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HU201318B - Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same - Google Patents

Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same Download PDF

Info

Publication number
HU201318B
HU201318B HU876170A HU617087A HU201318B HU 201318 B HU201318 B HU 201318B HU 876170 A HU876170 A HU 876170A HU 617087 A HU617087 A HU 617087A HU 201318 B HU201318 B HU 201318B
Authority
HU
Hungary
Prior art keywords
formula
compound
alkyl
acid addition
addition salt
Prior art date
Application number
HU876170A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT50144A (en
Inventor
Laszlo Rozsa
Lujza Petoecz
Kiszelly Enikoe Szirtne
Marton Fekete
Hegedues Maria Szecseyne
Gabor Gigler
Istvan Gacsalyi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to HU876170A priority Critical patent/HU201318B/hu
Priority to JP63329542A priority patent/JPH01213273A/ja
Priority to CH4833/88A priority patent/CH677669A5/de
Priority to SE8804696A priority patent/SE8804696L/xx
Priority to FR8817385A priority patent/FR2625503A1/fr
Priority to SU884613167A priority patent/SU1641190A3/ru
Priority to US07/292,450 priority patent/US4965259A/en
Priority to BE8801449A priority patent/BE1002696A3/fr
Priority to FI886065A priority patent/FI886065A/fi
Priority to YU02400/88A priority patent/YU240088A/xx
Priority to CS889102A priority patent/CS272247B2/cs
Priority to DE3844394A priority patent/DE3844394A1/de
Priority to CN88108995A priority patent/CN1034926A/zh
Priority to DK733688A priority patent/DK733688A/da
Priority to AU27637/88A priority patent/AU610678B2/en
Priority to GB8830416A priority patent/GB2213480B/en
Priority to KR1019880018006A priority patent/KR890009896A/ko
Priority to PL1988276891A priority patent/PL154357B1/pl
Priority to NL8803218A priority patent/NL8803218A/nl
Priority to ES8900367A priority patent/ES2010855A6/es
Priority to IT8823183A priority patent/IT1227920B/it
Priority to GR880100870A priority patent/GR1000098B/el
Publication of HUT50144A publication Critical patent/HUT50144A/hu
Publication of HU201318B publication Critical patent/HU201318B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/01—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having one nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU876170A 1987-12-31 1987-12-31 Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same HU201318B (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
HU876170A HU201318B (en) 1987-12-31 1987-12-31 Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same
JP63329542A JPH01213273A (ja) 1987-12-31 1988-12-28 ジオキサゾシン誘導体、その製造方法、およびこれを含有する組成物を主成分とする中枢神経系作用薬
CH4833/88A CH677669A5 (da) 1987-12-31 1988-12-28
SE8804696A SE8804696L (sv) 1987-12-31 1988-12-29 Dioxazocin- derivat, deras framstaellning och beredningar innehaallande desamma
FR8817385A FR2625503A1 (fr) 1987-12-31 1988-12-29 Derives de dioxazocine, leur procede de preparation et compositions pharmaceutiques les contenant
SU884613167A SU1641190A3 (ru) 1987-12-31 1988-12-30 Способ получени производных 12Н-дибензо( @ , @ )(1,3,6)диоксазоцина в виде их кислотно-аддитивных солей
US07/292,450 US4965259A (en) 1987-12-31 1988-12-30 Dioxazocine derivatives compositions and methods containing them having antidepressive, spasmolytic, anticonvulsive, and antiarrhythmic properties
BE8801449A BE1002696A3 (fr) 1987-12-31 1988-12-30 Derives de dioxazocine, leur procede de preparation et compositions pharmaceutiques les contenant.
FI886065A FI886065A (fi) 1987-12-31 1988-12-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara dioxazocinderivat.
YU02400/88A YU240088A (en) 1987-12-31 1988-12-30 Process for obtaining dioxazocine derivative
CS889102A CS272247B2 (en) 1987-12-31 1988-12-30 Method of dioxazocine's derivatives production
DE3844394A DE3844394A1 (de) 1987-12-31 1988-12-30 2-(chlor)-12-((omega)(alkylamino)-alkyl)-12h- dibenzo(d,g)(1,3,6)dioxazocinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
CN88108995A CN1034926A (zh) 1987-12-31 1988-12-30 二吖辛因衍生物的制法
DK733688A DK733688A (da) 1987-12-31 1988-12-30 Dioxazocinderivater
AU27637/88A AU610678B2 (en) 1987-12-31 1988-12-30 Dioxazocine derivatives, their preparation and compositions containing them
GB8830416A GB2213480B (en) 1987-12-31 1988-12-30 Dioxazocine derivatives, their preparation and compositions containing them
KR1019880018006A KR890009896A (ko) 1987-12-31 1988-12-30 디옥사조신 유도체, 그의 제법 및 그를 함유하는 조성물
PL1988276891A PL154357B1 (en) 1987-12-31 1988-12-30 Method of obtaining novel derivatives of dioxazocine
NL8803218A NL8803218A (nl) 1987-12-31 1988-12-30 Dioxazocinederivaten, hun bereiding en samenstellingen die ze bevatten.
ES8900367A ES2010855A6 (es) 1987-12-31 1988-12-30 Procedimiento de preparacion de derivados de dioxazocina.
IT8823183A IT1227920B (it) 1987-12-31 1988-12-30 Derivati diossazocinici, loro preparazione e composizioni che li contengono
GR880100870A GR1000098B (el) 1987-12-31 1988-12-30 Παραγωγα διοξαζοκινης, παρασκευη των και συνθεσεις που τα περιεχουν.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU876170A HU201318B (en) 1987-12-31 1987-12-31 Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
HUT50144A HUT50144A (en) 1989-12-28
HU201318B true HU201318B (en) 1990-10-28

