HUS2100006I1 - Avapritinib és gyógyászatilag elfogadható sói - Google Patents
Avapritinib és gyógyászatilag elfogadható sóiInfo
- Publication number
- HUS2100006I1 HUS2100006I1 HUS2100006C HUS2100006C HUS2100006I1 HU S2100006 I1 HUS2100006 I1 HU S2100006I1 HU S2100006 C HUS2100006 C HU S2100006C HU S2100006 C HUS2100006 C HU S2100006C HU S2100006 I1 HUS2100006 I1 HU S2100006I1
- Authority
- HU
- Hungary
- Prior art keywords
- avapritinib
- pharmaceutically acceptable
- acceptable salts
- salts
- pharmaceutically
- Prior art date
Links
- DWYRIWUZIJHQKQ-SANMLTNESA-N (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine Chemical compound Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 DWYRIWUZIJHQKQ-SANMLTNESA-N 0.000 title 1
- 229950009576 avapritinib Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Jellies, Jams, And Syrups (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361892086P | 2013-10-17 | 2013-10-17 | |
| US201461931204P | 2014-01-24 | 2014-01-24 | |
| US201461975229P | 2014-04-04 | 2014-04-04 | |
| EP14799576.5A EP3057969B1 (en) | 2013-10-17 | 2014-10-15 | Compositions useful for treating disorders related to kit |
| PCT/US2014/060746 WO2015057873A1 (en) | 2013-10-17 | 2014-10-15 | Compositions useful for treating disorders related to kit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUS2100006I1 true HUS2100006I1 (hu) | 2021-03-29 |
Family
ID=51904226
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE14799576A HUE039687T2 (hu) | 2013-10-17 | 2014-10-15 | Kompozíciók, amelyek alkalmazhatók KIT-tel kapcsolatos rendellenességek kezelésében való alkalmazásra |
| HUE18170264A HUE059041T2 (hu) | 2013-10-17 | 2014-10-15 | Eljárás KIT-tel összefüggõ rendellenességek kezelésére alkalmas kompozíciók elõállítására |
| HUS2100006C HUS2100006I1 (hu) | 2013-10-17 | 2021-03-03 | Avapritinib és gyógyászatilag elfogadható sói |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE14799576A HUE039687T2 (hu) | 2013-10-17 | 2014-10-15 | Kompozíciók, amelyek alkalmazhatók KIT-tel kapcsolatos rendellenességek kezelésében való alkalmazásra |
| HUE18170264A HUE059041T2 (hu) | 2013-10-17 | 2014-10-15 | Eljárás KIT-tel összefüggõ rendellenességek kezelésére alkalmas kompozíciók elõállítására |
Country Status (30)
| Country | Link |
|---|---|
| US (7) | US9200002B2 (hu) |
| EP (2) | EP3057969B1 (hu) |
| JP (2) | JP6446040B2 (hu) |
| KR (1) | KR102378689B1 (hu) |
| CN (2) | CN105658652B (hu) |
| AU (1) | AU2014337314B2 (hu) |
| BR (1) | BR112016008541B1 (hu) |
| CA (1) | CA2926999C (hu) |
| CY (2) | CY1121182T1 (hu) |
| DK (1) | DK3057969T3 (hu) |
| ES (2) | ES2923888T3 (hu) |
| HK (1) | HK1221461A1 (hu) |
| HR (1) | HRP20181388T1 (hu) |
| HU (3) | HUE039687T2 (hu) |
| IL (1) | IL244677B (hu) |
| LT (2) | LT3057969T (hu) |
| MX (1) | MX365614B (hu) |
| NL (1) | NL301094I2 (hu) |
| NO (1) | NO2021012I1 (hu) |
| PH (1) | PH12016500611A1 (hu) |
| PL (2) | PL3057969T3 (hu) |
| PT (2) | PT3057969T (hu) |
| RS (1) | RS57542B1 (hu) |
| RU (1) | RU2706235C2 (hu) |
| SG (1) | SG11201602937UA (hu) |
| SI (1) | SI3057969T1 (hu) |
| TW (1) | TWI683814B (hu) |
| UY (1) | UY35787A (hu) |
| WO (1) | WO2015057873A1 (hu) |
| ZA (1) | ZA201601970B (hu) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| BR112015000653A2 (pt) | 2012-07-11 | 2019-11-05 | Blueprint Medicines Corp | compostos inibidores do receptor de fator de crescimento de fibroblasto, sua composição farmacêutica e seus usos |
| MY181020A (en) | 2013-03-15 | 2020-12-16 | Sanofi Sa | Heteroaryl compounds and uses thereof |
| WO2014160521A1 (en) | 2013-03-15 | 2014-10-02 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| FR3008779B1 (fr) | 2013-07-19 | 2018-01-26 | Areva Np | Barre antivibratoire pour faisceau de tubes d'un generateur de vapeur |
| US9334263B2 (en) | 2013-10-17 | 2016-05-10 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| SG11201602937UA (en) | 2013-10-17 | 2016-05-30 | Blueprint Medicines Corp | Compositions useful for treating disorders related to kit |
| EP3060560A1 (en) | 2013-10-25 | 2016-08-31 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| MA38393B1 (fr) | 2014-03-13 | 2018-11-30 | Sanofi Sa | Composés hétéroaryle et utilisations associées |
| US9944664B2 (en) | 2014-04-15 | 2018-04-17 | Dow Agrosciences Llc | Metalloenzyme inhibitor compounds as fungicides |
| US9688680B2 (en) | 2014-08-04 | 2017-06-27 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| WO2017004134A1 (en) * | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| MX2018000577A (es) | 2015-07-16 | 2018-09-05 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la ret quinasa. |
| MX2018001032A (es) | 2015-07-24 | 2018-11-09 | Blueprint Medicines Corp | Compuestos utiles para el tratamiento de trastornos relacionados con kit y pdgfr. |
| EP3341374A1 (en) | 2015-08-26 | 2018-07-04 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| KR20180102544A (ko) | 2015-10-26 | 2018-09-17 | 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 | Trk 억제제-내성 암에서의 점 돌연변이 및 이의 관련 방법 |
| HUE064659T2 (hu) | 2015-11-02 | 2024-04-28 | Blueprint Medicines Corp | RET inhibitorai |
| AR106756A1 (es) | 2015-11-19 | 2018-02-14 | Blueprint Medicines Corp | Compuestos y composiciones útiles para el tratamiento de trastornos relacionados con ntrk |
| WO2017161269A1 (en) | 2016-03-17 | 2017-09-21 | Blueprint Medicines Corporation | Inhibitors of ret receptor tyrosine kinases |
| CA3019671C (en) | 2016-04-04 | 2024-02-20 | Loxo Oncology, Inc. | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| SG11201808676RA (en) | 2016-04-04 | 2018-11-29 | Loxo Oncology Inc | Methods of treating pediatric cancers |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| WO2017181117A1 (en) * | 2016-04-15 | 2017-10-19 | Blueprint Medicines Corporation | Inhibitors of activin receptor-like kinase |
| DK3458456T3 (da) | 2016-05-18 | 2020-12-14 | Array Biopharma Inc | Fremstilling af (s)-n-(5-((r)-2-(2,5-difluorphenyl)pyrrolidin-1-yl)pyrazol[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamid |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| US10035789B2 (en) * | 2016-07-27 | 2018-07-31 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| ES2948194T3 (es) | 2017-01-18 | 2023-09-01 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]pirazina sustituida como inhibidores de la cinasa RET |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| WO2018183712A1 (en) * | 2017-03-31 | 2018-10-04 | Blueprint Medicines Corporation | Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr |
| TW202410896A (zh) | 2017-10-10 | 2024-03-16 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| WO2019079649A1 (en) | 2017-10-18 | 2019-04-25 | Blueprint Medicines Corporation | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF ACTIVIN RECEPTOR-RELATED KINASE |
| CN108191874B (zh) * | 2018-01-16 | 2019-11-29 | 成都施贝康生物医药科技有限公司 | 一种C-Kit抑制剂及其应用 |
| EP3740490A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| EP4353317A3 (en) | 2018-04-03 | 2024-05-08 | Blueprint Medicines Corporation | Ret inhibitor for use in treating cancer having a ret alteration |
| CN109970745B (zh) * | 2018-04-16 | 2020-12-08 | 深圳市塔吉瑞生物医药有限公司 | 取代的吡咯并三嗪类化合物及其药物组合物及其用途 |
| US20210205782A1 (en) | 2018-06-22 | 2021-07-08 | Comercializadora Innvento S.A. | Multilayer absorbent filtering item comprising a first layer of a porous activated carbon support disposed on a nonwoven polyester-fibre felt, a second layer of a polymer film and a third layer of an active ingredient; method for obtaining said item; and use of same |
| CA3224949A1 (en) | 2018-07-31 | 2020-02-06 | Loxo Oncology, Inc. | Spray-dried dispersions, formulations, and polymorphs of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1h-pyrazole-4-carboxamide |
| US11964988B2 (en) | 2018-09-10 | 2024-04-23 | Array Biopharma Inc. | Fused heterocyclic compounds as RET kinase inhibitors |
| TW202039862A (zh) | 2018-11-12 | 2020-11-01 | 美商藍印藥品公司 | 受體酪氨酸激酶(kit)基因突變 |
| CN109232583A (zh) * | 2018-11-29 | 2019-01-18 | 尚科生物医药（上海）有限公司 | 一种6-溴-3H-吡咯并[2,1-f][1,2,4]三嗪-4-酮的制备方法 |
| JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物 |
| US20220041579A1 (en) | 2018-12-19 | 2022-02-10 | Array Biopharma Inc. | Substituted quinoxaline compounds as inhibitors of fgfr tyrosine kinases |
| CN111410648B (zh) * | 2019-01-07 | 2024-03-29 | 浙江海正药业股份有限公司 | 一种手性c-KIT抑制剂药物关键中间体及其制备方法 |
| SG11202111244XA (en) | 2019-04-12 | 2021-11-29 | Blueprint Medicines Corp | Pyrrolotriazine derivatives for treating kit- and pdgfra-mediated diseases |
| PT3856341T (pt) | 2019-04-12 | 2023-12-12 | Blueprint Medicines Corp | Formas cristalinas de (s)-1-(4-fluorofenil)-1-(2-(4-(6-(1- metil-1h-pirazol-4-il)pirrolo[2,1-f][1,2,4]triazin-4- il)piperazinil)pirimidin-5-il)etan-1-amina e métodos de preparação |
| CN114341138A (zh) * | 2019-07-09 | 2022-04-12 | 桑多斯股份公司 | 口服可用的选择性kit和pdgfr激酶抑制剂的晶型 |
| US20240075041A1 (en) * | 2019-10-04 | 2024-03-07 | Blueprint Medicines Corporation | Treatment of eosinophilic disorders with avapritinib |
| GB201915447D0 (en) * | 2019-10-24 | 2019-12-11 | Johnson Matthey Plc | Polymorphs of avapritinib and methods of preparing the polymorphs |
| US20220370465A1 (en) | 2019-11-04 | 2022-11-24 | Blueprint Medicines Corporation | Treatment of mast cell diseases and eosinophilic disorders |
