CZ252597A3 - Způsob výroby azacyklohexapeptidů - Google Patents

Způsob výroby azacyklohexapeptidů

Info

Publication number: CZ252597A3
Authority: CZ; Czechia
Prior art keywords: azacyclohexapeptides; preparing; preparing azacyclohexapeptides
Prior art date: 1995-02-10

Application number

CZ972525A

Other languages

English (en)

Other versions

CZ286683B6 (en

Inventor

Kevin M. Belyk

Dean R. Bender

Regina M. Black

David L. Hughes

William Leonard

Original Assignee

Merck & Co., Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-10

Filing date

1996-02-06

Publication date

1998-01-14

1996-02-06 Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.

1998-01-14 Publication of CZ252597A3 publication Critical patent/CZ252597A3/cs

2000-06-14 Publication of CZ286683B6 publication Critical patent/CZ286683B6/cs

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06114—Packages or dispensers for needles or sutures
- A61B17/06133—Packages or dispensers for needles or sutures of parallelepipedal shape, e.g. made of rectangular or slightly oval panels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06114—Packages or dispensers for needles or sutures
- A61B2017/06142—Packages or dispensers for needles or sutures having needle- or suture- retaining members, e.g. holding tabs or needle parks
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Surgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Medical Informatics (AREA)
Dentistry (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CZ19972525A 1995-02-10 1996-02-06 Process for preparing azacyclohexapeptides CZ286683B6 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/386,618 US5552521A (en)	1995-02-10	1995-02-10	Process for preparing certain aza cyclohexapeptides

Publications (2)

Publication Number	Publication Date
CZ252597A3 true CZ252597A3 (cs)	1998-01-14
CZ286683B6 CZ286683B6 (en)	2000-06-14

Family

ID=23526350

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CZ19972525A CZ286683B6 (en)	1995-02-10	1996-02-06	Process for preparing azacyclohexapeptides
CZ19994601A CZ286767B6 (cs)	1995-02-10	1999-12-17	Způsob výroby azacyklohexapeptidů

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CZ19994601A CZ286767B6 (cs)	1995-02-10	1999-12-17	Způsob výroby azacyklohexapeptidů

Country Status (21)

