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IL133677A - Thermodynamically stable modification of 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy) ethylamino]-2- propanol, process of its preparation and pharmaceutical compositions containing it - Google Patents

Thermodynamically stable modification of 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy) ethylamino]-2- propanol, process of its preparation and pharmaceutical compositions containing it

Info

Publication number
IL133677A
IL133677A IL13367798A IL13367798A IL133677A IL 133677 A IL133677 A IL 133677A IL 13367798 A IL13367798 A IL 13367798A IL 13367798 A IL13367798 A IL 13367798A IL 133677 A IL133677 A IL 133677A
Authority
IL
Israel
Prior art keywords
carbazolyloxy
methoxyphenoxy
ethylamino
modification
thermodynamically stable
Prior art date
Application number
IL13367798A
Other languages
English (en)
Other versions
IL133677A0 (en
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of IL133677A0 publication Critical patent/IL133677A0/xx
Publication of IL133677A publication Critical patent/IL133677A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
IL13367798A 1997-07-22 1998-07-18 Thermodynamically stable modification of 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy) ethylamino]-2- propanol, process of its preparation and pharmaceutical compositions containing it IL133677A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97112491A EP0893440A1 (fr) 1997-07-22 1997-07-22 Une modification thermodynamique stabilisée de 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy)ethylamino]- 2-propanole, un procédé pour sa préparation et une composition pharmaceutique qui la contient
PCT/EP1998/004475 WO1999005105A1 (fr) 1997-07-22 1998-07-18 Modification thermodynamiquement stable de 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, son procede de preparation et compositions pharmaceutiques le contenant

Publications (2)

Publication Number Publication Date
IL133677A0 IL133677A0 (en) 2001-04-30
IL133677A true IL133677A (en) 2004-06-01

Family

ID=8227094

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13367798A IL133677A (en) 1997-07-22 1998-07-18 Thermodynamically stable modification of 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy) ethylamino]-2- propanol, process of its preparation and pharmaceutical compositions containing it

Country Status (32)

Country Link
EP (2) EP0893440A1 (fr)
JP (1) JP2001510824A (fr)
KR (1) KR100336229B1 (fr)
CN (1) CN1125047C (fr)
AR (1) AR015133A1 (fr)
AT (1) ATE236123T1 (fr)
AU (1) AU740453B2 (fr)
BR (1) BR9810776A (fr)
CA (1) CA2296637C (fr)
CZ (1) CZ296947B6 (fr)
DE (1) DE69812964T2 (fr)
DK (1) DK1000027T3 (fr)
ES (1) ES2195366T3 (fr)
HK (1) HK1029339A1 (fr)
HR (1) HRP980406A2 (fr)
HU (1) HUP0003198A3 (fr)
IL (1) IL133677A (fr)
MA (1) MA26523A1 (fr)
MY (1) MY117734A (fr)
NO (1) NO313588B1 (fr)
NZ (1) NZ502136A (fr)
PE (1) PE96999A1 (fr)
PL (1) PL191602B1 (fr)
PT (1) PT1000027E (fr)
RU (1) RU2202542C2 (fr)
SI (1) SI1000027T1 (fr)
TR (1) TR200000148T2 (fr)
TW (1) TW505631B (fr)
UY (1) UY25108A1 (fr)
WO (1) WO1999005105A1 (fr)
YU (1) YU2200A (fr)
ZA (1) ZA986475B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2402336C (fr) * 2000-04-03 2008-03-11 F. Hoffmann-La Roche Ag Solutions concentrees de carvedilol
EP1655285A1 (fr) * 2000-06-28 2006-05-10 Teva Pharmaceutical Industries Ltd. Procédé de préparation d'une forme crystalline de carvedilol (forme II)
IL153688A0 (en) 2000-06-28 2003-07-06 Teva Pharma Carvedilol
EP1406614B1 (fr) * 2001-07-13 2006-06-07 Smithkline Beecham Corporation Polymorphe de carvedilol
EP1929998A3 (fr) 2001-09-21 2008-11-26 Egalet A/S Dispersions solides à libération contrôlée de carvedilol
RU2308449C2 (ru) * 2001-09-28 2007-10-20 Ф.Хоффманн-Ля Рош Аг Псевдополиморфные формы карведилола
CN1298322C (zh) * 2002-01-15 2007-02-07 特瓦制药工业有限公司 卡维地洛的结晶固体及其制备方法
CA2483054A1 (fr) * 2002-04-30 2003-11-13 Sb Pharmco Puerto Rico Inc. Monocitrate monohydrate de carvedilol
EP1539140A4 (fr) 2002-06-27 2005-12-07 Sb Pharmco Inc Hydobromure de carvedilol
BR0312102A (pt) 2002-06-27 2007-05-29 Sb Pharmco Inc sais de fosfato de carvedilol e/ou seus solvatos, composições correspondentes, e/ou métodos de tratamento
US20040151772A1 (en) 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
DE602004031096D1 (de) 2003-03-26 2011-03-03 Egalet As Morphin-system mit kontrollierter freisetzung
WO2004094378A1 (fr) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Procede de fabrication de carvedilol, forme-ii
SI21616A (sl) * 2003-09-02 2005-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove kristalne oblike karvedilola
EP1686986A4 (fr) * 2003-11-25 2009-05-27 Sb Pharmco Inc Sels de carvedilol, compositions correspondantes, procedes d'administration et/ou de traitement
DK1838670T3 (da) * 2004-12-09 2010-03-01 Zach System Spa Fremgangsmåde til fremstilling af carvedilol og dets enantiomere
EP1781611A1 (fr) * 2005-06-09 2007-05-09 Teva Pharmaceutical Industries Ltd. Formes cristallines du carvedilol et leurs procedes de preparation
US8022094B2 (en) 2006-06-28 2011-09-20 Teva Pharmaceutical Industries Ltd. Carvedilol phosphate
US20080249317A1 (en) * 2007-04-04 2008-10-09 Apotex Inc. Novel amorphous form of carvedilol phosphate and processes for the preparation thereof
US8821928B2 (en) 2007-06-04 2014-09-02 Egalet Ltd. Controlled release pharmaceutical compositions for prolonged effect
WO2010089132A1 (fr) 2009-02-06 2010-08-12 Egalet A/S Composition à libération immédiate résistant à une maltraitance par prise d'alcool
WO2010149169A2 (fr) 2009-06-24 2010-12-29 Egalet A/S Formulations à libération contrôlée

