 0.1
19. Tremella fungus polysaccharide (Note 8) 0.01
20. Acrylic acid-alkyl methacrylate copolymer (Note 9) 0.1
21. Xanthan gum 0.1
22. sodium hydroxide 0.03
23. Ethanol 5.0
24. Perfume 0.2
25. Purified water 10.0
Note 7) Saracos HS (manufactured by Nisshin OilliO Co., Ltd.)
Note 8) TREMOIST-TP (manufactured by Nippon Fine Chemical Co., Ltd.)
Note 9) Carbopol ULTREZ21 (manufactured by LUBRIZOL)

(Production method)
A: Components 1 to 5 are uniformly dissolved and mixed at 70°C.
B: Components 6 to 17 are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After adding and mixing components 18 to 25 to C, the mixture was cooled to 40°C to obtain an aqueous emulsion.

The aqueous milky lotion of Example 2 was excellent in terms of crystal precipitation suppressing effect, freshness, non-stickiness of the back skin, and non-squeaky feeling.

Example 3: Aqueous beauty essence (ingredient) (%)
1.1,3-butylene glycol 5.0
2. Dipropylene glycol 5.0
3. Tripropylene glycol 3.0
4. Remaining purified water 5. Nicotinamide 4.0
6. Polyoxyethylene sorbitan monooleate (20E.O.) 0.1
7. Polyethylene glycol monostearate (55E.O.) 0.25
8. Macadamia nut oil fatty acid phytosteryl (Note 10) 1.0
9. Light liquid isoparaffin (Note 11) 2.0
10. Dimethylpolysiloxane (6CS (25°C)) 1.0
11. Cholesterol 0.1
12. Tocopherol 0.01
13. Cetostearyl alcohol 0.5
14. Methyl paraoxybenzoate 0.1
15. Tremella fungus polysaccharide (Note 8) 0.01
16. Carbomer 0.15
17. (Na acrylate/Na acryloyldimethyltaurate) copolymer (Note 12) 0.1
18. sodium hydroxide 0.05
19. Ethanol 5.0
20. Collagen 0.1
21. Elastin 0.1
22. Hyaluronic acid Na 0.1
23. Perfume 0.05
24. Purified water 10.0
Note 10) PLANDOOL-MAS (manufactured by Nippon Fine Chemical Co., Ltd.)
Note 11) Chloratum LES (manufactured by Croda)
Note 12) SIMULGEL EG (manufactured by SEPIC)

(Production method)
A: Components 1 to 5 are uniformly dissolved and mixed at 70°C.
B: Components 6 to 13 are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After adding and mixing components 14 to 24 to C, the mixture was cooled to 40°C to obtain an aqueous beauty essence.

The water-based beauty essence of Example 3 was excellent in terms of crystal precipitation suppressing effect, freshness, non-stickiness of the back skin, and non-squeaky feeling.

Example 4: Lotion (component) (%)
1.1,3-butylene glycol 10.0
2. Glycerin 5.0
3. Diglycerin 0.5
4. Remaining purified water 5. Nicotinamide 6.0
6. Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (Note 13) 0.5
7. Betaine (Note 14) 0.1
8. Erythritol 0.1
9. Methyl paraoxybenzoate 0.1
10. Disodium edetate 0.05
11. Tremella fungus polysaccharide (Note 8) 0.01
12. Acrylic acid-alkyl methacrylate copolymer (Note 15) 0.1
13. Alcaligenes-produced polysaccharide 0.1
14. (PEG-240/decyltetradeceth-20/HDI) copolymer (Note 16) 0.1
15. Carbomer 0.1
16. Xanthan gum 0.1
17. sodium hydroxide 0.03
18. Purified water 10.0
19. Polyoxyethylene hydrogenated castor oil isostearate (Note 17) 0.1
20. Astaxanthin 0.1
21. Polyoxyethylene polyoxypropylene decyltetradecyl ether (Note 18) 0.1
22. Ethanol 10.0
23. Menthol 0.01
24. Perfume 0.2
Note 13) NeosolueTM-Aquilio (manufactured by Nippon Fine Chemical Co., Ltd.)
Note 14) Amino coat (manufactured by Asahi Kasei Finechem)
Note 15) Carbopol 1382 (manufactured by LUBRIZOL)
Note 16) ADEKA NOL GT-700 (manufactured by ADEKA)
Note 17) NIKKOL RWIS-150 (manufactured by Nippon Emulsion Co., Ltd.)
Note 18) NIKKOL PEN-4620 (manufactured by Nippon Surfactant Industry Co., Ltd.)

(Production method)
A: Components 1 to 10 are uniformly dissolved and mixed.
B: Components 19 to 24 are uniformly dissolved and mixed.
C: B is added to A and mixed.
D: A lotion was obtained by adding components 11 to 18 to C and mixing them.

The lotion of Example 4 was excellent in terms of crystal precipitation suppressing effect, freshness, non-stickiness of the back skin, and non-squeaky feeling.

Example 5: Aqueous hand gel (ingredient) (%)
1.1,3-butylene glycol 1.0
2. Glycerin 1.0
3. Remaining purified water 4. Nicotinamide 8.0
5. Methyl paraoxybenzoate 0.1
6. Disodium edetate 0.05
7. Tremella fungus polysaccharide (Note 8) 0.01
8. Acrylic acid-alkyl methacrylate copolymer (Note 15) 0.1
9. Carbomer 0.1
10. sodium hydroxide 0.03
11. Purified water 10.0
12. Ethanol 50.0
13. Perfume 0.2

(Production method)
A: Components 1 to 6 are uniformly dissolved and mixed.
B: Components 12 and 13 are uniformly dissolved and mixed.
C: B is added to A and mixed.
D: An aqueous hand gel was obtained by adding components 7 to 11 to C and mixing them.

The hand gel of Example 5 was excellent in all of crystal precipitation suppressing effect, freshness, non-stickiness of the back skin, and non-squeaky feeling.

Example 6: Aqueous cleansing (ingredient) (%)
1. Remaining amount of purified water 2. Citric acid 0.1
3. Sodium citrate 0.1
4. Dipropylene glycol 15.0
5.1,3-butylene glycol 5.0
6. Glycerin 2.0
7. Tremella fungus polysaccharide (Note 8) 0.01
8. Polyquaternium-51 (Note 19) 0.5
9. Nicotinamide 4.0
10. Astaxanthin 0.1
11. Ethanol 1.0
12. Methyl paraoxybenzoate 0.1
13. PEG/PPG/polybutylene glycol-8/5/3 glycerin (note 20) 5.0
14. Polyoxyethylene glyceryl triisostearate (20 E.O.) (Note 21) 1.0
15. Ascorbyl tetra-2-hexyldecanoate (Note 22) 0.01
16. Polyoxyethylene coconut oil fatty acid monoethanolamide (10E.O.) (Note 23) 0.1
17. Polyoxyethylene polyoxypropylene decyltetradecyl ether (Note 18) 0.1
Note 19) LIPIDURE-PMB (manufactured by NOF Corporation)
Note 20) Willbride S-753D (manufactured by NOF Corporation)
Note 21) M fine oil ISG-20T (manufactured by Miyoshi Oil Co., Ltd.)
Note 22) NIKKOL VC-IP (manufactured by Nikko Chemicals)
Note 23) Amizet 10C (manufactured by Kawaken Fine Chemicals)

(Production method)
A: Ingredients 1 to 9 are uniformly mixed at room temperature.
B: Ingredients 10 to 17 are uniformly mixed at room temperature.
C: Aqueous cleansing was obtained by adding and mixing B with A at 35°C.

The water-based cleansing of Example 6 was excellent in all of crystal precipitation suppressing effect, freshness, non-stickiness of the back skin, and non-squeaky feeling.

Example 7: Aqueous cleansing sheet (component) (%)
1. Remaining amount of purified water 2. Sodium dihydrogen phosphate 0.05
3. Sodium monohydrogen phosphate 0.05
4. Citric acid 0.01
5. Disodium edetate 0.05
6.1,3-butylene glycol 5.0
7. Dipropylene glycol 10.0
8. Polyethylene glycol 400 0.5
9. Tremella fungus polysaccharide 0.01
10. Phenoxyethanol 0.5
11. Tocopherol 0.01
12. Nicotinamide 4.0
13. Astaxanthin 0.1
14. Ethanol 5.0
15. Methyl paraoxybenzoate 0.5
16. Polyoxyethylene glyceryl triisostearate (20 E.O.) (Note 21) 1.0
17. Polyoxyethylene coconut oil fatty acid monoethanolamide (10E.O.) (Note 23) 0.1
18. Polyoxyethylene sorbitan monooleate (20 E.O.) (Note 24) 0.1
19. Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (Note 13) 0.5
20. Perfume 0.2
Note 24) Rhodol TW-O 120V (manufactured by Kao Chemical Co., Ltd.)

(Production method)
A: Ingredients 1 to 12 are uniformly mixed at room temperature.
B: Ingredients 13 to 20 are uniformly mixed at room temperature.
C: A nonwoven fabric was impregnated with a composition obtained by adding B to A at room temperature and emulsifying to obtain an aqueous cleansing sheet.

The water-based cleansing sheet of Example 7 was excellent in terms of crystal precipitation suppressing effect, freshness, non-stickiness of the back skin, and non-squeaky feeling.

Claims (5)

the following components (A) to ( E );
(A) nicotinic acid amide 4-8% by mass
(B) one or more water-soluble polysaccharides selected from the group consisting of white fungus polysaccharides, sodium chondroitin sulfate and proteoglycans 0.0001 to 0.1% by mass
(C) 0.5 to 25% by mass of polyhydric alcohol
(D) 5 to 50% by mass of monohydric lower alcohol
(E) HLB 10 to 18 nonionic surfactant 0.01 to 1% by mass
An aqueous composition containing 2. The aqueous composition according to claim 1, wherein said component (C) polyhydric alcohol is two or more selected from glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol and polyethylene glycol. 3. The aqueous composition according to claim 1 , wherein the content ratio (A)/(C) of the component (A) and the component (C) is 0.04 to 5. The aqueous composition according to any one of claims 1 to 3 , which is an external preparation for skin or a cosmetic. A composition containing 4 to 8% by mass of nicotinamide, one or more water-soluble polysaccharides selected from the group consisting of white fungus polysaccharides, sodium chondroitin sulfate and proteoglycans, polyhydric alcohols, and monohydric and a nonionic surfactant with an HLB of 10 to 18 , the content of the water-soluble polysaccharide is 0.0001 to 0.1% by mass relative to the mass of the composition , and the poly The content of the hydric alcohol is 0.5 to 25% by mass relative to the mass of the composition, the content of the monohydric lower alcohol is 5 to 50% by mass relative to the mass of the composition, and the HLB is 10 to 18. A method for suppressing crystal precipitation of nicotinic acid amide, wherein the content of the nonionic surfactant is 0.01 to 1% by mass with respect to the mass of the composition .