JP6142343B2 - One-part skin external preparation - Google Patents

Description

The present invention includes at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener, and is mixed with a liquid containing moisture. The present invention relates to a one-part skin external preparation to be used.

  Conventionally, an external preparation for skin containing a synthetic or natural extract having a blood circulation promoting action on the skin has been used.

  These extracts are not effective in a small amount of formulation, and if a large amount of formulation is too irritating to the skin, a topical skin preparation that enhances blood circulation by containing carbon dioxide is proposed. Has been made. Many of these substances generate carbon dioxide by the reaction between an acidic substance and a carbon dioxide generating substance. Therefore, at least one of the two preparations is viscous from the viewpoint of maintaining the carbon dioxide generating ability of the external preparation for a long period of time. A method of mixing and foaming these at the time of use was used. As the form of the two agents, for example, it has been proposed to use an aqueous solution and a solid (Patent Document 1), both of which are viscous substances (Patent Document 2), and a solid and a viscous substance (Patent Document 3).

  The two-part skin external preparation is excellent in terms of ease of manufacture and preservability, but all components are required from the viewpoint of cost reduction and easy handling because the manufacturing cost such as packaging cost is excessive. One-pack type external preparation for skin containing 1 in an agent has been desired.

  By the way, since acidic substances and carbon dioxide generating substances such as carbonates generate carbon dioxide upon contact in the presence of water, in two-part skin external preparations, acidic substances and carbonates are blended into separate agents. , Water can be contained in either one agent or two agents. On the other hand, the one-pack type external preparation for skin is provided as a solid product because it cannot contain moisture from the viewpoint of enhancing the storage stability. For this reason, it is necessary to cause foaming of carbon dioxide gas by mixing the one-part skin external preparation and a liquid containing moisture in a container or the like when used.

  In addition, as a skin external preparation that generates carbon dioxide gas, a type that retains carbon dioxide gas in the preparation by giving the agent a viscosity is well known. In one agent, the thickener can be prepared in a pre-thickened state in water. However, in the case of a one-part skin external preparation, the agent cannot contain moisture as described above. Cannot be prepared in a pre-thickened state in water. And since there are many things that need to be performed under certain conditions when dissolving the thickener, there are two-part skin external preparations in which the supplier of external preparations prepared moisture and thickener under certain conditions in advance. It was adopted. On the other hand, in the case of a one-part skin external preparation, the user mixes moisture during use, so it dissolves instantly in water under various conditions and retains carbon dioxide to obtain a sufficient effect of carbon dioxide or dripping. Therefore, there has been a demand for the realization of an external preparation for skin in which the viscosity required for preventing water is generated immediately after mixing of a liquid containing moisture.

  Furthermore, the amount of thickening agent used in the two-part skin external preparation is blended as it is to produce a one-part skin external preparation. When mixed, the skin external preparation is difficult to dissolve in water-containing liquids and is likely to cause lumps. In addition, it has been found that problems such as a feeling of roughness when applied to the skin, sagging without obtaining sufficient viscosity, loss of adhesion, and impaired blood circulation promoting effects are caused.

JP-A-63-310807 JP 05-229933 A WO99 / 24043

  The present invention has been made in view of the above circumstances, is low in cost, easy to handle by a user, and even if a user mixes a liquid preparation containing a one-component skin external preparation under various conditions, it instantly dissolves. Thus, an object of the present invention is to provide a one-part skin external preparation that has a high carbon dioxide retention amount, has a good feeling of use without rough feeling or sagging, and has an excellent blood circulation promoting action.

  In the one-part skin external preparation containing a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener, the thickener However, by using a hydrophilic protein compound and other thickeners together, it was found that the handling was easy and the feeling of use was good, and the present invention was completed.

  The present invention is a one-part skin external preparation containing at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickening agent. In the external preparation, the thickener is used in combination with a hydrophilic protein compound and other thickeners, and is mixed with a liquid containing moisture at the time of use.

