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IS2697B - Aðferð til framleiðslu á sítalóprami - Google Patents

Aðferð til framleiðslu á sítalóprami

Info

Publication number
IS2697B
IS2697B IS6091A IS6091A IS2697B IS 2697 B IS2697 B IS 2697B IS 6091 A IS6091 A IS 6091A IS 6091 A IS6091 A IS 6091A IS 2697 B IS2697 B IS 2697B
Authority
IS
Iceland
Prior art keywords
producing citalopram
citalopram
producing
Prior art date
Application number
IS6091A
Other languages
English (en)
Other versions
IS6091A (is
Inventor
Hans Petersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8156954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS2697(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of IS6091A publication Critical patent/IS6091A/is
Publication of IS2697B publication Critical patent/IS2697B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IS6091A 1999-04-14 2001-09-28 Aðferð til framleiðslu á sítalóprami IS2697B (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000210 WO1999030548A2 (en) 1999-04-14 1999-04-14 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
IS6091A IS6091A (is) 2001-09-28
IS2697B true IS2697B (is) 2010-11-15

Family

ID=8156954

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6091A IS2697B (is) 1999-04-14 2001-09-28 Aðferð til framleiðslu á sítalóprami

Country Status (29)

Country Link
US (2) US6849749B2 (is)
EP (1) EP1173431B2 (is)
JP (1) JP3798940B2 (is)
KR (1) KR100604156B1 (is)
CN (1) CN1142926C (is)
AR (1) AR018204A1 (is)
AT (1) ATE237604T1 (is)
AU (1) AU759716B2 (is)
BR (1) BR9917346A (is)
CA (1) CA2291129C (is)
CZ (1) CZ296537B6 (is)
DE (1) DE69907037T3 (is)
DK (1) DK1173431T4 (is)
EA (1) EA004033B1 (is)
ES (1) ES2195554T5 (is)
HK (1) HK1048122B (is)
HU (1) HU227473B1 (is)
IL (1) IL145615A0 (is)
IS (1) IS2697B (is)
IT (1) ITMI991580A1 (is)
MX (1) MXPA01010134A (is)
NO (1) NO327719B1 (is)
NZ (1) NZ514671A (is)
PL (1) PL198024B1 (is)
PT (1) PT1173431E (is)
SI (1) SI1173431T2 (is)
SK (1) SK285604B6 (is)
TR (1) TR200102957T2 (is)
WO (1) WO1999030548A2 (is)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2291134C (en) 1998-10-20 2006-05-23 H. Lundbeck A/S Method for the preparation of citalopram
IL143422A0 (en) 1998-12-23 2002-04-21 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
BR9917346A (pt) 1999-04-14 2002-02-26 Lundbeck & Co As H Método para preparação de citalopram intermadiário e utilização do mesmo
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
TR200101874T1 (tr) 1999-10-25 2002-02-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem
KR100505820B1 (ko) 1999-10-25 2005-08-03 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
PT1246812E (pt) 1999-12-28 2004-08-31 Lundbeck & Co As H Metodo para a preparacao de citalopram
PL198803B1 (pl) 1999-12-30 2008-07-31 Lundbeck & Co As H Sposób wytwarzania 5-cyjano-3H-izobenzofuran-1-onu
CN1195749C (zh) 2000-01-14 2005-04-06 H.隆德贝克有限公司 制备5－氰基2－苯并[c]呋喃酮的方法
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
KR20020080481A (ko) 2000-03-13 2002-10-23 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
JP2003527385A (ja) * 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CN1418205A (zh) 2000-03-14 2003-05-14 H·隆德贝克有限公司 制备西酞普兰的方法
NZ521059A (en) * 2000-03-16 2004-04-30 H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
NL1017525C1 (nl) 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
AU2001100399B4 (en) 2000-12-28 2002-03-21 H Lundbeck As Process for the preparation of pure citalopram
CA2435925A1 (en) 2001-01-30 2002-08-08 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
UA82828C2 (en) * 2001-05-01 2008-05-26 Lundbeck & Co As H The use of enantiomeric pure escitalopram for treatment of depression
KR20040028947A (ko) 2001-07-31 2004-04-03 하. 룬트벡 아크티에 셀스카브 에시탈로프람 함유 결정 조성물
ES2234797T3 (es) * 2001-08-02 2005-07-01 Infosint Sa Procedimiento para la preparacion de citalopram partiendo de 5-formilftalida.
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
WO2003057132A2 (en) 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
DE05815687T1 (de) 2004-08-23 2007-10-18 Sun Pharmaceutical Industries Ltd. Verfahren zur herstellung von citalopram und enantiomeren
CN111533662B (zh) * 2020-04-07 2022-08-23 福建海西新药创制有限公司 一种西酞普兰中间体的合成方法
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (is) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
DE19706648A1 (de) 1997-02-20 1998-08-27 Bayer Ag Verfahren zur Herstellung von aromatischen Nitrilen
JP3526581B2 (ja) * 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CA2291072C (en) 1997-11-11 2002-08-20 H. Lundbeck A/S Method for the preparation of citalopram
CA2291134C (en) † 1998-10-20 2006-05-23 H. Lundbeck A/S Method for the preparation of citalopram
IL143422A0 (en) 1998-12-23 2002-04-21 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
US6331628B1 (en) 1999-03-29 2001-12-18 Nissan Chemical Industries, Ltd. Process for the preparation of benzonitrile compounds
BR9917346A (pt) 1999-04-14 2002-02-26 Lundbeck & Co As H Método para preparação de citalopram intermadiário e utilização do mesmo
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
TR200101874T1 (tr) 1999-10-25 2002-02-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem
JP2003512991A (ja) 1999-10-29 2003-04-08 エクソンモービル リサーチ アンド エンジニアリング カンパニー 微粒子触媒を用いる接触部分酸化方法
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
PT1246812E (pt) 1999-12-28 2004-08-31 Lundbeck & Co As H Metodo para a preparacao de citalopram
PL198803B1 (pl) 1999-12-30 2008-07-31 Lundbeck & Co As H Sposób wytwarzania 5-cyjano-3H-izobenzofuran-1-onu
CN1195749C (zh) 2000-01-14 2005-04-06 H.隆德贝克有限公司 制备5－氰基2－苯并[c]呋喃酮的方法
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
KR20020080481A (ko) 2000-03-13 2002-10-23 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
CN1418205A (zh) 2000-03-14 2003-05-14 H·隆德贝克有限公司 制备西酞普兰的方法
NZ521059A (en) 2000-03-16 2004-04-30 H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
BR0106976A (pt) 2000-07-06 2002-07-23 Lundbeck & Co As H Método para a preparação de citalopram
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
NL1017525C1 (nl) 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
AU2001100399B4 (en) 2000-12-28 2002-03-21 H Lundbeck As Process for the preparation of pure citalopram
KR20040028947A (ko) 2001-07-31 2004-04-03 하. 룬트벡 아크티에 셀스카브 에시탈로프람 함유 결정 조성물

Also Published As

Publication number Publication date
WO1999030548A2 (en) 1999-06-24
PT1173431E (pt) 2003-09-30
ITMI991580A0 (it) 1999-07-15
AU3137899A (en) 1999-07-05
KR100604156B1 (ko) 2006-07-25
DK1173431T4 (da) 2010-01-04
HUP0200678A3 (en) 2002-09-30
DE69907037D1 (de) 2003-05-22
CA2291129A1 (en) 1999-06-24
US20020040153A1 (en) 2002-04-04
CN1142926C (zh) 2004-03-24
KR20010112421A (ko) 2001-12-20
US7030252B2 (en) 2006-04-18
AR018204A1 (es) 2001-10-31
CZ20013693A3 (cs) 2002-02-13
HK1048122B (zh) 2005-01-14
EP1173431A2 (en) 2002-01-23
EA200101081A1 (ru) 2002-04-25
DE69907037T2 (de) 2004-01-29
DE69907037T3 (de) 2010-02-18
NZ514671A (en) 2003-10-31
WO1999030548B1 (en) 2000-03-16
TR200102957T2 (tr) 2004-12-21
JP2002509864A (ja) 2002-04-02
US6849749B2 (en) 2005-02-01
EP1173431B1 (en) 2003-04-16
ES2195554T5 (es) 2010-02-02
US20050124817A1 (en) 2005-06-09
HU227473B1 (en) 2011-07-28
PL350803A1 (en) 2003-02-10
IL145615A0 (en) 2002-06-30
SK285604B6 (sk) 2007-04-05
EP1173431B2 (en) 2009-08-26
SI1173431T1 (en) 2003-08-31
ITMI991580A1 (it) 2001-01-15
HUP0200678A2 (hu) 2002-07-29
SI1173431T2 (sl) 2009-12-31
SK14402001A3 (sk) 2002-04-04
BR9917346A (pt) 2002-02-26
DK1173431T3 (da) 2003-08-04
CZ296537B6 (cs) 2006-04-12
EA004033B1 (ru) 2003-12-25
ES2195554T3 (es) 2003-12-01
NO327719B1 (no) 2009-09-14
MXPA01010134A (es) 2002-04-15
AU759716B2 (en) 2003-04-17
WO1999030548A3 (en) 2000-02-10
IS6091A (is) 2001-09-28
NO20015017L (no) 2001-10-15
PL198024B1 (pl) 2008-05-30
JP3798940B2 (ja) 2006-07-19
CA2291129C (en) 2002-10-22
HK1048122A1 (en) 2003-03-21
ATE237604T1 (de) 2003-05-15
NO20015017D0 (no) 2001-10-15
CN1359382A (zh) 2002-07-17

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