HRP960054B1 - A process for preparing certain aza cyclohexapeptides - Google Patents

A process for preparing certain aza cyclohexapeptides

Info

Publication number: HRP960054B1
Authority: HR; Croatia
Prior art keywords: formula; compound; borane complex; nabh4; metal boride
Prior art date: 1995-02-10

Application number

HR960054A

Other languages

English (en)

Croatian (hr)

Inventor

M. Belyk Kevin

R. Bender Dean

M. Black Regina

L. Hughes David

Leonard William

Original Assignee

Merck & Co. Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-10

Filing date

1996-02-05

Publication date

2008-07-31

1996-02-05 Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.

1997-10-31 Publication of HRP960054A2 publication Critical patent/HRP960054A2/hr

2008-07-31 Publication of HRP960054B1 publication Critical patent/HRP960054B1/xx

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 abstract 5
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 abstract 3
229910000085 borane Inorganic materials 0.000 abstract 3
RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 abstract 3
FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
239000012279 sodium borohydride Substances 0.000 abstract 2
229910000033 sodium borohydride Inorganic materials 0.000 abstract 2
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
229910003074 TiCl4 Inorganic materials 0.000 abstract 1
229910007932 ZrCl4 Inorganic materials 0.000 abstract 1
125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
UORVGPXVDQYIDP-BJUDXGSMSA-N borane Chemical group [10BH3] UORVGPXVDQYIDP-BJUDXGSMSA-N 0.000 abstract 1
AIISXRKIVYOASZ-UHFFFAOYSA-N methylsulfanylmethane phenylsulfanylbenzene Chemical compound CSC.C1(=CC=CC=C1)SC1=CC=CC=C1 AIISXRKIVYOASZ-UHFFFAOYSA-N 0.000 abstract 1
125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 abstract 1
DUNKXUFBGCUVQW-UHFFFAOYSA-J zirconium tetrachloride Chemical group Cl[Zr](Cl)(Cl)Cl DUNKXUFBGCUVQW-UHFFFAOYSA-J 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06114—Packages or dispensers for needles or sutures
- A61B17/06133—Packages or dispensers for needles or sutures of parallelepipedal shape, e.g. made of rectangular or slightly oval panels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06114—Packages or dispensers for needles or sutures
- A61B2017/06142—Packages or dispensers for needles or sutures having needle- or suture- retaining members, e.g. holding tabs or needle parks
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Surgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Dentistry (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medical Informatics (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HR960054A 1995-02-10 1996-02-05 A process for preparing certain aza cyclohexapeptides HRP960054B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/386,618 US5552521A (en)	1995-02-10	1995-02-10	Process for preparing certain aza cyclohexapeptides

Publications (2)

Publication Number	Publication Date
HRP960054A2 HRP960054A2 (en)	1997-10-31
HRP960054B1 true HRP960054B1 (en)	2008-07-31

Family

ID=23526350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR960054A HRP960054B1 (en)	1995-02-10	1996-02-05	A process for preparing certain aza cyclohexapeptides

Country Status (21)

Country	Link
US (1)	US5552521A (sh)
EP (1)	EP0808330B1 (sh)
CN (1)	CN1127515C (sh)
AR (2)	AR001081A1 (sh)
AT (1)	ATE309266T1 (sh)
AU (1)	AU692071B2 (sh)
BR (1)	BR9607721A (sh)
CA (1)	CA2211314C (sh)
CZ (2)	CZ286683B6 (sh)
DE (1)	DE69635405T2 (sh)
EA (1)	EA000564B1 (sh)
ES (1)	ES2249778T3 (sh)
FI (1)	FI120693B (sh)
HK (1)	HK1004676A1 (sh)
HR (1)	HRP960054B1 (sh)
HU (1)	HU229780B1 (sh)
NZ (1)	NZ302967A (sh)
SK (1)	SK283115B6 (sh)
TW (1)	TW515805B (sh)
WO (1)	WO1996024613A1 (sh)
YU (1)	YU49459B (sh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0779895B1 (en) *	1994-08-23	1999-11-17	Merck & Co. Inc.	An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
ATE223226T1 (de) *	1994-09-16	2002-09-15	Merck & Co Inc	Azazyklohexapeptid-verbindungen
US5952300A (en) *	1996-04-19	1999-09-14	Merck & Co., Inc.	Antifungal compositions
HRP970318B1 (en) *	1996-06-14	2002-06-30	Merck & Co Inc	A process for preparing certain aza cyclohexapeptides
USRE38984E1 (en) *	1996-09-12	2006-02-14	Merck & Co., Inc.	Antifungal combination therapy
US5936062A (en) *	1997-06-12	1999-08-10	Merck & Co., Inc.	Process for preparing certain aza cyclohexapeptides
WO2000024694A1 (en) *	1998-10-28	2000-05-04	Eli Lilly And Company	Photochemical process for making 1-deoxy-2-keto derivatives
AR035808A1 (es) *	2001-04-12	2004-07-14	Merck & Co Inc	Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
US7214768B2 (en) *	2002-04-08	2007-05-08	Merck & Co., Inc.	Echinocandin process
EP1785432A1 (en) *	2005-11-15	2007-05-16	Sandoz AG	Process and intermediates for the synthesis of caspofungin.
JP5373606B2 (ja)	2006-07-26	2013-12-18	サンド・アクチエンゲゼルシヤフト	カスポファンギン製剤
US20100137197A1 (en) *	2007-06-26	2010-06-03	Sachin Mittal	Lyophilized anti-fungal composition
US20090075870A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched caspofungin
WO2009142761A1 (en) *	2008-05-21	2009-11-26	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Caspofungin bo free of caspofungin co
US8048853B2 (en)	2008-06-13	2011-11-01	Xellia Pharmaceuticals Aps	Process for preparing pharmaceutical compound and intermediates thereof
KR20110011704A (ko) *	2008-06-25	2011-02-08	테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그	카스포펀진 불순물 ａ를 함유하지 않는 카스포펀진
EP2240507A2 (en) *	2008-06-25	2010-10-20	TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Processes for preparing high purity aza cyclohexapeptides
WO2010064219A1 (en)	2008-12-04	2010-06-10	Ranbaxy Laboratories Limited	Process for the preparation of a novel intermediate for caspofungin
EP2463293A4 (en) *	2009-08-06	2013-06-05	Shanghai Techwell Biopharm Co	AZACYCLOHEXAPEPTIDE BZW. ITS PHARMACEUTICAL ACCEPTABLE SALT, MANUFACTURING PROCESS AND USE
CN101792486A (zh) *	2010-04-12	2010-08-04	浙江海正药业股份有限公司	一种合成醋酸卡泊芬净的方法
CN102219832B (zh) *	2010-04-15	2013-08-21	上海天伟生物制药有限公司	一种氮杂环六肽或其盐的纯化方法
CN103180336B (zh)	2010-09-28	2016-06-15	中化帝斯曼制药有限公司荷兰公司	用于分离环六肽的方法
US8927690B2 (en) *	2010-09-29	2015-01-06	Shanghai Techwell Biopharmaceutical Co., Ltd.	Process for purifying cyclolipopeptide compounds or the salts thereof
CN102367269B (zh) *	2010-11-10	2013-11-06	上海天伟生物制药有限公司	一种卡泊芬净类似物及其制备方法和用途
CN102367268B (zh) *	2010-11-10	2013-11-06	上海天伟生物制药有限公司	一种卡泊芬净类似物及其用途
CN102367267B (zh) *	2010-11-10	2013-09-04	上海天伟生物制药有限公司	一种卡泊芬净的制备方法
KR101331984B1 (ko)	2010-12-09	2013-11-25	종근당바이오 주식회사	카스포펀진 제조방법 및 그의 신규 중간체
CN102219833A (zh) *	2011-04-18	2011-10-19	深圳市健元医药科技有限公司	一种更加安全的棘白菌类抗真菌药的制备方法
CN102746384B (zh) *	2011-04-22	2016-01-20	上海天伟生物制药有限公司	一种高纯度的卡泊芬净或其盐及其制备方法和用途
US9321779B2 (en) *	2011-04-28	2016-04-26	Unitris Biopharma Co., Ltd.	Intermediate for synthesizing caspofungin and preparation method thereof
CN103483426A (zh) *	2012-06-14	2014-01-01	博瑞生物医药技术(苏州)有限公司	一种氮杂环己肽的制备方法
US9636407B2 (en)	2012-11-20	2017-05-02	Fresenius Kabi Usa, Llc	Caspofungin acetate formulations
EP3620462A1 (en)	2018-09-04	2020-03-11	Xellia Pharmaceuticals ApS	Process for the preparation of caspofungin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2704030A1 (de) *	1976-02-12	1977-08-18	Sandoz Ag	Neue organische verbindungen, ihre herstellung und verwendung
IE910892A1 (en) *	1990-03-19	1991-09-25	Merck & Co Inc	Lipopeptide compounds
US5939384A (en) *	1991-10-01	1999-08-17	Merck & Co., Inc.	Cyclohexapeptidyl propanolamine compounds
US5378804A (en) *	1993-03-16	1995-01-03	Merck & Co., Inc.	Aza cyclohexapeptide compounds
US6268338B1 (en) *	1993-04-30	2001-07-31	Merck & Co., Inc.	Cyclohexapeptidyl amine compounds
EP0779895B1 (en) *	1994-08-23	1999-11-17	Merck & Co. Inc.	An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
ATE223226T1 (de) *	1994-09-16	2002-09-15	Merck & Co Inc	Azazyklohexapeptid-verbindungen

