JP2002003302A - Microjet aerosol composition and method for jetting the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a microjet aerosol composition capable of maintaining the aerial concentration of an active ingredient for a long period and maintaining the effect of the active ingredient for a long period even when jetted in a small amount of the active ingredient such as an insecticide. SOLUTION: This aerosol composition is filled in a jetting device jetting a small amount of an active ingredient at a high concentration and is characterized by using a low-boiling solvent as the solvent for the active ingredient. The method for jetting is characterized by comprising jetting 0.1-0.3 ml above microjet aerosol composition per one jet.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention provides a micro-aerosol composition and a method for spraying the same.

[0002]

2. Description of the Related Art Conventionally, as an insect repellent for pests such as mosquitoes in a room, various types such as an aerosol composition, a mosquito coil and an electric mosquito coil have been known. In general, an aerosol composition is quick-acting but not persistent, and mosquito coils, electric mosquito traps and the like are persistent but have no immediate effect.
Therefore, it is very useful and convenient if an aerosol composition can achieve both quick-acting and long-lasting effects. Attempts have been made to solve the above-mentioned problems by spraying the active ingredient at a high concentration, but an aerosol composition having a long-lasting effect has not been obtained.

[0003]

DISCLOSURE OF THE INVENTION The present invention provides a micro-aerosol composition capable of maintaining the air concentration of an active ingredient for a long time even when a small amount of an active ingredient such as an insecticide is sprayed, and maintaining the effect of the active ingredient for a long time. It is an object to provide an object and a method for spraying the same.

[0004]

Means for Solving the Problems As a result of studying to solve the above problems, the present inventor has found that the use of a solvent having a low boiling point makes it easier for the active ingredient to stay in the air.
The inventors have found that the effect is long-lasting, and have completed the present invention. That is, the present invention relates to an aerosol composition to be filled in a spraying device that sprays a small amount of an active ingredient at a high concentration, and a small-injection aerosol composition characterized in that the solvent of the active ingredient is a low-boiling solvent. Related. Further, the present invention provides the above-mentioned micro-injection aerosol composition at a time of 0.1%.
The present invention relates to a spraying method characterized in that a jet is performed at 0.3 ml.

[0005] In the present invention, the active ingredient of the micro-injection aerosol composition should not be particularly limited,
Insecticides, insect repellents, fragrances, deodorants and the like can be mentioned. As the active ingredient, an insecticide is preferable, and as the insecticide, transfluthrin, d, dt-80-praletrin, resmethrin, phthalthrine, phenothrin, dl, dt.
-80-aresulin, d, dt-100-aresulin,
Pyrethroid compounds such as etofenprox,
DDVP, fenthion, fenitrothion, temefos, phoxime, acephate, pyridafenthion, diazinon, etrimphos, malathion, prothiophos, propetanphos, pyraclophos, chlorpyrifos,
Organophosphorus pesticides such as chlorpyrifosmethyl, NA
Examples thereof include carbamate insecticides such as C, bendiocarb and propoxur, and those known in the literature such as chemical abstracts.

Other active ingredients include chitin synthesis inhibitors such as diflubenzuron and buprofezin, juvenile hormone-like substances such as pyriproxyfen, octachlorodipropyl ether, isobornyl thiocyanoacetate, piperonyl butoxide, N- (2-ethylhexyl) -bicyclo- [2,2,1] -hepta-5-ene-
2,3-dicarboximide, N- (2-ethylhexyl) -1-isopropyl-4-methylbicyclo- [2,
Synergists such as 2,2] -oct-5-ene-2,3-dicarboximide; and attractants such as lauric acid, d-limonene, orange oil and mixtures thereof.

[0007] The vapor pressure of these active ingredients is 10 ^-4 P
a order is preferable, and for example, transfluthrin is exemplified. Here, the order of 10 ⁻⁴ Pa refers to a range of 1 × 10 ^{−4 to} 9 × 10 ⁻⁴ Pa.

