JP2012200275A - Blood purification system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To reduce the cost of blood purification treatment by reducing burdens on a doctor and a nurse due to replacement of a purification liquid bag in the blood purification treatment over a long period of time.SOLUTION: A blood purification system A includes: a blood purification device 1 provided with a blood circuit 11 having a blood purifier 10 and a purification liquid circuit 12 for supplying blood purification liquid to the blood purifier 10 and discharging it; a purification liquid generator 2 for generating the purification liquid; a purification liquid replenishing circuit 3 for connecting the purification liquid generator 2 and the purification liquid circuit 12 in order to replenish the purification liquid generated in the purification liquid generator 2 to the purification liquid bag 50 of the purification liquid circuit 12; and a communication means 4 for performing communication of information between the blood purification device 1 and the purification liquid generator 2 so as to replenish the purification liquid of the purification liquid generator 2 to the purification liquid bag 50 through the purification liquid replenishing circuit 3 when the liquid amount of the purification liquid in the purification liquid bag 50 becomes equal to or smaller than a prescribed threshold.

Description

  The present invention relates to a blood purification system.

  Blood purification therapy is a treatment method in which a patient's blood is taken out of the body, this blood is purified with a blood purifier, and then returned to the body. A typical example is dialysis therapy (Patent Document 1). In dialysis therapy, patient blood and dialysate are brought into contact with each other through a semipermeable membrane of a blood purifier, and unnecessary substances are discharged from the patient blood to the dialysate side using a diffusion phenomenon caused by a difference in substance concentration. Unnecessary large molecular weight substances that cannot be removed only by diffusion are removed by filtration. In addition to dialysis therapy, various blood purification therapies for intractable autoimmune diseases are covered by insurance. For example, by removing leukocytes from patient blood, cases such as ulcerative colitis, Crohn's disease, and rheumatoid arthritis can be dramatically improved (Patent Document 2). Various blood purifiers used for these blood purification treatments also use the adsorptivity to separate substances in addition to the above-described substance separation characteristics such as diffusion and filtration.

  In blood purification therapy, the patient's blood is taken out of the body, the blood is purified with a blood purifier, and then returned to the body. The treatment time is at least 1 hour, usually several hours, depending on the treatment. Dozens of hours are required. In particular, as an example of blood purification therapy that requires long-term treatment, there is a continuous slow blood purification method (Patent Document 3). Continuous slow blood purification methods include various treatment modes such as continuous hemofiltration, continuous hemodialysis, or continuous hemodiafiltration. It is applied to the treatment of renal diseases with multiple complications and multiple organ failure. In both cases, as it is said to be “sustained and slow”, blood purification is usually carried out gradually over a period of one week or more if a single treatment is performed for several days to a long time.

JP 2007-268257 A JP 2010-63761 A JP 2006-025813 A

  By the way, a blood purification apparatus that performs blood purification treatment has a purification liquid bag in which a purification liquid such as dialysate is stored, and the purification liquid bag is suspended from the column of the apparatus, and the blood purification apparatus is connected to the blood purification apparatus. Purified liquid is supplied and blood purification treatment is performed. Therefore, when the purification solution bag becomes empty during the blood purification treatment, it is necessary to replace it with a new purification solution bag.

  As described above, the blood purification treatment takes the patient's blood outside the body, purifies the blood with a blood purifier, and then returns it to the body again. It takes several hours and several tens of hours depending on the treatment. For this reason, it is necessary to exchange the cleaning solution bag a plurality of times during one treatment. In particular, in the above-mentioned continuous slow blood purification therapy, the treatment is continued over a period of one week if it is several days or longer, so that it is necessary to change the purification solution bag many times during the treatment. As a result, the burden on doctors and nurses is large, and the burden increases especially when exchanging at night. In addition, nurses have to be resident so that they can be replaced at night, which increases labor costs and increases the cost of blood purification treatment in hospital management.

  The present invention has been made in view of the above points, and reduces the burden on doctors and nurses due to replacement of the purifying fluid bag in long-term blood purification treatment, and realizes cost reduction of blood purification treatment. Objective.

  To achieve the above object, the present invention provides a blood circuit for supplying blood taken from the body to the blood purifier and returning the blood purified by the blood purifier to the body, and purifying the blood in the blood purifier. A purification liquid circuit for supplying and discharging a liquid, the purification liquid circuit being provided with a purification liquid bag for the purification liquid to be supplied to the blood purifier, and generating the purification liquid The purifying fluid generating device and the purifying fluid generating device and the purifying fluid circuit of the blood purifying device for replenishing the purifying fluid bag of the blood purifying device with the purifying fluid bag of the blood purifying device. When the amount of the purifying liquid in the purifying liquid replenishing circuit to be connected and the purifying liquid bag is equal to or less than a predetermined threshold, the purifying liquid in the purifying liquid generating device is replenished to the purifying liquid bag through the purifying liquid replenishing circuit. The blood purification device Having a communication means for communicating information between said cleaning liquid generating device and a blood purification system.

