JP2010143846A - Dentifrice composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a pentylene glycol-containing dentifrice composition that hardly has an odd taste, slightly has an odd taste feel during or after use, has excellent sense of use, excellent shape retention and stability of paste skin with time after low-temperature preservation. <P>SOLUTION: The dentifrice composition is obtained by mixing (A) a pentylene glycol-containing dentifrice composition with (B) 0.1-2.0 mass% of sodium carboxymethylcellulose and (C) 0.1-15 mass% of trimethylglycine in the mass ratio of (C)/(B) of 0.1-8.0. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a dentifrice composition containing pentylene glycol that has reduced bitterness due to the blending of pentylene glycol, has less off-taste, has good shape retention, and is excellent in suppressing the deterioration of kneaded skin after low-temperature storage.

  Conventionally, when pentylene glycol is blended into an oral composition for the purpose of preserving or the like, pentylene glycol exhibits a bitter taste in the composition, and the bitter taste cannot be sufficiently masked with a fragrance, etc. Become. Therefore, it is necessary to improve the off-taste derived from pentylene glycol from the point of view of commercial value, but it is difficult to satisfactorily improve by the conventional technology, and therefore, oral compositions containing pentylene glycol are not often used. Was the current situation.

  Technology for reducing bitterness by blending a polyoxyethylene polyoxypropylene copolymer with an oral composition containing pentylene glycol (Patent Document 1), and also polyhydric alcohols such as pentylene glycol and alkyl paraoxybenzoate A mouthwash (Patent Document 2) having excellent antiseptic properties and feeling of use without using a bactericide has been proposed by using an ester in combination, but a more effective bitterness improving technique is desired.

  On the other hand, carboxymethylcellulose sodium is inexpensive and widely used as a binder in dentifrice compositions, and is widely used as a compounding ingredient in dentifrice compositions. However, sodium carboxymethylcellulose is used in dentifrice compositions formulated with pentylene glycol. It has been found that there is a problem that the kneaded skin in low-temperature storage deteriorates when blended.

  Therefore, there is a need for a technique that can solve the above-described problems, effectively improve the bitterness derived from pentylene glycol, and satisfy satisfactory low-temperature storage stability at the same time in a dentifrice composition containing pentylene glycol.

JP 2000-169351 A JP 2000-53546 A Japanese Patent Laid-Open No. 9-25221 JP-T-2001-508423 Acta Odontol Scan (2002), 60 (5), p306-310 J Contemp Dent Pract (2003), 4 (2), p11-23

  The present invention has been made in view of the above circumstances, and provides a dentifrice composition that has almost no off-taste derived from pentylene glycol, has good shape retention, and is excellent in suppressing the deterioration of kneaded skin after low-temperature storage. The purpose is to do.

  As a result of intensive studies to achieve the above object, the present inventors have formulated pentylene glycol by blending sodium carboxymethylcellulose and trimethylglycine at a specific ratio into a dentifrice composition containing pentylene glycol. The bitterness derived from it is reduced, the user hardly feels a strange taste during and after using the dentifrice composition, and it has excellent shape retention, and there is no deterioration of the kneaded skin after low-temperature storage, stable at low-temperature storage As a result, the inventors have found that the properties are also good, and have made the present invention.

According to the present invention, by using carboxymethylcellulose sodium and trimethylglycine in an appropriate ratio in combination with pentylene glycol, these components act synergistically, as will be apparent from the examples described later, and pentylene glycol. The bitterness of the origin is reduced without special masking, such as by adding special fragrances, etc., and there is almost no unpleasant taste during and after use of the dentifrice composition, and an excellent feeling of use is obtained It is done. Furthermore, when carboxymethylcellulose sodium is added to the dentifrice composition containing pentylene glycol, there is a problem that the kneaded skin deteriorates during low-temperature storage. By doing so, such problems as deterioration of the kneaded skin are also eliminated, there is almost no off-taste, and kneaded skin deterioration after low-temperature storage is suppressed, and a product having excellent shape retention can be obtained.
Such an effect of the present invention is that when carboxymethylcellulose sodium or trimethylglycine is blended with pentylene glycol, or even when carboxymethylcellulose sodium and trimethylglycine are used in combination, the blending amount and blending ratio of each component are inappropriate. In other cases, it cannot be achieved, and can be achieved by satisfying any of the essential components of the present invention.