Family

ID=10971300

Family Applications (1)

Application Number Title Priority Date Filing Date
HU876170A HU201318B (en) 1987-12-31 1987-12-31 Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same

Country Status (22)

Country Link
US (1) US4965259A (da)
JP (1) JPH01213273A (da)
KR (1) KR890009896A (da)
CN (1) CN1034926A (da)
AU (1) AU610678B2 (da)
BE (1) BE1002696A3 (da)
CH (1) CH677669A5 (da)
CS (1) CS272247B2 (da)
DE (1) DE3844394A1 (da)
DK (1) DK733688A (da)
ES (1) ES2010855A6 (da)
FI (1) FI886065A (da)
FR (1) FR2625503A1 (da)
GB (1) GB2213480B (da)
GR (1) GR1000098B (da)
HU (1) HU201318B (da)
IT (1) IT1227920B (da)
NL (1) NL8803218A (da)
PL (1) PL154357B1 (da)
SE (1) SE8804696L (da)
SU (1) SU1641190A3 (da)
YU (1) YU240088A (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198194B (en) * 1986-12-30 1989-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of new derivatives of dioxazocin and medical compositions containing them
DK0423870T3 (da) * 1989-10-20 1993-10-11 Akzo Nobel Nv Dibenzodioxazecin- dibenzodioxaazacycloundecinderivater
WO1997011071A1 (en) * 1995-09-19 1997-03-27 Novo Nordisk A/S Novel heterocyclic compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL108827C (da) * 1956-04-09
US3258459A (en) * 1962-08-30 1966-06-28 Squibb & Sons Inc Method for the preparation of n-monosubstituted-secondary aminoalkyl derivatives of polycyclic compounds
US3803143A (en) * 1969-09-08 1974-04-09 Eisai Co Ltd 6-amino alkylene 6,7-dihydro-5h-dibenzo (b,g),(1,5)thiazocines
GB1464431A (en) * 1974-03-25 1977-02-16 Roche Products Ltd Indolobenzazepine derivatives and a process for the manufacture thereof
HU174126B (hu) * 1977-08-02 1979-11-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija novykh proizvodnykh dibenzo-kvadratnaja skobka-d,g-kvadratnaja skobka zakryta-kvadratnaja skobka-1,3,6-kvadratnaja skobka zakryta-dioksazocina
HU195491B (en) * 1985-12-20 1988-05-30 Egyt Gyogyszervegyeszeti Gyar Process for production of optically active 2-chlor-12-/3-/dimethil-amin/-2-methil-prophil/-12h-dibenzol /d,g/ /1,3,6/-diaxazocine and medical compositions containing such compounds
HU198194B (en) * 1986-12-30 1989-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of new derivatives of dioxazocin and medical compositions containing them

Also Published As

Publication number Publication date
FR2625503A1 (fr) 1989-07-07
PL276891A1 (en) 1989-12-27
PL154357B1 (en) 1991-08-30
CH677669A5 (da) 1991-06-14
IT1227920B (it) 1991-05-14
AU610678B2 (en) 1991-05-23
GB8830416D0 (en) 1989-03-01
ES2010855A6 (es) 1989-12-01
GR1000098B (el) 1991-03-15
SE8804696D0 (sv) 1988-12-29
HUT50144A (en) 1989-12-28
IT8823183A0 (it) 1988-12-30
GB2213480B (en) 1991-06-26
CS272247B2 (en) 1991-01-15
DE3844394A1 (de) 1989-07-13
FI886065A (fi) 1989-07-01
SU1641190A3 (ru) 1991-04-07
GB2213480A (en) 1989-08-16
AU2763788A (en) 1989-07-06
US4965259A (en) 1990-10-23
NL8803218A (nl) 1989-07-17
YU240088A (en) 1990-02-28
CN1034926A (zh) 1989-08-23
BE1002696A3 (fr) 1991-05-07
DK733688A (da) 1989-07-01
CS910288A2 (en) 1990-03-14
JPH01213273A (ja) 1989-08-28
KR890009896A (ko) 1989-08-04
DK733688D0 (da) 1988-12-30
SE8804696L (sv) 1989-07-01

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee