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HUP0301834A3 - Use of heterocyclic dihydropyrimidine derivatives for the preparation of pharmaceutical compositions with potassim channel activity, novel derivatives and pharmaceutical compositions containing them - Google Patents

Use of heterocyclic dihydropyrimidine derivatives for the preparation of pharmaceutical compositions with potassim channel activity, novel derivatives and pharmaceutical compositions containing them

Info

Publication number
HUP0301834A3
HUP0301834A3 HU0301834A HUP0301834A HUP0301834A3 HU P0301834 A3 HUP0301834 A3 HU P0301834A3 HU 0301834 A HU0301834 A HU 0301834A HU P0301834 A HUP0301834 A HU P0301834A HU P0301834 A3 HUP0301834 A3 HU P0301834A3
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
derivatives
potassim
preparation
channel activity
Prior art date
Application number
HU0301834A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HUP0301834A2 publication Critical patent/HUP0301834A2/hu
Publication of HUP0301834A3 publication Critical patent/HUP0301834A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
HU0301834A 1999-12-06 2000-12-04 Use of heterocyclic dihydropyrimidine derivatives for the preparation of pharmaceutical compositions with potassim channel activity, novel derivatives and pharmaceutical compositions containing them HUP0301834A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16909199P 1999-12-06 1999-12-06
US23603700P 2000-09-28 2000-09-28
PCT/US2000/032785 WO2001040231A1 (en) 1999-12-06 2000-12-04 Heterocyclic dihydropyrimidines as potassium channel inhibitors

Publications (2)

Publication Number Publication Date
HUP0301834A2 HUP0301834A2 (hu) 2003-09-29
HUP0301834A3 true HUP0301834A3 (en) 2004-11-29

Family

ID=26864749

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301834A HUP0301834A3 (en) 1999-12-06 2000-12-04 Use of heterocyclic dihydropyrimidine derivatives for the preparation of pharmaceutical compositions with potassim channel activity, novel derivatives and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (3) US6706720B2 (xx)
EP (1) EP1237891B1 (xx)
JP (1) JP2004507442A (xx)
KR (1) KR20020060255A (xx)
CN (1) CN1407985A (xx)
AR (1) AR029457A1 (xx)
AT (1) ATE526329T1 (xx)
AU (1) AU781862B2 (xx)
BR (1) BR0016166A (xx)
CA (1) CA2393809C (xx)
CO (1) CO5570109A1 (xx)
CZ (1) CZ20021949A3 (xx)
HK (1) HK1048808A1 (xx)
HU (1) HUP0301834A3 (xx)
IL (2) IL149473A0 (xx)
MX (1) MXPA02005533A (xx)
MY (1) MY125533A (xx)
NO (1) NO323588B1 (xx)
NZ (1) NZ518663A (xx)
PE (1) PE20011029A1 (xx)
PL (1) PL364926A1 (xx)
RU (1) RU2296766C2 (xx)
TW (1) TWI291465B (xx)
UY (1) UY26472A1 (xx)
WO (1) WO2001040231A1 (xx)

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GB9901691D0 (en) 1999-01-26 1999-03-17 Cerebrus Ltd Chemical compounds
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
AU7306201A (en) * 2000-06-30 2002-01-14 American Home Prod Substituted-triazolopyrimidines as anticancer agents
SK287972B6 (sk) * 2000-12-25 2012-08-06 Daiichi Sankyo Company Limited Pharmaceutical composition comprising 2-acetoxypyridine derivative and aspirin, kit comprising these compounds and use thereof
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
AU2002341123A1 (en) * 2001-05-05 2002-11-18 Smithkline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
EP1956020A3 (en) 2001-05-05 2008-08-20 Smithkline Beecham Plc 1-[2-(heterocyclyl-aminomethyl)-piperidin-1-YL]-1-(2-methyl-5-phenyl-heterocyclyl)-methanone derivatives and related compounds as orexin-1 antagonists for the treatment of obesity
US7139344B2 (en) * 2001-05-16 2006-11-21 Lexmark International, Inc. Method and apparatus for effecting synchronous pulse generation for use in variable speed serial communications
CN1549816A (zh) * 2001-06-28 2004-11-24 ʷ 作为阿立新受体拮抗药的n-芳酰基环胺衍生物
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
KR100909141B1 (ko) 2001-09-21 2009-07-23 브리스톨-마이어스스퀴브컴파니 인자 Ｘａ 억제제로서의 락탐-함유 화합물 및 그의 유도체
ATE541847T1 (de) * 2001-11-01 2012-02-15 Icagen Inc Pyrazolopyrimidine als natriumkanalblocker
US7435824B2 (en) 2002-04-19 2008-10-14 Bristol-Myers Squibb Company Prodrugs of potassium channel inhibitors
EP1511751B1 (en) * 2002-06-04 2008-03-19 Neogenesis Pharmaceuticals, Inc. Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents
EP1594854B1 (en) 2003-02-06 2010-09-01 Bristol-Myers Squibb Company Thiazolyl-based compounds useful as kinase inhibitors
US6846836B2 (en) 2003-04-18 2005-01-25 Bristol-Myers Squibb Company N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase
PL1618092T3 (pl) 2003-05-01 2011-02-28 Bristol Myers Squibb Co Związki amidopirazolowe z podstawnikami arylowymi jako inhibitory kinazy
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
CA2543707A1 (en) * 2003-10-31 2005-05-19 Takeda Pharmaceutical Company Limited Nitrogen-containing fused heterocyclic compounds
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
JP4880591B2 (ja) 2004-06-04 2012-02-22 テバ ファーマシューティカル インダストリーズ リミティド イルベサルタンを含む医薬組成物
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7253167B2 (en) * 2004-06-30 2007-08-07 Bristol-Myers Squibb Company Tricyclic-heteroaryl compounds useful as kinase inhibitors
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AU781862B2 (en) 2005-06-16
US20070099899A1 (en) 2007-05-03
HUP0301834A2 (hu) 2003-09-29
AU1812701A (en) 2001-06-12
MY125533A (en) 2006-08-30
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NO20022649D0 (no) 2002-06-05
US20040063687A1 (en) 2004-04-01
EP1237891A1 (en) 2002-09-11
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CA2393809C (en) 2009-11-17
TWI291465B (en) 2007-12-21
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IL149473A (en) 2009-05-04
ATE526329T1 (de) 2011-10-15
US6706720B2 (en) 2004-03-16
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