JP2024019506A - cosmetics - Google Patents
cosmetics Download PDFInfo
- Publication number
- JP2024019506A JP2024019506A JP2023209126A JP2023209126A JP2024019506A JP 2024019506 A JP2024019506 A JP 2024019506A JP 2023209126 A JP2023209126 A JP 2023209126A JP 2023209126 A JP2023209126 A JP 2023209126A JP 2024019506 A JP2024019506 A JP 2024019506A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- inulin
- extract
- oil
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 71
- -1 sucrose fatty acid ester Chemical class 0.000 claims abstract description 205
- 229920001202 Inulin Polymers 0.000 claims abstract description 166
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 165
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 20
- 229920002674 hyaluronan Polymers 0.000 claims description 20
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- 239000000839 emulsion Substances 0.000 claims description 13
- 241000233866 Fungi Species 0.000 claims description 11
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- 229940113118 carrageenan Drugs 0.000 claims description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 64
- 238000002360 preparation method Methods 0.000 description 56
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- 235000002639 sodium chloride Nutrition 0.000 description 44
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- 150000003839 salts Chemical class 0.000 description 35
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 33
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 29
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 22
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Abstract
Description
本発明は化粧料に関する。 The present invention relates to cosmetics.
イヌリンは多糖類の一種で、広く自然界に分布しており、ダリア、キクイモ、オグルマなどのキク科植物の塊茎やチコリの根などにコロイド状に存在している。その構造は、スクロースのフルクトース側にD-フルクトースがβ-(2→1)結合で脱水重合したものである。このような植物由来のイヌリンは、植物の種類によって多少の差異があるものの、その重合度の分布としては約8~60の範囲にあり、平均重合度は約30前後であることが知られている。 Inulin is a type of polysaccharide that is widely distributed in nature, and is present in colloidal form in the tubers of Asteraceae plants such as dahlias, Jerusalem artichokes, and Asteraceae, and in the roots of chicory. Its structure is that D-fructose is dehydrated and polymerized with a β-(2→1) bond on the fructose side of sucrose. Although there are some differences depending on the type of plant, the degree of polymerization of such plant-derived inulin ranges from about 8 to 60, and the average degree of polymerization is known to be around 30. There is.
イヌリンを製造する方法としては、前述のような植物から抽出する方法が知られており、工業的にも利用されている。また、上記のようなイヌリンを抽出し得る高等植物には当然のことながらイヌリンを生成する酵素が含まれており、そのような植物から抽出して得られた酵素を使用してイヌリンを生成する方法が知られているが、植物体より酵素を大量に調製するのはかなりの時間と労力を要するが故に、工業規模での利用は現実的ではない。
また別の方法として、微生物の酵素を利用してイヌリン類似物を製造する方法が知られている。例えば、アスペルギルス・シドウィ(Aspergillus sydowi)の分生胞子又は菌体処理してイヌリンタイプの構造を有する物質を得る方法や、アスペルギルス(Aspergillus)属又はフザリウム(Fusarium)属に属する微生物の産生する酵素によりイヌリン類似物を得る方法、ストレプトコッカス・ミュータンス(Streptococcus mutans)に属する微生物の産生する酵素によりイヌリン類似物を得る方法などが報告されている(特許文献1の背景技術参照)。しかしながら、これらの微生物の酵素を用いて生成される化合物は、イヌリンと同様にフルクトースがβ-(2→1)結合で脱水重合した構造を主とするが、その性質が植物由来のイヌリンとは大きく異なるため(その分子が巨大である、あるいは結合形式が異なる等)、イヌリンと区別してイヌリン型ポリフラクタンと呼ばれる。
As a method for producing inulin, the method of extracting it from plants as described above is known and is also used industrially. Furthermore, the higher plants from which inulin can be extracted as mentioned above naturally contain enzymes that produce inulin, and the enzymes extracted from such plants can be used to produce inulin. Although methods are known, it is not practical to use on an industrial scale because it takes a considerable amount of time and effort to prepare enzymes in large quantities from plants.
Another known method is to use microbial enzymes to produce inulin analogs. For example, a method for obtaining a substance having an inulin-type structure by treating conidia or bacterial cells of Aspergillus sydowi, or using an enzyme produced by a microorganism belonging to the genus Aspergillus or Fusarium. A method for obtaining an inulin analog and a method for obtaining an inulin analog using an enzyme produced by a microorganism belonging to Streptococcus mutans have been reported (see Background Art of Patent Document 1). However, the compounds produced using the enzymes of these microorganisms mainly have a structure in which fructose is dehydrated and polymerized with β-(2→1) bonds, similar to inulin, but their properties are different from that of plant-derived inulin. Because it is very different (the molecule is huge, the bonding form is different, etc.), it is called an inulin-type polyfructan to distinguish it from inulin.
一方で近年、微生物の酵素を用いてイヌリンを製造する新たな方法として、バチラス属に属する微生物に由来する酵素を用いる方法が開発されている(特許文献1、2)。この方法によると、植物由来のイヌリンと同構造で平均分子量の近いイヌリン組成物を得ることが可能である。また、合成条件を調整することで平均重合度を制御することができ、かつ、重合度の分布が狭いイヌリンを得ることができる。このような方法で得られるイヌリンについては、主に食品への利用が試みられている(例えば特許文献3、4、非特許文献1)。
On the other hand, in recent years, a method using an enzyme derived from a microorganism belonging to the genus Bacillus has been developed as a new method for producing inulin using a microorganism enzyme (Patent Documents 1 and 2). According to this method, it is possible to obtain an inulin composition having the same structure and similar average molecular weight to plant-derived inulin. Moreover, by adjusting the synthesis conditions, the average degree of polymerization can be controlled, and inulin with a narrow distribution of the degree of polymerization can be obtained. Inulin obtained by such a method has been mainly attempted to be used in foods (for example,
イヌリンの化粧品への応用としては、特許文献5にイヌリンを配合した皮膚化粧料が開示されており、べたつきがなく、なじみのよい保湿剤として有用であることが記載されている。この文献で使用されているイヌリンはアスペルギルス・シドウィの分生胞子を用いて得られたものであり、その分子量は10,000~10,000,000と記載されている。特許文献6、7にはイヌリン又はその誘導体が、皮膚細胞に対して種々の生理活性を有することが記載されている。これらの文献で使用されているイヌリンは植物由来のものであり、その平均重合度は5~30と記載されている。特許文献8にはイヌリンをリンスオフ化粧品のコンディショニング剤として、陽イオン重合体の代替として有用であることが記載されている。この文献で使用されているイヌリンはチコリ由来ものであり、重合度が2~70の範囲で、平均重合度が10~12と記載されている。すなわち、植物由来のイヌリンや従来から知られている微生物の酵素に由来するイヌリン型ポリフラクタンについては、化粧品用途への応用はすでに知られている。しかしながら、これらの植物由来のイヌリンや微生物の酵素に由来するイヌリン型ポリフラクタンは、化粧品での使用にあたって、水への溶解性が十分でなく、処方中での析出や濁りの原因となる問題があり、また使用感も必ずしも満足いくものではなかった。
As for the application of inulin to cosmetics, Patent Document 5 discloses a skin cosmetic containing inulin, and describes that it is useful as a non-sticky and well-blended moisturizing agent. The inulin used in this document is obtained using conidia of Aspergillus sydowii, and its molecular weight is described as 10,000 to 10,000,000.
上記のような事情に鑑み、本発明の目的とするところは、水への溶解性が高く、処方中の安定性に優れ、使用感にも優れる化粧料を提供することにある。 In view of the above circumstances, it is an object of the present invention to provide a cosmetic that has high solubility in water, excellent stability during formulation, and excellent feel when used.
本発明者らは上記目的を達成すべく鋭意研究を重ねた結果、全イヌリンの平均重合度が13~23であり、全イヌリン100質量%中、重合度が5~29のイヌリンを95質量%以上含むイヌリン組成物を使用することで、水への溶解性が高く、処方中の安定性に優れ、使用感にも優れる化粧料を提供できることを見出した。本発明者らは、かかる知見に基づきさらに研究を重ね、本発明を完成するに至った。 As a result of intensive research to achieve the above object, the present inventors found that the average degree of polymerization of all inulin was 13 to 23, and that 95% by mass of inulin with a degree of polymerization of 5 to 29 out of 100% by mass of total inulin. It has been found that by using the inulin composition containing the above, it is possible to provide a cosmetic that has high solubility in water, excellent stability during formulation, and excellent feel on use. Based on this knowledge, the present inventors conducted further research and completed the present invention.
即ち、本発明は、以下の化粧料を提供する。
項1.
全イヌリンの平均重合度が13~23であり、
全イヌリン100質量%中、重合度が5~29のイヌリンを95質量%以上含むイヌリン組成物を含有することを特徴とする化粧料。
項2.
さらに水溶性多糖類を含有する、項1に記載の化粧料。
項3.
前記水溶性多糖類がシロキクラゲ多糖体、ヒアルロン酸、及びキサンタンガムからなる群から選択される1種以上である、項2に記載の化粧料。
項4.
皮膚洗浄剤である、項1~3の何れかに記載の化粧料。
That is, the present invention provides the following cosmetics.
Item 1.
The average degree of polymerization of all inulin is 13 to 23,
A cosmetic comprising an inulin composition containing 95% by mass or more of inulin with a degree of polymerization of 5 to 29 based on 100% by mass of total inulin.
Item 2.
Item 2. The cosmetic according to Item 1, further comprising a water-soluble polysaccharide.
Item 3.
3. The cosmetic according to item 2, wherein the water-soluble polysaccharide is one or more selected from the group consisting of white fungus polysaccharide, hyaluronic acid, and xanthan gum.
Item 3. The cosmetic according to any one of Items 1 to 3, which is a skin cleansing agent.
本発明に係る化粧料によれば、水への溶解性が高く、処方中の安定性に優れ、使用感にも優れる化粧料を提供することができる。 According to the cosmetic composition according to the present invention, it is possible to provide a cosmetic composition that has high solubility in water, excellent stability during formulation, and excellent usability.
本発明の化粧料は、全イヌリンの平均重合度が13~23であり、全イヌリン100質量%中、重合度が5~29のイヌリンを95質量%以上含むイヌリン組成物を含むことを特徴とする。 The cosmetic composition of the present invention is characterized by containing an inulin composition in which the average degree of polymerization of total inulin is 13 to 23, and 95% by mass or more of inulin with a degree of polymerization of 5 to 29 based on 100% by mass of total inulin. do.
イヌリン組成物
本発明において使用するイヌリン組成物は、平均重合度が制御されたものであり、さらに、重合度の分布が狭いことを特徴とする。
Inulin Composition The inulin composition used in the present invention is characterized by a controlled average degree of polymerization and a narrow distribution of the degree of polymerization.
より具体的には、本発明において使用するイヌリン組成物は、該イヌリン組成物に含まれる全イヌリンの平均重合度が13~23であり、且つ、全イヌリン100質量%中、重合度が5~29のイヌリンを95質量%以上含む。かかるイヌリン組成物を化粧料に使用することで、従来品と比較し、高い溶解性や優れた使用感、さらに、表皮ヒアルロン酸産生促進や泡質改善といった優れた効果を発揮することができる。 More specifically, the inulin composition used in the present invention has an average degree of polymerization of all inulin contained in the inulin composition of 13 to 23, and a degree of polymerization of 5 to 23 in 100% by mass of the total inulin. Contains 95% by mass or more of 29 inulin. By using such an inulin composition in cosmetics, it is possible to exhibit superior effects such as higher solubility and better feeling of use, as well as promotion of epidermal hyaluronic acid production and improvement of foam quality, compared to conventional products.
本明細書において、得られるイヌリンの平均重合度の分析は、以下のようにして行うことができる。尚、重合度とは、イヌリン中のサッカライド単位(フルクトース及びグルコース単位)の数であり、平均重合度は、例えば、以下のようにして、HPLC、GC、HPAEC等の通常の分析法によって求めた各分析結果のピークの内のトップを平均重合度としたものである。カラムとして、例えば、信和化工製のULTRON PS-80N(8×300mm)(溶媒;水、流速;0.5ml/min、温度;50℃)あるいは、TOSOH製のTSK-GEL G30000 PWXL(7.8×300mm)(溶媒;水、流速;0.5ml/min、温度;50℃)を用い、検出器として示差屈折計を使用することによって確認された、生成イヌリンの重合度を標準物質として、例えば、植物由来のイヌリンであるオラフティ社のラフティリンST(平均重合度11)とラフティリンHP(平均重合度22)を用いて作成した検量線により求めることができる。なお、イヌリンの重合度の分析に関しては、Loo等(Critical Reviews in Food Science and Nutrition、 35(6)、525-552(1995))の方法に基づいて実施することができる。 In this specification, the average degree of polymerization of the obtained inulin can be analyzed as follows. In addition, the degree of polymerization is the number of saccharide units (fructose and glucose units) in inulin, and the average degree of polymerization is determined by a conventional analytical method such as HPLC, GC, HPAEC, etc., for example, as follows. The top of the peaks in each analysis result is taken as the average degree of polymerization. Examples of columns include ULTRON PS-80N (8 x 300 mm) manufactured by Shinwa Kako (solvent: water, flow rate: 0.5 ml/min, temperature: 50°C) or TSK-GEL G30000 PWXL (7.8 mm) manufactured by TOSOH. x 300 mm) (solvent: water, flow rate: 0.5 ml/min, temperature: 50°C), and the degree of polymerization of the produced inulin, which was confirmed by using a differential refractometer as a detector, was used as a standard substance, e.g. , can be determined using a calibration curve created using Laftilin ST (average degree of polymerization 11) and Laftilin HP (average degree of polymerization 22) manufactured by Orafty, which are plant-derived inulins. The degree of polymerization of inulin can be analyzed based on the method of Loo et al. (Critical Reviews in Food Science and Nutrition, 35(6), 525-552 (1995)).
イヌリン組成物の平均重合度が13よりも小さいとさらさら感を付与する効果が十分ではなく、また、泡質改善効果が十分に発揮されない。逆に平均重合度が23よりも大きいと、水への溶解性が乏しくなり、また、べたつき感が強くなるため好ましくない。 If the average degree of polymerization of the inulin composition is less than 13, the effect of imparting a dry feeling will not be sufficient, and the effect of improving foam quality will not be sufficiently exhibited. On the other hand, if the average degree of polymerization is greater than 23, the solubility in water becomes poor and the sticky feeling becomes strong, which is not preferable.
さらに本発明の効果を発揮させる点においては、平均重合度のみならず、重合度の分布が狭いことが重要であり、本発明の重合度の範囲外のものを多く含まないことが好ましい。具体的には、本発明の化粧料に含まれるイヌリン組成物は、全イヌリン100質量%中、重合度が5~29のイヌリンを95質量%以上含む。重合度の分布が広くなると、本発明の重合度の範囲外となる重合度の小さいものや大きいものが多く含まれることとなる。重合度の小さいものが多いとさらさら感を付与する効果が十分ではなくなり、泡質改善効果が十分に発揮されず、逆に重合度の大きいものが多いと水への溶解性が乏しくなり、べたつき感が強くなるため好ましくない。 Furthermore, in order to exhibit the effects of the present invention, it is important that not only the average degree of polymerization but also the distribution of the degree of polymerization is narrow, and it is preferable not to contain much of the degree of polymerization outside the range of the degree of polymerization of the present invention. Specifically, the inulin composition contained in the cosmetic of the present invention contains 95% by mass or more of inulin with a degree of polymerization of 5 to 29 based on 100% by mass of the total inulin. When the distribution of the degree of polymerization becomes wide, many substances with a low or high degree of polymerization which are outside the range of the degree of polymerization of the present invention will be included. If there are many substances with a low degree of polymerization, the effect of imparting a dry feeling will not be sufficient, and the foam quality improvement effect will not be fully demonstrated.On the other hand, if there are many substances with a high degree of polymerization, the solubility in water will be poor, resulting in stickiness. This is not preferable because the feeling becomes strong.
かかるイヌリン組成物は、例えば、バチラス属に属する微生物に由来する酵素を用いて製造することができる。具体的には、特許文献1、2に記載されているとおりであるが、その要旨は以下に説明するとおりである。 Such an inulin composition can be produced using, for example, an enzyme derived from a microorganism belonging to the genus Bacillus. Specifically, it is as described in Patent Documents 1 and 2, and the gist thereof is as explained below.
まず、イヌリン合成酵素について説明すると、バチラス属に属する微生物に由来する酵素、より具体的には、バチラスsp. 217C-11株(FERM BP-7450)の培養液若しくは培養菌体又はその処理物から得られるものを用いることができる。このバチラスsp.217C-11株の培養法及び酵素の調製方法について、以下で簡単に説明する。 First, to explain inulin synthase, an enzyme derived from a microorganism belonging to the genus Bacillus, more specifically, an enzyme derived from a culture solution or cultured bacterial cells of Bacillus sp. 217C-11 strain (FERM BP-7450), or a processed product thereof. You can use what you can get. The method for culturing this Bacillus sp. 217C-11 strain and the method for preparing the enzyme will be briefly explained below.
イヌリン合成酵素の培養法において、培地に添加する炭素源としては、通常に使用されるものを適当な濃度で使用すればよい。例えば、スクロース、グルコース、フルクトース、マルトース等の糖質を単独又は混合して用いることができるが、最も好ましい炭素源はスクロースである。これを主炭素源とした液体培地を用いて培養することにより当該酵素活性は向上する。窒素源としては、ペプトン、肉エキス、酵母エキス、コーン・スティープ・リカー等の有機窒素源のほか、硫酸、硝酸、リン酸のアンモニウム塩等の無機窒素源を単独又は混合して用いることができる。無機塩類としては、カリウム、ナトリウム、カルシウム、マグネシウム、マンガン、鉄等の硫酸塩、塩酸塩、炭酸塩、硝酸塩、リン酸塩等をそれぞれ単独で、又は組み合わせて用いることができる。更に必要に応じて、アミノ酸、ビタミン等の通常の培養に用いられる栄養源等も適宜用いることができる。具体的な培地としては、スクロースを0.5~2%(w/v)、ペプトンを1%、酵母エキスを0.5%、リン酸2カリウムを0.2%で含む、pHが7~8の液体培地を用いることができる。 In the method for culturing inulin synthase, commonly used carbon sources may be used at appropriate concentrations as the carbon source added to the medium. For example, carbohydrates such as sucrose, glucose, fructose, and maltose can be used alone or in combination, but the most preferred carbon source is sucrose. The enzyme activity is improved by culturing in a liquid medium using this as the main carbon source. As a nitrogen source, in addition to organic nitrogen sources such as peptone, meat extract, yeast extract, and corn steep liquor, inorganic nitrogen sources such as sulfuric acid, nitric acid, and ammonium salts of phosphoric acid can be used alone or in combination. . As the inorganic salts, sulfates, hydrochlorides, carbonates, nitrates, phosphates, etc. of potassium, sodium, calcium, magnesium, manganese, iron, etc. can be used alone or in combination. Furthermore, if necessary, nutrients such as amino acids and vitamins used in normal culture can also be used as appropriate. A specific medium contains 0.5 to 2% (w/v) sucrose, 1% peptone, 0.5% yeast extract, and 0.2% dipotassium phosphate, and has a pH of 7 to 7. 8 liquid media can be used.
培養は振とう式で、又はジャー・ファーメンターを用いて通気条件下で行うことができる。培地のpHは6~9の範囲が好ましく、培養温度は25℃~37℃の範囲が好ましく、培養時間は微生物が増殖し得る以上の時間であればよく、5~96時間、好ましくは15~72時間である。バチラスsp.217C-11株を先に示した培地で培養後、遠心分離により除菌し、その後に培養上清を分画分子量が30,000の限外濾過膜を用いて濃縮し、反応用の酵素液として使用することができる。このバチラスsp.217C-11株由来のイヌリン合成酵素は、以下の理化学的性質を有するものである。
分子量:45,000~50,000
至適温度:40~50℃
熱安定性:45℃を越えると徐々に失活し始め、50℃で70%、60℃
で40%の残存活性を示す
至適pH:7~8(45℃)
pH安定性:pH6以上で安定
Cultivation can be carried out with shaking or under aerated conditions using a jar fermenter. The pH of the medium is preferably in the range of 6 to 9, the culture temperature is preferably in the range of 25 to 37 degrees Celsius, and the culture time may be any time longer than the time at which microorganisms can proliferate, preferably 5 to 96 hours, preferably 15 to 96 hours. It is 72 hours. After culturing Bacillus sp. 217C-11 strain in the medium shown above, bacteria were removed by centrifugation, and the culture supernatant was concentrated using an ultrafiltration membrane with a molecular weight cutoff of 30,000. It can be used as an enzyme solution. This inulin synthase derived from Bacillus sp. 217C-11 strain has the following physicochemical properties.
Molecular weight: 45,000-50,000
Optimal temperature: 40-50℃
Thermal stability: When the temperature exceeds 45℃, it starts to gradually lose its activity, 70% at 50℃, and 70% at 60℃
Shows 40% residual activity at optimum pH: 7-8 (45℃)
pH stability: Stable at pH 6 or higher
なお、このイヌリン合成酵素は、スクロースに作用してイヌリンを生成するが、ケストース、マルトース、ラクトース、トレハロース、セロビオースには作用しない作用及び基質特異性を有するものである。 Note that this inulin synthase acts on sucrose to produce inulin, but has an action and substrate specificity that does not act on kestose, maltose, lactose, trehalose, or cellobiose.
次に上記のようにして得られたイヌリン合成酵素を用いて、イヌリン組成物を製造する方法について説明する。イヌリン合成酵素の濃度は、反応液中のスクロース(基質)を十分に利用し得る濃度であればよく、例えば、スクロース40~60%(w/w)の場合、イヌリン合成酵素の活性が0.4unit/mLの反応液となる濃度とするのが好ましい。スクロースを基質としてイヌリンを生成するのに適切な条件は、pHが6~8の範囲の反応液を用いるのが好ましい。更に該反応液のpHを保つためにリン酸緩衝液を用いることもできる。反応時間は、イヌリン合成酵素の使用量等により適宜変更することができるが、通常0.1~100時間、好ましくは0.5~72時間である。 Next, a method for producing an inulin composition using the inulin synthase obtained as described above will be described. The concentration of inulin synthase may be any concentration that can sufficiently utilize sucrose (substrate) in the reaction solution. For example, when sucrose is 40 to 60% (w/w), the activity of inulin synthase is 0.5%. It is preferable to set the concentration to a reaction solution of 4 units/mL. As for conditions suitable for producing inulin using sucrose as a substrate, it is preferable to use a reaction solution with a pH in the range of 6 to 8. Furthermore, a phosphate buffer can also be used to maintain the pH of the reaction solution. The reaction time can be changed as appropriate depending on the amount of inulin synthase used, etc., but is usually 0.1 to 100 hours, preferably 0.5 to 72 hours.
イヌリン組成物の製造において、(1)スクロース濃度の調整、(2)イヌリン合成酵素をスクロースに接触させる際の温度の調整、(3)スクロースの追添加により、生成されるイヌリンの平均重合度を調節することができる。 In the production of inulin compositions, the average degree of polymerization of the produced inulin can be adjusted by (1) adjusting the sucrose concentration, (2) adjusting the temperature when bringing inulin synthase into contact with sucrose, and (3) adding sucrose. Can be adjusted.
上記(1)スクロース濃度の調整について更に説明すると、スクロース濃度の調整は、イヌリン合成酵素をスクロースに接触させてイヌリンを合成するに際し、生成するイヌリンの平均重合度に対応して行なわれる。具体的なスクロース濃度は、例えば、3~68%(w/w)、好ましくは10~60%(w/w)の範囲であるが、スクロース濃度を上記の範囲内で低く設定することによって、得られるイヌリンの平均重合度を高めることができる。例えば、反応温度が15℃の場合、原料のスクロース濃度が50%のときに得られるイヌリンの平均重合度は10であるのに対し、原料のスクロース濃度が20%のときに得られるイヌリンの平均重合度は18である。また、反応温度が37℃の場合、原料のスクロース濃度が60%のときに得られるイヌリンの平均重合度は9であるのに対し、原料のスクロース濃度が20%のときに得られるイヌリンの平均重合度は20である。従って、スクロース濃度を適宜設定することによって、所望の平均重合度のイヌリンを得ることができる。 To further explain the above (1) adjustment of sucrose concentration, the sucrose concentration is adjusted in accordance with the average degree of polymerization of inulin produced when inulin synthase is brought into contact with sucrose to synthesize inulin. A specific sucrose concentration is, for example, in the range of 3 to 68% (w/w), preferably 10 to 60% (w/w), but by setting the sucrose concentration low within the above range, The average degree of polymerization of the resulting inulin can be increased. For example, when the reaction temperature is 15°C, the average degree of polymerization of inulin obtained when the sucrose concentration of the raw material is 50% is 10, whereas the average degree of polymerization of inulin obtained when the sucrose concentration of the raw material is 20%. The degree of polymerization is 18. Furthermore, when the reaction temperature is 37°C, the average degree of polymerization of inulin obtained when the sucrose concentration of the raw material is 60% is 9, whereas the average degree of polymerization of inulin obtained when the sucrose concentration of the raw material is 20%. The degree of polymerization is 20. Therefore, by appropriately setting the sucrose concentration, inulin with a desired average degree of polymerization can be obtained.
反応液中に生成されたイヌリンは、公知の方法に従い精製することができる。例えば、得られた反応液をイオン交換樹脂あるいは活性炭等で精製し、これを減圧濃縮あるいは逆浸透膜によって濃縮し、次いで冷却してイヌリンの結晶を得ることにより実施することができる。あるいは、反応液にエタノールなどの有機溶媒を添加することにより、イヌリンを沈殿させて回収することも可能であるが、これらに限定されない。 Inulin produced in the reaction solution can be purified according to known methods. For example, it can be carried out by purifying the obtained reaction solution using an ion exchange resin or activated carbon, concentrating it under reduced pressure or using a reverse osmosis membrane, and then cooling it to obtain inulin crystals. Alternatively, inulin can be precipitated and recovered by adding an organic solvent such as ethanol to the reaction solution, but the method is not limited thereto.
イヌリン組成物の化粧料への配合量としては、本発明の効果を損なわない範囲であれば特に制限はなく、通常0.01~30質量%、好ましくは、0.05~15質量%である。 The amount of inulin composition to be added to cosmetics is not particularly limited as long as it does not impair the effects of the present invention, and is usually 0.01 to 30% by mass, preferably 0.05 to 15% by mass. .
水溶性多糖類
本発明のイヌリン組成物を配合した化粧料には、さらに水溶性多糖類を配合することが好ましい。水溶性多糖類としては、具体的には、シロキクラゲ多糖体、ヒアルロン酸、キサンタンガム、アルギン酸、グアーガム、カチオン化グアーガム、カラギーナン、ジェランガム、アガロース、カルボキシメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、セルロースナノファイバー等が挙げられ、シロキクラゲ多糖体、ヒアルロン酸、キサンタンガムが最も好ましい。このような水溶性多糖類を併用することで、本発明のイヌリン組成物の処方中での析出や濁りを低減することができ、さらに泡質改善効果を増強することが可能である。水溶性多糖類の配合量としては、本発明の効果を損なわない範囲であれば特に制限はないが、イヌリン組成物と水溶性多糖類の併用による効果を十分発揮させる観点から、イヌリン組成物の配合量に対して、通常0.001~2質量倍、好ましくは0.002~1質量倍を、最も好ましくは0.005~0.5質量倍配合するとよい。イヌリン組成物と水溶性多糖類を併用する場合、それぞれを化粧料に配合してもよいし、あるいは、イヌリン組成物と水溶性多糖類を水に溶解させたプレミックス組成物を調製し、このようなプレミックス組成物を化粧料に配合してもよい。プレミックス組成物には必要に応じて、さらに防腐剤、pH調整・緩衝剤、保湿剤等を添加することができる。
Water-soluble polysaccharide It is preferable that a cosmetic containing the inulin composition of the present invention further contains a water-soluble polysaccharide. Specific examples of water-soluble polysaccharides include white fungus polysaccharide, hyaluronic acid, xanthan gum, alginic acid, guar gum, cationized guar gum, carrageenan, gellan gum, agarose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, and cellulose nanofiber. Among them, white fungus polysaccharide, hyaluronic acid, and xanthan gum are most preferred. By using such a water-soluble polysaccharide in combination, it is possible to reduce precipitation and turbidity in the formulation of the inulin composition of the present invention, and it is also possible to enhance the foam quality improving effect. There is no particular restriction on the amount of the water-soluble polysaccharide as long as it does not impair the effects of the present invention. It is usually 0.001 to 2 times by weight, preferably 0.002 to 1 times by weight, and most preferably 0.005 to 0.5 times by weight based on the blended amount. When using an inulin composition and a water-soluble polysaccharide together, each may be blended into the cosmetic, or a premix composition in which the inulin composition and the water-soluble polysaccharide are dissolved in water is prepared, and the inulin composition and the water-soluble polysaccharide are dissolved in water. Such premix compositions may be incorporated into cosmetics. Preservatives, pH adjusting/buffering agents, humectants, etc. can be further added to the premix composition as necessary.
本発明の化粧料には、必要に応じて水及び通常化粧料に配合される添加成分、例えば油性基剤、界面活性剤、アルコール類、保湿剤、高分子・増粘・ゲル化剤、酸化防止剤、防腐剤、殺菌剤、キレート剤、pH調整剤・酸・アルカリ、紫外線吸収剤、美白剤、溶剤、角質剥離・溶解剤、鎮痒剤、消炎剤、制汗剤、清涼剤、抗ヒスタミン剤、収れん剤、刺激剤、育毛用薬剤・血行促進剤、還元剤・酸化剤、高分子粉体、ヒドロキシ酸、ビタミン類及びその誘導体類、糖類及びその誘導体類、有機酸類、酵素類、核酸類、ホルモン類、無機粉体類、香料、色素等を本発明の効果を損なわない程度で含有していてもよい。 The cosmetics of the present invention may optionally contain water and additive ingredients normally added to cosmetics, such as oily bases, surfactants, alcohols, humectants, polymers/thickening/gelling agents, oxidizing agents, etc. Preventive agents, preservatives, bactericidal agents, chelating agents, pH adjusters/acids/alkali, ultraviolet absorbers, whitening agents, solvents, exfoliating/dissolving agents, antipruritic agents, anti-inflammatory agents, antiperspirants, refreshing agents, antihistamines, Astringents, stimulants, hair growth agents/blood circulation promoters, reducing agents/oxidizing agents, polymer powders, hydroxy acids, vitamins and their derivatives, sugars and their derivatives, organic acids, enzymes, nucleic acids, Hormones, inorganic powders, fragrances, pigments, etc. may be contained to the extent that they do not impair the effects of the present invention.
油性基剤としては、セタノール、ミリスチルアルコール、オレイルアルコール、ラウリルアルコール、セトステアリルアルコール、ステアリルアルコール、アラキルアルコール、ベヘニルアルコール、ホホバアルコール、キミルアルコール、セラキルアルコール、バチルアルコール、ヘキシルデカノール、イソステアリルアルコール、2-オクチルドデカノール、ダイマージオール等の高級アルコール類;ベンジルアルコール等のアラルキルアルコール及び誘導体;ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、イソステアリン酸、ベヘン酸、ウンデシレン酸、12-ヒドロキシステアリン酸、パルミトオレイン酸、オレイン酸、リノール酸、リノレイン酸、エルカ酸、ドコサヘキサエン酸、エイコサペンタエン酸、イソヘキサデカン酸、アンテイソヘンイコサン酸、長鎖分岐脂肪酸、ダイマー酸、水素添加ダイマー酸等の高級脂肪酸類及びそのアルミニウム塩、カルシウム塩、マグネシウム塩、亜鉛塩、カリウム、ナトリウム塩等の金属石けん類、及びアミド等の含窒素誘導体類;流動パラフィン(ミネラルオイル)、重質流動イソパラフィン、軽質流動イソパラフィン、α-オレフィンオリゴマー、ポリイソブテン、水添ポリイソブテン、ポリブテン、スクワラン、オリーブ由来スクワラン、スクワレン、ワセリン、固形パラフィン等の炭化水素類;キャンデリラワックス、カルナウバワックス、ライスワックス、木ろう、みつろう、モンタンワックス、オゾケライト、セレシン、パラフィンワックス、マイクロクリスタリンワックス、ペトロラタム、フィッシャートロプシュワックス、ポリエチレンワックス、エチレン・プロピレンコポリマー等のワックス類;ヤシ油、パーム油、パーム核油、サフラワー油、オリーブ油、ヒマシ油、アボカド油、ゴマ油、茶油、月見草油、小麦胚芽油、マカデミアナッツ油、ヘーゼルナッツ油、ククイナッツ油、ローズヒップ油、メドウフォーム油、パーシック油、ティートリー油、ハッカ油、トウモロコシ油、ナタネ油、ヒマワリ油、小麦胚芽油、アマニ油、綿実油、大豆油、落花生油、コメヌカ油、カカオ脂、シア脂、水素添加ヤシ油、水素添加ヒマシ油、ホホバ油、水素添加ホホバ油等の植物油脂類;牛脂、乳脂、馬脂、卵黄油、ミンク油、タートル油等の動物性油脂類;鯨ロウ、ラノリン、オレンジラッフィー油等の動物性ロウ類;液状ラノリン、還元ラノリン、吸着精製ラノリン、酢酸ラノリン、酢酸液状ラノリン、ヒドロキシラノリン、ポリオキシエチレンラノリン、ラノリン脂肪酸、硬質ラノリン脂肪酸、ラノリンアルコール、酢酸ラノリンアルコール、酢酸(セチル・ラノリル)エステル等のラノリン類;レシチン、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、ホスファチジルグリセロール、ホスファチジルイノシトール、スフィンゴミエリン等のスフィンゴリン脂質、ホスファチジン酸、環状リゾホスファチジン酸またはその塩、リゾレシチン等のリン脂質類;水素添加大豆リン脂質、部分水素添加大豆リン脂質、水素添加卵黄リン脂質、部分水素添加卵黄リン脂質等のリン脂質誘導体類;コレステロール、ジヒドロコレステロール、ラノステロール、ジヒドロラノステロール、フィトステロール、コール酸等のステロール類;サポゲニン類;サポニン類;酢酸コレステリル、ノナン酸コレステリル、ステアリン酸コレステリル、イソステアリン酸コレステリル、オレイン酸コレステリル、N-ラウロイル-L-グルタミン酸ジ(コレステリル/ベヘニル/オクチルドデシル)、N-ラウロイル-L-グルタミン酸ジ(コレステリル/オクチルドデシル)、N-ラウロイル-L-グルタミン酸ジ(フィトステリル/ベヘニル/オクチルドデシル)、N-ラウロイル-L-グルタミン酸ジ(フィトステリル/オクチルドデシル)、N-ラウロイルサルコシンイソプロピル等のアシルサルコシンアルキルエステル、12-ヒドロキシステアリン酸コレステリル、マカデミアナッツ油脂肪酸コレステリル、マカデミアナッツ油脂肪酸フィトステリル、ヒマワリ種子油脂肪酸フィトステリル、イソステアリン酸フィトステリル、軟質ラノリン脂肪酸コレステリル、硬質ラノリン脂肪酸コレステリル、長鎖分岐脂肪酸コレステリル、長鎖α-ヒドロキシ脂肪酸コレステリル等のステロールエステル類;リン脂質・コレステロール複合体、リン脂質・フィトステロール複合体等の脂質複合体;ミリスチン酸オクチルドデシル、ミリスチン酸ヘキシルデシル、イソステアリン酸オクチルドデシル、パリミチン酸セチル、パルミチン酸オクチルドデシル、オクタン酸セチル、オクタン酸ヘキシルデシル、イソノナン酸イソトリデシル、イソノナン酸イソノニル、イソノナン酸オクチル、イソノナン酸イソトリデシル、ネオペンタン酸イソデシル、ネオペンタン酸イソトリデシル、ネオペンタン酸イソステアリル、ネオデカン酸オクチルドデシル、オレイン酸オレイル、オレイン酸オクチルドデシル、リシノレイン酸オクチルドデシル、ラノリン脂肪酸オクチルドデシル、炭酸ジカプリリル、ジメチルオクタン酸ヘキシルデシル、エルカ酸オクチルドデシル、イソステアリン酸硬化ヒマシ油、オレイン酸エチル、アボカド油脂肪酸エチル、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、パルミチン酸オクチル、イソステアリン酸イソプロピル、ラノリン脂肪酸イソプロピル、ラウリン酸メチルヘプチル、ミリスチン酸メチルヘプチル、パルミチン酸メチルヘプチル、イソステアリン酸メチルヘプチル、セバシン酸ジエチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、アジピン酸ジイソプロピル、セバシン酸ジブチルオクチル、アジピン酸ジイソブチル、コハク酸ジオクチル、クエン酸トリエチル等のモノアルコールカルボン酸エステル類;乳酸セチル、リンゴ酸ジイソステアリル、モノイソステアリン酸水添ヒマシ油、γ-エルカラクトン等のオキシ酸エステル類;トリオクタン酸グリセリル、トリオレイン酸グリセリル、トリイソステアリン酸グリセリル、ジイソステアリン酸グリセリル、トリ(カプリル酸/カプリン酸)グリセリル、トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリル、水添ロジントリグリセリド(水素添加エステルガム)、ロジントリグリセリド(エステルガム)、ベヘン酸エイコサン二酸グリセリル、トリオクタン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、ジオクタン酸ネオペンチルグリコール、ジカプリン酸ネオペンチルグリコール、ジオクタン酸2-ブチル-2-エチル-1,3-プロパンジオール、ジオレイン酸プロピレングリコール、テトラオクタン酸ペンタエリスリチル、水素添加ロジンペンタエリスリチル、トリエチルヘキサン酸ジトリメチロールプロパン、(イソステアリン酸/セバシン酸)ジトリメチロールプロパン、トリエチルヘキサン酸ペンタエリスリチル、(ヒドロキシステアリン酸/ステアリン酸/ロジン酸)ジペンタエリスリチル、ジイソステアリン酸ジグリセリル、テトライソステアリン酸ポリグリセリル、ノナイソステアリン酸ポリグリセリル-10、デカ(エルカ酸/イソステアリン酸/リシノレイン酸)ポリグリセリル-8、(ヘキシルデカン酸/セバシン酸)ジグリセリルオリゴエステル、ジステアリン酸グリコール(ジステアリン酸エチレングリコール)、ジネオペンタン酸3-メチル-1,5-ペンタンジオール、ジネオペンタン酸2,4-ジエチル-1,5-ペンタンジオール等の多価アルコール脂肪酸エステル類;ジカプリリルエーテル等のアルキルエーテル類;ダイマージリノール酸ジイソプロピル、ダイマージリノール酸ジイソステアリル、ダイマージリノール酸ジ(イソステアリル/フィトステリル)、ダイマージリノール酸(フィトステリル/ベヘニル)、ダイマージリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)、ダイマージリノール酸ダイマージリノレイル、ジイソステアリン酸ダイマージリノレイル、ダイマージリノレイル水添ロジン縮合物、ダイマージリノール酸硬化ヒマシ油、ヒドロキシアルキルダイマージリノレイルエーテル等のダイマー酸若しくはダイマージオールの誘導体;ヤシ油脂肪酸モノエタノールアミド(コカミドMEA)、ヤシ油脂肪酸ジエタノールアミド(コカミドDEA)、ラウリン酸モノエタノールアミド(ラウラミドMEA)、ラウリン酸ジエタノールアミド(ラウラミドDEA)、ラウリン酸モノイソプロパノールアミド(ラウラミドMIPA)、パルミチン酸モノエタノールアミド(パルタミドMEA)、パルミチン酸ジエタノールアミド(パルタミドDEA)、ヤシ油脂肪酸メチルエタノールアミド(コカミドメチルMEA)等の脂肪酸アルカノールアミド類;ジメチコン(ジメチルポリシロキサン)、高重合ジメチコン(高重合ジメチルポリシロキサン)、シクロメチコン(環状ジメチルシロキサン、デカメチルシクロペンタシロキサン)、フェニルトリメチコン、ジフェニルジメチコン、フェニルジメチコン、(アミノエチルアミノプロピルメチコン/ジメチコン)コポリマー、ジメチコノール、ジメチコノールクロスポリマー、シリコーン樹脂、シリコーンゴム、アミノプロピルジメチコン及びアモジメチコン等のアミノ変性シリコーン、カチオン変性シリコーン、ジメチコンコポリオール等のポリエーテル変性シリコーン、ポリグリセリン変性シリコーン、糖変性シリコーン、カルボン酸変性シリコーン、リン酸変性シリコーン、硫酸変性シリコーン、アルキル変性シリコーン、脂肪酸変性シリコーン、アルキルエーテル変性シリコーン、アミノ酸変性シリコーン、ペプチド変性シリコーン、フッ素変性シリコーン、カチオン変性及びポリエーテル変性シリコーン、アミノ変性及びポリエーテル変性シリコーン、アルキル変性及びポリエーテル変性シリコーン、アミドアルキル変性シリコーン、アミノグリコール変性シリコーン、アミノフェニル変性シリコーン、ポリシロキサン・オキシアルキレン共重合体等のシリコーン類;パーフルオロデカン、パーフルオロオクタン、パーフルオロポリエーテル等のフッ素系油剤類が、好ましいものとして挙げられる。 Oil bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, cerakyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, High-grade products such as palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisoheneicosanoic acid, long chain branched fatty acids, dimer acid, hydrogenated dimer acid, etc. Fatty acids and metal soaps such as their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, sodium salts, etc., and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin , α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin, and other hydrocarbons; candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax Waxes such as , ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado Oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat Vegetable oils and fats such as germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef tallow, milk fat, Animal oils and fats such as horse tallow, egg yolk oil, mink oil, and turtle oil; Animal waxes such as spermaceti wax, lanolin, and orange roughy oil; Liquid lanolin, reduced lanolin, adsorption-refined lanolin, acetic acid lanolin, acetic acid liquid lanolin , hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, acetic acid lanolin alcohol, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidyl Sphingophospholipids such as inositol and sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or its salts, phospholipids such as lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soy phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated Phospholipid derivatives such as egg yolk phospholipid; Sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; Sapogenins; Saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, Cholesteryl oleate, N-lauroyl-L-glutamate di(cholesteryl/behenyl/octyldodecyl), N-lauroyl-L-glutamate di(cholesteryl/octyldodecyl), N-lauroyl-L-glutamate di(phytosteryl/behenyl/octyl) dodecyl), di(phytosteryl/octyldodecyl) N-lauroyl-L-glutamate, acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil Sterol esters such as fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid/cholesterol complex, phospholipid/phytosterol complex, etc. lipid complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octoate, hexyldecyl octoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, dicaprylyl carbonate, hexyldecyl dimethyl octanoate, Octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, methylheptyl laurate, methylheptyl myristate, Monoalcohol carboxylic acid esters such as methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate, etc. ; Oxy acid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, γ-erucalactone; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri(caprylic) Acid/capric acid) glyceryl, tri(caprylic acid/capric acid/myristic acid/stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eicosanedioate behenate, trioctanoic acid Trimethylolpropane, trimethylolpropane triisostearate, neopentyl glycol dioctoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctoate, propylene glycol dioleate, pentaeryth tetraoctanoate Lythyl, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearic acid/sebacic acid), pentaerythrityl triethylhexanoate, dipentaerythrityl (hydroxystearic acid/stearic acid/rosin acid), diisostearate Glyceryl, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10, deca (erucic acid/isostearic acid/ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid/sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate) , polyhydric alcohol fatty acid esters such as 3-methyl-1,5-pentanediol dineopentanoate and 2,4-diethyl-1,5-pentanediol dineopentanoate; alkyl ethers such as dicaprylyl ether; dimer dilinoleic acid Diisopropyl, Diisostearyl dimer dilinoleate, Di(isostearyl/phytosteryl) dimer dilinoleate, Dimer dilinoleic acid (phytosteryl/behenyl), Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl), Dimer dilinoleate (isostearyl/phytosteryl) Dimer acid or dimer diol derivatives such as dimer dilinoleyl diisostearate, hydrogenated rosin condensate of dimer dilinoleyl, hydrogenated castor oil of dimer dilinoleic acid, and hydroxyalkyl dimer dilinoleyl ether; Coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (Lauramide MEA), lauric acid diethanolamide (Lauramide DEA), lauric acid monoisopropanolamide (Lauramide MIPA), Fatty acid alkanolamides such as palmitic acid monoethanolamide (palutamide MEA), palmitic acid diethanolamide (palutamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethyl polysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, (aminoethylaminopropyl methicone/dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber , amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphoric acid-modified silicones, sulfuric acid-modified silicones, Alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, amide Silicones such as alkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, and polysiloxane/oxyalkylene copolymers; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are preferred. Can be mentioned.
保湿剤・感触向上剤としては、グリセリン、1,3-ブチレングリコール、プロピレングリコール、3-メチル-1,3-ブタンジオール、1,3-プロパンジオール、2-メチル-1,3-プロパンジオール、トリメチロールプロパン、ペンタエリスリトール、ヘキシレングリコール、ジグリセリン、ポリグリセリン、ジエチレングリコール、ポリエチレングリコール、ジプロピレングリコール、ポリプロピレングリコール、エチレングリコール・プロピレングリコール共重合体等のポリオール類及びその重合体;ジエチレングリコールモノエチルエーテル(エトキシジグリコール)、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、ジエチレングリコールジブチルエーテル等のグリコールアルキルエーテル類;(エイコサン二酸/テトラデカン二酸)ポリグリセリル-10、テトラデカン二酸ポリグリセリル-10、シクロヘキサンジカルボン酸ビスエトキシジグリコール等の水溶性エステル類;ソルビトール、キシリトール、エリスリトール、マンニトール、マルチトール等の糖アルコール類;グルコース、フルクトース、ガラクトース、マンノース、トレオース、キシロース、アラビノース、フコース、リボース、デオキシリボース、マルトース、トレハロース、ラクトース、ラフィノース、グルコン酸、グルクロン酸、シクロデキストリン類(α-、β-、γ-シクロデキストリン、及び、マルトシル化、ヒドロキシアルキル化等の修飾シクロデキストリン)、β-グルカン、キチン、キトサン、ヘパリン及び誘導体、ペクチン、アラビノガラクタン、デキストリン、デキストラン、グリコーゲン、エチルグルコシド、メタクリル酸グルコシルエチル重合物若しくは共重合物等の糖類及びその誘導体類;ヒアルロン酸、ヒアルロン酸ナトリウム;コンドロイチン硫酸ナトリウム;ムコイチン硫酸、カロニン硫酸、ケラト硫酸、デルマタン硫酸;シロキクラゲ抽出物、シロキクラゲ多糖体;イヌリン、レバン等のフルクタン類;フコイダン;チューベロース多糖体、天然由来多糖体;クエン酸、酒石酸、乳酸等の有機酸及びその塩;尿素;2-ピロリドン-5-カルボン酸及びそのナトリウム等の塩;ベタイン(トリメチルグリシン)、プロリン、ヒドロキシプロリン、アルギニン、リジン、セリン、グリシン、アラニン、フェニルアラニン、チロシン、β-アラニン、スレオニン、グルタミン酸、グルタミン、アスパラギン、アスパラギン酸、システイン、シスチン、メチオニン、ロイシン、イソロイシン、バリン、トリプトファン、ヒスチジン、タウリン等のアミノ酸類及びその塩;コラーゲン、魚由来コラーゲン、アテロコラーゲン、ゼラチン、エラスチン、コラーゲン分解ペプチド、加水分解コラーゲン、塩化ヒドロキシプロピルアンモニウム加水分解コラーゲン、エラスチン分解ペプチド、ケラチン分解ペプチド、加水分解ケラチン、コンキオリン分解ペプチド、加水分解コンキオリン、シルク蛋白分解ペプチド、加水分解シルク、ラウロイル加水分解シルクナトリウム、大豆蛋白分解ペプチド、小麦蛋白分解ペプチド、加水分解小麦蛋白、カゼイン分解ペプチド、アシル化ペプチド等の蛋白ペプチド類及びその誘導体;パルミトイルオリゴペプチド、パルミトイルペンタペプチド、パルミトイルテトラペプチド等のアシル化ペプチド類;シリル化ペプチド類;乳酸菌培養液、酵母抽出液、卵殻膜タンパク、牛顎下腺ムチン、ヒポタウリン、ゴマリグナン配糖体、グルタチオン、アルブミン、乳清;塩化コリン、ホスホリルコリン;胎盤抽出液、エアラスチン、コラーゲン、アロエ抽出物、ハマメリス水、ヘチマ水、カモミラエキス、カンゾウエキス、コンフリーエキス、シルクエキス、イザヨイバラエキス、セイヨウノコギリソウエキス、ユーカリエキス、メリロートエキス等の動物・植物抽出成分、天然型セラミド(タイプ1、2、3、4、5、6)、ヒドロキシセラミド、疑似セラミド、スフィンゴ糖脂質、セラミド及び糖セラミド含有エキス等のセラミド類が好ましいものとして挙げられる。 Humectants and feel improvers include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols and their polymers such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol/propylene glycol copolymer; diethylene glycol monoethyl ether Glycol alkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosandioic acid/tetradecanedioic acid) polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, cyclohexanedicarboxylic acid Water-soluble esters such as bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, Trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, Saccharides and their derivatives such as heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymers or copolymers; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate , caronine sulfate, keratosulfate, dermatan sulfate; white fungus extract, white fungus polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, naturally derived polysaccharides; organic acids such as citric acid, tartaric acid, lactic acid, and their salts ; Urea; 2-pyrrolidone-5-carboxylic acid and its salts such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid , glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, and other amino acids and their salts; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydration Degraded collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degraded peptide, keratin-degraded peptide, hydrolyzed keratin, conchiolin-degraded peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptide , protein peptides such as wheat proteolytic peptide, hydrolyzed wheat protein, caseinolytic peptide, acylated peptide, and derivatives thereof; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; Lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract, Hamamelis Water, animal and plant extracts such as loofah water, chamomilla extract, licorice extract, comfrey extract, silk extract, rose thorn extract, yarrow extract, eucalyptus extract, melilot extract, natural ceramides (types 1, 2, 3, 4) , 5, 6), ceramides such as hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide, and sugar ceramide-containing extracts are preferred.
界面活性剤としては、陰イオン性界面活性剤、非イオン性界面活性剤、陽イオン性界面活性剤、両性界面活性剤、高分子界面活性剤等が好ましいものとして挙げられる。界面活性剤のHLBには特に制限はなく、1程度の低いものから20程度の高いものまで使用でき、HLB低いものと高いものを組み合わせることも好ましい。界面活性剤として好ましいものを例示すると、陰イオン性界面活性剤では、ラウリン酸カリウム、ミリスチン酸カリウム等の脂肪酸塩;ラウリル硫酸ナトリウム、ラウリル硫酸トリエタノールアミン、ラウリル硫酸アンモニウム等のアルキル硫酸エステル塩;ラウレス硫酸ナトリウム、ラウレス硫酸トリエタノールアミン等のポリオキシエチレンアルキル硫酸塩;ココイルメチルタウリンナトリウム、ココイルメチルタウリンカリウム、ラウロイルメチルタウリンナトリウム、ミリストイルメチルタウリンナトリウム、ラウロイルメチルアラニンナトリウム、ラウロイルサルコシンナトリウム、ラウロイルサルコシントリエタノールアミン、ラウロイルグルタミン酸メチルアラニンナトリウム等のアシルN-メチルアミノ酸塩;ココイルグルタミン酸ナトリウム、ココイルグルタミン酸トリエタノールアミン、ラウロイルグルタミン酸ナトリウム、ミリストイルグルタミン酸ナトリウム、ステアロイルグルタミン酸ナトリウム、パルミトイルアスパラギン酸ジトリエタノールアミン、ココイルアラニントリエタノールアミン、ジラウロイルグルタミン酸リシンNa等のアシルアミノ酸塩;ラウレス酢酸ナトリウム等のポリオキシエチレンアルキルエーテル酢酸塩;ラウロイルモノエタノールアミドコハク酸ナトリウム等のコハク酸エステル塩;脂肪酸アルカノールアミドエーテルカルボン酸塩;アシル乳酸塩;ポリオキシエチレン脂肪アミン硫酸塩;脂肪酸アルカノールアミド硫酸塩;硬化ヤシ油脂肪酸グリセリン硫酸ナトリウム等の脂肪酸グリセリド硫酸塩;アルキルベンゼンポリオキシエチレン硫酸塩;α-オレフィンスルホン酸ナトリウム等のオレフィンスルホン酸塩;スルホコハク酸ラウリル2ナトリウム、スルホコハク酸ジオクチルナトリウム等のアルキルスルホコハク酸塩;スルホコハク酸ラウレス2ナトリウム、モノラウロイルモノエタノールアミドポリオキシエチレンスルホコハク酸ナトリウム、ラウリルポリプロピレングリコールスルホコハク酸ナトリウム等のアルキルエーテルスルホコハク酸塩;テトラデシルベンゼンスルホン酸ナトリウム、テトラデシルベンゼンスルホン酸トリエタノールアミン等のアルキルベンゼンスルホン酸塩;アルキルナフタレンスルホン酸塩;アルカンスルホン酸塩;α-スルホ脂肪酸メチルエステル塩;アシルイセチオン酸塩;アルキルグリシジルエーテルスルホン酸塩;アルキルスルホ酢酸塩;ラウレスリン酸ナトリウム、ジラウレスリン酸ナトリウム、トリラウレスリン酸ナトリウム、モノオレスリン酸ナトリウム等のアルキルエーテルリン酸エステル塩;ラウリルリン酸カリウム等のアルキルリン酸エステル塩;カゼインナトリウム;アルキルアリールエーテルリン酸塩;脂肪酸アミドエーテルリン酸塩;ホスファチジルグリセロール、ホスファチジルイノシトール、ホスファチジン酸、環状リゾホスファチジン酸またはその塩等のリン脂質類;カルボン酸変性シリコーン、リン酸変性シリコーン、硫酸変性シリコーン等のシリコーン系陰イオン性界面活性剤等;非イオン界面活性剤では、ラウレス(ポリオキシエチレンラウリルエーテル)類、セテス(ポリオキシエチレンセチルエーテル)類、ステアレス(ポリオキシエチレンステアリルエーテル)類、ベヘネス類(ポリオキシエチレンベヘニルエーテル)、イソステアレス(ポリオキシエチレンイソステアリルエーテル)類、オクチルドデセス(ポリオキシエチレンオクチルドデシルエーテル)類等の種々のポリオキシエチレン付加数のポリオキシエチレンアルキルエーテル類;ポリオキシエチレンアルキルフェニルエーテル;ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油モノイソステアレート、ポリオキシエチレン硬化ヒマシ油トリイソステアレート、ポリオキシエチレン硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、ポリオキシエチレン硬化ヒマシ油マレイン酸等のヒマシ油及び硬化ヒマシ油誘導体;ポリオキシエチレンフィトステロール;ポリオキシエチレンコレステロール;ポリオキシエチレンコレスタノール;ポリオキシエチレンラノリン;ポリオキシエチレン還元ラノリン;ポリオキシエチレン・ポリオキシプロピレンセチルエーテル、ポリオキシエチレン・ポリオキシプロピレン2-デシルテトラデシルエーテル、ポリオキシエチレン・ポリオキシプロピレンモノブチルエーテル、ポリオキシエチレン・ポリオキシプロピレン水添ラノリン、ポリオキシエチレン・ポリオキシプロピレングリセリンエーテル等のポリオキシエチレン・ポリオキシプロピレンアルキルエーテル;ポリオキシエチレン・ポリオキシプロピレングリコール;PPG-9ジグリセリル等の(ポリ)グリセリンポリオキシプロピレングリコール;ステアリン酸グリセリル、イソステアリン酸グリセリル、パルミチン酸グリセリル、ミリスチン酸グリセリル、オレイン酸グリセリル、ヤシ油脂肪酸グリセリル、モノ綿実油脂肪酸グリセリン、モノエルカ酸グリセリン、セスキオレイン酸グリセリン、α,α’-オレイン酸ピログルタミン酸グリセリン、モノステアリン酸グリセリンリンゴ酸等のグリセリン脂肪酸部分エステル類;ステアリン酸ポリグリセリル-2、同3、同4、同5、同6、同8、同10、ジステアリン酸ポリグリセリル-6、同10、トリステアリン酸ポリグリセリル-2、デカステアリン酸ポリグリセリル-10、イソステアリン酸ポリグリセリル-2、同3、同4、同5、同6、同8、同10、ジイソステアリン酸ポリグリセリル-2(ジイソステアリン酸ジグリセリル)、同3、同10、トリイソステアリン酸ポリグリセリル-2、テトライソステアリン酸ポリグリセリル-2、デカイソステアリン酸ポリグリセリル-10、オレイン酸ポリグリセリル-2、同3、同4、同5、同6、同8、同10、ジオレイン酸ポリグリセリル-6、トリオレイン酸ポリグリセリル-2、デカオレイン酸ポリグリセリル-10等のポリグリセリン脂肪酸エステル;モノステアリン酸エチレングリコール等のエチレングリコールモノ脂肪酸エステル;モノステアリン酸プロピレングリコール等のプロピレングリコールモノ脂肪酸エステル;ペンタエリスリトール部分脂肪酸エステル;ソルビトール部分脂肪酸エステル;マルチトール部分脂肪酸エステル;マルチトールエーテル;ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンセスキオレエート、ソルビタントリオレエート、ペンタ-2-エチルヘキシル酸ジグリセロールソルビタン、テトラ-2-エチルヘキシル酸ジグリセロールソルビタン等のソルビタン脂肪酸エステル;ショ糖脂肪酸エステル、メチルグルコシド脂肪酸エステル、ウンデシレン酸トレハロース等の糖誘導体部分エステル;カプリリルグルコシド等のアルキルグルコシド;アルキルポリグリコシド;マンノシルエリスリトールリピッド等の糖脂質;ラノリンアルコール;還元ラノリン;ポリオキシエチレンジステアレート、ポリチレングリコールジイソステアレート、ポリオキシエチレンモノオレエート、ポリオキシエチレンジオレエート等のポリオキシエチレン脂肪酸モノ及びジエステル;ポリオキシエチレン・プロピレングリコール脂肪酸エステル;ポリオキシエチレングリセリンモノステアレート、ポリオキシエチレングリセリンモノイソステアレート、ポリオキシエチレングリセリントリイソステアレート等のポリオキシエチレンモノオレエート等のポリオキシエチレングリセリン脂肪酸エステル;ポリオキシエチレンソルビタンモノオレエート、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレンソルビタンモノオレート、ポリオキシエチレンソルビタンテトラオレエート等のポリオキシエチレンソルビタン脂肪酸エステル;ポリオキシエチレンソルビトールモノラウレート、ポリオキシエチレンソルビトールモノオレエート、ポリオキシエチレンソルビトールペンタオレエート、ポリオキシエチレンソルビトールモノステアレート等のポリオキシエチレンソルビトール脂肪酸エステル;ポリオキシエチレンメチルグルコシド脂肪酸エステル;ポリオキシエチレンアルキルエーテル脂肪酸エステル;ポリオキシエチレンソルビトールミツロウ等のポリオキシエチレン動植物油脂類;イソステアリルグリセリルエーテル、キミルアルコール、セラキルアルコール、バチルアルコール等のアルキルグリセリルエーテル類;多価アルコールアルキルエーテル;ポリオキシエチレンアルキルアミン;テトラポリオキシエチレン・テトラポリオキシプロピレン-エチレンジアミン縮合物類;サポニン、ソホロリピッド等の天然系界面活性剤;ポリオキシエチレン脂肪酸アミド;ヤシ油脂肪酸モノエタノールアミド(コカミドMEA)、ヤシ油脂肪酸ジエタノールアミド(コカミドDEA)、ラウリン酸モノエタノールアミド(ラウラミドMEA)、ラウリン酸ジエタノールアミド(ラウラミドDEA)、ラウリン酸モノイソプロパノールアミド(ラウラミドMIPA)、パルミチン酸モノエタノールアミド(パルタミドMEA)、パルミチン酸ジエタノールアミド(パルタミドDEA)、ヤシ油脂肪酸メチルエタノールアミド(コカミドメチルMEA)等の脂肪酸アルカノールアミド類;ラウラミンオキシド、コカミンオキシド、ステアラミンオキシド、ベヘナミンオキシド等のアルキルジメチルアミンオキシド;アルキルエトキシジメチルアミンオキシド;ポリオキシエチレンアルキルメルカプタン;ジメチコンコポリオール等のポリエーテル変性シリコーン、ポリシロキサン・オキシアルキレン共重合体、ポリグリセリン変性シリコーン、糖変性シリコーン等のシリコーン系非イオン性界面活性剤等;陽イオン性界面活性剤では、ベヘントリモニウムクロリド、ステアルトリモニウムクロリド、セトリモニウムクロリド、ラウリルトリモニウムクロリド等のアルキルトリメチルアンモニウムクロリド;ステアリルトリモニウムブロミド等のアルキルトリメチルアンモニウムブロミド;ジステアリルジモニウムクロリド、ジココジモニウムクロリド等のジアルキルジメチルアンモニウムクロリド;ステアラミドプロピルジメチルアミン、ステアラミドエチルジエチルアミン等の脂肪酸アミドアミン及びその塩;ステアロキシプロピルジメチルアミン等のアルキルエーテルアミン及びその塩または四級塩;エチル硫酸長鎖分岐脂肪酸(12~31)アミノプロピルエチルジメチルアンモニウム、エチル硫酸ラノリン脂肪酸アミノプロピルエチルジメチルアンモニウム等の脂肪酸アミド型四級アンモニウム塩;ポリオキシエチレンアルキルアミン及びその塩または四級塩;アルキルアミン塩;脂肪酸アミドグアニジウム塩;アルキルエーテルアミンモニウム塩;アルキルトリアルキレングリコールアンモニウム塩;ベンザルコニウム塩;ベンゼトニウム塩;塩化セチルピリジニウム等のピリジニウム塩;イミダゾリニウム塩;アルキルイソキノリニウム塩;ジアルキルモリホニウム塩;ポリアミン脂肪酸誘導体;アミノプロピルジメチコン及びアモジメチコン等のアミノ変性シリコーン、カチオン変性シリコーン、カチオン変性及びポリエーテル変性シリコーン、アミノ変性及びポリエーテル変性シリコーン等のシリコーン系陽イオン性界面活性剤等;両性界面活性剤では、ラウリルベタイン(ラウリルジメチルアミノ酢酸ベタイン)等のN-アルキル-N,N-ジメチルアミノ酸ベタイン;コカミドプロピルベタイン、ラウラミドプロピルベタイン等の脂肪酸アミドアルキル-N,N-ジメチルアミノ酸ベタイン;ココアンホ酢酸ナトリウム、ラウロアンホ酢酸ナトリウム等のイミダゾリン型ベタイン;アルキルジメチルタウリン等のアルキルスルホベタイン;アルキルジメチルアミノエタノール硫酸エステル等の硫酸型ベタイン;アルキルジメチルアミノエタノールリン酸エステル等のリン酸型ベ
タイン;ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、スフィンゴミエリン等のスフィンゴリン脂質、リゾレシチン、水素添加大豆リン脂質、部分水素添加大豆リン脂質、水素添加卵黄リン脂質、部分水素添加卵黄リン脂質、水酸化レシチン等のリン脂質類;シリコーン系両性界面活性剤等;高分子界面活性剤では、ポリビニルアルコール、アルギン酸ナトリウム、デンプン誘導体、トラガントガム、アクリル酸・メタアクリル酸アルキル共重合体;シリコーン系各種界面活性剤が好ましいものとして挙げられる。
Preferred examples of the surfactant include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymeric surfactants. The HLB of the surfactant is not particularly limited and can range from as low as about 1 to as high as about 20, and it is also preferable to combine surfactants with low and high HLBs. Preferred examples of surfactants include anionic surfactants such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth; Polyoxyethylene alkyl sulfates such as sodium sulfate and triethanolamine laureth sulfate; sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methylalanine, sodium lauroyl sarcosine, and triethanol lauroyl sarcosine. Amine, acyl N-methyl amino acid salts such as sodium lauroyl glutamate methylalanine; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoyl alanine triethanolamine , acylamino acid salts such as dilauroylglutamate lysine Na; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinate ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates ; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Fatty acid glyceride sulfate such as hydrogenated coconut oil fatty acid sodium glycerol sulfate; Alkylbenzene polyoxyethylene sulfate; Olefin sulfonate such as sodium α-olefin sulfonate; Sulfosucci Alkyl sulfosuccinates such as disodium lauryl acid and dioctyl sodium sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, and sodium lauryl polypropylene glycol sulfosuccinate; tetradecyl Alkylbenzenesulfonates such as sodium benzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; Alkyl sulfoacetates; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooleth phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphates Acid acid; fatty acid amide ether phosphate; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or its salts; silicone-based compounds such as carboxylic acid-modified silicone, phosphoric acid-modified silicone, and sulfuric acid-modified silicone Ionic surfactants, etc.; Nonionic surfactants include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenes (polyoxyethylene Polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers such as behenyl ether), isosteareth (polyoxyethylene isostearyl ether), and octyl dodeceth (polyoxyethylene octyl dodecyl ether); polyoxyethylene alkylphenyl ether; Oxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamate monoisostearate diester, polyoxy Castor oil and hydrogenated castor oil derivatives such as ethylene hydrogenated castor oil and maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene/polyoxypropylene Polymers such as cetyl ether, polyoxyethylene/polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene/polyoxypropylene monobutyl ether, polyoxyethylene/polyoxypropylene hydrogenated lanolin, polyoxyethylene/polyoxypropylene glycerin ether, etc. Oxyethylene/polyoxypropylene alkyl ether; polyoxyethylene/polyoxypropylene glycol; (poly)glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, Glyceryl fatty acid partial esters such as glyceryl oleate, glyceryl coconut oil fatty acid, glyceryl monocottonseed oil fatty acid, glyceryl monoerucate, glyceryl sesquioleate, glyceryl pyroglutamate α,α'-oleate, glyceryl monostearate, malic acid; stearic acid Polyglyceryl-2, 3, 4, 5, 6, 8, 10, polyglyceryl-6 distearate, 10, polyglyceryl-2 tristearate, polyglyceryl-10 decastearate, polyglyceryl-2 isostearate , 3, 4, 5, 6, 8, 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate , polyglyceryl decaisostearate-10, polyglyceryl oleate-2, 3, 4, 5, 6, 8, 10, polyglyceryl dioleate-6, polyglyceryl trioleate-2, polyglyceryl decaoleate-10 Polyglycerin fatty acid esters such as; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters; Maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol pent-2-ethylhexylate, sorbitan, tetra Sorbitan fatty acid esters such as diglycerol sorbitan -2-ethylhexylate; partial esters of sugar derivatives such as sucrose fatty acid esters, methyl glucoside fatty acid esters, and trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; mannosylerythritol lipids, etc. glycolipids; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxy Ethylene/propylene glycol fatty acid ester; polyoxyethylene glycerin fatty acid ester such as polyoxyethylene monooleate such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; Polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol Polyoxyethylene sorbitol fatty acid esters such as monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene sorbitol beeswax, etc. polyoxyethylene animal and vegetable oils and fats; alkylglyceryl ethers such as isostearylglyceryl ether, chimyl alcohol, serakyl alcohol, butyl alcohol; polyhydric alcohol alkyl ether; polyoxyethylene alkylamine; tetrapolyoxyethylene/tetrapolyoxy Propylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amide; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (Lauramide MEA), Lauric acid diethanolamide (Lauramide DEA), Lauric acid monoisopropanolamide (Lauramide MIPA), Palmitic acid monoethanolamide (Palutamide MEA), Palmitic acid diethanolamide (Palutamide DEA), Coconut oil fatty acid methylethanolamide ( Fatty acid alkanolamides such as cocamidomethyl MEA); alkyl dimethyl amine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkyl ethoxy dimethyl amine oxides; polyoxyethylene alkyl mercaptans; dimethicone copolyols, etc. Silicone nonionic surfactants such as polyether-modified silicone, polysiloxane/oxyalkylene copolymer, polyglycerin-modified silicone, and sugar-modified silicone; cationic surfactants include behentrimonium chloride and steartrimonium Alkyltrimethylammonium chlorides such as chloride, cetrimonium chloride and lauryltrimonium chloride; Alkyltrimethylammonium bromides such as stearyltrimonium bromide; Dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; stearamidopropyl dimethylamine , fatty acid amide amines and their salts such as stearamide ethyl diethylamine; alkyl ether amines such as stearoxypropyl dimethylamine and their salts or quaternary salts; ethyl sulfate long chain branched fatty acids (12-31) aminopropylethyl dimethyl ammonium, ethyl sulfate Fatty acid amide type quaternary ammonium salts such as lanolin fatty acid aminopropylethyl dimethyl ammonium; polyoxyethylene alkylamine and its salts or quaternary salts; alkyl amine salts; fatty acid amide guanidium salts; alkyl ether amine monoium salts; alkyl trialkylene Glycolammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives; aminopropyl dimethicone, amodimethicone, etc. Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, etc.; Among amphoteric surfactants, lauryl betaine (lauryl dimethylaminoacetic acid betaine) N-alkyl-N,N-dimethylamino acid betaines such as; fatty acid amide alkyl-N,N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; Alkyl sulfobetaines such as alkyl dimethyl taurine; sulfate type betaines such as alkyl dimethylaminoethanol sulfates; phosphate type betaines such as alkyl dimethyl amino ethanol phosphate esters;
Tines; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, hydroxylated lecithin phospholipids such as silicone-based amphoteric surfactants; polymeric surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, gum tragacanth, acrylic acid/alkyl methacrylate copolymers; various silicone-based surfactants. These are listed as preferred.
高分子・増粘剤・ゲル化剤としては、グアーガム、ローカストビーンガム、クィーンスシード、カラギーナン、ガラクタン、アラビアガム、タラガム、タマリンド、ファーセレラン、カラヤガム、トロロアオイ、キャラガム、トラガントガム、ペクチン、ペクチン酸及びナトリウム塩等の塩、アルギン酸及びナトリウム塩等の塩、マンナン;コメ、トウモロコシ、バレイショ、コムギ等のデンプン;キサンタンガム、デキストラン、サクシノグルカン、カードラン、ヒアルロン酸及びその塩、ザンサンガム、プルラン、ジェランガム、キチン、キトサン、寒天、カッソウエキス、コンドロイチン硫酸塩、カゼイン、コラーゲン、ゼラチン、アルブミン;メチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロース及びそのナトリウム等の塩、メチルヒドロキシプロピルセルロース、セルロース硫酸ナトリウム、ジアルキルジメチルアンモニウム硫酸セルロース、結晶セルロース、セルロース末等のセルロース及びその誘導体;可溶性デンプン、カルボキシメチルデンプン、メチルヒドロキシプロピルデンプン、メチルデンプン等のデンプン系高分子、塩化ヒドロキシプロピルトリモニウムデンプン、オクテニルコハク酸トウモロコシデンプンアルミニウム等のデンプン誘導体;アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等アルギン酸誘導体;ポリビニルピドリドン(PVP)、ポリビニルアルコール(PVA)、ビニルピドリドン・ビニルアルコール共重合体、ポリビニルメチルエーテル;ポリエチレングリコール、ポリプロピレングリコール、ポリオキシエチレン・ポリオキシプロピレン共重合体;(メタクリロイルオキシエチルカルボキシベタイン/メタクリル酸アルキル)コポリマー、(アクリレーツ/アクリル酸ステアリル/メタクリル酸エチルアミンオキシド)コポリマー等の両性メタクリル酸エステル共重合体;(ジメチコン/ビニルジメチコン)クロスポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマーAMP;ポリ酢酸ビニル部分けん化物、マレイン酸共重合体;ビニルピロリドン・メタクリル酸ジアルキルアミノアルキル共重合体;アクリル樹脂アルカノールアミン;ポリエステル、水分散性ポリエステル;ポリアクリルアミド;ポリアクリル酸エチル等のポリアクリル酸エステル共重合体、カルボキシビニルポリマー、ポリアクリル酸及びそのナトリウム塩等の塩、アクリル酸・メタアクリル酸エステル共重合体;アクリル酸・メタアクリル酸アルキル共重合体;ポリクオタニウム-10等のカチオン化セルロース、ポリクオタニウム-7等のジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、ポリクオタニウム-22等のアクリル酸・ジアリルジメチルアンモニウムクロリド共重合体、ポリクオタニウム-39等のアクリル酸・ジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、アクリル酸・カチオン化メタアクリル酸エステル共重合体、アクリル酸・カチオン化メタアクリル酸アミド共重合体、ポリクオタニウム-47等のアクリル酸・アクリル酸メチル・塩化メタクリルアミドプロピルトリメチルアンモニウム共重合体、塩化メタクリル酸コリンエステル重合体;カチオン化オリゴ糖、カチオン化デキストラン、グアーヒドロキシプロピルトリモニウムクロリド等のカチオン化多糖類;ポリエチレンイミン;カチオンポリマー;ポリクオタニウム-51等の2-メタクリロイルオキシエチルホスホリルコリンの重合体及びメタクリル酸ブチル共重合体等との共重合体;アクリル樹脂エマルジョン、ポリアクリル酸エチルエマルジョン、ポリアクリルアルキルエステルエマルジョン、ポリ酢酸ビニル樹脂エマルジョン、天然ゴムラテックス、合成ラテックス等の高分子エマルジョン;ニトロセルロース;ポリウレタン類及び各種共重合体;各種シリコーン類;アクリル-シリコーングラフト共重合体等のシリコーン系各種共重合体;各種フッ素系高分子;12-ヒドロキシステアリン酸及びその塩;パルミチン酸デキストリン、ミリスチン酸デキストリン等のデキストリン脂肪酸エステル;無水ケイ酸、煙霧状シリカ(超微粒子無水ケイ酸)、ケイ酸アルミニウムマグネシウム、ケイ酸ナトリウムマグネシウム、金属石鹸、ジアルキルリン酸金属塩、ベントナイト、ヘクトライト、有機変性粘土鉱物、ショ糖脂肪酸エステル、フラクトオリゴ糖脂肪酸エステルが好ましいものとして挙げられる。 Polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, farcellan, gum karaya, trolo mallow, carra gum, gum tragacanth, pectin, pectic acid, and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin , chitosan, agar, Cassow extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyl dimethyl Cellulose and its derivatives such as ammonium cellulose sulfate, crystalline cellulose, cellulose powder; soluble starch, starch polymers such as carboxymethyl starch, methylhydroxypropyl starch, methyl starch, hydroxypropyltrimonium chloride starch, corn starch aluminum octenyl succinate, etc. starch derivatives; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinyl pyridone (PVP), polyvinyl alcohol (PVA), vinyl pyridone/vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene glycol; Polyoxypropylene copolymer; (methacryloyloxyethyl carboxybetaine/alkyl methacrylate) copolymer, amphoteric methacrylate ester copolymer such as (acrylates/stearyl acrylate/ethylamine oxide methacrylate) copolymer; (dimethicone/vinyl dimethicone) cross Polymer, (alkyl acrylate/diacetone acrylamide) copolymer, (alkyl acrylate/diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone/dialkylaminoalkyl methacrylate copolymer; Acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its salt such as sodium salt, acrylic acid/methacrylic acid Ester copolymer; acrylic acid/alkyl methacrylate copolymer; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride/acrylamide copolymer such as polyquaternium-7, acrylic acid/diallyl dimethyl such as polyquaternium-22 Ammonium chloride copolymer, acrylic acid/diallyldimethylammonium chloride/acrylamide copolymer such as polyquaternium-39, acrylic acid/cationized methacrylate ester copolymer, acrylic acid/cationized methacrylic amide copolymer, Acrylic acid/methyl acrylate/methacrylamidopropyltrimethylammonium chloride copolymers such as polyquaternium-47, methacrylic chloride choline ester polymers; cationized polysaccharides such as cationized oligosaccharides, cationized dextran, guar hydroxypropyltrimonium chloride, etc. Saccharides; polyethyleneimine; cationic polymers; copolymers of 2-methacryloyloxyethylphosphorylcholine such as polyquaternium-51 and butyl methacrylate copolymers; acrylic resin emulsions, polyacrylic acid ethyl emulsions, polyacrylic alkyl esters Polymer emulsions such as emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; Nitrocellulose; Polyurethanes and various copolymers; Various silicones; Various silicone copolymers such as acrylic-silicone graft copolymers Various fluorinated polymers; 12-hydroxystearic acid and its salts; Dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine silicic anhydride), aluminum magnesium silicate, silicic acid Preferred examples include sodium magnesium acid, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, and fructooligosaccharide fatty acid ester.
溶剤・噴射剤類としては、エタノール、2-プロパノール(イソプロピルアルコール)、ブタノール、イソブチルアルコール等の低級アルコール類;プロピレングリコール、1,3-ブチレングリコール、ジエチレングリコール、ジプロピレングリコール、イソペンチルジオール等のグリコール類;ジエチレングリコールモノエチルエーテル(エトキシジグリコール)、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、トリエチレングリコールモノエチルエーテル、ジエチレングリコールジエチルエーテル、ジエチレングリコールジブチルエーテル、プロピレングリコールモノエチルエーテル、ジプロピレングリコールモノエチルエーテル等のグリコールエーテル類;エチレングリコールモノエチルエーテルアセテート、ジエチレングリコールモノエチルエーテルアセテート、プロピレングリコールモノエチルエーテルアセテート等のグリコールエーテルエステル類;コハク酸ジエトキシエチル、エチレングリコールジサクシネート等のグリコールエステル類;ベンジルアルコール、ベンジルオキシエタノール、炭酸プロピレン、炭酸ジアルキル、アセトン、酢酸エチル、N-メチルピロリドン;トルエン;フルオロカーボン、次世代フロン;LPG、ジメチルエーテル、炭酸ガス等の噴射剤が好ましいものとして挙げられる。 Examples of solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; Class: Diethylene glycol monoethyl ether (ethoxy diglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl Preferred examples include propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation fluorocarbons; LPG, dimethyl ether, and carbon dioxide gas.
酸化防止剤としては、トコフェロール(ビタミンE)、酢酸トコフェロール等のトコフェロール誘導体;BHT、BHA;没食子酸プロピル等の没食子酸誘導体;ビタミンC(アスコルビン酸)および/またはその誘導体;エリソルビン酸及びその誘導体;亜硫酸ナトリウム等の亜硫酸塩;亜硫酸水素ナトリウム等の亜硫酸水素塩;チオ硫酸ナトリウム等のチオ硫酸塩;メタ亜硫酸水素塩;チオタウリン、ヒポタウリン;チオグリセロール、チオ尿素、チオグリコール酸、システイン塩酸塩が好ましいものとして挙げられる。還元剤としては、チオグリコール酸、システイン、システアミン等が好ましいものとして挙げられる。酸化剤としては、過酸化水素水、過硫酸アンモニウム、臭素酸ナトリウム、過炭酸等が好ましいものとして挙げられる。 As antioxidants, tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and/or its derivatives; erythorbic acid and its derivatives; Sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine hydrochloride are preferred. It is mentioned as. Preferred examples of the reducing agent include thioglycolic acid, cysteine, and cysteamine. Preferred examples of the oxidizing agent include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.
抗菌剤又は防腐剤としては、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン等のパラベン(ヒドロキシ安息香酸エステル)類;フェノキシエタノール;1,2-ペンタンジオール、1,2-ヘキサンジオール、1,2-オクタンジオール等の1,2-アルカンジオール類;2-エチルヘキシルグリセリルエーテル(エチルヘキシルグリセリン)等のアルキルグリセリルエーテル類;サリチル酸;安息香酸ナトリウム;メチルクロロイソチアゾリノン、メチルイソチアゾリノン等のイソチアゾリンオン誘導体;イミダゾリニウムウレア;デヒドロ酢酸及びその塩;フェノール類;トリクロサン等のハロゲン化ビスフェノール類、酸アミド類、四級アンモニウム塩類;トリクロロカルバニド、ジンクピリチオン、塩化ベンザルコニウム、塩化ベンゼトニウム、ソルビン酸、クロルヘキシジン、グルコン酸クロルヘキシジン、ハロカルバン、ヘキサクロロフェン、ヒノキチオール;フェノール、イソプロピルフェノール、クレゾール、チモール、パラクロロフェノール、フェニルフェノール、フェニルフェノールナトリウム等のその他フェノール類;フェニルエチルアルコール、感光素類、抗菌性ゼオライト、銀イオンが好ましいものとして挙げられるが、防腐を目的とした抗菌剤又は防腐剤として用いる場合は、化粧料又は皮膚外用剤の安全性の観点から、フェノキシエタノール;1,2-ペンタンジオール、1,2-ヘキサンジオール、1,2-オクタンジオール等の1,2-アルカンジオール類;2-エチルヘキシルグリセリルエーテル等のアルキルグリセリルエーテル類を用いることが、より好ましい。 Antibacterial agents or preservatives include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diols; alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazo Linium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, glucone Other phenols such as acid chlorhexidine, halocarban, hexachlorophene, hinokitiol; phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, phenylphenol sodium; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ions However, when used as an antibacterial agent or preservative for the purpose of preservation, phenoxyethanol; 1,2-pentanediol, 1,2-hexane It is more preferable to use diols, 1,2-alkanediols such as 1,2-octanediol; and alkylglyceryl ethers such as 2-ethylhexylglyceryl ether.
キレート剤としては、EDTA、EDTA2Na、EDTA3Na、EDTA4Na等のエデト酸塩(エチレンジアミン四酢酸塩);HEDTA3Na等のヒドロキシエチルエチレンジアミン三酢酸塩;ペンテト酸塩(ジエチレントリアミン五酢酸塩);フィチン酸;エチドロン酸等のホスホン酸及びそのナトリウム塩等の塩類;シュウ酸ナトリウム;ポリアスパラギン酸、ポリグルタミン酸等のポリポリアミノ酸類;ポリリン酸ナトリウム、メタリン酸ナトリウム、リン酸;クエン酸ナトリウム、クエン酸、アラニン、ジヒドロキシエチルグリシン、グルコン酸、アスコルビン酸、コハク酸、酒石酸が好ましいものとして挙げられる。pH調整剤・酸・アルカリとしては、クエン酸、クエン酸ナトリウム、乳酸、乳酸ナトリウム、グリコール酸、コハク酸、酢酸、酢酸ナトリウム、リンゴ酸、酒石酸、フマル酸、リン酸、塩酸、硫酸、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、イソプロパノールアミン、トリイソプロパノールアミン、2-アミノ-2-メチル-1,3ープロパンジオール、2-アミノ-2-ヒドロキシメチル-1,3ープロパンジオール、アルギニン、水酸化ナトリウム、水酸化カリウム、アンモニア水、炭酸グアニジン、炭酸アンモニウムが好ましいものとして挙げられる。 As chelating agents, edetate salts (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, EDTA4Na; hydroxyethylethylenediamine triacetate such as HEDTA3Na; pentetate salts (diethylenetriaminepentaacetate); phytic acid; etidronic acid, etc. Salts such as phosphonic acid and its sodium salt; Sodium oxalate; Polypolyamino acids such as polyaspartic acid and polyglutamic acid; Sodium polyphosphate, sodium metaphosphate, phosphoric acid; Sodium citrate, citric acid, alanine, dihydroxyethylglycine Preferred examples include , gluconic acid, ascorbic acid, succinic acid, and tartaric acid. Examples of pH adjusters/acids/alkali include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, and monoethanol. Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Preferred examples include sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.
粉体類としては、マイカ、タルク、カオリン、セリサイト、モンモリロナイト、カオリナイト、雲母、白雲母、金雲母、合成雲母、紅雲母、黒雲母、パーミキュライト、炭酸マグネシウム、炭酸カルシウム、ケイ酸アルミニウム、ケイ酸バリウム、ケイ酸カルシウム、ケイ酸マグネシウム、ケイ酸ストロンチウム、タングステン酸金属塩、マグネシウム、ゼオライト、硫酸バリウム、焼成硫酸カルシウム、リン酸カルシウム、弗素アパタイト、ヒドロキシアパタイト、セラミックパウダー、ベントナイト、スメクタイト、粘土、泥、金属石鹸(例えば、ミリスチン酸亜鉛、パルミチン酸カルシウム、ステアリン酸アルミニウム)、炭酸カルシウム、ベンガラ、黄酸化鉄、黒酸化鉄、群青、紺青、カーボンブラック、酸化チタン、微粒子及び超微粒子酸化チタン、酸化亜鉛、微粒子及び超微粒子酸化亜鉛、アルミナ、シリカ、煙霧状シリカ(超微粒子無水ケイ酸)、雲母チタン、魚鱗箔、窒化ホウ素、ホトクロミック顔料、合成フッ素金雲母、微粒子複合粉体、金、アルミニウム等の各種の大きさ・形状の無機粉体、及び、これらをハイドロジェンシリコーン、環状ハイドロジェンシリコーン等のシリコーン若しくはその他のシラン若しくはチタンカップリング剤等の各種表面処理剤で処理を行って疎水化若しくは親水化した粉体等の無機粉体;デンプン、セルロース、ナイロンパウダー、ポリエチレン末、ポリメタクリル酸メチル末、ポリスチレン末、スチレンとアクリル酸の共重合体樹脂粉末、ポリエステル末、ベンゾグアナミン樹脂粉末、ポリエチレンテレフタレート・ポリメチルメタクリレート積層末、ポリエチレンテレフタレート・アルミニウム・エポキシ積層末等、ウレタン粉末、シリコーン粉末、テフロン(登録商標)粉末等の各種の大きさ・形状の有機系粉体及び表面処理粉体、有機無機複合粉体が好ましいものとして挙げられる。無機塩類としては、食塩、並塩、岩塩、海塩、天然塩等の塩化ナトリウム含有塩類;塩化カリウム、塩化アルミニウム、塩化カルシウム、塩化マグネシウム、にがり、塩化亜鉛、塩化アンモニウム;硫酸ナトリウム、硫酸アルミニウム、硫酸アルミニウム・カリウム(ミョウバン)、硫酸アルミニウム・アンモニウム、硫酸バリウム、硫酸カルシウム、硫酸カリウム、硫酸マグネシウム、硫酸亜鉛、硫酸鉄、硫酸銅;リン酸1Na・2Na・3Na等のリン酸ナトリウム類、リン酸カリウム類、リン酸カルシウム類、リン酸マグネシウム類が好ましいものとして挙げられる。 Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, rhodochite, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica. Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metallic soaps (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, deep blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide , fine and ultrafine particles of zinc oxide, alumina, silica, fumed silica (ultrafine silicic acid anhydride), mica titanium, fish scale foil, boron nitride, photochromic pigments, synthetic fluorine phlogopite, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with silicone such as hydrogen silicone, cyclic hydrogen silicone, other silanes, or various surface treatment agents such as titanium coupling agents to make them hydrophobic or Inorganic powders such as hydrophilic powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate・Organic powders of various sizes and shapes such as polymethyl methacrylate laminated powder, polyethylene terephthalate/aluminum/epoxy laminated powder, urethane powder, silicone powder, Teflon (registered trademark) powder, etc., and surface-treated powder, organic and inorganic. Composite powder is preferred. Inorganic salts include sodium chloride-containing salts such as common salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum/potassium sulfate (alum), aluminum/ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na, and 3Na phosphate, phosphoric acid Preferred examples include potassium, calcium phosphates, and magnesium phosphates.
紫外線吸収剤としては、パラアミノ安息香酸、パラアミノ安息香酸モノグリセリンエステル、N,N-ジプロポキシパラアミノ安息香酸エチルエステル、N,N-ジエトキシパラアミノ安息香酸エチルエステル、N,N-ジメチルパラアミノ安息香酸エチルエステル、N,N-ジメチルパラアミノ安息香酸ブチルエステル、N,N-ジメチルパラアミノ安息香酸エチルエステル等の安息香酸系紫外線吸収剤;ホモメンチル-N-アセチルアントラニレート等のアントラニル酸系紫外線吸収剤;サリチル酸及びそのナトリウム塩、アミルサリシレート、メンチルサリシレート、ホモメンチルサリシレート、オクチルサリシレート、フェニルサリシレート、ベンジルサリシレート、p-イソプロパノールフェニルサリシレート等のサリチル酸系紫外線吸収剤;オクチルシンナメート、エチル-4-イソプロピルシンナメート、メチル-2,5-ジイソプロピルシンナメート、エチル-2,4-ジイソプロピルシンナメート、メチル-2,4-ジイソプロピルシンナメート、プロピル-p-メトキシシンナメート、イソプロピル-p-メトキシシンナメート、イソアミル-p-メトキシシンナメート、2-エチルヘキシルp-メトキシシンナメート(パラメトキシケイヒ酸オクチル)、2-エトキシエチル-p-メトキシシンナメート(シノキサート)、シクロヘキシル-p-メトキシシンナメート、エチル-α-シアノ-β-フェニルシンナメート、2-エチルヘキシルα-シアノ-β-フェニルシンナメート(オクトクリン)、グリセリルモノ-2-エチルヘキサノイル-ジパラメトキシシンナメート、フェルラ酸及びその誘導体等の桂皮酸系紫外線吸収剤;2,4-ジヒドロキシベンゾフェノン、2,2’-ジヒドロキシ-4-メトキシベンゾフェノン、2,2’-ジヒドロキシ-4,4’-ジメトキシベンゾフェノン、2,2’,4,4’-テトラヒドロキシベンゾフェノン、2-ヒドロキシ-4-メトキシベンゾフェノン(オキシベンゾン-3)、2-ヒドロキシ-4-メトキシ-4’-メチルベンゾフェノン、2-ヒドロキシ-4-メトキシベンゾフェノン-5-スルホン酸塩、4-フェニルベンゾフェノン、2-エチルヘキシル-4’-フェニル-ベンゾフェノン-2-カルボキシレート、2-ヒドロキシ-4-n-オクトキシベンゾフェノン、4-ヒドロキシ-3-カルボキシベンゾフェノン等のベンゾフェノン系紫外線吸収剤;3-(4’-メチルベンジリデン)-d,l-カンファー、3-ベンジリデン-d,l-カンファー;2-フェニル-5-メチルベンゾキサゾール;2,2’-ヒドロキシ-5-メチルフェニルベンゾトリアゾール;2-(2’-ヒドロキシ-5’-t-オクチルフェニル)ベンゾトリアゾール;2-(2’-ヒドロキシ-5’-メチルフェニルベンゾトリアゾール;ジベンザラジン;ジアニソイルメタン;5-(3,3-ジメチル-2-ノルボルニリデン)-3-ペンタン-2-オン;4-t-ブチルメトキシジベンゾイルメタン等のジベンゾイルメタン誘導体;オクチルトリアゾン;ウロカニン酸及びウロカニン酸エチル等のウロカニン酸誘導体;2-(2'-ヒドロキシ-5'-メチルフェニル)ベンゾトリアゾール、1-(3,4-ジメトキシフェニル)-4,4-ジメチル-1,3-ペンタンジオン、ジメトキシベンジリデンジオキソイミダゾリジンプロピオン酸2-エチルヘキシル等のヒダントイン誘導体、フェニルベンズイミダソゾールスルホン酸、テレフタリリデンジカンフルスルホン酸、ドロメトリゾールトリシロキサン、アントラニル酸メチル、ルチン及びその誘導体、オリザノール及びその誘導体が好ましいものとして挙げられる。 As ultraviolet absorbers, para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, N,N-diethoxypara-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid ethyl ester. Benzoic acid-based UV absorbers such as ester, N,N-dimethylpara-aminobenzoic acid butyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester; Anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid Salicylic acid UV absorbers such as and its sodium salts, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl -2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxy Cinnamate, 2-ethylhexyl p-methoxycinnamate (octyl para-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Cinnamic acid UV absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and its derivatives; 2, 4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' - Benzophenone UV absorbers such as phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d, l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'- t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentane-2- dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyltriazole; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole , 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidene dioxoimidazolidine, hydantoin derivatives such as 2-ethylhexyl propionate, phenylbenzimidasozole sulfonic acid, Preferred examples include phthalylidene dicanfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.
ビタミン類及びその誘導体類としては、レチノール、酢酸レチノール、パルミチン酸レチノール等のビタミンA類;チアミン塩酸塩、チアミン硫酸塩、リボフラビン、酢酸リボフラビン、塩酸ピリドキシン、ピリドキシンジオクタノエート、ピリドキシンジパルミテート、フラビンアデニンジヌクレオチド、シアノコバラミン、葉酸類、ニコチン酸アミド・ニコチン酸ベンジル等のニコチン酸類、コリン類等のビタミンB群類;アスコルビン酸及びそのナトリウム等の塩等のビタミンC類;ビタミンD;α、β、γ、δ-トコフェロール等のビタミンE類;パントテン酸、ビオチン等のその他ビタミン類;アスコルビン酸リン酸エステルナトリウム塩及びアスコルビン酸リン酸エステルマグネシウム塩等のアスコルビン酸リン酸エステル塩、アスコルビン酸テトライソパルミチン酸エステル・ステアリン酸アスコルビル・パルミチン酸アスコルビル・ジパルミチン酸アスコルビル等のアスコルビン酸脂肪酸エステル、アスコルビン酸エチルエーテル等のアスコルビン酸アルキルエーテル、アスコルビン酸-2-グルコシド等のアスコルビン酸グルコシド及びその脂肪酸エステル、リン酸トコフェリルアスコルビル等のアスコルビン酸誘導体;ニコチン酸トコフェロール、酢酸トコフェロール、リノール酸トコフェロール、フェルラ酸トコフェロール、トコフェロールリン酸エステル等のトコフェロール誘導体等のビタミン誘導体、トコトリエノール、その他各種ビタミン誘導体類が好ましいものとして挙げられる。 Examples of vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its salts such as sodium; vitamin D; α, Vitamin E such as β, γ, δ-tocopherol; Other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate salts such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, ascorbic acid tetra Ascorbic acid fatty acid esters such as isopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside, and their fatty acid esters , ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol derivatives such as tocopherol nicotinate, tocopheryl acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate, tocotrienols, and other various vitamin derivatives are preferred. It is mentioned as.
消炎剤・抗炎症剤としては、グリチルリチン酸及びその誘導体、グリチルレチン酸誘導体、サリチル酸誘導体、ヒノキチオール、グアイアズレン、アラントイン、インドメタシン、酸化亜鉛、酢酸ヒドロコーチゾン、プレドニゾン、塩酸ジフェドラミン、マレイン酸クロルフェニラミン;桃葉エキス、蓬葉エキス等の植物エキスが好ましいものとして挙げられる。育毛用薬剤・血行促進剤・刺激剤としては、センブリエキス、トウガラシチンキ、ショウキョウチンキ、ショウキョウエキス、カンタリスチンキ等の植物エキス・チンキ類;カプサイシン、ノニル酸ワレニルアミド、ジンゲロン、イクタモール、タンニン酸、ボルネオール、シクランデレート、シンナリジン、トラゾリン、アセチルコリン、ベラパミル、セファランチン、γ-オリザノール、セファランチン、ビタミンE及びニコチン酸トコフェロール・酢酸トコフェロール等の誘導体、γ-オリザノール、ニコチン酸及びニコチン酸アミド・ニコチン酸ベンジルエステル・イノシトールヘキサニコチネート、ニコチンアルコール等の誘導体、アラントイン、感光素301、感光素401、塩化カプロニウム、ペンタデカン酸モノグリセリド、フラバノノール誘導体、スチグマステロール又はスチグマスタノール及びその配糖体、ミノキシジルが好ましいものとして挙げられる。ホルモン類としては、エストラジオール、エストロン、エチニルエストラジオール、コルチゾン、ヒドロコルチゾン、プレドニゾン等が好ましいものとして挙げられる。抗しわ剤、抗老化剤、ひきしめ剤、冷感剤、温感剤、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤等のその他の薬効剤としては、レチノール類、レチノイン酸類、レチノイン酸トコフェリル;乳酸、グリコール酸、グルコン酸、フルーツ酸、サリチル酸及びその配糖体・エステル化物等の誘導体、ヒドロキシカプリン酸、長鎖α-ヒドロキシ脂肪酸、長鎖α-ヒドロキシ脂肪酸コレステリル等のα-又はβ-ヒドロキシ酸類及びその誘導体類;γ-アミノ酪酸、γ-アミノ-β-ヒドロキシ酪酸;カルニチン;カルノシン;クレアチン;セラミド類、スフィンゴシン類;カフェイン、キサンチン等及びその誘導体;コエンザイムQ10、カロチン、リコピン、アスタキサンチン、ルテイン、α-リポ酸、白金ナノコロイド、フラーレン類等の抗酸化・活性酸素消去剤;カテキン類;ケルセチン等のフラボン類;イソフラボン類;没食子酸及びエステル糖誘導体;タンニン、セサミン、プロトアントシアニジン、クロロゲン酸、リンゴポリフェノール等のポリフェノール類;ルチン及び配糖体等の誘導体;ヘスペリジン及び配糖体等の誘導体;リグナン配糖体;グラブリジン、グラブレン、リクイリチン、イソリクイリチン等のカンゾウエキス関連物質;ラクトフェリン;ショウガオール、ジンゲロール;メントール、カンファー、セドロール等の香料物質及びその誘導体;カプサイシン、バニリン等及び誘導体;ジエチルトルアミド等の昆虫忌避剤;生理活性物質とシクロデキストリン類との複合体が好ましいものとして挙げられる。 Anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, dipedramine hydrochloride, chlorpheniramine maleate; peach leaf extract. Preferred examples include plant extracts such as , mugwort leaf extract and the like. Hair growth drugs, blood circulation promoters, and stimulants include plant extracts and tinctures such as Aspergillus japonica extract, capsicum tincture, ginger tincture, ginger extract, and cantharis tincture; capsaicin, nonylic acid valenylamide, zingerone, ictamol, and tannic acid. , borneol, cyclanderate, cinnarizine, tolazoline, acetylcholine, verapamil, cephalanthine, γ-oryzanol, cephalanthine, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid and nicotinamide and benzyl nicotinate. Ester inositol hexanicotinate, derivatives such as nicotine alcohol, allantoin, photosensor 301, photosensor 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and its glycosides, and minoxidil are preferred. It is mentioned as. Preferred examples of hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, and prednisone. Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoters, irritation relievers, analgesics, and cell activators include retinols, retinoic acids, and retinoin. Tocopheryl acid: derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and its glycosides and esters, hydroxycapric acid, long chain α-hydroxy fatty acids, α- or long chain α-hydroxy fatty acids such as cholesteryl β-hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosine; caffeine, xanthine, etc. and their derivatives; coenzyme Q10, carotene, lycopene , astaxanthin, lutein, α-lipoic acid, nanocolloidal platinum, fullerenes and other antioxidants and active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; tannins, sesamin, proto Polyphenols such as anthocyanidins, chlorogenic acid, and apple polyphenols; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; substances related to licorice extract such as glabridin, glabrene, liquiritin, and isoliquiritin; lactoferrin ; gingerol, gingerol; fragrance substances and their derivatives such as menthol, camphor, cedrol; capsaicin, vanillin, etc. and derivatives; insect repellents such as diethyltoluamide; complexes of physiologically active substances and cyclodextrins are preferred. Can be mentioned.
植物・動物・微生物エキス類としては、アイリスエキス、アシタバエキス、アスナロエキス、アスパラガスエキス、アボガドエキス、アマチャエキス、アーモンドエキス、アルテアエキス、アルニカエキス、アロエエキス、アンズエキス、アンズ核エキス、イチョウエキス、インチコウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、ウワウルシエキス、エイジツエキス、エチナシ葉エキス、エンメイソウエキス、オウゴンエキス、オウバクエキス、オウレンエキス、オオムギエキス、オタネニンジンエキス、オトギリソウエキス、オドリコソウエキス、オノニスエキス、オランダカラシエキス、オレンジエキス、海水乾燥物、海藻エキス、カキ葉エキス、カキョクエキス、加水分解エラスチン、加水分解コムギ末、加水分解シルク、カッコンエキス、カモミラエキス、油溶性カモミラエキス、カロットエキス、カワラヨモギエキス、カラスムギエキス、カルカデエキス、カンゾウエキス、油溶性カンゾウエキス、キウイエキス、キオウエキス、キクラゲエキス、キナエキス、キューカンバーエキス、キリ葉エキス、グアノシン、グアバエキス、クジンエキス、クチナシエキス、クマザサエキス、クララエキス、クルミエキス、クリエキス、グレープフルーツエキス、クレマティスエキス、黒米エキス、黒砂糖抽出物、黒酢、クロレラエキス、クワエキス、ゲンチアナエキス、ゲンノショウコエキス、紅茶エキス、酵母エキス、コウボクエキス、コーヒーエキス、ゴボウエキス、コメエキス、コメ発酵エキス、コメヌカ発酵エキス、コメ胚芽油、コンフリーエキス、コラーゲン、コケモモエキス、サイシンエキス、サイコエキス、サイタイ抽出液、サフランエキス、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、サンシャエキス、サンショウエキス、シイタケエキス、ジオウエキス、シコンエキス、シソエキス、シナノキエキス、シモツケソウエキス、ジャトバエキス、シャクヤクエキス、ショウキュウエキス、ショウブ根エキス、シラカバエキス、白キクラゲエキス、スギナエキス、ステビアエキス、ステビア発酵物、西河柳エキス、セイヨウキズタエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、セージエキス、ゼニアオイエキス、センキュウエキス、センブリエキス、ソウハクヒエキス、ダイオウエキス、ダイズエキス、タイソウエキス、タイムエキス、タンポポエキス、地衣類エキス、茶エキス、チョウジエキス、チガヤエキス、チンピエキス、ティートリー油、甜茶エキス、トウガラシエキス、トウキエキス、トウキンセンカエキス、トウニンエキス、トウヒエキス、ドクダミエキス、トマトエキス、納豆エキス、ニンジンエキス、ニンニクエキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、ハスエキス、パセリエキス、バーチエキス、蜂蜜、ハマメリスエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、ヒノキエキス、ビフィズス菌エキス、ビワエキス、フキタンポポエキス、フキノトウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、ブドウ種子エキス、プロポリス、ヘチマエキス、ベニバナエキス、ペパーミントエキス、ボダイジュエキス、ボタンエキス、ホップエキス、マイカイカエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、メリッサエキス、モズクエキス、モモエキス、ヤグルマギクエキス、ユーカリエキス、ユキノシタエキス、ユズエキス、ユリエキス、ヨクイニンエキス、ヨモギエキス、ラベンダーエキス、緑茶エキス、卵殻膜エキス、リンゴエキス、ルイボス茶エキス、レイシエキス、レタスエキス、レモンエキス、レンギョウエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス、ローヤルゼリーエキス、ワレモコウエキス等のエキスが好ましいものとして挙げられる。 Plant, animal, and microorganism extracts include iris extract, Ashitaba extract, Asunaro extract, asparagus extract, avocado extract, amacha extract, almond extract, althea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, and ginkgo extract. , fenugreek extract, fennel extract, turmeric extract, oolong tea extract, fennel extract, turmeric extract, echidna leaf extract, japonica extract, scutellariae extract, scutellariae extract, scutellariae extract, barley extract, panax ginseng extract, hypericum extract, deadlock root extract, ononis extract , mustard extract, orange extract, dried seawater, seaweed extract, persimmon leaf extract, persimmon extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cuckoo extract, chamomilla extract, oil-soluble chamomilla extract, carot extract, mugwort Extract, oat extract, karkade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiosk extract, wood ear extract, cinchona extract, cucumber extract, tungsten leaf extract, guanosine, guava extract, kujin extract, gardenia extract, kumata extract, clara extract, walnut Extract, Chestnut extract, Grapefruit extract, Clematis extract, Black rice extract, Brown sugar extract, Black vinegar, Chlorella extract, Mulberry extract, Gentiana extract, Gennoshouko extract, Black tea extract, Yeast extract, Kouboku extract, Coffee extract, Burdock extract, Rice extract, Rice Fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, collagen, lingonberry extract, saicin extract, saicin extract, rhinoceros extract, saffron extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, sasanya extract, sasanya extract Extract, shiitake extract, rhododendron extract, perilla extract, perilla extract, linden extract, meadow extract, jatoba extract, peony extract, calamus extract, calamus root extract, white birch extract, white wood ear extract, horsetail extract, stevia extract, stevia fermented product, sahe willow extract, Hawthorn Extract, Hawthorn Extract, Sambucus Extract, Yarrow Extract, Mentha Extract, Sage Extract, Mallow Extract, Nebula Extract, Japanese Cucumber Extract, Cucumber Extract, Rhubarb Extract, Soybean Extract, Taishu Extract, Thyme Extract, Dandelion Extract, Ground Clothes extract, tea extract, clove extract, Chigaya extract, chimpi extract, tea tree oil, sweet tea extract, capsicum extract, Japanese ginger extract, Calendula extract, Tonin extract, Spruce extract, Hokutama extract, tomato extract, natto extract, carrot extract, garlic extract, Novara extract , hibiscus extract, bacterium extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietaria extract, hikiokoshi extract, bisabolol, cypress extract, bifidobacterium extract, loquat extract, coltsfoot extract, coltsfoot extract, butterbur extract, butcher Bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, bodega extract, button extract, hop extract, mica extract, pine extract, horse chestnut extract, skunk cabbage extract, Sapindium extract, Melissa extract, Mozuku extract , peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, reishi extract, lettuce extract, lemon extract, forsythia extract , Astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and silver leaf extract are preferred.
鎮痒剤としては、塩酸ジフェンヒドラミン、マレイン酸クロルフェニラミン、カンファー、サブスタンス-P阻害剤等を例示することができる。角質剥離・溶解剤としては、サリチル酸、イオウ、レゾルシン、硫化セレン、ピリドキシン等を例示することができる。制汗剤としては、クロルヒドロキシアルミニウム、塩化アルミニウム、酸化亜鉛、パラフェノールスルホン酸亜鉛等を例示することができる。清涼剤としては、メントール、サリチル酸メチル等を例示することができる。収れん剤としては、クエン酸、酒石酸、乳酸、硫酸アルミニウム・カリウム、タンニン酸等を例示することができる。酵素類としては、スーパーオキサイドディスムターゼ、カタラーゼ、塩化リゾチーム、リパーゼ、パパイン、パンクレアチン、プロテアーゼ等を例示することができる。核酸類としては、リボ核酸及びその塩、デオキシリボ核酸及びその塩、アデノシン三リン酸二ナトリウムが好ましいものとして挙げられる。 Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance-P inhibitors. Examples of exfoliating and dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, and pyridoxine. Examples of antiperspirants include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of the refreshing agent include menthol, methyl salicylate, and the like. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum/potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Preferred examples of the nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and disodium adenosine triphosphate.
香料としては、アセチルセドレン、アミルシンナムアルデヒド、アリルアミルグリコレート、β-イオノン、イソイースーパー、イソブチルキノリン、イリス油、イロン、インドール、イランイラン油、ウンデカナール、ウンデセナール、γ-ウンデカラクトン、エストラゴール、オイゲノール、オークモス、オポポナックスレジノイド、オレンジ油、オイゲノール、オーランチオール、ガラクソリッド、カルバクロール、L-カルボン、カンファー、キャノン、キャロットシード油、クローブ油、ケイヒ酸メチル、ゲラニオール、ゲラニルニトリル、酢酸イソボルニル、酢酸ゲラニル、酢酸ジメチルベンジルカルビニル、酢酸スチラリル、酢酸セドリル、酢酸テレピネル、酢酸p-t-ブチルシクロヘキシル、酢酸ベチベリル、酢酸ベンジル、酢酸リナリル、サリチル酸イソペンチル、サリチル酸ベンジル、サンダルウッド油、サンタロール、シクラメンアルデヒド、シクロペンタデカノリド、ジヒドロジャスモン酸メチル、ジヒドロミルセノール、ジャスミンアブソリュート、ジャスミンラクトン、cis-ジャスモン、シトラール、シトロネノール、シトロネラール、シナモンバーク油、1,8-シネオール、シンナムアルデヒド、スチラックスレジノイド、セダーウッド油、セドレン、セドロール、セロリシード油、タイム油、ダマスコン、ダマセノン、チモール、チュベローズアブソリュート、デカナール、デカラクトン、テルピネオール、γ-テルピネン、トリプラール、ネロール、ノナナール、2,6-ノナジエノール、ノナラクトン、パチョリアルコール、バニラアブソリュート、バニリン、バジル油、パチョリ油、ヒドロキシシトロネラール、α-ピネン、ピペリトン、フェネチルアルコール、フェニルアセトアルデヒド、プチグレン油、ヘキシルシンナムアルデヒド、cis-3-ヘキセノール、ペルーバルサム、ベチバー油、ベチベロール、ペパーミント油、ペパー油、ヘリオトロピン、ベルガモット油、ベンジルベンゾエート、ボルネオール、ミルレジノイド、ムスクケトン、メチルノニルアセトアルデヒド、γ-メチルヨノン、メントール、L-メントール、L-メントン、ユーカリ油、β-ヨノン、ライム油、ラベンダー油、D-リモネン、リナロール、リラール、リリアール、レモン油、ローズアブソリュート、ローズオキシド、ローズ油、ローズマリー油、各種精油等の合成香料及び天然香料並びに各種調合香料が好ましいものとして挙げられる。 Fragrances include acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoee super, isobutylquinoline, iris oil, irone, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galaxolide, carvacrol, L-carvone, camphor, canon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranylnitrile , isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styralyl acetate, cedryl acetate, terepinel acetate, p-t-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, Cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromircenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax Resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli Alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, Peruvian balsam, vetiver oil, vetiverol , peppermint oil, pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil , lavender oil, D-limonene, linalool, liral, lireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and other synthetic and natural fragrances and various blended fragrances are preferred.
色素・着色剤・染料・顔料としては、褐色201号、黒色401号、紫色201号、紫色401号、青色1号、青色2号、青色201号、青色202号、青色203号、青色204号、青色205号、青色403号、青色404号、緑色201号、緑色202号、緑色204号、緑色205号、緑色3号、緑色401号、緑色402号、赤色102号、赤色104-1号、赤色105-1号、赤色106号、赤色2号、赤色201号、赤色202号、赤色203号、赤色204号、赤色205号、赤色206号、赤色207号、赤色208号、赤色213号、赤色214号、赤色215号、赤色218号、赤色219号、赤色220号、赤色221号、赤色223号、赤色225号、赤色226号、赤色227号、赤色228号、赤色230-1号、赤色230-2号、赤色231号、赤色232号、赤色3号、赤色401号、赤色404号、赤色405号、赤色501号、赤色502号、赤色503号、赤色504号、赤色505号、赤色506号、橙色201号、橙色203号、橙色204号、橙色205号、橙色206号、橙色207号、橙色401号、橙色402号、橙色403号、黄色201号、黄色202-1号、黄色202-2号、黄色203号、黄色204号、黄色205号、黄色4号、黄色401号、黄色402号、黄色403-1号、黄色404号、黄色405号、黄色406号、黄色407号、黄色5号等の法定色素;Acid Red 14等のその他酸性染料;Arianor Sienna Brown、Arianor Madder Red、Arianor Steel Blue、Arianor Straw Yellow等の塩基染料;HC Yellow 2、HC Yellow 5、HC Red 3、4-hydoxypropylamino-3-nitrophenol、N,N’-bis(2-hydroxyethyl)-2-nitro-p- phenylenediamine、HC Blue 2、Basic Blue 26等のニトロ染料;分散染料;二酸化チタン、酸化亜鉛等の無機白色顔料;酸化鉄(ベンガラ)、チタン酸鉄等の無機赤色系顔料;γ-酸化鉄等の無機褐色系顔料;黄酸化鉄、黄土等の無機黄色系顔料;黒酸化鉄、低次酸化チタン等の無機黒色系顔料;マンゴバイオレット、コバルトバイオレット等の無機紫色系顔料;酸化クロム、水酸化クロム、チタン酸コバルト等の無機緑色系顔料;群青、紺青等の無機青色系顔料;酸化チタンコーテッドマイカ、酸化チタンコーテッドオキシ塩化ビスマス、酸化チタンコーテッドタルク、着色酸化チタンコーテッドマイカ、オキシ塩化ビスマス、魚鱗箔等のパール顔料;アルミニウムパウダー、カッパーパウダー、金等の金属粉末顔料;表面処理無機及び金属粉末顔料;赤色201号、赤色202号、赤色204号、赤色205号、赤色220号、赤色226号、赤色228号、赤色405号、橙色203号、橙色204号、黄色205号、黄色401号、青色404号、赤色3号、赤色104号、赤色106号、赤色227号、赤色230号、赤色401号、赤色505号、橙色205号、黄色4号、黄色5号、黄色202号、黄色203号、緑色3号、青色1号等のジルコニウム、バリウム又はアルミニウムレーキ等の有機顔料;表面処理有機顔料;アスタキサンチン、アリザリン等のアントラキノン類、アントシアニジン、β-カロチン、カテナール、カプサンチン、カルコン、カルサミン、クエルセチン、クロシン、クロロフィル、クルクミン、コチニール、シコニン等のナフトキノン類、ビキシン、フラボン類、ベタシアニジン、ヘナ、ヘモグロビン、リコピン、リボフラビン、ルチン等の天然色素・染料;p-フェニレンジアミン、トルエン-2,5-ジアミン、o-,m-,若しくはp-アミノフェノール、m-フェニレンジアミン、5-アミノ-2-メチルフェノール、レゾルシン、1-ナフトール、2,6-ジアミノピリジン等及びその塩等の酸化染料中間体及びカップラー;インドリン等の自動酸化型染料;ジヒドロキシアセトンが好ましいものとして挙げられる。 Pigments, colorants, dyes, and pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, and Blue No. 204. , Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red No. 104-1 , Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213 , Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1 , Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505 , Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1 , Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow Legal dyes such as No. 407 and Yellow No. 5; Other acid dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, and HC Red. Nitro dyes such as 3,4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26; disperse dyes; titanium dioxide, zinc oxide Inorganic white pigments such as iron oxide (red iron oxide), iron titanate, etc.; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide, ocher; black iron oxide, low Inorganic black pigments such as titanium suboxide; Inorganic purple pigments such as mango violet and cobalt violet; Inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; Inorganic blue pigments such as ultramarine and navy blue; Pearl pigments such as titanium coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil; Metal powder pigments such as aluminum powder, copper powder, gold; surface treatment inorganic and Metal powder pigments; Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow 401 No., Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Organic pigments such as zirconium, barium, or aluminum lake such as Yellow No. 203, Green No. 3, and Blue No. 1; Surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenals, capsanthin, chalcone, and calsamine. , quercetin, crocin, chlorophyll, curcumin, cochineal, naphthoquinones such as shikonin, natural pigments and dyes such as bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2, Oxidation dyes such as 5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, etc., and salts thereof. Preferable examples include intermediates and couplers; autooxidative dyes such as indoline; and dihydroxyacetone.
水としては、常水、精製水の他、硬水、軟水、天然水、海洋深層水、電解アルカリイオン水、電解酸性イオン水、イオン水、クラスター水が好ましいものとして挙げられる。 Preferred examples of water include regular water, purified water, hard water, soft water, natural water, deep ocean water, electrolyzed alkaline ionized water, electrolyzed acidic ionized water, ionized water, and cluster water.
これらの他、化粧品原料基準、化粧品種別配合成分規格、日本化粧品工業連合会成分表示名称リスト、INCI辞書(The International Cosmetic Ingredient Dictionary and Handbook)、医薬部外品原料規格、日本薬局方、医薬品添加物規格、食品添加物公定書等に記載されている成分、及び、国際特許分類IPCがA61K7及びA61K8の分類に属する日本国及び諸外国特許公報及び特許公開公報(公表公報・再公表を含む)に記載されている成分等、公知の化粧料成分、医薬品成分、食品成分などを、公知の組み合わせ及び配合比・配合量で含有させることが可能である。 In addition to these, standards for cosmetic raw materials, standards for combination ingredients by cosmetic type, Japan Cosmetic Industry Federation ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), standards for quasi-drug raw materials, Japanese Pharmacopoeia, and pharmaceutical additives. Ingredients listed in standards, food additive regulations, etc., and international patent classification IPC in Japanese and foreign patent publications and patent publications (including publications and re-publications) that belong to the A61K7 and A61K8 classifications. It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the listed ingredients, in known combinations, blending ratios, and amounts.
本発明の化粧料の種類としては、毛髪化粧料、基礎化粧料、メイクアップ化粧料、芳香化粧料、ボディ化粧料、軟膏等の皮膚外用剤等が挙げられる。本発明の効果を発揮させる観点から、特に毛髪用化粧料、基礎化粧料に好ましく使用することができる。本発明の化粧料は、通常の方法に従って製造することができる。 Examples of the cosmetics of the present invention include hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and external skin preparations such as ointments. From the viewpoint of exhibiting the effects of the present invention, it can be particularly preferably used in hair cosmetics and basic cosmetics. The cosmetic of the present invention can be manufactured according to a conventional method.
本発明の化粧料の種類をさらに詳細に説明すると、毛髪化粧料としては、オイルシャンプー、クリームシャンプー、コンディショニングシャンプー、ふけ用シャンプー、ヘアカラー用シャンプー、リンス一体型シャンプー等のシャンプー;リンス、トリートメント、ヘアパック、ヘアミスト等のコンディショナー;ヘアフォーム、ヘアムース、ヘアスプレー、ヘアワックス、ヘアジェル、ヘアクリーム、ウォーターグリース、セットローション、ポマード、チック等の整髪料;カラーローション、ヘアトニック、ヘアリキッド、ヘアブロー、枝毛コート、ヘアオイル、パーマネントウェーブ用剤、ストレートパーマ剤、酸化染毛剤、ヘアブリーチ、ヘアカラープレトリートメント、ヘアカラーアフタートリートメント、パーマプレトリートメント、パーマアフタートリートメント、ヘアマニキュア、育毛剤が好ましいものとして挙げられる。 To explain the types of cosmetics of the present invention in more detail, hair cosmetics include shampoos such as oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair coloring shampoos, conditioner-integrated shampoos; conditioners, treatments, Conditioners such as hair packs and hair mist; Hair products such as hair foam, hair mousse, hair spray, hair wax, hair gel, hair cream, water grease, setting lotion, pomade, and ticks; Color lotion, hair tonic, hair liquid, hair blow, hair branches, etc. Preferable examples include hair coat, hair oil, permanent waving agent, straight perm agent, oxidative hair dye, hair bleach, hair color pre-treatment, hair color after-treatment, perm pre-treatment, perm after-treatment, hair manicure, and hair growth agent. It will be done.
基礎化粧料としては、柔軟化粧水、収れん化粧水、洗浄用化粧水、多層式化粧水等の化粧水;エモリエントローション、モイスチャーローション、ミルキィーローション、ナリシングローション、ナリシングミルク、スキンモイスチャー、モイスャーエマルション、マッサージローション、クレンジングローション、プロテクトエマルション、サンプロテクト、サンプロテクター、UVケアミルク、サンスクリーン、メイクアップローション、角質スムーザー、エルボーローション、ハンドローション、ボディローション等の乳液;エモリエントクリーム、栄養クリーム、ナリシングクリーム、バニシングクリーム、モイスチャークリーム、ナイトクリーム、マッサージクリーム、クレンジングクリーム、メイクアップクリーム、ベースクリーム、プレメイクアップクリーム、サンスクリーンクリーム、サンタンクリーム、除毛クリーム、デオドラントクリーム、シェービングクリーム、角質軟化クリーム等のクリーム;モイスチャージェル等のジェル;保湿エッセンス、美白エッセンス、紫外線防止エッセンス等のエッセンス;リポソーム美容液、リポソーム化粧水等のリポソーム化粧品類;ピールオフパック、粉末パック、ウォッシングパック、オイルパック、クレンジングマスク等のパック・マスク類;クレンジングフォーム、クレンジングクリーム、クレンジングミルク、クレンジングローション、クレンジングジェル、クレンジングオイル、クレンジングマスク、洗粉、洗顔パウダー等の洗顔料;化粧石鹸、透明石鹸、薬用石鹸、液状石鹸、ひげそり石鹸、合成化粧石鹸等の石鹸が好ましいものとして挙げられる。 Basic cosmetics include lotions such as softening lotion, astringent lotion, cleaning lotion, and multilayer lotion; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, and moisturizer. - Emulsion, massage lotion, cleansing lotion, protect emulsion, sun protector, UV care milk, sunscreen, makeup lotion, exfoliating smoother, elbow lotion, hand lotion, body lotion, etc.; emollient cream, nutritional cream, Nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream Creams such as creams; Gels such as moisture gels; Essences such as moisturizing essences, whitening essences, and UV protection essences; Liposomal cosmetics such as liposome serums and liposome lotions; Peel-off packs, powder packs, washing packs, oil packs, cleansing Packs and masks such as masks; Facial cleansers such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, cleansing powder, and facial cleansing powder; Toilet soap, transparent soap, medicated soap, liquid soap, Preferred examples include soaps such as shaving soap and synthetic cosmetic soap.
メイクアップ化粧料としては、白粉・打粉類、ファンデーション類、口紅類、リップグロス、頬紅類、アイライナー、マスカラ、アイシャドー、眉墨、アイブロー、ネイルエナメル、エナメルリムーバー、ネイルトリートメントが好ましいものとして挙げられる。 Preferred examples of makeup cosmetics include white powders, powders, foundations, lipsticks, lip glosses, blushers, eyeliners, mascaras, eyeshadows, eyebrow ink, eyebrows, nail enamel, enamel remover, and nail treatments. .
芳香化粧料としては、香水、パフューム、パルファム、オードパルファム、オードトワレ、オーデコロン、練香水、芳香パウダー、香水石鹸、ボディローション、バスオイルが好ましいものとして挙げられる。 Preferred examples of aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfume paste, aromatic powder, perfumed soap, body lotion, and bath oil.
ボディ化粧料としては、ボディシャンプー等のボディ洗浄料、デオドラントローション、デオドラントパウダー、デオドラントスプレー、デオドラントスティック等の防臭化粧料、脱色剤、脱毛・除毛剤、浴用剤、虫よけスプレー等のインセクトリペラーが好ましいものとして挙げられる。 Body cosmetics include body cleansing products such as body shampoo, deodorizing cosmetics such as deodorant lotion, deodorant powder, deodorant spray, and deodorant stick, bleaching agents, hair removal agents, bath additives, insect repellent sprays, etc. Repellers are preferred.
また、皮膚外用剤としては、軟膏剤、貼付剤、ローション剤、リニメント剤、液状塗布剤などの剤型で用いることができる。また、歯磨き、マウスウォッシュ等の口腔内化粧料としても用いることが出来る。 Further, as a skin external preparation, it can be used in the form of an ointment, a patch, a lotion, a liniment, a liquid coating, and the like. It can also be used as oral cosmetics such as toothpaste and mouthwash.
本発明の化粧料又は皮膚外用剤の剤型としては、水中油(O/W)型、油中水(W/O)型、W/O/W型、O/W/O型等の乳化型化粧料、油性化粧料、固形化粧料、液状化粧料、練状化粧料、スティック状化粧料、揮発性油型化粧料、粉状化粧料、ゼリー状化粧料、ジェル状化粧料、ペースト状化粧料、乳化高分子型化粧料、シート状化粧料、ミスト状化粧料、スプレー型化粧料等の剤型が好ましいものとして挙げられる。 The dosage form of the cosmetic or external skin preparation of the present invention includes emulsions such as oil-in-water (O/W) type, water-in-oil (W/O) type, W/O/W type, O/W/O type, etc. Molded cosmetics, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil-based cosmetics, powder cosmetics, jelly-like cosmetics, gel-like cosmetics, paste-like cosmetics Preferable formulations include cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.
以上、本発明の実施形態について説明したが、本発明はこうした例に何ら限定されるものではなく、本発明の要旨を逸脱しない範囲において種々なる形態で実施し得ることは勿論である。 Although the embodiments of the present invention have been described above, the present invention is not limited to these examples at all, and it goes without saying that the present invention can be implemented in various forms without departing from the gist of the present invention.
以下、実施例に基づき、本発明の実施形態をより具体的に説明するが、本発明がこれらに限定されるものではない。 Hereinafter, embodiments of the present invention will be described in more detail based on Examples, but the present invention is not limited thereto.
(製造例1)
イヌリン組成物の調製
原料である砂糖溶液の濃度を45%に調製し、55℃にてイヌリン合成酵素を添加し、緩やかに撹拌しながら2日間の酵素反応を行った。なお、反応24時間目に原料溶液を追添加しさらに反応を続け、砂糖の残量が糖組成で10%程度になった時点で反応を終了させた。反応終了液は加熱により酵素を熱変性させ、活性炭ろ過による脱色工程、逆浸透膜による低分子糖類の除去工程、イオン交換樹脂による脱塩工程を経て精製を行い、噴霧乾燥よって純度97%以上の粉末を得ることができる。このようにして得られる酵素的合成イヌリンの重合度について分析を行ったところ、平均重合度16、重合度分布は5~29であり、重合度5~29のイヌリンの占有率は96.2%であった。
(Manufacturing example 1)
Preparation of inulin composition
The concentration of the raw material sugar solution was adjusted to 45%, inulin synthase was added at 55°C, and the enzyme reaction was carried out for 2 days with gentle stirring. The raw material solution was further added at 24 hours of the reaction, and the reaction was further continued, and the reaction was terminated when the remaining amount of sugar reached about 10% in terms of sugar composition. The reaction solution is purified by heating to thermally denature the enzyme, decolorizing by activated carbon filtration, removing low molecular weight sugars by reverse osmosis membrane, desalting by ion exchange resin, and purified by spray drying to a purity of 97% or more. A powder can be obtained. When the degree of polymerization of the enzymatically synthesized inulin thus obtained was analyzed, the average degree of polymerization was 16, the distribution of degrees of polymerization was 5 to 29, and the occupancy rate of inulin with a degree of polymerization of 5 to 29 was 96.2%. Met.
イヌリン組成物の平均重合度
本発明では平均重合度を以下の条件で測定した。標準物質としては、植物由来のイヌリンであるオラフティ社のラフティリンST(平均重合度11)とラフティリンHP(平均重合度22)を用いた。
HPLC条件
カラム: TOSOH TSK-GEL G3000PWXL(7.8×300mm) 溶媒 : 水
流速 : 0.5mL/分
温度 : 50℃
検出器: 示差屈折計
Average degree of polymerization of inulin composition In the present invention, the average degree of polymerization was measured under the following conditions. As standard substances, Laughtilin ST (average degree of polymerization 11) and Laughtilin HP (average degree of polymerization 22) manufactured by Orafty, which are plant-derived inulins, were used.
HPLC conditions Column: TOSOH TSK-GEL G3000PWXL (7.8 x 300 mm) Solvent: Water Flow rate: 0.5 mL/min Temperature: 50°C
Detector: Differential refractometer
イヌリン組成物の重合度分布
本発明ではイヌリン組成物の重合度の分布状態はイオンクロマト分析装置を用いて測定した。製造例1で得られた本発明のイヌリン組成物(フジFF)と代表的なイヌリン製品の重合度の分布状態は図1に示すとおりである(非特許文献1より抜粋)。図1の結果から、植物由来のイヌリン(キクイモイヌリン、チコリイヌリン、ダリアイヌリン)には全て重合度30以上のイヌリンが含まれているのに対し、本発明のイヌリン組成物(フジFF)は重合度30以上のものが含まれていないことがうかがえる。また市販のイヌリンであるラフティリンHP(オラフティ社製)やラフティリンST(オラフティ社製)も、本発明のイヌリン組成物(フジFF)とは大きく異なる。ラフティリンはチコリ由来イヌリンを重合度で分別したものである。
Polymerization degree distribution of inulin composition In the present invention, the degree of polymerization distribution of the inulin composition was measured using an ion chromatography analyzer. The distribution state of the degree of polymerization of the inulin composition of the present invention (Fuji FF) obtained in Production Example 1 and a typical inulin product is as shown in FIG. 1 (excerpted from Non-Patent Document 1). From the results in Figure 1, it can be seen that plant-derived inulin (kikuimo inulin, chicory inulin, and dahlia inulin) all contain inulin with a polymerization degree of 30 or higher, whereas the inulin composition of the present invention (Fuji FF) has a polymerization degree of 30 or higher. It can be seen that substances with a degree of 30 or higher are not included. Furthermore, commercially available inulins such as Laftilin HP (manufactured by Orafti) and Laftilin ST (manufactured by Orafty) are also significantly different from the inulin composition of the present invention (Fuji FF). Raftilin is obtained by fractionating chicory-derived inulin based on the degree of polymerization.
<溶解性評価>
製造例1のイヌリン組成物を表1の組成で水に溶解し、初期の溶解性と5℃/1ヵ月保管後の安定性について、下記の評価基準にて評価した。比較としてチコリイヌリンを使用した。結果は表1に併記した。
○:結晶の析出がみられない
△:結晶の析出がわずかにみられる
×:結晶の析出が多くみられる
<Solubility evaluation>
The inulin composition of Production Example 1 was dissolved in water according to the composition shown in Table 1, and the initial solubility and stability after storage at 5°C/1 month were evaluated using the following evaluation criteria. Chicory inulin was used as a comparison. The results are also listed in Table 1.
○: No crystal precipitation observed △: Slight crystal precipitation observed ×: Much crystal precipitation observed
表1の結果より、重合度分布の広いチコリイヌリンに比較して、本発明のイヌリン組成物は初期の溶解性、保管安定性ともに良好であった。保管安定性については、本発明のイヌリン組成物を10重量%溶解した実施例2でわずかに析出がみられたが、シロキクラゲ多糖体、ヒアルロン酸、キサンタンガムを併用することで保管安定性が向上することが分かった。 From the results in Table 1, the inulin composition of the present invention had better initial solubility and storage stability than chicory inulin, which has a wide polymerization degree distribution. Regarding storage stability, slight precipitation was observed in Example 2 in which 10% by weight of the inulin composition of the present invention was dissolved, but the storage stability was improved by the combined use of white fungus polysaccharide, hyaluronic acid, and xanthan gum. That's what I found out.
<使用感の評価>
製造例1のイヌリン組成物を使用して表2の組成の化粧水を作製した。比較としてチコリイヌリンを使用した化粧水及びイヌリンを配合していない化粧水を作製した。得られた化粧水について、塗布時のべたつき感と乾燥後のさらさら感の2項目について下記の評価基準で評価した。結果は、パネラー5名の評点の平均点に基づき、下記の判定基準で示した。結果は表2に記載した。
<塗布時のべたつき感>
全く感じない :5点
あまり感じない :4点
普通 :3点
やや感じる :2点
非常に感じる :1点
<乾燥後のさらさら感>
非常に感じる :5点
やや感じる :4点
普通 :3点
あまり感じない :2点
全く感じない :1点
判定基準
[評点の平均点] :[判定]
4.5以上 : ◎
3.5以上~4.5未満 : ○
1.5以上~3.5未満 : △
1.5未満 : ×
<Evaluation of usability>
A lotion having the composition shown in Table 2 was prepared using the inulin composition of Production Example 1. For comparison, a lotion using chicory inulin and a lotion not containing inulin were prepared. The resulting lotion was evaluated using the following evaluation criteria for two items: stickiness upon application and dryness after drying. The results were shown based on the average score of the five panelists and according to the following criteria. The results are listed in Table 2.
