IT1254134B - Oligonucleotidi antisenso chimicamente modificati. - Google Patents
Oligonucleotidi antisenso chimicamente modificati.Info
- Publication number
- IT1254134B IT1254134B ITRM920025A ITRM920025A IT1254134B IT 1254134 B IT1254134 B IT 1254134B IT RM920025 A ITRM920025 A IT RM920025A IT RM920025 A ITRM920025 A IT RM920025A IT 1254134 B IT1254134 B IT 1254134B
- Authority
- IT
- Italy
- Prior art keywords
- chemically modified
- antisense oligonucleotides
- modified antisense
- residues
- hydrogen
- Prior art date
Links
- 108020000948 Antisense Oligonucleotides Proteins 0.000 title abstract 2
- 239000000074 antisense oligonucleotide Substances 0.000 title abstract 2
- 238000012230 antisense oligonucleotides Methods 0.000 title abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Oligonucleotidi antisenso chimicamente modificati, caratterizzati dal fatto di avere la seguente formula generale (1): (FORMULA I) in cui n è un numero intero da 0 a 200;R1-5 rappresenta una serie di sostituenti, per conferire alla sostituzione una struttura simmetrica nel suo insieme, scelti indipendentemente l'uno dall'altro dal gruppo comprendente idrogeno, eteroatomi, residui con eteroatomi, e residui idrocarbile;R rappresenta idrogeno, sostituenti con eteroatomi oppure residui idrocarbile; e B rappresenta un residuo eterociclico a uno o più anelli, e caratterizzati dal fatto che nella loro molecola sono presenti gruppi fosfato non-ionici e non-chirali.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM920025A IT1254134B (it) | 1992-01-16 | 1992-01-16 | Oligonucleotidi antisenso chimicamente modificati. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM920025A IT1254134B (it) | 1992-01-16 | 1992-01-16 | Oligonucleotidi antisenso chimicamente modificati. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM920025A0 ITRM920025A0 (it) | 1992-01-16 |
| ITRM920025A1 ITRM920025A1 (it) | 1993-07-16 |
| IT1254134B true IT1254134B (it) | 1995-09-08 |
Family
ID=11400569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM920025A IT1254134B (it) | 1992-01-16 | 1992-01-16 | Oligonucleotidi antisenso chimicamente modificati. |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1254134B (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20230300A1 (es) | 2019-12-06 | 2023-02-13 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio |
| PE20241335A1 (es) | 2021-06-04 | 2024-07-03 | Vertex Pharma | N-(hidroxialquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio |
-
1992
- 1992-01-16 IT ITRM920025A patent/IT1254134B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM920025A0 (it) | 1992-01-16 |
| ITRM920025A1 (it) | 1993-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950126 |