IL133677A - Thermodynamically stable modification of 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy) ethylamino]-2- propanol, process of its preparation and pharmaceutical compositions containing it - Google Patents

Thermodynamically stable modification of 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy) ethylamino]-2- propanol, process of its preparation and pharmaceutical compositions containing it

Info

Publication number: IL133677A
Authority: IL; Israel
Prior art keywords: carbazolyloxy; methoxyphenoxy; ethylamino; modification; thermodynamically stable
Prior art date: 1997-07-22

Application number

IL13367798A

Other languages

English (en)

Other versions

IL133677A0 (en

Original Assignee

Roche Diagnostics Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-22

Filing date

1998-07-18

Publication date

2004-06-01

1998-07-18 Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh

2001-04-30 Publication of IL133677A0 publication Critical patent/IL133677A0/xx

2004-06-01 Publication of IL133677A publication Critical patent/IL133677A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

IL13367798A 1997-07-22 1998-07-18 Thermodynamically stable modification of 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy) ethylamino]-2- propanol, process of its preparation and pharmaceutical compositions containing it IL133677A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97112491A EP0893440A1 (en)	1997-07-22	1997-07-22	Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
PCT/EP1998/004475 WO1999005105A1 (en)	1997-07-22	1998-07-18	Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it

Publications (2)

Publication Number	Publication Date
IL133677A0 IL133677A0 (en)	2001-04-30
IL133677A true IL133677A (en)	2004-06-01

Family

ID=8227094

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13367798A IL133677A (en)	1997-07-22	1998-07-18	Thermodynamically stable modification of 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy) ethylamino]-2- propanol, process of its preparation and pharmaceutical compositions containing it

Country Status (32)

Country	Link
EP (2)	EP0893440A1 (xx)
JP (1)	JP2001510824A (xx)
KR (1)	KR100336229B1 (xx)
CN (1)	CN1125047C (xx)
AR (1)	AR015133A1 (xx)
AT (1)	ATE236123T1 (xx)
AU (1)	AU740453B2 (xx)
BR (1)	BR9810776A (xx)
CA (1)	CA2296637C (xx)
CZ (1)	CZ296947B6 (xx)
DE (1)	DE69812964T2 (xx)
DK (1)	DK1000027T3 (xx)
ES (1)	ES2195366T3 (xx)
HK (1)	HK1029339A1 (xx)
HR (1)	HRP980406A2 (xx)
HU (1)	HUP0003198A3 (xx)
IL (1)	IL133677A (xx)
MA (1)	MA26523A1 (xx)
MY (1)	MY117734A (xx)
NO (1)	NO313588B1 (xx)
NZ (1)	NZ502136A (xx)
PE (1)	PE96999A1 (xx)
PL (1)	PL191602B1 (xx)
PT (1)	PT1000027E (xx)
RU (1)	RU2202542C2 (xx)
SI (1)	SI1000027T1 (xx)
TR (1)	TR200000148T2 (xx)
TW (1)	TW505631B (xx)
UY (1)	UY25108A1 (xx)
WO (1)	WO1999005105A1 (xx)
YU (1)	YU2200A (xx)
ZA (1)	ZA986475B (xx)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2402336C (en) *	2000-04-03	2008-03-11	F. Hoffmann-La Roche Ag	Concentrated solutions of carvedilol
EP1655285A1 (en) *	2000-06-28	2006-05-10	Teva Pharmaceutical Industries Ltd.	Method for preparation of a crystalline form of carvedilol (form II)
IL153688A0 (en)	2000-06-28	2003-07-06	Teva Pharma	Carvedilol
EP1406614B1 (en) *	2001-07-13	2006-06-07	Smithkline Beecham Corporation	Carvedilol polymorph
EP1929998A3 (en)	2001-09-21	2008-11-26	Egalet A/S	Controlled release solid dispersions of carvedilol
RU2308449C2 (ru) *	2001-09-28	2007-10-20	Ф.Хоффманн-Ля Рош Аг	Псевдополиморфные формы карведилола
CN1298322C (zh) *	2002-01-15	2007-02-07	特瓦制药工业有限公司	卡维地洛的结晶固体及其制备方法
CA2483054A1 (en) *	2002-04-30	2003-11-13	Sb Pharmco Puerto Rico Inc.	Carvedilol monocitrate monohydrate
EP1539140A4 (en)	2002-06-27	2005-12-07	Sb Pharmco Inc	CARVEDILOLHYDOBROMID
BR0312102A (pt)	2002-06-27	2007-05-29	Sb Pharmco Inc	sais de fosfato de carvedilol e/ou seus solvatos, composições correspondentes, e/ou métodos de tratamento
US20040151772A1 (en)	2002-11-08	2004-08-05	Egalet A/S	Controlled release carvedilol compositions
DE602004031096D1 (de)	2003-03-26	2011-03-03	Egalet As	Morphin-system mit kontrollierter freisetzung
WO2004094378A1 (en) *	2003-04-21	2004-11-04	Matrix Laboratories Ltd	Process for the preparation of carvedilol form-ii
SI21616A (sl) *	2003-09-02	2005-04-30	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nove kristalne oblike karvedilola
EP1686986A4 (en) *	2003-11-25	2009-05-27	Sb Pharmco Inc	CARVEDILOL SALTS, CORRESPONDING COMPOSITIONS, METHODS OF ADMINISTRATION AND / OR TREATMENT
DK1838670T3 (da) *	2004-12-09	2010-03-01	Zach System Spa	Fremgangsmåde til fremstilling af carvedilol og dets enantiomere
EP1781611A1 (en) *	2005-06-09	2007-05-09	Teva Pharmaceutical Industries Ltd.	Crystalline forms of carvedilol and processes for their preparation
US8022094B2 (en)	2006-06-28	2011-09-20	Teva Pharmaceutical Industries Ltd.	Carvedilol phosphate
US20080249317A1 (en) *	2007-04-04	2008-10-09	Apotex Inc.	Novel amorphous form of carvedilol phosphate and processes for the preparation thereof
US8821928B2 (en)	2007-06-04	2014-09-02	Egalet Ltd.	Controlled release pharmaceutical compositions for prolonged effect
WO2010089132A1 (en)	2009-02-06	2010-08-12	Egalet A/S	Immediate release composition resistant to abuse by intake of alcohol
WO2010149169A2 (en)	2009-06-24	2010-12-29	Egalet A/S	Controlled release formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2815926A1 (de) *	1978-04-13	1979-10-18	Boehringer Mannheim Gmbh	Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) *	1983-05-26	1984-11-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten

1997
- 1997-07-22 EP EP97112491A patent/EP0893440A1/en not_active Withdrawn
1998
- 1998-07-15 MY MYPI98003245A patent/MY117734A/en unknown
- 1998-07-15 PE PE1998000626A patent/PE96999A1/es not_active Application Discontinuation
- 1998-07-18 CZ CZ20000221A patent/CZ296947B6/cs not_active IP Right Cessation
- 1998-07-18 TR TR2000/00148T patent/TR200000148T2/xx unknown
- 1998-07-18 HU HU0003198A patent/HUP0003198A3/hu unknown
- 1998-07-18 DE DE69812964T patent/DE69812964T2/de not_active Expired - Fee Related
- 1998-07-18 WO PCT/EP1998/004475 patent/WO1999005105A1/en active IP Right Grant
- 1998-07-18 NZ NZ502136A patent/NZ502136A/en unknown
- 1998-07-18 JP JP2000504104A patent/JP2001510824A/ja active Pending
- 1998-07-18 SI SI9830442T patent/SI1000027T1/xx unknown
- 1998-07-18 CA CA002296637A patent/CA2296637C/en not_active Expired - Fee Related
- 1998-07-18 AU AU86319/98A patent/AU740453B2/en not_active Ceased
- 1998-07-18 IL IL13367798A patent/IL133677A/en not_active IP Right Cessation
- 1998-07-18 ES ES98937576T patent/ES2195366T3/es not_active Expired - Lifetime
- 1998-07-18 EP EP98937576A patent/EP1000027B1/en not_active Expired - Lifetime
- 1998-07-18 BR BR9810776-3A patent/BR9810776A/pt not_active Application Discontinuation
- 1998-07-18 CN CN98807436A patent/CN1125047C/zh not_active Expired - Fee Related
- 1998-07-18 YU YU2200A patent/YU2200A/sh unknown
- 1998-07-18 DK DK98937576T patent/DK1000027T3/da active
- 1998-07-18 PL PL338432A patent/PL191602B1/pl unknown
- 1998-07-18 PT PT98937576T patent/PT1000027E/pt unknown
- 1998-07-18 AT AT98937576T patent/ATE236123T1/de not_active IP Right Cessation
- 1998-07-18 RU RU2000103033/04A patent/RU2202542C2/ru not_active IP Right Cessation
- 1998-07-18 KR KR1020007000667A patent/KR100336229B1/ko not_active IP Right Cessation
- 1998-07-18 TW TW087111738A patent/TW505631B/zh not_active IP Right Cessation
- 1998-07-20 MA MA25178A patent/MA26523A1/fr unknown
- 1998-07-21 AR ARP980103547A patent/AR015133A1/es unknown
- 1998-07-21 ZA ZA9806475A patent/ZA986475B/xx unknown
- 1998-07-22 HR HR97112491.2A patent/HRP980406A2/hr not_active Application Discontinuation
- 1998-07-22 UY UY25108A patent/UY25108A1/es not_active IP Right Cessation
2000
- 2000-01-21 NO NO20000301A patent/NO313588B1/no unknown
2001
- 2001-01-02 HK HK01100012A patent/HK1029339A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
YU2200A (sh)	2002-03-18
EP1000027B1 (en)	2003-04-02
NO313588B1 (no)	2002-10-28
ES2195366T3 (es)	2003-12-01
CA2296637C (en)	2005-11-15
ATE236123T1 (de)	2003-04-15
AR015133A1 (es)	2001-04-18
CZ2000221A3 (cs)	2000-05-17
MY117734A (en)	2004-07-31
PE96999A1 (es)	1999-10-12
BR9810776A (pt)	2000-09-19
CA2296637A1 (en)	1999-02-04
EP0893440A1 (en)	1999-01-27
HK1029339A1 (en)	2001-03-30
SI1000027T1 (en)	2003-10-31
HUP0003198A3 (en)	2002-10-28
DE69812964D1 (de)	2003-05-08
KR20010022097A (ko)	2001-03-15
MA26523A1 (fr)	2004-12-20
PT1000027E (pt)	2003-07-31
RU2202542C2 (ru)	2003-04-20
NO20000301L (no)	2000-01-21
NZ502136A (en)	2002-05-31
HRP980406A2 (en)	1999-04-30
JP2001510824A (ja)	2001-08-07
NO20000301D0 (no)	2000-01-21
TR200000148T2 (tr)	2000-07-21
PL338432A1 (en)	2000-11-06
CZ296947B6 (cs)	2006-08-16
AU8631998A (en)	1999-02-16
PL191602B1 (pl)	2006-06-30
DE69812964T2 (de)	2004-03-04
WO1999005105A1 (en)	1999-02-04
TW505631B (en)	2002-10-11
DK1000027T3 (da)	2003-07-21
KR100336229B1 (ko)	2002-05-09
EP1000027A1 (en)	2000-05-17
CN1264366A (zh)	2000-08-23
HUP0003198A2 (en)	2001-03-28
ZA986475B (en)	2000-01-21
UY25108A1 (es)	2000-12-29
AU740453B2 (en)	2001-11-01
IL133677A0 (en)	2001-04-30
CN1125047C (zh)	2003-10-22

Publication	Publication Date	Title
US6730326B2 (en)	2004-05-04	Thermodynamically stable modification of 1-(4-carbazolyl-oxy-3[2-(2-methoxyphenoxy)-ethylamino]-2-propanol process for its preparation and pharmaceutical compositions containing it
EP1000027B1 (en)	2003-04-02	Thermodynamically stable modification of 1-(4-carbazolyloxy)-3- 2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
KR101468827B1 (ko)	2014-12-03	카베딜롤 인산염 및(또는) 그의 용매화물, 상응하는 조성물, 및(또는) 치료 방법
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MXPA00000507A (en)	2001-05-07	Thermodynamically stable modification of 1-(4-carbazolyloxy)-3- [2-(2-methoxyphenoxy)ethylamino]-2- propanole, process for its preparation and pharmaceutical compositions containing it
JP2001521023A (ja)	2001-11-06	ドフェチリド多形
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Legal Events

Date	Code	Title	Description
2004-11-10	FF	Patent granted
2009-08-31	MM9K	Patent not in force due to non-payment of renewal fees