| EP4069369A4 (en) | 2019-12-06 | 2024-02-14 | Schrödinger, Inc. | CYCLIC COMPOUNDS AND METHODS OF USE THEREOF |
| CN110950872A (zh) * | 2019-12-25 | 2020-04-03 | 武汉九州钰民医药科技有限公司 | 制备靶向抗癌药avapritinib的方法 |
| CN110938077B (zh) * | 2019-12-25 | 2021-04-27 | 武汉九州钰民医药科技有限公司 | 合成Avapritinib的方法 |
| BR112022012684A2 (pt) | 2019-12-27 | 2023-03-07 | Schroedinger Inc | Compostos cíclicos e métodos de uso dos mesmos |
| EP4118084A1 (en) | 2020-03-11 | 2023-01-18 | Teva Czech Industries s.r.o. | Solid state forms of avapritinib and process for preparation thereof |
| WO2021257522A1 (en) | 2020-06-17 | 2021-12-23 | Teva Czech Industries S.R.O | Solid state forms of avapritinib salts |
| JP2023537470A (ja) | 2020-08-03 | 2023-09-01 | ヤンセン バイオテツク，インコーポレーテツド | ウイルス治療における多方向バイオ輸送のための材料及び方法 |
| EP4211140A1 (en) | 2020-09-10 | 2023-07-19 | Schrödinger, Inc. | Heterocyclic pericondensed cdc7 kinase inhibitors for the treatment of cancer |
| CN117098760A (zh) | 2020-10-14 | 2023-11-21 | 缆图药品公司 | 用于治疗kit和pdgfra介导的疾病的组合物和方法 |
| US20230391780A1 (en) | 2020-10-14 | 2023-12-07 | Blueprint Medicines Corporation | Compositions and methods for treating kit- and pdgfra-mediated diseases |
| CN112552339A (zh) * | 2020-12-10 | 2021-03-26 | 安徽昊帆生物有限公司 | 一种o-二苯基磷酰羟胺的制备方法 |
| US20240148732A1 (en) | 2021-01-26 | 2024-05-09 | Schrödinger, Inc. | Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders |
| HU231413B1 (hu) * | 2021-02-26 | 2023-08-28 | Egis Gyógyszergyár Zrt. | Eljárás avapritinib és intermedierek előállítására |
| TW202300150A (zh) | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
| CN113278023B (zh) * | 2021-07-22 | 2021-10-15 | 上海睿跃生物科技有限公司 | 含氮杂环化合物及其制备方法和应用 |
| CN113686987B (zh) * | 2021-08-19 | 2022-04-26 | 海南医学院 | 一种用于检测Avapritinib中间体中对映异构体的方法 |
| CA3237696A1 (en) | 2021-11-08 | 2023-05-11 | Progentos Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
| AR129089A1 (es) * | 2022-04-19 | 2024-07-17 | Blueprint Medicines Corp | Inhibidores de kit |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59120985A (ja) * | 1982-12-28 | 1984-07-12 | 株式会社 鷺宮製作所 | サ−マルアクチユエ−タ− |
| JPS61238784A (ja) | 1985-04-17 | 1986-10-24 | Sumitomo Seiyaku Kk | コハク酸イミド誘導体及びその酸付加塩 |
| US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| ES2258459T3 (es) * | 1999-05-21 | 2006-09-01 | Bristol-Myers Squibb Company | Pirrolotriazinas inhibidoras de quinasas. |
| MXPA02003436A (es) | 1999-10-07 | 2002-08-20 | Amgen Inc | Inhibidores de triazina cinasa. |
| US6784603B2 (en) * | 2001-07-20 | 2004-08-31 | Teledyne Lighting And Display Products, Inc. | Fluorescent lighting apparatus |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| CN1662509A (zh) | 2002-04-23 | 2005-08-31 | 布里斯托尔-迈尔斯斯奎布公司 | 可用作激酶抑制剂的吡咯并三嗪苯胺化合物 |
| TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| DE602004029145D1 (de) | 2003-02-27 | 2010-10-28 | Palau Pharma Sa | Pyrazolopyridin-derivate |
| AU2005249380C1 (en) * | 2004-04-23 | 2012-09-20 | Exelixis, Inc. | Kinase modulators and methods of use |