  According to the present invention, it is possible to provide a one-part skin external preparation that is low in cost, easy for a user to handle, has a good feeling of use and an excellent blood circulation promoting action. Furthermore, the one-part skin external preparation of the present invention has an increased amount of thickening agent, contrary to previous knowledge, which can eliminate the feeling of roughness when applied to the skin, and bubbles caused by carbon dioxide generation are less likely to collapse. The amount of gas retained is high, and there is no dripping when applied to the skin, and the effect of promoting the absorption of the active ingredient can be continuously obtained. In addition, by using a hydrophilic protein compound and other thickeners in combination with the thickener, the strength of the bubbles can be increased and the foam can be kept stable for a long period of time, and the skin conditioning effect, especially the smoothness of the skin, can be maintained. In addition, the skin can be moistened, the skin can be moistened, and the skin can be softened.

The increase rate of the volume with respect to the volume before stirring of Examples 1-5 and Comparative Examples 1-4 is represented. The increase rate of the volume with respect to the volume before stirring of Examples 6-7 and Comparative Examples 5-7 is represented. The stratum corneum moisture content after use of Examples 6 to 7 and Comparative Examples 5 to 7 (change rate when the value before use is 1) is shown.

  The one-part skin external preparation of the present invention includes at least a solid acidic substance, a single-part skin external substance containing a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide and a thickener. It is an agent, Comprising: The said thickener uses a hydrophilic protein compound and another thickener together.

  In the one-part skin external preparation of the present invention, the user mixes the one-part skin external preparation and a liquid containing water at the time of use, thereby causing foaming due to the generation of carbon dioxide gas. It is applied and used. Since the external preparation for skin of the present invention is made into one agent, it has a feature that the user can easily handle it at a lower cost than the two-component type. Hereinafter, each component included in the one-part skin external preparation, the one-part skin external preparation, and the production method thereof will be described.

<One-pack type external preparation for skin>
The one-part skin external preparation of the present invention contains an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener. Preferably, the one-part skin external preparation of the present invention does not substantially contain moisture. Here, the term “substantially free of moisture” means that the amount of moisture necessary for the generation of carbon dioxide is produced by the reaction between the acidic substance and the carbon dioxide generating substance during the storage of the one-part skin external preparation of the present invention. Say not including. Specifically, the water content in the one-part skin external preparation of the present invention is preferably 15% or less, more preferably 10% or less, and particularly preferably 8% or less. The one-part skin external preparation of the present invention is preferably a solid composition, more preferably in the form of a solid, granule, fine granule, or powder, and mixed with a liquid containing moisture. It is particularly preferable that it is in the form of granules, fine granules, or powders because of ease of treatment.

<Solid acidic substance>
The solid acidic substance used in the present invention may be either an organic acid or an inorganic acid, and one or more of these are used. Moreover, any dosage form may be used as long as it is solid, but powders such as granules and powders are preferable, and powders are particularly preferable.

  Organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, valeric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid Acids, dicarboxylic acids such as terephthalic acid, acidic amino acids such as glutamic acid and aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid And oxyacids such as tropic acid, ascorbic acid and gluconic acid. Of these, citric acid, ascorbic acid, malic acid, and succinic acid are preferable from the viewpoints of safety and solubility in water.

<Solid carbon dioxide generator>
Various solid carbon dioxide generating substances that generate carbon dioxide gas by reacting with the acidic substance used in the present invention can be used without any particular limitation. Moreover, any dosage form may be used as long as it is solid, but powders such as granules and powders are preferable, and powders are particularly preferable.

  Examples of the carbon dioxide generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate And hydrogen carbonates such as calcium hydrogen carbonate, and one or more of these are used. Among these, hydrogen carbonate is preferably used, and sodium hydrogen carbonate is more preferable in that a moderate foaming power can be realized.

  The solid acidic substance and the solid carbon dioxide generating substance may be a single powder or granular substance, or a powder or granule comprising a mixture with other components such as excipients and granulating agents. It may be.

  Examples of other components that can be contained in the powder or granule are, for example, powders such as lactose, powdered sugar, starch, dextrin, xylitol, D-sorbitol, glucose, D-mannitol, fructose, sucrose, sucrose, urea, etc. It can be used alone or in combination of two or more.

  Here, by obtaining a granule of the acidic substance and / or the carbon dioxide generating substance and other components to obtain granules of the solid acidic substance and / or the solid carbon dioxide generating substance, Although there is no restriction | limiting in particular as content of another component, It is preferable to set it as less than 80 mass% in the said granule. When other components are present in a content exceeding 80% by mass, foaming properties are lowered, which is not preferable.

  The method for producing the powder or granule is not limited to this example, and includes dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high-speed stirring granulation method, extrusion granulation method and the like. It can be produced according to a conventional method.

  For example, when a low melting point compound is used as a granulating agent as a matrix base, the acidic substance and / or the carbon dioxide generating substance is added to the low melting point granulating agent melted by heating in a container such as a beaker. Stir and mix thoroughly. You may add an appropriate additive to this as needed. The mixture is further stirred while being cooled at room temperature, and left to solidify. Once it has solidified to some extent, it may be rapidly cooled in a refrigerator or the like.

  Further, for example, the above materials may be put into a fluidized bed granulator, mixed by airflow for several minutes, and then granulated by spraying water.

  When a low melting point compound is not used for the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker to generate the acidic substance and / or the carbon dioxide gas. The substance is dissolved or dispersed and sufficiently mixed, and then heated in an oven or the like to remove the solvent and dried. When it is completely hardened, it is pulverized and sieved to make the size of the granules, and then granulated.

  As the shape of the solid acidic substance or solid carbon dioxide generating substance, for example, irregular shape, planar shape, polyhedron shape, spherical shape, drop shape, fibrous shape, cylindrical shape, fine powder shape, etc. are particularly limited. Can be adopted without any problem. Moreover, the thing of the wide range can be used without a restriction | limiting especially as the particle size. In particular, those having a particle size distribution of about 1,000 μm are more preferable from the viewpoint of ease of handling and ease of mixing with the viscous composition. The particle size distribution in the present invention can be determined by a normal laser diffraction / scattering method.

<Thickener>
The thickener used in the present invention is not particularly limited as long as it is a water-soluble component that can be used in the cosmetics and pharmaceutical fields. Polyvinyl alcohol, hydroxyethyl cellulose, hydroxypropyl methylcellulose, sulfonated cellulose derivatives, Hydrophilic synthetic polymers such as acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, cationized cellulose, pluronic, starch, xanthan gum, sodium alginate, sac In addition to hydrophilic natural polymers such as sinoglycan, carrageenan, guar gum, locust bean gum and celluloses, chondroitin sulfate, casein, co- Gen, gelatin, albumin, fibroin, elastin, keratin, hydrophilic protein compounds such as sericin, laponite, bentonite, hydrophilic thickening compound such as a hydrophilic clay mineral smectite, and the like.

  Among the above thickeners, the use of one having high solubility in water makes it possible to uniformly dissolve the one-part skin external preparation of the present invention without causing lumps, and the skin caused by undissolved components This is preferable because the rough feeling can be reduced. Here, the solubility in water is determined so that when the water is added at about room temperature and stirred, the skin external preparation instantly dissolves in water and dissolves uniformly so that carbon dioxide gas is retained. It can be determined from the fact that it has, or does not cause lumps during dissolution.

  Examples of such thickeners include starch, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, mannan, hyaluronic acid, curdlan, casein, collagen, gelatin , Albumin, fibroin, elastin, keratin, sericin, alginate, carboxyvinyl polymer, polyvinyl alcohol, sodium polyacrylate, acrylic acid / alkyl methacrylate copolymer, and the like.

  A thickener can be used by selecting 1 type from among the above, or using 2 or more types together, but it is preferable to use 2 or more types in combination. In particular, it is preferable to contain a hydrophilic protein compound as an essential component of the thickener. In the present invention, the hydrophilic protein compound refers to a protein compound that is soluble in a water-containing liquid. In the present invention, not only a single raw material but also a hydrolyzate thereof, a natural product containing these, The extract can also be used. The hydrophilic protein compound also has a role as a foaming aid, and in particular has a function of increasing the strength of bubbles and keeping the foam stable for a long period of time. Therefore, using hydrophilic protein compounds as essential thickeners alone or in combination with other thickeners improves the ease of adjusting the viscosity and solubility in water of topical skin preparations. Furthermore, skin conditioning effects, in particular, smooth skin, moist skin, moist skin, and soft skin can be provided. Among the hydrophilic protein compounds, casein, collagen, gelatin, albumin, fibroin, elastin, keratin, and sericin are preferable, and collagen, gelatin, albumin, and fibroin are particularly preferable, and albumin and collagen are most preferable.

  The thickener used in the present invention may be appropriately set according to the mixing ratio with the liquid containing water, but is preferably contained at 10 to 50% by mass in the whole skin external preparation, More preferably, it is 45 mass%. When the content is small, a feeling of roughness is likely to occur due to undissolved components when the skin preparation for external use and a liquid containing water are mixed. Moreover, since it is liable to sag and lacks adhesion, a sufficient blood circulation promoting action cannot be obtained. On the other hand, if the content of the thickener exceeds the above range, the solubility in water is inferior, causing lumps, causing discomfort when applied to the skin, and sufficient blood circulation promoting action cannot be obtained.

  Among the thickeners, the content of the hydrophilic protein compound is preferably 0.5 to 45% by mass, more preferably 1 to 30% by mass in the whole skin external preparation. It is particularly preferable that the content is 1 to 10% by mass.

  In the above thickener, the other thickener used in combination with the hydrophilic protein compound can be arbitrarily selected from the above thickeners and can be used, but at least one kind selected from the hydrophilic synthetic polymer or the hydrophilic natural polymer. It is preferable to use the above. Examples of hydrophilic synthetic polymers or hydrophilic natural polymers include polyvinyl alcohol, hydroxyethylcellulose, hydroxypropylmethylcellulose, sulfonated cellulose derivatives, acrylates / alkyl acrylate crosspolymers, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide. Copolymers, carboxymethylcellulose, cationized cellulose, pluronic, starch, xanthan gum, sodium alginate, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses and the like. In the above thickener, the blending amount of the other thickener may be set as appropriate, but it is preferably 1% by mass or more, more preferably 5% by mass or more, in the whole skin external preparation. It is particularly preferable that the content is 7% by mass or more.

  In the technical field of cosmetics (packs, etc.), increasing the amount of thickener is said to cause problems such as elongation, a decrease in solubility, and generation of residue, and the thickener is used at less than 1% by mass. It was common in this field. For this reason, even in the conventional carbonic acid pack, the amount used was limited to about 2 to 3% by mass. On the other hand, in the present invention, contrary to the previous knowledge possessed by those skilled in the art, by adding a lot of thickeners to the one-part skin external preparation, the rough feeling when applied to the skin unexpectedly is obtained. In addition, it is difficult to collapse the bubbles due to the generation of carbon dioxide, the amount of carbon dioxide retained is increased, and no dripping occurs when applied to the skin, and the effect of promoting the absorption of active ingredients can be obtained continuously. It was possible.

<Other ingredients>
The one-part skin external preparation of the present invention comprises, in addition to the solid acidic substance, the solid carbon dioxide generating substance and the thickener, other active ingredients, pH adjusting agents, fats and oils, depending on the application and purpose. , Colorants, antioxidants, fungicides, fungicides, alcohols, polyhydric alcohols, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, inorganic salts, lubricants, solvents, etc. It can be mixed with at least one of the components usually used in external preparations for skin.

  Hereinafter, representative components other than the solid acidic substance, the solid carbon dioxide generating substance and the thickener contained in the external preparation for skin of the present invention will be further described.

  The active ingredient used in the present invention is not particularly limited, and drugs, plants, and the like that are usually used in cosmetics, external medicines, quasi drugs, and the like can be used according to the purpose. Typical examples include glycyrrhizic acid or derivatives thereof, whitening agents such as placenta extract, moisturizing ingredients such as propylene glycol, polyethylene glycol, sorbitol, sodium lactate, sodium pyrrolidonecarboxylate, and plant ingredients such as licorice. It is done. As plant components, the whole plant, leaves (leaf blades, petiole, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots, tuberous roots, etc., are used as they are. It can be used by cutting, crushing, crushing, squeezing, extracting, or using these processed or dried powder. The extract may contain water as an extraction solvent, but the amount necessary for the generation of carbon dioxide by reacting the acidic substance and carbon dioxide generating substance during storage of the one-part skin external preparation of the present invention. Therefore, an extraction solvent containing moisture can be used.

<Usage form of external preparation for skin>
The one-part skin external preparation of the present invention does not substantially contain moisture in the preparation, and in use, foaming is caused by mixing with a liquid containing moisture on the palm or in a container.

  As the liquid containing water used in the present invention, any liquid can be used without particular limitation as long as it is a liquid containing water in addition to water used in cosmetics, pharmaceuticals, etc., water used in general households. Can do. For example, tap water, distilled water, membrane filtered water, ion exchange water, deep ocean water, sake, wine such as sake, soy milk, drink yogurt, acerola juice, sports drink, carbonated water drink, rice tofu, etc. Is mentioned. These may be used alone or in combination of two or more.

  The amount of water-containing liquid used is not particularly limited and can be used in a wide range, but it is preferably added in an amount of 1 to 10 times by weight with respect to the external preparation for skin, and 2 to 5 times. It is more preferable to add the amount. By adding more than 1 times the amount of liquid, the external preparation for skin can be quickly dissolved, and a sufficient amount of carbon dioxide gas can be generated. On the other hand, dripping due to a decrease in viscosity of the external preparation for skin can be prevented by adding the liquid within 10 times the amount.

  The temperature of the liquid containing the moisture to be used is not particularly limited and can be used in a wide range. However, since the action of the active ingredient of the one-part skin external preparation is enhanced, it is particularly useful to cool in advance. preferable. The usable temperature range is preferably water at about room temperature or tap water from the viewpoint of usability during application and user convenience.

  The method for preserving the external preparation for skin is not particularly limited as long as it is stored in a state where it blocks moisture and does not come into contact. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples thereof include cup shape, tube shape, bag shape, bottle shape, stick shape, pump shape, jar shape, and canned shape. Moreover, the material which comprises a storage container can use plastics, glass, aluminum, paper, various polymers, etc. individually or in combination of 2 or more types, but is not limited to these.

  Specific examples of containers include: aluminum sticks laminated with polyethylene terephthalate on the inner surface, storage bags such as aluminum bags, stand pouch with chuck, polyethylene terephthalate on the inner surface in terms of hermeticity, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate in which the lid is heat-sealed with an aluminum film or the like laminated with is preferable.

<Uses of external preparations for skin>
The topical skin preparation of the present invention promotes an increase in skin blood flow and a skin conditioning effect, whitening, improvement of skin quality, improvement of freckles, skin rejuvenation, skin tightening, partial thinning, clean the skin, Prepares the skin, smoothes the skin, keeps the skin healthy, prevents rough skin, tightens the skin, moisturizes the skin, keeps skin moisture and oil, keeps the skin soft, protects the skin Not only cosmetics intended to prevent skin dryness, soften skin, give skin elasticity, give skin gloss, smooth skin, sunburn spots and freckles, but also skin That, that, nature, prevention of rashes, mists, cracks, redheads, acne, oily skin, prevention of razor rashes, prevention of spots and freckles caused by sunburn, prevention of hot flashes after sunburn, snow and burns, squeezing the skin, Suitable for both quasi-drugs and drugs such as pharmaceuticals for the purpose of cleansing, conditioning the skin, keeping the skin healthy, moisturizing the skin, protecting the skin, preventing the skin from drying out, etc. Can be used. It is preferable to use it as cosmetics or quasi-drugs such as emulsions, creams, packs, and peeling agents, and more preferably as packs.

