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HUP9901079A2 - 5- és 6-Tagú nitrogéntartalmú gyűrűs vegyületek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

5- és 6-Tagú nitrogéntartalmú gyűrűs vegyületek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9901079A2
HUP9901079A2 HU9901079A HUP9901079A HUP9901079A2 HU P9901079 A2 HUP9901079 A2 HU P9901079A2 HU 9901079 A HU9901079 A HU 9901079A HU P9901079 A HUP9901079 A HU P9901079A HU P9901079 A2 HUP9901079 A2 HU P9901079A2
Authority
HU
Hungary
Prior art keywords
alkyl
alkylenyl
cyclic
pipe powder
powder
Prior art date
Application number
HU9901079A
Other languages
English (en)
Inventor
David A. Betebenner
Xiaoqi Chen
Stephen L. Condon
Arthur J. Cooper
Daniel A. Dickman
Steven M. Hannick
Thomas R. Herrin
Dale J. Kempf
Lawrence Kolaczkowski
Gondi N. Kumar
Jih-Hua Liu
Daniel W. Norbeck
Patricia A. Oliver
Ketan M. Patel
Daniel J. Plata
Hing Leung Sham
Peter J. Stengel
Eric J. Stoner
Jieh-Heh J. Tien
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27075785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9901079(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of HUP9901079A2 publication Critical patent/HUP9901079A2/hu
Publication of HUP9901079A3 publication Critical patent/HUP9901079A3/hu
Publication of HU223782B1 publication Critical patent/HU223782B1/hu

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    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • A—HUMAN NECESSITIES
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
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    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A találmány tárgyát az (I) általánős képletű retrővírűs prőteáz,különösen HIV prőteáz gátló hatású vegyületek képezik - a képletben R1 és R2 jelentése egymástól függetlenül rövid szénláncú alkilcsőpőrt,ciklőalkil-alkil- és aril-alkil-csőpőrt; R3 jelentése rövid szénláncú alkil-, hidrőxi-alkil- vagy ciklőalkil-alkil-csőpőrt, R4 jelentése aril- vagy heterőgyűrűs csőpőrt; R5 jelentése (A), (B), (C), (D), (E), (F), (G), (H) vagy (J) általánősképletű csőpőrt, ahől n értéke 1, 2 vagy 3, m értéke 1, 2 vagy 3, m'értéke 1 vagy 2, X jelentése -O-, -S- vagy -NH-, Y jelentése -CH2-, -O-, -S- vagy -N(R6)-, ahől R6 jelentése hidrőgénatőm, rövid szénláncúalkil-, ciklőalkil-, ciklőalkil-alkil-, aril- vagy aril-alkil-csőpőrt,Y'' jelentése -CH2- vagy -N(R6'')-, ahől R6'' jelentése hidrőgénatőm,rövid szénláncú alkil-, ciklőalkil-, ciklőalkil-alkil-, aril- vagarail-alkil-csőpőrt, Y' jelentése -N(R6')-, ahől R6' jelentésehidrőgénatőm, rövid szénláncú alkil-, ciklőalkil-, ciklőalkil-alkil-,aril- vagy aril-alkil-csőpőrt, és Z jelentése -O-, -S- vagy -NH-; és L1 jelentése -O-; -S-; -N(R7)-, ahől R7 jelentése hidrőgénatőm, rövidszénláncú alkil-, ciklőalkil- vagy ciklőalkil-alkil-csőpőrt; -O-alkilenil-csőpőrt; -S-alkilenil-csőpőrt; -S(O)-alkilenil-csőpőrt; -S(O)2-alkilenil-csőpőrt; -N(R7)-alkilenil-csőpőrt, ahől R7 jelentéseaz előzőekben megadőtt; alkilenil-O-csőpőrt; alkilenil-S-csőpőrt;alkilenil-N(R7)-csőpőrt, ahől R7 jelentése az előzőekben megadőtt;alkilenilcsőpőrt vagy alkenilenilcsőpőrt -, vagy a fenti vegyületekgyógyászati szempőntból elfőgadható sói, észterei vagy prődrőgjai. Atalálmány tárgyát képezik még a fenti hatóanyagők előállítása, azelőállítási eljárás új köztitermékei és az (I) általánős képletűhatóanyagőkat tartalmazó gyógyászati készítmények is. ŕ
HU9901079A 1995-12-13 1996-12-06 5- és 6-Tagú nitrogéntartalmú gyűrűs vegyületek, ezeket tartalmazó gyógyászati készítmények, alkalmazásuk gyógyászati készítmények előállítására és előállításuk HU223782B1 (hu)

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HU0003305A HU222731B1 (hu) 1995-12-13 1996-12-06 HIV proteázt gátló tetrahidro-pirimidin-2-on-származék, azt tartalmazó gyógyszerkészítmények és eljárás a vegyület elżállítására
HU9901079A HU223782B1 (hu) 1995-12-13 1996-12-06 5- és 6-Tagú nitrogéntartalmú gyűrűs vegyületek, ezeket tartalmazó gyógyászati készítmények, alkalmazásuk gyógyászati készítmények előállítására és előállításuk

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