[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

IL138930A0 - Il-17 homologies polypeptides and therapeutic uses thereof - Google Patents

Il-17 homologies polypeptides and therapeutic uses thereof

Info

Publication number
IL138930A0
IL138930A0 IL13893099A IL13893099A IL138930A0 IL 138930 A0 IL138930 A0 IL 138930A0 IL 13893099 A IL13893099 A IL 13893099A IL 13893099 A IL13893099 A IL 13893099A IL 138930 A0 IL138930 A0 IL 138930A0
Authority
IL
Israel
Prior art keywords
polypeptides
present
homologies
nucleic acid
therapeutic uses
Prior art date
Application number
IL13893099A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26772882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL138930(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL138930A0 publication Critical patent/IL138930A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL13893099A 1998-05-15 1999-05-14 Il-17 homologies polypeptides and therapeutic uses thereof IL138930A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8557998P 1998-05-15 1998-05-15
US11362198P 1998-12-23 1998-12-23
PCT/US1999/010733 WO1999060127A2 (en) 1998-05-15 1999-05-14 Il-17 homologous polypeptides and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
IL138930A0 true IL138930A0 (en) 2001-11-25

Family

ID=26772882

Family Applications (3)

Application Number Title Priority Date Filing Date
IL13893099A IL138930A0 (en) 1998-05-15 1999-05-14 Il-17 homologies polypeptides and therapeutic uses thereof
IL138930A IL138930A (en) 1998-05-15 2000-10-06 Homologous C17-IL polypeptides and their use in medicine
IL193149A IL193149A (en) 1998-05-15 2008-07-31 Anti il-17c antibody and therapeutic compositions comprising same

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL138930A IL138930A (en) 1998-05-15 2000-10-06 Homologous C17-IL polypeptides and their use in medicine
IL193149A IL193149A (en) 1998-05-15 2008-07-31 Anti il-17c antibody and therapeutic compositions comprising same

Country Status (14)

Country Link
US (6) US7217412B2 (de)
EP (2) EP2333069A3 (de)
JP (1) JP3577586B2 (de)
AT (1) ATE365800T1 (de)
AU (1) AU740405B2 (de)
CA (1) CA2328496C (de)
CY (1) CY1106885T1 (de)
DE (1) DE69936382T3 (de)
DK (1) DK1076703T4 (de)
ES (1) ES2292242T5 (de)
IL (3) IL138930A0 (de)
NZ (1) NZ508878A (de)
PT (1) PT1076703E (de)
WO (1) WO1999060127A2 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
US8212004B2 (en) 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
US6579520B2 (en) * 1998-05-15 2003-06-17 Genentech, Inc. IL-17 related mammalian cytokine polypeptides (IL-17E)
US6562578B1 (en) 1999-01-11 2003-05-13 Schering Corporation IL-17-like cytokine binding compounds and antibodies
EP3112468A1 (de) * 1998-05-15 2017-01-04 Genentech, Inc. Il-17-homologe polypeptide und therapeutische verwendung davon
US7771719B1 (en) 2000-01-11 2010-08-10 Genentech, Inc. Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E
JP3577586B2 (ja) 1998-05-15 2004-10-13 ジェネンテック・インコーポレーテッド Ｉｌ−１７相同的ポリペプチドとその治療用途
US20050147609A1 (en) * 1998-05-15 2005-07-07 Genentech, Inc. Use of anti-IL-17 antibody for the treatment of cartilage damaged by osteoarthritis
AU4208799A (en) * 1998-05-29 1999-12-13 Human Genome Sciences, Inc. Interleukins-21 and 22
US20010023070A1 (en) * 1998-05-29 2001-09-20 Reinhard Ebner Interleukins-21 and 22
AU6277799A (en) * 1998-10-02 2000-04-26 Eli Lilly And Company Il-17 homolog nucleic acids, polypeptides, vectors, host cells, methods and usesthereof
IL143600A0 (en) * 1999-01-11 2002-04-21 Schering Corp Interleukin-17 related mammalian cytokines, polynucleotides encoding them and their uses
AU3207000A (en) * 1999-01-11 2000-08-01 Schering Corporation Interleukin-17 related mammalian cytokine (il-171). polynucleotides encoding them. uses
EP1169445A2 (de) * 1999-04-09 2002-01-09 Curagen Corporation Menschliche proteins und dafür kodierende polynukleotide
EP1897946B1 (de) * 1999-12-23 2012-07-11 Genentech, Inc. IL-17-homologe Polypeptide und ihre therapeutische Verwendung
US20040043397A1 (en) 2000-01-11 2004-03-04 Genentech, Inc. IL-17 homologous polypeptides and therapeutic uses thereof
EP1240325B1 (de) * 1999-12-23 2009-09-30 Genentech, Inc. Il-17 und il-17r homologe polypeptide und deren therapeutische verwendungen
JP2016047051A (ja) * 1999-12-23 2016-04-07 ジェネンテック， インコーポレイテッド Ｉｌ−１７相同的ポリペプチドとその治療上の用途
MXPA02007674A (es) * 2000-02-08 2002-12-13 Amgen Inc Moleculas similares a interlucina-17 y uso de las mismas.
US20030203451A1 (en) * 2000-08-24 2003-10-30 Genentech, Inc. IL-17 homologous polypeptides and therapeutic uses thereof
US7718397B2 (en) 2000-03-21 2010-05-18 Genentech, Inc. Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof
WO2001079288A2 (en) 2000-04-18 2001-10-25 Schering Corporation Cytokine uses; compositions; methods
US20030096969A1 (en) 2000-06-02 2003-05-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
ATE494304T1 (de) 2000-06-16 2011-01-15 Human Genome Sciences Inc Immunspezifisch bindende antikörper gegen blys
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
US20060083713A1 (en) * 2000-10-13 2006-04-20 Eli Lilly And Company Methods of using a human il-17 related polypeptide to treat disease
US6793919B2 (en) * 2000-10-18 2004-09-21 Immunex Corporation Methods for treating rheumatoid arthritis using IL-17 antagonists
AU2002225714A1 (en) * 2000-11-10 2002-05-21 The Regents Of The University Of California Il-17 receptor-like protein, uses thereof, and modulation of catabolic activity of il-17 cytokines on bone and cartilage
AU2002242142A1 (en) * 2001-02-09 2002-08-28 Johns Hopkins University A cytokine related structurally to il-17
AU2002305053A1 (en) * 2001-03-26 2002-10-08 University Of Washington Method of inducing proliferation of retinal stem cells
MXPA06012754A (es) 2004-05-03 2007-02-19 Schering Corp El uso de la expresion de il-17 para predecir la inflamacion de la piel: metodos de tratamiento.
US20050287593A1 (en) 2004-05-03 2005-12-29 Schering Corporation Use of cytokine expression to predict skin inflammation; methods of treatment
EP1765865A2 (de) * 2004-06-10 2007-03-28 ZymoGenetics, Inc. Löslicher zcytor14, anti-zcytor14-antikörper und bindepartner sowie verfahren zur anwendung bei entzündungen
EP1612892B1 (de) * 2004-06-30 2008-03-19 Tyco Electronics Nederland B.V. Verbinder für elektronische Bauteile
GB0417487D0 (en) 2004-08-05 2004-09-08 Novartis Ag Organic compound
EP2322553A3 (de) * 2005-02-14 2011-11-16 Wyeth LLC Interleukin-17FAntikörper und andere Antagonisten der IL-17F Signalübertragung sowie deren Verwendungen
PL1931697T3 (pl) * 2005-09-28 2011-03-31 Zymogenetics Inc Antagoniści interleukiny IL-17A i IL-17F oraz sposoby ich zastosowania
US7467467B2 (en) 2005-09-30 2008-12-23 Pratt & Whitney Canada Corp. Method for manufacturing a foam core heat exchanger
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
US8211649B2 (en) 2006-03-31 2012-07-03 Human Genome Sciences, Inc. Methods of diagnosing and prognosing hodgkin's lymphoma
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
CA2679588A1 (en) 2007-03-26 2008-10-02 Zymogenetics, Inc. Soluble il-17ra/rc fusion proteins and related methods
CA2684329A1 (en) * 2007-04-20 2008-10-30 Amgen Inc. Identification and method for using the pre-ligand assembly domain of the il-17 receptor
WO2009136286A2 (en) 2008-05-05 2009-11-12 Novimmune Sa Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
KR101811886B1 (ko) 2009-05-05 2017-12-22 노비뮨 에스 에이 항―ｉｌ―17ｆ 항체 및 이의 사용 방법
CN102821787B (zh) 2010-01-15 2015-07-29 麒麟-安姆根有限公司 抗体制剂和治疗方案
CA2842067A1 (en) * 2011-07-19 2013-01-24 The National Institute For Biotechnology In The Negev, Ltd. Novel il-17r-ecd mutants
EP2768859B1 (de) 2011-10-19 2018-02-21 MorphoSys AG Il17c-antagonisten zur behandlung von entzündungskrankheiten
US20140274068A1 (en) * 2013-03-15 2014-09-18 Herbert DAWID Mobile terminal and method for determining a receive window
JP2017511810A (ja) * 2014-02-11 2017-04-27 ビン ワーン 免疫療法組成物、治療方法、及び診断方法
US20170342147A1 (en) * 2014-12-15 2017-11-30 Morphosys Ag Antibodies for IL-17C
EP3359161A1 (de) 2015-10-05 2018-08-15 MorphoSys AG Antagonisten von il-17c zur behandlung und/oder prävention von atopischer dermatitis
PL3416983T3 (pl) * 2016-02-19 2021-10-25 Morphosys Ag Przeciwciała dla il-17c
JP7186094B2 (ja) 2016-05-06 2022-12-08 イグジキュア オペレーティング カンパニー インターロイキン１７受容体ｍＲＮＡの特異的ノックダウンのためのアンチセンスオリゴヌクレオチド（ＡＳＯ）を提示するリポソーム系球状核酸（ＳＮＡ）構築物
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
US20230203149A1 (en) 2017-09-25 2023-06-29 Morphosys Ag Treatment of atopic dermatitis
GB201803563D0 (en) 2018-03-06 2018-04-18 Galapagos Nv Antibodies and pharmaceutical compositions thereof for the treatment of autoimmune skin diseases
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
US20220348682A1 (en) 2018-08-30 2022-11-03 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
CN116286665A (zh) * 2018-11-16 2023-06-23 上海煦顼技术有限公司 嵌合抗原受体细胞分泌治疗剂
AU2019384145A1 (en) * 2018-11-20 2021-06-10 Innovative Cellular Therapeutics Holdings, Ltd. Modified cell expressing therapeutic agent and uses thereof
US10918667B2 (en) 2018-11-20 2021-02-16 Innovative Cellular Therapeutics CO., LTD. Modified cell expressing therapeutic agent and uses thereof
US12076343B2 (en) 2020-02-19 2024-09-03 Innovative Cellular Therapeutics Holdings, Ltd. Engineered safety in cell therapy
US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer
KR102718110B1 (ko) * 2021-10-01 2024-10-17 (주)케어젠 탈모 방지 또는 발모 촉진 활성을 갖는 펩타이드와 이의 용도
CN114410477B (zh) * 2021-11-29 2023-10-10 深圳大学 一种诱导型no合成酶的抑制剂及其生产菌株和制备方法

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
WO1981001145A1 (en) 1979-10-18 1981-04-30 Univ Illinois Hydrolytic enzyme-activatible pro-drugs
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4943529A (en) 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
AU3145184A (en) 1983-08-16 1985-02-21 Zymogenetics Inc. High expression of foreign genes in schizosaccharomyces pombe
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
EP0272253A4 (de) 1986-03-07 1990-02-05 Massachusetts Inst Technology Verfahren zur verbesserung der glykoproteinstabilität.
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US4946783A (en) 1987-01-30 1990-08-07 President And Fellows Of Harvard College Periplasmic protease mutants of Escherichia coli
GB8705477D0 (en) 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US5010182A (en) 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
GB8724885D0 (en) 1987-10-23 1987-11-25 Binns M M Fowlpox virus promotors
US5169770A (en) 1987-12-21 1992-12-08 The University Of Toledo Agrobacterium mediated transformation of germinating plant seeds
AU4005289A (en) 1988-08-25 1990-03-01 Smithkline Beecham Corporation Recombinant saccharomyces
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5009772A (en) 1989-02-27 1991-04-23 Kerr-Mcgee Corporation Solvent extraction process
ES2055907T3 (es) 1989-03-07 1994-09-01 Genentech Inc Conjugados covalentes de lipidos y oligonucleotidos.
ES2038579T3 (es) 1989-04-28 1997-02-16 Rhein Biotech Proz & Prod Gmbh Celulas de levadura del genero schwanniomyces.
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
JPH04505261A (ja) 1989-05-10 1992-09-17 スローン―ケツテリング・インステイテユート・フオー・キヤンサー・リサーチ ポルｉｉｉプロモーターの制御下の転写可能な外来ｄｎａを含む安定的に形質転換された真核細胞
EP0402226A1 (de) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformationsvektoren für Hefe Yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
ATE144793T1 (de) 1989-06-29 1996-11-15 Medarex Inc Bispezifische reagenzien für die aids-therapie
FR2649120B1 (fr) 1989-06-30 1994-01-28 Cayla Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
WO1991004753A1 (en) 1989-10-02 1991-04-18 Cetus Corporation Conjugates of antisense oligonucleotides and therapeutic uses thereof
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
EP0498843B1 (de) 1989-10-24 1996-06-12 Gilead Sciences, Inc. Oligonukleotidanaloga mit neuartigen bindungen
US5190750A (en) * 1990-03-09 1993-03-02 Asahi Kasei Kogyo Kabushiki Kaisha Methods for the treatment of demyelinating disease, uveitis, or graft-versus-host disease using tnf
JPH03276071A (ja) 1990-03-27 1991-12-06 Yoshiomi Kondo 流体及び電磁流体の物理量予測方法
US5385915A (en) 1990-05-16 1995-01-31 The Rockefeller University Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DK0814159T3 (da) 1990-08-29 2005-10-24 Genpharm Int Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
EP0586505A1 (de) 1991-05-14 1994-03-16 Repligen Corporation Heterokonjugat-antikörper zur behandlung von hiv-infektionen
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
EP0617706B1 (de) 1991-11-25 2001-10-17 Enzon, Inc. Multivalente antigen-bindende proteine
GB9214857D0 (en) 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
EP0672141B1 (de) 1992-10-23 2003-05-14 Immunex Corporation Methoden zur herstellung löslicher, oligomerer proteine
RU2139731C1 (ru) 1992-11-13 1999-10-20 Айдек Фармасьютикалс Корпорейшн (US Способ лечения, антитела, гибридома
JPH08503950A (ja) 1992-12-02 1996-04-30 アルカーメス・コントロールド・セラピユーテイクス・インコーポレーテツド 徐放性成長ホルモン含有マイクロスフェア
US5536637A (en) 1993-04-07 1996-07-16 Genetics Institute, Inc. Method of screening for cDNA encoding novel secreted mammalian proteins in yeast
US6562333B1 (en) 1993-06-14 2003-05-13 Schering Corporation Purified mammalian CTLA-8 antigens and related reagents
WO2000073452A2 (en) 1999-06-02 2000-12-07 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
CN1157562A (zh) 1994-09-09 1997-08-20 武田药品工业株式会社 含有一种肽金属盐的缓释制剂
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
DK0817847T4 (da) 1995-03-23 2009-10-05 Immunex Corp IL-17-receptor
WO1996040072A2 (en) 1995-06-07 1996-12-19 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of human growth hormone
ZA965368B (en) 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
