JP2012041302A - Skin cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin cosmetic capable of adjusting skin quality by improving roughness of skin, especially dryness, and improving skin tension and elasticity, and having excellent feeling of use without stickiness.SOLUTION: This skin cosmetic contains following ingredients (A)-(C): (A) two or more kinds selected from D-pantothenyl alcohol, glycyrrhizic acid and its derivative, glycyrrhetinic acid and its derivative, γ-orizanol, diisopropylamine dichloroacetate, γ-aminobutyric acid, tranexamic acid and its derivative, and nicotinic acid amide; (B) N-acetylglucosamine; and (C) acidic mucopolysaccharide.

Description

The present invention relates to a skin cosmetic that improves rough skin, in particular roughness, improves the quality of the skin, improves the firmness and elasticity of the skin, and is excellent in use feeling without stickiness.

The epidermis (horny layer) located in the outermost layer of the skin is an organ that functions as a barrier that separates the living body from the outside world and prevents various external substances from entering the living body and preventing excessive evaporation of moisture from inside the living body. The barrier function of the skin is temporarily impaired due to washing with surfactants, ultraviolet rays from sun exposure, excessive dry environment, etc., and this decrease in barrier function is transdermal water transpiration (TEWL) in terms of skin physiology It is grasped in the form of an increase in This increased state of TEWL is so-called rough skin, and the disorder of the skin state is repeated due to various causes. By normalization, itching and pigmentation due to an inflammatory response and a vicious circle due to the occurrence of new rough skin occur. In addition, it progresses to phenomena such as skin dryness, exfoliation of keratinocytes, wrinkles due to skin elasticity and reduced elasticity, and tarmi, which are general signs of skin aging. Therefore, it is extremely important to prevent rough skin as a care for preventing various skin conditions which are not cosmetically desirable.

In order to prevent such rough skin, various methods and cosmetics have been proposed. For example, a method of supplementing the skin barrier function using a moisturizing ingredient, a component that improves the skin function, and gradually improving the skin function. The method of making it improve is mentioned. As a method of supplementing the skin barrier function by the moisturizing component, for example, a highly hydrating moisturizing component such as a polyhydric alcohol or a saccharide, and a skin occlusive oil component such as liquid paraffin or ester oil are blended. It is common practice to adjust the amount. Furthermore, as cosmetics having a higher effect than these moisturizing ingredients, cosmetics containing hydroxycitric acid derivatives (see, for example, Patent Document 1), cosmetics containing sphingolipids extracted from plants as active ingredients ( For example, refer to Patent Document 2), cosmetics containing a specific organic acid including citric acid and ethyl glucoside (for example, refer to Patent Document 3) and the like have been proposed as methods for enhancing the moisturizing function.

As a method using various drugs for improving skin function as active ingredients, for example, cosmetics that improve the rough skin by suppressing the release of various plant extracts and stem cell factors (see, for example, Patent Document 4), endorphins. Anti-skin rough / anti-aging cosmetics (for example, see Patent Document 5) due to cell-activating action of a like-like substance, and cosmetics containing carnitine chloride to promote proliferation of epidermal keratinocytes (for example, see Patent Document 6). Cosmetics (for example, see Patent Document 7) and the like in which a specific compound and an anti-inflammatory agent such as glycyrrhizic acid are combined are disclosed.

JP 2007-254388 A JP 2006-022006 JP JP-A-2005-314310 JP 2006-056902 A JP 2006-008538 A JP-A-11-302143 Japanese Laid-Open Patent Publication No. 2005-53785

All of the above conventional techniques have been improved as skin cosmetics for the purpose of improving rough skin, but any of the methods for supplementing the skin barrier function with moisturizing ingredients is said to have sufficient skin moisture retention ability. It cannot be said that there is little keratin improvement effect, and when using an occlusive agent with an oil agent, there are drawbacks that give it an unpleasant feel such as oiliness and stickiness. A large amount had to be blended, resulting in an unpleasant feeling with a strong stickiness. Further, although the rough skin condition is temporarily improved by the moisturizing effect, when it is removed by washing or the use is stopped, it easily returns to the original skin condition and has not been fully satisfactory. In addition, the method of blending various drugs for improving skin function as an active ingredient cannot be said to have sufficient skin moisture retention ability, and it takes a long period of use before the keratin improving effect is exerted. It has not yet reached its function of restoring elasticity. For this reason, there has been a strong demand for skin cosmetics that improve rough skin, in particular the roughness, improve the quality of the skin, improve the firmness and elasticity of the skin, and have a non-sticky feel.

As a result of diligent research to achieve the above object, the present inventors have found that D-pantothenyl alcohol, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, γ-oryzanol, diisopropylamine dichloroacetate, γ-aminobutyric acid, Contains two or more selected from tranexamic acid and its derivatives, nicotinic acid amide, N-acetylglucosamine, acidic mucopolysaccharide, improves skin roughness such as skin roughness and improves skin quality, elasticity and elasticity of the skin The present invention was completed by finding that it was improved and excellent in feel without stickiness.

That is, the present invention relates to (A) D-pantothenyl alcohol, glycyrrhizic acid and derivatives thereof, glycyrrhetinic acid and derivatives thereof, γ-oryzanol, diisopropylamine dichloroacetate, γ-aminobutyric acid, tranexamic acid and derivatives thereof, nicotinamide 2 or more types selected from (B) N-acetylglucosamine and (C) acidic mucopolysaccharide.

The skin cosmetic composition of the present invention has an excellent effect on the feeling of use with no stickiness, improving rough skin, especially the roughness, improving the skin quality, improving the firmness and elasticity of the skin.

Hereinafter, the configuration of the present invention will be described in detail. It is necessary to combine two or more components (A) used in the present invention, and the synergistic effect can improve rough skin, improve skin quality, improve skin firmness and elasticity, and D-pantothenyl alcohol. Glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, γ-oryzanol, diisopropylamine dichloroacetate, γ-aminobutyric acid, tranexamic acid and its derivatives, and nicotinic acid amide in combination.

D-pantothenyl alcohol is an alcohol-type derivative of pantothenic acid and is generally synthesized by a condensation reaction of D-pantolactone and 3-aminopropanol. When applied to the skin and absorbed through the skin, it changes to pantothenic acid and exhibits vitamin activity. D-pantothenyl alcohol can be used without particular limitation as long as it is usually used in pharmaceuticals, quasi drugs, and cosmetics.

Glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives are produced from glycyrrhizin extracted from rhizomes and roots of licorice or its related plants, and are generally known to have anti-inflammatory and anti-allergic effects. Yes. Glycyrrhizic acid and its derivatives and glycyrrhetinic acid and its derivatives can be used without particular limitation as long as they are usually used in pharmaceuticals, quasi drugs and cosmetics. Glycyrrhizic acids can be synthesized by known methods or can be obtained as commercial products. Examples of the derivatives of glycyrrhizic acid or glycyrrhetinic acid used in the present invention include ester derivatives with fatty acids such as stearyl acid. Examples of salts of glycyrrhizic acid or glycyrrhetinic acid include alkali metal salts such as sodium and potassium, ammonium salts, etc., for example, glycyrrhizic acid, monoammonium glycyrrhizinate, stearyl glycyrrhizinate, dipotassium glycyrrhizinate, glycyrrhetic acid, glycyrrhetic acid Stearyl etc. are mentioned. Moreover, glycyrrhizic acids may be blended in the hair restorer of the present invention as herbal medicines such as licorice, herbal powders or herbal extracts containing them. The glycyrrhizic acid is preferably a salt of glycyrrhizic acid, more preferably an alkali metal salt of glycyrrhizic acid, and particularly preferably dipotassium glycyrrhizinate.

