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HUP0102422A2 - Rákellenes hatású izotiazolszármazékok, ilyen vegyületeket tartalmazó gyógyszerkészítmények és az előállítási eljárások - Google Patents

Rákellenes hatású izotiazolszármazékok, ilyen vegyületeket tartalmazó gyógyszerkészítmények és az előállítási eljárások

Info

Publication number
HUP0102422A2
HUP0102422A2 HU0102422A HUP0102422A HUP0102422A2 HU P0102422 A2 HUP0102422 A2 HU P0102422A2 HU 0102422 A HU0102422 A HU 0102422A HU P0102422 A HUP0102422 A HU P0102422A HU P0102422 A2 HUP0102422 A2 HU P0102422A2
Authority
HU
Hungary
Prior art keywords
group
groups
aryl
compounds
carbon
Prior art date
Application number
HU0102422A
Other languages
English (en)
Inventor
Thomas George Gant
Eric Robert Larson
Mark Carl Noe
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0102422A2 publication Critical patent/HUP0102422A2/hu
Publication of HUP0102422A3 publication Critical patent/HUP0102422A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/58—Derivatives of thiocarboxylic acids, the doubly-bound oxygen atoms being replaced by nitrogen atoms, e.g. imino-thio ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A találmány emlősökben hiperproliferatív betegségek, például rákkezelésére alkalmas új, (I) általános képletű izotiazol-származékokra,gyógyászatilag elfogadható sóira, prodrugjaira és szolvátjairavonatkozik; X1, R1, R2 és R3 jelentése az alábbiakban megadott. Atalálmány kiterjed az ilyen vegyületek alkalmazására emlősökbenhiperproliferatív betegségek kezelésére alkalmas gyógyászatikészítmények előállítására, valamint az ilyen vegyületeket tartalmazógyógyászati készítményekre. X1 jelentése oxigén- vagy kénatom, R1jelentése hidrogénatom, 1-10 szénatomos alkilcsoport, 2-10 szénatomosalkenilcsoport, -C(O)-(1-10 szénatomos alkil)-csoport, -(CH2)t-(6-10szénatomos aril)-csoport, -(CH2)t-(9-10 tagú heterociklusos)-csoport,-C(O)(CH2)t-(6-10 szénatomos aril)-csoport vagy -C(O)(CH2)t-(5-10szénatomos heterociklusos)-csoport, ahol t értéke 0-5: az említettalkilcsoport adott esetben oxigénatom, kénatom vagy -N(R6)-csoportokközül választott egy vagy két heterorészletet tartalmaz, R2 jelentéseaz R1 definíciójában megadottakkal azonos, valamint -SO2(CH2)t-(5-10szénatomos aril)-csoport, -SO2(CH2)t-(5-10 tagú heterociklusos)-csoport és -OR5, t értéke 0-5, az említett R2 csoportok -(CH2)t-egységei adott esetben szén-szén kettős vagy hármaskötésttartalmaznak, ahol t értéke 2-5; és az említett R2 csoportok ahidrogénatom kivételével adott esetben 1-3, R4 csoporttalszubsztituáltak; R3 jelentése hidrogénatom, 1-10 szénatomosalkilcsoport, 2-10 szénatomos alkenilcsoport, 2-10 szénatomosalkinilcsoport, -(CH2)t- (6-10 szénatomos aril)-csoport vagy -(CH2)t-(5-10 tagú heterociklusos)-csoport, ahol t értéke 0-5; az említettalkilcsoport adott esetben oxigénatom, kénatom vagy -N(R6)-csoportokközül választott egy vagy két heterorészletet tartalmaz. Ó
HU0102422A 1998-06-04 1999-05-03 Isothiazole derivatives useful as anticancer agents, pharmaceutical compositions containing such compounds and processes for their preparation HUP0102422A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8796398P 1998-06-04 1998-06-04

Publications (2)

Publication Number Publication Date
HUP0102422A2 true HUP0102422A2 (hu) 2002-05-29
HUP0102422A3 HUP0102422A3 (en) 2002-06-28

Family

ID=22208298

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102422A HUP0102422A3 (en) 1998-06-04 1999-05-03 Isothiazole derivatives useful as anticancer agents, pharmaceutical compositions containing such compounds and processes for their preparation

Country Status (46)

Country Link
US (4) US6235764B1 (hu)
EP (1) EP1084114B1 (hu)
JP (2) JP3735254B2 (hu)
KR (1) KR100392434B1 (hu)
CN (2) CN1616386A (hu)
AP (1) AP1309A (hu)
AR (1) AR016725A1 (hu)
AT (1) ATE275553T1 (hu)
AU (1) AU3342199A (hu)
BG (1) BG65104B1 (hu)
BR (1) BR9910900B1 (hu)
CA (2) CA2333703C (hu)
CO (1) CO5011121A1 (hu)
CZ (1) CZ298559B6 (hu)
DE (1) DE69920009T2 (hu)
EA (1) EA004935B1 (hu)
ES (1) ES2226368T3 (hu)
GE (1) GEP20084337B (hu)
GT (1) GT199900070A (hu)
HK (1) HK1036982A1 (hu)
HN (1) HN1999000080A (hu)
HR (1) HRP20000835B1 (hu)
HU (1) HUP0102422A3 (hu)
ID (1) ID27006A (hu)
IL (1) IL138776A0 (hu)
IS (1) IS2269B (hu)
MA (1) MA26638A1 (hu)
MY (1) MY130668A (hu)
NO (1) NO318798B1 (hu)
NZ (1) NZ507009A (hu)
OA (1) OA11504A (hu)
PA (1) PA8472301A1 (hu)
PE (1) PE20000568A1 (hu)
PL (1) PL198151B1 (hu)
PT (1) PT1084114E (hu)
SA (1) SA99200217B1 (hu)
SI (1) SI1084114T1 (hu)
SK (1) SK286405B6 (hu)
TN (1) TNSN99106A1 (hu)
TR (1) TR200003478T2 (hu)
TW (1) TW561154B (hu)
UA (1) UA60365C2 (hu)
UY (1) UY25619A1 (hu)
WO (1) WO1999062890A1 (hu)
YU (1) YU70100A (hu)
ZA (1) ZA993752B (hu)

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JP2005002122A (ja) 2005-01-06
SK286405B6 (sk) 2008-09-05
BG104998A (en) 2001-07-31
NZ507009A (en) 2003-11-28
AU3342199A (en) 1999-12-20
US7405218B2 (en) 2008-07-29
KR100392434B1 (ko) 2003-07-22
SK17782000A3 (sk) 2001-08-06
GEP20084337B (hu) 2008-03-25
CA2333703A1 (en) 1999-12-09
JP2002517384A (ja) 2002-06-18
CN1172918C (zh) 2004-10-27
UY25619A1 (es) 2000-02-23
PT1084114E (pt) 2004-12-31
CN1616386A (zh) 2005-05-18
EA200001146A1 (ru) 2001-04-23
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US20010020034A1 (en) 2001-09-06
SI1084114T1 (en) 2005-02-28
AP9901560A0 (en) 1999-06-30
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CN1303380A (zh) 2001-07-11
OA11504A (en) 2004-05-17
NO318798B1 (no) 2005-05-09
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CZ20004451A3 (en) 2001-05-16
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AP1309A (en) 2004-09-14
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US7790902B2 (en) 2010-09-07
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HN1999000080A (es) 1999-09-29
CA2475113A1 (en) 1999-12-09
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