<Sticky feeling during application>
Not feeling it at all: 5 points Not feeling it much: 4 points Average: 3 points Feeling it a little: 2 points Feeling it very much: 1 point <Smooth feeling after drying>
Feel it very much: 5 points Feel it a little: 4 points Average: 3 points Not feel it much: 2 points Not feel it at all: 1 point Judgment criteria [Average score]: [Judgment]
4.5 or more: ◎
3.5 or more - less than 4.5: ○
1.5 or more - less than 3.5: △
Less than 1.5: ×
表2の結果より、重合度分布の広いチコリイヌリンに比較して、本発明のイヌリン組成物は使用感に優れるものであった。また、本発明のイヌリン組成物を配合していない比較例4の化粧水はグリセリンの影響により、べたつき感、さらさら感ともに悪い結果であったが、本発明のイヌリン組成物を配合することで、このようなポリオールの好ましくない使用感を低減できることが分かった。 From the results in Table 2, the inulin composition of the present invention was superior in feel when used compared to chicory inulin, which has a wide distribution of polymerization degrees. In addition, the lotion of Comparative Example 4, which did not contain the inulin composition of the present invention, had poor stickiness and dryness due to the influence of glycerin, but by blending the inulin composition of the present invention, It has been found that such undesirable feeling of use of polyols can be reduced.
<泡質改善評価>
製造例1のイヌリン組成物を使用して表3の組成の皮膚洗浄剤を作製した。比較としてチコリイヌリンを使用した皮膚洗浄剤及びイヌリンを配合していない皮膚洗浄剤を作製した。得られた皮膚洗浄剤について、泡の細かさ、泡のもちもち感、洗浄後のさらさら感、洗浄後のしっとり感について評価した。評価方法としては、泡の細かさについては、マイクロスコープを用いて確認し、下記の評価基準に基づいて評価した。泡のもちもち感、使用後のさらさら感、使用後のしっとり感については、官能にて下記の評価基準で評価し、パネラー5名の評点の平均点に基づき、下記の判定基準で示した。結果は表3に記載した。
<泡の細かさ>
非常に細かい : ◎
細かい : ○
少し細かい : △
細かくない : ×
<泡のもちもち感>
非常に感じる :5点
やや感じる :4点
普通 :3点
あまり感じない :2点
全く感じない :1点
<洗浄後のさらさら感>
非常に感じる :5点
やや感じる :4点
普通 :3点
あまり感じない :2点
全く感じない :1点
<洗浄後のしっとり感>
非常に感じる :5点
やや感じる :4点
普通 :3点
あまり感じない :2点
全く感じない :1点
判定基準
[評点の平均点] :[判定]
4.5以上 : ◎
3.5以上~4.5未満 : ○
1.5以上~3.5未満 : △
1.5未満 : ×
<Foam quality improvement evaluation>
Using the inulin composition of Production Example 1, a skin cleansing agent having the composition shown in Table 3 was prepared. For comparison, a skin cleansing agent using chicory inulin and a skin cleansing agent containing no inulin were prepared. The obtained skin cleanser was evaluated for the fineness of the foam, the sticky feeling of the foam, the dry feeling after washing, and the moist feeling after washing. As an evaluation method, the fineness of the bubbles was confirmed using a microscope and evaluated based on the following evaluation criteria. The chewy feeling of the foam, the dry feeling after use, and the moist feeling after use were evaluated by sensory evaluation using the following evaluation criteria, and based on the average score of the five panelists, the following criteria were used. The results are listed in Table 3.
<Fineness of bubbles>
Very detailed: ◎
Detailed: ○
A little fine: △
Not detailed: ×
<Spacious feeling of bubbles>
Very felt: 5 points Somewhat felt: 4 points Average: 3 points Not very felt: 2 points Not at all: 1 point <Dry feeling after washing>
Very felt: 5 points Somewhat felt: 4 points Average: 3 points Not so much: 2 points Not at all: 1 point <Moist feeling after washing>
Feel it very much: 5 points Feel it a little: 4 points Average: 3 points Not feel it much: 2 points Not feel it at all: 1 point Judgment criteria [Average score]: [Judgment]
4.5 or more: ◎
3.5 or more - less than 4.5: ○
1.5 or more - less than 3.5: △
Less than 1.5: ×
表3の結果より、重合度分布の広いチコリイヌリンに比較して、本発明のイヌリン組成物は泡質の改善効果に優れ、また、洗浄後のさらさら感やしっとり感といった使用感にも優れるものであった。また、シロキクラゲ多糖体、ヒアルロン酸を併用することで泡質の改善効果が向上することが分かった。 From the results in Table 3, compared to chicory inulin, which has a wide polymerization degree distribution, the inulin composition of the present invention has an excellent effect on improving foam quality, and also has an excellent feeling of use such as a dry and moist feeling after washing. Met. In addition, it was found that the effect of improving foam quality was improved by the combined use of white fungus polysaccharide and hyaluronic acid.
<表皮ヒアルロン酸産生促進評価>
本発明のイヌリン組成物を表4に記載の各濃度で添加した培地において、正常ヒト表皮細胞を48時間培養した後、培地上清中のヒアルロン酸量をELISA法により定量した。定量結果より、本発明のイヌリン組成物無添加の培地で培養した際のヒアルロン酸量を100%としてヒアルロン酸産生促進率を算出し、結果を表4に併記した。
<Evaluation of promotion of epidermal hyaluronic acid production>
After normal human epidermal cells were cultured for 48 hours in a medium to which the inulin composition of the present invention was added at each concentration listed in Table 4, the amount of hyaluronic acid in the medium supernatant was quantified by ELISA. From the quantitative results, the hyaluronic acid production promotion rate was calculated by setting the amount of hyaluronic acid when cultured in a medium without the addition of the inulin composition of the present invention as 100%, and the results are also listed in Table 4.
表4の結果より、本発明のイヌリン組成物は、無添加に比較してヒアルロン酸量が有意に増加しており、優れたヒアルロン酸産生促進作用があることが分かった。 From the results in Table 4, it was found that the inulin composition of the present invention had a significantly increased amount of hyaluronic acid compared to the composition without additives, and had an excellent effect of promoting hyaluronic acid production.
本発明のイヌリン組成物を用いて、以下に記載のプレミックス組成物及び化粧料を作製した。得られた化粧料は、優れた保湿性を有し、べたつきが低減され、さらさらした使用感が付与されたものであり、洗浄剤においては泡質が改善されたものであった。 Using the inulin composition of the present invention, premix compositions and cosmetics described below were prepared. The obtained cosmetics had excellent moisturizing properties, reduced stickiness, and a smooth feel, and the detergents had improved foam quality.
(実施例12)
プレミックス組成物
成 分 配合量(重量%)
----------------------------------------A部
製造例1のイヌリン組成物 10.0
フェノキシエタノール 1.00
精製水 合計で100となる量
クエン酸 0.06
クエン酸Na 0.24
B部
シロキクラゲ多糖体
(Tremoist-TP:日本精化) 0.10
精製水 10.0
----------------------------------------(調製方法)
A部を50℃に加温し、溶解させた。B部を均一に溶解した。B部を常温で攪拌しながらゆっくり加え、均一な液とした。
(Example 12)
premix composition
Component Amount (weight%)
--------------------------------------- Part A Inulin composition of Production Example 1 10.0
Phenoxyethanol 1.00
Purified water Amount that makes a total of 100 Citric acid 0.06
Sodium citrate 0.24
Part B White fungus polysaccharide (Tremoist-TP: Nippon Fine Chemical) 0.10
Purified water 10.0
----------------------------------------(Preparation method)
Part A was heated to 50°C and dissolved. Part B was uniformly dissolved. Part B was slowly added while stirring at room temperature to form a homogeneous solution.
(実施例13)
化粧水
成 分 配合量(重量%)
----------------------------------------A部
BG 4.0
イノシト-ル 0.5
グリチルリチン酸2K 0.01
エタノール 3.0
フェノキシエタノール 0.2
メチルパラベン 0.15
クエン酸 0.1
クエン酸Na pHが4.5になる量
精製水 合計で100となる量
B部
キサンタンガム 0.05
BG 3.0
精製水 20.0
C部
VCエチル(日本精化) 0.1
精製水 5.0
D部
実施例12の組成物 5.0
----------------------------------------(調製方法)
B部を混合し粘性な液を調整した。A部を約80℃に加温し、均一に溶解した。A部にB部を攪拌しながらゆっくり加え、40℃まで冷却した後、C部、D部を添加し、均一な液とした。
(Example 13)
lotion
Component Amount (weight%)
------------------------------------------------------------------------------ Part BG 4.0
Inositol 0.5
Glycyrrhizic acid 2K 0.01
Ethanol 3.0
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Sodium citrate Amount that makes the pH 4.5 Purified water Amount that makes the total 100 Part B Xanthan gum 0.05
BG 3.0
Purified water 20.0
Part C VC ethyl (Nippon Fine Chemical) 0.1
Purified water 5.0
Part D Composition of Example 12 5.0
----------------------------------------(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A was heated to about 80°C to uniformly dissolve it. Part B was slowly added to Part A with stirring, and after cooling to 40°C, Parts C and D were added to form a homogeneous liquid.
(実施例14)
化粧水
成 分 配合量(重量%)----------------------------------------A部
Phytopresome MEL(日本精化) 3.0
DPG 3.0
グリセリン 1.0
B部
精製水 20.0
C部
Neosolue-Aqulio(日本精化) 0.5
ナイアシンアミド 0.3
ベタイン 1.0
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
D部
実施例12の組成物 5.0
----------------------------------------(調製方法)
A部を混合し、B部に攪拌しながらゆっくり加えた。さらにあらかじめ混合したC部、D部を添加し、均一な液とした。
(Example 14)
lotion
Ingredients Amount (% by weight) ---------------------- Part A Phytopresome MEL (Nippon Fine Chemical) 3.0
DPG 3.0
glycerin 1.0
Part B Purified water 20.0
C part Neosolue-Aqulio (Nippon Fine Chemical) 0.5
Niacinamide 0.3
betaine 1.0
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Amount that makes the total 100 Part D Composition of Example 12 5.0
----------------------------------------(Preparation method)
Part A was mixed and slowly added to Part B with stirring. Furthermore, Part C and Part D, which had been mixed in advance, were added to form a uniform liquid.
(実施例15)
保湿化粧水
成 分 配合量(重量%)
---------------------------------------
A部
ジグリセリン 3.0
加水分解ヒアルロン酸 0.01
アルギニン 0.05
Neosolue-AquaS(日本精化) 1.0
ベタイン 0.5
プルラン 0.5
ヒドロキシエチルセルロース 0.03
カルボマー 0.05
アルギニン 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
B部
実施例12の組成物 5.0
ヒアルロン酸Na 0.01
精製水 10.0
---------------------------------------
(調製方法)
A部を約80℃に加温し、均一に混合した。B部を添加し、均一な液とした。
(Example 15)
moisturizing lotion
Component Amount (weight%)
--------------------------------------
Part A Diglycerin 3.0
Hydrolyzed hyaluronic acid 0.01
Arginine 0.05
Neosolue-AquaS (Nippon Fine Chemical) 1.0
Betaine 0.5
Pullulan 0.5
Hydroxyethylcellulose 0.03
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Total amount of 100 Part B Composition of Example 12 5.0
Hyaluronic acid Na 0.01
Purified water 10.0
--------------------------------------
(Preparation method)
Part A was heated to about 80°C and mixed uniformly. Part B was added to make a homogeneous solution.
(実施例16)
保湿化粧水
成 分 配合量(重量%)----------------------------------------A部
ジグリセリン 3.0
Neosolue-AquaS(日本精化) 1.0
PEG/PPG/ポリブチレングリコール-8/5/3グリセリン 0.5
グルコシルセラミド 0.5
グルコシルルチン 0.01
ポリクオタニウム-51 0.5
アセチルヘキサぺプチド-8 0.001
加水分解コラーゲン 0.05
カルボマー 0.05
アルギニン 0.05
フェノキシエタノール 0.2
メチルパラベン 0.15
キサンタンガム 0.1
精製水 合計で100となる量
B部
製造例1のイヌリン組成物 5.0
Tremoist-TP(日本精化) 0.01
精製水 10.0
----------------------------------------(調製方法)
A部を約80℃で均一に溶解し、B部を添加し、均一な液とした。
(Example 16)
moisturizing lotion
Ingredients Amount (% by weight) ---------------------- Part A diglycerin 3.0
Neosolue-AquaS (Nippon Fine Chemical) 1.0
PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin 0.5
Glucosylceramide 0.5
Glucosylrutin 0.01
Polyquaternium-51 0.5
Acetyl hexapeptide-8 0.001
Hydrolyzed collagen 0.05
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Xanthan gum 0.1
Purified water Total amount of 100 Part B Inulin composition of Production Example 1 5.0
Tremoist-TP (Nippon Fine Chemical) 0.01
Purified water 10.0
----------------------------------------(Preparation method)
Part A was uniformly dissolved at about 80°C, and Part B was added to form a uniform liquid.
(実施例17)
ジェル化粧水
成 分 配合量(重量%)
------------------------------------
A部
Phytocompo-PP(日本精化) 1.0
グリセリン 5.0
ソルビトール液(70%) 5.0
ベヘン酸グリセリル 0.8
ステアリン酸 0.3
PEG-10ジメチコン 0.4
B部
フェノキシエタノール 0.3
プルラン 0.2
エチルヘキシルグリセリン 0.2
ポリHEMAグルコシド 0.05
ポリメタクリロイルリシン 0.05
結晶セルロース末 0.1
ローカストビーンガム 0.03
ヒドロキシエチルセルロース 0.05
ヒアルロン酸Na 0.01
カルボマー 0.06
水酸化K 0.05
精製水 合計で100となる量
C部
製造例1のイヌリン組成物 3.0
Tremoist-TP(日本精化) 0.1
精製水 10.0
-------------------------------------
(調製方法)
A部を約70℃に加温し、均一に分散させた。B部を混合、よく攪拌し、均一にしたのち約70℃に加温した。A部にB部を加え、約70℃でホモミキサーを用い撹拌し、約40℃まで冷却し、C部を添加した。
(Example 17)
gel lotion
Component Amount (wt%)
------------------------------------
Part A Phytocompo-PP (Nippon Fine Chemical) 1.0
glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl behenate 0.8
Stearic acid 0.3
PEG-10 dimethicone 0.4
Part B Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexylglycerin 0.2
PolyHEMA glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust Bean Gum 0.03
Hydroxyethylcellulose 0.05
Hyaluronate Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Purified water Amount that makes a total of 100 Part C Inulin composition of Production Example 1 3.0
Tremoist-TP (Nippon Fine Chemical) 0.1
Purified water 10.0
------------------------------------
(Preparation method)
Part A was heated to about 70°C and uniformly dispersed. Part B was mixed and stirred well to make the mixture uniform, and then heated to about 70°C. Part B was added to Part A, stirred at about 70°C using a homomixer, cooled to about 40°C, and Part C was added.
(実施例18)
透明ジェル
成 分 配合量(重量%)
---------------------------------------
A部
グリセリン 3.0
PEG-4000 0.2
メチルグルセス-10 1.0
フェノキシエタノール 0.3
ピリドキシン塩酸塩 0.05
エチルヘキシルグリセリン 0.2
ヒドロキシエチルセルロース 0.05
加水分解コラーゲン 0.01
精製水 合計で100となる量
B部
(アクリル酸ジメチルタウリンアンモニウム/ビニルピロリドン)コポリマー
0.05
(アクリレーツ/アクリル酸アルキル(C10-30))クロスポリマー 0.15
アルギニン 0.25
精製水 30.0
C部
実施例12の組成物 8.0
----------------------------------------(調製方法)
A部を攪拌し、均一な液とした。B部を混合し、粘性の液とした。A部に、B部、C部を加え均一にした。
(Example 18)
transparent gel
Component Amount (wt%)
--------------------------------------
Part A Glycerin 3.0
PEG-4000 0.2
Methylgluceth-10 1.0
Phenoxyethanol 0.3
Pyridoxine hydrochloride 0.05
Ethylhexylglycerin 0.2
Hydroxyethylcellulose 0.05
Hydrolyzed collagen 0.01
Purified water Amount to make a total of 100 Part B (dimethyltaurate ammonium acrylate/vinylpyrrolidone) copolymer
0.05
(Acrylates/Alkyl acrylate (C10-30)) Crosspolymer 0.15
Arginine 0.25
Purified water 30.0
Part C Composition of Example 12 8.0
----------------------------------------(Preparation method)
Part A was stirred to make a homogeneous liquid. Part B was mixed to form a viscous liquid. Parts B and C were added to part A to make it uniform.
(実施例19)
乳液
成 分 配合量(重量%)
---------------------------------------
A部
リンゴ酸ジイソステアリル 5.0
Plandool-DP(日本精化) 1.0
エチルヘキサン酸セチル(NS-CIO:日本精化) 10.0
セタノール 1.2
フェニルトリメチコン 3.0
エチルパラベン 0.1
ミリスチルアルコール 2.0
オレイルアルコール 1.0
B部
ステアロキシヒドロキシプロピルメチルセルロース 0.1
キサンタンガム 0.1
精製水 20.0
C部
Phytocompo-PP(日本精化) 1.0
ペンチレングリコール 3.0
グリセリン 8.0
D部
実施例12の組成物 5.0
E部
フェノキシエタノール 0.2
メチルパラベン 0.15
フィチン酸 0.5
クエン酸 適量
クエン酸Na 適量
精製水 合計で100となる量
---------------------------------------
(調製方法)
A部、E部をそれぞれ約70℃に加温し、均一に溶解させた。B部を攪拌して粘性の液とした。C部を約70℃に加温し、均一に分散させた。C部をホモディスパーにて攪拌しながらA部を加えた後、E部を攪拌しながら添加した。約50℃でD部、B部を加え、攪拌して均一に溶解した。
(Example 19)
emulsion
Component Amount (wt%)
--------------------------------------
Part A Diisostearyl malate 5.0
Plandool-DP (Nippon Fine Chemical) 1.0
Cetyl ethylhexanoate (NS-CIO: Nippon Fine Chemical) 10.0
Setanol 1.2
Phenyltrimethicone 3.0
Ethylparaben 0.1
Myristyl alcohol 2.0
Oleyl alcohol 1.0
Part B Stearoxyhydroxypropyl methylcellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Phytocompo-PP (Nippon Fine Chemical) 1.0
Pentylene glycol 3.0
Glycerin 8.0
Part D Composition of Example 12 5.0
Part E Phenoxyethanol 0.2
Methylparaben 0.15
Phytic acid 0.5
Citric acid (appropriate amount) Sodium citrate (appropriate amount) Purified water Amount that makes a total of 100--------------------------------- ---
(Preparation method)
Part A and Part E were each heated to about 70°C to uniformly dissolve them. Part B was stirred to form a viscous liquid. Part C was heated to about 70°C and uniformly dispersed. Part A was added to part C while stirring with a homodisper, and then part E was added while stirring. Part D and Part B were added at about 50°C and stirred to uniformly dissolve.
(実施例20)
乳液
成 分 配合量(重量%)
-------------------------------------
A部
グリセリン 3.0
ジグリセリン 1.0
BG 7.0
Phytocompo-C(日本精化) 1.0
水添リゾレシチン(LP70H:日本精化) 0.1
B部
ミネラルオイル 5.0
トリエチルヘキサノイン(IOTG:日本精化) 3.0
LUSPLAN SR-DM4(日本精化) 0.5
水添ポリイソブテン 3.5
イソドデカン 1.5
セトステアリルアルコール 1.0
アラキルアルコール 0.1
ホホバアルコール 3.0
キミルアルコール 0.3
セラキルアルコール 0.1
ヘキシルデカノール 0.5
C部
アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)コポリマー
0.2
カルボマー 0.1
精製水 20.0
D部
Neosolue-AquaS(日本精化) 0.5
ポリクオタニウム-51 1.0
アスコルビルグルコシド 1.0
水酸化カリウム 0.2
フェノキシエタノール 0.2
メチルパラベン 0.15
精製水 合計で100となる量
E部
製造例1のイヌリン組成物 3.0
Tremoist-TP(日本精化) 0.1
精製水 10.0
-------------------------------------
(調製方法)
A部、B部、D部をそれぞれ混合し、約70℃に加温し、均一に溶解、分散させた。C部を混合し、攪拌して粘性の液とした。A部をホモディスパーにて攪拌しながらB部を加えた後、D部を加えて乳化した。冷却し、約50℃にて、C部、E部を加え、攪拌して約40℃まで冷却した。
(Example 20)
emulsion
Component Amount (wt%)
------------------------------------
Part A Glycerin 3.0
diglycerin 1.0
BG 7.0
Phytocompo-C (Nippon Fine Chemical) 1.0
Hydrogenated lysolecithin (LP70H: Nippon Fine Chemical) 0.1
Part B Mineral oil 5.0
Triethylhexanoin (IOTG: Nippon Fine Chemical) 3.0
LUSPLAN SR-DM4 (Nippon Fine Chemical) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Cetostearyl alcohol 1.0
Arachyl alcohol 0.1
Jojoba alcohol 3.0
Chimyl alcohol 0.3
Serakyl alcohol 0.1
Hexyldecanol 0.5
Part C Hydroxyethyl acrylate/acryloyldimethyltaurine (Na) copolymer
0.2
Carbomer 0.1
Purified water 20.0
D part Neosolue-AquaS (Nippon Fine Chemical) 0.5
Polyquaternium-51 1.0
Ascorbyl glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Quantity E parts totaling 100 Inulin composition of Production Example 1 3.0
Tremoist-TP (Nippon Fine Chemical) 0.1
Purified water 10.0
------------------------------------
(Preparation method)
Part A, Part B, and Part D were mixed and heated to about 70°C to uniformly dissolve and disperse. Part C was mixed and stirred to form a viscous liquid. Part B was added to part A while stirring with a homodisper, and then part D was added and emulsified. After cooling, parts C and E were added at about 50°C, stirred, and cooled to about 40°C.
(実施例21)
スキンケアクリーム
成 分 配合量(重量%)
-------------------------------------
A部
グリセリン 9.0
DPG 5.0
Phytocompo-PP(日本精化) 1.0
B部
ミネラルオイル 8.0
ワセリン 10.0
テトライソステアリン酸ペンタエリスリチル 5.0
アスタキサンチン 0.01
セチルPGヒドロキシエチルパルミタミド 0.05
環状リゾホスファチジン酸Na 0.01
ヘキサヒドロキシステアリン酸ジペンタエリスリチル 1.0
C部
カルボマー 0.1
水酸化K 0.07
キサンタンガム 0.1
精製水 10.0
D部
フェノキシエタノール 0.4
エチルヘキシルグリセリン 0.2
メチルパラベン 0.05
精製水 合計で100となる量
E部
実施例12の組成物 5.0
-------------------------------------
(調製方法)
A部、B部、D部をそれぞれ混合し、約70℃に加温し、均一に溶解、分散させた。C部を混合し、攪拌して粘性の液とした。A部をホモディスパーにて攪拌しながらB部を加えた後、D部を加えて乳化した。冷却し、約50℃にて、C部、E部を加え、攪拌して約40℃まで冷却した。
(Example 21)
skin care cream
Component Amount (wt%)
------------------------------------
Part A Glycerin 9.0
DPG 5.0
Phytocompo-PP (Nippon Fine Chemical) 1.0
Part B Mineral oil 8.0
Vaseline 10.0
Pentaerythrityl tetraisostearate 5.0
Astaxanthin 0.01
Cetyl PG Hydroxyethyl Palmitamide 0.05
Cyclic lysophosphatidic acid Na 0.01
Dipentaerythrityl hexahydroxystearate 1.0
Part C Carbomer 0.1
Hydroxide K 0.07
Xanthan gum 0.1
Purified water 10.0
Part D Phenoxyethanol 0.4
Ethylhexylglycerin 0.2
Methylparaben 0.05
Purified water Amount E parts totaling 100 Composition of Example 12 5.0
------------------------------------
(Preparation method)
Part A, Part B, and Part D were mixed and heated to about 70°C to uniformly dissolve and disperse. Part C was mixed and stirred to form a viscous liquid. Part B was added to part A while stirring with a homodisper, and then part D was added and emulsified. After cooling, parts C and E were added at about 50°C, stirred, and cooled to about 40°C.
(実施例22)
スキンケアクリーム
成 分 配合量(重量%)
-------------------------------------
A部
スクワラン 10.0
ステアリン酸 1.0
Plandool-ISS(日本精化) 1.0
マカデミアナッツ油 3.0
水添ナタネ油アルコール 2.0
オリーブ油脂肪酸セテアリル 1.0
オリーブ油脂肪酸ソルビタン 0.8
オレイン酸ポリグリセリル-10 1.0
B部
アクリル酸・メタクリル酸アルキル共重合体 0.1
水酸化K 0.07
(アクリロイルジメチルタウリンアンモニウム/
メタクリル酸ベヘネス-25)クロスポリマー 0.2
精製水 10.0
加水分解ポリγ-グルタミン酸K 0.1
ポリグルタミン酸Na 0.1
オリゴペプチド-24 0.05
C部
グリセリン 9.0
プロパンジオール 10.0
PEG-8 5.0
メチルパラベン 0.1
フェノキシエタノール 0.3
精製水 合計で100となる量
D部
製造例1のイヌリン組成物 1.5
Tremoist-TP(日本精化) 0.05
精製水 10.0
-------------------------------------
(調製方法)
A部、C部をそれぞれ混合し、約70℃に加温し、均一に溶解、分散させた。B部を混合し、攪拌して粘性の液とした。D部を混合し、均一な液とした。C部をホモミキサーにて攪拌しながらA部を加えて乳化した。冷却し約50℃にて、B部、D部を加え、攪拌して約40℃まで冷却した。
(Example 22)
skin care cream
Component Amount (wt%)
------------------------------------
Part A Squalane 10.0
Stearic acid 1.0
Plandool-ISS (Nippon Fine Chemical) 1.0
Macadamia nut oil 3.0
Hydrogenated rapeseed oil alcohol 2.0
Olive oil fatty acid cetearyl 1.0
Olive oil fatty acid sorbitan 0.8
Polyglyceryl oleate-10 1.0
Part B Acrylic acid/alkyl methacrylate copolymer 0.1
Hydroxide K 0.07
(Acryloyldimethyltaurate ammonium/
Methacrylic acid beheneth-25) Crosspolymer 0.2
Purified water 10.0
Hydrolyzed polyγ-glutamic acid K 0.1
Sodium polyglutamate 0.1
Oligopeptide-24 0.05
Part C Glycerin 9.0
Propanediol 10.0
PEG-8 5.0
Methylparaben 0.1
Phenoxyethanol 0.3
Purified water Total amount of 100 Part D Inulin composition of Production Example 1 1.5
Tremoist-TP (Nippon Fine Chemical) 0.05
Purified water 10.0
------------------------------------
(Preparation method)
Part A and Part C were mixed and heated to about 70°C to uniformly dissolve and disperse. Part B was mixed and stirred to form a viscous liquid. Part D was mixed to form a homogeneous liquid. While stirring Part C with a homomixer, Part A was added and emulsified. After cooling to about 50°C, parts B and D were added, stirred, and cooled to about 40°C.
(実施例23)
スキンケアクリーム
成 分 配合量(重量%)
-------------------------------------
A部
ミネラルオイル 8.0
Plandool-MAS(日本精化) 2.0
Plandool-LG1(日本精化) 1.0
パラフィンワックス 3.0
シアバター 3.0
スクワラン 8.0
セタノール 1.8
水添ココグリセリル 0.8
ステアリン酸グリセリル 1.0
ベヘニルアルコール 1.5
ステアリン酸ソルビタン 1.0
セスキステアリン酸メチルグルコース 1.5
B部
キサンタンガム 0.1
ヒドロキシエチルセルロース 0.1
結晶セルロース末 0.3
ステアロキシヒドロキシプロピルメチルセルロース 0.1
精製水 20.0
C部
グリセリン 8.0
DPG 5.0
ソルビトール 2.0
メチルパラベン 0.15
精製水 合計で100となる量
D部
製造例1のイヌリン組成物 2.0
Tremoist-TP(日本精化) 0.1
精製水 10.0
-------------------------------------
(調製方法)
A部、C部をそれぞれ混合し、約70℃に加温し、均一に溶解、分散させた。B部を混合し、攪拌して粘性の液とした。D部を混合し、均一な液とした。C部をホモミキサーにて攪拌しながらA部を加えて乳化した。冷却し約50℃にて、B部、D部を加え、攪拌して約40℃まで冷却した。
(Example 23)
skin care cream
Component Amount (wt%)
------------------------------------
Part A Mineral oil 8.0
Plandool-MAS (Nippon Fine Chemical) 2.0
Plandool-LG1 (Nippon Fine Chemical) 1.0
paraffin wax 3.0
shea butter 3.0
Squalane 8.0
Setanol 1.8
Hydrogenated cocoglyceryl 0.8
Glyceryl stearate 1.0
Behenyl alcohol 1.5
Sorbitan stearate 1.0
Methylglucose sesquistearate 1.5
Part B Xanthan gum 0.1
Hydroxyethylcellulose 0.1
Crystalline cellulose powder 0.3
Stearoxyhydroxypropyl methylcellulose 0.1
Purified water 20.0
Part C Glycerin 8.0
DPG 5.0
Sorbitol 2.0
Methylparaben 0.15
Purified water Total amount of 100 Part D Inulin composition of Production Example 1 2.0
Tremoist-TP (Nippon Fine Chemical) 0.1
Purified water 10.0
------------------------------------
(Preparation method)
Part A and Part C were mixed and heated to about 70°C to uniformly dissolve and disperse. Part B was mixed and stirred to form a viscous liquid. Part D was mixed to form a homogeneous liquid. While stirring part C with a homomixer, part A was added and emulsified. After cooling to about 50°C, parts B and D were added, stirred, and cooled to about 40°C.
(実施例24)
スキンケアクリーム
成 分 配合量(重量%)
--------------------------------------
A部
グリセリン 9.0
Phytocompo-C(日本精化) 1.0
グルコシルルチン 0.001
B部
アルガニアスピノサ核油 1.0
テオブロマグランジフロルム種子脂 1.0
アスタキサンチン 0.005
テトラエチルヘキサン酸ペンタエリスリチル
(NS-408:日本精化) 0.1
ステアリン酸エチルヘキシル 3.0
Plandool-ISS(日本精化) 2.0
カルナウバロウ 0.5
ステアレス-2 2.5
ステアレス-21 1.8
セタノール 3.0
酢酸トコフェロール 0.03
スクワラン 6.0
C部
カルボマー 0.1
アルギニン 0.1
ヒドロキシプロピルキトサン 0.2
エタノール 3.0
精製水 10.0
パンテノール 0.5
パルミチン酸レチノール 0.05
D部
メチルパラベン 0.15
精製水 合計で100となる量
E部
実施例12の組成物 5.0
--------------------------------------
(調製方法)
A部、B部、D部をそれぞれ混合し、約70℃に加温し、均一に溶解、分散させた。C部を混合し、攪拌して粘性の液とした。A部をホモディスパーにて攪拌しながらB部を加えた後、D部を加えて乳化した。冷却し約50℃にて、C部、E部を加え、攪拌して約40℃まで冷却した。
(Example 24)
skin care cream
Component Amount (wt%)
--------------------------------------
Part A Glycerin 9.0
Phytocompo-C (Nippon Fine Chemical) 1.0
Glucosylrutin 0.001
Part B Argania spinosa kernel oil 1.0
Theobroma Grange Florum Seed Oil 1.0
Astaxanthin 0.005
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical) 0.1
Ethylhexyl stearate 3.0
Plandool-ISS (Nippon Fine Chemical) 2.0
Carnauba wax 0.5
Steerless-2 2.5
Steares-21 1.8
Setanol 3.0
Tocopherol acetate 0.03
Squalane 6.0
Part C Carbomer 0.1
Arginine 0.1
Hydroxypropyl chitosan 0.2
Ethanol 3.0
Purified water 10.0
Panthenol 0.5
Retinol palmitate 0.05
Part D Methylparaben 0.15
Purified water Amount E parts totaling 100 Composition of Example 12 5.0
--------------------------------------
(Preparation method)
Part A, Part B, and Part D were mixed and heated to about 70°C to uniformly dissolve and disperse. Part C was mixed and stirred to form a viscous liquid. Part B was added to part A while stirring with a homodisper, and then part D was added and emulsified. After cooling to about 50°C, parts C and E were added, stirred, and cooled to about 40°C.