  According to the present invention, the cleaning liquid can be automatically replenished without replacing the cleaning liquid bag. As a result, the burden on doctors and nurses in blood purification treatment can be reduced, and the cost of blood purification treatment can be reduced.

  In the blood purification system, the purification liquid circuit is provided with a tube pump for sending the purification liquid in the purification liquid bag to the blood purifier, and the purification liquid replenishment circuit is connected to the purification liquid in the purification liquid circuit. It may be connected between the bag and the tube pump.

  The blood purification apparatus has a purification liquid detection unit that detects the amount of the purification liquid in the purification liquid bag, and the communication means determines the amount of the purification liquid in the purification liquid bag detected by the purification liquid detection unit. Based on this, information may be communicated between the blood purification apparatus and the purification liquid generation apparatus so that the purification liquid of the purification liquid generation apparatus is replenished to the purification liquid bag.

  The blood purification system is provided in the purification liquid circuit, and stores a purification waste liquid bag for storing the purification waste liquid discharged from the blood purification device, and for collecting the purification waste liquid in the purification waste liquid bag in the purification liquid generator. A purification waste liquid recovery circuit that connects the purification liquid circuit of the blood purification apparatus and the purification liquid generation apparatus, and the communication means has a liquid amount of the purification waste liquid in the purification waste liquid bag equal to or greater than a predetermined threshold value. When this happens, information is communicated between the blood purification device and the purification solution generator so that the purification waste solution in the purification waste solution bag is collected by the purification solution production device through the purification waste solution collection circuit. It may be a thing.

  The purification liquid circuit is provided with a tube pump for sending the purification waste liquid discharged from the blood purifier to the purification waste liquid bag, and the purification waste liquid recovery circuit includes the purification waste liquid bag in the purification liquid circuit and the It may be connected between the tube pump.

  The blood purification apparatus has a purification waste liquid detection unit that detects the amount of purification waste liquid in the purification waste liquid bag, and the communication unit detects the amount of purification waste liquid in the purification waste liquid bag detected by the purification waste liquid detection unit. On the basis of the above, information communication may be performed between the blood purification device and the purification liquid generation device so that the purification waste liquid in the purification waste liquid bag is collected by the purification liquid generation device.

  The blood purification system is provided in the blood purification device, and supplies a replacement fluid stored in the replacement fluid bag into the blood of the blood circuit, and replenishes the replacement fluid bag from the purification fluid generator. In order to do so, the replacement fluid replenishment circuit that connects the replacement fluid circuit of the blood purification device and the purification fluid generation device, and the communication means, when the amount of the replacement fluid in the replacement fluid bag falls below a predetermined threshold, Information may be communicated between the blood purification apparatus and the purification liquid generating apparatus so that the replacement liquid is replenished to the replacement liquid bag through the replacement liquid replenishment circuit.

  The replacement fluid circuit is provided with a tube pump for sending the replacement fluid in the replacement fluid bag to the blood circuit, and the replacement fluid replacement circuit is connected between the replacement fluid bag and the tube pump in the replacement fluid circuit. Also good.

  The blood purification apparatus includes a replacement fluid detection unit that detects a fluid volume of the replacement fluid in the replacement fluid bag, and the communication unit performs the purification based on the fluid volume of the replacement fluid detected by the replacement fluid detection unit. Communication may be performed between the blood purification apparatus and the purification liquid generation apparatus so that the replacement liquid is replenished to the replacement liquid bag from the liquid generation apparatus.

  The blood purification apparatus may further include a replacement fluid circuit for supplying the purification fluid of the purification fluid circuit as a replacement fluid into the blood of the blood circuit.

Each of the blood purification device and the purification liquid production device is provided with a caster,
Each may be independently movable.

  The blood purification system described above may perform a continuous gradual blood purification process.

  According to the present invention, since the burden on doctors and nurses can be reduced, the cost of blood purification treatment can be reduced.

It is explanatory drawing which shows the outline of a structure of the blood purification system. It is explanatory drawing which shows the outline of a structure of the blood purification system which has a purification waste liquid collection circuit. It is explanatory drawing which shows the outline of a structure of the blood purification system which has a replacement fluid replenishment circuit. It is explanatory drawing which shows the outline of a structure of the blood purification system by which the replacement fluid replenishment circuit is connected to the purification liquid circuit.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. FIG. 1 is an explanatory diagram showing an outline of the configuration of blood purification system A according to the present embodiment.

  The blood purification system A includes a blood purification apparatus 1 that performs blood purification processing, a purification liquid generation apparatus 2 that generates a purification liquid such as dialysate used for blood purification processing, and a purification liquid generated by the purification liquid generation apparatus 2. A purification liquid replenishment circuit 3 for replenishing the blood purification apparatus 1 and a communication means 4 for communicating information between the blood purification apparatus 1 and the purification liquid generation apparatus 2 are provided.

  The blood purification apparatus 1 supplies, for example, blood extracted from the body to the blood purifier 10, and returns the blood purified by the blood purifier 10 to the body, and the blood purifier 10 supplies blood to the blood purifier 10. A purification liquid circuit 12 for supplying and discharging a purification liquid, a replacement fluid circuit 13 for supplying a replacement fluid into the blood of the blood circuit 11, and a control device 14 for controlling the operation of various circuits and devices of the blood purification device 1. have.

  The blood circuit 11 is, for example, a tube-shaped channel, and a blood flow channel 21 to which the blood purifier 10 is connected from the blood sampling puncture unit 20, and a return blood flow connected to the blood return puncture unit 22 from the blood purifier 10. A path 23 is provided. The blood collection channel 21 is provided with a tube pump 30 that handles the tube of the channel from the outside and feeds it. In the blood return channel 23, for example, a drip chamber 31 for discharging bubbles is provided.

  The blood purifier 10 has, for example, a hollow fiber membrane 40 as a purification membrane, and blood flows to the primary side 41 of the hollow fiber membrane 40. A purification liquid flows on the secondary side 42 of the hollow fiber membrane 40.

  The purifying fluid circuit 12 includes, for example, a tubular purifying fluid supply channel 51 connected from the purifying fluid bag 50 to the secondary side 42 of the blood purifier 10, and a purifying waste fluid bag 52 from the secondary side 42 of the blood purifier 10. A tubular purification waste liquid discharge flow channel 53 connected to the. The purification liquid bag 50 and the purification waste liquid bag 52 are suspended from, for example, a support column (not shown) in the apparatus.

  The purified liquid supply channel 51 is provided with a tube pump 60, and the purified waste liquid discharge channel 53 is provided with a tube pump 61. By driving the tube pumps 60, 61, the purifying liquid in the purifying liquid bag 50 is supplied to the secondary side 42 of the blood purifier 10 through the purifying liquid supply flow channel 51, and in the blood from the primary side 41 in the blood purifier 10. The purification waste liquid incorporating the unnecessary substances is discharged to the purification waste liquid bag 52 through the purification waste liquid discharge channel 53.

  The replacement fluid circuit 13 is connected to the blood return channel 23 from the replacement fluid bag 70, for example. A tube pump 71 is provided in the replacement fluid circuit 13. By driving the tube pump 71, the replacement fluid in the replacement fluid bag 70 is supplied to the blood return channel 23 through the replacement fluid circuit 13. Thereby, the blood after purification can be supplemented with a replacement fluid such as water.

  The cleaning liquid bag 50 is provided with a weight meter 80 as a cleaning liquid detection unit, and the amount of liquid in the cleaning liquid bag 50 can be detected. The detection result of the liquid amount by the weigh scale 80 is output to the control device 14.

  The control device 14 can control the operations of the tube pumps 30, 60, 61, 71, etc. to execute blood purification processing. Further, the control device 14 can detect whether or not the liquid amount in the purifying liquid bag 50 has become equal to or lower than a predetermined lower threshold by monitoring the liquid amount in the purifying liquid bag 50 with the weight meter 80.

  The purification liquid generator 2 includes, for example, two raw material tanks 90 and 91 in which a raw material of the purification liquid is stored, a solvent tank 92 in which a solvent such as water to be added to the raw material is stored, and a mixing tank that mixes the raw material and the solvent 93, a purification liquid generation circuit 94 for sending raw materials and solvents from the raw material tanks 90 and 91 and the solvent tank 92 to the mixing tank 93, a control device 95 for controlling various circuits and devices of the purification liquid generation apparatus 2, and the like. is doing.

  For example, the purification liquid generation circuit 94 is provided with valves 96, 97, and 98. By opening these valves 96 to 98, supply of raw materials from the raw material tanks 90 and 91 to the mixing tank 93, solvent tank The solvent can be supplied from 92 to the mixing tank 93.

  The control device 95 can control, for example, the generation or stop of generation of the purification solution by opening and closing the valves 96 to 98, and the replenishment of the purification solution to the blood purification device 1 by the tube pump 100 described later and the stop of the supply.

  The purification liquid replenishment circuit 3 is formed, for example, in a tube shape, and is connected from the mixing tank 93 of the purification liquid generation apparatus 2 to the purification liquid supply flow path 51 of the blood purification apparatus 1. The purification liquid replenishment circuit 3 is connected between, for example, the tube pump 60 and the purification liquid bag 50 in the purification liquid supply channel 51. A tube pump 100 is provided in the cleaning liquid replenishment circuit 3. The tube pump 100 is provided in the purification liquid production | generation apparatus 2, for example. The purification liquid replenishment circuit 3 is configured to be connectable and separable at any part so that the blood purification apparatus 1 and the purification liquid production apparatus 2 can be connected and disconnected.

  The communication unit 4 includes, for example, communication units 110 and 111 that serve as interfaces for information communication in the blood purification device 1 and the purification liquid generation device 2, respectively. The communication units 110 and 111 can communicate with each other by wire or wirelessly. In the case of a wired connection, the information line can be connected and disconnected between the communication units 110 and 111 so that the blood purification device 1 and the purification liquid generating device 2 can be connected and disconnected. The communication means 4 replenishes the purifying liquid bag 50 with the purifying liquid of the purifying liquid generating device 2 through the purifying liquid replenishing circuit 3 when the amount of the purifying liquid in the purifying liquid bag 50 becomes a predetermined lower limit threshold or less. As described above, signals are exchanged between the blood purification apparatus 1 and the purification liquid generation apparatus 2.

  Specifically, when the control device 14 of the blood purification device 1 monitors the weight of the purification solution bag 50 by the weight scale 80, and the amount of the purification solution in the purification solution bag 50 becomes a predetermined lower limit threshold or less. The liquid amount reduction information of the purification liquid is output from the control device 14 to the communication unit 110. The communication unit 110 transmits the liquid amount reduction information to the communication unit 111 on the purification liquid generating device 2 side, and the communication unit 111 outputs the information to the control device 95. The control device 95 drives the tube pump 100 based on the liquid amount lowering information, and replenishes the purification solution bag 50 from the purification solution generator 2. In addition, when the amount of the cleaning liquid in the cleaning liquid bag 50 reaches a predetermined upper limit threshold, the upper limit information of the cleaning liquid is output from the control device 14 to the communication unit 110. The communication unit 110 transmits the liquid amount upper limit information to the communication unit 111 on the purification liquid generating device 2 side, and the communication unit 111 outputs the information to the control device 95. The control device 95 stops the tube pump 100 based on the liquid amount upper limit information, and stops the replenishment of the purifying liquid from the purifying liquid generating device 2 to the purifying liquid bag 50.

  For example, the blood purification apparatus 1 and the purification liquid production apparatus 2 are each provided with a caster 115, and each can move independently.

  Next, an example of operation | movement of the blood purification system A comprised as mentioned above is demonstrated. The tube pumps 30, 60, 61, 71 operate in the continuous gradual blood purification process. Thereby, the blood of the patient is sent from the blood collection puncture unit 20 to the primary side 41 of the blood purifier 10 through the blood collection channel 21. In addition, a purification solution that is a dialysis solution is sent from the purification solution bag 50 to the secondary side 42 of the blood purification device 10 through the purification solution supply channel 51. In the blood purifier 10, unnecessary substances in the blood on the primary side 41 pass through the hollow fiber membrane 40 by the osmotic pressure and flow into the secondary side 42 to purify the blood. The purified blood is returned to the patient from the blood return puncture unit 22 through the blood return channel 23. Further, the purified waste liquid that has taken in unnecessary substances on the secondary side 42 of the blood purifier 10 is stored in the purified waste liquid bag 52 through the purified waste liquid discharge circuit 53. Further, from the replacement fluid bag 70, the replacement fluid is supplied into the blood of the blood return circuit 23 through the replacement fluid circuit 13, and the reduced amount of water in the blood is replenished by the blood purifier 10.

  During the blood purification process, the weight of the purification liquid is monitored in the purification liquid bag 50 by the weight meter 80. Then, when the amount of the purifying liquid in the purifying liquid bag 50 becomes equal to or less than a predetermined lower threshold, the liquid amount lowering information is sent from the communication unit 110 to the communication unit 111. In the purified liquid generating apparatus 2 that has received the liquid amount reduction information of the purified liquid, the tube pump 100 is driven, and the purified liquid in the mixing tank 93 is sent to the purified liquid supply channel 51. In the purification liquid supply flow path 51, the flow toward the blood purifier 10 side is restricted by the tube pump 60, so the purification liquid that has flowed into the purification liquid supply flow path 51 flows into the purification liquid bag 50. At this time, for example, the tube pump 60 continues to operate, and the blood purification process is not interrupted. Then, when the amount of the purification liquid in the purification liquid bag 50 reaches the predetermined upper limit threshold, the liquid amount upper limit information is sent from the communication unit 110 to the communication unit 111, and the tube pump 100 is stopped. Thereby, supply of the purification liquid from the purification liquid production | generation apparatus 2 to the blood purification apparatus 1 is stopped, and replenishment of the purification liquid to the purification liquid bag 50 is complete | finished.

  According to the present embodiment, it is possible to automatically replenish the purifying liquid without replacing the purifying liquid bag 50 by connecting the purifying liquid generating apparatus 2 to the blood purifying apparatus 1. This eliminates the need for a person to replace the cleaning solution bag 50 during blood purification treatment, reduces the burden on doctors and nurses in long-time blood purification treatment, and realizes cost reduction of blood purification treatment.

