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JP2024506381A - 両親媒性ペプチドに基づく自己集合ナノ粒子 - Google Patents

両親媒性ペプチドに基づく自己集合ナノ粒子 Download PDF

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Publication number
JP2024506381A
JP2024506381A JP2023548865A JP2023548865A JP2024506381A JP 2024506381 A JP2024506381 A JP 2024506381A JP 2023548865 A JP2023548865 A JP 2023548865A JP 2023548865 A JP2023548865 A JP 2023548865A JP 2024506381 A JP2024506381 A JP 2024506381A
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JP
Japan
Prior art keywords
vaccine
peptide antigen
independently
amphiphile
vaccine according
Prior art date
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Pending
Application number
JP2023548865A
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English (en)
Japanese (ja)
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JPWO2022177993A5 (fr
Inventor
ジェフリー エム． リン，
ヴィンセント エル． コーブル，
サラ アール． ニコルス，
アンドリュー エス． イシヅカ，
ヒュー クラーク ウェルズ，
ロバート エヌ． ゴドゥ，
クリストファー マーティン オブライエン ガーリス，
ラミーロ アンドレイ ラミレス－バルデス，
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US Department of Health and Human Services
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US Department of Health and Human Services
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Publication of JP2024506381A publication Critical patent/JP2024506381A/ja
Publication of JPWO2022177993A5 publication Critical patent/JPWO2022177993A5/ja
Pending legal-status Critical Current

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  • Veterinary Medicine (AREA)
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  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
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  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023548865A 2021-02-16 2022-02-16 両親媒性ペプチドに基づく自己集合ナノ粒子 Pending JP2024506381A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163149996P 2021-02-16 2021-02-16
US63/149,996 2021-02-16
US202163197092P 2021-06-04 2021-06-04
US63/197,092 2021-06-04
PCT/US2022/016600 WO2022177993A1 (fr) 2021-02-16 2022-02-16 Nanoparticules auto-assemblées à base de peptides amphiphiles

Publications (2)

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JP2024506381A true JP2024506381A (ja) 2024-02-13
JPWO2022177993A5 JPWO2022177993A5 (fr) 2025-02-25

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US (1) US20250127887A1 (fr)
EP (1) EP4294431A4 (fr)
JP (1) JP2024506381A (fr)
KR (1) KR20230147135A (fr)
AU (1) AU2022224567A1 (fr)
BR (1) BR112023016402A2 (fr)
CA (1) CA3207998A1 (fr)
IL (1) IL305174A (fr)
MX (1) MX2023009417A (fr)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202317196A (zh) * 2021-06-16 2023-05-01 美商威克斯技術北美股份有限公司 用於藥物遞送應用之基於兩親性胜肽的自組裝奈米顆粒
WO2024092030A1 (fr) 2022-10-25 2024-05-02 Vaccitech North America, Inc. Nanoparticules à auto-assemblage
AU2023367778A1 (en) 2022-10-25 2025-05-01 Barinthus Biotherapeutics North America, Inc. Combination treatment regimes for treating cancer

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73534A (en) 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
US4880935A (en) 1986-07-11 1989-11-14 Icrf (Patents) Limited Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
FI102355B (fi) 1988-02-11 1998-11-30 Squibb Bristol Myers Co Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjug aattien valmistamiseksi
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
JP2000503639A (ja) 1995-12-22 2000-03-28 ブリストル―マイヤーズ スクイブ カンパニー 分枝ヒドラゾンのリンカー類
JP2000119271A (ja) 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
DE602006021608D1 (de) 2005-11-17 2011-06-09 Osi Pharm Inc Kondensierte bicyclische mtor-inhibitoren
US7902189B2 (en) 2006-08-23 2011-03-08 Astrazeneca Ab Compounds
US20080234262A1 (en) 2007-03-21 2008-09-25 Wyeth Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
EP2195022A4 (fr) * 2007-10-03 2012-08-01 Immunovaccine Technologies Inc Compositions comprenant un antigène, un composé amphipathique et un support hydrophobe, et leurs utilisations
CA2917512A1 (fr) * 2007-10-12 2009-04-23 Massachusetts Institute Of Technology Nanotechnologie des vaccins
CN102256966B (zh) 2008-10-17 2016-02-10 白头生物医学研究所 可溶性mTOR复合物和其调节剂
US8110578B2 (en) 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
DK3033102T4 (da) * 2013-08-13 2024-02-26 Univ Northwestern Peptidkonjugerede partikler
WO2017083963A1 (fr) * 2015-11-18 2017-05-26 Immunovaccine Technologies Inc. Systèmes adjuvant et compositions vaccinales sans eau comprenant un adjuvant de type polyi:c et un adjuvant lipidique
CA3057715A1 (fr) 2017-04-04 2018-10-11 Avidea Technologies, Inc. Vaccins a base de peptides, procedes de fabrication et utilisations de ceux-ci pour induire une reponse immunitaire
CA3113782A1 (fr) * 2018-10-03 2020-04-09 Avidea Technologies, Inc. Polymeres amphiphiles substitues par un noyau aromatique en tant que systemes d'administration de medicament
EP3966229A1 (fr) * 2019-05-10 2022-03-16 Victoria Link Ltd Vaccin glycopeptidique
US11723950B2 (en) * 2019-10-18 2023-08-15 Trustees Of Boston University CAL-T constructs and uses thereof
CA3240553A1 (fr) * 2022-01-10 2023-07-13 Yanay OFRAN Sous-unite glutenine de faible poids moleculaire modifiee et ses utilisations

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KR20230147135A (ko) 2023-10-20
EP4294431A4 (fr) 2025-05-07
BR112023016402A2 (pt) 2023-11-21
MX2023009417A (es) 2023-12-01
WO2022177993A1 (fr) 2022-08-25
CA3207998A1 (fr) 2022-08-25
US20250127887A1 (en) 2025-04-24
IL305174A (en) 2023-10-01
EP4294431A1 (fr) 2023-12-27

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