(実施例25)
スキンケアクリーム
成 分 配合量(重量%)
-------------------------------------
A部
グリセリン 12.0
BG 6.0
Phytocompo-PP(日本精化) 2.5
B部
ミネラルオイル 3.0
オリーブ果実油 3.0
オリーブ油 1.5
シア脂 1.0
Plandool-S(日本精化) 1.0
テトラエチルヘキサン酸ペンタエリスリチル
(NS-408:日本精化) 3.0
ステアリン酸スクロース 0.8
セテアリルグルコシド 1.2
ベヘニルアルコール 1.5
テトラヘキシルデカン酸アスコルビル 7.0
ラウロイルサルコシンイソプロピル 2.0
水添ココグリセリル 3.0
セタノール 2.5
ステアリン酸ソルビタン 0.8
C部
キサンタンガム 0.05
チューベロース多糖体 0.01
水溶性コラーゲン 0.05
加水分解コラーゲン 0.5
ピロ亜硫酸Na 0.03
D部
Neosolue-Aqulio(日本精化) 1.0
プロパンジオール 3.0
メチルパラベン 0.1
精製水 合計で100となる量
E部
製造例1のイヌリン組成物 3.0
Tremoist-TP(日本精化) 0.02
精製水 10.0
---------------------------------------(調製方法)
A部、B部、D部をそれぞれ混合し、約70℃に加温し、均一に溶解、分散させた。C部を混合し、攪拌して粘性の液とした。E部を混合し、均一な液とした。A部をホモディスパーにて攪拌しながらB部を加えた後、D部を加えて乳化した。冷却し約50℃にて、C部、E部を加え、攪拌して約40℃まで冷却した。
(Example 25)
skin care cream
Component Amount (wt%)
------------------------------------
Part A Glycerin 12.0
BG 6.0
Phytocompo-PP (Nippon Fine Chemical) 2.5
Part B Mineral oil 3.0
Olive fruit oil 3.0
olive oil 1.5
Shea butter 1.0
Plandool-S (Nippon Fine Chemical) 1.0
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical) 3.0
Sucrose stearate 0.8
Cetearyl glucoside 1.2
Behenyl alcohol 1.5
Ascorbyl tetrahexyldecanoate 7.0
Lauroylsarcosine isopropyl 2.0
Hydrogenated cocoglyceryl 3.0
Setanol 2.5
Sorbitan stearate 0.8
Part C Xanthan gum 0.05
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
Sodium pyrosulfite 0.03
D part Neosolue-Aqulio (Nippon Fine Chemical) 1.0
Propanediol 3.0
Methylparaben 0.1
Purified water Quantity E parts totaling 100 Inulin composition of Production Example 1 3.0
Tremoist-TP (Nippon Fine Chemical) 0.02
Purified water 10.0
---------------------------------------(Preparation method)
Part A, Part B, and Part D were mixed and heated to about 70°C to uniformly dissolve and disperse. Part C was mixed and stirred to form a viscous liquid. Part E was mixed to form a homogeneous solution. Part B was added to part A while stirring with a homodisper, and then part D was added and emulsified. After cooling to about 50°C, parts C and E were added, stirred, and cooled to about 40°C.
(実施例26)
ハンドクリーム
成 分 配合量(重量%)
---------------------------------
A部
リンゴ酸ジイソステアリル 8.0
ラノリン脂肪酸コレステリル
(YOFCO CLE-S:日本精化) 5.0
LUSPLAN SR-DM4(日本精化) 0.1
スクワラン 8.0
マカデミアナッツ油 0.5
ローズヒップ油 1.0
メドウフォーム油 1.0
ワセリン 15.0
マイクロクリスタリンワックス 2.0
ステアリン酸グリセリル 2.0
セタノール 2.0
リン酸セチル 1.0
ミツロウ 3.0
プロピルパラベン 0.1
トコフェロール 0.05
パーフルオロポリエーテル 1.0
B部
グリセリン 8.0
プロパンジオール 5.0
メチルパラベン 0.1
エチルヘキシルグリセリン 0.5
フェノキシエタノール 0.3
水酸化Na 0.5
水 合計で100となる量
C部
実施例12の組成物 3.0
---------------------------------
(調製方法)
B部を約70℃に加温し溶解させた。別の容器にA部をとり、約80℃に加温し溶解させた。B部にA部をホモミキサーで攪拌しながら添加し乳化した。乳化後、約40℃まで冷却後、C部を加え、均一に混合した。
(Example 26)
hand cream
Component Amount (wt%)
---------------------------------
Part A Diisostearyl malate 8.0
Lanolin fatty acid cholesteryl (YOFCO CLE-S: Nippon Fine Chemical) 5.0
LUSPLAN SR-DM4 (Nippon Fine Chemical) 0.1
Squalane 8.0
Macadamia nut oil 0.5
rosehip oil 1.0
meadowfoam oil 1.0
Vaseline 15.0
Microcrystalline wax 2.0
Glyceryl stearate 2.0
Setanol 2.0
Cetyl phosphate 1.0
Beeswax 3.0
Propylparaben 0.1
Tocopherol 0.05
Perfluoropolyether 1.0
Part B Glycerin 8.0
Propanediol 5.0
Methylparaben 0.1
Ethylhexylglycerin 0.5
Phenoxyethanol 0.3
Na hydroxide 0.5
Water Amount C totaling 100 Composition of Example 12 3.0
---------------------------------
(Preparation method)
Part B was heated to about 70°C and dissolved. Part A was placed in a separate container and heated to about 80°C to dissolve it. Part A was added to part B while stirring with a homomixer and emulsified. After emulsification and cooling to about 40° C., part C was added and mixed uniformly.
(実施例27)
ハンドクリーム
成 分 配合量(重量%)
---------------------------------
A部
ワセリン 5.0
Plandool-G(日本精化) 0.5
(ジメチコン/ビニルジメチコン)クロスポリマー 0.3
(ビニルジメチコン/ラウリルジメチコン)クロスポリマー 0.5
(ジメチコン/PEG-10/15)クロスポリマー 0.5
(PEG-15/ラウリルジメチコン)クロスポリマー 0.2
(アクリル酸アルキル/ジメチコン)コポリマー 0.1
エチルヘキサン酸セチル(NS-CIO:日本精化) 10.0
プロピルパラベン 0.1
スクワラン 5.0
B部
ジグリセリン 5.0
メチルパラベン 0.1
C部
キサンタンガム(2%水溶液) 10.0
(アクリルアミド/アクリル酸アンモニウム)コポリマー 0.5
水 合計で100となる量
D部
実施例12の組成物 8.0
---------------------------------
(調製方法)
B部を溶解させた後、A部を加え、約70℃に加温した(E部)。C部を約70℃にした。E部にC部を攪拌しながら加え、約3分間ホモミキサーで攪拌、混合した。約40℃まで冷却した後、混合したD部を加え、均一に混合した。
(Example 27)
hand cream
Component Amount (weight%)
---------------------------------
Part A Vaseline 5.0
Plandool-G (Nippon Fine Chemical) 0.5
(Dimethicone/vinyl dimethicone) crosspolymer 0.3
(vinyl dimethicone/lauryl dimethicone) crosspolymer 0.5
(Dimethicone/PEG-10/15) Crosspolymer 0.5
(PEG-15/lauryl dimethicone) crosspolymer 0.2
(Alkyl acrylate/dimethicone) copolymer 0.1
Cetyl ethylhexanoate (NS-CIO: Nippon Fine Chemical) 10.0
Propylparaben 0.1
Squalane 5.0
Part B Diglycerin 5.0
Methylparaben 0.1
Part C Xanthan gum (2% aqueous solution) 10.0
(acrylamide/ammonium acrylate) copolymer 0.5
Water Amount D totaling 100 Composition of Example 12 8.0
---------------------------------
(Preparation method)
After dissolving part B, part A was added and heated to about 70°C (part E). Part C was brought to about 70°C. Part C was added to Part E with stirring, and the mixture was stirred and mixed using a homomixer for about 3 minutes. After cooling to about 40° C., mixed Part D was added and mixed uniformly.
(実施例28)
ハンドクリーム
成 分 配合量(重量%)
---------------------------------
A部
スクワラン 10.0
ワセリン 20.0
ペンタステアリン酸ポリグリセリル-10 2.0
マイクロクリスタリンワックス 4.0
ステアロイル乳酸Na 1.3
ステアリン酸Al 1.5
ステアリン酸Mg 1.0
ステアリン酸Ca 0.1
B部
LUSPLAN PI-DA(日本精化) 5.0
Plandool-MAS(日本精化) 1.0
Plandool-DP(日本精化) 0.8
エチルヘキサン酸セチル(NS-CIO:日本精化) 5.0
トリエチルヘキサノイン(IOTG:日本精化) 6.0
プロピルパラベン 0.05
トコフェロール 0.05
シクロペンタシロキサン 5.0
C部
メチルパラベン 0.1
グリセリン 10.0
水 合計で100となる量
D部
実施例12の組成物 10.0
---------------------------------
(調製方法)
B部、C部それぞれを約80℃に加温し溶解させた。別の容器にA部をとり、100~120℃に加温、透明ゲル化し80℃まで冷却した。A部にB部を攪拌しながら加え、さらにC部を加え乳化した。約40℃まで冷却した後、混合したD部を加え、均一に混合した。
(Example 28)
hand cream
Component Amount (wt%)
---------------------------------
Part A Squalane 10.0
Vaseline 20.0
Polyglyceryl pentasteate-10 2.0
Microcrystalline wax 4.0
Sodium stearoyl lactate 1.3
Al stearate 1.5
Mg stearate 1.0
Ca stearate 0.1
Part B LUSPLAN PI-DA (Nippon Fine Chemical) 5.0
Plandool-MAS (Nippon Fine Chemical) 1.0
Plandool-DP (Nippon Fine Chemical) 0.8
Cetyl ethylhexanoate (NS-CIO: Nippon Fine Chemical) 5.0
Triethylhexanoin (IOTG: Nippon Fine Chemical) 6.0
Propylparaben 0.05
Tocopherol 0.05
Cyclopentasiloxane 5.0
Part C Methylparaben 0.1
Glycerin 10.0
Water Amount D totaling 100 Composition of Example 12 10.0
---------------------------------
(Preparation method)
Part B and Part C were each heated to about 80°C and dissolved. Part A was placed in a separate container, heated to 100 to 120°C to form a transparent gel, and cooled to 80°C. Part B was added to Part A with stirring, and Part C was further added to emulsify. After cooling to about 40° C., mixed Part D was added and mixed uniformly.
(実施例29)
乳液
成 分 配合量(重量%)
----------------------------------
A部
Phytocompo-SP(日本精化) 8.0
LP70H(日本精化) 0.1
B部
LUSPLAN SR-DM4(日本精化) 5.0
スクワラン 4.0
Neosolue-MCT(日本精化) 4.0
α-オレフィンオリゴマー 2.5
シクロペンタシロキサン 3.5
セタノール 1.5
ステアリン酸グリセリル 1.0
C部
ヒドロキシプロリン 0.05
クエン酸 0.01
クエン酸Na 0.09
フェノキシエタノール 0.3
メチルパラベン 0.1
アクリル酸・メタクリル酸アルキル共重合体 0.1
水酸化K 0.1
精製水 合計で100となる量
D部
製造例1のイヌリン組成物 1.5
Tremoist-TP(日本精化) 0.01
精製水 10.0
-----------------------------------
(調製方法)
A部~C部をそれぞれとり、約70℃に加温し、それぞれ均一に混合した。A部にB部をホモディスパーで攪拌しながら徐々に加えた後、約70℃でC部を加え乳化した。約40℃まで冷却した後、混合したD部を加え、均一に混合した。
(Example 29)
emulsion
Component Amount (wt%)
----------------------------------
Part A Phytocompo-SP (Nippon Fine Chemical) 8.0
LP70H (Nippon Fine Chemical) 0.1
Part B LUSPLAN SR-DM4 (Nippon Fine Chemical) 5.0
Squalane 4.0
Neosolue-MCT (Nippon Fine Chemical) 4.0
α-olefin oligomer 2.5
Cyclopentasiloxane 3.5
Setanol 1.5
Glyceryl stearate 1.0
Part C Hydroxyproline 0.05
Citric acid 0.01
Sodium citrate 0.09
Phenoxyethanol 0.3
Methylparaben 0.1
Acrylic acid/alkyl methacrylate copolymer 0.1
Hydroxide K 0.1
Purified water Total amount of 100 Part D Inulin composition of Production Example 1 1.5
Tremoist-TP (Nippon Fine Chemical) 0.01
Purified water 10.0
-----------------------------------
(Preparation method)
Parts A to C were each taken, heated to about 70°C, and mixed uniformly. Part B was gradually added to part A while stirring with a homodisper, and then part C was added and emulsified at about 70°C. After cooling to about 40° C., mixed Part D was added and mixed uniformly.
(実施例30)
ジェル化粧水
成 分 配合量(重量%)
------------------------------------
A部
Phytocompo-PP(日本精化) 0.5
グリセリン 5.0
ソルビトール液(70%) 5.0
ベヘン酸グリセリル 0.8
ステアリン酸 0.3
PEG-20水添ヒマシ油 0.1
オレイン酸ポリグリセリル-10 0.1
B部
フェノキシエタノール 0.3
プルラン 0.2
エチルヘキシルグリセリン 0.2
ポリHEMAグルコシド 0.05
ポリメタクリロイルリシン 0.05
結晶セルロース末 0.1
ローカストビーンガム 0.03
ヒドロキシエチルセルロース 0.05
ヒアルロン酸Na 0.01
カルボマー 0.06
水酸化K 0.05
精製水 合計で100となる量
C部
製造例1のイヌリン組成物 2.5
Tremoist-TP(日本精化) 0.005
精製水 10.0
-------------------------------------
(調製方法)
A部を約70℃に加温し、均一に分散させた。B部を混合、よく攪拌し、均一にしたのち約70℃に加温した。A部にB部を加え、約70℃でホモミキサーを用い撹拌し、約40℃まで冷却した。混合したC部を加え、均一に混合した。
(Example 30)
gel lotion
Component Amount (wt%)
------------------------------------
Part A Phytocompo-PP (Nippon Fine Chemical) 0.5
glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl behenate 0.8
Stearic acid 0.3
PEG-20 hydrogenated castor oil 0.1
Polyglyceryl oleate-10 0.1
Part B Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexylglycerin 0.2
PolyHEMA glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust Bean Gum 0.03
Hydroxyethylcellulose 0.05
Hyaluronate Na 0.01
Carbomer 0.06
Hydroxide K 0.05
Purified water Amount that makes the total 100 Part C Inulin composition of Production Example 1 2.5
Tremoist-TP (Nippon Fine Chemical) 0.005
Purified water 10.0
------------------------------------
(Preparation method)
Part A was heated to about 70°C and uniformly dispersed. Part B was mixed and stirred well to make the mixture uniform, and then heated to about 70°C. Part B was added to Part A, stirred at about 70°C using a homomixer, and cooled to about 40°C. Mixed part C was added and mixed uniformly.
(実施例31)
クレンジングジェル
成 分 配合量(重量%)
---------------------------------
A部
エチルヘキサン酸セチル(NS-CIO:日本精化) 10.0
Plandool-S(日本精化) 1.0
ジヒドロコレス-3(ベルポールDC-30:日本精化) 2.0
LUSPLAN DD-IS(日本精化) 8.0
PEG-25水添ヒマシ油 20.0
オクチルドデセス-20 15.0
グリセリン 16.0
BG 5.0
B部
フェノキシエタノール 0.5
精製水 合計で100となる量
C部
実施例12の組成物 5.0
---------------------------------
(調製方法)
A部、B部をそれぞれ約80℃に加温して溶解した。混合し、約80℃に加温した。攪拌しながらA部にB部を徐々に加え、混合後40℃まで冷却した。C部を加え、均一に混合した。
(Example 31)
cleansing gel
Component Amount (wt%)
---------------------------------
Part A Cetyl ethylhexanoate (NS-CIO: Nippon Fine Chemical) 10.0
Plandool-S (Nippon Fine Chemical) 1.0
Dihydrocholace-3 (Bellpol DC-30: Nippon Fine Chemical) 2.0
LUSPLAN DD-IS (Nippon Fine Chemical) 8.0
PEG-25 hydrogenated castor oil 20.0
Octyldecess-20 15.0
Glycerin 16.0
BG5.0
Part B Phenoxyethanol 0.5
Purified water Amount that makes the total 100 Part C Composition of Example 12 5.0
---------------------------------
(Preparation method)
Part A and Part B were each heated to about 80°C and dissolved. Mix and warm to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C. Part C was added and mixed uniformly.
(実施例32)
クレンジングクリーム
成 分 配合量(重量%)
---------------------------------
A部
Neosolue-DE(日本精化) 5.0
グリセリン 3.0
Plandool-LG2(日本精化) 1.0
Neosolue-Aqulio(日本精化) 1.0
セレシン 6.0
ミネラルオイル 28.0
イソステアリン酸PEG-12 3.0
セスキオレイン酸ソルビタン 1.5
オレイン酸ポリオキシエチレンソルビタン 0.3
マイクロクリスタリンワックス 2.0
トコフェロール 0.05
プロピルパラベン 0.05
B部
DPG 5.0
メチルパラベン 0.2
エデト酸3Na 0.02
フェノキシエタノール 0.2
精製水 合計で100となる量
C部
実施例12の組成物 1.0
---------------------------------
(調製方法)
A部、B部をそれぞれ約80℃に加温して溶解した。混合し、約80℃に加温した。攪拌しながらA部にB部を徐々に加え、混合後40℃まで冷却した。C部を加え、均一に混合した。
(Example 32)
Cleansing cream
Component Amount (wt%)
---------------------------------
Part A Neosolue-DE (Nippon Fine Chemical) 5.0
glycerin 3.0
Plandool-LG2 (Nippon Fine Chemical) 1.0
Neosolue-Aqulio (Nippon Fine Chemical) 1.0
Ceresin 6.0
Mineral oil 28.0
PEG-12 isostearate 3.0
Sorbitan sesquioleate 1.5
Polyoxyethylene sorbitan oleate 0.3
Microcrystalline wax 2.0
Tocopherol 0.05
Propylparaben 0.05
Part B DPG 5.0
Methylparaben 0.2
Edetate trisodium 0.02
Phenoxyethanol 0.2
Purified water Amount that makes the total 100 Part C Composition of Example 12 1.0
---------------------------------
(Preparation method)
Part A and Part B were each heated to about 80°C and dissolved. Mix and warm to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C. Part C was added and mixed uniformly.
(実施例33)
洗顔フォーム
成 分 配合量(重量%)
-----------------------------------
A部
ステアリン酸K 10.0
パルミチン酸K 10.0
ミリスチン酸K 10.0
ラウリン酸K 4.0
ラウロイルサルコシンイソプロピル 0.8
PEG1500 10.0
グリセリン 15.0
モノステアリン酸グリセリル 1.0
POE(20)ソルビタンモノステアレート 2.0
B部
ポリクオタニウム-7 0.5
ポリクオタニウム-39 0.5
メチルパラベン 0.1
精製水 合計で100となる量
C部
実施例12の組成物 5.0
-----------------------------------
(調製方法)
A部を約80℃に加温して溶解した。B部を約80℃に加温した。攪拌しながらA部にB部を徐々に加え、混合後40℃まで冷却した。C部を加えて、均一に混合した。
(Example 33)
facial cleansing foam
Component Amount (wt%)
-----------------------------------
Part A Stearic acid K 10.0
Palmitic acid K 10.0
Myristic acid K 10.0
Lauric acid K 4.0
Lauroylsarcosine isopropyl 0.8
PEG1500 10.0
Glycerin 15.0
Glyceryl monostearate 1.0
POE (20) Sorbitan Monostearate 2.0
Part B Polyquaternium-7 0.5
Polyquaternium-39 0.5
Methylparaben 0.1
Purified water Amount that makes the total 100 Part C Composition of Example 12 5.0
-----------------------------------
(Preparation method)
Part A was heated to about 80°C and dissolved. Part B was heated to about 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C. Part C was added and mixed uniformly.
(実施例34)
洗顔フォーム
成 分 配合量(重量%)
---------------------------------
A部
(ヤシ脂肪酸/水添牛脂脂肪酸)グルタミン酸Na 30.0
ココイルグリシンK 5.0
Plandool-LG2(日本精化) 0.2
ラウリン酸ジエタノールアミド 3.0
トコフェロール 0.1
PEG-8 5.0
PEG-32 10.0
グリセリン 14.0
プロピルパラベン 0.1
B部
メチルパラベン 0.2
ポリクオタニウム-51 1.0
結晶セルロース 0.3
ポリクオタニウム-7 0.8
精製水 合計で100となる量
C部
製造例1のイヌリン組成物 4.0
Tremoist-TP(日本精化) 0.02
精製水 10.0
---------------------------------
(調製方法)
A部を約80℃に加温して溶解した。B部を約80℃に加温する。攪拌しながらA部にB部を徐々に加え、混合後40℃まで冷却した。C部を加えて、均一に混合した。
(Example 34)
facial cleansing foam
Component Amount (wt%)
---------------------------------
Part A (coconut fatty acid/hydrogenated beef tallow fatty acid) Sodium glutamate 30.0
Cocoylglycine K 5.0
Plandool-LG2 (Nippon Fine Chemical) 0.2
Lauric acid diethanolamide 3.0
Tocopherol 0.1
PEG-8 5.0
PEG-32 10.0
Glycerin 14.0
Propylparaben 0.1
Part B Methylparaben 0.2
Polyquaternium-51 1.0
Crystalline cellulose 0.3
Polyquaternium-7 0.8
Purified water Amount that makes the total 100 Part C Inulin composition of Production Example 1 4.0
Tremoist-TP (Nippon Fine Chemical) 0.02
Purified water 10.0
---------------------------------
(Preparation method)
Part A was heated to about 80°C and dissolved. Part B is heated to approximately 80°C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40°C. Part C was added and mixed uniformly.
(実施例35)
ボディシャンプー
成 分 配合量(重量%)
---------------------------------
A部
ヤシ脂肪酸K、ミリスチン酸K 10.0
ココイルメチルタウリンNa 1.5
コカミドDEA 5.0
EDTA-2Na 0.1
濃グリセリン 10.0
コカミドプロピルベタイン 5.0
フェノキシエタノール 0.4
精製水 合計で100となる量
B部
実施例12の組成物 10.0
---------------------------------
(調製方法)
A部を約80℃で加温して均一に攪拌混合した。約40℃に冷却し、B部を加えて、均一に混合した。
(Example 35)
body shampoo
Component Amount (wt%)
---------------------------------
Part A Coconut fatty acid K, myristic acid K 10.0
Cocoyl methyl taurine Na 1.5
Cocamide DEA 5.0
EDTA-2Na 0.1
Concentrated glycerin 10.0
Cocamidopropyl betaine 5.0
Phenoxyethanol 0.4
Purified water Total amount of 100 Part B Composition of Example 12 10.0
---------------------------------
(Preparation method)
Part A was heated to about 80° C. and stirred and mixed uniformly. It was cooled to about 40° C., Part B was added and mixed uniformly.
(実施例36)
ボディシャンプー
成 分 配合量(重量%)
---------------------------------
A部
ココイルメチルタウリンNa 10.0
ラウロイル加水分解シルクNa 6.0
ラウロイルメチルアラニンNa 10.0
ココアンホ酢酸Na(30%) 4.0
コカミドプロピルベタイン(30%) 10.0
オレフィン(C14-16)スルホン酸Na 5.0
ポリクオタニウム-10 1.3
グアーヒドロキシプロピルトリモニウムクロリド 0.8
アセチルヒアルロン酸Na 0.02
コカミドDEA 3.0
グリセリン 5.0
メチルパラベン 0.2
精製水 合計で100となる量
B部
製造例1のイヌリン組成物 0.5
Tremoist-TP(日本精化) 0.02
精製水 10.0
---------------------------------
(調製方法)
A部を約80℃で加温して均一に攪拌混合した。約40℃に冷却し、B部を加えて、均一に混合した。
(Example 36)
body shampoo
Component Amount (wt%)
---------------------------------
Part A Cocoyl methyl taurine Na 10.0
Lauroyl hydrolyzed silk Na 6.0
Lauroyl methylalanine Na 10.0
Sodium Cocoamphoacetate (30%) 4.0
Cocamidopropyl betaine (30%) 10.0
Olefin (C14-16) sulfonic acid Na 5.0
Polyquaternium-10 1.3
Guar hydroxypropyltrimonium chloride 0.8
Acetyl hyaluronate Na 0.02
Cocamide DEA 3.0
glycerin 5.0
Methylparaben 0.2
Purified water Total amount of 100 Part B Inulin composition of Production Example 1 0.5
Tremoist-TP (Nippon Fine Chemical) 0.02
Purified water 10.0
---------------------------------
(Preparation method)
Part A was heated to about 80° C. and stirred and mixed uniformly. It was cooled to about 40° C., Part B was added and mixed uniformly.
(実施例37)
ノンシリコーンシャンプー
成 分 配合量(重量%)
---------------------------------
A部
Plandool-LG2(日本精化) 0.03
Neosolue-AquaS(日本精化) 0.1
ラウレス-4カルボン酸Na(28%) 10.0
ラウレス-6カルボン酸 4.0
コカミドプロピルベタイン(30%) 10.0
ラウロイルメチルアラニンNa(30%) 5.0
コカミドメチルMEA 3.0
ヤシ油脂肪酸PEG-7グリセリル 5.0
水酸化Na 1%液 0.5
ポリクオタニウム-10 0.8
ジステアリン酸グリコール 0.5
ポリクオタニウム-7 0.5
EDTA-2Na 0.05
メチルパラベン 0.2
フェノキシエタノール 0.4
精製水 合計で100となる量
B部
実施例12の組成物 5.0
---------------------------------
(調製方法)
A部を約80℃で加温して均一に攪拌混合した。約40℃に冷却し、B部を加えて、均一に混合した。
(Example 37)
non-silicone shampoo
Component Amount (wt%)
---------------------------------
Part A Plandool-LG2 (Nippon Fine Chemical) 0.03
Neosolue-AquaS (Nippon Fine Chemical) 0.1
Sodium laureth-4 carboxylate (28%) 10.0
Laureth-6 carboxylic acid 4.0
Cocamidopropyl betaine (30%) 10.0
Lauroyl methylalanine Na (30%) 5.0
Cocamide methyl MEA 3.0
Coconut oil fatty acid PEG-7 glyceryl 5.0
Na hydroxide 1% solution 0.5
Polyquaternium-10 0.8
Glycol distearate 0.5
Polyquaternium-7 0.5
EDTA-2Na 0.05
Methylparaben 0.2
Phenoxyethanol 0.4
Purified water Total amount of 100 Part B Composition of Example 12 5.0
---------------------------------
(Preparation method)
Part A was heated to about 80° C. and stirred and mixed uniformly. It was cooled to about 40° C., Part B was added and mixed uniformly.
(実施例38)
ハンドソープ
成 分 配合量(重量%)
--------------------------------
A部
ココイルイセチオン酸Na 1.0
グリセリン 50.0
B部
ラウロイルサルコシン塩 12.0
ミリストイルメチルタウリンナトリウム 2.0
ラウリン酸ポリグリセリル-6 2.0
ヤシ油脂肪酸ジエタノールアミド 2.0
PEG-7ヤシ油脂肪酸グリセリル 2.0
合成ラテックス 0.1
ニトロセルロース 0.1
ソルビトール 8.0
コンキオリン分解ペプチド 0.1
1,3-ブチレングリコール 8.0
フェノキシエタノール 0.8
精製水 合計で100となる量
C部
製造例1のイヌリン組成物 1.5
Tremoist-TP(日本精化) 0.005
精製水 5.0
---------------------------------
(調製方法)
A部を約80℃に加温し溶解させた。A部にB部を加え、約80℃に加温し、均一溶解させた。約40℃に冷却し、C部を加えて、均一にした。
(Example 38)
hand soap
Component Amount (wt%)
--------------------------------
Part A Sodium cocoyl isethionate 1.0
Glycerin 50.0
Part B Lauroyl sarcosine salt 12.0
Myristoylmethyltaurate sodium 2.0
Polyglyceryl-6 laurate 2.0
Coconut oil fatty acid diethanolamide 2.0
PEG-7 coconut oil fatty acid glyceryl 2.0
Synthetic latex 0.1
Nitrocellulose 0.1
Sorbitol 8.0
Conchiolin degrading peptide 0.1
1,3-butylene glycol 8.0
Phenoxyethanol 0.8
Purified water Amount that makes the total 100 Part C Inulin composition of Production Example 1 1.5
Tremoist-TP (Nippon Fine Chemical) 0.005
Purified water 5.0
---------------------------------
(Preparation method)
Part A was heated to about 80°C and dissolved. Part B was added to part A and heated to about 80°C to uniformly dissolve it. Cool to about 40° C., add Part C and homogenize.
(実施例39)
洗い流さないヘアトリートメント
成 分 配合量(重量%)
-------------------------------------
A部
ポリクオタニウム-37 2.0
スクワラン 2.0
PPG-3カプリリルエーテル 2.0
マイクロクリスタリンワックス 0.1
ラノリンアルコール 0.2
モンタンワックス 0.1
ポリエチレンワックス 0.1
ミツロウ 0.1
モクロウ 0.2
セレシン 0.1
ジカプリン酸PG 1.0
アーモンド油 0.5
エチルへキサン酸エチルヘキシル 1.0
キャンデリラロウエキス 0.1
エルカ酸オクチルドデシル 4.5
酢酸トコフェロール 0.02
エルカラクトンMCT(日本精化) 2.0
トリポリヒドロキシステアリン酸ジペンタエリスリチル 1.5
PPG-5フィトステリル 0.5
グリセリン 4.0
ソルビトール 2.0
フェノキシエタノール 0.5
B部
加水分解コンキオリン 0.1
パンテノール 0.1
ヒアルロン酸ヒドロキシプロピルトリモニウム 0.01
ポリクオタニウム-11 0.2
グリコシルトレハロース 0.1
グリセリルグルコシド 0.3
アルギニン 0.1
C部
精製水 合計で100となる量
ヒドロキシプロピルデンプンリン酸 1.0
実施例12の組成物 3.0
--------------------------------------
(調製方法)
C部を均一に分散し、約80℃に加温した。次にA部を約80℃に加温し溶解させた。C部を攪拌しながらA部加え、均一に混合後、約40℃まで冷却させた。次いで、B部を加え、均一に混合した。
(Example 39)
No-rinse hair treatment
Component Amount (wt%)
------------------------------------
Part A Polyquaternium-37 2.0
Squalane 2.0
PPG-3 caprylyl ether 2.0
Microcrystalline wax 0.1
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Beeswax 0.1
Mokuro 0.2
Ceresin 0.1
Dicapric acid PG 1.0
Almond oil 0.5
Ethylhexyl ethylhexanoate 1.0
Candelilla wax extract 0.1
Octyldodecyl erucate 4.5
Tocopherol acetate 0.02
Ercalactone MCT (Nippon Fine Chemical) 2.0
Dipentaerythrityl tripolyhydroxystearate 1.5
PPG-5 phytosteryl 0.5
Glycerin 4.0
Sorbitol 2.0
Phenoxyethanol 0.5
Part B Hydrolyzed conchiolin 0.1
Panthenol 0.1
Hydroxypropyltrimonium hyaluronate 0.01
Polyquaternium-11 0.2
Glycosyltrehalose 0.1
Glyceryl glucoside 0.3
Arginine 0.1
Part C Purified water Amount to make a total of 100 Hydroxypropyl starch phosphate 1.0
Composition of Example 12 3.0
--------------------------------------
(Preparation method)
Part C was uniformly dispersed and heated to about 80°C. Next, part A was heated to about 80°C to dissolve it. Part A was added to part C while stirring, and after uniformly mixing, the mixture was cooled to about 40°C. Part B was then added and mixed uniformly.