| EP1755607A2 (en) | 2004-04-29 | 2007-02-28 | Pharmix Corporation | Compositions and treatments for inhibiting kinase and/or hmg-coa reductase |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US20050288290A1 (en) * | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| ES2401099T3 (es) * | 2005-11-02 | 2013-04-16 | Bayer Intellectual Property Gmbh | Pirrolo[2,1-F] [1,2,4]-triazin-4-ilaminas como inhibidores de la quinasa IGF-1R para el tratamiento del cáncer y de otras enfermedades hiperproliferativas |
| US7348325B2 (en) * | 2005-11-30 | 2008-03-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| CN101007814A (zh) * | 2006-01-27 | 2007-08-01 | 上海恒瑞医药有限公司 | 吡咯并六元杂环化合物及其在医药上的用途 |
| DK1973910T3 (da) * | 2006-01-27 | 2013-08-12 | Shanghai Hengrui Pharm Co Ltd | Pyrrolo[3,2-c]pyridin-4-on-2-indolinon-proteinkinaseinhibitorer |
| PT2041138E (pt) | 2006-07-07 | 2014-10-07 | Bristol Myers Squibb Co | Inibidores de pirrolotriazina quinase |
| AU2008279097B2 (en) | 2007-07-25 | 2013-05-02 | Bristol-Myers Squibb Company | Triazine kinase inhibitors |
| MX2010010151A (es) | 2008-03-20 | 2010-10-25 | Amgen Inc | Moduladores de cinasa aurora y metodo de uso. |
| KR20100003912A (ko) | 2008-07-02 | 2010-01-12 | 삼성전자주식회사 | 동일 포맷의 미디어 파일 간에 미디어 정보 호환이 가능한미디어 파일을 생성하는 방법 및 장치와 미디어 파일을실행하는 방법 및 장치 |
| WO2010022055A2 (en) | 2008-08-20 | 2010-02-25 | Amgen Inc. | Inhibitors of voltage-gated sodium channels |
| US20130023497A1 (en) | 2009-06-08 | 2013-01-24 | Chunlin Tao | Triazine Derivatives and their Therapeutical Applications |
| ES2706185T3 (es) | 2009-07-07 | 2019-03-27 | Mei Pharma Inc | Pirimidinil y 1,3,5-triazinil bencimidazoles y sus usos en la terapia contra el cáncer |
| US9334269B2 (en) | 2010-02-17 | 2016-05-10 | Amgen Inc. | Carboxamides as inhibitors of voltage-gated sodium channels |
| WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| CN102040494A (zh) | 2010-11-12 | 2011-05-04 | 西北师范大学 | 对氟苯甲醛的制备方法 |
| AU2011346670B2 (en) * | 2010-12-23 | 2015-05-07 | Pfizer Inc. | Glucagon receptor modulators |
| BR112015000653A2 (pt) | 2012-07-11 | 2019-11-05 | Blueprint Medicines Corp | compostos inibidores do receptor de fator de crescimento de fibroblasto, sua composição farmacêutica e seus usos |
| ES2889757T3 (es) | 2012-09-06 | 2022-01-13 | Plexxikon Inc | Compuestos y procedimientos para la modulación de quinasas e indicaciones para estos |
| PT2935248T (pt) | 2012-12-21 | 2018-04-05 | Plexxikon Inc | Compostos e métodos para a modulação de quinase e indicações associadas |
| TWI629266B (zh) | 2012-12-28 | 2018-07-11 | 藍印藥品公司 | 纖維母細胞生長因子受體之抑制劑 |
| WO2014160521A1 (en) | 2013-03-15 | 2014-10-02 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
| SG11201602937UA (en) | 2013-10-17 | 2016-05-30 | Blueprint Medicines Corp | Compositions useful for treating disorders related to kit |
| US9334263B2 (en) | 2013-10-17 | 2016-05-10 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| EP3060560A1 (en) | 2013-10-25 | 2016-08-31 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| US9688680B2 (en) | 2014-08-04 | 2017-06-27 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| MX2018001032A (es) | 2015-07-24 | 2018-11-09 | Blueprint Medicines Corp | Compuestos utiles para el tratamiento de trastornos relacionados con kit y pdgfr. |
| EP3341374A1 (en) | 2015-08-26 | 2018-07-04 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| HUE064659T2 (hu) | 2015-11-02 | 2024-04-28 | Blueprint Medicines Corp | RET inhibitorai |
| AR106756A1 (es) | 2015-11-19 | 2018-02-14 | Blueprint Medicines Corp | Compuestos y composiciones útiles para el tratamiento de trastornos relacionados con ntrk |
| WO2017161269A1 (en) | 2016-03-17 | 2017-09-21 | Blueprint Medicines Corporation | Inhibitors of ret receptor tyrosine kinases |
| WO2017181117A1 (en) | 2016-04-15 | 2017-10-19 | Blueprint Medicines Corporation | Inhibitors of activin receptor-like kinase |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| US10035789B2 (en) | 2016-07-27 | 2018-07-31 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| US20190192522A1 (en) | 2016-09-08 | 2019-06-27 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor 4 in combination with cyclin-dependent kinase inhibitors |
| WO2018183712A1 (en) | 2017-03-31 | 2018-10-04 | Blueprint Medicines Corporation | Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr |
| CN109400610A (zh) | 2017-08-18 | 2019-03-01 | 浙江海正药业股份有限公司 | 吡咯并三嗪类衍生物、其制备方法及其在医药上的用途 |
| CN108191874B (zh) | 2018-01-16 | 2019-11-29 | 成都施贝康生物医药科技有限公司 | 一种C-Kit抑制剂及其应用 |
| TW202039862A (zh) | 2018-11-12 | 2020-11-01 | 美商藍印藥品公司 | 受體酪氨酸激酶(kit)基因突變 |
| PT3856341T (pt) | 2019-04-12 | 2023-12-12 | Blueprint Medicines Corp | Formas cristalinas de (s)-1-(4-fluorofenil)-1-(2-(4-(6-(1- metil-1h-pirazol-4-il)pirrolo[2,1-f][1,2,4]triazin-4- il)piperazinil)pirimidin-5-il)etan-1-amina e métodos de preparação |
| CN110950872A (zh) | 2019-12-25 | 2020-04-03 | 武汉九州钰民医药科技有限公司 | 制备靶向抗癌药avapritinib的方法 |
| CN110938077B (zh) | 2019-12-25 | 2021-04-27 | 武汉九州钰民医药科技有限公司 | 合成Avapritinib的方法 |
-
2014
- 2014-10-15 SG SG11201602937UA patent/SG11201602937UA/en unknown
- 2014-10-15 AU AU2014337314A patent/AU2014337314B2/en active Active
- 2014-10-15 CN CN201480056950.4A patent/CN105658652B/zh active Active
- 2014-10-15 ES ES18170264T patent/ES2923888T3/es active Active
- 2014-10-15 RU RU2016118768A patent/RU2706235C2/ru active
- 2014-10-15 HU HUE14799576A patent/HUE039687T2/hu unknown
- 2014-10-15 HU HUE18170264A patent/HUE059041T2/hu unknown
- 2014-10-15 PT PT147995765T patent/PT3057969T/pt unknown
- 2014-10-15 RS RS20180915A patent/RS57542B1/sr unknown
- 2014-10-15 CA CA2926999A patent/CA2926999C/en active Active
- 2014-10-15 BR BR112016008541-8A patent/BR112016008541B1/pt active IP Right Grant
- 2014-10-15 EP EP14799576.5A patent/EP3057969B1/en active Active
- 2014-10-15 ES ES14799576.5T patent/ES2683127T3/es active Active
- 2014-10-15 WO PCT/US2014/060746 patent/WO2015057873A1/en active Application Filing
- 2014-10-15 EP EP18170264.8A patent/EP3409674B1/en active Active
- 2014-10-15 JP JP2016523939A patent/JP6446040B2/ja active Active
- 2014-10-15 MX MX2016004927A patent/MX365614B/es active IP Right Grant
- 2014-10-15 US US14/515,327 patent/US9200002B2/en active Active
- 2014-10-15 SI SI201430841T patent/SI3057969T1/sl unknown
- 2014-10-15 PL PL14799576T patent/PL3057969T3/pl unknown
- 2014-10-15 PT PT181702648T patent/PT3409674T/pt unknown
- 2014-10-15 KR KR1020167012391A patent/KR102378689B1/ko active IP Right Grant
- 2014-10-15 LT LTEP14799576.5T patent/LT3057969T/lt unknown
- 2014-10-15 DK DK14799576.5T patent/DK3057969T3/en active
- 2014-10-15 PL PL18170264.8T patent/PL3409674T3/pl unknown
- 2014-10-15 CN CN201910192873.XA patent/CN110003217B/zh active Active
- 2014-10-16 UY UY0001035787A patent/UY35787A/es active IP Right Grant
- 2014-10-16 TW TW103135888A patent/TWI683814B/zh active
-
2015
- 2015-10-20 US US14/887,614 patent/US9994575B2/en active Active
-
2016
- 2016-03-17 IL IL24467716A patent/IL244677B/en active IP Right Grant
- 2016-03-22 ZA ZA2016/01970A patent/ZA201601970B/en unknown
- 2016-04-05 PH PH12016500611A patent/PH12016500611A1/en unknown
- 2016-08-10 HK HK16109506.0A patent/HK1221461A1/zh unknown
-
2017
- 2017-04-04 US US15/479,145 patent/US9944651B2/en active Active
-
2018
- 2018-05-07 US US15/973,378 patent/US10807985B2/en active Active
- 2018-08-21 CY CY20181100868T patent/CY1121182T1/el unknown
- 2018-08-28 HR HRP20181388TT patent/HRP20181388T1/hr unknown
- 2018-11-30 JP JP2018224481A patent/JP6782756B2/ja active Active
-
2020
- 2020-10-14 US US17/070,556 patent/US20210284645A1/en not_active Abandoned
-
2021
- 2021-03-03 HU HUS2100006C patent/HUS2100006I1/hu unknown
- 2021-03-03 NL NL301094C patent/NL301094I2/nl unknown
- 2021-03-11 CY CY2021007C patent/CY2021007I2/el unknown
- 2021-03-16 LT LTPA2021003C patent/LTC3057969I2/lt unknown
- 2021-03-18 NO NO2021012C patent/NO2021012I1/no unknown
-
2022
- 2022-11-09 US US17/983,747 patent/US11827642B2/en active Active
-
2023
- 2023-10-23 US US18/382,727 patent/US20240317757A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUS2100006I1 (hu) | Avapritinib és gyógyászatilag elfogadható sói | |
| HRP20180684T1 (hr) | Kombinacija lijekova | |
| HRP20180635T1 (hr) | Pirazolamidni spoj i njegova upotreba u medicini | |
| GB201320729D0 (en) | Therapeutic compounds and their use | |
| HK1254296A1 (zh) | 治療性化合物和其用途 | |
| HK1217092A1 (zh) | 治療性化合物及其用途 | |
| IL244214B (en) | Thienopiperidine derivative and its use | |
| PL3064491T3 (pl) | Pochodna sulfonamidowa i jej zastosowanie medyczne | |
| GB201308440D0 (en) | Therapeutic | |
| GB201311361D0 (en) | Compounds and their therapeutic use | |
| EP2982680A4 (en) | PROTAMINE PEPTIDOMIMETIC AND PHARMACEUTICAL ACCEPTABLE SALTS, AND USE THEREOF | |
| HK1219233A1 (zh) | 美羅培南衍生物及其用途 | |
| GB201318668D0 (en) | Sonosensitive therapeutic | |
| GB201308736D0 (en) | Compounds and their therapeutic use | |
| GB201320786D0 (en) | Medicament | |
| GB201301393D0 (en) | Kiddibidet and pottibidet | |
| GB201316662D0 (en) | Pharmaceutical Combination | |
| EP2996684A4 (en) | THERAPEUTIC PROCEDURES | |
| GB201317804D0 (en) | Therapeutic compounds and their use | |
| GB201316173D0 (en) | Compounds and their therapeutic use | |
| GB201307677D0 (en) | Compounds and their therapeutic use | |
| GB201304166D0 (en) | CelebQuiff and Instant Quiff | |
| AU349561S (en) | Chair | |
| AU349562S (en) | Chair | |
| AU348388S (en) | Chair |