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BR9917346A - Método para preparação de citalopram intermadiário e utilização do mesmo - Google Patents

Método para preparação de citalopram intermadiário e utilização do mesmo

Info

Publication number
BR9917346A
BR9917346A BR9917346-8A BR9917346A BR9917346A BR 9917346 A BR9917346 A BR 9917346A BR 9917346 A BR9917346 A BR 9917346A BR 9917346 A BR9917346 A BR 9917346A
Authority
BR
Brazil
Prior art keywords
citalopram
preparing intermediate
preparation
compound
oxaxii
Prior art date
Application number
BR9917346-8A
Other languages
English (en)
Inventor
Hans Peterson
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8156954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9917346(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR9917346A publication Critical patent/BR9917346A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"MéTODO PARA PREPARAçãO DE CITALOPRAM INTERMEDIáRIO E UTILIZAçãO DO MESMO". Provê-se um método para a preparação de citalopram compreendendo hidrólise redutora de um composto de Fórmula (IV), onde R é um grupo amida N,N-bisubstituído ou um grupo 4,5-diidro-1,3-oxaxii-2-il opcionalmente substituído, e conversão do composto 5-formil resultante em citalopram.
BR9917346-8A 1999-04-14 1999-04-14 Método para preparação de citalopram intermadiário e utilização do mesmo BR9917346A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000210 WO1999030548A2 (en) 1999-04-14 1999-04-14 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
BR9917346A true BR9917346A (pt) 2002-02-26

Family

ID=8156954

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9917346-8A BR9917346A (pt) 1999-04-14 1999-04-14 Método para preparação de citalopram intermadiário e utilização do mesmo

Country Status (29)

Country Link
US (2) US6849749B2 (pt)
EP (1) EP1173431B2 (pt)
JP (1) JP3798940B2 (pt)
KR (1) KR100604156B1 (pt)
CN (1) CN1142926C (pt)
AR (1) AR018204A1 (pt)
AT (1) ATE237604T1 (pt)
AU (1) AU759716B2 (pt)
BR (1) BR9917346A (pt)
CA (1) CA2291129C (pt)
CZ (1) CZ296537B6 (pt)
DE (1) DE69907037T3 (pt)
DK (1) DK1173431T4 (pt)
EA (1) EA004033B1 (pt)
ES (1) ES2195554T5 (pt)
HK (1) HK1048122B (pt)
HU (1) HU227473B1 (pt)
IL (1) IL145615A0 (pt)
IS (1) IS2697B (pt)
IT (1) ITMI991580A1 (pt)
MX (1) MXPA01010134A (pt)
NO (1) NO327719B1 (pt)
NZ (1) NZ514671A (pt)
PL (1) PL198024B1 (pt)
PT (1) PT1173431E (pt)
SI (1) SI1173431T2 (pt)
SK (1) SK285604B6 (pt)
TR (1) TR200102957T2 (pt)
WO (1) WO1999030548A2 (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU746665B2 (en) 1998-10-20 2002-05-02 H. Lundbeck A/S Method for the preparation of citalopram
BR9916955A (pt) 1998-12-23 2001-09-11 Lundbeck & Co As H Método para preparação de 5-cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
NZ514671A (en) 1999-04-14 2003-10-31 H Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
TR200101874T1 (tr) 1999-10-25 2002-02-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem
DK1228056T3 (da) 1999-10-25 2005-01-24 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
SK9282002A3 (en) 1999-12-28 2002-11-06 Lundbeck & Co As H Method for the preparation of citalopram, pharmaceutical composition comprising same and intermediates
ATE253568T1 (de) 1999-12-30 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
MXPA02006915A (es) 2000-01-14 2002-10-23 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
SK14522002A3 (sk) 2000-03-13 2003-03-04 H. Lundbeck A/S Spôsob prípravy citalopramu a citalopram pripravený týmto spôsobom
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IL151490A0 (en) 2000-03-13 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
WO2001068630A1 (en) 2000-03-14 2001-09-20 H. Lundbeck A/S Method for the preparation of citalopram
CH692148A5 (de) * 2000-03-16 2002-02-28 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011621L (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
NL1017525C1 (nl) 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
HK1049332A1 (zh) 2000-12-28 2003-05-09 H‧隆德贝克有限公司 純西酞普蘭的製備方法
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
SK14612003A3 (sk) * 2001-05-01 2004-04-06 H. Lundbeck A/S Použitie enantiomérne čistého escitalopramu a farmaceutický prostriedok s obsahom escitalopramu
KR20040028947A (ko) 2001-07-31 2004-04-03 하. 룬트벡 아크티에 셀스카브 에시탈로프람 함유 결정 조성물
ES2234797T3 (es) * 2001-08-02 2005-07-01 Infosint Sa Procedimiento para la preparacion de citalopram partiendo de 5-formilftalida.
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
WO2003057132A2 (en) 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
EP1797060A2 (en) 2004-08-23 2007-06-20 Sun Pharmaceutical Industries Limited "process for preparation of citalopram and enantiomers"
CN111533662B (zh) * 2020-04-07 2022-08-23 福建海西新药创制有限公司 一种西酞普兰中间体的合成方法
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

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GB1143702A (pt) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
DE19706648A1 (de) 1997-02-20 1998-08-27 Bayer Ag Verfahren zur Herstellung von aromatischen Nitrilen
DE69801764T2 (de) * 1997-07-08 2002-07-04 H. Lundbeck A/S, Kobenhavn-Valby Verfahren zur herstellung von citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DK1042310T3 (da) 1997-11-11 2002-12-02 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
AU746665B2 (en) † 1998-10-20 2002-05-02 H. Lundbeck A/S Method for the preparation of citalopram
BR9916955A (pt) 1998-12-23 2001-09-11 Lundbeck & Co As H Método para preparação de 5-cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
US6331628B1 (en) 1999-03-29 2001-12-18 Nissan Chemical Industries, Ltd. Process for the preparation of benzonitrile compounds
NZ514671A (en) 1999-04-14 2003-10-31 H Method for the preparation of citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
TR200101874T1 (tr) * 1999-10-25 2002-02-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem
WO2001032556A1 (en) 1999-10-29 2001-05-10 Exxon Research And Engineering Company Process for catalytic partial oxidation using particulate catalysts
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
SK9282002A3 (en) 1999-12-28 2002-11-06 Lundbeck & Co As H Method for the preparation of citalopram, pharmaceutical composition comprising same and intermediates
ATE253568T1 (de) 1999-12-30 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
MXPA02006915A (es) 2000-01-14 2002-10-23 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) * 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IL151490A0 (en) 2000-03-13 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
SK14522002A3 (sk) 2000-03-13 2003-03-04 H. Lundbeck A/S Spôsob prípravy citalopramu a citalopram pripravený týmto spôsobom
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
WO2001068630A1 (en) 2000-03-14 2001-09-20 H. Lundbeck A/S Method for the preparation of citalopram
CH692148A5 (de) 2000-03-16 2002-02-28 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2383963A1 (en) 2000-07-06 2002-01-17 Eva Bolzonella Method for the preparation of citalopram
FI20011621L (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
NL1017525C1 (nl) 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
HK1049332A1 (zh) 2000-12-28 2003-05-09 H‧隆德贝克有限公司 純西酞普蘭的製備方法
KR20040028947A (ko) 2001-07-31 2004-04-03 하. 룬트벡 아크티에 셀스카브 에시탈로프람 함유 결정 조성물

Also Published As

Publication number Publication date
US6849749B2 (en) 2005-02-01
DK1173431T3 (da) 2003-08-04
WO1999030548A2 (en) 1999-06-24
NO327719B1 (no) 2009-09-14
SI1173431T2 (sl) 2009-12-31
CN1142926C (zh) 2004-03-24
SK14402001A3 (sk) 2002-04-04
US20050124817A1 (en) 2005-06-09
PL350803A1 (en) 2003-02-10
CA2291129A1 (en) 1999-06-24
WO1999030548B1 (en) 2000-03-16
SK285604B6 (sk) 2007-04-05
HK1048122A1 (en) 2003-03-21
PL198024B1 (pl) 2008-05-30
DE69907037D1 (de) 2003-05-22
EP1173431A2 (en) 2002-01-23
SI1173431T1 (en) 2003-08-31
NZ514671A (en) 2003-10-31
DE69907037T2 (de) 2004-01-29
DE69907037T3 (de) 2010-02-18
MXPA01010134A (es) 2002-04-15
EA200101081A1 (ru) 2002-04-25
HUP0200678A2 (hu) 2002-07-29
HUP0200678A3 (en) 2002-09-30
WO1999030548A3 (en) 2000-02-10
TR200102957T2 (tr) 2004-12-21
IS6091A (is) 2001-09-28
AR018204A1 (es) 2001-10-31
ITMI991580A1 (it) 2001-01-15
CZ20013693A3 (cs) 2002-02-13
EP1173431B1 (en) 2003-04-16
CZ296537B6 (cs) 2006-04-12
ATE237604T1 (de) 2003-05-15
EA004033B1 (ru) 2003-12-25
ES2195554T3 (es) 2003-12-01
KR100604156B1 (ko) 2006-07-25
JP3798940B2 (ja) 2006-07-19
NO20015017L (no) 2001-10-15
PT1173431E (pt) 2003-09-30
NO20015017D0 (no) 2001-10-15
ITMI991580A0 (it) 1999-07-15
US7030252B2 (en) 2006-04-18
CA2291129C (en) 2002-10-22
US20020040153A1 (en) 2002-04-04
CN1359382A (zh) 2002-07-17
JP2002509864A (ja) 2002-04-02
IL145615A0 (en) 2002-06-30
DK1173431T4 (da) 2010-01-04
AU759716B2 (en) 2003-04-17
ES2195554T5 (es) 2010-02-02
HK1048122B (zh) 2005-01-14
HU227473B1 (en) 2011-07-28
IS2697B (is) 2010-11-15
EP1173431B2 (en) 2009-08-26
AU3137899A (en) 1999-07-05
KR20010112421A (ko) 2001-12-20

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