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HUE030413T2 - Szubsztituált pirazolo[1,5-a]pirimidin vegyületek mint TRK kináz inhibitorok elõállításának köztitermékei - Google Patents

Szubsztituált pirazolo[1,5-a]pirimidin vegyületek mint TRK kináz inhibitorok elõállításának köztitermékei Download PDF

Info

Publication number
HUE030413T2
HUE030413T2 HUE13197815A HUE13197815A HUE030413T2 HU E030413 T2 HUE030413 T2 HU E030413T2 HU E13197815 A HUE13197815 A HU E13197815A HU E13197815 A HUE13197815 A HU E13197815A HU E030413 T2 HUE030413 T2 HU E030413T2
Authority
HU
Hungary
Prior art keywords
pyrrolidin
pyrazolo
pyrimidin
mmol
difluorophenyl
Prior art date
Application number
HUE13197815A
Other languages
English (en)
Inventor
Julia Haas
Steven W Andrews
Yutong Jiang
Gan Zhang
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41328903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE030413(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of HUE030413T2 publication Critical patent/HUE030413T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (3)

  1. Szabadalmi igénypontok
    1, Vegyülsi, amely a kővetkező csoportból vart kjváiasKtvá: - alábbi képietö vegyidet:
    vagy ennek gyógyszerészeti jog elfogadható sója, és - alábbi képietö vegyüleí:
    vagy mmk gyógyszéréSxetiíeg elfogadható sója,
  2. 2, Egy m, 1 - igénypont szerinti vegyüleí, amely az - alábbi képietö vegyüléí:
    vagy ennek gyógy szerésKetlisg elfogadható sója;
  3. 3, Egy az i , igénypont szerinti vegyidet, amely ax - alábbi képiét« vegyit let:
    vagy ennek gyógyszerészetiíeg -elfogadható sója. 119476-14Ő97A FO/TÈ
HUE13197815A 2008-10-22 2009-10-21 Szubsztituált pirazolo[1,5-a]pirimidin vegyületek mint TRK kináz inhibitorok elõállításának köztitermékei HUE030413T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10761608P 2008-10-22 2008-10-22

Publications (1)

Publication Number Publication Date
HUE030413T2 true HUE030413T2 (hu) 2017-05-29

Family

ID=41328903

Family Applications (4)

Application Number Title Priority Date Filing Date
HUE13197815A HUE030413T2 (hu) 2008-10-22 2009-10-21 Szubsztituált pirazolo[1,5-a]pirimidin vegyületek mint TRK kináz inhibitorok elõállításának köztitermékei
HUE16166461A HUE037716T2 (hu) 2008-10-22 2009-10-21 Szubsztituált pirazolo[l,5-a]pirimidin vegyületek mint TRK kináz inhibitorok
HUE18151233A HUE057625T2 (hu) 2008-10-22 2009-10-21 TRK kináz inhibitor szubsztituált pirazolo[1,5-a]pirimidin vegyületek
HUS2000006C HUS000512I2 (hu) 2008-10-22 2020-03-11 Larotrektinib és/vagy gyógyszerészetileg elfogadható sói, elõnyösen larotrektinib-szulfát, beleértve a larotrektinib-hidrogénszulfátot

Family Applications After (3)

Application Number Title Priority Date Filing Date
HUE16166461A HUE037716T2 (hu) 2008-10-22 2009-10-21 Szubsztituált pirazolo[l,5-a]pirimidin vegyületek mint TRK kináz inhibitorok
HUE18151233A HUE057625T2 (hu) 2008-10-22 2009-10-21 TRK kináz inhibitor szubsztituált pirazolo[1,5-a]pirimidin vegyületek
HUS2000006C HUS000512I2 (hu) 2008-10-22 2020-03-11 Larotrektinib és/vagy gyógyszerészetileg elfogadható sói, elõnyösen larotrektinib-szulfát, beleértve a larotrektinib-hidrogénszulfátot

Country Status (39)

Country Link
US (11) US8513263B2 (hu)
EP (4) EP3106463B3 (hu)
JP (5) JP5600111B2 (hu)
KR (5) KR101853026B1 (hu)
CN (2) CN103509017B (hu)
AR (2) AR074052A1 (hu)
AU (1) AU2009308465B2 (hu)
BR (1) BRPI0919873B8 (hu)
CA (1) CA2741313C (hu)
CL (1) CL2011000880A1 (hu)
CO (1) CO6440551A2 (hu)
CR (1) CR20110261A (hu)
CY (4) CY1118199T1 (hu)
DK (4) DK2350071T3 (hu)
ES (4) ES2669581T7 (hu)
HK (2) HK1160640A1 (hu)
HR (3) HRP20211722T1 (hu)
HU (4) HUE030413T2 (hu)
IL (3) IL212341A0 (hu)
LT (4) LT2725028T (hu)
LU (1) LUC00150I2 (hu)
ME (1) ME03010B (hu)
MX (1) MX2011004204A (hu)
MY (1) MY169791A (hu)
NL (1) NL301033I2 (hu)
NO (2) NO3106463T3 (hu)
NZ (1) NZ592809A (hu)
PL (4) PL2725028T3 (hu)
PT (4) PT3372605T (hu)
RS (3) RS57221B2 (hu)
RU (1) RU2018131134A (hu)
SG (3) SG196855A1 (hu)
SI (4) SI3106463T1 (hu)
SM (2) SMT201800244T1 (hu)
TR (1) TR201807039T4 (hu)
TW (4) TWI639605B (hu)
UA (1) UA106054C2 (hu)
UY (1) UY32192A (hu)
WO (1) WO2010048314A1 (hu)

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