JP5818334B2 - Toothpaste composition - Google Patents

Description

  The present invention relates to a dentifrice composition containing erythritol.

  The purpose of brushing teeth is to clean the oral cavity and provide a refreshing feeling. As means for improving the refreshing feeling, conventionally, a fragrance component typified by menthol and a solvent component such as ethanol have been added. However, when these components are added in an increased amount, irritation in the oral cavity becomes stronger and foaming is suppressed, resulting in a problem of impairing the feeling of use when polished. Therefore, recently, specific sugar alcohols such as erythritol and xylitol have been used from the viewpoint of both effects of cleanliness of the oral cavity and a refreshing feeling (for example, Patent Documents 1 and 2). In particular, certain sugar alcohols prevent bacterial adhesion and aggregation in the process of plaque formation and oral biofilm formation, make it easier to remove oral biofilm after formation, and prevent oral diseases such as caries. It is known to be effective (for example, Patent Documents 3 and 4).

However, from the viewpoint of solubility, sugar alcohol may cause crystals to precipitate depending on the type and content of combination. In particular, when a sugar alcohol with low solubility such as erythritol is blended in a granular or powder form at a high concentration, dissolution and recrystallization are repeated due to temperature change, resulting in a large crystal or a change in crystal form (crystal habit). )there is a possibility. Furthermore, if the amount of added water is small with respect to high-concentration sugar alcohol, crystal precipitation is suppressed, but the binder does not dissolve and water and other liquid components are easily separated, which impairs storage stability. Problems arise.
On the other hand, Patent Document 5 proposes a dentifrice composition that suppresses crystal growth of erythritol and stably blends it by blending maltitol or glycerin with a high concentration of sugar alcohol, particularly erythritol. .

JP 2000-191383 A JP-A-2005-281306 JP 2005-8579 A JP 2005-29484 A JP 2009-23953 A

The toothpaste composition contains medicinal ingredients for enhancing the preventive effect against tooth decay, bad breath, and gingivitis, and various active ingredients for whitening teeth. Lowering the viscosity of the toothpaste composition increases the diffusibility of the toothpaste composition in the mouth, allowing the medicinal and active ingredients contained in the composition to spread into the mouth before the composition is diluted into saliva. However, the present inventors have discovered that when the viscosity of the toothpaste composition is lowered, the recrystallized sugar alcohol crystals tend to aggregate. The recrystallized sugar alcohol agglomerates may cause a rough feeling of use, or the agglomerates may accumulate in the mouth portion of the tube container containing the toothpaste composition, resulting in a decrease in discharge performance or blockage. .
Therefore, an object of the present invention is to provide a toothpaste composition having a high refreshing feeling, a low viscosity, excellent in the mouth diffusibility of the toothpaste composition, and excellent in the aggregation suppressing effect of powdered or granular erythritol. It is in.

  The inventor has a high concentration of erythritol, has a high refreshing feeling, and even in a low-viscosity toothpaste composition, by blending a certain amount of silica with a specific oil absorption amount, the effect of suppressing erythritol aggregation is obtained. It has been found that an excellent toothpaste composition with good usability can be obtained.

That is, the present invention provides a toothpaste composition containing the following components (A) to (C) and having a viscosity at 25 ° C. of 30 to 250 Pa · s.
(A) Erythritol having an average particle diameter of 200 μm or less 25 to 55% by mass
(B) Water 15-35 mass%
(C) Silica having an oil absorption of 200 to 400 mL / 100 g 0.5 to 10% by mass

  The toothpaste composition of the present invention has a high refreshing feeling, low viscosity, excellent diffusibility in the mouth, and excellent anti-aggregation effect of powdered or granular erythritol.

  The toothpaste composition of the present invention contains erythritol (component (A)) having an average particle size of 200 μm or less. The particle diameter of erythritol is 200 μm or less from the viewpoint of obtaining a good refreshing feeling and cool feeling, but from the viewpoint that the cooling feeling is maintained in the mouth, the average particle diameter is preferably 30 to 200 μm, Furthermore, 30-150 micrometers is preferable, and 30-100 micrometers is especially preferable.

The erythritol particle size is measured as follows.
Sieve: JIS standard sieve φ75mm
Opening: From the upper stage, a receiver is provided under a sieve having openings of 500 μm, 355 μm, 250 μm, 180 μm, 125 μm, 90 μm and 45 μm, respectively. Shaker: Micro type electromagnetic vibrator M-2 type (Tsutsui Rikenki Co., Ltd.) Method: Place 15 g of sample on a 500 μm sieve, and classify with an electromagnetic vibrator for 5 minutes. The sieving rate (cumulative amount) is plotted on regular established paper, and the value corresponding to 50% is taken as the average particle diameter. Such a particle diameter can be adjusted by pulverizing crystalline erythritol. For pulverization of erythritol, a roller mill, a hammer mill, a high-speed pulverizer, a pulverizer, or the like can be used. As crystalline erythritol, commercially available products such as Nikken Kasei Co., Ltd., Mitsubishi Chemical Foods Co., Ltd., Cargill Co., etc. are available.

  The erythritol content with an average particle size of 200 μm or less in the toothpaste composition of the present invention is 25 to 55% by mass, preferably 30 to 55% by mass, more preferably from the viewpoint of obtaining storage stability and a higher refreshing feeling. It is 35-50 mass%. When the erythritol content is less than 25% by mass, a sufficient refreshing sensation cannot be obtained. . Moreover, 30-60 mass% is preferable, as for the compounding quantity of the erythritol with an average particle diameter of 200 micrometers or less to a toothpaste composition, 35-60 mass% is more preferable, and 35-55 mass% is especially preferable. Considering the cost of the composition, the amount of erythritol to be blended in the composition is preferably 60% by mass or less.

  The toothpaste composition of the present invention contains 15 to 35% by mass of water (component (B)), and preferably 15 to 30% by mass, particularly preferably 17 from the viewpoint of obtaining storage stability and a higher refreshing feeling. Contains -25% by mass.

  From the viewpoint of suppressing aggregation of erythritol, (C) silica used in the present invention has an oil absorption of 200 to 400 mL / 100 g and is generally referred to as thickening silica. (C) The oil absorption of silica is more preferably 220 to 380 mL / 100 g, and still more preferably 250 to 350 mL / 100 g. Here, the amount of oil absorption indicates the amount of oil that can be supported by silica, and the measuring method is specified by the amount of oil to be absorbed in the boiled sesame by a method according to JIS K5101-13-2. Such silica is available from Silicia, Silopure (Fuji Silysia Chemical), Thixosyl (Rhodia), Sorbosil (Ineos Silica), Fine Seal (Tokuyama), Nipgel (Tosoh Silica) It is. Note that silica having a large amount of oil absorption used here is different from silica used as an abrasive. Generally, the oil absorption of silica used as an abrasive is 50 to 150 mL / 100 g.

  The content of (C) silica in the toothpaste composition of the present invention is 0 from the balance between the effect of suppressing erythritol aggregation and the effect of improving the oral diffusivity of active ingredients such as medicinal ingredients and phytic acid by keeping the viscosity low. It is 5-10 mass%, More preferably, it is 1.5-10 mass%, Most preferably, it is 2-8 mass%. Further, the mass ratio (C / B) of the content of (C) silica and the content of (B) water in the toothpaste composition is the effect of suppressing the aggregation of erythritol and the dispersion in the mouth of medicinal ingredients by keeping the viscosity low. From the balance with the property improvement effect, it is preferably 0.05 to 0.4, more preferably 0.1 to 0.35, and particularly preferably 0.15 to 0.3.

    The toothpaste composition of the present invention further contains (D) a binder. (D) The binder does not contain (C) silica of the present invention, and includes binders other than component (C) silica, which can be used in a dentifrice composition, specifically alginic acid. Sodium, sodium carboxymethylcellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, caraya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, chondroitin 1 type (s) or 2 or more types chosen from the group which consists of sodium sulfate, a methoxyethylene maleic anhydride copolymer, etc. can be included. Of these, sodium carboxymethylcellulose, carrageenan, xanthan gum and sodium polyacrylate are preferred. In particular, it is preferable to use two or more, more preferably three or more, in terms of shape retention, stringiness, and usability.

    The content of the binder (D) in the toothpaste composition of the present invention varies depending on the content of water, the type of binder, etc., but the viscosity at 25 ° C. of the toothpaste composition is 30 to 250 Pa · s. In view of this, when (D) the binder is one or more selected from sodium carboxymethylcellulose, carrageenan, xanthan gum and sodium polyacrylate, the total content of (D) binder is 0. .3-1.0 mass% is preferable, 0.4-0.9 mass% is further preferable, and 0.4-0.7 mass% is especially preferable. The total content of the component (C) and the component (D) is preferably 1.0 to 10% by mass, more preferably 3.5 to 10% by mass, further preferably 3.5 to 8% by mass, and particularly 5 -8 mass% is preferable. Further, the mass ratio (C: D) of the content of the component (C) and the component (D) is preferably 20: 1 to 2: 1, more preferably 15: 1 to 3: 1, and particularly 12: 1 to 1. 5: 1 is preferred.

  The viscosity of the toothpaste composition of the present invention is 30 to 250 Pa from the viewpoint of improving the diffusibility in the mouth of medicinal components and the like, and improving the uptake of the medicinal components and the like into the teeth and gums and preventing dripping from the toothbrush. S, preferably from 30 to 200 Pa · s, more preferably from 50 to 180 Pa · s, from the viewpoint of the erythritol aggregation inhibiting effect. Here, the viscosity can be measured using a helipath type viscometer at a measurement temperature of 25 ° C. and measurement conditions of rotor C, 2.5 r / min, and 1 minute.

The toothpaste composition of the present invention preferably further contains 0.01 to 2% by mass of a medicinal component. Examples of the medicinal component include a fluoride ion supply compound, a bactericidal agent, an anti-inflammatory agent, an antiplasmin agent, an anticalculus agent, a blood circulation promoter, an anti-hypersensitivity agent, an enzyme, and a cigarette removal agent. Among these, from the viewpoint of dispersibility in the mouth of the toothpaste composition of the present invention, a fluorine ion supply compound, a bactericidal agent, and an anti-inflammatory agent, which are medicinal components that are preferably mixed in a small amount, are preferable. Fluorine ion supply compounds include sodium fluoride, potassium fluoride, ammonium fluoride, lithium fluoride, monofluorophosphate (eg, sodium monofluorophosphate, potassium monofluorophosphate, ammonium monofluorophosphate, etc.) Organic fluorides such as inorganic fluorides and amine fluorides may be mentioned, among which sodium fluoride, sodium monofluorophosphate and tin fluoride are preferable. Bactericides include chlorhexidine salts, quaternary ammonium compounds such as cetylpyridinium chloride, benzethonium chloride, isopropylmethylphenol, triclosan, trichlorocarbanilide, among which cetylpyridinium chloride, isopropylpyromethylphenol, triclosan are preferable. Anti-inflammatory agents include allantoin, allantoinchlorohydroxyaluminum, azulene, glycyrrhetinic acid, epidihydrocholesterin, hinokitiol, lysozyme chloride, glycyrrhizic acid and salts thereof, among which allantoin, allantoinhydroxyhydroxyaluminum, glycyrrhetic acid, glycyrrhizin Dipotassium acid is preferred. Examples of antiplasmin agents include tranexamic acid and epsilon aminocaproic acid. Examples of the anticalculus agent include zeolite, phosphoric acid and salts thereof, pyrophosphoric acid and salts thereof, polyphosphoric acid and salts thereof, and among them, zeolite, sodium pyrophosphate and sodium polyphosphate are preferable. Examples of the blood circulation promoter include dl-α-tocopherol acetate and dl-α-tocopherol nicotinate. Examples of the anti-sensitivity agent include potassium nitrate and aluminum lactate. Examples of the enzyme include dextranase, mutanase, and amylase. Examples of the tobacco remover include polyethylene glycol and polyvinylpyrrolidone.
The toothpaste composition of the present invention preferably has a low content of medicinal components, and preferably has a medicinal component content of 0.01 if the mouth diffusibility is good from the point of regulation of taste and blending amount. It is -1.5 mass%, More preferably, it is 0.01-1.0 mass%.

  The toothpaste composition of the present invention can further contain phytic acid or a salt thereof. By blending phytic acid or its salt, it removes minute dirt on the tooth surface without damaging the tooth enamel and gives natural luster, and the trabecular space on the surface of the tooth enamel Can be removed selectively, increasing light scattering by the space between the trabeculae, and obtaining natural white teeth. In addition, since the dentifrice composition of the present invention has good diffusibility in the mouth of phytic acid or a salt thereof, it is possible to sufficiently obtain the effects of imparting gloss and increasing reflected light due to light scattering. In addition, the content of phytic acid is preferably from 0.1 to 5% by mass, more preferably from 0.15 to 3% by mass, particularly from 0.2 to 2 in terms of imparting taste and gloss and increasing the reflected light due to light scattering. Mass% is preferred.

  The pH of the toothpaste composition of the present invention is preferably 5 to 7.5 from the viewpoint of taste, and when it contains phytic acid or a salt thereof, 5 to 7 from the viewpoint of increasing the reflected light due to glossiness and light scattering. Preferably, 5.5-7, especially 5.5-6.5 are preferred. Here, the pH of the toothpaste composition of the present invention can be measured using a pH electrode after adjusting to a 30% by mass aqueous solution by adding distilled water.

  The toothpaste composition of the present invention has (A) glycerin and / or maltitol (hereinafter referred to as “glycerin and the like”) from the viewpoint of suppressing large growth of crystals when erythritol is dissolved and recrystallized by temperature change. It is preferable to contain. The content of glycerin and the like is preferably 0.25 to 0.8 in terms of mass ratio (glycerin and the like / A) to component (A) erythritol from the viewpoint of viscosity and taste, and further 0.3 to 0 .8, and particularly preferably 0.4 to 0.8.

  In addition to the above components, the toothpaste composition of the present invention may appropriately contain, for example, a foaming agent, a foaming aid, an abrasive, a sweetener, a fragrance, a pH adjuster, a preservative, a pigment, a dye, and the like.

  As abrasives, silica-based abrasives such as hydrous silica, anhydrous silica, silica gel, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate and anhydrous, calcium pyrophosphate, calcium carbonate, alumina, aluminum hydroxide Magnesium acetate, tribasic magnesium phosphate, zeolite, and synthetic resin abrasives are preferably used. The content of the abrasive is preferably 1 to 20% by mass. In addition, the oil absorption amount of the said silica type abrasive | polishing agent is 50-150 mL / 100g, Preferably it is 75-125 mL / 100g.

  Examples of the sweetening agent include saccharin sodium, aspartame, thaumatin, acesulfame potassium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perilartin.

  As a fragrance, 1-menthol, carvone, anethole, eugenol, limonene, peppermint oil, spearmint oil, ocimen, n-amyl alcohol, citronellol, α-terpineol, methyl salicylate, methyl acetate, citronole acetate, cineol, linalool, Examples include ethyl linalool, crocodile, thymol, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, perilla oil, clove oil, and eucalyptus oil.

  In the toothpaste composition of the present invention, it is desirable that erythritol is dispersed in the form of powder or granules from the viewpoint of obtaining a sufficient refreshing feeling. For this purpose, erythritol is preferably added in the final process of production in the form of powder or granules. By using such a production method, erythritol can be present in powder form or granular form in the dentifrice composition without being substantially dissolved in water. Specifically, for example, purified water, a wetting agent, a binder, a preservative, a sweetener and a medicinal ingredient are mixed according to certain production conditions, and (D) the binder is sufficiently swollen, (C) The toothpaste composition of the present invention can be produced by adding and mixing silica, an abrasive and a foaming agent, and a fragrance, and finally adding powdered or granular erythritol and defoaming and mixing.

The toothpaste compositions shown in Table 1 were prepared by the following procedure, filled into tubes, and evaluated for the crystalline state and feeling of use of erythritol, the dispersibility of the paste, and the viscosity. The results are shown in Table 1.
(Manufacturing procedure)
In the composition of Table 1, after mixing ingredients other than abrasive silica, sodium lauryl sulfate, fragrance, and erythritol in water to sufficiently swell the binder (C), (C) silica, abrasive silica, Sodium lauryl sulfate and a fragrance were added, and finally powdered and granular erythritol was added and defoamed and mixed to obtain a toothpaste composition.

[Evaluation of crystalline state and feeling of use of erythritol]
The toothpaste composition shown in Table 1 was packed in a storage tube and stored for 30 days in a cycle tester at 40 ° C / 12h and 5 ° C / 12h. Then, the tube was cut open, and the state of erythritol was evaluated according to the following criteria by visual observation and usability.
A: There is no change in appearance and feel compared to the one before storage.
○: There is a slightly rough feel compared to the one before storage.
(Triangle | delta): Although aggregation is not confirmed compared with the thing before a preservation | save, there exists a rough feeling.
X: Aggregation can be clearly confirmed as compared with that before storage.

[Evaluation of paste dispersibility]
1 g of the toothpaste composition shown in Table 1 was taken on a transparent glass slide, poured into warm water at 35 ° C., and the warm water was stirred at 200 rpm / min for 30 seconds. The state of toothpaste remaining on the slide glass after 30 seconds was visually evaluated according to the following criteria.
◎: No paste left ○: Paste remains slightly △: Paste remains a little ×: Paste remains more than half

(Viscosity measurement)
The toothpaste composition shown in Table 1 was packed in a container for viscosity measurement and stored for 24 hours in a thermostatic chamber at 25 ° C., and then the viscosity was measured under the conditions of rotor C, 2.5 rpm, and 1 minute using a helicopter viscometer. Was measured.

  As is apparent from Table 1, the toothpaste composition of the present invention contains silica having an oil absorption of 320 mL / 100 g, has an effect of suppressing aggregation of erythritol while being low in viscosity, and has excellent paste dispersibility. It was. On the other hand, the low-viscosity toothpaste composition of Comparative Example 1 in which silica having an oil absorption amount of 320 mL / 100 g was not blended was found to aggregate erythritol. In the toothpaste composition of Comparative Example 2, an effect of suppressing aggregation of erythritol was recognized, but a result with high viscosity and low dispersibility of the paste was obtained.

Claims (6)

The following components (A) to (E):
(A) 25-55 mass% erythritol whose average particle diameter is 200 micrometers or less,
(B) 15-35% by weight of water,
(C) Silica having an oil absorption of 200 to 400 mL / 100 g 1.5 to 10% by mass
(D) 0.7 mass% or less in total of binder (E) It contains glycerin and / or maltitol, and the mass ratio (C: D) of (C) silica and (D) binder is 20: 1. A toothpaste composition having a mass ratio of (C) silica and (B) water (C / B) of 0.1 to 0.3 .   The toothpaste composition according to claim 1, wherein component (E) is glycerin.   Furthermore, the toothpaste composition of Claim 1 or 2 which contains a medicinal component 0.01-2 mass%.   The dentifrice composition according to claim 3, wherein the medicinal component is one or more selected from a fluoride ion supplying compound, a bactericidal agent and an anti-inflammatory agent.   (D) The total content of a binder is 0.3-1.0 mass%, The toothbrushing composition of any one of Claims 1-4.   Furthermore, the toothbrushing composition of any one of Claims 1-5 containing sorbitol.