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ITMI20042007A1 - "modulatori del ricettore gpr17 e loro impieghi terapeutici" - Google Patents

"modulatori del ricettore gpr17 e loro impieghi terapeutici"

Info

Publication number
ITMI20042007A1
ITMI20042007A1 IT002007A ITMI20042007A ITMI20042007A1 IT MI20042007 A1 ITMI20042007 A1 IT MI20042007A1 IT 002007 A IT002007 A IT 002007A IT MI20042007 A ITMI20042007 A IT MI20042007A IT MI20042007 A1 ITMI20042007 A1 IT MI20042007A1
Authority
IT
Italy
Prior art keywords
gpr17
recipe
modulators
therapeutic uses
therapeutic
Prior art date
Application number
IT002007A
Other languages
English (en)
Inventor
Maria Pia Abbracchio
Paolo Ciana
Claudia Martini
Gianenrico Rovati
Maria Letizia Trincavelli
Claudia Verderio
Original Assignee
Consiglio Nazionale Ricerche
Univ Degli Studi Milano
Univ Pisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale Ricerche, Univ Degli Studi Milano, Univ Pisa filed Critical Consiglio Nazionale Ricerche
Priority to IT002007A priority Critical patent/ITMI20042007A1/it
Publication of ITMI20042007A1 publication Critical patent/ITMI20042007A1/it
Priority to EP05795031A priority patent/EP1807701A2/en
Priority to JP2007537181A priority patent/JP2008516617A/ja
Priority to PCT/EP2005/011157 priority patent/WO2006045476A2/en
Priority to US11/665,835 priority patent/US8158593B2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Neurology (AREA)
IT002007A 2004-10-21 2004-10-21 "modulatori del ricettore gpr17 e loro impieghi terapeutici" ITMI20042007A1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT002007A ITMI20042007A1 (it) 2004-10-21 2004-10-21 "modulatori del ricettore gpr17 e loro impieghi terapeutici"
EP05795031A EP1807701A2 (en) 2004-10-21 2005-10-17 Gpr17 modulators, method of screening and uses thereof
JP2007537181A JP2008516617A (ja) 2004-10-21 2005-10-17 Gpr17調節因子、そのスクリーニング方法、およびその使用
PCT/EP2005/011157 WO2006045476A2 (en) 2004-10-21 2005-10-17 Gpr17 modulators, method of screening and uses thereof
US11/665,835 US8158593B2 (en) 2004-10-21 2005-10-17 GPR17 modulators, method of screening and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002007A ITMI20042007A1 (it) 2004-10-21 2004-10-21 "modulatori del ricettore gpr17 e loro impieghi terapeutici"

Publications (1)

Publication Number Publication Date
ITMI20042007A1 true ITMI20042007A1 (it) 2005-01-21

Family

ID=35598398

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002007A ITMI20042007A1 (it) 2004-10-21 2004-10-21 "modulatori del ricettore gpr17 e loro impieghi terapeutici"

Country Status (5)

Country Link
US (1) US8158593B2 (it)
EP (1) EP1807701A2 (it)
JP (1) JP2008516617A (it)
IT (1) ITMI20042007A1 (it)
WO (1) WO2006045476A2 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1402549B1 (it) 2010-11-03 2013-09-13 Univ Pisa Composti e composizioni che modulano gpr17 e loro usi terapeutici e diagnostici
EP2727030A4 (en) * 2011-06-29 2015-05-27 Univ Johns Hopkins SYSTEM FOR A THREE-DIMENSIONAL INTERFACE AND DATABASE
EP2567698B1 (en) 2011-09-07 2014-02-12 Rheinische Friedrich-Wilhelms-Universität Bonn GPR 17 agonists and screening assay
KR20150008468A (ko) 2012-05-09 2015-01-22 폰다지오네 이탈리아나 스클레로시 멀티플라 - 에프아이에스엠 온러스 Gpr17 수용체 조절제
DE102016213926B4 (de) * 2016-07-28 2018-10-31 Siemens Healthcare Gmbh Verfahren zur Bestimmung eines Diffusionstensors mittels eines Magnetresonanztomographen und Vorrichtung
TWI754702B (zh) 2016-12-28 2022-02-11 德商Ucb製藥有限公司 (氮雜)吲哚-和苯並呋喃-3-磺醯胺類
KR20210018267A (ko) 2018-05-07 2021-02-17 알닐람 파마슈티칼스 인코포레이티드 간외 전달
SI4074703T1 (sl) * 2018-06-19 2024-03-29 Ucb Pharma Gmbh Piridinil-(aza)indolsulfonamidi
EP3584244A1 (en) 2018-06-20 2019-12-25 UCB Pharma GmbH Substituted alkoxypyridinyl indolsulfonamides
WO2020254289A1 (en) 2019-06-17 2020-12-24 Ucb Pharma Gmbh N-(phenyl)-indole-3-sulfonamide derivatives and related compounds as gpr17 modulators for treating cns disorders such as multiple sclerosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759804A (en) * 1992-11-17 1998-06-02 Icos Corporation Isolated nucleic acid encoding seven transmembrane receptors
WO1996039438A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. G-protein receptor hibeb69
GB0003902D0 (en) * 2000-02-18 2000-04-05 Glaxo Group Ltd Assay
AU2001244205A1 (en) * 2000-03-14 2001-09-24 Bayer Aktiengesellschaft Regulation of human p2y-like gpcr protein
WO2005040829A2 (en) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 17 (gpr17)

Also Published As

Publication number Publication date
JP2008516617A (ja) 2008-05-22
WO2006045476A3 (en) 2006-07-20
WO2006045476A2 (en) 2006-05-04
US8158593B2 (en) 2012-04-17
EP1807701A2 (en) 2007-07-18
US20090156521A1 (en) 2009-06-18

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