JP5948903B2 - Dentifrice composition and method for improving antiseptic power of dentifrice composition - Google Patents

Description

  The present invention is a dentifrice composition having a high antiseptic power, more specifically, a high antiseptic power of the preparation, and excellent storage stability, and also has a high dispersibility in the oral cavity without taste. It is related with the dentifrice composition excellent in the usability | use_condition, and the preservative improvement method of a dentifrice composition.

  One of the important means for preventing the development of caries is brushing behavior at home, and correct brushing is very important to maximize the effect. However, children in the deciduous period, particularly susceptible to dental caries, have difficulty in brushing properly, and thus require a finish brushing by parents. Usually, the finish polishing is performed by the guardian while checking the condition of the child's oral cavity. However, when finishing polishing is performed using a commercially available dentifrice, the oral cavity becomes difficult to see due to its foaming properties, and plaque etc. It was difficult to determine whether the dirt was removed. In addition, there was a problem that it was impossible to brush the teeth properly because the children hated the bubbles themselves and the bubbles dropped.

  On the other hand, in order to avoid these problems, there are many cases where brushing is done only with a toothbrush without using a dentifrice. In this case, the original purpose of toothbrushing is caries prevention and plaque removal effect. From the point of view, it was insufficient.

  As means for solving these problems, dentifrices with a small amount of anionic surfactant and less foaming are on the market. However, in this case, the taste of the preparation was poor, and it was insufficient for finishing for a long time in terms of palatability. Moreover, there existed a subject that the antiseptic power fall of a formulation and the fall of stability will arise by reducing an anionic surfactant.

  In addition, in order to improve the taste of the preparation, there is a method of masking the unpleasant taste by adding a sweetener such as saccharin sodium, but in this case, the taste of the sweetener is emphasized too much and the unpleasant taste can be necessarily suppressed. I couldn't say that.

  As a method for enhancing the antiseptic power of the dentifrice composition and preventing contamination of the preparation, it is common to add a preservative. As preservatives, paraoxybenzoic acid esters such as ethyl paraoxybenzoate, methyl paraoxybenzoate, and butyl paraoxybenzoate, sodium benzoate, potassium sorbate, sodium dehydroacetate, and the like are known. However, when a preservative is blended, there is a problem that the taste during use deteriorates and the feeling of use is inferior.

  As a technique that does not contain a preservative such as paraoxybenzoic acid ester and ensures a sufficient antiseptic power, a method using titanium oxide and a cationic fungicide in combination (Patent Document 1; JP 2010-37293 A) or a specific method A method using a perfume (Patent Document 2; JP 2001-302475 A) is known. However, even if these methods are employed, it has been difficult to ensure sufficient antiseptic power with the dentifrice composition. In particular, it was difficult to satisfactorily ensure antiseptic power even with a dentifrice composition having a small amount of anionic surfactant.

  On the other hand, glycerin is generally blended as a wetting agent for the purpose of preventing the dentifrice composition from drying and maintaining a good appearance and improving the usability by imparting an appropriate viscosity to the preparation (Patent Literature). 3; Japanese Patent No. 3959636, Patent Document 4; Japanese Patent Application Laid-Open No. 2001-72559, Japanese Patent Application Laid-Open No. 2002-234826, Japanese Patent Application Laid-Open No. 2005-200327; By increasing the amount of glycerin, the amount of water in the preparation can be reduced and the preservative power can be increased. However, due to its high viscosity, the spinnability of the preparation increases and the dispersibility decreases depending on the amount added. Therefore, there was a problem that the feeling of use deteriorated.

JP 2010-37293 A JP 2001-302475 A Japanese Patent No. 3959636 JP 2001-72559 A JP 2002-234826 A JP 2005-200327 A

  As described above, in a dentifrice composition, particularly in a dentifrice composition with less foaming that can be suitably used for brushing teeth over time such as finishing brushing, high antiseptic power is ensured and the storage stability of the preparation is maintained. It was difficult to satisfy both the performance and the feeling of use. Therefore, a new technique that can sufficiently secure a high antiseptic power in a dentifrice composition while sufficiently maintaining the storage stability and usability of the preparation is desired.