(実施例40)
洗い流さないヘアトリートメント
成 分 配合量(重量%)
--------------------------------------
A部
セバシン酸ジエチルヘキシル
(Neosolue-EHS:日本精化) 4.0
Neosolue-Aqulio(日本精化) 1.0
セトリモニウムクロリド(25%) 2.8
ラノリンロウ 1.0
PPG-3カプリリルエーテル 1.0
ミリスチン酸メチルヘプチル 0.5
エチルヘキサン酸セチル(NS-CIO:日本精化) 0.3
イソノナン酸イソノニル 0.3
ネオペンタン酸トリデシル 0.5
イソオクタン酸ミリスチル 0.3
ジエチルヘキサン酸ネオペンチルグリコール 0.3
イソステアリン酸イソブチル 0.3
トリイソステアリン酸グリセリル 0.3
トリイソステアリン酸トリメチロールプロパン 0.3
ブロッコリー種子油 0.3
スフィンガニン 0.01
グリセリン 1.0
B部
メチルパラベン 0.1
精製水 合計で100となる量
フェノキシエタノール 0.5
C部
セラミド1、セラミド2、セラミド3、セラミド5、セラミド6、コレステロール、 クオタニウム-33含有組成物(NanoRepair-CMC5:日本精化)
5.0
γ-ドコサラクトン、ダイズステロール含有組成物
(NanoRepair-EL:日本精化) 1.0
ポリクオタニウム-6 0.6
ポリクオタニウム-7 0.4
ポリクオタニウム-39 0.5
D部
カラギーナン 0.1
ヒドロキシプロピルキトサン 0.05
ヒドロキシプロピルメチルセルロース 0.1
チューベロース多糖体 0.1
カチオン化グァーガム 0.05
精製水 20.0
E部
製造例1のイヌリン組成物 3.5
Tremoist-TP(日本精化) 0.005
精製水 10.0
--------------------------------------
(調製方法)
B部を約80℃に加温し、溶解させた。次にA部を約80℃に加温し溶解させた。D部を分散し、粘性の液とした。A部を攪拌しながらB部に加え、均一に混合後、約40℃まで冷却させた。次いでC部、D部、E部を加え、均一に混合した。
(Example 40)
No-rinse hair treatment
Component Amount (wt%)
--------------------------------------
Part A Diethylhexyl sebacate (Neosolue-EHS: Nippon Fine Chemical) 4.0
Neosolue-Aqulio (Nippon Fine Chemical) 1.0
Cetrimonium chloride (25%) 2.8
Lanolin Row 1.0
PPG-3 caprylyl ether 1.0
Methylheptyl myristate 0.5
Cetyl ethylhexanoate (NS-CIO: Nippon Fine Chemical) 0.3
Isononyl isononanoate 0.3
Tridecyl neopentanoate 0.5
Myristyl isooctanoate 0.3
Neopentyl glycol diethylhexanoate 0.3
Isobutyl isostearate 0.3
Glyceryl triisostearate 0.3
Trimethylolpropane triisostearate 0.3
Broccoli seed oil 0.3
Sphinganine 0.01
glycerin 1.0
Part B Methylparaben 0.1
Purified water Amount that makes a total of 100 Phenoxyethanol 0.5
Part C Ceramide 1, Ceramide 2, Ceramide 3, Ceramide 5, Ceramide 6, Cholesterol, Quaternium-33 containing composition (NanoRepair-CMC5: Nippon Fine Chemical)
5.0
Composition containing γ-docosalactone and soybean sterol (NanoRepair-EL: Nippon Fine Chemical) 1.0
Polyquaternium-6 0.6
Polyquaternium-7 0.4
Polyquaternium-39 0.5
Part D Carrageenan 0.1
Hydroxypropyl chitosan 0.05
Hydroxypropyl methylcellulose 0.1
Tuberose polysaccharide 0.1
Cationized guar gum 0.05
Purified water 20.0
Part E Inulin composition of Production Example 1 3.5
Tremoist-TP (Nippon Fine Chemical) 0.005
Purified water 10.0
--------------------------------------
(Preparation method)
Part B was heated to about 80°C and dissolved. Next, part A was heated to about 80°C to dissolve it. Part D was dispersed to form a viscous liquid. Part A was added to Part B while stirring, and after uniformly mixing, the mixture was cooled to about 40°C. Next, Part C, Part D, and Part E were added and mixed uniformly.
(実施例41)
洗い流さない頭皮/ヘアトリートメント
成 分 配合量(重量%)
--------------------------------------
A部
ミネラルオイル 3.0
Neosolue-Aqulio(日本精化) 1.0
エタノール 40.0
グリチルレチン酸 0.02
PPG-3カプリリルエーテル 0.3
エルカラクトンDES(日本精化) 1.5
PEG/PPG-20/20ジメチコン 0.2
PEG-12ジメチコン 0.4
水添レチノール 0.1
トリスヘキシルデカン酸ピリドキシン 0.05
ビスグリセリルアスコルビン酸 0.3
ヘキシル3-グリセリルアスコルビン酸 0.3
B部
トリエタノールアミン 0.1
精製水 合計で100となる量
(アクリレーツ/アクリル酸アルキル(C10-30))クロスポリマー 0.4
カルボマー 0.05
(アクリロイルジメチルタウリンアンモニウム/VP)コポリマー 0.05
(アクリロイルジメチルタウリンアンモニウム/メタクリル酸
ベヘネス-25)クロスポリマー 0.1
ヒドロキシプロピルキトサン 0.1
メチルパラベン 0.1
フェノキシエタノール 0.2
C部
VCエチル(日本精化) 0.05
ニコチンアミド 0.3
ピリドキシン塩酸塩 0.1
カフェイン 0.1
グルコシルトレハロース 0.1
精製水 10.0
D部
実施例12の組成物 6.0
----------------------------------------(調製方法)
A部を約50℃に加温し、溶解させた。次にB部を均一に分散し、粘性の液とした。A部を攪拌しながらB部に加え、均一に混合した。次いでC部、D部を加え、均一に混合した。
(Example 41)
Non-rinsing scalp/hair treatment
Component Amount (wt%)
--------------------------------------
Part A Mineral oil 3.0
Neosolue-Aqulio (Nippon Fine Chemical) 1.0
Ethanol 40.0
Glycyrrhetinic acid 0.02
PPG-3 caprylyl ether 0.3
Erucalactone DES (Nippon Fine Chemical) 1.5
PEG/PPG-20/20 Dimethicone 0.2
PEG-12 dimethicone 0.4
Hydrogenated retinol 0.1
Tris-hexyldecanoate pyridoxine 0.05
Bisglyceryl ascorbic acid 0.3
Hexyl 3-glyceryl ascorbic acid 0.3
Part B Triethanolamine 0.1
Purified water Amount that makes the total 100 (Acrylates/alkyl acrylate (C10-30)) Crosspolymer 0.4
Carbomer 0.05
(Acryloyldimethyltaurine ammonium/VP) copolymer 0.05
(Acryloyldimethyltaurine ammonium/methacrylic acid Behenes-25) Crosspolymer 0.1
Hydroxypropyl chitosan 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Part C VC ethyl (Nippon Fine Chemical) 0.05
Nicotinamide 0.3
Pyridoxine hydrochloride 0.1
Caffeine 0.1
Glucosyltrehalose 0.1
Purified water 10.0
Part D Composition of Example 12 6.0
----------------------------------------(Preparation method)
Part A was heated to about 50°C to dissolve it. Next, part B was uniformly dispersed to form a viscous liquid. Part A was added to part B while stirring and mixed uniformly. Next, Part C and Part D were added and mixed uniformly.
(実施例42)
ヘアトリートメント
成 分 配合量(重量%)
------------------------------------
A部
ドデカン 1.5
Neosolue-Aqulio(日本精化) 0.2
キャンデリラワックス 0.2
セチルエステルズ 0.3
エチルへキサン酸ステアリル 1.0
セテアリルアルコール 3.5
PEG-200 0.5
ヒドロキシエチルセルロース 0.4
セトリモニウムクロリド(30%) 1.0
ベヘントリモニウムクロリド(80%) 1.0
トリデセス-6 0.3
BHT 0.03
B部
メチルパラベン 0.2
クエン酸 0.05
精製水 合計で100となる量
C部
PPG-3ミリスチル 0.5
ネオペンタン酸イソデシル
(DUB VCI-10:日本精化) 1.0
D部
製造例1のイヌリン組成物 0.5
Tremoist-TP(日本精化) 0.02
精製水 10.0
-------------------------------------
(調製方法)
B部を約80℃に加温し溶解させた。別容器にA部を加え、加温し、溶解させた。A部にB部を徐々に加え、均一に混合した。約50℃でC部、D部を攪拌しながら添加し、均一にした。
(Example 42)
hair treatment
Component Amount (wt%)
------------------------------------
Part A Dodecane 1.5
Neosolue-Aqulio (Nippon Fine Chemical) 0.2
Candelilla wax 0.2
Cetyl esters 0.3
Stearyl ethylhexanoate 1.0
Cetearyl alcohol 3.5
PEG-200 0.5
Hydroxyethylcellulose 0.4
Cetrimonium chloride (30%) 1.0
Behentrimonium chloride (80%) 1.0
Trideceth-6 0.3
BHT 0.03
Part B Methylparaben 0.2
Citric acid 0.05
Purified water Amount that makes the total 100 Part C PPG-3 myristyl 0.5
Isodecyl neopentanoate (DUB VCI-10: Nippon Fine Chemical) 1.0
Part D Inulin composition of Production Example 1 0.5
Tremoist-TP (Nippon Fine Chemical) 0.02
Purified water 10.0
------------------------------------
(Preparation method)
Part B was heated to about 80°C and dissolved. Part A was added to a separate container, heated, and dissolved. Part B was gradually added to Part A and mixed uniformly. Parts C and D were added at about 50° C. with stirring and made uniform.
(実施例43)
ヘアトリートメント
成 分 配合量(重量%)
--------------------------------------
A部
Plandool-LG2(日本精化) 0.5
プロパンジオール 3.0
ベヘナミドプロピルジメチルアミン 1.5
セタノール 2.2
ステアリルアルコール 0.8
水添ナタネ油アルコール 0.5
ジエチルヘキサン酸ネオペンチルグリコール 0.8
ホホバ種子油 1.0
ステアリン酸グリセリル 0.4
プロピルパラベン 0.1
コカミドMEA 0.8
カエサルピニアスピノサヒドロキシプロピルトリモニウムクロリド 0.1
コメヌカワックス 0.5
グリセリン 1.0
B部
メチルパラベン 0.1
乳酸 0.4
精製水 合計で100となる量
C部
カプリル酸メチルヘプチル 1.0
ポリクオタニウム-7 0.15
ミリスチン酸PPG-3ベンジルエーテル 0.5
D部
製造例1のイヌリン組成物 3.0
Tremoist-TP(日本精化) 0.005
精製水 10.0
--------------------------------------
(調製方法)
A部を約80℃で均一に混合した。別にとっておいたB部を約60℃に加温、均一にした。A部にB部を攪拌しながら徐々に加え、均一に混合した後、約50℃まで冷却した。さらにC部、D部を加え均一に混合した。
(Example 43)
hair treatment
Component Amount (wt%)
--------------------------------------
Part A Plandool-LG2 (Nippon Fine Chemical) 0.5
Propanediol 3.0
Behenamidopropyldimethylamine 1.5
Setanol 2.2
Stearyl alcohol 0.8
Hydrogenated rapeseed oil alcohol 0.5
Neopentyl glycol diethylhexanoate 0.8
Jojoba seed oil 1.0
Glyceryl stearate 0.4
Propylparaben 0.1
Cocamide MEA 0.8
Caesarpinia Spinosa Hydroxypropyltrimonium Chloride 0.1
Rice bran wax 0.5
glycerin 1.0
Part B Methylparaben 0.1
Lactic acid 0.4
Purified water Amount to make a total of 100 Part C Methylheptyl caprylate 1.0
Polyquaternium-7 0.15
Myristic acid PPG-3 benzyl ether 0.5
Part D Inulin composition of Production Example 1 3.0
Tremoist-TP (Nippon Fine Chemical) 0.005
Purified water 10.0
--------------------------------------
(Preparation method)
Part A was uniformly mixed at about 80°C. Part B, which had been set aside, was heated to about 60° C. to make it uniform. Part B was gradually added to Part A with stirring, mixed uniformly, and then cooled to about 50°C. Furthermore, parts C and D were added and mixed uniformly.
(実施例44)
ノンシリコーンヘアトリートメント
成 分 配合量(重量%)
-----------------------------------
A部
LUSPLAN SR-DM4(日本精化) 0.8
Neosolue-MCT(日本精化) 0.6
ステアリルアルコール 2.0
セタノール 1.2
ステアルトリモニウムクロリド 1.0
PEG-45M 0.8
Plandool-LG1(日本精化) 0.3
トウツバキ種子油 0.4
ヒドロキシエチルウレア 0.5
炭酸ジカプリリル 2.0
PPG-1/PEG-1ステアラミン 1.0
スクワラン 0.1
イソセテス-10 0.5
ヒマワリワックス 0.8
ココイルアルギニンエチルPCA 0.2
フェノキシエタノール 0.2
トコフェロール 0.05
B部
DPG 2.2
グリセリン 1.3
ソルビトール 3.5
BG 1.0
ヒドロキシセルロース 0.07
フェノキシエタノール 0.2
クエン酸 適量
EDTA-2Na 0.01
精製水 合計で100となる量
C部
ポリクオタニウム-61 0.3
実施例12の組成物 5.0
-----------------------------------
(調製方法)
A部を約80℃で均一に混合した。別にとっておいたB部を約60℃に加温、均一にした。A部にB部を攪拌しながら徐々に加え、均一に混合した後、約50℃まで冷却した。さらにC部を加え均一に混合した。
(Example 44)
non-silicone hair treatment
Component Amount (wt%)
-----------------------------------
Part A LUSPLAN SR-DM4 (Nippon Fine Chemical) 0.8
Neosolue-MCT (Nippon Fine Chemical) 0.6
Stearyl alcohol 2.0
Setanol 1.2
Steartrimonium chloride 1.0
PEG-45M 0.8
Plandool-LG1 (Nippon Fine Chemical) 0.3
Camellia seed oil 0.4
Hydroxyethylurea 0.5
Dicaprylyl carbonate 2.0
PPG-1/PEG-1 stearamine 1.0
Squalane 0.1
Isocetes-10 0.5
sunflower wax 0.8
Cocoyl arginine ethyl PCA 0.2
Phenoxyethanol 0.2
Tocopherol 0.05
Part B DPG 2.2
Glycerin 1.3
Sorbitol 3.5
BG 1.0
Hydroxycellulose 0.07
Phenoxyethanol 0.2
Citric acid appropriate amount EDTA-2Na 0.01
Purified water Amount that makes the total 100 Part C Polyquaternium-61 0.3
Composition of Example 12 5.0
-----------------------------------
(Preparation method)
Part A was uniformly mixed at about 80°C. Part B, which had been set aside, was heated to about 60° C. to make it uniform. Part B was gradually added to Part A with stirring, mixed uniformly, and then cooled to about 50°C. Part C was further added and mixed uniformly.
(実施例45)
シャンプー
成 分 配合量(重量%)
------------------------------------
A部
ラウロイルメチルアラニンNa(30%) 13.0
コカミドプロピルベタイン(30%) 20.0
ココイルグルタミン酸TEA(30%) 5.0
コカミドDEA 1.0
グリセリン 1.0
カプリル酸グリセリル 0.4
ウンデシレン酸グリセリル 0.1
Neosolue-AquaS(日本精化) 1.0
ソルビトール 1.6
ジステアリン酸グリコール 1.5
ポリクオタニウム-7 0.3
B部
安息香酸Na 0.4
塩化Na 0.2
精製水 合計で100となる量
C部
センブリエキス 3.0
ポリクオタニウム-10 0.2
グアーヒドロキシプロピルトリモニウムクロリド 0.1
ポリクオタニウム-47 0.1
精製水 9.7
D部
製造例1のイヌリン組成物 1.0
Tremoist-TP(日本精化) 0.01
精製水 10.0
------------------------------------
(調製方法)
B部を約80℃に加温し均一に溶解させた。別容器にA部をとり、加温し、溶解させた。A部にB部を徐々に加え、均一に混合し、約60℃でC部を加えた。約40℃まで冷却し、D部を加え、均一に混合した。
(Example 45)
shampoo
Component Amount (wt%)
------------------------------------
Part A Lauroyl methylalanine Na (30%) 13.0
Cocamidopropyl betaine (30%) 20.0
Cocoyl glutamic acid TEA (30%) 5.0
Cocamide DEA 1.0
glycerin 1.0
Glyceryl caprylate 0.4
Glyceryl undecylenate 0.1
Neosolue-AquaS (Nippon Fine Chemical) 1.0
Sorbitol 1.6
Glycol distearate 1.5
Polyquaternium-7 0.3
Part B Sodium benzoate 0.4
Na chloride 0.2
Purified water Amount that makes a total of 100 Part C Assembly extract 3.0
Polyquaternium-10 0.2
Guar hydroxypropyltrimonium chloride 0.1
Polyquaternium-47 0.1
Purified water 9.7
Part D Inulin composition of Production Example 1 1.0
Tremoist-TP (Nippon Fine Chemical) 0.01
Purified water 10.0
------------------------------------
(Preparation method)
Part B was heated to about 80°C to uniformly dissolve it. Part A was placed in a separate container, heated, and dissolved. Part B was gradually added to Part A, mixed uniformly, and Part C was added at about 60°C. After cooling to about 40° C., Part D was added and mixed uniformly.
(実施例46)
シャンプー
成 分 配合量(重量%)
----------------------------------
A部
PPG-3カプリリルエーテル 0.2
ラウレス硫酸アンモニウム 5.0
ラウレス硫酸Na(25%) 10.0
ラウリルヒドロキシスルタイン(30%) 10.0
ラウリン酸K 1.0
ジステアリン酸グリコール 0.5
トルエンスルホン酸 0.3
ステアロキシプロピルジメチルアミン 0.5
PPG-17 0.3
ジメチコン 0.1
PEG-9ジメチコン 0.1
アモジメチコン 0.1
セバシン酸ジエチルヘキシル
(Neosolue-EHS:日本精化) 1.0
ジエチルヘキサン酸ネオペンチルグリコール 0.4
ラノリン脂肪酸 0.3
イソデシルグリセリルエーテル 0.4
硝酸ミコナゾール 0.75
コカミドMEA 1.0
ラウレス-4 0.3
ラウレス-16 0.2
ステアレス-6 0.2
フェノキシエタノール 0.3
B部
リンゴ酸 0.1
メチルパラベン 0.2
リン酸 0.03
安息香酸Na 0.3
精製水 合計で100となる量
C部
ポリクオタニウム-10 0.2
グアーヒドロキシプロピルトリモニウムクロリド 0.1
精製水 6.7
実施例12の組成物 5.0
----------------------------------
(調製方法)
A部を約80℃で均一に混合した。別にとっておいたB部を約60℃に加温、均一にした。A部にB部を攪拌しながら徐々に加え、均一に混合した後、約50℃まで冷却した。さらにC部を加え均一に混合した。
(Example 46)
shampoo
Component Amount (wt%)
----------------------------------
Part A PPG-3 caprylyl ether 0.2
Ammonium laureth sulfate 5.0
Sodium laureth sulfate (25%) 10.0
Lauryl hydroxysultaine (30%) 10.0
Lauric acid K 1.0
Glycol distearate 0.5
Toluenesulfonic acid 0.3
Stearoxypropyldimethylamine 0.5
PPG-17 0.3
Dimethicone 0.1
PEG-9 dimethicone 0.1
Amodimethicone 0.1
Diethylhexyl sebacate (Neosolue-EHS: Nippon Fine Chemical) 1.0
Neopentyl glycol diethylhexanoate 0.4
Lanolin fatty acid 0.3
Isodecyl glyceryl ether 0.4
Miconazole nitrate 0.75
Cocamide MEA 1.0
Laures-4 0.3
Laures-16 0.2
Steerless-6 0.2
Phenoxyethanol 0.3
Part B Malic acid 0.1
Methylparaben 0.2
Phosphoric acid 0.03
Sodium benzoate 0.3
Purified water Amount to make a total of 100 Part C Polyquaternium-10 0.2
Guar hydroxypropyltrimonium chloride 0.1
Purified water 6.7
Composition of Example 12 5.0
----------------------------------
(Preparation method)
Part A was uniformly mixed at about 80°C. Part B, which had been set aside, was heated to about 60° C. to make it uniform. Part B was gradually added to Part A with stirring, mixed uniformly, and then cooled to about 50°C. Part C was further added and mixed uniformly.
(実施例47)
ヘアトリートメント
成 分 配合量(重量%)
---------------------------------
A部
スクワラン 3.0
ベヘントリモニウムクロリド(80%) 2.4
セタノール 5.2
ステアリン酸グリセリル 1.2
セバシン酸ジエチルヘキシル
(Neosolue-EHS:日本精化) 0.4
シクロペンタシロキサン 0.8
ジメチコノール 0.1
B部
メチルパラベン 0.1
プロピルパラベン 0.1
精製水 合計で100となる量
C部
アミノエチルアミノプロピルシロキサン・
ジメチルシロキサン共重合体エマルション 2.0
D部
実施例12の組成物 5.0
ヒアルロン酸Na 0.001
---------------------------------
(調製方法)
A部、B部をそれぞれとり、約80℃に加温し、それぞれ均一に混合した。A部にB部を攪拌しながら徐々に加え、均一に混合した後、冷却した(D部)。D部にC部を加え均一に混合した。
(Example 47)
hair treatment
Component Amount (wt%)
---------------------------------
Part A Squalane 3.0
Behentrimonium chloride (80%) 2.4
Setanol 5.2
Glyceryl stearate 1.2
Diethylhexyl sebacate (Neosolue-EHS: Nippon Fine Chemical) 0.4
Cyclopentasiloxane 0.8
Dimethiconol 0.1
Part B Methylparaben 0.1
Propylparaben 0.1
Purified water Amount to make a total of 100 Part C Aminoethylaminopropylsiloxane
Dimethylsiloxane copolymer emulsion 2.0
Part D Composition of Example 12 5.0
Hyaluronate Na 0.001
---------------------------------
(Preparation method)
Parts A and B were each taken, heated to about 80°C, and mixed uniformly. Part B was gradually added to Part A with stirring, mixed uniformly, and then cooled (Part D). Part C was added to Part D and mixed uniformly.
(実施例48)
リーブオンヘアトリートメント
成 分 配合量(重量%)
----------------------------------
A部
Neosolue-Aqulio(日本精化) 2.0
セトリモニウムクロリド(25%) 3.8
カプリリルグルコシド(50%) 0.8
グリセリン 4.0
フェノキシエタノール 0.5
B部
エタノール 5.0
C部
ポリクオタニウム-6 0.6
ポリクオタニウム-7 0.4
ポリクオタニウム-39 0.5
精製水 合計で100となる量
D部
製造例1のイヌリン組成物 0.5
Tremoist-TP(日本精化) 0.005
精製水 10.0
----------------------------------
(調製方法)
C部を約80℃に加温し、溶解させた。次にA部を約80℃に加温し溶解させた。C部を攪拌しながらA部加え、均一に混合後、約40℃まで冷却させた。次いで、B部、D部を加え、均一に混合させた。
(Example 48)
leave-on hair treatment
Component Amount (wt%)
----------------------------------
Part A Neosolue-Aqulio (Nippon Fine Chemical) 2.0
Cetrimonium chloride (25%) 3.8
Caprylyl glucoside (50%) 0.8
Glycerin 4.0
Phenoxyethanol 0.5
Part B Ethanol 5.0
Part C Polyquaternium-6 0.6
Polyquaternium-7 0.4
Polyquaternium-39 0.5
Purified water Total amount of 100 Part D Inulin composition of Production Example 1 0.5
Tremoist-TP (Nippon Fine Chemical) 0.005
Purified water 10.0
----------------------------------
(Preparation method)
Part C was heated to about 80°C and dissolved. Next, part A was heated to about 80°C to dissolve it. Part A was added to part C while stirring, and after uniformly mixing, the mixture was cooled to about 40°C. Next, Part B and Part D were added and mixed uniformly.
(実施例49)
ムース
成 分 配合量(重量%)
---------------------------------
エタノール 5.0
ポリエチレングリコールオレイルエーテル(20) 1.0
アクリル樹脂アルカノールアミン液 3.0
ステアリン酸ジエチルアミノプロピルアミド 0.5
ピロリドンカルボン酸 0.2
防腐剤、香料 1.0
精製水 合計で100となる量
製造例1のイヌリン組成物 0.5
Tremoist-TP(日本精化) 0.005
精製水 10.0
---------------------------------
(調製方法)
以上の成分を混合し、得られたベースとLPGをベース:LPG=92:8の割合で混合し、噴射型ムースとした。
(Example 49)
mousse
Component Amount (wt%)
---------------------------------
Ethanol 5.0
Polyethylene glycol oleyl ether (20) 1.0
Acrylic resin alkanolamine liquid 3.0
Stearic acid diethylaminopropylamide 0.5
Pyrrolidone carboxylic acid 0.2
Preservatives, fragrances 1.0
Purified water Total amount of 100 Inulin composition of Production Example 1 0.5
Tremoist-TP (Nippon Fine Chemical) 0.005
Purified water 10.0
---------------------------------
(Preparation method)
The above components were mixed, and the obtained base and LPG were mixed at a ratio of base:LPG=92:8 to form a spray-type mousse.
(実施例50)
スタイリングミルク
成 分 配合量(重量%)
---------------------------------
A部
LUSPLAN SR-DM4(日本精化) 1.0
ステアリルアルコール 1.7
パルミチン酸イソプロピル
(Neosolue-IPP:日本精化) 1.2
ステアラミドプロピルジメチルアミン 1.0
Plandool-H(日本精化) 0.2
セテス-20 0.3
B部
フェノキシエタノール 0.4
乳酸 0.4
精製水 合計で100となる量
C部
ヒドロキシエチルセルロース 0.4
BG 2.0
D部
実施例12の組成物 3.0
---------------------------------
(調製方法)
A部、B部を約80℃でそれぞれ混合した。B部をA部に加え乳化し、約60℃に冷却後、C部を添加した。約40℃に冷却し、D部と混合し、均一にした。
(Example 50)
styling milk
Component Amount (weight%)
---------------------------------
Part A LUSPLAN SR-DM4 (Nippon Fine Chemical) 1.0
Stearyl alcohol 1.7
Isopropyl palmitate (Neosolue-IPP: Nippon Fine Chemical) 1.2
Stearamidopropyldimethylamine 1.0
Plandool-H (Nippon Fine Chemical) 0.2
Seteth-20 0.3
Part B Phenoxyethanol 0.4
Lactic acid 0.4
Purified water Amount that makes the total 100 Part C Hydroxyethyl cellulose 0.4
BG 2.0
Part D Composition of Example 12 3.0
---------------------------------
(Preparation method)
Parts A and B were mixed at about 80°C. Part B was added to part A and emulsified, and after cooling to about 60°C, part C was added. It was cooled to about 40° C., mixed with Part D, and homogenized.
(実施例51)
ヘアカラートリートメント
成 分 配合量(重量%)
--------------------------------------
A部
Neosolue-Aqulio(日本精化) 1.0
ステアルトリモニウムクロリド(70%) 2.5
クオタニウム-33(カチオンNH:日本精化) 0.3
コカミドDEA 1.0
ステアリン酸イヌリン 0.5
ラノリンアルコール 0.2
モンタンワックス 0.1
ポリエチレンワックス 0.1
ミツロウ 0.1
パルミチン酸デキストリン 0.3
セレシン 0.1
カプリン酸PPG-3 1.0
ジカプリン酸PG 1.0
エチルへキサン酸エチルヘキシル 1.0
炭酸ジカプリリル 1.5
グリセリン 4.0
セテス-7 1.0
イソステアリルアルコール 0.3
コメヌカ油 0.5
ステアリン酸グリセリル 0.5
エルカラクトンDES(日本精化) 1.5
水添ポリデセン 0.1
マカデミアナッツ脂肪酸エチル 1.0
ジラウロイルグルタミン酸リシンNa 0.1
ベヘンジモニウムエチルリン酸ステアリル 0.1
トコフェロール 0.05
フェノキシエタノール 0.3
C部
精製水 10.0
BG 2.0
アシル化加水分解コラーゲン 0.1
パンテノール 0.1
ヒドロキシエチルセルロース 0.1
ポリクオタニウム-64 0.1
ポリクオタニウム-51 0.01
ポリクオタニウム-49 0.2
フェノキシエタノール 0.4
PCA-Na 0.1
D部
精製水 合計で100となる量
塩基性青99 0.1
塩基性茶16 0.13
HC青2 0.05
HC黄2 0.03
HC赤3 0.1
ヒドロキシエチルウレア 0.5
アルギニン 0.2
炭酸水素アンモニウム 1.0
E部
実施例12の組成物 5.0
--------------------------------------
(調製方法)
あらかじめ均一に混合しておいたA部をB部に添加し約80℃に加温して溶解させた(F部)。別の容器でD部を約80℃に加温し溶解させた。F部にD部を攪拌しながら、徐々に加え均一に混合した後、急冷した(G部)。約40℃となったG部にC部、E部を加え、均一にした。
(Example 51)
hair color treatment
Component Amount (wt%)
--------------------------------------
Part A Neosolue-Aqulio (Nippon Fine Chemical) 1.0
Steartrimonium chloride (70%) 2.5
Quaternium-33 (cationic NH: Nippon Fine Chemical) 0.3
Cocamide DEA 1.0
Inulin stearate 0.5
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Beeswax 0.1
Palmitic acid dextrin 0.3
Ceresin 0.1
Capric acid PPG-3 1.0
Dicapric acid PG 1.0
Ethylhexyl ethylhexanoate 1.0
Dicaprylyl carbonate 1.5
Glycerin 4.0
Seteth-7 1.0
Isostearyl alcohol 0.3
Rice bran oil 0.5
Glyceryl stearate 0.5
Erucalactone DES (Nippon Fine Chemical) 1.5
Hydrogenated polydecene 0.1
Macadamia nut fatty acid ethyl 1.0
Dilauroylglutamate lysine Na 0.1
Behendimonium ethyl stearyl phosphate 0.1
Tocopherol 0.05
Phenoxyethanol 0.3
Part C Purified water 10.0
BG 2.0
Acylated hydrolyzed collagen 0.1
Panthenol 0.1
Hydroxyethylcellulose 0.1
Polyquaternium-64 0.1
Polyquaternium-51 0.01
Polyquaternium-49 0.2
Phenoxyethanol 0.4
PCA-Na 0.1
Part D Purified water Amount to make a total of 100 Basic blue 99 0.1
Basic tea 16 0.13
HC blue 2 0.05
HC yellow 2 0.03
HC red 3 0.1
Hydroxyethylurea 0.5
Arginine 0.2
Ammonium bicarbonate 1.0
Part E Composition of Example 12 5.0
--------------------------------------
(Preparation method)
Part A, which had been uniformly mixed in advance, was added to Part B and heated to about 80°C to dissolve it (Part F). Part D was heated to about 80° C. and dissolved in a separate container. Part D was gradually added to Part F with stirring, mixed uniformly, and then rapidly cooled (Part G). Parts C and E were added to part G, which had reached about 40°C, to make it uniform.
(実施例52)
ヘアマニキュア
成 分 配合量(重量%)
--------------------------------------
A部
エタノール 10.0
カルナウバワックス 0.01
セテス-10 1.0
エルカラクトンDES(日本精化) 2.5
PPG-3カプリリルエーテル 1.0
ネオペンタン酸イソデシル
(DUB VCI-10:日本精化) 1.0
カプリン酸PPG-3 0.5
ジカプリン酸PG 0.5
炭酸ジカプリリル 0.5
B部
紫401 0.2
黒401 0.1
橙205 0.1
赤102 0.1
クエン酸 2.0
ベンジルアルコール 8.0
エタノール 10.0
C部
精製水 合計で100となる量
(アクリロイルジメチルタウリンアンモニウム/VP)コポリマー 3.0
グリコール酸 2.0
キサンタンガム 0.2
D部
実施例12の組成物 5.0
--------------------------------------
(調製方法)
A部、C部をそれぞれ混合し、均一にした。B部に攪拌しながらC部に加え、均一に混合した後、A部を約60℃で加え、均一に混合した。約40℃に冷却し、D部を加え、均一に混合した。
(Example 52)
hair manicure
Component Amount (wt%)
--------------------------------------
Part A Ethanol 10.0
Carnauba wax 0.01
Seteth-10 1.0
Erucalactone DES (Nippon Fine Chemical) 2.5
PPG-3 caprylyl ether 1.0
Isodecyl neopentanoate (DUB VCI-10: Nippon Fine Chemical) 1.0
Capric acid PPG-3 0.5
Dicapric acid PG 0.5
Dicaprylyl carbonate 0.5
Part B Purple 401 0.2
Black 401 0.1
Orange 205 0.1
Red 102 0.1
Citric acid 2.0
Benzyl alcohol 8.0
Ethanol 10.0
Part C Purified water Amount that makes the total 100 (Acryloyldimethyltaurine ammonium/VP) copolymer 3.0
Glycolic acid 2.0
Xanthan gum 0.2
Part D Composition of Example 12 5.0
--------------------------------------
(Preparation method)
Part A and Part C were mixed and made uniform. The mixture was added to Part C while stirring to Part B and mixed uniformly. Part A was then added at about 60° C. and mixed uniformly. Cool to about 40° C., add Part D, and mix uniformly.