In the composition of the present invention, the above-mentioned active ingredient is dissolved in a low-boiling solvent capable of dissolving the active ingredient. In the present invention, a low-boiling solvent refers to a solvent having a boiling point of 100 ° C. or lower. Examples of the low-boiling solvent include alkanes having 5 to 6 carbon atoms or a halogen-substituted product thereof, such as isopentane, isohexane, hexane, and perfluorocarbon.
Used alone or in combination.

In the present invention, the injection device for injecting a small amount of the active ingredient at a high concentration is not particularly limited as long as it has means capable of quantitatively injecting a small amount of the composition of the present invention containing the active ingredient at a high concentration. Although not required, a spraying device which is preferably installed in a room and sprayed, and which incorporates a system for regularly spraying a higher concentration of an active ingredient than an ordinary space aerosol may be used.

The micro-aerosol composition of the present invention comprises an active ingredient, a low-boiling solvent and a propellant, an inorganic powder such as a silica powder, a preservative such as dibutylhydroxytoluene and the like. The propellant is charged into the above-described injection device containing other components by a known gas charging method or the like. As a propellant, room temperature,
It is preferably a gaseous one at normal pressure and liquefied in the injector by receiving pressure, and examples thereof include hydrocarbons such as propane and butane, and ethers such as dimethyl ether.

In the microinjection aerosol composition of the present invention, a high concentration of the active ingredient means a range of 0.5 to 5 parts by mass with respect to 100 parts by mass of the composition. Depending on the type of solvent used, there is one
It suffices that the amount of the active ingredient in the composition per unit time be the minimum necessary for injecting into the air, which means about 0.3 ml. The injection may be manual or automatic, and in the case of automatic, includes intermittent injection. The low boiling point solvent is appropriately selected usually from the range of 10 to 70 parts by mass based on 100 parts by mass of the composition according to the properties of the active ingredient and the like. If necessary, a surfactant may be used together with a low-boiling solvent in an amount of usually 1 to 10 parts by mass relative to 100 parts by mass of the composition. Examples of the surfactant include a nonionic surfactant such as a polyoxyethylene alkyl ether compound or a sorbitan fatty acid ester compound.

The spraying method of the present invention sprays the above-mentioned micro-aerosol composition at a rate of 0.1 to 0.3 ml per time, and the effect can be maintained throughout the day only by spraying several times a day. it can. In the case of 6 tatami mats, the injection amount is 0.
Four injections at 2 ml are indications of daily usage. Here, the injection amount refers to the volume of the aerosol composition that can be injected in the injection device, and includes the fine particle solid when the composition includes the solid.

[0013] Since the ejected matter ejected from the micro-injection device to which the present invention is applied is in the form of a micro mist, it spreads to every corner of the space and stays in the air for a long time, so that the effect of the active ingredient is maintained. . Further, the number of injections can be set according to the size of the space. Further, a manual spray type as a micro spray apparatus to which the present invention is applied is easy to carry and does not require a power source, so that it is suitable not only for indoors but also for outdoors. The micro-injection device to which the composition of the present invention and the spraying method of the present invention are applied can be obtained by adjusting the internal pressure with a valve, a tube, an actuator or the like for a fixed-quantity injection.

Since the present invention has the above-described structure, when an insecticide is selected as an active ingredient, it is possible to stay indoors immediately after the injection, and to provide an excellent knockdown effect immediately after the injection for 3 hours or more. Demonstrate.

[0015]

The present invention will be specifically described below with reference to examples. However, the present invention is not limited to only these examples.

Example 1 Transfluthrin (hereinafter referred to as NAK) 327 mg as an active ingredient, isopentane (boiling point: 27.8 ° C.)
5 g, propellant LPG (pressure at 25 ° C. 5.0 kg / c
m ² (490 kPa)) A small amount of aerosol composition consisting of 9.3 g was placed in a spray device equipped with a metering valve capable of spraying 0.2 ml in a fixed amount and prepared. Example 2 In Example 1, d, instead of NAK was used as the active ingredient.
A micro-aerosol aerosol composition was prepared in the same manner as in Example 1 except that 336 mg of dt-80-praletrin (hereinafter referred to as Etoc) was used.

Comparative Example 1 A micro spray aerosol composition was prepared in the same manner as in Example 1, except that neothiozole (paraffin-based mixed solvent, initial boiling point: 226 ° C.) was used instead of isopentane. Comparative Example 2 A micro-injection aerosol composition was prepared in the same manner as in Example 2, except that neothiozole was used instead of isopentane. The performance of each composition contained in the injection device provided with the above-mentioned 0.2 ml fixed amount injection valve equipped with a fixed amount valve was evaluated as follows.

Test Example 1 Adults of Culex pipiens pallens were placed in a gauge of 15 heads and placed at a height of 150 cm and 75 cm in a 6-tatami room. The installation position is
There were two places at each height, for a total of four places (the gauge was installed in the middle between the center and the corner of the room). After hanging the gauge, 0.2 ml of the composition was sprayed four times using a spraying device (10 mg of the active ingredient in 0.8 ml), and the number of knockdowns over time was observed. After 3 hours and 6 hours, the cage was hung at the same position, the number of knockdowns was observed in the same manner, and evaluation was performed using KT90. KT90 indicates the time (minute) when the number of knockdowns is 90% or more of the total number of animals.
The test conditions were room temperature 27 ° C. to 30 ° C., and the ventilation rate per hour was 0.8 to 1.4 times, and the efficacy was evaluated. Table 1 shows the results.

[0019]

[Table 1]

From Table 1, it can be seen that the composition of the present invention is superior in persistence of the effect as compared with the comparative example. Also, NA
It was found that K was superior to Etoc.

Test Example 2 Each composition of Examples 1 and 2 and Comparative Examples 1 and 2 0.8
of the active ingredient in air and the amount of adhering to the floor or wall were measured, and the relationship between the vapor pressure of the active ingredient and the boiling point of the solvent was measured. Considered. The results are shown in Table 2. Air concentration is about 1 for 2 hours
The room air was sucked in at a rate of 3 liters / minute, collected on silica gel and a wrap, and analyzed. The amount of adhesion was measured by putting a filter paper on the floor and the wall in advance, extracting the filter paper with acetone after 8 hours, and using gas chromatography.

[0022]

[Table 2]

From the results in Table 2, the following was found. From a comparison between Example 1 and Comparative Example 1, the formulation using isopentane has a longer sustained concentration in the air. In Example 1, the active ingredient adhered to the floor and the wall, whereas in Comparative Example 1, the active ingredient adhered to the floor, but did not adhere to the wall. Comparing Example 1 and Example 2, NAK has a longer duration of air concentration. In addition, both active ingredients adhered to the floor and walls. By combining an active ingredient having a vapor pressure of the order of 10 ^-4 Pa, such as NAK, and a low-boiling solvent, such as isopentane, the active ingredient easily stays in the air, and the effect lasts longer. Combining an active ingredient with a vapor pressure on the order of 10 ^-4 Pa, such as NAK, and a low-boiling solvent, such as isopentane, causes the active ingredient to adhere to the floor and wall surfaces. It was thought that it volatilized and the air concentration was kept high. A combination of an active ingredient having a vapor pressure of the order of 10 ⁻⁴ Pa and a low-boiling solvent can prepare a micro-injection aerosol composition having a higher concentration in the air and maintaining the same for a long time.

[0024]

Aerosol composition of the present invention exhibits, even a high concentration effective ingredient by using a low-boiling solvent is injected in trace amounts, and prolonged effect of the active ingredient for a long time, ^10-4 as further active ingredient The effect can be further increased by using together with a material having a vapor pressure of Pa order.

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Claims (4)

[Claims] 1. An aerosol composition to be filled in an injection device for injecting a small amount of an active ingredient at a high concentration, wherein the solvent of the active ingredient is a low-boiling solvent. 2. The aerosol composition according to claim 1, wherein the low-boiling solvent is at least one selected from the group consisting of isopentane, isohexane, hexane and perfluorocarbon. 3. The micro-aerosol composition according to claim 1, wherein the active ingredient is an insecticide and the vapor pressure is in the order of 10 ⁻⁴ Pa. 4. A spraying method comprising spraying the micro-aerosol composition according to any one of claims 1 to 3 at a time of 0.1 to 0.3 ml.