  Further, according to the present embodiment, the purification liquid replenishment circuit 3 is connected between the purification liquid bag 50 and the tube pump 60 in the purification liquid circuit 12. As a result, the tube pump 60 restricts the flow of the purifying fluid circuit 12 toward the blood purifier 10, so that, for example, the purifying fluid replenishing circuit 3 is connected to the purifying fluid circuit 12 without being directly connected to the purifying fluid bag 50. Thus, the cleaning liquid can be suitably replenished. As a result, the purifying solution bag 50 having a conventionally used structure can be used as it is. Further, since the space between the tube pump 60 and the purifying fluid bag 50 is a closed system, the purifying fluid bag 50 is purified while the tube pump 60 is operated and a predetermined amount of purifying fluid is supplied to the blood purifier 10. The liquid can be replenished. Therefore, since the purification solution can be replenished without interrupting the blood purification treatment, the time for blood purification treatment can be shortened and the burden on the patient can be reduced. The purification liquid replenishment circuit 3 is not necessarily connected between the purification liquid bag 50 and the tube pump 60 in the purification liquid circuit 12, and may be directly connected to the purification liquid bag 50. Further, the blood purification process may be temporarily interrupted to replenish the purification liquid.

  According to the present embodiment, the purification liquid bag 50 is provided with the weight meter 80, and the communication unit 4 determines the purification liquid generator 2 based on the amount of the purification liquid in the purification liquid bag 50 detected by the weight meter 80. Since the information is communicated between the blood purification device 1 and the purification solution generator 2 so that the purification solution 50 is replenished in the purification solution bag 50, the purification solution is replenished to the purification solution bag 50 at an appropriate timing. Can be suitably performed.

  The blood purification apparatus 1 and the purification liquid generation apparatus 2 are each provided with a caster 115 and can be moved independently of each other, so that the blood purification apparatus 1 and the purification liquid generation apparatus 2 are separated and moved individually. Can be made. Thereby, the blood purification apparatus 1 and the purification liquid production | generation apparatus 2 can be attached or detached as needed.

  Note that the generation of the purification liquid in the purification liquid generator 2 may be performed as appropriate when, for example, the amount of liquid in the mixing tank 93 is reduced, or may be performed when the purification liquid bag 80 is replenished with the purification liquid. Okay, both.

  In the above embodiment, as shown in FIG. 2, the blood purification system A collects the purification waste liquid in the purification waste liquid bag 52 in the purification liquid generator 2, so that the purification liquid circuit 12 and the purification liquid of the blood purification apparatus 1 are used. You may further have the purification waste liquid collection circuit 120 which connects the production | generation apparatus 2. FIG. The purified waste liquid recovery circuit 120 is connected to the purified waste liquid discharge channel 53 from, for example, a purified waste liquid tank 121 provided in the purified liquid generator 2. The purified waste liquid recovery circuit 120 is connected between the purified waste liquid bag 52 and the tube pump 61. The purified waste liquid recovery circuit 120 is provided with a tube pump 122. The purification waste liquid bag 52 is provided with a weighing scale 123 as a purification waste liquid detection unit that detects the amount of the purification waste liquid in the bag. The measurement result by the weigh scale 123 is output to the control device 14.

  During the blood purification process, the weight of the purified waste liquid in the purified waste liquid bag 52 is monitored by the weight scale 123. When the amount of the purified waste liquid in the purified waste liquid bag 52 becomes equal to or greater than a predetermined upper limit threshold value, the liquid amount increase information is sent from the communication unit 110 to the communication unit 111. In the purified liquid generating apparatus 2 that has received the information on the increase in the amount of the purified waste liquid, the tube pump 122 is operated, and the purified waste liquid in the purified waste liquid bag 52 is transferred to the purified waste liquid tank 121 through the purified waste liquid discharge channel 53 and the purified waste liquid recovery circuit 120. Sent. At this time, the tube pump 61 continues to operate, and for example, the blood purification process is not interrupted. When the amount of the purified waste liquid in the purified waste liquid bag 52 reaches a predetermined lower limit threshold, the lower limit liquid amount information is sent from the communication unit 110 to the communication unit 111, and the tube pump 122 is stopped. Thereby, collection | recovery of the purification waste liquid from the blood purification apparatus 1 to the purification liquid production | generation apparatus 2 is stopped.

  According to such an example, since the purification waste liquid in the purification waste liquid bag 52 can be automatically collected, there is no need to replace the purification waste liquid bag 50, and the burden on doctors and nurses in the long-time blood purification treatment is reduced. it can.

  Further, the purified waste liquid recovery circuit 120 is connected between the purified waste liquid bag 52 and the tube pump 61 in the purified liquid circuit 12. As a result, the tube pump 61 regulates the flow of the purified waste liquid discharge circuit 53 toward the purified waste liquid bag 52, so that the purified waste liquid recovery circuit 120 can be connected to the purified waste liquid discharge circuit 53 without being directly connected to the purified waste liquid bag 52. Thus, the purification waste liquid can be suitably recovered. As a result, the purification waste liquid bag 52 having a structure conventionally used can be used as it is. Further, since the space between the tube pump 61 and the purification waste liquid bag 52 is a closed system, the purification waste liquid is collected from the purification waste liquid bag 52 while the tube pump 61 is operated and the purification waste liquid is discharged from the blood purifier 10. it can. Therefore, since the washing waste liquid can be collected without interrupting the blood purification treatment, the time for blood purification treatment can be shortened and the burden on the patient can be reduced. The purified waste liquid recovery circuit 120 does not necessarily need to be connected between the purified waste liquid bag 52 and the tube pump 61 in the purified liquid circuit 12, and may be directly connected to the purified waste liquid bag 52. Further, the blood purification treatment may be temporarily interrupted to collect the purification waste liquid.