CA2227220A1 (en) 1995-07-19 1997-02-06 Genetics Institute, Inc. Human ctla-8 and uses of ctla-8-related proteins
US6074849A (en) 1995-07-19 2000-06-13 Genetics Institute, Inc. Polynucleotides encoding human CTLA-8 related proteins
WO1997033551A2 (en) 1996-03-15 1997-09-18 Millennium Pharmaceuticals Compositions and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation
WO1999046281A2 (en) 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
WO2000070050A1 (en) 1999-05-14 2000-11-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2000053752A2 (en) 1999-03-08 2000-09-14 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
CN1258315A (zh) * 1997-04-25 2000-06-28 津莫吉尼蒂克斯公司 哺乳动物细胞因子样因子7
JP2001510035A (ja) * 1997-07-16 2001-07-31 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド インターロイキン−２０
EP1015488B1 (de) 1997-09-17 2009-09-09 Human Genome Sciences, Inc. Interleukin-17 rezeptor-ähnliches protein
US6562578B1 (en) * 1999-01-11 2003-05-13 Schering Corporation IL-17-like cytokine binding compounds and antibodies
AU2004799A (en) * 1997-12-19 1999-07-12 Millennium Biotherapeutics, Inc. Novel embryo-derived interleukin related factor molecules and uses therefor
AU2031399A (en) * 1998-01-09 1999-07-26 Immunex Corporation Human and murine il-17d, cytokine related to interleukin-17: dna and polypeptides
NZ528703A (en) 1998-03-25 2005-05-27 Genentech Inc Novel PRO337 polypeptides and nucleic acids encoding a neurotrimin polypeptide
JP3577586B2 (ja) 1998-05-15 2004-10-13 ジェネンテック・インコーポレーテッド Ｉｌ−１７相同的ポリペプチドとその治療用途
AU4208799A (en) * 1998-05-29 1999-12-13 Human Genome Sciences, Inc. Interleukins-21 and 22
US20010023070A1 (en) * 1998-05-29 2001-09-20 Reinhard Ebner Interleukins-21 and 22
EP1443055A3 (de) * 1998-05-29 2005-06-08 Human Genome Sciences, Inc. Interleukine-21 und 22
AU6050499A (en) 1998-09-17 2000-04-03 Zymogenetics Inc. Mammalian transforming growth factor beta - 9 (ztgfss9)
AU6277799A (en) * 1998-10-02 2000-04-26 Eli Lilly And Company Il-17 homolog nucleic acids, polypeptides, vectors, host cells, methods and usesthereof
WO2001054477A2 (en) 2000-01-25 2001-08-02 Hyseq, Inc. Novel nucleic acids and polypeptides
AU6069800A (en) 1999-07-07 2001-01-30 Zymogenetics Inc. Human cytokine receptor
CA2380355A1 (en) 1999-09-01 2001-03-08 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1240325B1 (de) 1999-12-23 2009-09-30 Genentech, Inc. Il-17 und il-17r homologe polypeptide und deren therapeutische verwendungen
US20040034192A1 (en) 2000-01-06 2004-02-19 Seishi Kato Human proteins having hyprophobic domains and dnas encoding these proteins
CA2395654A1 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001057202A2 (en) 2000-02-04 2001-08-09 The Board Of Trustees Of The University Of Arkansas Evi27 gene sequences and protein encoded thereby
AU6802801A (en) 2000-03-01 2001-09-24 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
AR030554A1 (es) 2000-03-16 2003-08-27 Amgen Inc Moleculas similares a receptores il-17 y usos de las mismas
CA2403370A1 (en) 2000-03-16 2001-09-15 Amgen Inc. Il-17 receptor like molecules and uses thereof
EP1303604A2 (de) 2000-05-24 2003-04-23 Schering Corporation Rezeptorproteine aus säugetieren; verwandte reagenzien und verfahren
ES2444710T3 (es) 2000-06-22 2014-02-26 Amgen, Inc. Uso de un anticuerpo específico para un polipéptido similar a IL-17
JP2004506413A (ja) 2000-06-23 2004-03-04 ジェネンテック・インコーポレーテッド 血管形成に関与する疾患の診断と治療のための組成物と方法
AU2001271973A1 (en) 2000-07-20 2002-02-05 Kevin P. Baker Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
WO2002008259A2 (en) 2000-07-26 2002-01-31 Zymogenetics, Inc. Human cytokine receptor
US20060083713A1 (en) * 2000-10-13 2006-04-20 Eli Lilly And Company Methods of using a human il-17 related polypeptide to treat disease
MXPA04001187A (es) 2001-08-07 2004-07-08 Immunex Corp Receptores de interleucina-1 en el tratamiento de enfermedades.
ATE439166T1 (de) 2002-10-30 2009-08-15 Genentech Inc Hemmung von il-17 produktion
MXPA05013881A (es) 2003-06-23 2008-02-13 Genetics Inst Llc Anticuerpos contra interleucina-22 y usos de los mismos.
ES2751414T5 (es) 2003-07-08 2024-04-23 Novartis Pharma Ag Anticuerpos antagonistas a polipéptidos heterólogos IL-17 A/F
AU2006255686A1 (en) * 2005-06-06 2006-12-14 Genentech, Inc. Transgenic models for different genes and their use for gene characterization

Also Published As

Publication number Publication date
EP1076703A2 (de) 2001-02-21
CA2328496A1 (en) 1999-11-25
CY1106885T1 (el) 2012-09-26
WO1999060127A3 (en) 2000-01-27
DK1076703T4 (da) 2011-03-28
WO1999060127A9 (en) 2000-03-30
US7749500B2 (en) 2010-07-06
PT1076703E (pt) 2007-10-10
US20090022725A1 (en) 2009-01-22
DE69936382T2 (de) 2008-03-06
CA2328496C (en) 2016-01-05
DK1076703T3 (da) 2007-10-22
US20060205038A1 (en) 2006-09-14
EP2333069A2 (de) 2011-06-15
US20020052027A1 (en) 2002-05-02
US7115398B2 (en) 2006-10-03
NZ508878A (en) 2003-08-29
DE69936382D1 (de) 2007-08-09
ES2292242T3 (es) 2008-03-01
US8075888B2 (en) 2011-12-13
WO1999060127A2 (en) 1999-11-25
IL193149A (en) 2010-12-30
JP3577586B2 (ja) 2004-10-13
JP2002515246A (ja) 2002-05-28
EP1076703B2 (de) 2010-12-15
US20020106743A1 (en) 2002-08-08
EP1076703B1 (de) 2007-06-27
IL193149A0 (en) 2009-02-11
US7217412B2 (en) 2007-05-15
DE69936382T3 (de) 2011-07-07
US20120128627A1 (en) 2012-05-24
IL138930A (en) 2008-12-29
AU3993799A (en) 1999-12-06
AU740405B2 (en) 2001-11-01
US20110038868A1 (en) 2011-02-17
EP2333069A3 (de) 2011-09-14
ATE365800T1 (de) 2007-07-15
ES2292242T5 (es) 2011-05-04

Similar Documents

Publication Publication Date Title
IL138930A0 (en) Il-17 homologies polypeptides and therapeutic uses thereof
HK1150856A1 (en) Il-17 homologous polypeptide and therapeutic uses thereof il-17
ATE447583T1 (de) Polypeptide und dafür kodierende nukleinsäure
DE69832539D1 (de) Polypeptid und dafür kodierendes Nukeinsäure
KR100515858B1 (en) PRO617 Polypeptides
KR100515855B1 (en) PRO351 Polypeptides
KR100515856B1 (en) PRO618 Polypeptides
KR100515857B1 (en) PRO792 Polypeptides
ATE415422T1 (de) Menschliches gas-6 (growth arrest-specific gene 6) protein und dafür kodierende nukleinsäuren
EP1865061A3 (de) IL-17-homologe Polypeptide und ihre therapeutische Verwendung
PT1241180E (pt) Proteína semelhante a antigénio a33 humano e ácido nucleico que a codifica
PT1241183E (pt) Proteína semelhante a hcar humana e ácidos nucleicos que a codificam
PT1241184E (pt) Proteína semelhante a sinaptogirina e ácidos nucleicos que a codificam
DE69829230D1 (de) Polypeptid und dafür kodieredes Nukleinsäure
DE69827532D1 (de) Polypeptide und dafür kodierende Nukleinsäure
EP1241185A3 (de) Menschliches Protocadherin-ähnliches Protein und dafür kodierende Nukleinsäure
ATE268819T1 (de) Pro241 polypeptide und dafür kodierende nukleinsäuren