  Prior to obtaining the optimum thickener amount range, Reference Example 1 shown in Table 1 below was first prepared, and the state of foam was confirmed. Various thickeners and other components were added to this, and the state of foaming was observed. When albumin was selected as the hydrophilic protein compound, as described in Table 1 as Reference Example 2, a phenomenon in which the strength of the bubbles was particularly increased and the bubbles were not easily crushed was observed. Even when other thickeners that are not albumin are added, the evaluation results of solubility, sagging, and the amount of carbon dioxide that can be retained other than the strength of the bubbles are considered not to be significantly different from the case of adding albumin.

  EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated further more concretely, the scope of the present invention is not limited to these Examples.

<Examples 1-5, Comparative Examples 1-4>
According to the composition shown in Table 2, the one-part skin external preparations of Examples 1 to 5 containing 12, 15, 20, 25, 45% by weight of the thickener, and 5, 6, 10, One-part skin external preparations of Comparative Examples 1 to 4 containing 55% by mass were produced.

According to the following procedure, the properties of the one-part skin external preparations of the above Examples and Comparative Examples were evaluated.
<Roughness evaluation>
A powdery one-part skin external preparation sample and water are mixed at 1: 3 (weight ratio) in a container, and the feel is evaluated based on the following criteria.
○ No rough or uncomfortable feeling during application or use.
△ Although slightly rough at the time of application, there is no discomfort during use.
× There is a feeling of roughness and discomfort during application and use.

<Evaluation of solubility>
A powdery one-part skin external preparation sample and water are mixed in a container at a ratio of 1: 3 (weight ratio), visually observed during stirring, and evaluated based on the following criteria.
○ Immediately after mixing, the powder dissolves uniformly and does not cause lumps.
Δ Immediately after mixing, the powder absorbs water and gels, producing some lumps.
X Immediately after mixing, the powder absorbs water and gels, resulting in a lumpy shape.

<Evaluation of sagging>
The powdered one-part skin external preparation sample and water were mixed in a container at a ratio of 1: 3 (weight ratio), and the mixture was applied to a person's arm standing vertically to prevent the mixture from dripping. Observe and evaluate based on the following criteria.
○ After application, no dripping occurs even after a certain period of time, and the mixture stays on the skin.
△ One minute after application, dripping occurs and a part of the mixture does not stay on the skin.
× Dripping immediately after application, hardly stays on the skin.

<Evaluation of the amount of carbon dioxide foaming of a one-part skin external preparation>
21 g of water was weighed in a 225 mL bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, and 7 g of a powdery one-part skin external preparation sample was added thereto and stirred 20 times for 10 seconds. Before stirring, immediately after stirring, after 1 minute, after 10 minutes, and after 20 minutes, the volume was measured, and the increase rate of the volume with respect to the volume before stirring was measured. The result is shown in FIG. Moreover, the volume increase rate of the carbon dioxide gas after 20 minutes was made into the carbon dioxide amount which can be hold | maintained.

  In Table 3, each evaluation result of said roughness, solubility, sagging, and the amount of carbonic acid which can be hold | maintained, and the comprehensive evaluation result of the one agent type skin external preparation which can be judged from these results are shown.

  The external preparation for skin of Comparative Example 1 containing 5% of the thickener and Comparative Example 2 containing 6% had a rough feeling, dripping occurred, and the amount of carbon dioxide gas that could be retained in the mixture was remarkably small. Moreover, even if it was the skin external preparation of the comparative example 3 which contains 10% of thickeners, dripping occurred. On the other hand, the external preparation for skin of Comparative Example 4 containing 55% of a thickener was remarkably inferior in solubility, generation of gelation and lumps was observed, and the amount of carbon dioxide gas that could be retained in the mixture was not very large. The amount of carbon dioxide gas that can be held in the mixture was excellent in the order of Example 4> Example 2, 3≈Comparative Example 3> Example 5≈Comparative Example 4> Comparative Examples 1 and 2 as seen from FIG. When the above results are comprehensively evaluated, the skin external preparations of Examples 1 to 4 which are embodiments of the present invention containing 12 to 45% by mass of the thickener are superior as the skin external preparations compared to the comparative examples. I understood that.

  As is clear from the above examination, the skin external preparation of the present invention contains a thickener in a higher composition than conventional external preparations, in addition to improving the retention of carbon dioxide gas and the dripping property, it is rough. It has the effect of preventing feeling.

<Examples 6-7, Comparative Examples 5-7>
According to the composition shown in Table 4, a one-part skin external preparation was produced.

About the obtained one-part skin external preparation, the amount of carbon dioxide foam (volume increase rate, the amount of carbon dioxide that can be retained), skin conditioning effect (smooth skin, moist skin, moist skin, soft skin) The stratum corneum moisture content was evaluated. In the evaluation, the one-part skin external preparation prepared according to the composition of Table 4 and water were mixed in a container at a ratio of 1: 3 (weight ratio).

<Evaluation of the amount of carbon dioxide foaming of a one-part skin external preparation>
30 g of water was weighed into a 225 mL bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, and 10 g of a powdery one-part skin external preparation sample was added thereto and stirred 20 times for 10 seconds. Before stirring, immediately after stirring, after 1 minute, after 10 minutes, and after 20 minutes, the volume was measured, and the increase rate of the volume with respect to the volume before stirring was measured. The result is shown in FIG. Moreover, the volume increase rate of the carbon dioxide gas 20 minutes after was made into the holdable carbonic acid amount.

<Evaluation of skin conditioning effect>
Five females in their 20s and 30s were subjects, and the evaluation was conducted through a questionnaire. Evaluation was performed as follows. The inner side of the subject's forearm was washed with face wash and rested in the measurement room for 15 minutes. Subsequently, a one-part skin external preparation mixed with water was applied for 10 minutes in the range of 4 cm × 4 cm inside the forearm and allowed to stand. Subsequently, after 10 minutes, the applied one-part skin external preparation was removed and washed with water. Thereafter, a questionnaire was conducted on four items: smooth skin, moist skin, moist skin, and soft skin. For each item, the comparative example 7 was used as a standard, and a score was assigned to 7 levels shown in Table 5 as (4 points), and an average value of 5 people was obtained.

<Evaluation of moisture content in stratum corneum>
The stratum corneum water content was evaluated by measuring the water content of the stratum corneum before and after the use of the one-part skin external preparation, with 5 females in their 20s to 30s as subjects. Evaluation was performed as follows. The inner side of the subject's forearm was washed with face wash and rested in the measurement room for 15 minutes. Thereafter, the water content of the stratum corneum in the range of 4 cm × 4 cm on the inner side of the forearm was measured with a skin surface stratum corneum water content measuring device (manufactured by IBS Co., Ltd .: SKICON-200EX). The previous measured value was used. The skin surface stratum corneum water content measuring apparatus is an apparatus for evaluating the water content of the stratum corneum by electrical conductivity. Subsequently, a one-part skin external preparation mixed with water was applied to the inside of the forearm in a range of 4 cm × 4 cm inside the forearm for 10 minutes and allowed to stand. Subsequently, after 10 minutes, the applied one-part skin external preparation was removed and washed with water. After 15 minutes from the washing, the amount of water in the stratum corneum after using the one-pack type skin external preparation was measured. In the obtained results, the value before use of the one-pack type external preparation for skin was set to 1, and the change rate after use was calculated.