  In addition, according to the present embodiment, the purification waste liquid bag 52 is provided with the weight scale 123, and the communication means 4 is based on the amount of the purification waste liquid in the purification waste liquid bag 52 detected by the weight scale 123. Since the information is communicated between the blood purification device 1 and the purification liquid generation device 2 so that the purification waste liquid 52 is recovered by the purification liquid generation device 2, the recovery of the purification waste liquid from the purification waste liquid bag 52 is performed. It can be suitably performed at an appropriate timing.

  In addition, the purification liquid production | generation apparatus 2 does not necessarily need to be equipped with the purification waste liquid tank 121, and may be connected to the external drainage line from the purification waste liquid collection circuit 120. In such a case, the purified waste liquid collected by the purified liquid generator 2 is sent to an external drain line and drained.

  In the above embodiment, for example, as shown in FIG. 3, the blood purification system A replenishes the replacement fluid to the replacement fluid bag 70 of the blood purification device 1 from the purification fluid generation device 2, and the replacement fluid circuit 13 and the purification fluid generation device. 2 may be provided. The replacement fluid replenishment circuit 130 is connected to the replacement fluid circuit 13 from a replacement fluid tank 131 provided in the purification fluid generator 2, for example. The replacement fluid replenishment circuit 130 is connected between the replacement fluid bag 70 and the tube pump 71. A tube pump 132 is provided in the replacement fluid replenishment circuit 130. The replacement fluid bag 71 is provided with a weight scale 133 as a replacement fluid detection unit that detects the amount of replacement fluid in the bag. The measurement result by the weight scale 133 is output to the control device 14.

  During the blood purification process, the weight of the replacement fluid in the replacement fluid bag 70 is monitored by the weight scale 133. When the amount of the replacement fluid in the replacement fluid bag 70 becomes equal to or less than a predetermined lower threshold value, the fluid amount decrease information is sent from the communication unit 110 to the communication unit 111 side. In the purifying fluid generating apparatus 2 that has received the fluid lowering information of the replacement fluid, the tube pump 132 is operated, and the replacement fluid in the replacement fluid tank 131 is sent to the replacement fluid bag 70 through the replacement fluid replacement circuit 130 and the replacement fluid circuit 13. At this time, for example, the tube pump 71 continues to operate, and the blood purification process is not interrupted. When the amount of the replacement fluid in the replacement fluid bag 70 reaches the predetermined upper limit threshold, the upper limit fluid amount information is sent from the communication unit 110 to the communication unit 111, and the tube pump 132 is stopped. As a result, the supply of the replacement fluid from the purification fluid generator 2 to the blood purification device 1 is stopped, and the replacement of the replacement fluid to the replacement fluid bag 70 is stopped.

  According to this example, since the replacement fluid in the replacement fluid bag 70 can be automatically replenished, it is not necessary to replace the replacement fluid bag 70, and the burden on doctors and nurses in the long-time blood purification treatment can be reduced.

  The replacement fluid replenishment circuit 130 is connected between the replacement fluid bag 70 and the tube pump 71 in the replacement fluid circuit 13. As a result, the tube pump 71 restricts the flow of the replacement fluid circuit 13 on the blood circuit 11 side, so that the replacement fluid replenishment circuit 130 is connected directly to the replacement fluid circuit 13 without being connected directly to the replacement fluid bag 70, and the replacement fluid is preferably replenished. it can. As a result, the replacement bag 70 having a structure used conventionally can be used as it is. In addition, since the space between the tube pump 71 and the replacement fluid bag 70 is a closed system, the replacement fluid bag 70 can be replenished while the tube pump 71 is operated and the replacement fluid is supplied to the blood circuit 11. Therefore, since the replacement fluid can be replenished without interrupting the blood purification treatment, the time for blood purification treatment can be shortened and the burden on the patient can be reduced. Note that the replacement fluid replenishment circuit 130 is not necessarily connected between the replacement fluid bag 70 and the tube pump 71 in the replacement fluid circuit 13, and may be directly connected to the replacement fluid bag 70. Further, the blood purification process may be temporarily interrupted to replenish the replacement fluid.

  According to this embodiment, the replacement fluid bag 70 is provided with the weigh scale 133, and the communication means 4 sends the replacement fluid bag from the purified solution generator 2 based on the amount of the replacement fluid in the replacement fluid bag 70 detected by the weight meter 133. Since communication is performed between the blood purification apparatus 1 and the purification liquid generating apparatus 2 so that the replacement fluid is replenished to the replacement fluid 70, the replacement fluid can be suitably supplemented to the replacement fluid bag 70 at an appropriate timing.

  In addition, the purification liquid production | generation apparatus 2 does not necessarily need to be provided with the replacement fluid tank 131, for example, when a purification fluid can be used as a replacement fluid, the replacement fluid replenishment circuit 130 may be connected to the mixing tank 93. .

  As shown in FIG. 4, the replacement fluid circuit 13 may supply the purification fluid from the purification fluid circuit 12 as a replacement fluid into the blood of the blood circuit 11. In this case, the replacement fluid circuit 13 is connected to the blood return passage 23 of the blood circuit 11 from the purification fluid supply passage 51 between the tube pump 61 of the purification fluid circuit 12 and the purification fluid bag 50. In this case, the replacement fluid circuit 13 does not require a separate replacement fluid bag. At the time of blood purification processing, the tube pump 71 is driven to supply a cleaning fluid as a replacement fluid from the cleaning fluid bag 50 to the blood return passage 23 through the cleaning fluid supply channel 51 and the replacement fluid circuit 13 to supply the replacement fluid into the blood. Is done. Further, when the purifying liquid in the purifying liquid bag 50 is reduced as described above, the purifying liquid can be replenished by replenishing the purifying liquid bag 50 from the purifying liquid generating device 2. Therefore, the replacement fluid can be automatically replenished.

  The preferred embodiments of the present invention have been described above with reference to the accompanying drawings, but the present invention is not limited to such examples. It is obvious for those skilled in the art that various modifications or modifications can be conceived within the scope of the idea described in the claims, and these naturally belong to the technical scope of the present invention. It is understood.

  For example, in the above-described embodiment, the weigh scale is used as the purification liquid detection unit, the purification waste liquid detection unit, and the replacement fluid detection unit, but is not limited thereto, and other detectors such as an empty detector and a liquid level sensor are used. It may be used. Moreover, in the said embodiment, although the separate weighing scale was used as a purification | cleaning liquid detection part or a purification | cleaning waste liquid detection part, you may use the same weighing scale. In such a case, for example, a detector such as an empty detector for detecting that the purifying liquid bag is empty and a liquid level sensor for detecting that the amount of the purifying liquid bag has decreased to a certain value is used in combination. Then, the amount of the purifying solution bag is grasped by this detector, and the amount of the purifying waste solution bag is calculated from the amount of the purifying solution bag and the total weight of the weigh scale. Or, combined with a calculation means that calculates that the purification waste liquid bag is full from the pump rotation speed, and a detector for the liquid level sensor that detects that the amount of the purification waste liquid bag has increased to a certain value To do. Then, the liquid amount of the purified waste liquid bag is grasped by the calculation means and the detector, and the liquid volume of the purified liquid bag is calculated from the liquid volume of the purified waste liquid bag and the total weight by the weigh scale.

  The pumps 100, 122, and 132 described in the above embodiments are not limited to tube pumps, and may be other metering pumps such as a plunger pump (piston system). Further, the tube pumps 100 and 122 may be double tube pumps that handle and send two tubes. Further, the circuit configurations of the blood purification device 1 and the purification liquid generation device 2 in the above embodiment are not limited to these. Further, the configuration of the communication means 4 is not limited to that of the above-described embodiment, and any other configuration may be used as long as communication can be performed between the blood purification device 1 and the purified liquid generating device 2. Moreover, although the above embodiment was the blood purification system 1 which performs a continuous hemodialysis method, as long as a purification liquid is used, various continuous processes, such as a continuous blood filtration method and a continuous blood filtration dialysis method, are carried out. The present invention can be applied to those performing a slow blood purification method. The present invention may also be applied to blood purification treatments other than the continuous gradual blood purification method.

A blood purification system 1 blood purification apparatus 2 purification liquid generation apparatus 3 purification liquid replenishment circuit 4 communication means 10 blood purifier 11 blood circuit 12 purification liquid circuit 13 replacement fluid circuit 14 control device 20 blood collection puncture section 21 blood collection flow path 22 blood return puncture Part 23 Blood return path 30 Tube pump 31 Drip chamber 40 Hollow fiber membrane 41 Primary side 42 Secondary side 50 Purified liquid bag 51 Purified liquid supply flow path 52 Purified waste liquid bag 53 Purified waste liquid discharge flow path 60 Tube pump 61 Tube pump 70 Replacement fluid bag 71 Tube pump 80 Weigh scale 90, 91 Raw material tank 92 Solvent tank 93 Mixing tank 94 Purified liquid generation circuit 95 Controller 96, 97, 98 Valve 100 Tube pump 110, 111 Communication unit 115 Caster 120 Purified waste liquid recovery circuit 121 Purification Waste liquid tank 122 Yubuponpu 123 weigh scale 130 replacement fluid refill circuit 131 replacement fluid tank 132 tube pump 133 weighing scale

Claims (12)

A blood circuit for supplying blood taken from the body to the blood purifier, returning the blood purified by the blood purifier to the body, and a purifying fluid circuit for supplying and discharging blood purifying fluid to the blood purifier A blood purification apparatus, wherein the purification liquid circuit is provided with a purification liquid bag for the purification liquid supplied to the blood purification device;
A purification liquid generator for generating the purification liquid;
A purifying fluid replenishing circuit for connecting the purifying fluid generating device and the purifying fluid circuit of the blood purifying device in order to replenish the purifying fluid generated by the purifying fluid generating device to the purifying fluid bag of the blood purifying device; ,
Purifying the blood so that the purifying liquid of the purifying liquid generating device is replenished to the purifying liquid bag through the purifying liquid replenishing circuit when the amount of the purifying liquid in the purifying liquid bag falls below a predetermined threshold. A blood purification system comprising: a communication unit configured to communicate information between the apparatus and the purification liquid generation apparatus. The purification liquid circuit is provided with a tube pump for sending the purification liquid in the purification liquid bag to the blood purification device,
The blood purification system according to claim 1, wherein the purification liquid replenishment circuit is connected between the purification liquid bag and the tube pump in the purification liquid circuit. The blood purification apparatus has a purification liquid detection unit for detecting the amount of the purification liquid in the purification liquid bag,
The blood purification means is configured to replenish the purifying liquid bag with the purifying liquid of the purifying liquid generating device based on the amount of the purifying liquid in the purifying liquid bag detected by the purifying liquid detecting unit. The blood purification system according to claim 1 or 2, wherein information is communicated between the apparatus and the purification liquid production apparatus. A purification waste liquid bag that is provided in the purification liquid circuit and stores the purification waste liquid discharged from the blood purifier,
A purification waste liquid recovery circuit for connecting the purification liquid circuit of the blood purification device and the purification liquid generation device in order to recover the purification waste liquid of the purification waste liquid bag to the purification liquid generation device;
The communication means may recover the purification waste liquid in the purification waste liquid bag to the purification liquid generator through the purification waste liquid recovery circuit when the amount of the purification waste liquid in the purification waste liquid bag exceeds a predetermined threshold. Furthermore, the blood purification system in any one of Claims 1-3 which communicates information between the said blood purification apparatus and the said purification liquid production | generation apparatus. The purification liquid circuit is provided with a tube pump for sending the purification waste liquid discharged from the blood purifier to the purification waste liquid bag,
The blood purification system according to claim 4, wherein the purification waste liquid recovery circuit is connected between the purification waste liquid bag and the tube pump in the purification liquid circuit. The blood purification apparatus has a purification waste liquid detection unit that detects the amount of purification waste liquid in the purification waste liquid bag,
The blood purification unit is configured to collect the purification waste liquid in the purification waste liquid bag in the purification liquid generation device based on the amount of the purification waste liquid in the purification waste liquid bag detected by the purification waste liquid detection unit. The blood purification system according to claim 4 or 5, wherein information is communicated between the apparatus and the purification liquid production apparatus. A replacement fluid circuit provided in the blood purification device for supplying the replacement fluid stored in the replacement fluid bag into the blood of the blood circuit;
A replacement fluid replenishment circuit for connecting the replacement fluid circuit of the blood purification device and the purification fluid generation device in order to replenish the replacement fluid bag from the purification fluid generator;
The communication means includes the blood purification device and the generation of the purification liquid so that the replacement fluid is replenished to the replacement fluid bag through the replacement fluid replenishment circuit when the amount of the replacement fluid in the replacement fluid bag becomes a predetermined threshold value or less. The blood purification system according to any one of claims 1 to 6, wherein information is communicated with an apparatus. The replacement fluid circuit is provided with a tube pump for sending the replacement fluid in the replacement fluid bag to the blood circuit,
The blood purification system according to claim 1, wherein the replacement fluid replenishment circuit is connected between the replacement fluid bag and the tube pump in the replacement fluid circuit. The blood purification device has a replacement fluid detection unit that detects the amount of replacement fluid in the replacement fluid bag,
The communication means includes the blood purification device and the purification solution so that the replacement fluid is replenished to the replacement fluid bag from the purification solution generator based on the amount of the replacement fluid in the replacement fluid bag detected by the replacement fluid detection unit. The blood purification system according to claim 7 or 8, wherein communication is performed with a generation device.   The blood purification system according to any one of claims 1 to 6, wherein the blood purification device further includes a replacement fluid circuit for supplying the purification fluid of the purification fluid circuit as a replacement fluid into the blood of the blood circuit. Each of the blood purification device and the purification liquid production device is provided with a caster,
The blood purification system according to any one of claims 1 to 10, wherein each of them can move independently. The blood purification system according to any one of claims 1 to 11,
A blood purification system that performs continuous gradual blood purification.

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