  The present invention has been made in view of the above circumstances, and an object thereof is to provide a dentifrice composition and a method for improving the antiseptic power of a dentifrice composition, which can ensure high antiseptic power and have good storage stability and usability. And

As a result of intensive studies to achieve the above object, the inventors of the present invention have developed a dentifrice composition containing no preservative selected from paraoxybenzoic acid ester and sodium benzoate, and (A) a polyglycerin fatty acid ester and ( B) By adding a chelating agent, (C) xylitol and / or erythritol, and (D) glycerin, the antiseptic power of the dentifrice composition can be unexpectedly secured sufficiently, and the storage stability of the preparation Was found to be good and free from disgust, good dispersibility in the oral cavity, and excellent usability, and led to the present invention.

  In the present invention, the polyglycerin fatty acid ester and chelating agent are used in combination, and xylitol and / or erythritol and glycerin are blended, so that the mechanism of action is not clear, but it exhibits high antiseptic power and The storage stability is enhanced, and further, the occurrence of an unpleasant taste derived from the blended components can be suppressed, the dispersibility in the oral cavity is improved, and a good feeling in use can be secured. Therefore, in the present invention, by blending the components (A), (B), (C) and (D), various conventional problems are solved, high antiseptic power is ensured, and the storage stability of the preparation is increased. The compatibility and feeling of use can also be satisfied. According to the present invention, a high antiseptic power can be ensured even in a composition having a small content of an anionic surfactant and a small amount of foaming, or even when a preservative such as paraoxybenzoic acid ester is not blended. Can maintain good storage stability and usability. Therefore, it is also possible to provide a low-foaming preparation suitable for brushing teeth over time such as finishing polishing for children in the deciduous period.

Therefore, the present invention provides the following dentifrice composition and a method for improving the antiseptic power of the dentifrice composition.
[I]
A dentifrice composition containing no preservative selected from paraoxybenzoic acid ester and sodium benzoate,
(A) 0.05 to 3% by mass of a polyglycerol fatty acid ester selected from decaglyceryl laurate and decaglyceryl oleate,
(B) a chelating agent selected from citric acid, DL-malic acid, polyphosphoric acid and salts thereof
0.001 to 3 mass%,
(C) 3 to 15% by mass of xylitol and / or erythritol, and (D) 3 to 30% by mass of glycerin
A dentifrice composition characterized by comprising.
[II]
To a dentifrice composition containing no preservative selected from paraoxybenzoate ester and sodium benzoate,
(A) 0.05 to 3% by mass of a polyglycerol fatty acid ester selected from decaglyceryl laurate and decaglyceryl oleate,
(B) a chelating agent selected from citric acid, DL-malic acid, polyphosphoric acid and salts thereof
0.001 to 3 mass%,
(C) 3 to 15% by mass of xylitol and / or erythritol, and (D) 3 to 30% by mass of glycerin
A method for improving the antiseptic power of the dentifrice composition, characterized by comprising :

  According to the present invention, the antiseptic power of the dentifrice composition can be sufficiently secured, and the storage stability of the preparation is good, the taste is not bad, the dispersibility in the oral cavity is good, and the usability is excellent. A formulation can be provided. In the present invention, it is possible to ensure excellent antiseptic power while maintaining good storage stability and feeling of use, even if there is little foaming, or even without adding a preservative, It is also possible to provide a preparation having a low foaming property and good safety, which is suitable for brushing teeth over time such as finish polishing.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention comprises (A) polyglycerin fatty acid ester, (B) chelating agent, (C) xylitol and / or erythritol, and (D) glycerin.

  As the (A) polyglycerin fatty acid ester used in the present invention, polyglycerin in which 2 to 20 glycerin is condensed and 1 to 4 fatty acids having 8 to 24 carbon atoms are ester-bonded can be used. Decaglyceryl laurate, which is a monoester of polyglycerin and a fatty acid having 12 carbon atoms, is more preferred from the viewpoint of high antiseptic power and good taste.

(A) A commercial item can be used for polyglycerol fatty acid ester. For example, as decaglyceryl laurate, a product manufactured by Nikko Chemicals Co., Ltd. or a product manufactured by Sakamoto Pharmaceutical Co., Ltd. can be used.

  (A) The compounding quantity of polyglyceryl fatty acid ester is 0.05 to 3% (mass%, the following is similar) of the whole composition, and 0.1 to 1% is especially suitable. If it is less than 0.05%, sufficient antiseptic power may not be exhibited, and if it exceeds 3%, an unpleasant taste may occur and the taste may be deteriorated, and foam may be excessively formed.

  (B) The chelating agent is not particularly limited as long as it has chelating ability, and examples thereof include condensed phosphoric acid such as EDTA, citric acid, phytic acid, polyphosphoric acid, DL-malic acid, gluconic acid, and salts thereof. Can be mentioned. Examples of the salt include alkali metal salts such as sodium salt. Of these, citric acid and its salts are most preferred from the viewpoints of excellent taste and ease of use, and high antiseptic power and storage stability.

(B) A commercially available product can be used as the chelating agent. For example, citric acid and sodium citrate can both be products manufactured by Komatsuya Co., Ltd.

  (B) The compounding quantity of a chelating agent is 0.001-3% of the whole composition, and 0.01-1.5% is especially suitable. If it is less than 0.001%, sufficient preservative power may not be exhibited, and if it exceeds 3%, taste may be bad and the taste may be deteriorated.

  (C) A commercially available product can be used as xylitol. For example, products manufactured by Rocket Japan Co., Ltd. can be used. A commercially available product can also be used for erythritol, for example, a product of Mitsubishi Chemical Foods Co., Ltd. can be used.

  (C) The compounding amount of xylitol and / or erythritol is preferably 3 to 15%, particularly 5 to 12% of the whole composition. If it is less than 3%, sufficient antiseptic power is not exhibited and the feeling of use may be deteriorated, and if it exceeds 15%, the stability of the preparation may be deteriorated.

  (D) If glycerol is normally used for a dentifrice composition, there will be no restriction | limiting in particular. Specifically, commercially available products such as glycerin (85% glycerin) manufactured by Lion Chemical Co., Ltd. can be used.

  The blending amount of glycerin is preferably 3 to 30%, particularly 10 to 25% of the whole composition. If it is less than 3%, sufficient antiseptic power may not be exhibited, and if it exceeds 30%, the taste becomes worse, and stickiness increases and the dispersibility decreases, resulting in poor usability.

  In the present invention, the blending ratio ((C) / (D)) of xylitol and / or erythritol as the component (C) and glycerin as the component (D) is 0.2-5, particularly 0.3- 3 is preferable from the viewpoints of antiseptic power, formulation stability, good taste, and good dispersibility.

  The dentifrice composition of the present invention can be prepared into dentifrices of various shapes such as toothpaste, liquid dentifrice, liquid dentifrice, and moisturized dentifrice, and can also be prepared as a gel dentifrice. In this case, a known additive other than the components (A) to (D) can be blended as an optional component in addition to the essential components as long as the effect of the present invention is not impaired depending on the dosage form. For example, abrasives, thickeners, binders, surfactants, sweeteners, preservatives, active ingredients, fragrances, colorants and the like can be blended, and these ingredients can be mixed with water for production.

  As abrasives, silica-based abrasives such as silica gel, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate or anhydrous, tricalcium phosphate, quaternary calcium phosphate, eighth calcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate Phosphoric acid type abrasives such as aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tertiary magnesium phosphate , Zeolite, zirconium silicate, hydroxyapatite, fluoroapatite, calcium deficient apatite, synthetic resin-based abrasive, and the like, and one or more are used. The amount is usually 0 to 50%, particularly 0 to 30%, based on the total amount of the composition.

  Examples of the wetting agent include known wetting agents other than xylitol, erythritol, and glycerin, for example, sugar alcohols such as sorbitol and reduced starch saccharified products, polyhydric alcohols such as polyethylene glycol, propylene glycol, ethylene glycol, and 1,3-butylene glycol. 1 type or 2 types or more can be mix | blended. These wetting agents do not need to be blended, and the blending amount can be 0 to 35% of the total composition as long as the effects of the present invention are not hindered.

  As binder, cellulose binder such as sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylethylcellulose, methylcellulose, xanthan gum, carrageenan, guar gum, sodium alginate, cationized cellulose, montmorillonite, gelatin And sodium polyacrylate, and the like, and one or more of them can be blended. A compounding quantity is 0.1 to 5% normally with respect to the composition whole quantity.

As the surfactant, an anionic surfactant usually used in a dentifrice composition, a nonionic surfactant other than the polyglycerin fatty acid ester of the component (A), an amphoteric surfactant, and the like can be blended.
Anionic surfactants include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, acyl sarcosine salts such as sodium lauroyl sarcosine and sodium myristoyl sarcosine, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, lauryl sulfo Examples thereof include N-acyl glutamate such as sodium acetate and sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate, and the like. The blending amount of the anionic surfactant may be reduced to suppress foaming of the preparation. The blending amount of the anionic surfactant is 1% or less, particularly 0 to 0.5%, particularly 0 to 0.1%. can do.

Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, and alkyl glucoside.
Examples of amphoteric surfactants include lauryl dimethylaminoacetic acid betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, and coconut oil fatty acid amidopropyl. Although betaine etc. are used, it is not restricted to the above.
The blending amount of these surfactants may be in a range that does not hinder the effects of the present invention, and is usually 0 to 10% of the whole composition, and particularly 0.1 to 5% including component (A). Is preferred.

Examples of the sweetening agent include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin and the like.
Examples of the preservative include paraoxybenzoic acid esters such as butylparaben and ethylparaben, sodium benzoate, and the like. Such a known preservative does not have to be blended, and when blended, it is preferably 1% or less, particularly 0 to 0.5% within a range that does not hinder the effects of the present invention.

  Examples of various active ingredients include fluorine compounds such as sodium fluoride, sodium monofluorophosphate and tin fluoride, enzymes such as dextranase and mutanase, and water-soluble phosphate compounds such as potassium phosphate and sodium salt of orthophosphate. , Isopropylmethylphenol, tranexamic acid, epsilon-aminocaproic acid, allantoinchlorohydroxyaluminum, hinokitiol, sodium lauroyl sarcosine, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, glycyrrhetin, glycyrrhetic acid, copper Phosphate compounds such as sodium chlorophyllin, chlorophyll, glycerophosphate, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, Potassium acetate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, cetylpyridinium chloride, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide In addition, extracts such as zinc citrate, soft sugar beet extract, buckwheat extract, chamomile, clove, rosemary, hornon, safflower and the like can be blended. In addition, the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.

  Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint Natural fragrances such as absolute rose and orange flower, and fragrances processed by these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), menthol, Carvone, Anethole, Cineol, Methyl salicylate, C Namic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, citral , Pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, Isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl Toothpaste compositions such as single flavors such as thioacetate, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The well-known perfume material used for can be used, and it is not limited to the perfume of an Example.

  Examples of the colorant include Blue No. 1, Yellow No. 4, Green No. 3, and the like. In addition, the compounding quantity of these components can be made into a normal quantity in the range which does not prevent the effect of this invention.

  Usually, water is used as the solvent. Further, a lower monohydric alcohol such as ethanol may be added, but the blending amount is preferably 0 to 5%.

  The material in particular of the container which accommodates the dentifrice composition of this invention is not restrict | limited, Usually, the container used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% is mass% unless otherwise specified.

Examples and comparative examples
Dentifrice compositions (gel dentifrices) having the compositions shown in Tables 1 to 3 were prepared by the following production method.
Manufacturing method:
(1) A phase was prepared by mixing and dissolving water-soluble components (excluding binder and propylene glycol) in purified water at room temperature.
(2) A phase B in which a binder was dispersed at room temperature in propylene glycol was prepared.
(3) B phase was added and mixed in A phase under stirring, and C phase was prepared.
(4) In phase C, ingredients other than water-soluble ingredients such as fragrances are mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kogakusho), defoamed under reduced pressure (4 kPa), and dentifrice composition 1 .2 kg was obtained.

  To prepare the dentifrice composition, decaglyceryl laurate (manufactured by Sakamoto Pharmaceutical Co., Ltd.), decaglyceryl oleate (manufactured by Sakamoto Pharmaceutical Co., Ltd.), citric acid (manufactured by Komatsuya Co., Ltd.), Sodium citrate (manufactured by Komatsuya Co., Ltd.), DL-malic acid (manufactured by Fuso Chemical Industry Co., Ltd.), sodium polyphosphate (manufactured by Taihei Chemical Industrial Co., Ltd.), xylitol (manufactured by Rocket Japan Co., Ltd.), erythritol (Mitsubishi Chemical Foods Co., Ltd.) and glycerin (Lion Chemical Co., Ltd., 85% glycerin) were used.

The prepared dentifrice composition is a laminated tube (LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / AL10 / EMAA30 / LDPE20 / LLDPE30, thickness 257 μm (Dai Nippon Printing Co., Ltd.) whose innermost layer is made of linear low density polyethylene. 50 g) was filled.
The abbreviations and names in the layer structure of the laminated tube used are as follows, and the numbers following the abbreviations indicate the thickness (μm) of each layer.
LDPE: Low density polyethylene white LDPE: White low density polyethylene LLDPE: Linear low density polyethylene AL: Aluminum PET: Polyethylene terephthalate EMAA: Ethylene / methacrylic acid copolymer resin

  About the obtained dentifrice composition, the antiseptic power of the formulation, stability, tastelessness, and dispersibility were evaluated by the following methods. The results are shown in Tables 1-3.

(1) Evaluation method of antiseptic power of dentifrice formulation Inoculate test strain (bacteria and fungi derived from the environment) into 30 g of dentifrice composition so as to be about 10 ⁷ CFU / g. The number of bacteria after 30 days was measured and evaluated according to the following criteria.
Evaluation standard of antiseptic power ◎: Bacteria die within 7 days ○: Bacteria die within 8-20 days △: Bacteria die over 21-30 days ×: Bacteria do not die over 31 days

(2) Method for evaluating the stability of the formulation The prepared dentifrice composition was stored for 1 month under the condition of 40 ° C., and the appearance stability was evaluated according to the following criteria.
Stability Evaluation Criteria A: A glossy and uniform paste.
A: A uniform paste with a slight gloss.
Δ: A uniform paste with no gloss.
X: It was a non-uniform paste form.

(3) Evaluation method of tastelessness A sensory test was conducted using 10 expert panelists. About 0.5 g of the dentifrice composition was placed on a commercially available toothbrush and brushed for 3 minutes, and the tasteless taste felt during use was sensory evaluated according to the following rating. An average value of the evaluation results of 10 persons was obtained, and those for which evaluations of ◎ and ◯ were ensured based on the following criteria were judged to be dentifrice compositions without taste.
Evaluation criteria for lack of taste 4 points: No disgust 3 points: Little dislike 2 points: Some dislike 1 point: Disgust Appraisal criteria ◎: 3.5 points to 4.0 points ○: 3.0 points to less than 3.5 points Δ: 2.0 points to less than 3.0 points ×: less than 2.0 points

(4) Evaluation method of good dispersibility during use The evaluation was performed by a sensory test using 10 expert panelists. About 1 g of the dentifrice composition was placed on a commercial toothbrush and brushed for 3 minutes, and the good dispersibility of the preparation in use in the oral cavity was evaluated according to the following rating. The average score of 10 people was evaluated according to the following criteria and indicated in the table with ◎, ○, Δ, and ×.
Evaluation criteria for good dispersibility of the preparation in the oral cavity 4 points: Dispersibility is very good 3 points: Dispersibility is quite good 2 points: Dispersibility is slightly good 1 point: Dispersibility is not good Evaluation criteria A: 3.0 points to 4.0 points ○: 2.0 points to less than 3.0 points Δ: 1.5 points to less than 2.0 points ×: less than 1.5 points

Claims (7)

A dentifrice composition containing no preservative selected from paraoxybenzoic acid ester and sodium benzoate,
(A) 0.05 to 3% by mass of a polyglycerol fatty acid ester selected from decaglyceryl laurate and decaglyceryl oleate,
(B) a chelating agent selected from citric acid, DL-malic acid, polyphosphoric acid and salts thereof
0.001 to 3 mass%,
(C) 3 to 15% by mass of xylitol and / or erythritol, and (D) 3 to 30% by mass of glycerin
A dentifrice composition characterized by comprising.   (B) The dentifrice composition according to claim 1, wherein the chelating agent is citric acid or a salt thereof.   The dentifrice composition according to claim 1 or 2, wherein the mass ratio of component (C) / component (D) is 0.2-5.   The dentifrice composition of any one of Claims 1-3 whose compounding quantity of an anionic surfactant is 0-1 mass%. To a dentifrice composition containing no preservative selected from paraoxybenzoate ester and sodium benzoate,
(A) 0.05 to 3% by mass of a polyglycerol fatty acid ester selected from decaglyceryl laurate and decaglyceryl oleate,
(B) a chelating agent selected from citric acid, DL-malic acid, polyphosphoric acid and salts thereof
0.001 to 3 mass%,
(C) 3 to 15% by mass of xylitol and / or erythritol, and (D) 3 to 30% by mass of glycerin
A method for improving the antiseptic power of the dentifrice composition, characterized by comprising : Component (C) / (D) antiseptic improved method of claim 5 dentifrice composition according to mass ratio of the component is 0.2 to 5. The method for improving the antiseptic power of a dentifrice composition according to claim 5 or 6, wherein the amount of the anionic surfactant is 0 to 1% by mass.