IL98163A - Isoxazole-4-carboxamides and hydroxyalkylidenzano azamides, and new compounds of this type - Google Patents

Isoxazole-4-carboxamides and hydroxyalkylidenzano azamides, and new compounds of this type

Info

Publication number: IL98163A
Authority: IL; Israel
Prior art keywords: carbon atoms; alkyl; mono; halogen; bromine
Prior art date: 1990-05-18

Application number

IL9816391A

Other languages

English (en)

Hebrew (he)

Other versions

IL98163A0 (en

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-18

Filing date

1991-05-16

Publication date

1996-01-31

1991-05-16 Application filed by Hoechst Ag filed Critical Hoechst Ag

1992-06-21 Publication of IL98163A0 publication Critical patent/IL98163A0/xx

1996-01-31 Publication of IL98163A publication Critical patent/IL98163A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/40—Y being a hydrogen or a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Hydrogenated Pyridines (AREA)
Air Conditioning Control Device (AREA)
Photoreceptors In Electrophotography (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)

IL9816391A 1990-05-18 1991-05-16 Isoxazole-4-carboxamides and hydroxyalkylidenzano azamides, and new compounds of this type IL98163A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4016178		1990-05-18
DE4017043		1990-05-26
DE4017020		1990-05-26

Publications (2)

Publication Number	Publication Date
IL98163A0 IL98163A0 (en)	1992-06-21
IL98163A true IL98163A (en)	1996-01-31

Family

ID=27201216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9816391A IL98163A (en)	1990-05-18	1991-05-16	Isoxazole-4-carboxamides and hydroxyalkylidenzano azamides, and new compounds of this type

Country Status (28)

Country	Link
US (2)	US5494911A (ja)
EP (1)	EP0527736B1 (ja)
JP (3)	JP2995086B2 (ja)
KR (1)	KR100188801B1 (ja)
CN (1)	CN1051074C (ja)
AT (1)	ATE151633T1 (ja)
AU (2)	AU649421B2 (ja)
BR (1)	BR9008022A (ja)
CA (1)	CA2083179C (ja)
CY (1)	CY2123B1 (ja)
CZ (4)	CZ290474B6 (ja)
DE (1)	DE59010701D1 (ja)
DK (1)	DK0527736T3 (ja)
ES (1)	ES2102367T3 (ja)
FI (1)	FI105683B (ja)
GR (1)	GR3023638T3 (ja)
HU (1)	HU222234B1 (ja)
IE (1)	IE911694A1 (ja)
IL (1)	IL98163A (ja)
LV (1)	LV10575B (ja)
NO (1)	NO180118C (ja)
NZ (1)	NZ238165A (ja)
PT (1)	PT97689B (ja)
RU (2)	RU2084223C1 (ja)
SK (3)	SK281318B6 (ja)
TW (2)	TW211558B (ja)
WO (1)	WO1991017748A1 (ja)
YU (1)	YU48765B (ja)

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1990
- 1990-10-24 JP JP2514415A patent/JP2995086B2/ja not_active Expired - Lifetime
- 1990-10-24 EP EP90915462A patent/EP0527736B1/de not_active Expired - Lifetime
- 1990-10-24 HU HU9203619A patent/HU222234B1/hu active IP Right Grant
- 1990-10-24 RU RU9092016445A patent/RU2084223C1/ru active
- 1990-10-24 RU RU94033835A patent/RU2142937C1/ru active
- 1990-10-24 US US07/938,048 patent/US5494911A/en not_active Expired - Lifetime
- 1990-10-24 ES ES90915462T patent/ES2102367T3/es not_active Expired - Lifetime
- 1990-10-24 BR BR909008022A patent/BR9008022A/pt not_active Application Discontinuation
- 1990-10-24 CA CA002083179A patent/CA2083179C/en not_active Expired - Lifetime
- 1990-10-24 KR KR1019920702895A patent/KR100188801B1/ko not_active IP Right Cessation
- 1990-10-24 AU AU65468/90A patent/AU649421B2/en not_active Expired
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- 1990-10-24 WO PCT/EP1990/001800 patent/WO1991017748A1/de active IP Right Grant
- 1990-10-24 DK DK90915462.7T patent/DK0527736T3/da active
- 1990-10-24 AT AT90915462T patent/ATE151633T1/de not_active IP Right Cessation
- 1990-10-27 TW TW081101406A patent/TW211558B/zh active
- 1990-10-27 TW TW079109110A patent/TW205004B/zh active
1991
- 1991-05-16 NZ NZ238165A patent/NZ238165A/en not_active IP Right Cessation
- 1991-05-16 IL IL9816391A patent/IL98163A/en not_active IP Right Cessation
- 1991-05-16 PT PT97689A patent/PT97689B/pt not_active IP Right Cessation
- 1991-05-16 SK SK542-99A patent/SK281318B6/sk not_active IP Right Cessation
- 1991-05-16 SK SK1376-98A patent/SK281317B6/sk not_active IP Right Cessation
- 1991-05-16 CN CN91103182A patent/CN1051074C/zh not_active Expired - Lifetime
- 1991-05-16 SK SK1450-91A patent/SK281316B6/sk not_active IP Right Cessation
- 1991-05-16 CZ CS19911450A patent/CZ290474B6/cs not_active IP Right Cessation
- 1991-05-17 IE IE169491A patent/IE911694A1/en not_active IP Right Cessation
- 1991-05-20 YU YU88491A patent/YU48765B/sr unknown
1992
- 1992-11-17 NO NO924433A patent/NO180118C/no not_active IP Right Cessation
- 1992-11-17 FI FI925211A patent/FI105683B/fi active
1993
- 1993-05-07 LV LVP-93-310A patent/LV10575B/en unknown
1994
- 1994-03-23 AU AU57992/94A patent/AU662465B2/en not_active Expired
1995
- 1995-06-07 US US08/476,278 patent/US5532259A/en not_active Expired - Lifetime
- 1995-08-24 CZ CZ19952176A patent/CZ290717B6/cs not_active IP Right Cessation
- 1995-11-23 CZ CZ19953092A patent/CZ290737B6/cs not_active IP Right Cessation
- 1995-11-23 CZ CZ19953091A patent/CZ290736B6/cs not_active IP Right Cessation
1997
- 1997-05-30 GR GR970401284T patent/GR3023638T3/el unknown
1998
- 1998-09-29 CY CY9800032A patent/CY2123B1/xx unknown
1999
- 1999-03-01 JP JP05210899A patent/JP3233610B2/ja not_active Expired - Lifetime
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Also Published As

Publication number	Publication date
HU9203619D0 (en)	1993-03-29
EP0527736B1 (de)	1997-04-16
JP3233610B2 (ja)	2001-11-26
CN1051074C (zh)	2000-04-05
JP3201747B2 (ja)	2001-08-27
GR3023638T3 (en)	1997-08-29
CS145091A3 (en)	1992-01-15
HU222234B1 (hu)	2003-05-28
US5494911A (en)	1996-02-27
JPH11343285A (ja)	1999-12-14
EP0527736A1 (de)	1993-02-24
SK281316B6 (sk)	2001-02-12
RU94033835A (ru)	1996-04-20
JPH11322700A (ja)	1999-11-24
JPH05506425A (ja)	1993-09-22
CZ290736B6 (cs)	2002-10-16
TW211558B (ja)	1993-08-21
NO924433L (no)	1992-11-17
KR100188801B1 (ko)	1999-06-01
CZ290717B6 (cs)	2002-10-16
IE911694A1 (en)	1991-11-20
FI925211A0 (fi)	1992-11-17
SK281318B6 (sk)	2001-02-12
BR9008022A (pt)	1993-04-06
NO180118B (no)	1996-11-11
AU5799294A (en)	1994-07-07
CA2083179C (en)	2001-10-23
CY2123B1 (en)	2002-06-21
CA2083179A1 (en)	1991-11-19
NO924433D0 (no)	1992-11-17
DK0527736T3 (da)	1997-10-20
PT97689B (pt)	1998-09-30
SK281317B6 (sk)	2001-02-12
RU2142937C1 (ru)	1999-12-20
JP2995086B2 (ja)	1999-12-27
HUT64314A (en)	1993-12-28
NZ238165A (en)	1994-08-26
DE59010701D1 (de)	1997-05-22
YU88491A (sh)	1995-03-27
FI105683B (fi)	2000-09-29
NO180118C (no)	1997-02-19
ATE151633T1 (de)	1997-05-15
AU6546890A (en)	1991-12-10
TW205004B (ja)	1993-05-01
AU662465B2 (en)	1995-08-31
YU48765B (en)	1999-11-22
CN1056684A (zh)	1991-12-04
CZ290474B6 (cs)	2002-07-17
LV10575B (en)	1996-04-20
IL98163A0 (en)	1992-06-21
US5532259A (en)	1996-07-02
CZ290737B6 (cs)	2002-10-16
WO1991017748A1 (de)	1991-11-28
LV10575A (lv)	1995-04-20
RU2084223C1 (ru)	1997-07-20
AU649421B2 (en)	1994-05-26
PT97689A (pt)	1992-02-28
ES2102367T3 (es)	1997-08-01
FI925211A (fi)	1992-11-17

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PT1651232E (pt)	2011-02-16	Compostos para inflamação e utilizações imunorelacionadas
CN111153846B (zh)	2021-08-31	吡咯类化合物、其制备方法和药物组合物与用途
EP1103543A1 (en)	2001-05-30	Novel urea derivatives bearing nitrogenous aromatic heterocycles
US4542139A (en)	1985-09-17	Sulfonylureas pharmaceutical formulations based on these compounds and their use for treatment of diabetes
JPH02167272A (ja)	1990-06-27	エタンスルホンアミド誘導体
FI105680B (fi)	2000-09-29	Menetelmä terapeuttisesti käyttökelpoisten hydroksialkylideenisyaanietikkahappoamidien valmistamiseksi
LT3416B (en)	1995-09-25	Isoxazole-4-carboxamides, hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and method for the preparation of such drugs
US4402964A (en)	1983-09-06	N-Aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)ureas useful for the treatment of epilepsy
Sontakke et al.	0	CONVENIENT ROUTE FOR STUDYING REACTIVITY OF ISOTHIOCYANATES TOWARDS BARBITURYL ISOTHIOCARBAMIDE

Legal Events

Date	Code	Title
1996-07-23	FF	Patent granted
1997-09-30	KB	Patent renewed
2001-07-24	KB	Patent renewed
2001-08-26	HP	Change in proprietorship
2009-11-18	KB	Patent renewed
2011-12-29	EXP	Patent expired