  In addition to trimethylglycine, trimethylglycine is called glycine betaine and betaine, and is a known substance that is widely used as an amino acid-based moisturizing agent in skin cosmetics, hair cosmetics, and the like. It is also known as a compounding component for oral compositions, and as an example of application to the oral cavity, the effect of removing plaque by using in combination with various enzymes has been reported (see Patent Document 3). Further, Non-Patent Document 1 reports the effect of suppressing the stimulation of the active agent on the oral mucosa, and further reports the moisturizing effect of the oral mucosa as well as on the skin (Patent Document 4, Non-Patent Document 2). reference). In this way, the moisturizing effect of trimethylglycine on the skin and oral mucosa is known, but when applied to a dentifrice composition and combined with a specific component, it exhibits a taste-reducing effect derived from the specific component, It is not known that kneaded skin and shape retention after low-temperature storage are also improved.

  Therefore, the present invention provides (A) a dentifrice composition containing pentylene glycol, (B) 0.1 to 2.0% by mass of sodium carboxymethylcellulose, and (C) trimethylglycine of 0.1 to 15%. A dentifrice composition characterized by comprising (C) / (B) in a mass ratio of 0.1 to 8.0.

  The dentifrice composition containing pentylene glycol of the present invention has almost no off-taste even if it is not specifically masked with a fragrance or the like. It has good moldability and is excellent in stability over time of kneaded skin after low-temperature storage, and can be prepared in various dosage forms and used widely.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention is prepared into a paste, gel, liquid, etc., and is used for toothpastes such as toothpaste, liquid dentifrice, liquid dentifrice, and particularly paste-like. And (A) pentylene glycol, (B) sodium carboxymethylcellulose, and (C) trimethylglycine.

(A) Pentylene glycol is a kind of aliphatic dihydric alcohol, and has a structure in which two hydroxyl groups are bonded to a hydrocarbon. The α-type, β-type, etc. Among them, in particular, those having a hydroxyl group on adjacent carbon, which is called α-type, are generally used in cosmetics and the like for the purpose of retaining moisture.
In the dentifrice composition of the present invention, any structure can be used as long as it is pentylene glycol, but α-type pentylene glycol is particularly preferable, and 1,2-pentanediol is particularly preferable. As pentylene glycol, a commercial item can be used, for example, a reagent manufactured by Tokyo Chemical Industry Co., Ltd., diol PD (trade name) sold by Higher Alcohol Industry Co., Ltd., and the like can be used.

  The content of pentylene glycol is preferably 0.2 to 15% (mass%, the same shall apply hereinafter), particularly 0.2 to 10%, particularly 0.5 to 5% of the entire composition. If the content is less than 0.2%, the antiseptic effect may not be obtained, and if it exceeds 15%, an off-taste may develop during use or after use, or the shape retention may deteriorate.

(B) As carboxymethylcellulose sodium, those having an average substitution degree (DS conversion degree) of carboxymethyl group of 0.5 to 1.5 are easily available and can be suitably used.
Sodium carboxymethylcellulose has a viscosity of 15 to 3,000 mPa · s (2% aqueous solution, measured with a B-type viscometer at 20 ° C., the same applies hereinafter), particularly 750 to 1,050 mPa in order to maintain the shape retention. -The thing of s is suitable. When the viscosity is lower than 15 mPa · s, the shape-retaining property is poor, and the dentifrice composition may sag from the toothbrush, and when it exceeds 3,000 mPa · s, the viscosity of the preparation becomes too high, and the skin is reduced. There is a case.

  In addition, the said viscosity is the value measured using the rotor of No. 1-4 according to a viscosity range using B8H type viscometer (for example, Tokyo Keiki Co., Ltd. product). When the viscosity is less than 100 mPa · s, the viscosity after 3 minutes at 50 rpm using the No. 1 rotor, and when the viscosity is 100 mPa · s or more, after 3 minutes at 20 rpm using the No. 1-4 rotor The viscosity of was measured.

  Examples of such sodium carboxymethylcellulose include commercially available products such as CMC Daicel (trade name) sold by Daicel Chemical Industries, Ltd.

  The amount of sodium carboxymethylcellulose is 0.1 to 2.0% of the total composition, preferably 0.5 to 1.5%. If it is less than 0.1%, the shape retention is inferior. From the toothbrush to the dentifrice composition Things may sag, and if it exceeds 2.0%, the kneaded skin will deteriorate over time due to polymer entanglement.

The dentifrice composition of the present invention further contains trimethylglycine. Combined use of sodium carboxymethylcellulose and trimethylglycine can improve taste (bitterness), deterioration of kneaded skin after low-temperature storage, and shape retention.
Trimethylglycine (N, N, N-trimethylglycine) is a naturally occurring quaternary ammonium compound extracted from sugar radish and is known as a natural amino acid-based wetting agent. It has a bipolar structure with stable positive and negative charges in the molecule and is called glycine betaine and betaine in addition to trimethylglycine. Trimethylglycine is also known as a betaine-type surfactant.
Trimethylglycine is sold under the trade name of AQUADUO AN-100 from Ajinomoto Co., Ltd. and Amino Coat from Asahi Kasei Chemicals Co., Ltd., and these commercial products can be used.

  The amount of trimethylglycine is 0.1 to 15.0%, preferably 0.5 to 10.0%, more preferably 1.0 to 6.0% of the total composition. If the blending amount is less than 0.1%, the effect of improving taste and the effect of suppressing deterioration of the kneaded skin after low-temperature storage are not sufficiently exhibited. If the amount exceeds 15%, the kneaded skin is deteriorated or the taste of trimethylglycine is generated .

  Furthermore, the mass ratio [(C) / (B)] of (C) trimethylglycine to (B) sodium carboxymethylcellulose is 0.1 to 8.0, preferably 0.3 to 4.0. If the ratio is less than 0.1, the taste after use cannot be improved, and if it exceeds 8.0, the effect of improving the deterioration of kneaded skin over time after low-temperature storage is not sufficiently exhibited, and the taste-inhibiting effect is sufficient. Is not demonstrated.

  The dentifrice composition of the present invention can be blended with other known additives as optional components in addition to the above-mentioned essential components as long as the effects of the present invention are not impaired. Can be prepared. For example, in the case of a toothpaste, abrasives, thickeners (water retention agents), binders, surfactants, sweeteners, preservatives, active ingredients, colorants (pigments), fragrances, etc. can be blended. Can be mixed with water.

  As abrasives, dicalcium phosphate dihydrate, anhydrous dibasic calcium phosphate, calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate , Heavy calcium carbonate, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tricalcium phosphate, hydroxyapatite, fluoroapatite, calcium deficient apatite, tricalcium phosphate, tetracalcium phosphate, eighth calcium phosphate, synthetic resin system Examples thereof include silica-based abrasives such as abrasives, precipitated silica, silica gel, aluminosilicate, and zirconosilicate. Among these abrasives, silica-based abrasives and aluminum hydroxide are preferably used as abrasives from the viewpoint of dextranase stability. Usually, the total amount of these abrasives is about 10 to 50%.

  Further, as cleaning aids, alkali agents such as sodium bicarbonate and sodium carbonate, organic acids such as citric acid, malic acid, tartaric acid, ascorbic acid, lactic acid and acetic acid and salts thereof can be blended.

  As a thickener, one kind of polyhydric alcohols other than pentylene glycol such as sorbit, glycerin, propylene glycol, polyethylene glycol having a molecular weight of 200 to 6000, ethylene glycol, 1,3-butylene glycol, reduced starch saccharified product, etc. Two or more kinds can be combined and blended. The blending amount is usually preferably 5 to 70% with respect to the total amount of the composition.

As the binder, other binders may be added in addition to sodium carboxymethylcellulose. Examples of other binders include inorganic binders such as sodium alginate, propylene glycol alginate, polyvinyl alcohol, hydroxyethyl cellulose, sodium polyacrylate, xanthan gum, carbopol, guar gum, gelatin, avicel, montmorillonite, kaolin and bentonite. Agents and the like.
In addition, other binders may not be blended, but when blended, the total blending amount of the binder ((B) total blending amount of sodium carboxymethylcellulose and other binder) is a composition. 0.1 to 3% of the whole, especially 0.5 to 3% is preferable.

  As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended.

Examples of the anionic surfactant include lauryl sulfate, myristyl sulfate, N-lauroyl sarcosine salt, myristyl sarcosine salt, N-lauroyl taurine salt and the like, and sodium salt and the like can be used. Nonionic surfactants include, for example, alkyl glycosides having an alkyl chain length of 8 to 16 carbon atoms, sucrose fatty acid esters and lactose fatty acid esters having 12 to 18 carbon atoms of fatty acid groups such as sucrose mono and dilaurate. , Lactitol fatty acid ester, maltitol fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, lauroyl diethanolamide and other alkyloyl ethanolamides, polyoxyethylene polyoxypropylene glycol, lauric acid Decaglyceryl and the like can be mentioned. Examples of amphoteric surfactants include betaines other than trimethylglycine such as coconut oil fatty acid amidopropyl betaine, alkyldimethylaminoacetic acid betaine, fatty acid amidopropyl betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine. And surface active agents.
These surfactants can be used alone or in combination of two or more. The blending amount of the optional surfactant is usually 0.1 to 5.0% based on the total amount of the composition.

  Examples of the sweetening agent include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin and the like.

  As a preservative, in addition to pentylene glycol, other known preservatives may be blended. For example, paraoxybenzoates such as butylparaben and ethylparaben, benzoates such as sodium benzoate and nonionic antibacterial agents such as triclosan, and cationic antibacterial agents such as benzethonium chloride, benzalkonium chloride and cetylpyridinium chloride Agents, essential oil components, etc. can be blended. Other preservatives may not be blended, but when blended, an effective amount can be blended within a range that does not hinder the effects of the present invention.

  Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint Natural fragrances, such as absolute rose and orange flower, and fragrances processed by these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), and menthol , Carvone, Anethole, Cineol, Methyl salicylate , Synamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde , Citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, Butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, Single-flavored ingredients such as ethyl thioacetate, and strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The well-known fragrance | flavor raw material used for a thing can be used, It is not limited to the fragrance | flavor of an Example.

  Moreover, although the compounding quantity of a fragrance | flavor is not specifically limited, It is preferable to use said fragrance | flavor raw material 0.000001 to 1% in a formulation composition. Moreover, as a fragrance | flavor for fragrance | flavor using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a formulation composition.

  As colorants, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3 No. is exemplified.

  Various active ingredients include linear water-soluble polyphosphates, alkali metal monofluorophosphates such as sodium monofluorophosphate, fluorides such as sodium fluoride and stannous fluoride, dextranase, amylase, Enzymes such as proteinase, mutanase, tranexamic acid, epsilon-aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, vitamin C, vitamin E and other anti-inflammatory agents, copper chlorophyll, copper gluconate, Fungicides such as cetylpyridinium chloride, benzalkonium chloride, triclosan, hinokitiol, lysozyme chloride, tobacco spider removers such as polyethylene glycol and polyvinylpyrrolidone, and hypersensitivity prediction such as aluminum lactate and potassium nitrate Agents can also be incorporated. In addition, the compounding quantity of an active ingredient can be made into an effective quantity in the range which does not inhibit the effect of this invention.

  Moreover, the material in particular of the container which stores a dentifrice composition is not restrict | limited, Usually, the container used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon, laminate (AL (aluminum) -plastic) containers, metal containers, and the like can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

Examples and comparative examples
Toothpaste compositions having the compositions shown in Tables 1 to 5 were prepared by the following production method.
Method for producing dentifrice composition;
(1) A phase was prepared by mixing and dissolving pentylene glycol, trimethylglycine and water-soluble components (excluding sodium carboxymethylcellulose and propylene glycol) in purified water at room temperature.
(2) A phase B in which sodium carboxymethylcellulose was dispersed in propylene glycol at room temperature was prepared.
(3) B phase was added and mixed in A phase under stirring, and C phase was prepared.
(4) In phase C, ingredients other than water-soluble ingredients such as fragrances, abrasives and anionic surfactants are mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kogakusho), and defoamed under reduced pressure This performed 1.2 kg of a dentifrice composition.
The obtained dentifrice composition (50 g) was mixed with a 26 mm diameter laminated tube (LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / AL10 / EMAA30 / LDPE20 / LLDPE30, thickness 257 μm (large Nippon Printing Co., Ltd.)).

