IL52867A - Phenethylaminoalkyl isoquinolinones and benzazepinones,their preparation and pharmaceutical compositions containing same - Google Patents

Phenethylaminoalkyl isoquinolinones and benzazepinones,their preparation and pharmaceutical compositions containing same

Info

Publication number: IL52867A
Authority: IL; Israel
Prior art keywords: phenethylaminoalkyl; benzazepinones; isoquinolinones; preparation; pharmaceutical compositions
Prior art date: 1976-09-03

Application number

IL52867A

Other languages

English (en)

Other versions

IL52867A0 (en

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-03

Filing date

1977-09-01

Publication date

1980-07-31

1977-09-01 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1977-11-30 Publication of IL52867A0 publication Critical patent/IL52867A0/xx

1980-07-31 Publication of IL52867A publication Critical patent/IL52867A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Other In-Based Heterocyclic Compounds (AREA)

IL52867A 1976-09-03 1977-09-01 Phenethylaminoalkyl isoquinolinones and benzazepinones,their preparation and pharmaceutical compositions containing same IL52867A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2639718A DE2639718C2 (de)	1976-09-03	1976-09-03	1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel

Publications (2)

Publication Number	Publication Date
IL52867A0 IL52867A0 (en)	1977-11-30
IL52867A true IL52867A (en)	1980-07-31

Family

ID=5987076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL52867A IL52867A (en)	1976-09-03	1977-09-01	Phenethylaminoalkyl isoquinolinones and benzazepinones,their preparation and pharmaceutical compositions containing same

Country Status (32)

Country	Link
US (1)	US4137318A (xx)
JP (1)	JPS6026107B2 (xx)
AT (1)	AT357536B (xx)
AU (1)	AU513325B2 (xx)
BE (1)	BE858383A (xx)
BG (1)	BG31377A3 (xx)
CA (1)	CA1086726A (xx)
CS (1)	CS197300B2 (xx)
DD (1)	DD132585A5 (xx)
DE (1)	DE2639718C2 (xx)
DK (1)	DK392877A (xx)
ES (8)	ES462006A1 (xx)
FI (1)	FI63225C (xx)
FR (1)	FR2363556A1 (xx)
GB (1)	GB1548844A (xx)
GR (1)	GR63605B (xx)
HK (1)	HK54082A (xx)
IE (1)	IE45674B1 (xx)
IL (1)	IL52867A (xx)
LU (1)	LU78066A1 (xx)
MY (1)	MY8300244A (xx)
NL (1)	NL7709678A (xx)
NO (1)	NO147986C (xx)
NZ (1)	NZ185081A (xx)
PH (1)	PH16512A (xx)
PL (3)	PL112814B1 (xx)
PT (1)	PT66987B (xx)
RO (1)	RO71931A (xx)
SE (1)	SE437515B (xx)
SG (1)	SG45082G (xx)
SU (3)	SU659081A3 (xx)
ZA (1)	ZA775311B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4393210A (en) *	1980-08-28	1983-07-12	Seiyaku Co., Ltd.	1(2H)-Isoquinolone compounds and acid addition salts thereof
US4473501A (en) *	1981-05-04	1984-09-25	G. D. Searle & Co.	Dihydro azino isoquinolines
US4490369A (en) *	1981-05-19	1984-12-25	Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung	Benzazepine derivatives, their pharmaceutical compositions and method of use
DE3119874A1 (de) *	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3242599A1 (de) *	1982-11-18	1984-05-24	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3242345A1 (de) *	1982-11-16	1984-05-17	Dr. Karl Thomae Gmbh, 7950 Biberach	Verfahren zur herstellung von benzazepinderivaten
DE3343801A1 (de) *	1983-12-03	1985-06-13	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPS61158603A (ja) *	1984-12-29	1986-07-18	株式会社小糸製作所	自動車用ランプの反射鏡
JPS6220402U (xx) *	1985-07-22	1987-02-06
DE3541811A1 (de) *	1985-11-27	1987-06-04	Thomae Gmbh Dr K	Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3717561A1 (de) *	1987-05-25	1988-12-08	Thomae Gmbh Dr K	Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5175157A (en) *	1985-11-27	1992-12-29	Boehringer Ingelheim Gmbh	Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
GB8609331D0 (en) *	1986-04-16	1986-05-21	Pfizer Ltd	Anti-arrythmia agents
DE3631013A1 (de) *	1986-09-12	1988-03-24	Thomae Gmbh Dr K	Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3640641A1 (de) *	1986-11-28	1988-07-14	Thomae Gmbh Dr K	Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3736866A1 (de) *	1987-10-30	1989-05-11	Thomae Gmbh Dr K	Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz
JP2807577B2 (ja) *	1990-06-15	1998-10-08	エーザイ株式会社	環状アミド誘導体
CN101250157B (zh) *	2008-03-07	2012-03-28	西安交通大学	2-取代-3,4-二氢-1-异喹啉酮类合成方法及其制备心血管药物的用途
FR2988720B1 (fr) *	2012-03-27	2014-03-14	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3600394A (en) *	1968-05-17	1971-08-17	Searle & Co	2-aminoalkyl-3-arylisocarbostyrils
SE368009B (xx) *	1971-09-16	1974-06-17	Kabi Ab
US4021558A (en) *	1973-09-08	1977-05-03	Boehringer Ingelheim Gmbh	1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents
AT330777B (de) *	1973-09-08	1976-07-26	Thomae Gmbh Dr K	Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
CH605914A5 (xx) *	1974-07-31	1978-10-13	Ciba Geigy Ag

1976
- 1976-09-03 DE DE2639718A patent/DE2639718C2/de not_active Expired
1977
- 1977-03-29 PH PH20177A patent/PH16512A/en unknown
- 1977-07-22 FI FI772262A patent/FI63225C/fi not_active IP Right Cessation
- 1977-08-19 AT AT600477A patent/AT357536B/de not_active IP Right Cessation
- 1977-08-22 US US05/826,853 patent/US4137318A/en not_active Expired - Lifetime
- 1977-08-29 BG BG037254A patent/BG31377A3/xx unknown
- 1977-08-30 CS CS775664A patent/CS197300B2/cs unknown
- 1977-08-31 ES ES462006A patent/ES462006A1/es not_active Expired
- 1977-08-31 RO RO7791507A patent/RO71931A/ro unknown
- 1977-08-31 DD DD7700200828A patent/DD132585A5/xx unknown
- 1977-09-01 SE SE7709865A patent/SE437515B/xx not_active IP Right Cessation
- 1977-09-01 LU LU78066A patent/LU78066A1/xx unknown
- 1977-09-01 IL IL52867A patent/IL52867A/xx unknown
- 1977-09-01 FR FR7726566A patent/FR2363556A1/fr active Granted
- 1977-09-01 PT PT66987A patent/PT66987B/pt unknown
- 1977-09-02 NZ NZ185081A patent/NZ185081A/xx unknown
- 1977-09-02 PL PL1977212691A patent/PL112814B1/pl unknown
- 1977-09-02 NO NO773038A patent/NO147986C/no unknown
- 1977-09-02 BE BE180664A patent/BE858383A/xx not_active IP Right Cessation
- 1977-09-02 JP JP52105032A patent/JPS6026107B2/ja not_active Expired
- 1977-09-02 PL PL1977200630A patent/PL109757B1/pl unknown
- 1977-09-02 GR GR54280A patent/GR63605B/el unknown
- 1977-09-02 ZA ZA00775311A patent/ZA775311B/xx unknown
- 1977-09-02 PL PL1977212692A patent/PL110397B1/pl unknown
- 1977-09-02 DK DK392877A patent/DK392877A/da not_active Application Discontinuation
- 1977-09-02 NL NL7709678A patent/NL7709678A/xx not_active Application Discontinuation
- 1977-09-02 GB GB36812/77A patent/GB1548844A/en not_active Expired
- 1977-09-02 AU AU28516/77A patent/AU513325B2/en not_active Expired
- 1977-09-02 CA CA286,009A patent/CA1086726A/en not_active Expired
- 1977-09-02 SU SU772517658A patent/SU659081A3/ru active
- 1977-09-21 IE IE1831/77A patent/IE45674B1/en unknown
- 1977-12-28 ES ES465525A patent/ES465525A1/es not_active Expired
- 1977-12-28 ES ES465528A patent/ES465528A1/es not_active Expired
- 1977-12-28 ES ES465526A patent/ES465526A1/es not_active Expired
- 1977-12-28 ES ES465527A patent/ES465527A1/es not_active Expired
- 1977-12-28 ES ES465524A patent/ES465524A1/es not_active Expired
- 1977-12-28 ES ES465529A patent/ES465529A1/es not_active Expired
- 1977-12-28 ES ES465523A patent/ES465523A1/es not_active Expired
1978
- 1978-05-05 SU SU782611302A patent/SU688127A3/ru active
- 1978-05-05 SU SU782611303A patent/SU700061A3/ru active
1982
- 1982-09-13 SG SG450/82A patent/SG45082G/en unknown
- 1982-12-22 HK HK540/82A patent/HK54082A/xx unknown
1983
- 1983-12-30 MY MY244/83A patent/MY8300244A/xx unknown

Also Published As

Publication number	Publication date
ZA775311B (en)	1979-05-30
PH16512A (en)	1983-11-08
ES465525A1 (es)	1978-09-16
IE45674B1 (en)	1982-10-20
FI63225B (fi)	1983-01-31
BG31377A3 (en)	1981-12-15
JPS6026107B2 (ja)	1985-06-21
ES465524A1 (es)	1978-09-16
CA1086726A (en)	1980-09-30
NZ185081A (en)	1979-11-01
CS197300B2 (en)	1980-04-30
RO71931A (ro)	1981-11-24
DE2639718A1 (de)	1978-03-16
SU688127A3 (ru)	1979-09-25
NO147986C (no)	1983-07-20
LU78066A1 (xx)	1978-10-17
FR2363556A1 (fr)	1978-03-31
NL7709678A (nl)	1978-03-07
US4137318A (en)	1979-01-30
ES465526A1 (es)	1978-09-16
BE858383A (fr)	1978-03-02
PL110397B1 (en)	1980-07-31
PL200630A1 (pl)	1979-02-12
DK392877A (da)	1978-03-04
ATA600477A (de)	1979-12-15
IE45674L (en)	1978-03-03
FI63225C (fi)	1983-05-10
SE437515B (sv)	1985-03-04
NO147986B (no)	1983-04-11
ES465529A1 (es)	1978-09-16
PT66987A (de)	1977-10-01
JPS5331672A (en)	1978-03-25
SU659081A3 (ru)	1979-04-25
AU2851677A (en)	1979-03-08
SE7709865L (sv)	1978-03-04
IL52867A0 (en)	1977-11-30
FR2363556B1 (xx)	1981-09-11
HK54082A (en)	1982-12-31
DD132585A5 (de)	1978-10-11
GR63605B (en)	1979-11-26
PL112814B1 (en)	1980-11-29
FI772262A (fi)	1978-03-04
DE2639718C2 (de)	1987-03-05
PT66987B (de)	1979-09-12
MY8300244A (en)	1983-12-31
ES465527A1 (es)	1978-09-16
AU513325B2 (en)	1980-11-27
AT357536B (de)	1980-07-10
PL109757B1 (en)	1980-06-30
SU700061A3 (ru)	1979-11-25
NO773038L (no)	1978-03-06
ES465523A1 (es)	1978-09-16
GB1548844A (en)	1979-07-18
ES462006A1 (es)	1978-06-16
ES465528A1 (es)	1978-09-16
SG45082G (en)	1983-02-25

Publication	Publication Date	Title
IL51660A0 (en)	1977-05-31	Hentriakontapeptides their preparation and pharmaceutical compositions containing them
IL49238A (en)	1978-08-31	O-aminoethyl trifluoromethyl-phenyl-ketoximes, their preparation and pharmaceutical compositions containing them
IL51816A (en)	1981-09-13	Steroids,their preparation and pharmaceutical compositions containing them
IL53043A (en)	1982-01-31	N-heterocyclylalkyl-(1-aryloxy-2-hydroxy-3-amino-propane)derivatives,their preparation and pharmaceutical compositions containing them
IL55643A (en)	1981-12-31	Cyclopeptides,their preparation and pharmaceutical compositions containing them
IL52867A (en)	1980-07-31	Phenethylaminoalkyl isoquinolinones and benzazepinones,their preparation and pharmaceutical compositions containing same
IL50631A0 (en)	1976-12-31	1-benzazolylalkyl-4-substituted-piperidines,their preparation and pharmaceutical compositions containing them
IL49325A (en)	1979-11-30	8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them
IL51309A0 (en)	1977-03-31	New 1,2-benzisothiazolin-3-ones,their preparation and pharmaceutical compositions containing them
IL53420A (en)	1983-05-15	Oxepane derivatives,their preparation and pharmaceutical compositions containing them
IL49788A0 (en)	1976-08-31	11-desoxy-16-aryloxy-omega-pentanorprostaglandins,their preparation and pharmaceutical compositions containing them
IL52041A (en)	1980-07-31	Quinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL51812A0 (en)	1977-06-30	New isothiazolopyridine derivatives their preparation and pharmaceutical compositions containing them
IL52717A (en)	1980-12-31	Derivatives of2-phenylamino-imidazoline-(2),their preparation and pharmaceutical compositions containing them
IL52857A (en)	1983-03-31	Oxo-benzopyrane derivatives,their preparation and pharmaceutical compositions containing them
MY8000099A (en)	1980-12-31	Isobutyramides, their preparation and therapeutic compositions containing them
IL52615A (en)	1981-09-13	1-aza-prostaglandin analogues,their preparation and pharmaceutical compositions containing them
IL58648A0 (en)	1980-02-29	7-chloro-3-alkoxycarbonyl-5-haolophenyl-2-oxo-2,3-dihydro-1,4-benzo-diazepine derivatives their preparation and pharmaceutical compositions containing them
IL51468A (en)	1981-01-30	17 -hydroxy- -d-homosteroid derivatives,their preparation and pharmaceutical compositions containing them
IL53552A (en)	1981-07-31	1-piperazinopropanol esters,their preparation and pharmaceutical compositions containing them
IL53026A0 (en)	1977-11-30	New pyridobenzodiazepinones their preparation and pharmaceutical compositions containing them
IL54899A (en)	1982-05-31	Pyridazinylhydrazones,their preparation and pharmaceutical compositions containing them
IL49099A (en)	1980-09-16	Xanthene-9-carboxylates, their preparation and pharmaceutical compositions containing them
IL53342A (en)	1981-07-31	Monocyclic -lactams,their preparation and pharmaceutical compositions containing -lactams having anitbacterial activite
IL52853A (en)	1980-07-31	Phenethylaminoalkyl phthalazinones and quinoxalinones,their preparation and pharmaceutical compositions containing them