JP3480952B2 - External preparation for skin - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation having an excellent skin inflammation preventing effect and a whitening effect.

[0002]

2. Description of the Related Art Conventionally, agents having an anti-inflammatory effect such as calamine have been used to suppress skin inflammation due to sunburn, and whitening effects such as ascorbic acid and glutathione have been used to suppress pigmentation after sunburn. The medicines it has been used as a component of external preparations for skin.

[0003]

However, external preparations for skin containing these agents have weak anti-inflammatory effects and whitening effects, and have not been sufficiently satisfactory.

[0004]

In view of the above-mentioned circumstances, the inventors of the present invention have conducted diligent research and as a result, have found that an extract of squid, mocca or iclinin (hereinafter, also referred to as an extract of the family Rosaceae) By adding a substance having a specific anti-inflammatory effect, it is possible to obtain a skin external preparation which solves the above problems and synergistically improves the effects of suppressing skin inflammation due to sunburn and pigmentation after sunburn. Heading, completed the present invention.

That is, the present invention relates to (A ₁ ) mica squid extract, and (B ₁ ) (i) Scutellaria barba extract, or (b) guaiazulene, ε-aminocaproic acid, or one or two of these derivatives. Anti-inflammatory and whitening skin external preparation containing the above; (A ₂ ) Mokka extract and (B ₂ ) elderberry extract containing anti-inflammatory and whitening skin external preparation ; (a ₃₎ Ikurinin extract, and (B ₃₎ is intended to provide an anti-inflammatory and whitening skin external agent characterized by containing cattail extract.

The method of preparing the extract of the plant of the family Rosaceae of the component (A) of the present invention is not particularly limited, but it is extracted, for example, using various suitable solvents at room temperature to under heating. Examples of the extraction solvent include water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol; lower alkyl esters such as ethyl acetate; benzene and hexane. Hydrocarbons; one kind or two or more kinds of ethers such as diethyl ether can be used. Particularly, water, ethyl alcohol, glycerin, and a mixed solvent of one or more kinds of 1,3-butylene glycol are preferable. As the extraction conditions, a solvent is used in a volume ratio of 1 to 1000 times, particularly 5 to 100 times the volume of the Rosaceae plant,
It is preferable to carry out at a temperature of 4 ° C. or higher, particularly 15 to 30 ° C., for 1 hour or longer, particularly 1 to 3 days.

The Rosaceae plant extract obtained under the above conditions may be used as it is as an extracted solution, but if necessary, it may be subjected to treatments such as concentration and filtration. These may be used alone or in combination of two or more.

In the external preparation for skin of the present invention, the compounding amount of the component (A) is 0.0001 to 1 in terms of dry solid content.
0.0 wt% (hereinafter referred to simply as "%") is preferable,
Particularly, the range of 0.01 to 5.0% is preferable. If the content is less than 0.0001%, the effect is not sufficiently exerted and 1
Even if it exceeds 0.0%, the effect is not further increased.

The plant extract having an anti-inflammatory effect of the component (B) of the external preparation for skin of the present invention, which has anti-inflammatory action, is the same as that of Scutellaria barbata L., elder or cattail, and water, ethanol, propylene glycol, 1,3-. It is obtained by extracting with one or more solvents such as butylene glycol, or by drying this extract.

The blending amount of the plant extract component is preferably 0.0001 to 10%, and particularly preferably 0.01 to 5% as a dry weight in the total amount of the skin external preparation of the present invention.

[0011]

Examples of the component (B) (B) guaiazulene or its derivative include guaiazulene, guaiazulene sulfonic acid, salts thereof and esters thereof. Specific examples thereof include guaiazulene, ethyl guaiazulene sulfonate and sodium guaiazulene sulfonate. Is exemplified. The compounding amount is 0.001 to 8 in the total amount of the external preparation for skin.
%, Particularly 0.1-5% is preferable.

The content of ε-aminocaproic acid is preferably 0.001 to 8%, more preferably 0.1 to 5% of the total amount of the external preparation for skin.

Further, the external preparation for skin of the present invention contains, in addition to the above-mentioned essential components, aqueous components, powders, surfactants, oils, which are used in ordinary external preparations for skin, as long as the effects of the present invention are not impaired. Moisturizers, alcohols, pH adjusters, preservatives, pigments,
Antioxidants, ultraviolet absorbers, thickeners, fragrances, beauty ingredients and the like can be appropriately added as needed.

The external preparation for skin of the present invention can be produced by mixing the essential components (A) and (B) in a conventional manner. In addition to emulsions, creams, lotions, beauty essences, cleansing, packs, foundations, detergents, etc., it can be made into pharmaceuticals such as dispersions, ointments and granules, quasi-drugs or cosmetics.

[0016]

EXAMPLES The present invention will be described in more detail with reference to test examples and examples, but the present invention is not limited thereto.

The followings were used as the mica extract, mocca extract and iclinin extract. Maika squid extract: Heat-extracted with 30 v / v% ethyl alcohol, filtered, concentrated under reduced pressure, and allowed to stand in a cool place for aging. About 3% dry solids. Mocca extract: Extracted by refluxing with 50 v / v% ethyl alcohol, filtered, concentrated under reduced pressure, and allowed to stand in a cool place. About 2% dry solids. Iclinin extract: 50v / v% ethyl alcohol was added, and the mixture was extracted for 3 days at room temperature with occasional shaking, and then filtered,
Concentrated under reduced pressure. About 6% dry solids.

Example 1 A lotion containing 15% by weight of the drug shown in Table 1 and ethanol and the remainder being purified water was prepared and applied to the back of a colored guinea pig to examine its effect on inflammation and pigmentation due to sunburn. It was

(Test method) Colored guinea pigs (10 for each group)
The back of each animal was shaved and irradiated with ultraviolet rays under anesthesia. Ultraviolet irradiation is performed by Toshiba Corporation FL20S / BLB lamp and FL
Three 20S / E30 lamps were simultaneously irradiated, and the amount of ultraviolet rays was 4.8 × 10 ⁶ erg / cm ² . UV irradiation 24
0.2 ml each of the sample was rubbed well at four points on the back of the guinea pig before and immediately after the irradiation, and 12 hours and 24 hours after the irradiation. However, the application site was thoroughly washed with warm water before irradiation. The degree of inflammation was observed 24 hours after the irradiation, and after 7 days, the degree of pigmentation was observed and judged according to the following criteria.

(Criteria) Criteria for inflammation (anti-inflammatory effect) 0: No inflammation is observed at all. 1: Very slight inflammation is observed. 2: Inflammation is observed, but the boundary with the non-irradiated site is unclear. 3: Inflammation was observed and the boundary with the non-irradiated site was clear. Criteria for pigmentation (whitening effect) 0: No pigmentation is observed. 1: Very slight pigmentation is observed. 2: Pigmentation is observed, but the boundary with the non-irradiated site is unclear. 3: Pigmentation was observed, and the boundary with the non-irradiated site was clear.

[0021]

[Table 1]

(Judgment) 8 or more out of 10 guinea pigs each having a score of 1 or less: excellent effect 6 or more: effective 4 or more: moderately effective 3 or less: invalid results are shown in Table 2.

[0023]

[Table 2]

Example 2 In the same manner as in Example 1, the effects of the agents shown in Table 3 on inflammation and pigmentation due to sunburn were examined. The results are shown in Table 4.

[0025]

[Table 1]

[0026]

[Table 2]

From the results shown in Tables 2 and 4, the lotion of the present invention containing the components (A) and (B) is superior in anti-inflammatory effect and whitening effect as compared with the lotion containing each of them alone. I understand.

[0028]

[0029]

[0030]

[0031]

[0032]

[0033]

[0034]

INDUSTRIAL APPLICABILITY As described above in detail, the external preparation for skin of the present invention is excellent in the effect of suppressing skin inflammation due to sunburn and pigmentation after sunburn.

Continuation of the front page (51) Int.Cl. ⁷ Identification code FI A61K 35/78 A61K 35/78 C (72) Inventor Noriko Ida 48-18 Sakaemachi, Kita-ku, Tokyo (56) Reference Documents JP-A-3-236322 (JP, A) JP-A-3-236323 (JP, A) JP-A-62-298508 (JP, A) JP-A-3-127714 (JP, A) JP-A-3- 188008 (JP, A) JP-A-3-188013 (JP, A) JP-A-3-188014 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 7/00 A61K 7 / 48 A61K 35/78

Claims (3)

(57) [Claims] 1. An (A ₁ ) mica extract, and (B ₁ ) (a) Scutellaria barba extract, or (b) guaiazulene, ε-aminocaproic acid, or one or more of these derivatives. An anti-inflammatory and whitening skin external preparation characterized by the following: 2. An external anti-inflammatory and whitening skin preparation, which comprises (A ₂ ) mocca extract and (B ₂ ) elder extract. Wherein (A ₃₎ Ikurinin extract, and (B ₃₎ anti-inflammatory and whitening skin external agent characterized by containing cattail extract.