[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

HU0101334D0 - New process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]thiazepine and use thereof for the synthesis of tianeptine - Google Patents

New process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]thiazepine and use thereof for the synthesis of tianeptine

Info

Publication number
HU0101334D0
HU0101334D0 HU0101334A HUP0101334A HU0101334D0 HU 0101334 D0 HU0101334 D0 HU 0101334D0 HU 0101334 A HU0101334 A HU 0101334A HU P0101334 A HUP0101334 A HU P0101334A HU 0101334 D0 HU0101334 D0 HU 0101334D0
Authority
HU
Hungary
Prior art keywords
tianeptine
thiazepine
dibenzo
dioxo
dihydro
Prior art date
Application number
HU0101334A
Other languages
English (en)
Inventor
Jacky Blanchard
Daniel Brigot
Hugues Turbe
Original Assignee
Adir Et Cie Adir Et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir Et Cie Adir Et Cie filed Critical Adir Et Cie Adir Et Cie
Publication of HU0101334D0 publication Critical patent/HU0101334D0/hu
Publication of HUP0101334A2 publication Critical patent/HUP0101334A2/hu
Publication of HUP0101334A3 publication Critical patent/HUP0101334A3/hu
Publication of HU228204B1 publication Critical patent/HU228204B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HU0101334A 2000-03-31 2001-03-30 New process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]thiazepine and use thereof for the synthesis of tianeptine HU228204B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0004111A FR2807039A1 (fr) 2000-03-31 2000-03-31 NOUVEAU PROCEDE DE PREPARATION DE LA 11-AMINO-3-CHLORO-6,11- DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO[c,f][1,2]-THIAZEPINE ET APPLICATION A LA SYNTHESE DE LA TIANEPTINE

Publications (4)

Publication Number Publication Date
HU0101334D0 true HU0101334D0 (en) 2001-06-28
HUP0101334A2 HUP0101334A2 (hu) 2002-03-28
HUP0101334A3 HUP0101334A3 (en) 2004-11-29
HU228204B1 HU228204B1 (en) 2013-01-28

Family

ID=8848710

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101334A HU228204B1 (en) 2000-03-31 2001-03-30 New process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]thiazepine and use thereof for the synthesis of tianeptine

Country Status (23)

Country Link
US (1) US6441165B2 (hu)
EP (1) EP1138677B1 (hu)
JP (1) JP3723464B2 (hu)
KR (1) KR100464180B1 (hu)
CN (1) CN1157387C (hu)
AR (1) AR028306A1 (hu)
AT (1) ATE242226T1 (hu)
AU (1) AU777616B2 (hu)
BR (1) BR0101230B1 (hu)
CA (1) CA2342950C (hu)
DE (1) DE60100321T2 (hu)
DK (1) DK1138677T3 (hu)
EA (1) EA003770B1 (hu)
ES (1) ES2201019T3 (hu)
FR (1) FR2807039A1 (hu)
HK (1) HK1039618B (hu)
HU (1) HU228204B1 (hu)
NO (1) NO318088B1 (hu)
NZ (1) NZ510857A (hu)
PL (1) PL212886B1 (hu)
PT (1) PT1138677E (hu)
SI (1) SI1138677T1 (hu)
ZA (1) ZA200102642B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683072B1 (en) * 2003-02-04 2004-01-27 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia
JP5599974B2 (ja) * 2005-10-17 2014-10-01 ジェネリクス・［ユーケー］・リミテッド 新規な方法
US9314469B2 (en) 2008-05-05 2016-04-19 Tonix Pharma Holdings Limited Method for treating neurocognitive dysfunction
US8198268B2 (en) 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
WO2010070667A2 (en) * 2008-11-19 2010-06-24 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate
KR101136976B1 (ko) * 2011-09-06 2012-05-30 건일제약 주식회사 티아넵틴 또는 그의 염을 포함하는 탈모증의 예방 또는 치료용 약학 조성물
GB201208315D0 (en) 2012-05-11 2012-06-27 Numedicus Ltd Pharmaceutical methods and compositions
WO2017049158A1 (en) 2015-09-16 2017-03-23 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
CN105254587B (zh) * 2015-10-21 2018-01-09 济南诚汇双达化工有限公司 一种噻萘普汀钠中间体的制备方法
WO2017165738A1 (en) 2016-03-25 2017-09-28 The Trustees Of Columbia University In The City Of New York Mitragynine alkaloids as opioid receptor modulators
US11787772B2 (en) 2017-03-15 2023-10-17 The Trustees Of Columbia University In The City Of New York Carboxylic diarythiazepineamines as mixed mu- and delta-opioid receptor agonists
CN110790723A (zh) * 2018-08-02 2020-02-14 北京万全德众医药生物技术有限公司 噻奈普汀钠的合成方法
KR20180101307A (ko) 2018-09-04 2018-09-12 지엘팜텍주식회사 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제
KR102199871B1 (ko) 2018-12-21 2021-01-08 주식회사 한서켐 3,11-디클로로-6-메틸-6,11-디하이드로디벤조[c,f][1,2]티아제핀 5,5-디옥시드의 제조방법
KR20200104265A (ko) 2020-08-21 2020-09-03 지엘팜텍주식회사 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제
CN112062733A (zh) * 2020-10-30 2020-12-11 南京法恩化学有限公司 一种噻萘普汀钠的制备方法
CN115819375A (zh) * 2022-12-25 2023-03-21 山东诚汇双达药业有限公司 噻奈普汀钠关键中间体的制备方法
CN115872951A (zh) * 2022-12-25 2023-03-31 山东诚汇双达药业有限公司 一种噻奈普汀钠中间体甲氧基取代物的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1179108A (en) * 1966-12-19 1970-01-28 Science Union & Cie New Derivatives of Dibenzo (c,f) Thiazepine (1,2) and processes for manufacturing them
GB1269551A (en) 1969-03-27 1972-04-06 Science Union & Cie New tricyclic derivatives and process for their manufacture
CA995213A (fr) * 1972-03-16 1976-08-17 Charles Malen Procede de preparation de derives tricycliques
PL106752B1 (pl) * 1976-02-25 1980-01-31 Politechnika Gdanska Sposob otrzymywania nowych 1-nitro-9-alkiloaminoalkiloaminoakrydyn lub ich soli
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
KR890002073A (ko) * 1987-07-01 1989-04-07 원본미기재 나프토티아제핀온
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
JPH05255290A (ja) * 1992-03-17 1993-10-05 Fujisawa Pharmaceut Co Ltd 腫瘍壊死因子産生阻害剤
FR2716623B1 (fr) * 1994-02-25 1996-08-23 Adir Utilisation d'un dérivé tricyclique pour l'obtention de médicaments destinés au traitement des troubles mnémo-cognitifs.
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5886185A (en) * 1997-11-20 1999-03-23 Development Center For Biotechnoloy Polyamine-linked acridine dimers
GB2339778A (en) * 1998-07-17 2000-02-09 Secr Defence Terphenyl Liquid Crystals