Country	Link
US (1)	US5552521A (cs)
EP (1)	EP0808330B1 (cs)
CN (1)	CN1127515C (cs)
AR (2)	AR001081A1 (cs)
AT (1)	ATE309266T1 (cs)
AU (1)	AU692071B2 (cs)
BR (1)	BR9607721A (cs)
CA (1)	CA2211314C (cs)
CZ (2)	CZ286683B6 (cs)
DE (1)	DE69635405T2 (cs)
EA (1)	EA000564B1 (cs)
ES (1)	ES2249778T3 (cs)
FI (1)	FI120693B (cs)
HK (1)	HK1004676A1 (cs)
HR (1)	HRP960054B1 (cs)
HU (1)	HU229780B1 (cs)
NZ (1)	NZ302967A (cs)
SK (1)	SK283115B6 (cs)
TW (1)	TW515805B (cs)
WO (1)	WO1996024613A1 (cs)
YU (1)	YU49459B (cs)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU692043B2 (en) *	1994-08-23	1998-05-28	Merck & Co., Inc.	An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
AU692308B2 (en) *	1994-09-16	1998-06-04	Merck Sharp & Dohme Corp.	Aza cyclohexapeptide compounds
US5952300A (en) *	1996-04-19	1999-09-14	Merck & Co., Inc.	Antifungal compositions
HRP970318B1 (en) *	1996-06-14	2002-06-30	Merck & Co Inc	A process for preparing certain aza cyclohexapeptides
USRE38984E1 (en) *	1996-09-12	2006-02-14	Merck & Co., Inc.	Antifungal combination therapy
US5936062A (en) *	1997-06-12	1999-08-10	Merck & Co., Inc.	Process for preparing certain aza cyclohexapeptides
WO2000024694A1 (en) *	1998-10-28	2000-05-04	Eli Lilly And Company	Photochemical process for making 1-deoxy-2-keto derivatives
AR035808A1 (es) *	2001-04-12	2004-07-14	Merck & Co Inc	Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
US7214768B2 (en) *	2002-04-08	2007-05-08	Merck & Co., Inc.	Echinocandin process
EP1785432A1 (en) *	2005-11-15	2007-05-16	Sandoz AG	Process and intermediates for the synthesis of caspofungin.
BRPI0715113A2 (pt)	2006-07-26	2013-06-04	Sandoz Ag Sandoz Sa Sandoz Ltd	formulaÇço de caspofungina
EP2170362B1 (en) *	2007-06-26	2015-11-04	Merck Sharp & Dohme Corp.	Lyophilized anti-fungal composition
US20090075870A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched caspofungin
WO2009142761A1 (en) *	2008-05-21	2009-11-26	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Caspofungin bo free of caspofungin co
US8048853B2 (en)	2008-06-13	2011-11-01	Xellia Pharmaceuticals Aps	Process for preparing pharmaceutical compound and intermediates thereof
US20100256074A1 (en) *	2008-06-25	2010-10-07	Chaim Eidelman	Processes for preparing high purity aza cyclohexapeptides
WO2009158034A1 (en) *	2008-06-25	2009-12-30	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Caspofungin free of caspofungin impurity a
WO2010064219A1 (en)	2008-12-04	2010-06-10	Ranbaxy Laboratories Limited	Process for the preparation of a novel intermediate for caspofungin
US20120190815A1 (en) *	2009-08-06	2012-07-26	Tianhui Xu	Azacyclohexapeptide or its pharmaceutical acceptable salt, preparing method and use thereof
CN101792486A (zh) *	2010-04-12	2010-08-04	浙江海正药业股份有限公司	一种合成醋酸卡泊芬净的方法
CN102219832B (zh)	2010-04-15	2013-08-21	上海天伟生物制药有限公司	一种氮杂环六肽或其盐的纯化方法
WO2012041801A1 (en)	2010-09-28	2012-04-05	Dsm Sinochem Pharmaceuticals Netherlands B.V.	Method for isolating a cyclohexapeptide
EP2623511B1 (en) *	2010-09-29	2016-04-06	Shanghai Techwell Biopharmaceutical Co., Ltd	Process for purifying cyclic lipopeptide compounds or salts thereof
CN102367267B (zh)	2010-11-10	2013-09-04	上海天伟生物制药有限公司	一种卡泊芬净的制备方法
CN102367268B (zh) *	2010-11-10	2013-11-06	上海天伟生物制药有限公司	一种卡泊芬净类似物及其用途
CN102367269B (zh) *	2010-11-10	2013-11-06	上海天伟生物制药有限公司	一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko)	2010-12-09	2013-11-25	종근당바이오 주식회사	카스포펀진 제조방법 및 그의 신규 중간체
CN102219833A (zh) *	2011-04-18	2011-10-19	深圳市健元医药科技有限公司	一种更加安全的棘白菌类抗真菌药的制备方法
CN102746384B (zh) *	2011-04-22	2016-01-20	上海天伟生物制药有限公司	一种高纯度的卡泊芬净或其盐及其制备方法和用途
CA2833206A1 (en)	2011-04-28	2012-11-01	Unitris Biopharma Co., Ltd.	Intermediate for synthesizing caspofungin and preparation method therefor
CN103483426A (zh) *	2012-06-14	2014-01-01	博瑞生物医药技术(苏州)有限公司	一种氮杂环己肽的制备方法
LT2922530T (lt)	2012-11-20	2017-01-25	Fresenius Kabi Usa, Llc	Kaspofungino acetato kompozicijos
EP3620462A1 (en)	2018-09-04	2020-03-11	Xellia Pharmaceuticals ApS	Process for the preparation of caspofungin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2704030A1 (de) *	1976-02-12	1977-08-18	Sandoz Ag	Neue organische verbindungen, ihre herstellung und verwendung
IE910892A1 (en) *	1990-03-19	1991-09-25	Merck & Co Inc	Lipopeptide compounds
US5939384A (en) *	1991-10-01	1999-08-17	Merck & Co., Inc.	Cyclohexapeptidyl propanolamine compounds
US5378804A (en) *	1993-03-16	1995-01-03	Merck & Co., Inc.	Aza cyclohexapeptide compounds
US6268338B1 (en) *	1993-04-30	2001-07-31	Merck & Co., Inc.	Cyclohexapeptidyl amine compounds
AU692043B2 (en) *	1994-08-23	1998-05-28	Merck & Co., Inc.	An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
AU692308B2 (en) *	1994-09-16	1998-06-04	Merck Sharp & Dohme Corp.	Aza cyclohexapeptide compounds

1995
- 1995-02-10 US US08/386,618 patent/US5552521A/en not_active Expired - Lifetime
1996
- 1996-02-01 TW TW085101244A patent/TW515805B/zh not_active IP Right Cessation
- 1996-02-05 HR HR960054A patent/HRP960054B1/xx not_active IP Right Cessation
- 1996-02-06 EP EP96905366A patent/EP0808330B1/en not_active Expired - Lifetime
- 1996-02-06 ES ES96905366T patent/ES2249778T3/es not_active Expired - Lifetime
- 1996-02-06 DE DE69635405T patent/DE69635405T2/de not_active Expired - Lifetime
- 1996-02-06 AT AT96905366T patent/ATE309266T1/de active
- 1996-02-06 HU HU9901085A patent/HU229780B1/hu unknown
- 1996-02-06 WO PCT/US1996/001523 patent/WO1996024613A1/en active IP Right Grant
- 1996-02-06 CN CN96191834A patent/CN1127515C/zh not_active Expired - Lifetime
- 1996-02-06 EA EA199700170A patent/EA000564B1/ru not_active IP Right Cessation
- 1996-02-06 BR BR9607721A patent/BR9607721A/pt not_active Application Discontinuation
- 1996-02-06 CZ CZ19972525A patent/CZ286683B6/cs not_active IP Right Cessation
- 1996-02-06 NZ NZ302967A patent/NZ302967A/en not_active IP Right Cessation
- 1996-02-06 AU AU49147/96A patent/AU692071B2/en not_active Expired
- 1996-02-06 SK SK1079-97A patent/SK283115B6/sk not_active IP Right Cessation
- 1996-02-06 CA CA002211314A patent/CA2211314C/en not_active Expired - Lifetime
- 1996-02-07 AR AR33533596A patent/AR001081A1/es unknown
- 1996-02-09 YU YU8496A patent/YU49459B/sh unknown
1997
- 1997-01-14 AR ARP970100139A patent/AR005462A1/es not_active Application Discontinuation
- 1997-08-08 FI FI973281A patent/FI120693B/fi not_active IP Right Cessation
1998
- 1998-05-06 HK HK98103878A patent/HK1004676A1/xx not_active IP Right Cessation
1999
- 1999-12-17 CZ CZ19994601A patent/CZ286767B6/cs not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ302967A (en)	1998-11-25
ATE309266T1 (de)	2005-11-15
HUP9901085A2 (hu)	1999-09-28
AU692071B2 (en)	1998-05-28
CZ286767B6 (cs)	2000-06-14
HK1004676A1 (en)	1998-12-04
DE69635405D1 (de)	2005-12-15
AR001081A1 (es)	1997-09-24
FI120693B (fi)	2010-01-29
EA199700170A1 (ru)	1997-12-30
US5552521A (en)	1996-09-03
SK107997A3 (en)	1998-02-04
HU229780B1 (en)	2014-07-28
CN1173875A (zh)	1998-02-18
CN1127515C (zh)	2003-11-12
AU4914796A (en)	1996-08-27
AR005462A1 (es)	1999-06-23
CA2211314C (en)	2007-04-17
SK283115B6 (sk)	2003-02-04
BR9607721A (pt)	1998-07-14
HUP9901085A3 (en)	2000-11-28
CA2211314A1 (en)	1996-08-15
FI973281A (fi)	1997-08-08
YU49459B (sh)	2006-03-03
HRP960054B1 (en)	2008-07-31
TW515805B (en)	2003-01-01
EP0808330A1 (en)	1997-11-26
EA000564B1 (ru)	1999-12-29
FI973281A0 (fi)	1997-08-08
ES2249778T3 (es)	2006-04-01
DE69635405T2 (de)	2006-07-27
MX9706101A (es)	1997-10-31
CZ286683B6 (en)	2000-06-14
HRP960054A2 (en)	1997-10-31
WO1996024613A1 (en)	1996-08-15
YU8496A (sh)	1999-06-15
EP0808330B1 (en)	2005-11-09

Publication	Publication Date	Title
CZ252597A3 (cs)	1998-01-14	Způsob výroby azacyklohexapeptidů
HUP9902419A3 (en)	2002-12-28	Process for preparing nitrobiphenylene
HUP9900318A3 (en)	2001-09-28	Process for preparing 4-aryl-piperidine derivatives
IL119402A0 (en)	1997-01-10	Process for preparing nicotinamide
ZA96982B (en)	1996-08-19	Process for preparing an organoaluminoxy product
EG24221A (en)	2008-11-10	Process for preparing olanzapine
SG81901A1 (en)	2001-07-24	Process for preparing thiols
ZA961555B (en)	1996-08-19	Process for preparing doxorubicin
IL118992A (en)	2000-06-01	Process for preparing norbenzomorphan derivatives
HUP9602960A2 (en)	1997-10-28	Process for producing alkylcarbazates
GB2317178B (en)	2000-07-05	Process for preparing 1-chloromethylsilatrane
NZ321968A (en)	1999-05-28	Process for preparing dioxoazabicyclohexanes
EP0742221A3 (en)	1997-05-14	Process for the production of trimethyl aluminum
GR3033873T3 (en)	2000-10-31	Method for preparing streptogramines
HUP9602988A3 (en)	1998-01-28	Process for producing 2-chloracrylnitril
GR3030254T3 (en)	1999-08-31	Process for preparing substituted aminotriazolinones
EP0751112A3 (de)	1997-09-10	Verfahren zur Herstellung von Arylidensubstituierten Alkylcycloalkanonen
GB9613005D0 (en)	1996-08-21	Process for preparing 4-tert-butyloxycarbonyl-(s)-piperazine-2-tert-butylcarboxamide
EP0751111A3 (de)	1997-09-10	Verfahren zur Herstellung von 2,2-Dialkylaryliden-cycloalkanonen
HU9600350D0 (en)	1996-04-29	Process for preparing diltiazem
HUP9801592A3 (en)	2001-05-28	Process for preparing substituted aryluracils
HUT76300A (en)	1997-07-28	Process for producing veratrumaldehyde
IL113834A0 (en)	1995-08-31	Process for preparing p-alkoxybenzaldehydes
GB2303368B (en)	1998-02-18	Process for preparing trichlorobutyl acetate
LT95056A (en)	1996-12-27	Process for preparing cake

Legal Events

Date	Code	Title	Description
2000-06-30	IF00	In force as of 2000-06-30 in czech republic
2016-02-17	MK4A	Patent expired	Effective date: 20160206