(実施例53)
水含有グロス
成 分 配合量(重量%)
---------------------------------
A部
オクチルドデカノール 27.0
エチルセルロース 2.5
リンゴ酸ジイソステアリル 10.0
トリエチルヘキサノイン(IOTG:日本精化) 3.0
LUSPLAN PI-DA(日本精化) 2.0
LUSPLAN DD-DHR(日本精化) 2.0
Plandool-MAS(日本精化) 0.1
Plandool-H(日本精化) 0.1
ジメチルシリル化シリカ 0.2
ステアリン酸イヌリン 0.3
PEG-60水添ヒマシ油 1.0
赤色202号 適量
黄色4号 適量
酸化チタン 適量
ステアリン酸ソルビタン、ヤシ脂肪酸スクロース混合物
(クローダ(株)製 ALACEL2121) 3.0
B部
グリセリン 7.0
Neosolue-AquaS(日本精化) 0.4
マルトース 2.0
フェノキシエタノール 0.2
実施例12の組成物 4.0
水 合計で100となる量
----------------------------------
(調製方法)
A部とB部をそれぞれ加熱溶解し、A部にB部を加え、混合した後、約40℃に冷却した。
(Example 53)
water-containing gloss
Component Amount (wt%)
---------------------------------
Part A Octyldodecanol 27.0
Ethyl cellulose 2.5
Diisostearyl malate 10.0
Triethylhexanoin (IOTG: Nippon Fine Chemical) 3.0
LUSPLAN PI-DA (Nippon Fine Chemical) 2.0
LUSPLAN DD-DHR (Nippon Fine Chemical) 2.0
Plandool-MAS (Nippon Fine Chemical) 0.1
Plandool-H (Nippon Fine Chemical) 0.1
Dimethylsilylated silica 0.2
Inulin stearate 0.3
PEG-60 hydrogenated castor oil 1.0
Red No. 202 Appropriate amount Yellow No. 4 Appropriate amount Titanium oxide Appropriate amount Sorbitan stearate, coconut fatty acid sucrose mixture (ALACEL2121 manufactured by Croda Co., Ltd.) 3.0
Part B Glycerin 7.0
Neosolue-AquaS (Nippon Fine Chemical) 0.4
maltose 2.0
Phenoxyethanol 0.2
Composition of Example 12 4.0
Water Amount that makes a total of 100----------------------------------
(Preparation method)
Part A and Part B were each heated and melted, Part B was added to Part A, mixed, and then cooled to about 40°C.
(実施例54)
水含有グロス
成 分 配合量(重量%)
---------------------------------
A部
オクチルドデカノール 27.0
エチルセルロース 2.5
水添ポリイソブテン 10.0
セバシン酸イソプロピル(日本精化) 3.0
LUSPLAN PI-DA(日本精化) 2.0
LUSPLAN SR-DP4(日本精化) 2.0
Plandool-G(日本精化) 0.1
Plandool-SUN(日本精化) 0.1
Plandool-ISS(日本精化) 0.1
YOFCO MAC(日本精化) 0.1
Plandool-LG1(日本精化) 0.1
Plandool-LG2(日本精化) 0.1
Plandool-LG3(日本精化) 0.1
Plandool-LG4(日本精化) 0.1
ジメチルシリル化シリカ 0.5
パルミチン酸デキストリン 0.1
PEG-60水添ヒマシ油 1.0
赤色202号 適量
赤色218号 適量
赤色223号 適量
橙色201号 適量
ステアリン酸ソルビタン、ヤシ脂肪酸スクロース混合物
(クローダ(株)製 ALACEL2121) 3.0
B部
グリセリン 7.0
Neosolue-AquaS(日本精化) 0.4
マルトース 2.0
フェノキシエタノール 0.2
水 合計で100となる量
D部
実施例12の組成物 1.0
---------------------------------
(調製方法)
A部とB部をそれぞれ加熱溶融し、均一にし、A部にB部を混合した。約40℃に冷却し、D部を加え、均一に混合した。
(Example 54)
water-containing gloss
Component Amount (wt%)
---------------------------------
Part A Octyldodecanol 27.0
Ethyl cellulose 2.5
Hydrogenated polyisobutene 10.0
Isopropyl sebacate (Nippon Fine Chemical) 3.0
LUSPLAN PI-DA (Nippon Fine Chemical) 2.0
LUSPLAN SR-DP4 (Nippon Fine Chemical) 2.0
Plandool-G (Nippon Fine Chemical) 0.1
Plandool-SUN (Nippon Fine Chemical) 0.1
Plandool-ISS (Nippon Fine Chemical) 0.1
YOFCO MAC (Nippon Fine Chemical) 0.1
Plandool-LG1 (Nippon Fine Chemical) 0.1
Plandool-LG2 (Nippon Fine Chemical) 0.1
Plandool-LG3 (Nippon Fine Chemical) 0.1
Plandool-LG4 (Nippon Fine Chemical) 0.1
Dimethylsilylated silica 0.5
Palmitic acid dextrin 0.1
PEG-60 hydrogenated castor oil 1.0
Red No. 202 Appropriate amount Red No. 218 Appropriate amount Red No. 223 Appropriate amount Orange No. 201 Appropriate amount Sorbitan stearate, coconut fatty acid sucrose mixture (ALACEL2121 manufactured by Croda Co., Ltd.) 3.0
Part B Glycerin 7.0
Neosolue-AquaS (Nippon Fine Chemical) 0.4
maltose 2.0
Phenoxyethanol 0.2
Water Amount D totaling 100 Composition of Example 12 1.0
---------------------------------
(Preparation method)
Part A and Part B were respectively heated and melted to make them uniform, and Part B was mixed with Part A. Cool to about 40° C., add Part D, and mix uniformly.
(実施例55)
リキッドファンデーション
成 分 配合量(重量%)
---------------------------------
A部
Plandool-G(日本精化) 5.0
ステアリン酸グリセリル(SE) 1.0
ステアリン酸PG(SE) 1.0
トコフェロール 0.1
プロピルパラベン 1.0
B部
酸化チタン・酸化鉄混合物
(東色ピグメント(株)製 FDP-W-007) 18.0
マイカ 7.0
BG 5.0
メチルパラベン 0.2
精製水 合計で100となる量
C部
セルロースガム(2%水分散液) 5.0
キサンタンガム(2%水分散液) 5.0
D部
実施例12の組成物 10.0
---------------------------------
(調製方法)
A部、B部、C部を加温混合した。A部にB部を加え、乳化させた後、約50℃まで冷却し、C部、D部を加え均一になるまで撹拌した。
(Example 55)
liquid foundation
Component Amount (weight%)
---------------------------------
Part A Plandool-G (Nippon Fine Chemical) 5.0
Glyceryl stearate (SE) 1.0
Stearic acid PG (SE) 1.0
Tocopherol 0.1
Propylparaben 1.0
Part B Titanium oxide/iron oxide mixture (manufactured by Toshiki Pigment Co., Ltd. FDP-W-007) 18.0
Mica 7.0
BG 5.0
Methylparaben 0.2
Purified water Amount to make a total of 100 Part C Cellulose gum (2% water dispersion) 5.0
Xanthan gum (2% water dispersion) 5.0
Part D Composition of Example 12 10.0
---------------------------------
(Preparation method)
Part A, Part B, and Part C were heated and mixed. After adding Part B to Part A and emulsifying it, it was cooled to about 50°C, Parts C and D were added, and the mixture was stirred until uniform.
(実施例56)
リキッドファンデーション
成 分 配合量(重量%)
---------------------------------
A部
精製水 合計で100となる量
実施例12の組成物 1.0
カルボキシビニルポリマー 0.1
水酸化カリウム 適量
DPG 5.0
防腐剤 適量
B部
ポリオキシエチレン変性ジメチルポリシロキサン 1.0
トリメチルシロキシケイ酸 3.0
フェニルメチコン 1.0
シクロメチコン 9.0
C部
亜鉛華 10.0
セリサイト 0.36
酸化チタン 8.32
酸化鉄黄 0.8
酸化鉄赤 0.36
酸化鉄黒 0.16
-----------------------------------
(調製方法)
A部を70℃に加熱撹拌後、C部を添加し分散処理した。これをあらかじめ70℃に加熱しておいてB部に添加して乳化分散した。約40℃まで冷却し、均一に混合した。
(Example 56)
liquid foundation
Component Amount (wt%)
---------------------------------
Part A Purified water Amount that makes a total of 100 Composition of Example 12 1.0
Carboxyvinyl polymer 0.1
Potassium hydroxide appropriate amount DPG 5.0
Preservative appropriate amount Part B Polyoxyethylene modified dimethyl polysiloxane 1.0
Trimethylsiloxysilicic acid 3.0
Phenylmethicone 1.0
Cyclomethicone 9.0
C part Zinc white 10.0
Sericite 0.36
Titanium oxide 8.32
Iron oxide yellow 0.8
Iron oxide red 0.36
Iron oxide black 0.16
-----------------------------------
(Preparation method)
After heating and stirring Part A to 70°C, Part C was added and dispersed. This was heated to 70° C. in advance and added to Part B to emulsify and disperse it. The mixture was cooled to about 40° C. and mixed uniformly.
(実施例57)
ファンデーション
成 分 配合量(重量%)
------------------------------------
A部
水添ポリイソブテン 5.0
シクロペンタシロキサン 4.0
ミネラルオイル 4.0
メトキシケイヒ酸エチルヘキシル 3.0
Plandool-H(日本精化) 1.0
Plandool-G(日本精化) 1.0
Plandool-MAS(日本精化) 1.0
ワセリン 1.0
フェニルトリメチコン 2.0
イソステアリン酸ソルビタン 1.5
トリベヘニン 0.5
(アクリル酸ブチル/ジメタクリル酸グリコール)クロスポリマー、
シリカ、(メタクリル酸メチル/ジメタクリル酸グリコール)
クロスポリマー混合物 2.0
窒化ホウ素 1.0
PEG/PPG-19/19ジメチコン、
シクロペンタシロキサン混合物 4.0
ジステアルジモニウムヘクトライト(20%) 2.5
ポリプロピルシルセスキオキサン、
シクロペンタシロキサン混合物 1.0
マイカ 15.0
タルク 4.0
酸化亜鉛 5.0
酸化チタン 10.0
酸化鉄 1.5
B部
水 合計で100となる量
DPG 4.0
マルチトール(75%液) 1.0
Neosolue-AquaS(日本精化) 0.4
塩化Na 1.0
BG 1.0
ヒアルロン酸(1%液) 0.1
フェノキシエタノール 0.3
実施例12の組成物 5.0
------------------------------------
(調製方法)
A部を約70℃に加温、よく攪拌し均一に分散させた。B部を約70℃に加温、均一にしたのちA部にB部を加え、約70℃で撹拌乳化し、約40℃まで冷却した。
(Example 57)
Foundation
Component Amount (wt%)
------------------------------------
Part A Hydrogenated polyisobutene 5.0
Cyclopentasiloxane 4.0
mineral oil 4.0
Ethylhexyl methoxycinnamate 3.0
Plandool-H (Nippon Fine Chemical) 1.0
Plandool-G (Nippon Fine Chemical) 1.0
Plandool-MAS (Nippon Fine Chemical) 1.0
Vaseline 1.0
Phenyltrimethicone 2.0
Sorbitan Isostearate 1.5
Tribehenin 0.5
(butyl acrylate/glycol dimethacrylate) crosspolymer,
Silica, (methyl methacrylate/glycol dimethacrylate)
Crosspolymer mixture 2.0
Boron nitride 1.0
PEG/PPG-19/19 dimethicone,
Cyclopentasiloxane mixture 4.0
Disteardimonium hectorite (20%) 2.5
polypropylsilsesquioxane,
Cyclopentasiloxane mixture 1.0
Mica 15.0
Talc 4.0
Zinc oxide 5.0
Titanium oxide 10.0
Iron oxide 1.5
Part B Water Amount that totals 100 DPG 4.0
Maltitol (75% liquid) 1.0
Neosolue-AquaS (Nippon Fine Chemical) 0.4
Na chloride 1.0
BG 1.0
Hyaluronic acid (1% liquid) 0.1
Phenoxyethanol 0.3
Composition of Example 12 5.0
------------------------------------
(Preparation method)
Part A was heated to about 70°C and stirred well to uniformly disperse the mixture. After heating Part B to about 70°C and making it uniform, Part B was added to Part A, stirred and emulsified at about 70°C, and cooled to about 40°C.
(実施例58)
下地クリーム
成 分 配合量(重量%)
---------------------------------
A部
LUSPLAN DD-DA7(日本精化) 5.0
アルガニアスピノサ核油 0.1
シクロメチコン 14.0
トリメチルシロキシケイ酸 3.0
ステアリン酸グリセリル(SE) 2.0
ステアリン酸PG(SE) 2.0
Plandool-MAS(日本精化) 0.5
ステアリン酸 0.5
パルミチン酸 0.5
メトキシケイヒ酸エチルヘキシル 0.5
トコフェロール 0.2
B部
BG 10.0
エタノール 1.0
マイカ 8.0
タルク 7.0
フェノキシエタノール 0.8
チタン酸(Li/コバルト) 0.2
精製水 合計で100となる量
C部
デキストリン(1%) 1.0
キサンタンガム(10%) 1.0
セルロースガム(10%) 1.0
製造例1のイヌリン組成物 1.5
精製水 10.0
---------------------------------
(調製方法)
A部、B部をそれぞれ別容器で加温溶解させた。A部にB部を加え、乳化させた後、C部を加え、均一に混合した。攪拌後40℃まで冷却した。
(Example 58)
base cream
Component Amount (wt%)
---------------------------------
Part A LUSPLAN DD-DA7 (Nippon Fine Chemical) 5.0
Argania Spinosa Kernel Oil 0.1
Cyclomethicone 14.0
Trimethylsiloxysilicic acid 3.0
Glyceryl stearate (SE) 2.0
Stearic acid PG (SE) 2.0
Plandool-MAS (Nippon Fine Chemical) 0.5
Stearic acid 0.5
Palmitic acid 0.5
Ethylhexyl methoxycinnamate 0.5
Tocopherol 0.2
Part B BG 10.0
Ethanol 1.0
Mica 8.0
Talc 7.0
Phenoxyethanol 0.8
Titanic acid (Li/cobalt) 0.2
Purified water Total amount of 100 Part C Dextrin (1%) 1.0
Xanthan gum (10%) 1.0
Cellulose gum (10%) 1.0
Inulin composition of Production Example 1 1.5
Purified water 10.0
---------------------------------
(Preparation method)
Part A and Part B were heated and dissolved in separate containers. After adding Part B to Part A and emulsifying it, Part C was added and mixed uniformly. After stirring, the mixture was cooled to 40°C.
(実施例59)
サンスクリーン化粧料
成 分 配合量(重量%)
----------------------------------
A部
クオタニウム-18ヘクトライト 1.0
B部
シクロメチコン 13.7
ジフェニルジメチコン 2.0
シクロペンタシロキサン 10.0
Plandool-H(日本精化) 1.0
Plandool-G(日本精化) 0.5
Plandool-MAS(日本精化) 2.0
炭酸ジカプリリル 1.0
ジメチコンコポリオール 5.5
C部
シリコーン処理微粒子酸化チタン 3.9
シリコーン処理酸化亜鉛 2.1
D部
ステアリン酸Al 0.7
水酸化Al 0.5
イソノナン酸イソノニル 2.5
ネオペンタン酸イソデシル
(DUB VCI-10:日本精化) 1.0
Neosolue-MP(日本精化) 1.0
Neosolue-DE(日本精化) 1.0
E部
トリメチルシロキシケイ酸 1.2
グリチルレチン酸ステアリル 0.02
セスキオレイン酸ソルビタン 2.0
トコフェロール 0.02
F部
塩化Na 1.0
メチルパラベン 0.15
精製水 合計で100となる量
G部
実施例12の組成物 7.0
---------------------------------
(調製方法)
A部をB部に加え,攪拌した。更にCを加えローラーミルを使用して分散させた。D部を加温融解して、A・B・C部の混合物に加え、更にE部を加えて約70℃にした。F部を加温し、AからE部の混合物に撹拌しながら徐々に乳化した。撹拌しながら冷却し40~35℃でG部を加え、均一に混合した。
(Example 59)
sunscreen cosmetics
Component Amount (wt%)
----------------------------------
Part A Quaternium-18 Hectorite 1.0
Part B Cyclomethicone 13.7
Diphenyl dimethicone 2.0
Cyclopentasiloxane 10.0
Plandool-H (Nippon Fine Chemical) 1.0
Plandool-G (Nippon Fine Chemical) 0.5
Plandool-MAS (Nippon Fine Chemical) 2.0
Dicaprylyl carbonate 1.0
Dimethicone copolyol 5.5
Part C Silicone-treated fine particle titanium oxide 3.9
Siliconized Zinc Oxide 2.1
Part D Al stearate 0.7
Al hydroxide 0.5
Isononyl isononanoate 2.5
Isodecyl neopentanoate (DUB VCI-10: Nippon Fine Chemical) 1.0
Neosolue-MP (Nippon Fine Chemical) 1.0
Neosolue-DE (Nippon Fine Chemical) 1.0
Part E Trimethylsiloxysilicic acid 1.2
Stearyl glycyrrhetinate 0.02
Sorbitan sesquioleate 2.0
Tocopherol 0.02
Part F Na chloride 1.0
Methylparaben 0.15
Purified water Quantity G parts totaling 100 Composition of Example 12 7.0
---------------------------------
(Preparation method)
Part A was added to part B and stirred. Furthermore, C was added and dispersed using a roller mill. Part D was melted by heating and added to the mixture of Parts A, B, and C, and then Part E was added to the mixture at about 70°C. Part F was heated and gradually emulsified into the mixture of Parts A to E with stirring. The mixture was cooled while stirring, and part G was added at 40 to 35° C. and mixed uniformly.
(実施例60)
サンスクリーン化粧料
成 分 配合量(重量%)
-----------------------------------
A部
Phytocompo-PP(日本精化) 1.0
BG 10.0
グリセリン 9.0
B部
オクトクリレン 4.0
サリチル酸オクチル 4.0
ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル 2.25
t-ブチルメトキシジベンゾイルメタン 1.0
セバシン酸ジエチルヘキシル
(Neosolue-EHS:日本精化) 3.0
テトラエチルヘキサン酸ペンタエリスリチル
(NS-408:日本精化) 2.0
セバシン酸イソプロピル(日本精化) 1.0
ベヘニルアルコール 2.0
セテアリルアルコール 2.0
Plandool-MAS(日本精化) 1.0
トコフェロール 0.05
C部
Neosolue-AquaS(日本精化) 1.0
メチルパラベン 適量
水 合計で100となる量
D部
カルボマー(2%) 5.0
水分散酸化チタン 5.0
製造例1のイヌリン組成物 3.5
Tremoist-TP(日本精化) 0.1
精製水 10.0
-----------------------------------
(調製方法)
A部を均一に分散した。B部、C部をそれぞれ約70℃に加温溶解した。A部にB部を徐々に添加後、C部を徐々に添加し、乳化した。攪拌しながら冷却し、45℃でD部を加え攪拌した。
(Example 60)
sunscreen cosmetics
Component Amount (wt%)
-----------------------------------
Part A Phytocompo-PP (Nippon Fine Chemical) 1.0
BG 10.0
Glycerin 9.0
Part B Octocrylene 4.0
Octyl salicylate 4.0
Diethylaminohydroxybenzoylhexylbenzoate 2.25
t-Butylmethoxydibenzoylmethane 1.0
Diethylhexyl sebacate (Neosolue-EHS: Nippon Fine Chemical) 3.0
Pentaerythrityl tetraethylhexanoate (NS-408: Nippon Fine Chemical) 2.0
Isopropyl sebacate (Nippon Fine Chemical) 1.0
Behenyl alcohol 2.0
Cetearyl alcohol 2.0
Plandool-MAS (Nippon Fine Chemical) 1.0
Tocopherol 0.05
C part Neosolue-AquaS (Nippon Fine Chemical) 1.0
Methylparaben Appropriate amount Water Amount to make a total of 100 Part D Carbomer (2%) 5.0
Water-dispersed titanium oxide 5.0
Inulin composition of Production Example 1 3.5
Tremoist-TP (Nippon Fine Chemical) 0.1
Purified water 10.0
-----------------------------------
(Preparation method)
Part A was uniformly dispersed. Part B and Part C were each dissolved by heating to about 70°C. After gradually adding Part B to Part A, Part C was gradually added and emulsified. The mixture was cooled with stirring, and part D was added at 45° C. and stirred.
(実施例61)
サンスクリーン化粧料
成 分 配合量(重量%)
---------------------------------
A部
Phytocompo-PP(日本精化) 1.0
BG 10.0
グリセリン 9.0
B部
メトキシケイヒ酸エチルヘキシル 7.0
ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル 7.0
ベヘニルアルコール 4.0
Plandool-LG1(日本精化) 0.5
Plandool-MAS(日本精化) 1.0
C部
メチルパラベン 0.15
精製水 合計で100となる量
D部
キサンタンガム 0.2
ヒアルロン酸Na 0.01
実施例12の組成物 3.0
---------------------------------
(調製方法)
A部を均一に分散した。B部、C部をそれぞれ約70℃に加温溶解した。A部にB部を徐々に添加後、C部を徐々に添加し、乳化した。攪拌しながら冷却し、45℃でD部、E部を加え、均一に混合した。
(Example 61)
sunscreen cosmetics
Component Amount (weight%)
---------------------------------
Part A Phytocompo-PP (Nippon Fine Chemical) 1.0
BG 10.0
Glycerin 9.0
Part B Ethylhexyl methoxycinnamate 7.0
Diethylaminohydroxybenzoyl hexyl benzoate 7.0
Behenyl alcohol 4.0
Plandool-LG1 (Nippon Fine Chemical) 0.5
Plandool-MAS (Nippon Fine Chemical) 1.0
Part C Methylparaben 0.15
Purified water Amount to make a total of 100 Part D Xanthan gum 0.2
Hyaluronic acid Na 0.01
Composition of Example 12 3.0
---------------------------------
(Preparation method)
Part A was uniformly dispersed. Part B and Part C were each dissolved by heating to about 70°C. After gradually adding Part B to Part A, Part C was gradually added and emulsified. The mixture was cooled while stirring, and Part D and Part E were added at 45° C. and mixed uniformly.
(実施例62)
クリーム
成 分 配合量(重量%)
-----------------------------------
A部
ミネラルオイル 7.8
ワセリン 7.0
スクワラン 0.2
ホホバ油 0.15
マイクロクリスタリンワックス 2.4
パラフィンワックス 2.0
ジステアリン酸Al 0.9
水添ポリイソブテン 2.8
ラノリンアルコール
(Ecolano AL-E:日本精化) 2.3
オクチルドデカノール 3.0
B部
硫酸Mg 0.5
安息香酸Na 0.1
濃グリセリン 3.5
実施例12の組成物 5.0
精製水 合計で100となる量
C部
ステアリン酸Mg 0.9
シクロメチコン 2.5
-----------------------------------
(調製方法)
A部、B部を加温溶解し、均一に分散した。A部にB部を徐々に添加し乳化し、分散したC部を配合し、攪拌しながら冷却した。約40℃でC部を加え、均一に混合した。
(Example 62)
cream
Component Amount (wt%)
-----------------------------------
Part A Mineral oil 7.8
Vaseline 7.0
Squalane 0.2
Jojoba oil 0.15
Microcrystalline wax 2.4
paraffin wax 2.0
Al distearate 0.9
Hydrogenated polyisobutene 2.8
Lanolin alcohol (Ecolano AL-E: Nippon Fine Chemical) 2.3
Octyldodecanol 3.0
Part B Mg sulfate 0.5
Sodium benzoate 0.1
Concentrated glycerin 3.5
Composition of Example 12 5.0
Purified water Amount that makes the total 100 Part C Mg stearate 0.9
Cyclomethicone 2.5
-----------------------------------
(Preparation method)
Part A and Part B were dissolved by heating and uniformly dispersed. Part B was gradually added to part A to emulsify it, and the dispersed part C was blended and cooled with stirring. Part C was added at about 40° C. and mixed uniformly.
(実施例63)
スキンケアオイル
成 分 配合量(重量%)
-----------------------------------
A部
オリーブ油 24.0
スクワラン 24.0
Neosolue-MCT(日本精化) 10.0
Plandool-SUN(日本精化) 2.0
トコフェロール 0.1
B部
Neosolue-AquaS(日本精化) 0.5
NaCl 0.1
メチルパラベン 0.1
フェノキシエタノール 0.4
水 合計で100となる量
実施例12の組成物 2.0
-----------------------------------
(調製方法)
A部を50℃に加温し、均一に溶解し、室温まで冷却した。B部を80℃に加温し、均一に溶解し、約40℃まで冷却した。A部とB部と混合した。
(Example 63)
skin care oil
Component Amount (weight%)
-----------------------------------
Part A Olive oil 24.0
Squalane 24.0
Neosolue-MCT (Nippon Fine Chemical) 10.0
Plandool-SUN (Nippon Fine Chemical) 2.0
Tocopherol 0.1
Part B Neosolue-AquaS (Nippon Fine Chemical) 0.5
NaCl 0.1
Methylparaben 0.1
Phenoxyethanol 0.4
Water Amounts totaling 100 Composition of Example 12 2.0
-----------------------------------
(Preparation method)
Part A was heated to 50°C to uniformly dissolve, and cooled to room temperature. Part B was heated to 80°C, uniformly dissolved, and cooled to about 40°C. Part A and Part B were mixed.
上記処方において、製品名で記載された成分の詳細は下記のとおりである。
〇LP70H:水添リゾレシチン
〇LUSPLAN DD-IS:ジイソステアリン酸ダイマージリノレイル
〇LUSPLAN PI-DA:ダイマージリノール酸ジ(イソステアリル/フィトステリル)
〇LUSPLAN DD-DHR:ダイマージリノレイル水添ロジン縮合物
〇LUSPLAN DD-DA5:ダイマージリノール酸ダイマージリノレイル
〇LUSPLAN DD-DA7:ダイマージリノール酸ダイマージリノレイル
〇LUSPLAN SR-DP4:ダイマージリノール酸ダイマージリノレイル、テトライソステアリン酸ペンタエリスリチル
〇LUSPLAN SR-DM4:ダイマージリノール酸ダイマージリノレイル、トリ(カプリル酸/カプリン酸)グリセリル
〇Neosolue-Aqulio:シクロヘキサンジカルボン酸ビスエトキシジグリコール
〇Neosolue-AquaS:エイコサン二酸/テトラデカン二酸)ポリグリセリル-10
〇Neosolue-MCT:トリ(カプリル酸/カプリン酸)グリセリル
〇Neosolue-MP:ジネオペンタン酸メチルペンタンジオール
〇Neosolue-DE:ジネオペンタン酸ジエチルペンタンジオール
〇Plandool-ISS:イソステアリン酸フィトステリル
〇Plandool-MAS:マカデミアナッツ油脂肪酸フィトステリル
〇Plandool-LG1:ラウロイルグルタミン酸ジ(フィトステリル/オクチルドデシル/ベヘニル)
〇Plandool-LG2:ラウロイルグルタミン酸ジ(フィトステリル/オクチルドデシル)
〇Plandool-LG3:ラウロイルグルタミン酸ジ(フィトステリル/オクチルドデシル/ベヘニル)
〇Plandool-LG4:ラウロイルグルタミン酸ジ(フィトステリル/オクチルドデシル/ベヘニル)
〇Plandool-DP:ビスジグリセリルポリアシルアジペート-2
〇Plandool-SUN:ヒマワリ種子油脂肪酸フィトステリル
〇Plandool-G:ダイマージリノール酸ダイマージリノレイルビス(ベヘニル/イソステアリル/フィトステリル)
〇Plandool-H:ダイマージリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)
〇Plandool-S:ダイマージリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)
〇Phytopresome MEL:糖脂質、水添レシチン、BG、精製水
〇Phytocompo-SP:水添レシチン、フィトステロールズ、BG、グリセリン〇Phytocompo-PP:水添レシチン、フィトステロールズ
〇Phytocompo-C:水添レシチン、フィトステロールズ、セラミド2、セラミド3、セラミド6II
〇Tremoist-TP:シロキクラゲ多糖体
〇VCエチル:3-O-エチルアスコルビン酸
〇YOFCO MAC:マカデミアナッツ油脂肪酸コレステリル
〇エルカラクトンDES:γ-ドコサラクトン、セバシン酸ジエチル
〇エルカラクトンMCT:γ-ドコサラクトン、トリ(カプリル酸/カプリン酸)グリセリル
In the above formulation, the details of the ingredients listed in the product name are as follows.
〇LP70H: Hydrogenated lysolecithin 〇 LUSPLAN DD-IS: Dimer dilinoleyl diisostearate 〇 LUSPLAN PI-DA: Dimer dilinoleate di(isostearyl/phytosteryl)
〇 LUSPLAN DD-DHR: Dimer dilinoleyl hydrogenated rosin condensate 〇 LUSPLAN DD-DA5: Dimer dilinoleyl dimer dilinoleic acid 〇 LUSPLAN DD-DA7: Dimer dilinoleyl dimer dilinoleic acid 〇 LUSPLAN SR-DP4: Dimer dilinoleyl dilinoleate Dimer dilinoleyl dilinoleic acid, pentaerythrityl tetraisostearate 〇Neosolue-AquaS: eicosandioic acid/tetradecanedioic acid) polyglyceryl-10
〇 Neosolue-MCT: Tri(caprylic/capric) glyceryl 〇 Neosolue-MP: Methylpentanediol dineopentanoate 〇 Neosolue-DE: Diethylpentanediol dineopentanoate 〇 Plandool-ISS: Phytosteryl isostearate 〇 Plandool-MAS: Maca demi nut oil fatty acids Phytosteryl〇Plandool-LG1: Lauroylglutamic acid di(phytosteryl/octyldodecyl/behenyl)
〇Plandool-LG2: Lauroylglutamic acid di(phytosteryl/octyldodecyl)
〇Plandool-LG3: Lauroylglutamic acid di(phytosteryl/octyldodecyl/behenyl)
〇Plandool-LG4: Lauroylglutamic acid di(phytosteryl/octyldodecyl/behenyl)
〇Plandool-DP: Bisdiglyceryl polyacyl adipate-2
〇Plandool-SUN: Sunflower seed oil fatty acid phytosteryl 〇Plandool-G: Dimer dilinoleic acid dimer dilinoleyl bis(behenyl/isostearyl/phytosteryl)
〇Plandool-H: Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl)
〇Plandool-S: Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl)
〇Phytopresome MEL: Glycolipid, hydrogenated lecithin, BG, purified water 〇Phytocompo-SP: Hydrogenated lecithin, phytosterols, BG, glycerin 〇Phytocompo-PP: Hydrogenated lecithin, phytosterols 〇Phytocompo-C: Hydrogenated lecithin, Phytosterols, Ceramide 2, Ceramide 3, Ceramide 6II
〇Tremoist-TP: White fungus polysaccharide 〇VC ethyl: 3-O-ethyl ascorbic acid 〇YOFCO MAC: Macadamia nut oil fatty acid cholesteryl 〇Erucalactone DES: γ-docosalactone, diethyl sebacate 〇Erucalactone MCT: γ-docosalactone, Caprylic/capric triglyceride
Claims (3)
全イヌリン100質量%中、重合度が5~29のイヌリンを95質量%以上含むイヌリン組成物を含有することを特徴とする皮膚洗浄剤(但し、下記(5)、(6)、(7)及び(8)の皮膚洗浄剤を除く。)。
(5)前記イヌリン組成物を含む粉末組成物を含有する皮膚洗浄剤。
(6)油性成分と前記イヌリン組成物を含む水中油型乳化組成物を含有する皮膚洗浄剤。
(7)(a)機能性油性成分の少なくとも1種を含有する油性成分、(b)ショ糖脂肪酸エステル及び/又はポリグリセリン脂肪酸エステル、並びに、(c)リン脂質を含有する皮膚洗浄剤。
(8)カロチノイド類、又は、高度不飽和脂肪酸を含有する皮膚洗浄剤。 The average degree of polymerization of all inulin is 13 to 23,
A skin cleansing agent characterized by containing an inulin composition containing 95% by mass or more of inulin with a degree of polymerization of 5 to 29 based on 100% by mass of total inulin (provided that the following (5), (6), and (7)) (Excluding skin cleansers listed in (8) and (8)).
(5) A skin cleansing agent containing a powder composition containing the inulin composition.
(6) A skin cleansing agent containing an oil-in-water emulsion composition containing an oily component and the inulin composition.
(7) A skin cleansing agent containing (a) an oily component containing at least one functional oily component, (b) a sucrose fatty acid ester and/or a polyglycerin fatty acid ester, and (c) a phospholipid.
(8) Skin cleansers containing carotenoids or highly unsaturated fatty acids.
(9)N-アシルアミノ酸ジエステルを少なくとも含む油性成分を含む水中油型乳化組成物を乾燥して得られる粉末組成物を含有する化粧料。
(10)N-アシルアミノ酸ジエステルを含む分散粒子が油相として水相中に分散された乳化物を含有する化粧料。 An inulin composition in which the average degree of polymerization of total inulin is 13 to 23 and contains 95% by mass or more of inulin with a degree of polymerization of 5 to 29 out of 100% by mass of total inulin, as well as white fungus polysaccharide, hyaluronic acid, xanthan gum, and alginic acid. , guar gum, cationized guar gum, carrageenan, gellan gum, agarose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, and cellulose nanofiber. (Excluding cosmetics in (9) and (10)).
(9) A cosmetic containing a powder composition obtained by drying an oil-in-water emulsion composition containing an oily component containing at least an N-acylamino acid diester.
(10) A cosmetic containing an emulsion in which dispersed particles containing an N-acylamino acid diester are dispersed as an oil phase in an aqueous phase.
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