γ-Oryzanol is a ferulic acid triterpene alcohol ester, and its origin is not particularly limited. Even if it is obtained by extraction and purification from rice (Oryza sativa Linne) seed coat, it is synthesized in whole or in part. May be obtained. γ-Oryzanol can be used without particular limitation as long as it is usually used in pharmaceuticals, quasi drugs, and cosmetics.

Diisopropylamine dichloroacetate and γ-aminobutyric acid are known to have a blood circulation promoting action or cell activation action, and are known compounds (for example, Japanese Patent No. 1413603, Japanese Patent No. 1197012, Japanese Patent No. 1527136). As long as it is normally used in pharmaceuticals, quasi-drugs, and cosmetics.

Tranexamic acid and derivatives thereof and derivatives thereof can be used without particular limitation as long as they are usually used in pharmaceuticals, quasi drugs, and cosmetics. Specifically, tranexamic acid and its derivative salts (metal salts such as magnesium salt, calcium salt, sodium salt and potassium salt, phosphate, hydrochloride, hydrobromide, sulfate, etc.), tranexamic acid and its derivatives Esters (vitamin A acid ester, vitamin A ester, vitamin E ester, vitamin C ester, vitamin D ester, etc .; phenyl ester; hydroquinone ester; gentisic acid ester, etc.), amides of tranexamic acid and its derivatives ( Methyl amide or a salt thereof); and dimers of tranexamic acid and its derivatives.

Nicotinic acid amide is one of the vitamin B complexes, and can be used without particular limitation as long as it is usually used in pharmaceuticals, quasi drugs, and cosmetics.

Among the components (A) used in the present invention, particularly preferred are glycyrrhizic acid having an anti-inflammatory effect and derivatives thereof, one or more of glycyrrhetinic acid and derivatives thereof, and D-pantothenyl alcohol having a cell activating effect, γ- One or more aminobutyric acid, tranexamic acid and its derivatives, and nicotinic acid amide are selected and combined.

The content of the component (A) used in the present invention is preferably 0.01 to 10% by mass (hereinafter, simply referred to as%) in the total composition as a total amount of two or more, more preferably 0.8. 2-2%. If it is less than 0.01%, a sufficient rough skin improvement effect may not be obtained, and if it exceeds 10%, the stability of the preparation and an excellent feeling of use may be impaired.

Component (B) N-acetylglucosamine used in the present invention is a kind of a typical natural amino sugar, and it is not particularly limited as long as it is usually used in pharmaceuticals, quasi drugs and cosmetics. it can. It is not limited to any products such as synthetic products, fermentation products, degradation products obtained from chitin degradation such as crabs and shrimp.

Content of the component (B) used by this invention becomes like this. Preferably it is 0.01 to 10% in a whole composition, More preferably, it is 0.05 to 1%. If it is less than 0.01%, a sufficient rough skin improvement effect may not be obtained, and if it exceeds 10%, the stability of the preparation and an excellent feeling of use may be impaired.

Examples of the component (C) acidic mucopolysaccharide used in the present invention include hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate, and salts thereof, and one or more of them can be used. Can be combined. Among these acidic mucopolysaccharides, hyaluronic acid and salts thereof, chondroitin sulfate and salts thereof are preferable. Also,

Content of the component (C) used by this invention becomes like this. Preferably it is 0.01 to 10% in a whole composition, More preferably, it is 0.1 to 1%. If it is less than 0.01%, a sufficient rough skin improvement effect may not be obtained, and if it exceeds 10%, stickiness or the like may occur, and an excellent usability may be impaired.

The skin cosmetic of the present invention contains the above-described components as essential components, but other components such as an anionic surfactant and an amphoteric interface are included in the composition as long as the object of the present invention is not impaired. Activators, nonionic surfactants, adhesives, oils, powders (dyes, resins, pigments), preservatives, fragrances, moisturizers, physiologically active ingredients, salts, solvents, antioxidants, chelating agents, pearlizing Components such as an agent, a neutralizer, a pH adjuster, an insect repellent, and an enzyme can be appropriately blended. Specific examples of other blending components are shown below, but are not limited thereto.

