IL139239A0 - 3-(amino-or aminoalkyl) pyridinone derivatives and their use for the treatment of hiv related diseases - Google Patents
3-(amino-or aminoalkyl) pyridinone derivatives and their use for the treatment of hiv related diseasesInfo
- Publication number
- IL139239A0 IL139239A0 IL13923999A IL13923999A IL139239A0 IL 139239 A0 IL139239 A0 IL 139239A0 IL 13923999 A IL13923999 A IL 13923999A IL 13923999 A IL13923999 A IL 13923999A IL 139239 A0 IL139239 A0 IL 139239A0
- Authority
- IL
- Israel
- Prior art keywords
- aminoalkyl
- amino
- treatment
- related diseases
- hiv related
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8308298P | 1998-04-27 | 1998-04-27 | |
| PCT/EP1999/003023 WO1999055676A1 (en) | 1998-04-27 | 1999-04-27 | 3-(amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of hiv related diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL139239A0 true IL139239A0 (en) | 2001-11-25 |
Family
ID=22176061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13923999A IL139239A0 (en) | 1998-04-27 | 1999-04-27 | 3-(amino-or aminoalkyl) pyridinone derivatives and their use for the treatment of hiv related diseases |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US6451822B1 (et) |
| EP (1) | EP1073637B1 (et) |
| JP (1) | JP2002513004A (et) |
| KR (1) | KR20010087128A (et) |
| CN (1) | CN1303378A (et) |
| AP (1) | AP2000001991A0 (et) |
| AT (1) | ATE334966T1 (et) |
| AU (1) | AU4137899A (et) |
| BG (1) | BG104984A (et) |
| BR (1) | BR9909976A (et) |
| CA (1) | CA2330304A1 (et) |
| CZ (1) | CZ20003978A3 (et) |
| DE (1) | DE69932611T2 (et) |
| EE (1) | EE200000620A (et) |
| HR (1) | HRP20000716A2 (et) |
| HU (1) | HUP0101595A3 (et) |
| ID (1) | ID27502A (et) |
| IL (1) | IL139239A0 (et) |
| MX (1) | MXPA00010490A (et) |
| NO (1) | NO20005387L (et) |
| NZ (1) | NZ508297A (et) |
| PL (1) | PL343685A1 (et) |
| RU (1) | RU2000129671A (et) |
| SK (1) | SK16072000A3 (et) |
| TR (1) | TR200003113T2 (et) |
| WO (1) | WO1999055676A1 (et) |
| ZA (1) | ZA200006037B (et) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436972B1 (en) * | 2000-04-10 | 2002-08-20 | Dalhousie University | Pyridones and their use as modulators of serine hydrolase enzymes |
| AU2001282938A1 (en) * | 2000-07-21 | 2002-02-05 | Elan Pharmaceuticals, Inc. | Alpha amino acid derivatives--inhibitors of leukocyte adhesion mediated by vla-4 |
| AU2002212598A1 (en) * | 2000-09-19 | 2002-04-02 | Centre National De La Recherche Scientifique (Cnrs) | Pyridinone and pyridinethione derivatives having hiv inhibiting properties |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| JP5082033B2 (ja) | 2001-12-21 | 2012-11-28 | エグゼリクシス パテント カンパニー エルエルシー | Ｌｘｒのモジュレーター |
| US7642277B2 (en) * | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| KR20050119652A (ko) * | 2003-03-24 | 2005-12-21 | 에프. 호프만-라 로슈 아게 | 역전사 효소 저해제로서의 벤질-피리다진온 |
| EP1516873A1 (en) * | 2003-09-22 | 2005-03-23 | Facultés Universitaires Notre-Dame de la Paix | 2-pyridinone derivatives, having HIV inhibiting properties |
| CN1953982B (zh) * | 2004-05-17 | 2011-07-06 | 泰博特克药品有限公司 | 4-取代-1,5-二氢-吡啶并[3,2-b]吲哚-2-酮 |
| GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| KR101238525B1 (ko) * | 2004-12-31 | 2013-02-28 | 레디 유에스 테라퓨틱스 인코포레이티드 | Ｃｅｔｐ 저해제로서의 신규 벤질아민 유도체 |
| AP2007004244A0 (en) | 2005-05-10 | 2007-12-31 | Intermune Inc | Method of modulating stress-activated protein kinase system |
| ATE548363T1 (de) | 2005-08-29 | 2012-03-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen |
| AU2006284900A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases |
| US7786120B2 (en) | 2005-08-29 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Pyridones useful as inhibitors of kinases |
| JP5237111B2 (ja) * | 2005-12-19 | 2013-07-17 | シンジェンタ リミテッド | 殺菌剤としての置換型芳香族複素環式化合物 |
| AU2008326784B2 (en) * | 2007-11-20 | 2014-04-24 | Merck Sharp & Dohme Corp. | Non-nucleoside reverse transcriptase inhibitors |
| CA3034994A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders |
| US20110184029A1 (en) * | 2008-07-14 | 2011-07-28 | Korea Research Institute Of Chemical Technology | Pyridone derivatives as non-nucleoside reverse transcriptase inhibitors |
| US8349832B2 (en) * | 2009-09-02 | 2013-01-08 | Canthera Therapeutics | Compounds and compositions for treating cancer |
| US8318737B2 (en) | 2009-09-02 | 2012-11-27 | Canthera Therapeutics Inc. | Compounds and compositions for treating cancer |
| CN102001994B (zh) * | 2010-10-22 | 2014-07-09 | 北京大学 | 吡啶酮类hiv-1逆转录酶抑制剂的制备及其应用 |
| CN103288719A (zh) * | 2012-03-05 | 2013-09-11 | 苏州欧凯医药技术有限公司 | 非核甘艾滋病毒抑制物-吡啶酮类先导体的合成 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| CN110452216B (zh) | 2014-04-02 | 2022-08-26 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
| RU2746405C2 (ru) | 2014-08-29 | 2021-04-13 | Тес Фарма С.Р.Л. | ИНГИБИТОРЫ α-АМИНО-β-КАРБОКСИМУКОНАТ-ε-СЕМИАЛЬДЕГИД-ДЕКАРБОКСИЛАЗЫ |
| SG11202106310YA (en) * | 2018-12-18 | 2021-07-29 | Merck Sharp & Dohme | Pyrimidone derivatives as selective cytotoxic agents against hiv infected cells |
| US20220242847A1 (en) * | 2019-05-22 | 2022-08-04 | Merck Sharp & Dohme Corp. | Pyridinone derivatives as selective cytotoxic agents against hiv infected cells |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308854A (en) * | 1990-06-18 | 1994-05-03 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
| IL98526A0 (en) * | 1990-06-18 | 1992-07-15 | Merck & Co Inc | Pyridones,processes for their preparation and pharmaceutical compositions containing them |
| FR2737496B1 (fr) * | 1995-07-31 | 1997-12-19 | Centre Nat Rech Scient | 4-aryl-thio-pyridin-2(1h)-ones, medicaments les contenant et leurs utilisations dans le traitement de maladies liees aux vih 1 et 2 |
-
1999
- 1999-04-27 DE DE69932611T patent/DE69932611T2/de not_active Expired - Lifetime
- 1999-04-27 ID IDW20002191A patent/ID27502A/id unknown
- 1999-04-27 HU HU0101595A patent/HUP0101595A3/hu unknown
- 1999-04-27 AP APAP/P/2000/001991A patent/AP2000001991A0/en unknown
- 1999-04-27 NZ NZ508297A patent/NZ508297A/xx unknown
- 1999-04-27 JP JP2000545836A patent/JP2002513004A/ja not_active Withdrawn
- 1999-04-27 AT AT99924870T patent/ATE334966T1/de not_active IP Right Cessation
- 1999-04-27 EP EP99924870A patent/EP1073637B1/en not_active Expired - Lifetime
- 1999-04-27 AU AU41378/99A patent/AU4137899A/en not_active Abandoned
- 1999-04-27 MX MXPA00010490A patent/MXPA00010490A/es unknown
- 1999-04-27 TR TR2000/03113T patent/TR200003113T2/xx unknown
- 1999-04-27 BR BR9909976-4A patent/BR9909976A/pt not_active IP Right Cessation
- 1999-04-27 US US09/673,635 patent/US6451822B1/en not_active Expired - Fee Related
- 1999-04-27 KR KR1020007011918A patent/KR20010087128A/ko not_active Application Discontinuation
- 1999-04-27 IL IL13923999A patent/IL139239A0/xx unknown
- 1999-04-27 SK SK1607-2000A patent/SK16072000A3/sk unknown
- 1999-04-27 PL PL99343685A patent/PL343685A1/xx unknown
- 1999-04-27 RU RU2000129671/04A patent/RU2000129671A/ru unknown
- 1999-04-27 CN CN99806829A patent/CN1303378A/zh active Pending
- 1999-04-27 CZ CZ20003978A patent/CZ20003978A3/cs unknown
- 1999-04-27 EE EEP200000620A patent/EE200000620A/et unknown
- 1999-04-27 WO PCT/EP1999/003023 patent/WO1999055676A1/en active IP Right Grant
- 1999-04-27 CA CA002330304A patent/CA2330304A1/en not_active Abandoned
-
2000
- 2000-10-23 HR HR20000716A patent/HRP20000716A2/hr not_active Application Discontinuation
- 2000-10-25 ZA ZA200006037A patent/ZA200006037B/en unknown
- 2000-10-26 NO NO20005387A patent/NO20005387L/no not_active Application Discontinuation
- 2000-11-24 BG BG104984A patent/BG104984A/xx unknown
-
2002
- 2002-07-15 US US10/194,240 patent/US6683079B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL343685A1 (en) | 2001-08-27 |
| ID27502A (id) | 2001-04-12 |
| DE69932611D1 (de) | 2006-09-14 |
| RU2000129671A (ru) | 2004-02-20 |
| AU4137899A (en) | 1999-11-16 |
| CA2330304A1 (en) | 1999-11-04 |
| KR20010087128A (ko) | 2001-09-15 |
| CN1303378A (zh) | 2001-07-11 |
| NZ508297A (en) | 2002-12-20 |
| EP1073637A1 (en) | 2001-02-07 |
| DE69932611T2 (de) | 2007-10-11 |
| BR9909976A (pt) | 2000-12-26 |
| NO20005387L (no) | 2000-12-04 |
| TR200003113T2 (tr) | 2001-05-21 |
| US6451822B1 (en) | 2002-09-17 |
| US6683079B2 (en) | 2004-01-27 |
| NO20005387D0 (no) | 2000-10-26 |
| US20030125340A1 (en) | 2003-07-03 |
| HUP0101595A3 (en) | 2002-12-28 |
| EP1073637B1 (en) | 2006-08-02 |
| HUP0101595A2 (hu) | 2001-11-28 |
| AP2000001991A0 (en) | 2000-12-31 |
| CZ20003978A3 (cs) | 2001-09-12 |
| MXPA00010490A (es) | 2002-10-17 |
| WO1999055676A1 (en) | 1999-11-04 |
| EE200000620A (et) | 2002-04-15 |
| JP2002513004A (ja) | 2002-05-08 |
| ZA200006037B (en) | 2002-01-25 |
| BG104984A (en) | 2001-07-31 |
| SK16072000A3 (sk) | 2002-04-04 |
| ATE334966T1 (de) | 2006-08-15 |
| HRP20000716A2 (en) | 2001-06-30 |
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