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten

Also Published As

Publication number Publication date
YU2200A (sh) 2002-03-18
EP1000027B1 (fr) 2003-04-02
NO313588B1 (no) 2002-10-28
ES2195366T3 (es) 2003-12-01
CA2296637C (fr) 2005-11-15
ATE236123T1 (de) 2003-04-15
AR015133A1 (es) 2001-04-18
CZ2000221A3 (cs) 2000-05-17
MY117734A (en) 2004-07-31
PE96999A1 (es) 1999-10-12
BR9810776A (pt) 2000-09-19
CA2296637A1 (fr) 1999-02-04
EP0893440A1 (fr) 1999-01-27
HK1029339A1 (en) 2001-03-30
SI1000027T1 (en) 2003-10-31
HUP0003198A3 (en) 2002-10-28
DE69812964D1 (de) 2003-05-08
KR20010022097A (ko) 2001-03-15
MA26523A1 (fr) 2004-12-20
PT1000027E (pt) 2003-07-31
RU2202542C2 (ru) 2003-04-20
NO20000301L (no) 2000-01-21
NZ502136A (en) 2002-05-31
HRP980406A2 (en) 1999-04-30
JP2001510824A (ja) 2001-08-07
NO20000301D0 (no) 2000-01-21
TR200000148T2 (tr) 2000-07-21
PL338432A1 (en) 2000-11-06
CZ296947B6 (cs) 2006-08-16
AU8631998A (en) 1999-02-16
PL191602B1 (pl) 2006-06-30
DE69812964T2 (de) 2004-03-04
WO1999005105A1 (fr) 1999-02-04
TW505631B (en) 2002-10-11
DK1000027T3 (da) 2003-07-21
KR100336229B1 (ko) 2002-05-09
EP1000027A1 (fr) 2000-05-17
CN1264366A (zh) 2000-08-23
HUP0003198A2 (en) 2001-03-28
ZA986475B (en) 2000-01-21
UY25108A1 (es) 2000-12-29
AU740453B2 (en) 2001-11-01
IL133677A0 (en) 2001-04-30
CN1125047C (zh) 2003-10-22

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees