HUP9904091A2 - N-(benzothiazol-2-yl) piperidine-1-ethanamine derivatives, their preparation and application in therapeutics - Google Patents
N-(benzothiazol-2-yl) piperidine-1-ethanamine derivatives, their preparation and application in therapeuticsInfo
- Publication number
- HUP9904091A2 HUP9904091A2 HU9904091A HUP9904091A HUP9904091A2 HU P9904091 A2 HUP9904091 A2 HU P9904091A2 HU 9904091 A HU9904091 A HU 9904091A HU P9904091 A HUP9904091 A HU P9904091A HU P9904091 A2 HUP9904091 A2 HU P9904091A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- benzothiazol
- therapeutics
- piperidine
- preparation
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- SLDOBMOFHWAPFE-UHFFFAOYSA-N n-(2-piperidin-1-ylethyl)-1,3-benzothiazol-2-amine Chemical class N=1C2=CC=CC=C2SC=1NCCN1CCCCC1 SLDOBMOFHWAPFE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A találmány tárgya (I) általánős képletű vegyületek, ahől n értéke 0, 1, 2 vagy 3, R1 jelentése hidrőgén- vagy halőgénatőm, metil- vagy metőxicsőpőrt, R2 jelentése hidrőgénatőm vagy metilcsőpőrt és R3 jelentése hidrőgénatőm vagy egy, vagy két halőgénatőm szabad bázisvagy savaddíciós só főrmában. A vegyületek gyógyszerként használhatókpéldáűl agyi érrendszeri betegségek és pszichózis kezelésében. Atalálmány a vegyületek előállítására szőlgáló eljárásra és avegyületeket tartalmazó gyógyszerkészítményekre is vőnatkőzik. (I) ŕThe subject of the invention is compounds of general formula (I), where n is 0, 1, 2 or 3, R1 is a hydrogen or halogen atom, a methyl or methoxy group, R2 is a hydrogen atom or a methyl group and R3 is a hydrogen atom or one or two halogen atoms, a free base or acid addition salt in boiling water. The compounds can be used as medicine, for example, in the treatment of cerebrovascular diseases and psychosis. The invention also applies to the fermentation process for the production of the compounds and pharmaceutical preparations containing the compounds. (I) ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9611925A FR2753970B1 (en) | 1996-10-01 | 1996-10-01 | N- (BENZOTHIAZOL-2-YL) PIPERIDINE-1-ETHANAMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9904091A2 true HUP9904091A2 (en) | 2000-05-28 |
| HUP9904091A3 HUP9904091A3 (en) | 2000-07-28 |
Family
ID=9496217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904091A HUP9904091A3 (en) | 1996-10-01 | 1997-09-26 | N-(benzothiazol-2-yl) piperidine-1-ethanamine derivatives, their preparation and application in therapeutics |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0929550A1 (en) |
| JP (1) | JP2001501217A (en) |
| KR (1) | KR20000048767A (en) |
| CN (1) | CN1230959A (en) |
| AR (1) | AR009105A1 (en) |
| AU (1) | AU722147B2 (en) |
| BG (1) | BG103271A (en) |
| BR (1) | BR9711842A (en) |
| CA (1) | CA2266510A1 (en) |
| CO (1) | CO4650030A1 (en) |
| CZ (1) | CZ112699A3 (en) |
| EE (1) | EE9900135A (en) |
| FR (1) | FR2753970B1 (en) |
| HU (1) | HUP9904091A3 (en) |
| IL (1) | IL128902A (en) |
| NO (1) | NO991581L (en) |
| NZ (1) | NZ334553A (en) |
| PL (1) | PL332648A1 (en) |
| SK (1) | SK42299A3 (en) |
| TR (1) | TR199900634T2 (en) |
| TW (1) | TW438800B (en) |
| WO (1) | WO1998014444A1 (en) |
| ZA (1) | ZA978772B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725541D0 (en) * | 1997-12-02 | 1998-02-04 | Pharmacia & Upjohn Spa | Amino-benzothiazole derivatives |
| US6107313A (en) * | 1998-10-02 | 2000-08-22 | Combichem, Inc. | Dopamine receptor antagonists |
| HUP0301315A3 (en) * | 2000-06-21 | 2007-10-29 | Hoffmann La Roche | Benzothiazole derivatives, process for their preparation, their use and pharmaceutical compositions containing them |
| US7087761B2 (en) | 2003-01-07 | 2006-08-08 | Hoffmann-La Roche Inc. | Cyclization process for substituted benzothiazole derivatives |
| WO2005040129A2 (en) * | 2003-10-24 | 2005-05-06 | F. Hoffmann-La Roche Ag | Ccr3 receptor antagonists |
| EA011279B1 (en) | 2004-05-24 | 2009-02-27 | Ф. Хоффманн-Ля Рош Аг | 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2yl)-amide |
| DE602005008095D1 (en) | 2004-11-05 | 2008-08-21 | Hoffmann La Roche | PROCESS FOR THE PREPARATION OF ISONICOTINIC ACID DERIVATIVES |
| JP4801724B2 (en) | 2005-03-23 | 2011-10-26 | エフ．ホフマン−ラ ロシュ アーゲー | Acetylenyl-pyrazolo-pyrimidine derivatives as mGluR2 antagonists |
| CN101273040B (en) | 2005-09-27 | 2011-11-09 | 弗·哈夫曼-拉罗切有限公司 | Oxadiazolyl pyrazolo-pyrimidines as MGLUR2 antagonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1260474A (en) * | 1984-12-03 | 1989-09-26 | Raymond A. Stokbroekx | Benzoxazol- and benzothiazolamine derivatives |
| KR930005004B1 (en) * | 1985-04-15 | 1993-06-11 | 쟈안센 파아마슈우티카 엔. 부이. | Process for preparing substituted n-|(4-piperidinyl) alkyl¨ bicycle condensed oxazole and thiazolamines |
-
1996
- 1996-10-01 FR FR9611925A patent/FR2753970B1/en not_active Expired - Fee Related
-
1997
- 1997-09-26 HU HU9904091A patent/HUP9904091A3/en unknown
- 1997-09-26 AU AU44638/97A patent/AU722147B2/en not_active Ceased
- 1997-09-26 PL PL97332648A patent/PL332648A1/en unknown
- 1997-09-26 JP JP10516272A patent/JP2001501217A/en active Pending
- 1997-09-26 IL IL12890297A patent/IL128902A/en not_active IP Right Cessation
- 1997-09-26 CA CA002266510A patent/CA2266510A1/en not_active Abandoned
- 1997-09-26 CZ CZ991126A patent/CZ112699A3/en unknown
- 1997-09-26 EP EP97943001A patent/EP0929550A1/en not_active Ceased
- 1997-09-26 BR BR9711842A patent/BR9711842A/en not_active Application Discontinuation
- 1997-09-26 KR KR1019990702753A patent/KR20000048767A/en not_active Application Discontinuation
- 1997-09-26 EE EEP199900135A patent/EE9900135A/en unknown
- 1997-09-26 CN CN97198112A patent/CN1230959A/en active Pending
- 1997-09-26 CO CO97056315A patent/CO4650030A1/en unknown
- 1997-09-26 TR TR1999/00634T patent/TR199900634T2/en unknown
- 1997-09-26 WO PCT/FR1997/001692 patent/WO1998014444A1/en not_active Application Discontinuation
- 1997-09-26 NZ NZ334553A patent/NZ334553A/en unknown
- 1997-09-26 SK SK422-99A patent/SK42299A3/en unknown
- 1997-09-30 TW TW086114229A patent/TW438800B/en active
- 1997-09-30 ZA ZA9708772A patent/ZA978772B/en unknown
- 1997-09-30 AR ARP970104493A patent/AR009105A1/en not_active Application Discontinuation
-
1999
- 1999-03-22 BG BG103271A patent/BG103271A/en unknown
- 1999-03-30 NO NO991581A patent/NO991581L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1230959A (en) | 1999-10-06 |
| BR9711842A (en) | 1999-08-24 |
| AR009105A1 (en) | 2000-03-08 |
| SK42299A3 (en) | 1999-12-10 |
| CZ112699A3 (en) | 1999-06-16 |
| WO1998014444A1 (en) | 1998-04-09 |
| FR2753970B1 (en) | 1998-10-30 |
| NZ334553A (en) | 2000-11-24 |
| CA2266510A1 (en) | 1998-04-09 |
| IL128902A (en) | 2001-07-24 |
| KR20000048767A (en) | 2000-07-25 |
| BG103271A (en) | 2000-05-31 |
| NO991581L (en) | 1999-06-01 |
| TW438800B (en) | 2001-06-07 |
| HUP9904091A3 (en) | 2000-07-28 |
| JP2001501217A (en) | 2001-01-30 |
| AU722147B2 (en) | 2000-07-20 |
| PL332648A1 (en) | 1999-09-27 |
| CO4650030A1 (en) | 1998-09-03 |
| AU4463897A (en) | 1998-04-24 |
| IL128902A0 (en) | 2000-02-17 |
| ZA978772B (en) | 1998-03-27 |
| FR2753970A1 (en) | 1998-04-03 |
| TR199900634T2 (en) | 1999-06-21 |
| EE9900135A (en) | 1999-12-15 |
| NO991581D0 (en) | 1999-03-30 |
| EP0929550A1 (en) | 1999-07-21 |
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