Examples of the anionic surfactant include linear or branched fatty acid salts, α-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, alkyl ether sulfates, Alkylamide sulfate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkylamide ether sulfate, alkyl phosphate, alkylamide phosphate, alkyloylalkyl taurine salt, N-acyl amino acid salt, sulfosuccinate, Examples thereof include fluoroalkyl phosphate esters.

Examples of amphoteric surfactants include glycine type, aminopropionic acid type, carboxybetaine type, sulfobetaine type, sulfonic acid type, sulfuric acid type, and phosphoric acid type.

Nonionic surfactants include fatty acid alkanolamide, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkyl ester, sucrose fatty acid ester, polyglycerin fatty acid ester, alkyl An amine oxide etc. are mentioned.

Examples of the oil agent include volatile and non-volatile oil agents, solvents, and resins that are usually used in cosmetics, and may be in the form of liquid, paste, or solid at room temperature. Examples of oils include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, octyldodecanol, fatty acids such as isostearic acid, undecylenic acid, oleic acid, myristyl myristate, hexyl laurate, myristine Octyldodecyl acid, decyl oleate, isopropyl myristate, hexyl decyl dimethyloctanoate, glyceryl monostearate, glyceryl trioctanoate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, cholesteryl stearate, Cholesterol esters such as cholesteryl oleate and branched fatty acid cholesteryl, hydrocarbons such as liquid paraffin, petroleum jelly and squalane, lanoli , Reduced lanolin, waxes such as carnauba wax, mink oil, cocoa butter, coconut oil,
Examples thereof include oils and fats such as palm kernel oil, camellia oil, sesame oil, castor oil and olive oil, and silicone oils such as dimethylpolysiloxane, cyclic dimethylpolysiloxane and methylphenylpolysiloxane.

Examples of powders include red No. 201, yellow No. 4, blue No. 1, black No. 401 and other dyes, yellow No. 4 Al lake, yellow No. 203 Ba lake and other lake dyes, nylon powder, silk powder and silicone powder. , Cellulose powder, silicone elastomer spherical powder, resin such as polyethylene powder, yellow iron oxide, red iron oxide, chromium oxide, carbon black, colored pigments such as ultramarine and bitumen, white pigments such as zinc oxide and titanium oxide, talc, Body pigments such as mica, sericite and kaolin, pigments such as pearl pigments such as titanium mica, metal salts such as barium sulfate, calcium carbonate, magnesium carbonate and magnesium silicate, inorganic powders such as silica and alumina, bentonite, smectite, Examples thereof include boron nitride. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, indeterminate, flake-like, spindle-like, etc.).

Examples of the physiologically active ingredient include substances that impart some physiological activity to the skin when applied to the skin. For example, anti-aging agents, UV protection agents, squeeze agents, antioxidants, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, cooling agents, warming agents, vitamins, amino acids, wound healing promoters , Stimulation mitigating agents, analgesics, cell activators, enzyme components and the like.

The skin cosmetic of the present invention can be produced according to a conventional method. Examples of the skin cosmetic of the present invention include basic cosmetics, makeup cosmetics, body cosmetics and the like. The dosage form can also be arbitrarily selected according to the purpose. That is, liquid, cream, gel, emulsion, sheet, aerosol and the like can be mentioned. The skin cosmetics of the present invention are not limited to general cosmetics, and include quasi drugs, designated quasi drugs, topical drugs and the like.

EXAMPLES Next, although this invention is demonstrated in detail based on an Example, it is not limited to this. Prior to the examples, test methods and evaluation methods employed in each example will be described.

