IL107158A0 - Quaternary basic amides,their preparation and pharmaceuticcal compositions containing them - Google Patents

Quaternary basic amides,their preparation and pharmaceuticcal compositions containing them

Info

Publication number: IL107158A0
Authority: IL; Israel
Prior art keywords: group; alkyl; preparation; pharmaceuticcal; omega
Prior art date: 1992-09-30

Application number

IL107158A

Other languages

English (en)

Original Assignee

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-30

Filing date

1993-09-29

Publication date

1993-12-28

1993-09-29 Application filed by Sanofi Elf filed Critical Sanofi Elf

1993-12-28 Publication of IL107158A0 publication Critical patent/IL107158A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Indole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Inorganic Compounds Of Heavy Metals (AREA)

IL107158A 1992-09-30 1993-09-29 Quaternary basic amides,their preparation and pharmaceuticcal compositions containing them IL107158A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9212083A FR2696178B1 (fr)	1992-09-30	1992-09-30	Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant.

Publications (1)

Publication Number	Publication Date
IL107158A0 true IL107158A0 (en)	1993-12-28

Family

ID=9434374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL107158A IL107158A0 (en)	1992-09-30	1993-09-29	Quaternary basic amides,their preparation and pharmaceuticcal compositions containing them

Country Status (27)

Country	Link
EP (1)	EP0591040B1 (ja)
JP (2)	JP2857041B2 (ja)
KR (1)	KR100279084B1 (ja)
CN (1)	CN1036652C (ja)
AT (1)	ATE176469T1 (ja)
AU (1)	AU674875B2 (ja)
BR (1)	BR9303982A (ja)
CA (1)	CA2107432C (ja)
CZ (1)	CZ287272B6 (ja)
DE (1)	DE69323375T2 (ja)
DK (1)	DK0591040T3 (ja)
ES (1)	ES2130238T3 (ja)
FI (1)	FI114474B (ja)
FR (1)	FR2696178B1 (ja)
GR (1)	GR3030000T3 (ja)
HU (2)	HU215848B (ja)
IL (1)	IL107158A0 (ja)
MX (1)	MX9306024A (ja)
MY (1)	MY108881A (ja)
NO (1)	NO304888B1 (ja)
NZ (1)	NZ248821A (ja)
OA (1)	OA09869A (ja)
RU (1)	RU2120436C1 (ja)
SG (1)	SG47807A1 (ja)
SI (1)	SI9300513B (ja)
TW (1)	TW242625B (ja)
ZA (1)	ZA937276B (ja)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5583134A (en) *	1992-09-30	1996-12-10	Sanofi	1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
FR2717802B1 (fr) *	1994-03-25	1996-06-21	Sanofi Sa	Nouveaux composés aromatiques, procédé pour leur préparation et compositions pharmaceutiques en contenant.
FR2717804B1 (fr) *	1994-03-25	1996-06-21	Sanofi Sa	Sels de composés hétéroaromatiques azotés substitués, procédé pour leur préparation et compositions pharmaceutiques en contenant.
NZ270985A (en)	1994-04-29	1997-06-24	Lilly Co Eli	Substituted benzimidazole derivatives; medicaments and preparation of medicaments
NZ289652A (en)	1994-07-12	1998-05-27	Lilly Co Eli	(r)-3-(1h-indol-3-yl)-1-[n-(2-methoxybenzyl)acetylamino]-2-[n-(2-(4-( piperidin-1-yl)piperidin-1-yl)acetyl)amino]propane dihydrochloride trihydrate; non-peptidyl tachykinin receptor antagonistic medicaments
FR2725900B1 (fr) *	1994-10-21	1997-07-18	Sanofi Sa	Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
US6008223A (en) *	1994-10-27	1999-12-28	Zeneca Limited	Therapeutic compounds
GB9421709D0 (en) *	1994-10-27	1994-12-14	Zeneca Ltd	Therapeutic compounds
EP0714891A1 (en) *	1994-11-22	1996-06-05	Eli Lilly And Company	Heterocyclic tachykinin receptor antagonists
FR2729954B1 (fr) *	1995-01-30	1997-08-01	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729951B1 (fr) *	1995-01-30	1997-04-18	Sanofi Sa	Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2729952B1 (fr) *	1995-01-30	1997-04-18	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2751654B1 (fr) *	1996-07-26	1998-10-23	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
US5654316A (en) *	1995-06-06	1997-08-05	Schering Corporation	Piperidine derivatives as neurokinin antagonists
ES2191755T3 (es) *	1995-06-06	2003-09-16	Schering Corp	Compuestos heterociclicos bencenofusionados sustituidos como antagonistas de la neuroquinina.
FR2745811B1 (fr) *	1996-03-07	1998-05-22	Sanofi Sa	Glutarimide disubstitue procede pour sa preparation, et son utilisation
AU3149297A (en) *	1996-05-24	1997-12-09	Eli Lilly And Company	Methods of treating hypertension
US5691362A (en) *	1996-06-05	1997-11-25	Schering-Plough Corporation	Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
GB9617730D0 (en) *	1996-08-23	1996-10-02	Pfizer Ltd	Quarternary ammonium compounds
FR2759585B1 (fr) *	1997-02-17	1999-06-11	Sanofi Sa	Formulations pharmaceutiques presentees sous forme seche pour l'administration orale d'un compose ammonium quaternaire cyclique
FR2759584B1 (fr) *	1997-02-17	1999-06-11	Sanofi Sa	Composition pharmaceutique pour l'administration orale de composes heterocycliques sous forme ammonium quaternaire
JP2001524960A (ja) *	1997-04-24	2001-12-04	メルクシヤープエンドドームリミテツド	摂食障害を治療するためのｎｋ−１受容体拮抗薬の使用
GB9712882D0 (en) *	1997-06-18	1997-08-20	Pfizer Ltd	Quaternary ammonium compounds
GB9716457D0 (en) *	1997-08-04	1997-10-08	Merck Sharp & Dohme	Therapeutic agents
GB9716463D0 (en) *	1997-08-04	1997-10-08	Merck Sharp & Dohme	Therapeutic agents
CA2298779A1 (en) *	1997-08-04	1999-02-18	Merck Sharp & Dohme Limited	Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
CA2298777A1 (en) *	1997-08-04	1999-02-18	Merck Sharp & Dohme Limited	Use of nk-1 receptor antagonists for treating mania
GB9816897D0 (en) *	1998-08-04	1998-09-30	Merck Sharp & Dohme	Therapeutic use
GB9927125D0 (en)	1999-11-16	2000-01-12	Univ Reading The	Placental human neurokinin B precursor
CN1942441A (zh)	2004-02-25	2007-04-04	三共株式会社	磺酰氧基衍生物
WO2006102308A2 (en)	2005-03-22	2006-09-28	Azevan Pharmaceuticals, Inc.	Beta-lactamyl vasopressin v1b antagonists
PL1910346T3 (pl)	2005-07-19	2019-09-30	Azevan Pharmaceuticals, Inc.	Beta-laktamowy antagonista wazopresyny fenyloalaniny, cysteiny i seryny
WO2008090117A1 (en)	2007-01-24	2008-07-31	Glaxo Group Limited	Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
CN107007596A (zh)	2010-07-01	2017-08-04	阿泽凡药物公司	用于治疗创伤后应激障碍的方法
MX2021005502A (es)	2014-03-28	2023-01-16	Azevan Pharmaceuticals Inc	Composiciones y metodos para tratar enfermedades neurodegenerativas.
MY196804A (en) *	2016-12-14	2023-05-03	Beijing Showby Pharmaceutical Co Ltd	Class of bifunctional compounds with quaternary ammonium salt structure
EP3681871A4 (en)	2017-09-15	2021-05-26	Azevan Pharmaceuticals, Inc.	COMPOSITIONS AND METHODS OF TREATMENT OF BRAIN INJURY

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI97540C (fi) *	1989-11-06	1997-01-10	Sanofi Sa	Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
FR2666185B1 (fr) *	1990-08-21	1992-12-04	Sgs Thomson Microelectronics	Convertisseur analogique/numerique a interpolation.
IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical preparations containing them

1992
- 1992-09-30 FR FR9212083A patent/FR2696178B1/fr not_active Expired - Fee Related
1993
- 1993-09-13 TW TW082107498A patent/TW242625B/zh active
- 1993-09-28 DE DE69323375T patent/DE69323375T2/de not_active Expired - Fee Related
- 1993-09-28 DK DK93402362T patent/DK0591040T3/da active
- 1993-09-28 EP EP93402362A patent/EP0591040B1/fr not_active Expired - Lifetime
- 1993-09-28 SG SG1996004468A patent/SG47807A1/en unknown
- 1993-09-28 AT AT93402362T patent/ATE176469T1/de not_active IP Right Cessation
- 1993-09-28 ES ES93402362T patent/ES2130238T3/es not_active Expired - Lifetime
- 1993-09-28 KR KR1019930020216A patent/KR100279084B1/ko not_active IP Right Cessation
- 1993-09-29 NO NO933481A patent/NO304888B1/no not_active IP Right Cessation
- 1993-09-29 FI FI934273A patent/FI114474B/fi active IP Right Grant
- 1993-09-29 IL IL107158A patent/IL107158A0/xx not_active IP Right Cessation
- 1993-09-29 CZ CZ19932035A patent/CZ287272B6/cs not_active IP Right Cessation
- 1993-09-29 CN CN93118177A patent/CN1036652C/zh not_active Expired - Fee Related
- 1993-09-29 RU RU93055131/04A patent/RU2120436C1/ru not_active IP Right Cessation
- 1993-09-29 OA OA60420A patent/OA09869A/fr unknown
- 1993-09-29 MY MYPI93001979A patent/MY108881A/en unknown
- 1993-09-29 MX MX9306024A patent/MX9306024A/es not_active IP Right Cessation
- 1993-09-30 BR BR9303982A patent/BR9303982A/pt not_active Application Discontinuation
- 1993-09-30 ZA ZA937276A patent/ZA937276B/xx unknown
- 1993-09-30 JP JP5268295A patent/JP2857041B2/ja not_active Expired - Fee Related
- 1993-09-30 HU HUP9302770A patent/HU215848B/hu not_active IP Right Cessation
- 1993-09-30 NZ NZ248821A patent/NZ248821A/en not_active IP Right Cessation
- 1993-09-30 SI SI9300513A patent/SI9300513B/sl not_active IP Right Cessation
- 1993-09-30 CA CA002107432A patent/CA2107432C/en not_active Expired - Fee Related
- 1993-09-30 AU AU48708/93A patent/AU674875B2/en not_active Ceased
1995
- 1995-06-28 HU HU95P/P00518P patent/HU211889A9/hu unknown
1997
- 1997-12-25 JP JP35863297A patent/JP3243212B2/ja not_active Expired - Fee Related
1999
- 1999-04-20 GR GR990401079T patent/GR3030000T3/el unknown

Also Published As

Publication number	Publication date
NO933481L (no)	1994-04-05
HUT65759A (en)	1994-07-28
ATE176469T1 (de)	1999-02-15
FR2696178B1 (fr)	1994-12-30
NO933481D0 (no)	1993-09-29
FR2696178A1 (fr)	1994-04-01
CN1036652C (zh)	1997-12-10
CZ287272B6 (en)	2000-10-11
EP0591040A1 (fr)	1994-04-06
DE69323375T2 (de)	1999-06-24
HU215848B (hu)	1999-04-28
ES2130238T3 (es)	1999-07-01
SI9300513A (en)	1994-06-30
KR940007026A (ko)	1994-04-26
CA2107432C (en)	2000-04-04
AU4870893A (en)	1994-04-14
DE69323375D1 (de)	1999-03-18
CN1088582A (zh)	1994-06-29
JP2857041B2 (ja)	1999-02-10
JPH10175976A (ja)	1998-06-30
NZ248821A (en)	1995-10-26
SI9300513B (sl)	2002-02-28
HU211889A9 (en)	1995-12-28
EP0591040B1 (fr)	1999-02-03
MX9306024A (es)	1994-03-31
OA09869A (fr)	1994-08-15
RU2120436C1 (ru)	1998-10-20
DK0591040T3 (da)	1999-09-20
BR9303982A (pt)	1994-10-25
KR100279084B1 (ko)	2001-01-15
FI934273A (fi)	1994-03-31
MY108881A (en)	1996-11-30
SG47807A1 (en)	1998-04-17
FI114474B (fi)	2004-10-29
CA2107432A1 (en)	1994-03-31
JP3243212B2 (ja)	2002-01-07
NO304888B1 (no)	1999-03-01
TW242625B (ja)	1995-03-11
CZ203593A3 (en)	1994-04-13
GR3030000T3 (en)	1999-07-30
HU9302770D0 (en)	1993-12-28
JPH06211850A (ja)	1994-08-02
FI934273A0 (fi)	1993-09-29
AU674875B2 (en)	1997-01-16
ZA937276B (en)	1994-04-25

Publication	Publication Date	Title
IL107158A0 (en)	1993-12-28	Quaternary basic amides,their preparation and pharmaceuticcal compositions containing them
RU93055131A (ru)	1996-04-27	Четвертичные амиды основного характера, способ их получения и содержащая их фармацевтическая композиция
IL99022A0 (en)	1992-07-15	Compositions containing cyclodextrin complexes for neuraxial administration of drugs
IL101567A0 (en)	1992-12-30	Pharmaceutical compositions containing a nitrosating compound
WO1990004918A3 (en)	1990-08-09	Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
GB8900408D0 (en)	1989-03-08	Compositions for inhibiting glucan synthesis
SG64368A1 (en)	1999-04-27	Dermorphin analogs their methods of preparation pharmaceutical compositions and methods of therapeutic treatment using the same
IL103510A0 (en)	1993-03-15	Pharmaceutical compositions containing antibodies for causing immunosuppression
IT1150213B (it)	1986-12-10	Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche
IE893653L (en)	1990-05-14	Compositions and compounds
DE3269309D1 (en)	1986-04-03	Pyrrolo(2,3-d)carbazole derivatives, preparation thereof and their therapeutical use
IL87168A0 (en)	1988-12-30	Pharmaceutical compositions containing somatotrophin releasing factor
GB2251617B (en)	1995-02-01	Pharmaceutical compositions containing substituted 3-hydroxypyridin-4-ones
IE872578L (en)	1988-03-26	Antigestagen compositions
ZA893517B (en)	1991-01-30	Peptide-drug compositions containing alpha-aminoboronic acid derivatives
IL106080A (en)	1997-06-10	Pharmaceutical compositions containing amidinoalkane-1, 1-bisphosphonic acids and some such novel compounds
IL87444A0 (en)	1989-01-31	Pharmaceutical compositions containing polyaromatic compounds
ZA922252B (en)	1993-09-27	Bis-Naphthalimides containing amino acid derived linkers as anticancer agents
IL83392A0 (en)	1987-12-31	Pharmaceutical compositions containing polyaromatic compounds
IL86096A0 (en)	1988-11-15	Extended release pharmaceutical compositions containing cholinergic amines
IL85265A0 (en)	1988-07-31	Pharmaceutical compositions containing polyaromatic compounds

Legal Events

Date	Code	Title
1997-03-18	FF	Patent granted
1997-07-13	KB	Patent renewed
1997-11-20	HP	Change in proprietorship
2000-01-31	KB	Patent renewed
2002-02-10	HC	Change of name of proprietor(s)
2003-12-10	KB	Patent renewed
2007-10-31	KB	Patent renewed
2012-10-31	MM9K	Patent not in force due to non-payment of renewal fees