1995
- 1995-02-10 US US08/386,618 patent/US5552521A/en not_active Expired - Lifetime
1996
- 1996-02-01 TW TW085101244A patent/TW515805B/zh not_active IP Right Cessation
- 1996-02-05 HR HR960054A patent/HRP960054B1/xx not_active IP Right Cessation
- 1996-02-06 BR BR9607721A patent/BR9607721A/pt not_active Application Discontinuation
- 1996-02-06 CZ CZ19972525A patent/CZ286683B6/cs not_active IP Right Cessation
- 1996-02-06 DE DE69635405T patent/DE69635405T2/de not_active Expired - Lifetime
- 1996-02-06 CN CN96191834A patent/CN1127515C/zh not_active Expired - Lifetime
- 1996-02-06 NZ NZ302967A patent/NZ302967A/en not_active IP Right Cessation
- 1996-02-06 WO PCT/US1996/001523 patent/WO1996024613A1/en active IP Right Grant
- 1996-02-06 CA CA002211314A patent/CA2211314C/en not_active Expired - Lifetime
- 1996-02-06 EP EP96905366A patent/EP0808330B1/en not_active Expired - Lifetime
- 1996-02-06 HU HU9901085A patent/HU229780B1/hu unknown
- 1996-02-06 SK SK1079-97A patent/SK283115B6/sk not_active IP Right Cessation
- 1996-02-06 EA EA199700170A patent/EA000564B1/ru not_active IP Right Cessation
- 1996-02-06 ES ES96905366T patent/ES2249778T3/es not_active Expired - Lifetime
- 1996-02-06 AT AT96905366T patent/ATE309266T1/de active
- 1996-02-06 AU AU49147/96A patent/AU692071B2/en not_active Expired
- 1996-02-07 AR AR33533596A patent/AR001081A1/es unknown
- 1996-02-09 YU YU8496A patent/YU49459B/sh unknown
1997
- 1997-01-14 AR ARP970100139A patent/AR005462A1/es not_active Application Discontinuation
- 1997-08-08 FI FI973281A patent/FI120693B/fi not_active IP Right Cessation
1998
- 1998-05-06 HK HK98103878A patent/HK1004676A1/xx not_active IP Right Cessation
1999
- 1999-12-17 CZ CZ19994601A patent/CZ286767B6/cs not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2249778T3 (es)	2006-04-01
DE69635405D1 (de)	2005-12-15
CZ286683B6 (en)	2000-06-14
FI973281A (fi)	1997-08-08
EP0808330B1 (en)	2005-11-09
EP0808330A1 (en)	1997-11-26
FI120693B (fi)	2010-01-29
SK107997A3 (en)	1998-02-04
TW515805B (en)	2003-01-01
HRP960054A2 (en)	1997-10-31
HUP9901085A2 (hu)	1999-09-28
HUP9901085A3 (en)	2000-11-28
HU229780B1 (en)	2014-07-28
MX9706101A (es)	1997-10-31
BR9607721A (pt)	1998-07-14
CN1127515C (zh)	2003-11-12
DE69635405T2 (de)	2006-07-27
EA000564B1 (ru)	1999-12-29
YU49459B (sh)	2006-03-03
AU692071B2 (en)	1998-05-28
CA2211314C (en)	2007-04-17
ATE309266T1 (de)	2005-11-15
YU8496A (sh)	1999-06-15
NZ302967A (en)	1998-11-25
WO1996024613A1 (en)	1996-08-15
SK283115B6 (sk)	2003-02-04
CZ252597A3 (cs)	1998-01-14
AR001081A1 (es)	1997-09-24
AR005462A1 (es)	1999-06-23
AU4914796A (en)	1996-08-27
CA2211314A1 (en)	1996-08-15
CZ286767B6 (cs)	2000-06-14
FI973281A0 (fi)	1997-08-08
CN1173875A (zh)	1998-02-18
US5552521A (en)	1996-09-03
EA199700170A1 (ru)	1997-12-30
HK1004676A1 (en)	1998-12-04

Publication	Publication Date	Title
HRP960054B1 (en)	2008-07-31	A process for preparing certain aza cyclohexapeptides
MA21601A1 (fr)	1990-04-01	Procede d'alcoylation de 2-amino-purines et intermediaires utiles a cet effet .
AU528275B2 (en)	1983-04-21	Imidazole derivatives
EP0921417A3 (en)	2002-04-10	Epoxy/episulfide resin compositions for optical materials
HUT71499A (en)	1995-11-28	Bicyclo[2.2.2.]octane derivatives pharmaceutical compositions contg. the said compounds and process to prepare them
ES8503667A1 (es)	1985-03-16	Un procedimiento para la preparacion de nuevos derivados de 2-oxo-imidazolina.
ES8305764A1 (es)	1983-04-16	Un procedimiento para la preparacion de derivados carbapenen-2-tio-sustituidos.
NZ332798A (en)	2000-05-26	A process for preparing aza cyclohexapeptides
TW328084B (en)	1998-03-11	Process for producing guanidine derivatives, intermediates therefor and their production
PL337016A1 (en)	2000-07-31	Stabilised carbapenemic intermediate compounds and their application in a synthesis process
WO2002092606A8 (fr)	2002-12-19	Derives d'imidazolidine fusionnes, leur procede de preparation et d'utilisation
TW353660B (en)	1999-03-01	Novel diarylmethylidenefuran derivatives, process for their preparation and their uses in therapeutics
IE39278B1 (en)	1978-09-13	Fluoro substituted phenothiazines method for preparation thereof and composaitions
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DE3265533D1 (en)	1985-09-26	7-alpha-alkoxycarbonyl-15-beta-16-beta-methylene-4 androstene, process for their preparation and their utilization as pharmaceutical preparations
HRP20000027B1 (en)	2006-07-31	Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds
DE68924991D1 (de)	1996-01-18	2-Pyranon-Derivat und Verfahren zu dessen Herstellung.
IE820486L (en)	1982-09-05	Piperazinoquinazoline antihypertensives.
Fasseur et al.	1990	Electrochemical synthesis of the vinylogs of N-acyl N, O-acetals and their reactivity
Mochizuki et al.	1990	Preparation of Optically Pure (S)(+)-2-Oxothiazolidine-4-carboxylic Acid from a Racemate by Microbial Degradation of the (R)-Enantiomer
AU7480191A (en)	1991-10-10	3'-o-tosylcytidine and cytosine compounds, and process for production thereof
MY141464A (en)	2010-04-30	Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
YU90192A (sh)	1995-12-04	LANOSTA-7,9-DIEN-3β, 32-DIOL I POSTUPAK ZA NJEGOVO DOBIJANJE,9-DIEN-3BETA, 32-DIOL I POSTUPAK ZA NJEGOVU SINTEZU
TW353071B (en)	1999-02-21	Chromene compounds with neutroleptic activity, their preparation and pharmaceutical compositions
TW257749B (en)	1995-09-21	Process for producing polycyclic compounds

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