(Skin roughness improvement effect test)
A skin roughness improvement effect test was carried out by a panel of 10 people who had rough skin on their faces (parts: cheeks). In the test method, different lotions were applied to the left and right cheeks for one week, and the determination was made the next day after the period. The evaluation criteria are as follows.
(Evaluation criteria)
A: Eight or more panelists recognized that rough skin was improved.
○: 6 or more panelists and less than 8 panelists recognized that rough skin was improved.
Δ: 3 or more and less than 6 panelists recognized that the rough skin was improved.
X: Less than 3 panelists recognized that rough skin was improved.

(Moisturizing effect test by conductance measurement)
The skin conductance was measured before and after application, 30 minutes, 60 minutes and 120 minutes using the forearm of a panel of 10 people, and the moisturizing effect was evaluated from the rate of change. The change rate of the skin conductance can be obtained by the following formula, and the influence on the water absorption and water retention ability of the stratum corneum can be examined. If this change rate is small, the increase of the stratum corneum moisture is increased. Yes, it can be evaluated that the moisturizing effect is high. The evaluation criteria are as follows.
Conductance change rate = (conductance before application) / (conductance after application)
(Evaluation criteria)
◎… Average conductance change rate of 10 panelists: 0 or more and less than 0.1 ○… Average conductance change rate of 10 panelists: 0.1 or more and less than 0.2 Δ… Average conductance change rate of 10 panelists: 0.2 or more and less than 0.3 ×: Average of conductance change rate of 10 panelists: 0.3 or more

(Skin elasticity and elasticity)
Each skin cosmetic was used continuously for 1 week by 10 specialist panels, and the skin elasticity and elasticity after use were evaluated. The evaluation criteria are as follows.
(Evaluation criteria)
◎… 8 or more professional panels recognized that the skin was smooth during and after use.
○: 6 or more and less than 8 specialist panels recognized that the skin was smooth during use and after use.
Δ: 3 or more and less than 6 specialist panels recognized that the skin was smooth during use and after use.
X: Less than 3 specialist panels recognized that the skin was smooth during use and after use.

(No stickiness on the skin)
Evaluation was conducted on the non-stickiness of the skin after use while using each skin cosmetic by 10 professional panels. The evaluation criteria are as follows.
(Evaluation criteria)
◎… 8 or more professional panels recognized that there was no stickiness on the skin during and after use.
○ ... 6 or more and less than 8 specialist panels recognized that there was no stickiness on the skin during and after use.
Δ: 3 or more and less than 6 specialist panels recognized that there was no stickiness on the skin during and after use.
X: Less than 3 professional panels recognized that there was no stickiness on the skin during and after use.

(Examples 1-11, Comparative Examples 1-4)
The skin cosmetics having the formulations shown in Table 1 were prepared and the above tests were performed. The results are also shown in Table 1.

As is clear from Table 1, all the skin cosmetics of the examples using the components of the present invention had excellent performance. On the other hand, the comparative example lacking any of the essential components was inferior in any of the rough skin improvement effect, moisturizing effect, skin firmness / elasticity, and non-stickiness, and could not achieve the object of the present invention.

Hereinafter, other prescription examples of the skin cosmetics of the present invention will be given as examples. As for the skin cosmetics of these examples, each item was examined for the above-described rough skin improvement test, moisturizing test, skin firmness and elasticity, and non-stickiness during use. Also had excellent properties and was good.

Example 12 (skin lotion)
(1) D-pantothenyl alcohol 0.5%
(2) Dipotassium glycyrrhizinate 0.2%
(3) N-acetylglucosamine 0.5%
(4) Sodium chondroitin sulfate 0.5%
(5) Sodium hyaluronate 0.1%
(6) Ethanol 6.0%
(7) Dipropylene glycol 2.0%
(8) Polyethylene glycol 1000 1.0%
(9) Glycerin 1.0%
(10) Maltitol 0.5%
(11) Sorbitol 0.5%
(12) Polyoxyethylene (50) hydrogenated castor oil 0.2%
(13) Polyoxyethylene monolaurate (20) Sorbitan 0.2%
(14) Hydroxypropyl methylcellulose 0.1%
(15) Citric acid 0.05%
(16) Sodium citrate 0.1%
(17) Water-soluble collagen (F) 0.2%
(18) Xanthan gum 0.05%
(19) Disodium edetate 0.01%
(20) 2-ethylhexyl paramethoxycinnamate 0.1%
(21) Phenoxyethanol 0.2%
(22) Ethylhexylglycerin 0.05%
(23) Fragrance 0.01%
(24) Purified water 100%

(Production method) (6) to (13), (20) to (23) are uniformly mixed, and (1) to (5), (14) to (19), and (24) are uniformly mixed. In addition, after stirring sufficiently, the dispenser bottle container was filled to prepare the lotion.

Example 13 (body lotion)
(1) γ-aminobutyric acid 0.5%
(2) D-pantothenyl alcohol 0.2%
(3) Monoammonium glycyrrhizinate 0.3%
(4) N-acetylglucosamine 0.2%
(5) Sodium chondroitin sulfate 0.2%
(6) Sodium hyaluronate 0.05%
(7) Ethanol 7.0%
(8) Dipropylene glycol 5.0%
(9) Polyethylene glycol 4000 1.0%
(10) Polyethylene glycol 1000 0.5%
(11) 1.0% polyglycerol
(12) Maltitol 1.0%
(13) Sorbitol 1.0%
(14) Polyoxyethylene (60) hydrogenated castor oil 0.2%
(15) Xanthan gum 0.1%
(16) Carboxyvinyl polymer 0.8%
(17) Potassium hydroxide 0.05%
(18) Citric acid 0.02%
(19) Sodium citrate 0.07%
(20) Water-soluble collagen (F) 0.3%
(21) Gellan gum 0.02%
(22) Glutamic acid diacetic acid 0.02%
(23) Phenoxyethanol 0.2%
(24) Purified water 100%

(Manufacturing method) A part of (15) to (17) and (24) is uniformly mixed and dispersed, and a mixture obtained by uniformly mixing (7) to (14) is added and dispersed with a homomixer. Next, the remainder of (1) to (6), (18) to (23) and (24) was added, and the mixture was uniformly mixed, dispersed again with a homomixer, filled into a glass container, and body lotion was adjusted. .

Example 14 (milky lotion)
(1) D-pantothenyl alcohol 0.2%
(2) Tranexamic acid 0.2%
(3) Dipotassium glycyrrhizinate 0.1%
(4) γ-Oryzanol 0.1%
(5) N-acetylglucosamine 0.2%
(6) Sodium chondroitin sulfate 0.2%
(7) Sodium hyaluronate 0.1%
(8) Liquid paraffin 13.0%
(9) Lipophilic glyceryl monostearate 2.0%
(10) Vaseline 1.0%
(11) Methyl polysiloxane (5000 cs) 0.5%
(12) Stearic acid 1.0%
(13) Cholesterol 1.0%
(14) Sorbitol 3.0%
(15) Behenyl alcohol 0.5%
(16) Bentonite 0.5%
(17) Sodium N-stearoyl-L-glutamate 0.1%
(18) Glycerin 5.0%
(19) Dipropylene glycol 1.0%
(20) Water-soluble collagen (F) 0.3%
(21) Methylparaben 0.2%
(22) Phenoxyethanol 0.2%
(23) Make the total amount of purified water 100%

(Manufacturing method) (8) to (15) are uniformly dissolved at about 80 ° C, and (16) to (23) are uniformly dissolved at about 80 ° C, and the mixture is dispersed with a homomixer. Then, cooling was performed, (1) to (7) were added at 40 ° C., cooled to 30 ° C., filled into a PET container, and an emulsion was prepared.

Example 15 (body milk)
(1) γ-Oryzanol 0.2%
(2) Diisopropylamine dichloroacetate 0.2%
(3) Nicotinamide 0.5%
(4) N-acetylglucosamine 0.2%
(5) Deltaman sulfate 0.1%
(6) Sodium hyaluronate 0.1%
(7) Ethanol 10.0%
(8) Polyoxyethylene (2) alkyl (12-15) phosphoric acid 0.5%
(9) Polyoxyethylene (2) oleyl ether 0.5%
(10) Liquid paraffin 2.0%
(11) Methyl polysiloxane (100 cs) 2.0%
(12) Squalane 1.0%
(13) Alkyl polyacrylate 0.5%
(14) Carboxyvinyl polymer 0.2%
(15) Potassium hydroxide 0.15%
(16) Disodium edetate 0.05%
(17) Fragrance 0.1%
(18) Phenoxyethanol 0.2%
(19) Make the total amount of purified water 100%

(Production method) (7) to (12) are uniformly dissolved, and (13) to (19) are put into a uniformly dispersed place and dispersed with a homomixer. Next, (1) to (6) were added in order, stirred and filled into a glass container to prepare body milk.

Example 16 (cream)
(1) D-pantothenyl alcohol 0.2%
(2) Dipotassium glycyrrhizinate 0.2%
(3) N-acetylglucosamine 1.0%
(4) Sodium chondroitin sulfate 0.2%
(5) Sodium hyaluronate 0.1%
(6) Octyldodecyl myristate 5.0%
(7) Liquid paraffin 5.0%
(8) Cetostearyl alcohol 5.0%
(9) Isostearic acid hydrogenated castor oil 2.0%
(10) Beeswax 2.0%
(11) Phytosterol 0.5%
(12) Methyl polysiloxane (20 cs) 0.3%
(13) Methylcyclopolysiloxane 2.0%
(14) 1.0% glyceryl monostearate
(15) Sodium cetyl sulfate 1.0%
(16) Water-soluble collagen 1.0%
(17) Phenoxyethanol 0.4%
(18) Sodium edetate 0.2%
(19) 1,2-hexanediol 0.2%
(20) Make the total amount of purified water 100%

(Production method) (6) to (14) are heated to 80 ° C, and (15) to (20) are heated to 80 ° C and dispersed with a homomixer. Next, (1) to (5) were added and dispersed again with a homomixer, cooled to room temperature, and filled into a resin container to prepare a cream.

Example 17 (beauty pack)
(1) D-pantothenyl alcohol 0.5%
(2) Dipotassium glycyrrhizinate 0.1%
(3) N-acetylglucosamine 0.1%
(4) Sodium chondroitin sulfate 0.2%
(5) Heparan sulfate 0.1%
(6) Acrylic acid / alkyl methacrylate copolymer 0.5%
(7) Xanthan gum 0.1%
(8) L-ascorbic acid sodium phosphate 1.0%
(9) (Behenic acid / isostearic acid / eicosanedioic acid) glyceryl 5.0%
(10) Hydrogenated macadamia nut oil 1.0%
(11) Squalane 2.0%
(12) Dipropylene glycol 5.0%
(13) 1,3-propanediol 10.0%
(14) Sodium hydroxide 0.1%
(15) Glycerin 5.0%
(16) Retinol 0.002%
(17) Astaxanthin 0.0005%
(18) Edetate disodium 0.01%
(19) The balance of purified water

(Manufacturing method) (9)-(13) is heated at 50 degreeC, and it disperse | distributes to the mixture of (6), (7), (14)-(19) with a homomixer. (1) to (5) and (8) were added and mixed uniformly, and filled into a bottle container to prepare a beauty pack.

Claims (2)

A skin cosmetic comprising the following components (A) to (C).
(A) Two or more kinds selected from D-pantothenyl alcohol, glycyrrhizic acid and derivatives thereof, glycyrrhetinic acid and derivatives thereof, γ-oryzanol, diisopropylamine dichloroacetate, γ-aminobutyric acid, tranexamic acid and derivatives thereof, and nicotinic acid amide (B) N-acetylglucosamine (C) acidic mucopolysaccharide The skin cosmetic according to claim 1, wherein the component (C) acidic mucopolysaccharide is selected from hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate, and salts thereof.