The results obtained for Examples 6 to 7 and Comparative Examples 5 to 7 are shown in FIG. 2, Table 6, and FIG.

From FIG. 2, Examples 6 and 7 using a hydrophilic protein compound and other thickeners as the thickener have a higher volume increase rate than other one-part skin external preparations, and the foam is kept for 20 minutes. It was confirmed that it could be retained later. On the other hand, in Comparative Examples 5 to 7 having a single thickener, the volume increase rate after 10 minutes and after 20 minutes is equal to or smaller than that after 1 minute. I can't hold it.
Also, from Table 6, Examples 6 and 7 are any of smoothness of skin, moist feeling of skin, moist feeling of skin, and softness of skin as compared with one-part skin external preparation of Comparative Example 7. The item was found to be excellent. On the other hand, Comparative Examples 5 and 6 containing only one kind as a thickener were comparable to Comparative Example 7 in both evaluation results.
In addition, as a result of measuring the stratum corneum moisture content from FIG. 3, in Examples 6 and 7, the stratum corneum moisture content is significantly increased, and the one-part skin external preparations of Comparative Examples 5 to 7 are all It was found that the increase in stratum corneum moisture before and after use was small.

  Based on the above results, the one-part skin external preparation of the present invention after correction has a strong foam strength by using a hydrophilic protein compound and other thickeners in combination as a thickener. It was found to be stable for a long time and to have a significant skin conditioning effect.

[Prescription example of one-part skin external preparation]
The specific formulation example of the one-part skin external preparation of this invention is shown below further.
<Example 8>
Each component was mix | blended with the compounding ratio of Table 7, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 9>
Each component was mix | blended with the mixture ratio of Table 8, and it was set as the powdery one-pack type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 10>
Each component was mix | blended with the mixture ratio of Table 9, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was placed in a container and 1 weight of water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 11>
Each component was mix | blended with the compounding ratio of Table 10, and it was set as the powdery one-part skin external preparation. When this one-part type skin external preparation powder was placed in a container and 10 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 12>
Each component was mix | blended with the mixture ratio of Table 11, and it was set as the powdery one-part skin external preparation. When this one-part type skin external preparation powder was put in a container and 5 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 13>
Each component was mix | blended with the mixture ratio of Table 12, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 14>
Each component was mix | blended with the mixture ratio of Table 13, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 15>
Each component was mix | blended with the mixture ratio of Table 14, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 16>
Each component was mix | blended with the mixture ratio of Table 15, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was placed in a container and 1 weight of water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 17>
Each component was mix | blended with the compounding ratio of Table 16, and it was set as the powdery one-part skin external preparation. When this one-part type skin external preparation powder was placed in a container and 10 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 18>
Each component was mix | blended with the mixture ratio of Table 17, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container and 5 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 19>
Each component was mix | blended with the mixture ratio of Table 18, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

  All of the one-part skin external preparations according to the above formulations showed good solubility in water, and each produced fine bubbles due to the generation of carbon dioxide. When the foam-like pack cosmetic obtained from the one-pack type external preparation for each formulation was applied to the face, there was no dripping or the like for several minutes, and the blood circulation promoting action was continuously obtained. In particular, even in the formulations of Examples 9 and 17 in which 10 times the amount of water was added to the one-pack type external skin preparation, no dripping or the like was observed, and it was confirmed that it functions well as a pack.

Claims (1)

A one-part skin external preparation containing at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener, wherein the thickener is A hydrophilic protein compound and other thickeners are used in combination, and the hydrophilic protein compound is at least one selected from collagen, fibroin, elastin, keratin, and sericin, and the thickener is used in the whole skin external preparation. 10 to 50% by mass, and the other thickening agent is 7% by mass or more in the whole skin external preparation, and is a one-part skin external preparation that is mixed with a water-containing liquid when the skin external preparation is used.