Also Published As

Publication number Publication date
CN1157387C (zh) 2004-07-14
PL346793A1 (en) 2001-10-08
CA2342950A1 (fr) 2001-09-30
EA200100301A2 (ru) 2001-10-22
AU3336801A (en) 2001-10-04
NO318088B1 (no) 2005-01-31
HK1039618B (zh) 2004-12-31
EP1138677B1 (fr) 2003-06-04
HK1039618A1 (en) 2002-05-03
AR028306A1 (es) 2003-05-07
PL212886B1 (pl) 2012-12-31
EP1138677A1 (fr) 2001-10-04
NZ510857A (en) 2001-08-31
NO20011598L (no) 2001-10-01
BR0101230A (pt) 2001-10-30
ES2201019T3 (es) 2004-03-16
DE60100321D1 (de) 2003-07-10
NO20011598D0 (no) 2001-03-29
EA200100301A3 (ru) 2001-12-24
EA003770B1 (ru) 2003-08-28
AU777616B2 (en) 2004-10-21
ZA200102642B (en) 2001-10-05
US6441165B2 (en) 2002-08-27
HUP0101334A3 (en) 2004-11-29
KR100464180B1 (ko) 2004-12-31
US20010037021A1 (en) 2001-11-01
HU228204B1 (en) 2013-01-28
JP3723464B2 (ja) 2005-12-07
JP2001316380A (ja) 2001-11-13
SI1138677T1 (en) 2003-10-31
CN1319593A (zh) 2001-10-31
KR20010095040A (ko) 2001-11-03
HUP0101334A2 (hu) 2002-03-28
CA2342950C (fr) 2007-05-08
BR0101230B1 (pt) 2013-12-24
DE60100321T2 (de) 2004-04-29
PT1138677E (pt) 2003-09-30
DK1138677T3 (da) 2003-09-29
ATE242226T1 (de) 2003-06-15
FR2807039A1 (fr) 2001-10-05

Similar Documents

Publication Publication Date Title
HU0101334D0 (en) New process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]thiazepine and use thereof for the synthesis of tianeptine
HK1089447A1 (en) A process for the preparation of 2-aminocarbonyl-9h-purine derivatives and the intermediates thereof
GB0117095D0 (en) "Process for the preparation of pure citalopram"
IL149592A0 (en) Synthesis of 2'-deoxy-l-nucleosides
CZ20011657A3 (cs) Nové piperazinové a piperidinové sloučeniny, způsob jejich přípravy a jejich pouľití
IL147503A0 (en) Oxazolidinone compounds and methods of preparation and use thereof
CZ20012130A3 (cs) Piperazinový derivát, způsob jeho výroby a pouľití
IL159067A0 (en) METHODS FOR PREPARATION AND USE OF 1alpha,24 (S) -DIHYDROXYVITAMIN D2
GB0026837D0 (en) Process for the preparation of dental prosthesis
IL126426A0 (en) Process for the preparation of corroles several such new compounds including chiral derivatives and the use thereof
HUP9902783A3 (en) Polymorph of zopolrestat monohydrate, process for it's preparation and therapical use of the same
HUP0302344A3 (en) A process for the preparation of alpha-n-acyl alpha' chloroketones
PL357106A1 (en) Novel process for the preparation of alpha-(2-4-disulfophenyl)-n-tert-butylnitrone and pharmaceutically acceptable salts thereof
HUP0203384A3 (en) Process for the preparation of ketimines
AU2001277801A1 (en) Process for preparing 2,3-diaminopropanols and synthesis of other compounds using 2,3-diaminopropanols
AU5553200A (en) Process for the preparation of paroxetine and structurally related compounds
IL149527A0 (en) Process for the preparation of ketimines
HUP0103569A3 (en) New medicament and process for its preparation
AU2712999A (en) Use of hexapeptides for the manufacture of a pharmaceutical composition for the treatment of hot flushes
HUP9900761A3 (en) A process for the preparation of 4-(desdimethyl-amino)-tetracyclines
AU3060500A (en) 1,4-diazacycloheptane compounds, process for their preparation, and their use asmedicaments
HUP0201610A3 (en) Derivatives of 4'-demycarosyl-8a-aza-8a-homotylosin
HUP0102297A3 (en) Process for preparation of 4,5-epoxymorphinan-6-oxi-glucuronides
IL132524A0 (en) Crystalline form of nefazodone and process for the preparation thereof
HUP0201181A3 (en) 1,5-benzodiazepine derivatives, process for producing it and pharmaceutical composition containing it

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees