HU192885B - Disinfecting compositions and process for the preparation thereof - Google Patents

Abstract

The invention relates to a disinfecting preparation, in particular for disinfecting the surface of the skin, and a process for preparing it. The disinfecting preparation according to the invention is characterised in that it comprises 0.5 to 35% by weight of one or more disinfectants, 1-20% by weight of one of more non-ionic emulsifiers, preferably polyethylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyethylene glycol alkyl ethers or mixtures of these, 40 to 80% by weight of one of more diluents, preferably polyethylene glycol(s), propylene glycol, glycerol, water or mixtures of these, and 0 to 10% by weight of one or more additives, preferably one or more colourants and/or perfumes.

Description

The present invention relates to a disinfectant composition and a process for its preparation.

The composition according to the invention is used primarily for disinfecting the boron surface, for example as a hygienic hand disinfectant, a surgical first detergent, etc. can be used.

Pathogenic bacteria on the skin surface, such as Staphylococcus aureus,

Escherichia coli, SalmoneUa typhi, Pseudomo ¹ naa aeruginosa, Proteue vulgaris and the like. • Remove 1 bag as efficiently as possible. Particularly in health care and in certain industrial, such as food and hospitality establishments, the removal and destruction of pathogens on the body surface, especially effective hand cleaning and hand disinfection, is of great importance, since the pathogens can cause mass diseases and epidemics in these places.

In practice, body surface cleaning is accomplished by washing with soap and warm water, but many known disinfectants can be used for this purpose (H.Ippen, Index Pharmacorum, Georg Thieme Verlag, Stuttgart, 1970, 510-515). side].

For example, it has been stated that hand cleaning should be carried out for at least 30 seconds in order to have a somewhat acceptable cleansing and disinfecting effect; however, most people only wash their hands for 10 to 15 seconds (Seifen-ule-Fette-Wachee, 109 (3), 71-74 (1983)). This short-term treatment does not, to a large extent, ensure the elimination of most of the pathogens present on the skin. In addition, it has been found that known disinfectants do not produce acceptable levels of disinfection within 30 seconds of treatment.

It is an object of the present invention to provide a composition which has a significantly increased disinfectant effect compared to the known compositions.

It has now been found that the above object is achieved by a composition comprising from 0.5 to 35 mg of one or more compounds of formula I wherein Ar is benzylCoporl, C 1-4 alkyl or phenoxy (C 1-3). ) alkyl,

R 1 and R 1 are methyl, R 1 is 6 to 6 alkylene-B alkyl, X is a halogen ion, preferably a chloride or bromide ion, containing from 1 to 20 radicals of one or more polyethylene glycol alkyl or alkenyl ethers, wherein polyethylene glycol has a degree of polymerization of 2 to 23, and the alkyl or alkenyl group has 10 to 20 carbon atoms in the range of 40 to 80 wt. got / contains materials.

The present invention is based on the discovery that the disinfectant effect of known disinfectant ethers of formula (I) is increased dramatically when one or more compounds of formula (I) and one or more polyethylene glycol alkyl or alkenyl ethers are used together, although the latter, as nonionic eraul gels, have virtually no disinfectant effect. Surprisingly, the combination of the compounds of formula (I) and the polyethylene glycol ethers provides a disinfectant of greater than 80X in accordance with MSz-03 67 / 1-79bz. Healthy Food Industry Sector Standard measured by thousands.

Suitable compounds of the formula I for use in the composition of the invention are as follows:

trimethyltetradecylammonium bromide (cetrimonium bromide), dimethyldodecylbenzylammonium 15mum halide (benzododecinium halide), dimethylhexadecylbenzylammonium chloride (cetalkonium chloride), dodecyldimethyl 2-phenyloxyethylammonium bromide (phenododecinyl bromide) and benzyldimethyl (C5 -C8 alkyl) -ammonium chloride (benzalkonium chloride).

Preferred polyethylene glycol ethers are, for example:

tetraethylene glycol lauryl ether (Brij 30), diethylene glycol theateyl ether (Brij 72), diethylene glycol oleyl ether (Brij 92), diethylene glycol cotyl ether (Brij 52), polyethylene -glycol lauryl ether (degree of polymerization 23, Brij 35), polyethylene glycol Aztearyl ether (degree of polymerization 10, Brij,

76; degree of polymerization 20, Brij 78), polyethylene glycol oleyl ether (degree of polymerization 10, Brij 96; degree of polymerization 20, Brij 98), polyelylene glycol cetyl ether (degree of polymerization 10, Brij 56; degree of polymerization 20, Brij 58) etc.

the diluent is a diluent commonly used in disinfectant formulations, preferably one or more polyethylene glycols, for example, polyethylene glycol having a molecular weight of 300 to 35,000, or a mixture thereof, water, propylene glycol or glycerol. The composition according to the invention may contain a variety of diluents.

The additive that is present in the desired diet may be, for example, one or more ezines and / or one or more fragrances normally used in disinfectant compositions.

The composition of the invention is prepared by mixing the ingredients. The mixing is generally carried out at 20-100'C, preferably 60-90'C. In the case where the diluents are chosen so that the composition is in liquid form, it will be dispensed into a suitable container such as bottles of 1 liter. If a suitable composition of diluents is obtained, a solid composition is formed by mixing the ingredients in a melt, generally at 60-90 ° C, and filling the melt into suitable θθ molds, then cooling or allowing the contents of the molds to solidify and remove pieces from the molds. packaged. It is also possible to use molds which also serve as packaging means. In this case, there is no need to remove the solidified pieces, but the mold is sealed or packaged after the molded product has solidified.

The disinfectant composition of the present invention may also be referred to as solid or liquid soap. However, it goes without saying that this case is not soap in the conventional sense - the alkali metal salt of fatty acids.

The superior disinfectant effect of the composition of the present invention is demonstrated by an in situ disinfectant assay. The tests were performed in accordance with the requirements of Sectoral Standard 2 MSz-03 67 / 1-79. The methods used to determine the extent to which the test preparation destroys bacterial flora on the skin of the hand.

For each formulation, 33 fingertips in each hand (i.e., 50 hands) were infected with 0.1-0.1 ml of an 18-20 hour bouillon culture of the Escherichia coli HNCMB bacterial strain (10 * -10 * ml of the culturing unit). ), and the culture was rubbed into the skin for 1 minute. The infected hands were then rinsed with the test composition for 30 seconds and rinsed with running water at 37 ° G for 5 seconds, and the fingertip was sampled with 3 ml of 20 ml of inactivated petri dish in a sterile petri dish. soaked in bouillon medium containing blood serum for 1 minute. The culture medium samples eosin methylene blue selective solid media surface and szélesztettúk 37 ^e C for 48 hours incubated, followed by the determination of E. coli colony count agar plate. A preparation is considered to be a hygienic hand disinfectant if the mean number of colonies of cultured Escherichia coli from a minimum of 50% of the tested hands is between 0 and 10 colonies and the preparation has a bactericidal effect equal to that of a control of 60 tf X-oe isopropanol beyond that.

The disinfectant activity of various compounds of the formula I, various polyethylene glycol ethers and combinations thereof according to the invention is shown.

Table I. The percent disinfection effect was obtained by dividing the number of test hands obtained by culturing a sample of post-treatment with 0-10 Escherichia coli colonies per agar plate by the number of hands agar agar at the post-treatment sample. 11-100 Escherichia coli colonies per plate were obtained and the quotient was multiplied by 100.

Table I

Disinfectant effect X Compounds of Formula I: cetrimonium bromide 11 benzododecinium chloride 9 cetalkónium chloride 12 fenododecinium bromide 10 benzalkonium chloride 12 Polyethylene glycol ethers: Brij 30 (POE / 4 / lauryl ether) 0 Brij 35 (POE / 23 /-lauryl ether) 0 Brij 72 (POE / 2 / stearyl ether) 0 Brij 96 (POE / 10 / -oleyl ether) 0 Brij 58 (POE 20 / -acetyl ether) 0 Preparations of the invention cetrimonium bromide + Brij 58 80 benzododecinium chloride + Brij 35 82 cetalkonium chloride + Brij 96 79 phenododecinium bromide + Brij 72 83 benzalkonium chloride + Brij 30 84

* The compounds were tested at 20% by weight in the presence of 36% by weight of propylene glycol, 21% by weight of polyethylene glycol (molecular weight 6000), 21% by weight polyethylene glycol (molecular weight 3500) and 2% by weight solution of fuchsin (0.01x propylene glycol solution). .

“Polyethylene glycol ethers were tested at 5% by weight of 51% by weight of propylene glycol, 21% by weight of polyethylene glycol (molecular weight 6000), 21% by weight polyethylene glycol (3500 molecular weight) and 2% by weight solution of fuchsin (0.01% propylene glycol). solution).

"* Compositions of the test compositions: 20% by weight of a compound of formula I, 5% by weight of polyethylene glycol ether, 31% by weight of propylene glycol, 21% by weight of polyethylene glycol (molecular weight 6000), 21% by weight polyethylene glycol (molecular weight 3500) and 2% by weight of fuchsin solution (0.01% propylene glycol solution).

It is clear from the data in Table 1 that formulations containing only the compound of formula (I) provide only 9-12% hand disinfection and are therefore not hygienic disinfectants according to the above standard. Formulations containing only poly (III) glycol ethers have no antiseptic effect (they have a certain cleaning effect, but a single hand is available in Escherichia coli colonies between 0 and 10). 84%, which is also significantly higher than the control 60% by volume of isopropanol,

It is clear from the above test data that the polyethylene glycol ethers used in the composition of the invention greatly potentiate the disinfectant activity of the compounds of formula (I).

As shown in Table 1, the present invention disinfectant composition is highly effective in removing and killing infectious bacteria on the boron surface of the body. The preparation is easy to prepare.

The invention is illustrated in detail by the following examples.

Example 2 kg of benzalkonium chloride, 0.5 kg of tetraethylene glycol lauryl ether (Brij 30), 3.1 kg of propylene glycol, 2.1 kg of polyethylene glycol (molecular weight 6000, Carbowax 6000) and 2.1 kg of polyethylene -glycol (molecular weight 35,000, Carbowax 35,000) is melt-melted at temperatures below 90 ° C, the molten homogeneous massage is passed through a 120 mesh plastic sieve, mixed at 70-75 ° C with 0.2 kg of 0.01% propylene glycolic fuchsin solution and the mass is poured into plastic molds. After cooling, the molds containing the solidified composition, soap, are sealed with a self-adhesive film after about 30 minutes.

Example 2 kg of glycerol, 2 kg of benzalkonium chloride, 1 kg of tetraethylene glycol lauryl ether (Brij 30) and 6 kg of polyethylene glycol (molecular weight 300, Carbowax 300) were melt melted at 70-75 ° C to give a liquid. passed through a 120 mesh plastic sieve and filled into 1000 ml plastic bottles. After cooling, the preparation can be used as liquid soap.

Example 3

Solid soap was prepared as described in Example 1 from the following components:

cetrimonium bromide, 15 parts benzalkonium chloride, 4 parts polyethylene glycol lauryl ether (degree of polymerization 23, Brij 35), 18 parts polyethylene glycol (molecular weight 6000), 18 parts polyethylene glycol (molecular weight 35 000) 30 parts by weight of propylene glycol.

Ί. example

The procedure described in Example 3 was followed except that the polyethylene glycol ethers were used instead of the polyethylene glycol lauryl ether:

(a) polyethylene glycol oleyl ether (p -. 'limerizers'. 10B degree 20, Brij 98),

b) polyethylene glycol ethyl ether (pi> 1 degree of immersion 20, Brij 58).

Example 5

The procedure described in Example 1 was followed, however, with the following components being made into solid soap:

benzododecinium chloride, 20 parts polyethylene glycol (molecular weight 6,000), 20 parts polyethylene glycol (molecular weight 35,000), 26 parts propylene glycol, 4 parts polyethylene glycol lauryl ether (degree of polymerization 23, Brij 35).

Example 6

The procedure described in Example 1 was followed except that phenododecinium bromide was substituted for benzalkonium chloride and diethylene glycol stearyl ether (Brij 72) instead of tetraethylene glycol lauryl ether.

Example 7

Liquid soap was prepared as described in Example 2 from 10 parts by weight of polyethylene glycol cetyl ether (degree of polymerisation 20, Brij 58), 20 parts by weight of cetrimonium bromide, 69.9 parts by weight of glycerol and 0.1 parts by weight of perfume.

