JP2012239666A - Device and program for diagnosis of autonomic nervous function - Google Patents

Abstract

PROBLEM TO BE SOLVED: To determine which action α or β is stronger in the sympathetic nerve activities.SOLUTION: An autonomic nerve activity degree calculator 24 calculates the sympathetic nerve activity degree indications (LF/HF) based on electrocardiographic data measured by an electrocardiogram monitor 14. A heart rate calculator 25 calculates the heart rate of a diagnosed person based on electrocardiographic data measured by the monitor 14. A controller 18 instructs the diagnosed person to receive load tests including a stand-up test, etc. and controls a display device 22 so as to two-dimensionally display the relationship between the differences of sympathetic nerve activity degree indications (LF/HF) calculated by the calculator 24 and of the heart rate indications (HR) calculated by the calculator 25 before and after the execution of the load tests.

Description

  The present invention relates to an autonomic nerve function diagnostic apparatus and program for diagnosing an autonomic nerve function.

  Autonomic nerves include sympathetic nerves that predominate when the human body is activated and parasympathetic nerves that predominate when the human body is sedated. In a normal human body, various functions of the human body operate normally by appropriately switching between the sympathetic nerve and the parasympathetic nerve.

  When trying to make this sympathetic nerve dominant, a neurotransmitter such as adrenaline or noradrenaline is released into the body, and this noradrenaline is taken into a sympathetic receptor to enhance the state of the sympathetic nerve.

  And it is known that there are two types of receptors, α receptor and β receptor, in this sympathetic nerve receptor. It is also known that when α receptors are stimulated, α actions such as contraction of peripheral blood vessels occur, and when β receptors are stimulated, β actions such as heart rate increase and bronchodilation occur. .

  Based on these sympathetic nerve functions, antihypertensives administered to hypertensive patients include alpha blockers that inhibit the uptake of neurotransmitters into alpha receptors and neurotransmitters into beta receptors. Beta blockers that inhibit uptake may be used. For patients with orthostatic hypotension, α receptor stimulants that stimulate α receptors and β receptor stimulants that stimulate β receptors may be used.

  However, there are patients whose α receptors are likely to react (i.e., subject to stimulation) depending on individual differences, that is, patients who have a strong α action, and patients whose β receptors tend to react, that is, have a strong β action. Therefore, during various treatments and medications, it is desirable for each patient to grasp whether the α action or the β action is strong in the sympathetic nerve function.

  Conventionally, various methods have been proposed as methods for objectively diagnosing autonomic nervous function (see, for example, Patent Documents 1 to 3). However, the diagnostic methods disclosed in these conventional techniques can determine whether or not the autonomic nervous function is normal, but determine whether the subject has a strong α action or a strong β action. I couldn't.

JP 2010-35896 A Japanese Patent No. 4327243 Japanese Patent No. 4516623

  The above-described prior art has a problem in that it is impossible to diagnose whether the α action or the β action is stronger among the actions caused by the sympathetic nerve activity.

  An object of the present invention is to provide an autonomic nervous function diagnostic apparatus and program capable of easily determining whether an α action is stronger or a β action is stronger among actions caused by sympathetic nerve activity.

[Autonomic nerve function diagnosis device]
In order to achieve the above object, an autonomic nervous function diagnostic apparatus according to the present invention includes an electrocardiogram measuring means for measuring an electrocardiogram of a subject,
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
Based on the electrocardiogram data measured by the electrocardiogram measurement means, heart rate calculation means for calculating the heart rate of the diagnosis subject;
Display means for displaying biological information;
An instruction means for instructing a load test to the person to be diagnosed;
The two-dimensional display of the relationship between the difference in the sympathetic nerve activity index before and after the load test calculated by the autonomic nerve activity calculating means and the difference in the heart rate before and after the load test calculated by the heart rate calculating means. Control means for controlling the display means.

  In the present invention, a sympathetic nerve activity index and a heart rate are calculated based on electrocardiographic data measured before and after the stress test measured from the subject, and the difference between the sympathetic nerve activity index and the heart rate before and after the stress test is calculated. Two-dimensional display. The value obtained by dividing the difference in sympathetic nerve activity index before and after the stress test by the difference in heart rate before and after the stress test indicates the strength of α action, and the difference in heart rate before and after the stress test indicates the strength of β action. Indicates. Therefore, according to the present invention, it is possible to easily determine whether the α action or the β action is stronger among the actions caused by the sympathetic nerve activity.

Another autonomic nervous function diagnostic apparatus of the present invention is a receiving means for receiving the electrocardiographic data of the diagnosis subject measured by the electrocardiographic measuring means,
Autonomic nerve activity degree calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data received by the receiving means;
Based on the electrocardiogram data received by the receiving means, heart rate calculating means for calculating the heart rate of the diagnosed person;
Display means for displaying biological information;
An instruction means for instructing a load test to the person to be diagnosed;
The two-dimensional display of the relationship between the difference in the sympathetic nerve activity index before and after the load test calculated by the autonomic nerve activity calculating means and the difference in the heart rate before and after the load test calculated by the heart rate calculating means. Control means for controlling the display means.

  Further, in the autonomic nerve function diagnostic apparatus of the present invention, the control unit is configured such that the difference between the sympathetic nerve activity index before and after the load test calculated by the autonomic nerve activity calculating unit and the load calculated by the heart rate calculating unit. From the relationship with the difference in heart rate before and after the test, it is determined whether the α action is strong or the β action is strong in the sympathetic nerve function of the diagnosed person, and the determination result is controlled to be displayed on the display means. Also good.

  Further, in the autonomic nervous function diagnostic apparatus of the present invention, the control means is an index of the strength of α action obtained by dividing the difference in the sympathetic nerve activity index before and after the stress test by the difference in heart rate before and after the stress test. The difference in heart rate before and after the load test may be used as an indicator of the strength of the β action to determine whether the α action or the β action is strong in the sympathetic nerve function of the subject.

[program]
The program of the present invention includes a step of measuring the electrocardiogram of the person to be diagnosed by means of electrocardiogram measurement,
Based on the electrocardiographic data measured by the electrocardiogram measuring means, calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity;
Calculating the heart rate of the subject based on electrocardiographic data measured by the electrocardiogram measurement means;
Instructing the subject to perform a load test;
Measuring the electrocardiogram of the diagnosed person after the load test by means of electrocardiogram measurement means;
Calculating a sympathetic nerve activity index indicating a degree of sympathetic nerve activity based on electrocardiogram data after a stress test measured by the electrocardiograph measurement means;
Calculating the heart rate of the person to be diagnosed based on the electrocardiogram data after the load test measured by the electrocardiograph means;
A computer is caused to execute a step for two-dimensionally displaying the relationship between the calculated difference in sympathetic nerve activity index before and after the stress test and the calculated difference in heart rate before and after the stress test.

Another program of the present invention is a step of accepting electrocardiographic data of a diagnosis subject measured by an electrocardiogram measurement means;
Calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the received electrocardiogram data;
Calculating a heart rate of the diagnosed person based on the received electrocardiogram data;
Instructing the subject to perform a load test;
Receiving the electrocardiogram of the diagnosed person after the load test measured by the electrocardiogram measurement means;
Calculating a sympathetic nerve activity index indicating a degree of sympathetic nerve activity based on the electrocardiogram data after the accepted load test;
Calculating the heart rate of the diagnosed person based on the electrocardiogram data after the accepted load test;
A computer is caused to execute a step for two-dimensionally displaying the relationship between the calculated difference in sympathetic nerve activity index before and after the stress test and the calculated difference in heart rate before and after the stress test.

  In addition, the program of the present invention has an α action in the sympathetic nerve function of the diagnosis subject from the relationship between the difference in the sympathetic nerve activity index before and after the calculated stress test and the difference in the heart rate before and after the calculated load test. It may be determined whether the β action is strong or the β action is strong, and the computer further executes a step of displaying the determination result.

  As described above, according to the present invention, it is possible to obtain an effect that it is possible to easily determine whether the α action or the β action is stronger among the actions caused by the sympathetic nerve activity.

It is a block diagram which shows the structure of the autonomic-nerve function evaluation apparatus of one Embodiment of this invention. It is a flowchart which shows operation | movement of the autonomic-nervous function evaluation apparatus of one Embodiment of this invention. It is a flowchart for demonstrating the LF * HF calculation method in the autonomic-nervous function evaluation apparatus of one Embodiment of this invention. It is a figure which shows the heart rate fluctuation | variation measuring method in the case of LF * HF calculation. It is a figure which shows an example which spectrum-analyzed in the case of LF * HF calculation. It is a figure for demonstrating the display content displayed on the display apparatus 22 in FIG. It is a figure which shows only the determination display area | region of (beta) effect | action in the two-dimensional display shown in FIG. It is a figure which shows only the determination display area | region of (alpha) effect | action in the two-dimensional display shown in FIG. It is a figure which shows an example of the value of the heart rate HR and the sympathetic nerve activity index LF / HF before and after the standing test. It is a figure which shows the display result at the time of showing the measurement result shown in FIG. It is a figure which shows an example of the display result based on an actual measurement result. It is a figure which shows the other example of the display result based on an actual measurement result. It is a figure which shows the other example of the display result based on an actual measurement result. It is a figure which shows the other example of the display result based on an actual measurement result.

  Next, embodiments of the present invention will be described in detail with reference to the drawings. FIG. 1 is a block diagram showing a configuration of an autonomic nervous function diagnostic apparatus according to an embodiment of the present invention.

  As shown in FIG. 1, the autonomic nervous function diagnostic apparatus of the present embodiment displays an electrocardiogram monitor 14 for acquiring electrocardiographic data of a measurement subject, a control device 18, a storage device 20, and biological information. Display device 22, autonomic nerve activity calculation unit 24, and heart rate calculation unit 25.

  The electrocardiogram monitor 14 wears a minus electrode, for example, at the throat of the subject, a plus electrode on the left flank, and a body ground on the right flank, obtains heart movement as an electrical signal and records it as electrocardiographic data.

  The autonomic nerve activity calculation unit 24 calculates a sympathetic nerve activity index (LF / HF) indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram monitor 14. A specific method for calculating LF / HF will be described later.

  The heart rate calculator 25 calculates the heart rate of the diagnosis subject based on the electrocardiogram data measured by the electrocardiogram monitor 14. Specifically, the heart rate calculation 25 calculates an average value of the heart rate for 1 minute from the electrocardiogram data.

  The control device 18 is composed of, for example, a computer, processes the sympathetic nerve activity index (LF / HF) obtained by the autonomic nerve activity calculation unit 24 and the heart rate calculated by the heart rate calculation unit 25, and performs this processing. Information is stored in the storage device 20 or displayed on the display device 22.

  The control device 18 also functions as an instruction means for instructing a subject to perform a load test such as a standing test. Then, the control device 18 compares the difference between the sympathetic nerve activity index (LF / HF) calculated by the autonomic nerve activity calculation unit 24 before and after the load test (sympathetic nerve activity index change amount ΔLF / HF), and the heart rate. The display device 22 is controlled so that the relationship between the difference (heart rate change amount ΔHR) before and after the load test of the heart rate (HR) calculated by the calculation unit 25 is two-dimensionally displayed.

  Here, the difference between the sympathetic nerve activity index (LF / HF) before and after the stress test is based on the value of the sympathetic nerve activity index (LF / HF) after the stress test and the sympathetic nerve activity index (before the stress test). The value of (LF / HF) is subtracted. Similarly, the difference between the heart rate (HR) before and after the load test is obtained by subtracting the value of the heart rate (HR) before the load test from the value of the heart rate (HR) after the load test.

  Next, the operation of the autonomic nervous function diagnosis apparatus of this embodiment will be described in detail with reference to the flowchart of FIG.

  First, as an initial setting, before the diagnosis is started, information on the person to be diagnosed such as the name, age, ID number, and sex of the person to be diagnosed is input to the control device 18 (S201). In this state, the person to be diagnosed is in a resting state such as a sitting position (or a supine position).

  When the diagnosis is started, the electrocardiogram data of the diagnosis subject is measured by the electrocardiogram monitor 14 (step S202). Then, the autonomic nerve activity calculation unit 24 performs LF / HF calculation to calculate a sympathetic nerve activity index (LF / HF) indicating the activity level of the sympathetic nerve (step S203). Further, the heart rate calculation unit 25 calculates the heart rate of the diagnosis subject (step S204). The sympathetic nerve activity index (LF / HF) calculated by the autonomic nerve activity calculating unit 24 and the heart rate data calculated by the heart rate calculating unit 25 are stored in the storage device 20 by the control device 18. (Step S205).

  Next, the control device 18 instructs the person to be diagnosed to stand up via the display device 22 or the like (step S206). In the present embodiment, the load test is described as a standing test that stands from a sitting (or supine) state. However, if a moderate load can be applied to the subject, It may be an exercise load such as a red mill inspection method or another load test.

  Then, after giving a standing instruction to the diagnosis subject and waiting for a predetermined time to elapse (step S207), the electrocardiogram data of the diagnosis subject is again measured by the electrocardiogram monitor 14 (step S208). . And the autonomic nerve activity calculation part 24 performs LF / HF calculation, and calculates again the sympathetic nerve activity index (LF / HF) after a load test (step S209). The heart rate calculation unit 25 calculates again the heart rate of the diagnosed person after the load test (step S210).

  Then, the control device 18 reads the sympathetic nerve activity index (LF / HF) and heart rate before the load test stored in the storage device 20, and the sympathetic nerve activity index (LF / HF) after the load test and Calculate the difference from the heart rate. Then, the control device 18 displays the calculated sympathetic nerve activity index difference (ΔLF / HF) and heart rate difference (ΔHR) two-dimensionally on the display device 22. A specific example of this display content will be described later.

  Next, details of the LF / HF calculation method shown in steps S203 and S209 of FIG. 2 are shown in FIGS.

  First, in step S <b> 301, the autonomic nerve activity calculation unit 24 calculates heartbeat variability from electrocardiographic data input from the electrocardiogram monitor 14. The heart rate variability was calculated as shown in FIGS. 4A and B by measuring the RR interval by taking the interval between the R wave and the next R wave, and then measuring as shown in FIGS. 4C and D. The R-R interval data is plotted at the time position of the rear R-wave, and after interpolation, data is resampled at equal intervals (dotted line in FIG. 4C). In the next step S302, spectrum analysis (frequency conversion) is performed on the data obtained in step S301. An example of the spectrum analysis in step S302 is shown in FIG. In the next step S303, a low frequency component LF is obtained. Here, the low frequency component LF is an integral value of the power spectrum component of 0.04 to 0.15 Hz. In the next step S304, a high frequency component HF is obtained. Here, the high frequency component HF is an integral value of the power spectrum component of 0.15 to 0.40 Hz. In step S305, the ratio between the LF obtained in step S303 and the HF obtained in step S304 is calculated as LF / HF.

  In this way, the autonomic nerve activity calculation unit 24 calculates the sympathetic nerve activity index (LF / HF) from the electrocardiogram data measured by the electrocardiogram monitor 14. In addition, the heart rate calculation unit 25 calculates the number of heart beats per minute as the heart rate HR from the average value of the measured RR intervals.

Next, a display example displayed on the display device 22 will be described with reference to FIG.
As shown in FIG. 6, in this display example, the vertical axis is a sympathetic activity index change amount ΔLF / HF, and the horizontal axis is a heart rate change amount ΔHR.

  In this two-dimensional display, the two-dimensional plane is divided into nine areas (areas) by setting two threshold values for each value. Specifically, in the display example shown in FIG. 6, 0.5 and 5.0 are set as the threshold values of ΔLF / HF, and 5 and 10 are set as the threshold values of ΔHR.

  In the display example shown in FIG. 6, the value of the change amount ΔLF / HF of the sympathetic nerve activity index on the vertical axis is not provided with a scale at equal intervals. This is because an important range is highlighted and displayed at the time of determination.

  Here, in the present embodiment, the value (ΔLF / HF) / ΔHR obtained by dividing the difference ΔLF / HF in the sympathetic nerve activity index before and after the stress test by the difference in heart rate ΔHR before and after the stress test is the strength of α action. Whether the α action is strong or the β action is strong in the sympathetic nerve function of the diagnosed person is determined using the difference ΔHR in the heart rate before and after the stress test as the index of the strength of the β action.

  In this embodiment, with respect to (ΔLF / HF) / ΔHR, the α action is weak at 0.05 or less, and the α action is normal if it falls within the range of 0.05 to 1.0. In the case of 0 or more, the description will be made on the assumption that the α action is strong. Further, regarding ΔHR, it is assumed that the β action is weak when it is 5 or less, the β action is normal if it falls within the range of 5 to 10, and the β action is strong when it is 10 or more.

  In the display example shown in FIG. 6, since the vertical axis is the amount of change ΔLF / HF of the sympathetic nerve activity index, the display area for determining the strength of α action is ΔLF / HF = ΔHR × 1. 0.0, ΔLF / HF = ΔHR × 0.05, and a line represented by two equations is shown as a boundary. As described above, in the display example shown in FIG. 6, since the change amount ΔLF / HF of the sympathetic nerve activity index on the vertical axis is not equal, the line represented by these two equations is a straight line. Instead, it is a polygonal line whose slope changes at the point where the interval changes.

  In FIG. 6, the ranges of 5 ≦ ΔHR ≦ 10 and ΔHR × 0.05 ≦ ΔLF / HF ≦ ΔHR × 1.0 are shown as normal ranges for both α action and β action.

  In the display example shown in FIG. 6, the α action determination display area and the β action determination display area overlap in the two-dimensional display. Therefore, only the β action determination display area is shown in FIG. Only the determination display area is shown in FIG.

  As shown in FIG. 7, in the β action determination display area, an area where ΔHR is 10 or more is displayed as an area determined to have a strong β action, and an area where ΔHR is 5 or less is determined to have a weak β action. It is displayed as an area.

  As shown in FIG. 8, in the α action determination display area, an area of ΔHR × 1.0 ≦ ΔLF / HF is displayed as an area determined to have a strong α action, and ΔLF / HF ≦ ΔHR × 0. An area 05 is displayed as an area determined to have a weak α action.

  Next, FIG. 9 shows an example of the values of the heart rate HR and the sympathetic nerve activity index LF / HF before and after the standing test, which are measured by the autonomic nervous function diagnosis apparatus of the present embodiment.

  For example, as shown in FIG. 9, the sympathetic nerve activity index (LF / HF) at rest (sitting position) is 1.5, the heart rate HR is 60 (beats / minute), and the standing position after standing is Assume that the sympathetic nerve activity index (LF / HF) is 4.5 and the heart rate HR is 68 (beats / minute).

  Then, the control device 18 sets the difference in sympathetic nerve activity index before and after the stress test (ΔLF / HF) to 3.0 (4.5-1.5), and the difference in heart rate before and after the stress test (ΔHR) to 8. Calculated as (68-60). Then, the control device 18 calculates (ΔLF / HF) /ΔHR=3.0/8=0.375.

Next, based on the measurement data example shown in FIG. 9, an example of the display on the display device 22 in the autonomic nervous function diagnostic apparatus of the present embodiment is shown in FIG. 10. In the display example shown in FIG. 10, the measured values are indicated by black circles.
In the example shown in FIG. 10, the measured values are within the range of normal values for both (ΔLF / HF) / ΔHR and ΔHR. Therefore, by referring to this display content, it is possible to determine that the strengths of the functions of the α action and the β action in the sympathetic nerve function of the diagnosis subject are normal and the strengths thereof are similar.

  Next, FIGS. 11 to 14 show display examples based on measurement results obtained by measuring an actual diagnosis subject.

  FIG. 11 is a display example showing the measurement results of the subject taking the β-blocker. From this display result, it can be determined that the α action is strong and the β action is weak.

  FIG. 12 is a display example showing the measurement result of the intermittently diagnosed person who does not experience the dizziness symptom in the diagnosed person who often causes standing dizziness. From this display result, the α action is weak. , Β action can be determined to be normal. Since ΔLF / HF is a negative value, ΔLF / HF = 0 is displayed here.

  FIG. 13 is a display example showing the measurement result of the person with Parkinson's disease diagnosis, and it can be determined from this display result that both the α action and the β action are weak.

  Furthermore, FIG. 14 is a display example showing measurement results of a person with orthostatic hypotension. From this display result, it can be determined that the α action is weak and the β action is strong.

  Thus, according to the rhythmic function diagnostic apparatus of this embodiment, the measurement result of the diagnosis subject is a two-dimensional display of the difference in the sympathetic nerve activity index before and after the stress test and the difference in heart rate before and after the stress test. Shown above. On this two-dimensional display, since a determination area for determining the strength of the α action and a determination area for determining the strength of the β action are provided, the measurement result is displayed at which position. It is possible to easily determine whether the α action or the β action is stronger among the actions caused by the sympathetic nerve activity.

  And, for example, when a doctor administers an antihypertensive agent to a hypertensive patient, the autonomic nerve function diagnosis apparatus of this embodiment is used to grasp whether the α action or the β action is strong in the sympathetic nerve function of this patient. Thus, it is possible to use it as a reference when determining whether to select an alpha blocker or a beta blocker as the antihypertensive agent to be administered.

[Modification]
In the above embodiment, the electrocardiogram monitor 14 is provided, and the sympathetic nerve activity index (LF / HF) and the heart rate HR are calculated based on the electrocardiogram data measured by the electrocardiogram monitor 14. The present invention is not limited to such a configuration. Without providing the electrocardiogram monitor 14, a receiving means for receiving external electrocardiogram data is provided, and a sympathetic nerve activity index (LF / HF) and a heart rate HR are calculated based on the electrocardiographic data received by the receiving means. It can also be set as such. By adopting such a configuration, the autonomic nervous function diagnosis apparatus does not need to be provided with an electrocardiogram measurement means such as the electrocardiogram monitor 14.

  Further, in the above-described embodiment, the control device 18 is described as only displaying two-dimensional values before and after the standing test on the display device 22, but the present invention is not limited to such a case. Absent. The control device 18 determines the relationship between the difference in the sympathetic nerve activity index before and after the load test calculated by the autonomic nerve activity calculation unit 24 and the difference in the heart rate before and after the load test calculated by the heart rate calculation unit 25. Alternatively, it may be determined whether the α action is strong or the β action is strong in the sympathetic nerve function of the diagnosis subject, and the determination result is displayed on the display device 22.

  In this case, the control device 18 uses the value obtained by dividing the difference in the sympathetic nerve activity index before and after the stress test by the difference in heart rate before and after the stress test as an index of the strength of α action, and the heart rate before and after the stress test. Using the difference in number as an indicator of the strength of β action, it is determined whether the α action or β action is strong in the sympathetic nerve function of the subject.

14 ECG monitor 18 Control device 20 Storage device 22 Display device 24 Autonomic nerve activity calculation unit 25 Heart rate calculation unit S201 to S211 Steps S301 to S305 Steps

Claims (7)

An electrocardiogram measuring means for measuring the electrocardiogram of the subject;
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
Based on the electrocardiogram data measured by the electrocardiogram measurement means, heart rate calculation means for calculating the heart rate of the diagnosis subject;
Display means for displaying biological information;
An instruction means for instructing a load test to the person to be diagnosed;
The two-dimensional display of the relationship between the difference in the sympathetic nerve activity index before and after the load test calculated by the autonomic nerve activity calculating means and the difference in the heart rate before and after the load test calculated by the heart rate calculating means. Control means for controlling the display means;
An autonomic nervous function diagnostic apparatus having Accepting means for accepting electrocardiographic data of the diagnosed person measured by the electrocardiographic measuring means;
Autonomic nerve activity degree calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data received by the receiving means;
Based on the electrocardiogram data received by the receiving means, heart rate calculating means for calculating the heart rate of the diagnosed person;
Display means for displaying biological information;
An instruction means for instructing a load test to the person to be diagnosed;
The two-dimensional display of the relationship between the difference in the sympathetic nerve activity index before and after the load test calculated by the autonomic nerve activity calculating means and the difference in the heart rate before and after the load test calculated by the heart rate calculating means. Control means for controlling the display means;
An autonomic nervous function diagnostic apparatus having   The control means, from the relationship between the difference in sympathetic nerve activity index before and after the load test calculated by the autonomic nerve activity calculation means and the difference in heart rate before and after the load test calculated by the heart rate calculation means, The autonomic nerve function diagnosis apparatus according to claim 1 or 2, wherein it is determined whether the α action is strong or the β action is strong in the sympathetic nerve function of the person to be diagnosed, and the determination result is displayed on the display means.   The control means uses a value obtained by dividing the difference in the sympathetic nerve activity index before and after the stress test by the difference in heart rate before and after the stress test as an index of the strength of α action, and the difference in heart rate before and after the stress test as β 4. The autonomic nervous function diagnostic apparatus according to claim 3, wherein whether or not the α action is strong or the β action is strong in the sympathetic nerve function of the diagnosis subject is determined as an index of the strength of action. Measuring a patient's electrocardiogram by means of electrocardiography means;
Based on the electrocardiographic data measured by the electrocardiogram measuring means, calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity;
Calculating the heart rate of the subject based on electrocardiographic data measured by the electrocardiogram measurement means;
Instructing the subject to perform a load test;
Measuring the electrocardiogram of the diagnosed person after the load test by means of electrocardiogram measurement means;
Calculating a sympathetic nerve activity index indicating a degree of sympathetic nerve activity based on electrocardiogram data after a stress test measured by the electrocardiograph measurement means;
Calculating the heart rate of the person to be diagnosed based on the electrocardiogram data after the load test measured by the electrocardiograph means;
A program for causing a computer to execute a step for two-dimensionally displaying a relationship between a calculated difference in sympathetic nerve activity index before and after a load test and a calculated difference in heart rate before and after the load test. Receiving the electrocardiographic data of the diagnosis subject measured by the electrocardiogram measurement means;
Calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the received electrocardiogram data;
Calculating a heart rate of the diagnosed person based on the received electrocardiogram data;
Instructing the subject to perform a load test;
Receiving the electrocardiogram of the diagnosed person after the load test measured by the electrocardiogram measurement means;
Calculating a sympathetic nerve activity index indicating a degree of sympathetic nerve activity based on the electrocardiogram data after the accepted load test;
Calculating the heart rate of the diagnosed person based on the electrocardiogram data after the accepted load test;
A program for causing a computer to execute a step for two-dimensionally displaying a relationship between a calculated difference in sympathetic nerve activity index before and after a load test and a calculated difference in heart rate before and after the load test.   Based on the relationship between the calculated sympathetic nerve activity index difference before and after the stress test and the calculated heart rate difference before and after the stress test, it is determined whether the α action or β action is strong in the sympathetic nerve function of the subject. The program according to claim 5 or 6, further causing the computer to execute a step of determining and displaying the determination result.

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