The abbreviations and names in the layer structure of the laminated tube used are as follows, and the numbers following the abbreviations indicate the thickness (μm) of each layer.
LDPE: Low density polyethylene White LDPE: White low density polyethylene LLDPE: Linear low density polyethylene AL: Aluminum PET: Polyethylene terephthalate EMAA: Copolymer resin of ethylene / methacrylic acid

For preparation of these dentifrice compositions, 1,2-pentanediol (manufactured by Tokyo Chemical Industry Co., Ltd.), sodium carboxymethylcellulose (manufactured by Daicel Chemical Industries, Ltd., trade name: CMC1260, DS degree 0) as pentylene glycol .9, 2% aqueous solution viscosity (measured with a B-type viscometer at 20 ° C.): 975 mPa · s), trimethylglycine (manufactured by Ajinomoto Co., Inc., trade name: Aqua Dew AN-100). In addition, the outside standard specifications were used for anhydrous silicic acid, sodium lauryl sulfate, sorbit, propylene glycol, sodium saccharin, and water.
The viscosity of sodium carboxymethylcellulose is a measurement value (20 ° C.) after 3 minutes at 20 rpm using a No. 2 rotor by a B8H viscometer manufactured by Tokyo Keiki Co., Ltd.

  The dentifrice composition was evaluated for (1) off-taste, (2) kneaded skin after low-temperature storage, and (3) shape retention by the following methods. The results are also shown in Tables 1-5.

(1) Evaluation of nasty taste Using 10 subjects, about 1 g of the dentifrice composition of each composition was put on a toothbrush (made by Lion Corporation, Clinica Habrush 4 row head, medium), and the taste of the taste when brushed for 3 minutes. The degree (the degree of unpleasant taste during and after use of the dentifrice) was evaluated by the following three grades using Comparative Example 1 as a control sample. The evaluation results of 10 people were averaged, and the degree of taste was judged according to the following evaluation criteria.

Degree of taste (rating);
3 points: The degree of taste is weak compared to the control sample 2 points: The degree of taste is slightly weaker than the control sample 1 point: Evaluation standard having the same or strong taste of taste compared to the control sample;
◎: 2.5 points or more and 3.0 points or less ○: 2.0 points or more and less than 2.5 points △: 1.5 points or more and less than 2.0 points ×: Less than 1.5 points

(2) Evaluation of kneaded skin after low temperature storage The dentifrice composition of each composition was filled in the above laminated tube having a diameter of 8 mm, stored in a 5 ° C constant temperature bath for 4 weeks, and then the appearance of kneading when extruded from the tube (surface And wrinkles and gloss) were compared with those stored at room temperature and evaluated.

Evaluation criteria;
◎: There is no wrinkle on the surface and the surface is glossy ○: There is no wrinkle on the surface, but the gloss is slightly deteriorated △: Slight wrinkles are observed on the surface, and the gloss is inferior ×: Wrinkles are recognized on the surface and gloss There is no

(3) Evaluation of shape retention Dentifrice on a toothbrush when 10 subjects were used and about 1 g of the dentifrice composition of each composition was placed on a toothbrush (manufactured by Lion Corporation, Clinica Habrush 4 row head, medium). The shape and the presence or absence of dripping were evaluated according to the following criteria. The evaluation results of 10 people were averaged, and the degree of shape retention was judged according to the following evaluation criteria.

Degree of shape retention (score);
3 points: The paste shape hangs on the toothbrush and does not sag from the toothbrush.
2 points: The paste shape on the toothbrush is slightly broken, but does not sag from the toothbrush.
1 point: The shape of the paste collapses on the toothbrush and hangs down from the toothbrush.
(Evaluation criteria)
◎: 2.5 points or more and 3.0 points or less ○: 2.0 points or more and less than 2.5 points Δ: 1.5 points or more and less than 2.0 points ×: Less than 1.5 points

  From the results of Tables 1 to 5, when (A) the dentifrice composition containing pentylene glycol is blended with sodium carboxymethylcellulose (B) or trimethylglycine (C), or (B) and ( Even if the component (C) is blended, if the blending amount or blending ratio of each component is inappropriate, a nasty taste is produced, and the pentylene of the present invention is inferior to the kneaded skin and the shape retention after low-temperature storage. It was confirmed that the dentifrice composition containing glycol is excellent in feeling of use, has a good feeling during use and after use of the dentifrice, has good shape retention, and is excellent in low-temperature storage stability of kneaded skin. .

Claims (1)

  (A) A dentifrice composition containing pentylene glycol is blended with 0.1 to 2.0% by mass of (B) sodium carboxymethylcellulose and (C) 0.1 to 15% by mass of trimethylglycine. The dentifrice composition, wherein (C) / (B) is 0.1 to 8.0 in terms of mass ratio.