JP2013525444A5 - - Google Patents
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- Publication number
- JP2013525444A5 JP2013525444A5 JP2013508174A JP2013508174A JP2013525444A5 JP 2013525444 A5 JP2013525444 A5 JP 2013525444A5 JP 2013508174 A JP2013508174 A JP 2013508174A JP 2013508174 A JP2013508174 A JP 2013508174A JP 2013525444 A5 JP2013525444 A5 JP 2013525444A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- humans
- treatment
- following compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 208000008466 Metabolic Disease Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 0 CCCCC1(CC)NC(c2ccccc2)c2cc(OC)c(CNC(CC(O)=O)CC(O)=O)cc2*(C)C1 Chemical compound CCCCC1(CC)NC(c2ccccc2)c2cc(OC)c(CNC(CC(O)=O)CC(O)=O)cc2*(C)C1 0.000 description 2
Claims (8)
- 以下の化合物。
- 以下の化合物。
- 前記化合物が結晶質である、請求項2に記載の化合物。
- 請求項1から3のいずれかに記載の化合物の薬学的に許容される塩。
- 請求項1から4のいずれかに記載の化合物又は塩を含む医薬組成物。
- 請求項1から4のいずれかに記載の化合物又は塩を含む、ヒトにおける代謝障害の治療において使用するための医薬組成物。
- 前記代謝障害が真性糖尿病(I型及びII型)又は肥満である、請求項６に記載の医薬組成物。
- ヒトにおける代謝障害の治療において使用するための薬物の製造における、請求項1から4のいずれかに記載の化合物又は塩の使用。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32821210P | 2010-04-27 | 2010-04-27 | |
| US61/328,212 | 2010-04-27 | ||
| US32922510P | 2010-04-29 | 2010-04-29 | |
| US61/329,225 | 2010-04-29 | ||
| PCT/US2011/034024 WO2011137135A1 (en) | 2010-04-27 | 2011-04-27 | Chemical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525444A JP2013525444A (ja) | 2013-06-20 |
| JP2013525444A5 true JP2013525444A5 (ja) | 2014-05-22 |
| JP5702853B2 JP5702853B2 (ja) | 2015-04-15 |
Family
ID=44861895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508174A Active JP5702853B2 (ja) | 2010-04-27 | 2011-04-27 | 化合物 |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US9040518B2 (ja) |
| EP (1) | EP2563122B1 (ja) |
| JP (1) | JP5702853B2 (ja) |
| KR (1) | KR101769079B1 (ja) |
| CN (1) | CN102858159B (ja) |
| AR (1) | AR081337A1 (ja) |
| AU (1) | AU2011245393B2 (ja) |
| BR (1) | BR112012026767B1 (ja) |
| CA (1) | CA2795543C (ja) |
| CL (1) | CL2012003009A1 (ja) |
| CO (1) | CO6612267A2 (ja) |
| CR (1) | CR20120557A (ja) |
| CY (1) | CY1118187T1 (ja) |
| DK (1) | DK2563122T3 (ja) |
| DO (1) | DOP2012000263A (ja) |
| EA (1) | EA021753B1 (ja) |
| ES (1) | ES2588743T3 (ja) |
| HK (1) | HK1175650A1 (ja) |
| HR (1) | HRP20161103T1 (ja) |
| HU (1) | HUE029480T2 (ja) |
| IL (1) | IL222365A (ja) |
| JO (1) | JO3131B1 (ja) |
| LT (1) | LT2563122T (ja) |
| MA (1) | MA34235B1 (ja) |
| ME (1) | ME02490B (ja) |
| MX (1) | MX2012012527A (ja) |
| MY (1) | MY162933A (ja) |
| NZ (1) | NZ602754A (ja) |
| PE (1) | PE20130384A1 (ja) |
| PL (1) | PL2563122T3 (ja) |
| PT (1) | PT2563122T (ja) |
| RS (1) | RS55079B1 (ja) |
| SG (1) | SG184812A1 (ja) |
| SI (1) | SI2563122T1 (ja) |
| SM (1) | SMT201600293B (ja) |
| UA (1) | UA110338C2 (ja) |
| UY (1) | UY33353A (ja) |
| WO (1) | WO2011137135A1 (ja) |
| ZA (1) | ZA201207858B (ja) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3400944B1 (en) | 2010-11-08 | 2020-07-15 | Albireo AB | Ibat inhibitors for the treatment of liver diseases |
| BR112014004544A2 (pt) | 2011-08-31 | 2017-04-04 | Mallinckrodt Llc | modificação com peg de nanopartículas com h-fosfonatos |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| RU2015144632A (ru) | 2013-05-02 | 2017-06-07 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Терапевтические пептиды |
| JP6751020B2 (ja) | 2014-06-25 | 2020-09-02 | Ｅａファーマ株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
| CA2956833C (en) | 2014-08-05 | 2022-08-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Synthesis of benzothiazepines |
| KR101674806B1 (ko) * | 2014-10-20 | 2016-11-10 | 씨제이헬스케어 주식회사 | 신규한 아미노알킬벤조티아제핀 유도체 및 이의 용도 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| ES2903523T3 (es) | 2015-02-02 | 2022-04-04 | Valo Health Inc | Acidos 3-aril-4-amido-biciclico [4.5.0]hidroxámicos como inhibidores de HDAC |
| WO2016126726A1 (en) | 2015-02-02 | 2016-08-11 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| WO2017218950A1 (en) | 2016-06-17 | 2017-12-21 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| EP3475266B1 (en) | 2016-06-27 | 2023-09-06 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Synthetic methods |
| CA3071285A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | Cholestyramine granules, oral cholestyramine formulations and use thereof |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3100113A1 (en) | 2018-06-05 | 2019-12-12 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| MX2020013774A (es) | 2018-06-20 | 2021-03-02 | Albireo Ab | Modificaciones de cristales de odevixibat. |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CN118834175A (zh) | 2019-02-06 | 2024-10-25 | 阿尔比里奥公司 | 苯并硫氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途 |
| HUE060905T2 (hu) | 2019-02-06 | 2023-04-28 | Albireo Ab | Benzotiadiazepin vegyületek és azok alkalmazása epesav modulátorként |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| US20220160726A1 (en) * | 2019-02-12 | 2022-05-26 | Mirum Pharmaceuticals, Inc. | Methods for treating cholestasis |
| TW202134221A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻二氮呯化合物及其作為膽酸調節劑之用途 |
| AR120679A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores ácido biliar |
| AR120676A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
| JP2023504647A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| TW202134218A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其作為膽酸調節劑之用途 |
| AR120683A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
| CA3158181A1 (en) * | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| CN114761018A (zh) | 2019-12-04 | 2022-07-15 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| IL293379A (en) | 2019-12-04 | 2022-07-01 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| EP4188541A1 (en) | 2020-08-03 | 2023-06-07 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP2023548788A (ja) | 2020-10-20 | 2023-11-21 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッド | 胆汁うっ滞性そう痒症を治療する方法 |
| CA3196488A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| WO2022117778A1 (en) | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| EP4267558A1 (en) | 2020-12-23 | 2023-11-01 | GlaxoSmithKline Intellectual Property (No.2) Limited | Forms of linerixibat |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| AU2023255249A1 (en) | 2022-04-22 | 2024-10-17 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
| US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
| US20240067617A1 (en) | 2022-07-05 | 2024-02-29 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2024121434A1 (en) | 2022-12-09 | 2024-06-13 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2370015A (en) | 1933-07-24 | 1945-02-20 | Merck & Co Inc | Derivatives of tertiary amino aliphatic acids |
| GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| ZA956647B (en) * | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
| US6268392B1 (en) * | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US20020183307A1 (en) | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
| WO2002053548A1 (en) | 2000-12-27 | 2002-07-11 | Banyu Pharmaceutical Co.,Ltd. | Benzothiazepine derivatives |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US20040077625A1 (en) * | 2001-07-25 | 2004-04-22 | Tremont Samuel J. | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| BR0306643A (pt) * | 2002-01-17 | 2004-10-19 | Pharmacia Corp | Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical |
| AU2004230670B2 (en) | 2003-01-09 | 2010-11-25 | Genentech, Inc. | Purification of polypeptides |
| GB0304194D0 (en) * | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| CN101048407A (zh) | 2004-09-03 | 2007-10-03 | 普莱希科公司 | 双环杂芳基pde4b抑制剂 |
| JP2012509891A (ja) * | 2008-11-26 | 2012-04-26 | サティオゲン ファーマシューティカルズ，インク． | 肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤 |
-
2011
- 2011-04-25 JO JOP/2011/0139A patent/JO3131B1/ar active
- 2011-04-26 AR ARP110101432A patent/AR081337A1/es active IP Right Grant
- 2011-04-26 UY UY0001033353A patent/UY33353A/es not_active Application Discontinuation
- 2011-04-27 JP JP2013508174A patent/JP5702853B2/ja active Active
- 2011-04-27 PL PL11775513.2T patent/PL2563122T3/pl unknown
- 2011-04-27 CN CN201180021342.6A patent/CN102858159B/zh active Active
- 2011-04-27 KR KR1020127030621A patent/KR101769079B1/ko active IP Right Grant
- 2011-04-27 SI SI201130920A patent/SI2563122T1/sl unknown
- 2011-04-27 US US13/640,166 patent/US9040518B2/en active Active
- 2011-04-27 ES ES11775513.2T patent/ES2588743T3/es active Active
- 2011-04-27 UA UAA201211711A patent/UA110338C2/ru unknown
- 2011-04-27 MX MX2012012527A patent/MX2012012527A/es active IP Right Grant
- 2011-04-27 NZ NZ602754A patent/NZ602754A/en unknown
- 2011-04-27 WO PCT/US2011/034024 patent/WO2011137135A1/en active Application Filing
- 2011-04-27 DK DK11775513.2T patent/DK2563122T3/en active
- 2011-04-27 RS RS20160709A patent/RS55079B1/sr unknown
- 2011-04-27 MA MA35373A patent/MA34235B1/fr unknown
- 2011-04-27 PE PE2012002082A patent/PE20130384A1/es active IP Right Grant
- 2011-04-27 EP EP11775513.2A patent/EP2563122B1/en active Active
- 2011-04-27 MY MYPI2012004753A patent/MY162933A/en unknown
- 2011-04-27 EA EA201290909A patent/EA021753B1/ru not_active IP Right Cessation
- 2011-04-27 AU AU2011245393A patent/AU2011245393B2/en active Active
- 2011-04-27 CA CA2795543A patent/CA2795543C/en active Active
- 2011-04-27 LT LTEP11775513.2T patent/LT2563122T/lt unknown
- 2011-04-27 SG SG2012074860A patent/SG184812A1/en unknown
- 2011-04-27 BR BR112012026767A patent/BR112012026767B1/pt active IP Right Grant
- 2011-04-27 ME MEP-2016-160A patent/ME02490B/me unknown
- 2011-04-27 PT PT117755132T patent/PT2563122T/pt unknown
- 2011-04-27 HU HUE11775513A patent/HUE029480T2/en unknown
-
2012
- 2012-09-28 CO CO12170751A patent/CO6612267A2/es active IP Right Grant
- 2012-10-04 DO DO2012000263A patent/DOP2012000263A/es unknown
- 2012-10-11 IL IL222365A patent/IL222365A/en active IP Right Grant
- 2012-10-18 ZA ZA2012/07858A patent/ZA201207858B/en unknown
- 2012-10-26 CL CL2012003009A patent/CL2012003009A1/es unknown
- 2012-11-01 CR CR20120557A patent/CR20120557A/es unknown
-
2013
- 2013-03-07 HK HK13102840.3A patent/HK1175650A1/zh unknown
-
2016
- 2016-08-24 CY CY20161100830T patent/CY1118187T1/el unknown
- 2016-08-29 HR HRP20161103TT patent/HRP20161103T1/hr unknown
- 2016-08-29 SM SM201600293T patent/SMT201600293B/it unknown
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