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IT1270678B - Liposomi al chetoprofen - Google Patents

Liposomi al chetoprofen

Info

Publication number
IT1270678B
IT1270678B ITMI942142A ITMI942142A IT1270678B IT 1270678 B IT1270678 B IT 1270678B IT MI942142 A ITMI942142 A IT MI942142A IT MI942142 A ITMI942142 A IT MI942142A IT 1270678 B IT1270678 B IT 1270678B
Authority
IT
Italy
Prior art keywords
ketoprofen
liposomes
preparation
phospholipids
solution
Prior art date
Application number
ITMI942142A
Other languages
English (en)
Inventor
Silvana Ciceri
Hans-Jurgen Hamann
Ingrid Hurner
Peter Kurka
Joachim Maasz
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ITMI942142A0 publication Critical patent/ITMI942142A0/it
Priority to ITMI942142A priority Critical patent/IT1270678B/it
Priority to CO95046720A priority patent/CO4480019A1/es
Priority to EP95115899A priority patent/EP0707847A1/de
Priority to US08/542,752 priority patent/US5741515A/en
Priority to JP7290580A priority patent/JPH08208466A/ja
Priority to AU34273/95A priority patent/AU698915B2/en
Priority to CA002160739A priority patent/CA2160739A1/en
Priority to FI954958A priority patent/FI954958A/fi
Priority to NO954177A priority patent/NO954177L/no
Priority to HU9503015A priority patent/HUT73531A/hu
Priority to KR1019950036102A priority patent/KR960013364A/ko
Priority to BR9504463A priority patent/BR9504463A/pt
Priority to ZA958844A priority patent/ZA958844B/xx
Priority to CN95118730A priority patent/CN1130060A/zh
Publication of ITMI942142A1 publication Critical patent/ITMI942142A1/it
Application granted granted Critical
Publication of IT1270678B publication Critical patent/IT1270678B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

La presente invenzione riguarda un gel di liposomi al chetoprofen e un processo per la sua preparazione che si distingue per una modalità di preparazione semplice mediante formazione spontanea di liposomi da fosfolipidi e chetoprofen.Una miscela di chetoprofen e fosfolipidi o anfifili non ionici viene introdotta in una soluzione con un pH da 6 a 8 e in questa soluzione successivamente il pH viene abbassato a valori inferiori a 6, operazione nella quale si perviene alla formazione spontanea di liposomi che eventualmente vengono convertiti con usuali sostanze ausiliarie in una preparazione semisolida o liquida.
ITMI942142A 1994-10-20 1994-10-20 Liposomi al chetoprofen IT1270678B (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ITMI942142A IT1270678B (it) 1994-10-20 1994-10-20 Liposomi al chetoprofen
CO95046720A CO4480019A1 (es) 1994-10-20 1995-10-06 Liposomas de cetoprofeno
EP95115899A EP0707847A1 (de) 1994-10-20 1995-10-09 Ketoprofen Liposomen
US08/542,752 US5741515A (en) 1994-10-20 1995-10-13 Ketoprofen liposomes
JP7290580A JPH08208466A (ja) 1994-10-20 1995-10-13 ケトプロフエンリポソーム
AU34273/95A AU698915B2 (en) 1994-10-20 1995-10-16 Ketoprofen liposomes
CA002160739A CA2160739A1 (en) 1994-10-20 1995-10-17 Ketoprofen liposomes
FI954958A FI954958A (fi) 1994-10-20 1995-10-18 Ketoprofeeniliposomeja
NO954177A NO954177L (no) 1994-10-20 1995-10-19 Ketoprofenliposomer
HU9503015A HUT73531A (en) 1994-10-20 1995-10-19 Ketoprofene liposomes
KR1019950036102A KR960013364A (ko) 1994-10-20 1995-10-19 케토프로펜 리포소옴
BR9504463A BR9504463A (pt) 1994-10-20 1995-10-19 Processo para preparaçao de lipossomas de quetoprofeno e preparaçoes farmacêuticas
ZA958844A ZA958844B (en) 1994-10-20 1995-10-19 Ketoprofen liposomes
CN95118730A CN1130060A (zh) 1994-10-20 1995-10-20 酮苯丙酸脂质体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942142A IT1270678B (it) 1994-10-20 1994-10-20 Liposomi al chetoprofen

Publications (3)

Publication Number Publication Date
ITMI942142A0 ITMI942142A0 (it) 1994-10-20
ITMI942142A1 ITMI942142A1 (it) 1996-04-20
IT1270678B true IT1270678B (it) 1997-05-07

Family

ID=11369741

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942142A IT1270678B (it) 1994-10-20 1994-10-20 Liposomi al chetoprofen

Country Status (14)

Country Link
US (1) US5741515A (it)
EP (1) EP0707847A1 (it)
JP (1) JPH08208466A (it)
KR (1) KR960013364A (it)
CN (1) CN1130060A (it)
AU (1) AU698915B2 (it)
BR (1) BR9504463A (it)
CA (1) CA2160739A1 (it)
CO (1) CO4480019A1 (it)
FI (1) FI954958A (it)
HU (1) HUT73531A (it)
IT (1) IT1270678B (it)
NO (1) NO954177L (it)
ZA (1) ZA958844B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4447287C1 (de) * 1994-12-30 1996-11-07 Cevc Gregor Präparat zum Wirkstofftransport durch Barrieren
US20020048596A1 (en) * 1994-12-30 2002-04-25 Gregor Cevc Preparation for the transport of an active substance across barriers
DE19622224A1 (de) 1996-02-16 1997-08-21 Max Planck Gesellschaft Phosphatidyloligoglycerine
GB9625589D0 (en) 1996-12-10 1997-01-29 Boots Co Plc Therapeutic agents
EP1140021B1 (en) * 1998-12-23 2004-08-04 Idea Ag Improved formulation for topical non-invasive application in vivo
EP1031346B1 (en) 1999-01-27 2002-05-02 Idea Ag Noninvasive vaccination through the skin
DE69901284T2 (de) 1999-01-27 2002-11-28 Idea Ag Transnasaler Transport bzw. Impfung mit hochadaptierbaren Trägern
US6844897B1 (en) * 1999-06-15 2005-01-18 Micron Technology, Inc. Active pixel sensor (APS) readout structure with amplification
MXPA02000053A (es) * 1999-07-05 2003-07-21 Idea Ag Un metodo para mejorar el tratamiento a traves de barreras adaptables semipermeables.
US6610322B1 (en) 2000-12-20 2003-08-26 Brian Charles Keller Self forming, thermodynamically stable liposomes and their applications
US7268924B2 (en) * 2001-01-22 2007-09-11 Hand Held Products, Inc. Optical reader having reduced parameter determination delay
US7785623B2 (en) * 2002-10-01 2010-08-31 Keller Brian C Compositions and methods useful for the reduction of fine lines and wrinkles
US20040105881A1 (en) * 2002-10-11 2004-06-03 Gregor Cevc Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin
CA2584475A1 (en) * 2004-11-12 2006-05-18 Idea Ag Extended surface aggregates in the treatment of skin conditions
WO2007123993A2 (en) * 2006-04-19 2007-11-01 University Of South Florida Niosome-hydrogel drug delivery
US20100068264A1 (en) * 2006-07-12 2010-03-18 University Of South Florida Niosome-hydrogel drug delivery system
EP2405892B1 (en) 2009-03-12 2013-01-16 Advance Holdings Limited Pharmaceutical formulation comprising ketoprofen and a polyoxyalkylene ester of a hydroxy fatty acid
US9522114B1 (en) 2014-03-27 2016-12-20 University Of South Florida Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1110989B (it) * 1979-01-19 1986-01-13 Erba Farmitalia Forme farmaceutiche costitutite da liposomi e procedimenti relativi
IL64397A0 (en) * 1981-01-07 1982-02-28 Weder Hans G Process for the preparation of liposomal medicaments
DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US5008109A (en) * 1984-05-25 1991-04-16 Vestar, Inc. Vesicle stabilization
DE3778972D1 (de) * 1986-06-12 1992-06-17 Liposome Co Inc Mittel unter verwendung liposomverkapselter, nichtsteroider, antiinflammatorischer arzneistoffe.

Also Published As

Publication number Publication date
ITMI942142A0 (it) 1994-10-20
FI954958A0 (fi) 1995-10-18
AU698915B2 (en) 1998-11-12
BR9504463A (pt) 1997-05-20
HUT73531A (en) 1996-08-28
NO954177L (no) 1996-04-22
CO4480019A1 (es) 1997-07-09
ITMI942142A1 (it) 1996-04-20
ZA958844B (en) 1996-05-13
AU3427395A (en) 1996-05-02
EP0707847A1 (de) 1996-04-24
FI954958A (fi) 1996-04-21
JPH08208466A (ja) 1996-08-13
NO954177D0 (no) 1995-10-19
CA2160739A1 (en) 1996-04-21
CN1130060A (zh) 1996-09-04
US5741515A (en) 1998-04-21
KR960013364A (ko) 1996-05-22
HU9503015D0 (en) 1995-12-28

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971029