ATE30429T1 - Acylamino-oxo- oder hydroxy-substituiertealkylamino thiazine und thiazepine. - Google Patents
Acylamino-oxo- oder hydroxy-substituiertealkylamino thiazine und thiazepine.Info
- Publication number
- ATE30429T1 ATE30429T1 AT85102280T AT85102280T ATE30429T1 AT E30429 T1 ATE30429 T1 AT E30429T1 AT 85102280 T AT85102280 T AT 85102280T AT 85102280 T AT85102280 T AT 85102280T AT E30429 T1 ATE30429 T1 AT E30429T1
- Authority
- AT
- Austria
- Prior art keywords
- thiazepine
- thiazine
- oxo
- acylamino
- alkylamino
- Prior art date
Links
- NYERMPLPURRVGM-UHFFFAOYSA-N thiazepine Chemical compound S1C=CC=CC=N1 NYERMPLPURRVGM-UHFFFAOYSA-N 0.000 title abstract 2
- AGIJRRREJXSQJR-UHFFFAOYSA-N 2h-thiazine Chemical compound N1SC=CC=C1 AGIJRRREJXSQJR-UHFFFAOYSA-N 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 title 1
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000004897 thiazines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/585,058 US4512988A (en) | 1984-03-01 | 1984-03-01 | Acylamino oxo or hydroxy substituted alkylamino thiazines and thiazepines |
| EP85102280A EP0154904B1 (de) | 1984-03-01 | 1985-02-28 | Acylamino-oxo- oder hydroxy-substituierte-alkylamino Thiazine und Thiazepine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE30429T1 true ATE30429T1 (de) | 1987-11-15 |
Family
ID=24339875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85102280T ATE30429T1 (de) | 1984-03-01 | 1985-02-28 | Acylamino-oxo- oder hydroxy-substituiertealkylamino thiazine und thiazepine. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4512988A (de) |
| EP (1) | EP0154904B1 (de) |
| JP (1) | JPH0688989B2 (de) |
| AT (1) | ATE30429T1 (de) |
| AU (1) | AU577831B2 (de) |
| CA (1) | CA1242438A (de) |
| DE (1) | DE3560831D1 (de) |
| IE (1) | IE57990B1 (de) |
| NZ (1) | NZ211264A (de) |
| ZA (1) | ZA851555B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986000618A1 (en) * | 1984-07-13 | 1986-01-30 | Takeda Chemical Industries, Ltd. | Condensed 7-membered ring compounds and process for their preparation |
| US4699905A (en) * | 1984-04-10 | 1987-10-13 | Sankyo Company, Limited | Perhydrothiazepine derivatives, their preparation and their therapeutic use |
| DE3788888T2 (de) * | 1986-04-04 | 1994-06-23 | Sankyo Co | Perhydrothiazepin- und Perhydroazepinderivate, ihre Herstellung und ihre therapeutische Verwendung. |
| US5001236A (en) * | 1989-11-22 | 1991-03-19 | Marion Laboratories, Inc. | Benzothiazepines |
| FR2756566B1 (fr) * | 1996-12-04 | 1999-01-08 | Fournier Ind & Sante | Peptides agonistes du recepteur b2 de la bradykinine, procede de preparation et utilisation en therapeutique |
| CA2410680A1 (en) * | 2000-06-30 | 2002-01-10 | Elan Pharmaceuticals, Inc. | Compounds to treat alzheimer's disease |
| PE20020276A1 (es) * | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
| US7057046B2 (en) * | 2002-05-20 | 2006-06-06 | Bristol-Myers Squibb Company | Lactam glycogen phosphorylase inhibitors and method of use |
| US7098235B2 (en) * | 2002-11-14 | 2006-08-29 | Bristol-Myers Squibb Co. | Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds |
| GB2423085C (en) * | 2005-02-11 | 2011-11-09 | Cambridge Entpr Ltd | Ligands for G-protein coupled receptors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4329473A (en) * | 1979-06-01 | 1982-05-11 | Almquist Ronald G | Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme |
| EP0068173B1 (de) * | 1981-06-05 | 1984-09-26 | Merck & Co. Inc. | Perhydro-1,4-thiazepin-5-one und Perhydro-1,4-thiazocin-5-one, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| JPS58116477A (ja) * | 1981-06-05 | 1983-07-11 | メルク・エンド・カムパニ−・インコ−ポレ−テツド | 抗高血圧剤としてのパ−ヒドロ−１，４−チアゼピン−５−オンおよびパ−ヒドロ−１，４−チアゾシン−５−オン誘導体 |
| US4470973A (en) * | 1982-07-19 | 1984-09-11 | E. R. Squibb & Sons, Inc. | Substituted peptide compounds |
| US4460579A (en) * | 1983-02-28 | 1984-07-17 | E. R. Squibb & Sons, Inc. | Thiazine and thiazepine containing compounds |
| US4564612A (en) * | 1983-04-22 | 1986-01-14 | Takeda Chemical Industries, Ltd. | Condensed, seven-membered ring compounds and their use |
| WO1986000618A1 (en) * | 1984-07-13 | 1986-01-30 | Takeda Chemical Industries, Ltd. | Condensed 7-membered ring compounds and process for their preparation |
| US4699905A (en) * | 1984-04-10 | 1987-10-13 | Sankyo Company, Limited | Perhydrothiazepine derivatives, their preparation and their therapeutic use |
-
1984
- 1984-03-01 US US06/585,058 patent/US4512988A/en not_active Expired - Fee Related
-
1985
- 1985-02-28 AU AU39255/85A patent/AU577831B2/en not_active Ceased
- 1985-02-28 IE IE498/85A patent/IE57990B1/en not_active IP Right Cessation
- 1985-02-28 ZA ZA851555A patent/ZA851555B/xx unknown
- 1985-02-28 EP EP85102280A patent/EP0154904B1/de not_active Expired
- 1985-02-28 AT AT85102280T patent/ATE30429T1/de not_active IP Right Cessation
- 1985-02-28 CA CA000475365A patent/CA1242438A/en not_active Expired
- 1985-02-28 DE DE8585102280T patent/DE3560831D1/de not_active Expired
- 1985-02-28 NZ NZ211264A patent/NZ211264A/en unknown
- 1985-03-01 JP JP60041770A patent/JPH0688989B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3560831D1 (en) | 1987-12-03 |
| AU3925585A (en) | 1985-09-12 |
| EP0154904B1 (de) | 1987-10-28 |
| IE57990B1 (en) | 1993-06-02 |
| CA1242438A (en) | 1988-09-27 |
| JPS60202870A (ja) | 1985-10-14 |
| NZ211264A (en) | 1987-11-27 |
| JPH0688989B2 (ja) | 1994-11-09 |
| AU577831B2 (en) | 1988-10-06 |
| IE850498L (en) | 1985-09-01 |
| EP0154904A1 (de) | 1985-09-18 |
| ZA851555B (en) | 1985-10-30 |
| US4512988A (en) | 1985-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |