IL67470A0 - Phosphorus containing compounds - Google Patents

Phosphorus containing compounds

Info

Publication number: IL67470A0
Authority: IL; Israel
Prior art keywords: containing compounds; phosphorus containing; compounds; isthese; formulawherein
Prior art date: 1981-12-24

Application number

IL67470A

Other languages

English (en)

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-12-24

Filing date

1982-12-14

Publication date

1983-05-15

1982-12-14 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1983-05-15 Publication of IL67470A0 publication Critical patent/IL67470A0/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 3
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title abstract 2
229910052698 phosphorus Inorganic materials 0.000 title abstract 2
239000011574 phosphorus Substances 0.000 title abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000005555 hypertensive agent Substances 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65615—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing a spiro condensed ring system of the formula where at least one of the atoms X or Y is a hetero atom, e.g. S
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/306—Arylalkanephosphinic acids, e.g. Ar-(CH2)n-P(=X)(R)(XH), (X = O,S, Se; n>=1)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3241—Esters of arylalkanephosphinic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4484—Compounds containing the structure C-P(=X)(N-acyl)-X, C-P(=X)(N-heteroatom)-X or C-P(=X)(N-CN)-X (X = O, S, Se)
- C07F9/4492—Compounds containing the structure P(=X)(N-C(=X)-) (X = O, S, Se)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
- C07F9/4808—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
- C07F9/4816—Acyclic saturated acids or derivatices which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/62—Isoquinoline or hydrogenated isoquinoline ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Crystallography & Structural Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Anti-Oxidant Or Stabilizer Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Fats And Perfumes (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL67470A 1981-12-24 1982-12-14 Phosphorus containing compounds IL67470A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/334,271 US4555506A (en)	1981-12-24	1981-12-24	Phosphorus containing compounds and use as hypotensives

Publications (1)

Publication Number	Publication Date
IL67470A0 true IL67470A0 (en)	1983-05-15

Family

ID=23306429

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL67470A IL67470A0 (en)	1981-12-24	1982-12-14	Phosphorus containing compounds

Country Status (19)

Country	Link
US (1)	US4555506A (da)
EP (1)	EP0083172B1 (da)
JP (1)	JPS58118596A (da)
AT (1)	ATE29723T1 (da)
AU (1)	AU549460B2 (da)
CA (1)	CA1197852A (da)
DE (1)	DE3277302D1 (da)
DK (1)	DK572182A (da)
ES (5)	ES518503A0 (da)
FI (1)	FI75832C (da)
GR (1)	GR78434B (da)
HU (1)	HU189207B (da)
IE (1)	IE54133B1 (da)
IL (1)	IL67470A0 (da)
NO (1)	NO824359L (da)
NZ (1)	NZ202762A (da)
PH (1)	PH20523A (da)
PT (1)	PT76028B (da)
ZA (1)	ZA829198B (da)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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US4716155A (en) *	1981-12-24	1987-12-29	E. R. Squibb & Sons, Inc.	Phosphorus containing compounds and hypotensive use thereof
US4452790A (en) *	1982-06-23	1984-06-05	E. R. Squibb & Sons, Inc.	Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
USH642H (en)	1984-08-20	1989-06-06	E. R. Squibb & Sons, Inc.	Substituted urido amino and imino acids and esters
US4634689A (en) *	1985-10-31	1987-01-06	Schering Corporation	Phosphinylalkanoyl imino acids
CA1307787C (en) *	1986-06-11	1992-09-22	Melanie J. Loots	Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors
US4849414A (en) *	1986-06-11	1989-07-18	E. R. Squibb & Sons, Inc.	Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors
EP0566157A1 (en)	1986-06-20	1993-10-20	Schering Corporation	Neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0254032A3 (en)	1986-06-20	1990-09-05	Schering Corporation	Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US4749688A (en) *	1986-06-20	1988-06-07	Schering Corporation	Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
CA1306749C (en) *	1986-07-14	1992-08-25	Donald S. Karanewsky	.alpha.-ACYLAMINO AMINOALKYL PHOSPHONATE ANGIOTENSIN CONVERTING ENZYME INHIBITORS
US5262436A (en) *	1987-03-27	1993-11-16	Schering Corporation	Acylamino acid antihypertensives in the treatment of congestive heart failure
CA1321753C (en) *	1987-04-27	1993-08-31	Abraham Sudilovsky	Method for inhibiting loss of cognitive functions employing an ace inhibitor
WO1989007940A1 (en) *	1988-03-03	1989-09-08	E.R. Squibb & Sons, Inc.	1,2-hydroxy phosphonates and derivatives thereof
JP2733511B2 (ja) *	1988-10-22	1998-03-30	日本臓器製薬株式会社	新規アミノアルカン誘導体
ZA902661B (en) *	1989-04-10	1991-01-30	Schering Corp	Mercapto-acyl amino acids
CA2069112A1 (en) *	1989-11-21	1991-05-22	Bernard R. Neustadt	Carboxyalkylcarbonyl aminoacid endopeptidase inhibitors
US5407960A (en) *	1989-12-22	1995-04-18	Schering Corporation	Mercaptocycloacyl aminoacid endopeptidase inhibitors
US5075302A (en) *	1990-03-09	1991-12-24	Schering Corporation	Mercaptoacyl aminolactam endopeptidase inhibitors
US5173506A (en) *	1990-08-16	1992-12-22	Schering Corporation	N-(mercaptoalkyl)ureas and carbamates
PT778263E (pt) *	1994-08-22	2002-06-28	Mitsubishi Pharma Corp	Composto de benzeno e sua utilizacao farmaceutica
US5948820A (en) *	1994-08-22	1999-09-07	Yoshitomi Pharmaceutical Industries, Ltd.	Benzene compound and pharmaceutical use thereof
US6011021A (en) *	1996-06-17	2000-01-04	Guilford Pharmaceuticals Inc.	Methods of cancer treatment using naaladase inhibitors
US5795877A (en) *	1996-12-31	1998-08-18	Guilford Pharmaceuticals Inc.	Inhibitors of NAALADase enzyme activity
US6054444A (en) *	1997-04-24	2000-04-25	Guilford Pharmaceuticals Inc.	Phosphonic acid derivatives
US5863536A (en) *	1996-12-31	1999-01-26	Guilford Pharmaceuticals Inc.	Phosphoramidate derivatives
AU725455B2 (en)	1996-06-17	2000-10-12	Guilford Pharmaceuticals Inc.	Methods of cancer treatment using NAALADase inhibitors
US6025345A (en) *	1996-06-17	2000-02-15	Guilford Pharmaceuticals Inc.	Inhibitors of NAALADase enzyme activity
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1981
- 1981-12-24 US US06/334,271 patent/US4555506A/en not_active Expired - Fee Related
1982
- 1982-12-07 CA CA000417205A patent/CA1197852A/en not_active Expired
- 1982-12-09 PH PH28251A patent/PH20523A/en unknown
- 1982-12-09 NZ NZ202762A patent/NZ202762A/en unknown
- 1982-12-13 EP EP82306647A patent/EP0083172B1/en not_active Expired
- 1982-12-13 DE DE8282306647T patent/DE3277302D1/de not_active Expired
- 1982-12-13 AT AT82306647T patent/ATE29723T1/de not_active IP Right Cessation
- 1982-12-14 ZA ZA829198A patent/ZA829198B/xx unknown
- 1982-12-14 AU AU91494/82A patent/AU549460B2/en not_active Ceased
- 1982-12-14 IL IL67470A patent/IL67470A0/xx not_active IP Right Cessation
- 1982-12-20 GR GR70113A patent/GR78434B/el unknown
- 1982-12-21 IE IE3045/82A patent/IE54133B1/en not_active IP Right Cessation
- 1982-12-22 HU HU824136A patent/HU189207B/hu not_active IP Right Cessation
- 1982-12-22 FI FI824424A patent/FI75832C/fi not_active IP Right Cessation
- 1982-12-23 ES ES518503A patent/ES518503A0/es active Granted
- 1982-12-23 NO NO824359A patent/NO824359L/no unknown
- 1982-12-23 PT PT76028A patent/PT76028B/pt not_active IP Right Cessation
- 1982-12-23 DK DK572182A patent/DK572182A/da not_active Application Discontinuation
- 1982-12-24 JP JP57235033A patent/JPS58118596A/ja active Pending
1984
- 1984-03-15 ES ES530633A patent/ES8600316A1/es not_active Expired
- 1984-03-15 ES ES530635A patent/ES530635A0/es active Granted
- 1984-03-15 ES ES530634A patent/ES8600317A1/es not_active Expired
1985
- 1985-06-12 ES ES544088A patent/ES8604244A1/es not_active Expired

Also Published As

Publication number	Publication date
CA1197852A (en)	1985-12-10
AU549460B2 (en)	1986-01-30
GR78434B (da)	1984-09-27
ES8405809A1 (es)	1984-06-16
ZA829198B (en)	1983-09-28
DK572182A (da)	1983-06-25
FI75832B (fi)	1988-04-29
ES530633A0 (es)	1985-10-01
FI75832C (fi)	1988-08-08
IE54133B1 (en)	1989-06-21
ES530634A0 (es)	1985-10-01
NO824359L (no)	1983-06-27
ES8604244A1 (es)	1986-01-16
FI824424A0 (fi)	1982-12-22
ATE29723T1 (de)	1987-10-15
HU189207B (en)	1986-06-30
EP0083172B1 (en)	1987-09-16
PH20523A (en)	1987-01-30
AU9149482A (en)	1983-06-30
NZ202762A (en)	1986-07-11
ES8600317A1 (es)	1985-10-01
ES544088A0 (es)	1986-01-16
PT76028B (en)	1985-11-18
PT76028A (en)	1983-01-01
ES8602029A1 (es)	1985-11-01
EP0083172A3 (en)	1984-08-08
ES530635A0 (es)	1985-11-01
US4555506A (en)	1985-11-26
JPS58118596A (ja)	1983-07-14
ES518503A0 (es)	1984-06-16
DE3277302D1 (en)	1987-10-22
IE823045L (en)	1983-06-24
ES8600316A1 (es)	1985-10-01
FI824424L (fi)	1983-06-25
EP0083172A2 (en)	1983-07-06

Publication	Publication Date	Title
DE3277302D1 (en)	1987-10-22	Phosphorus containing compounds
DE3368639D1 (en)	1987-02-05	Amino and substituted amino phosphinylalkanoyl compounds
ZA822577B (en)	1983-03-30	Amino and substituted amino phosphinylalkanoyl compounds
EP0097534A3 (en)	1984-12-12	Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
ZA854170B (en)	1986-01-29	Assay of perioxidase enzyme activity
ATE30429T1 (de)	1987-11-15	Acylamino-oxo- oder hydroxy-substituiertealkylamino thiazine und thiazepine.
DE3273628D1 (en)	1986-11-13	Phosphonamidate compounds
AU583499B2 (en)	1989-05-04	Amino thiol dipeptides
NZ207161A (en)	1986-11-12	3-formyl-2-nitromethylene-tetrahydro-2h-1,3-thiazine and pesticidal compositions
AU7409487A (en)	1987-12-17	Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors
SU1167881A1 (ru)	1996-03-27	Фенилгидразид морфолинодиэтилуксусной кислоты, обладающий противотуберкулезным действием
ZA853670B (en)	1985-12-24	Substituted lactams useful as angiotensin converting enzyme inhibitors
CA1270350C (en)	1990-06-12	AMINO THIO DIPEPTIDES
ZA827665B (en)	1984-06-27	Angiotensin converting enzyme inhibitor compound

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1997-11-20	RH	Patent void