Example 8

Liquid soap was prepared as described in Example 2 from the following components:

parts by weight of polyethylene glycol oleyl ether (degree of polymerization 10, Brij 96), 20 parts by weight of cetalkonium chloride, 59.9 parts by weight of polyethylene glycol (molecular weight 300), 10 parts by weight glycerol and 0.1 parts by weight fragrance.

Example 9

The procedure described in Example 8 was followed except that polyethylene glycol (molecular weight 300) was used instead of glycerol.

192 385

Example 10

The procedure described in Example 1 was followed except that, instead of benzalkonium chloride, cetrimonium bronide was used and the following polyethylene glycol ethers were used instead of tetraethylene glycol lauryl ether:

(a) diethylene glycol-thearyl ether (Brij 72).

b) diethylene glycol oleyl ether (Brij 92).

c) diethylene glycol cetyl ether (Brij 52).

d) polyethylene glycol stearyl ether (degree 10 polymerization, Brij 76).

e) Polyethylene glycol Aztearyl ether (degree 20 polymerization, Brij 78).

f) polyethylene glycol oleyl ether (degree of polymerization 10, Brij 96).

g) polyethylene glycol cetyl ether (degree of polymerization 20, Brij 58) ^zu

Example 11

Example 2 Ezerine was prepared as a liquid soap from 10 parts by weight of benzalkonium chloride, 10 parts by weight of glycerol, 70 parts by weight of distilled water and 10 parts by weight of tetraethylene glycol lauryl ether (Brij "30).

Example 12

As described in Example 2, a liquid disinfectant is prepared from the following ingredients:

part by weight benzalkonium chloride, 1 part by weight tetraethylene glycol lauryl ether (Brij 30), part by weight glycerol and 73 parts by weight distilled water.

Example 13

Example 2 is made up of a liquid disinfectant consisting of 35 parts by weight of benzalkonium chloride, 20 parts by weight of tetraethylene glycol lauryl ether (Brij 30), 8 parts by weight of glycerol and 37 parts by weight of distilled water.

Claims (7)

A disinfectant composition comprising 0.5 to 35% by weight of one or more compounds of formula (I) wherein Ar is benzyl, (C 1 -C 4) alkyl or phonooxy (C 1 -C 3) alkyl; R 1 and R 10 are methyl, R 1 is C 6 -C 18 alkyl, X is halogen, preferably chloride or bromide, in an amount of 1 to 20% by weight of one or more polyelylene glycol alkyl or alkenyl ethers, wherein polyethylene glycol is. has a degree of polymerization of 2 to 23 and the alkyl or alkenyl group contains from 10 to 20 carbon atoms, from 40 to 80% by weight of customary diluent (s) and from 0 to 10% by weight of conventional additives / materials. 2. The disinfectant according to claim 1, wherein the compound of formula (I) is benzyldimethyl- (C 1-4 alkyl) ammonium chloride. 3. The disinfectant according to claim 1, wherein the polyethylene glycol alkyl ether is tetraethylene glycol lauryl ether. 4. A process for the preparation of a disinfectant composition comprising 0.5 to 35% by weight of one or more compounds of formula I wherein Ar is benzyl, C 1-4 alkyl or phenoxy (C 1-3 alkyl) -. R 1 is methyl, R 6 is C 6 -C 18 alkyl, X is halogen, preferably chloride or bromide, in an amount of 1 to 20% by weight of one or more polyethylene glycol alkyl or alkonyl esters wherein the polyethylene the glycol has a degree of polymerization of 2 to 23 and the alkyl or alkenyl group is mixed with 10 to 20 carbon atoms of a conventional diluent (s) and 10 to 10 weight percent of conventional diluent (s) at 20 to 100 ° C and optionally shaped . The method of claim 4, wherein characterized in that benzyldimethyl (C 1-6 alkyl) ammonium chloride is used as the compound of formula (I). 6. A process according to claim 4 wherein the polyethylene glycol alkyl ether is tetraethylene glycol lauryl ether. The method of claim 4 for preparing a solid disinfectant composition, wherein the mixture is suitably at a temperature of 50-90 ° C and is cooled to room temperature.