HRP20130327T1 - Novi derivati dihidroindolona, postupak za njihovu pripravu i farmaceutski spojevi koji ih sadržavaju - Google Patents

Novi derivati dihidroindolona, postupak za njihovu pripravu i farmaceutski spojevi koji ih sadržavaju

Info

Publication number: HRP20130327T1
Authority: HR; Croatia
Prior art keywords: alkyl; new; optionally substituted; heterocyclic group; derivatives
Prior art date: 2009-08-04

Application number

HRP20130327AT

Other languages

English (en)

Inventor

Jean-Claude Ortuno

Alexis Cordi

Pok. Lacoste

Imre Fejes

Michael Burbridge

John Hickman

Alain Pierre

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-08-04

Filing date

2013-04-10

Publication date

2013-05-31

2013-04-10 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2013-05-31 Publication of HRP20130327T1 publication Critical patent/HRP20130327T1/hr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Storage Device Security (AREA)
Computer And Data Communications (AREA)

HRP20130327AT 2009-08-04 2013-04-10 Novi derivati dihidroindolona, postupak za njihovu pripravu i farmaceutski spojevi koji ih sadržavaju HRP20130327T1 (hr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0903839A FR2948940B1 (fr)	2009-08-04	2009-08-04	Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
HRP20130327T1 true HRP20130327T1 (hr)	2013-05-31

Family

ID=41796204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP20130327AT HRP20130327T1 (hr)	2009-08-04	2013-04-10	Novi derivati dihidroindolona, postupak za njihovu pripravu i farmaceutski spojevi koji ih sadržavaju

Country Status (43)

Country	Link
US (3)	US8133889B2 (hr)
EP (1)	EP2281822B1 (hr)
JP (2)	JP5475588B2 (hr)
KR (1)	KR101309101B1 (hr)
CN (1)	CN101987848B (hr)
AP (1)	AP2756A (hr)
AR (1)	AR077510A1 (hr)
AU (1)	AU2010203305B2 (hr)
BR (1)	BRPI1003241A2 (hr)
CA (1)	CA2710224C (hr)
CL (1)	CL2010000804A1 (hr)
CO (1)	CO6320143A1 (hr)
CU (1)	CU23921B1 (hr)
CY (1)	CY1113914T1 (hr)
DK (1)	DK2281822T3 (hr)
EA (1)	EA019481B1 (hr)
EC (1)	ECSP10010380A (hr)
ES (1)	ES2403227T3 (hr)
FR (1)	FR2948940B1 (hr)
GE (1)	GEP20125548B (hr)
HK (1)	HK1155742A1 (hr)
HN (1)	HN2010001537A (hr)
HR (1)	HRP20130327T1 (hr)
IL (1)	IL207183A (hr)
JO (1)	JO2808B1 (hr)
MA (1)	MA32184B1 (hr)
ME (1)	ME01491B (hr)
MX (1)	MX2010008557A (hr)
MY (1)	MY183326A (hr)
NI (1)	NI201000134A (hr)
NZ (1)	NZ586993A (hr)
PE (1)	PE20110206A1 (hr)
PL (1)	PL2281822T3 (hr)
PT (1)	PT2281822E (hr)
RS (1)	RS52701B (hr)
SA (1)	SA110310634B1 (hr)
SG (1)	SG168499A1 (hr)
SI (1)	SI2281822T1 (hr)
TW (1)	TWI408138B (hr)
UA (1)	UA105357C2 (hr)
UY (1)	UY32801A (hr)
WO (1)	WO2011015728A1 (hr)
ZA (1)	ZA201005424B (hr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2948940B1 (fr)	2009-08-04	2011-07-22	Servier Lab	Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US10245270B2 (en) *	2013-07-12	2019-04-02	Les Laboratoires Servier	Salt of 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, its preparation, and formulations containing it
FR3008411B1 (fr) *	2013-07-12	2015-07-03	Servier Lab	Nouveau sel de la 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, sa preparation, et les formulations qui le contiennent
JP6156845B2 (ja) *	2014-03-04	2017-07-05	株式会社島津製作所	マトリックス支援レーザ脱離イオン化質量分析用マトリックス
FR3039401B1 (fr) *	2015-07-31	2018-07-13	Les Laboratoires Servier	Nouvelle association entre le 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione et un inhibiteur de la tyr kinase du egfr
US10343991B2 (en) *	2016-11-02	2019-07-09	Council Of Scientific & Industrial Research	C5, C6 substituted and/or fused oxindoles as anti-cancer agents and process for preparation thereof
JOP20200024A1 (ar)	2017-08-04	2020-02-02	Bayer Ag	مركبات ثنائي هيدروكساديازينون
CA3071795A1 (en)	2017-08-04	2019-02-07	Bayer Aktiengesellschaft	6-phenyl-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
CN113845524B (zh) *	2021-10-29	2023-11-07	四川农业大学	一种螺吡咯吲哚酮类化合物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0892248A (ja) *	1994-09-26	1996-04-09	Yamanouchi Pharmaceut Co Ltd	インドリノン誘導体
AU5468499A (en) *	1998-08-04	2000-02-28	Sugen, Inc.	3-methylidenyl-2-indolinone modulators of protein kinase
AU770375B2 (en) *	1998-12-17	2004-02-19	F. Hoffmann-La Roche Ag	4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular CDK2
CA2377513A1 (en)	1999-06-25	2001-01-04	Universitat Zurich	Hetero-associating coiled-coil peptides
AU2001239770B2 (en) *	2000-02-15	2006-01-05	Pharmacia & Upjohn Company	Pyrrole substituted 2-indolinone protein kinase inhibitors
AR042586A1 (es) *	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
JP4363985B2 (ja) *	2001-12-27	2009-11-11	セラヴァンス，インコーポレーテッド	タンパク質キナーゼ阻害剤として有用なインドリン誘導体
US7012088B2 (en) *	2003-02-24	2006-03-14	Pharmacia & Upjohn Company	Indolone oxazolidinones and derivatives thereof
AU2004284084A1 (en) *	2003-10-24	2005-05-06	Schering Aktiengesellschaft	Indolinone derivatives and their use in treating disease-states such as cancer
US7378530B2 (en)	2005-02-22	2008-05-27	Nereus Pharmaceuticals, Inc.	Anti-cancer and anti-microbial 5-membered heterocyclic compounds
CA2635360A1 (en) *	2005-12-29	2007-07-19	The Scripps Research Institute	Amino acid derivatives of indolinone based protein kinase inhibitors
FR2948940B1 (fr)	2009-08-04	2011-07-22	Servier Lab	Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

2009
- 2009-08-04 FR FR0903839A patent/FR2948940B1/fr not_active Expired - Fee Related
2010
- 2010-07-21 PE PE2010000465A patent/PE20110206A1/es active IP Right Grant
- 2010-07-22 UY UY0001032801A patent/UY32801A/es not_active Application Discontinuation
- 2010-07-23 NZ NZ586993A patent/NZ586993A/en not_active IP Right Cessation
- 2010-07-23 SG SG201005343-7A patent/SG168499A1/en unknown
- 2010-07-23 MY MYPI2010003506A patent/MY183326A/en unknown
- 2010-07-23 AU AU2010203305A patent/AU2010203305B2/en not_active Ceased
- 2010-07-23 CO CO10090014A patent/CO6320143A1/es not_active Application Discontinuation
- 2010-07-25 IL IL207183A patent/IL207183A/en not_active IP Right Cessation
- 2010-07-25 JO JO2010262A patent/JO2808B1/en active
- 2010-07-26 AP AP2010005343A patent/AP2756A/xx active
- 2010-07-28 CL CL2010000804A patent/CL2010000804A1/es unknown
- 2010-07-28 CA CA2710224A patent/CA2710224C/fr not_active Expired - Fee Related
- 2010-07-29 ZA ZA2010/05424A patent/ZA201005424B/en unknown
- 2010-07-30 GE GEAP201011902A patent/GEP20125548B/en unknown
- 2010-07-30 AR ARP100102775A patent/AR077510A1/es active IP Right Grant
- 2010-08-02 CU CU2010000157A patent/CU23921B1/es active IP Right Grant
- 2010-08-02 MA MA33053A patent/MA32184B1/fr unknown
- 2010-08-02 UA UAA201009661A patent/UA105357C2/uk unknown
- 2010-08-03 ES ES10290436T patent/ES2403227T3/es active Active
- 2010-08-03 CN CN201010246097.6A patent/CN101987848B/zh not_active Expired - Fee Related
- 2010-08-03 TW TW099125790A patent/TWI408138B/zh not_active IP Right Cessation
- 2010-08-03 EC EC2010010380A patent/ECSP10010380A/es unknown
- 2010-08-03 KR KR1020100074879A patent/KR101309101B1/ko active IP Right Grant
- 2010-08-03 EP EP10290436A patent/EP2281822B1/fr active Active
- 2010-08-03 WO PCT/FR2010/000560 patent/WO2011015728A1/fr active Application Filing
- 2010-08-03 BR BRPI1003241-0A patent/BRPI1003241A2/pt not_active Application Discontinuation
- 2010-08-03 JP JP2010174734A patent/JP5475588B2/ja not_active Expired - Fee Related
- 2010-08-03 EA EA201001087A patent/EA019481B1/ru not_active IP Right Cessation
- 2010-08-03 ME MEP-2013-33A patent/ME01491B/me unknown
- 2010-08-03 DK DK10290436.4T patent/DK2281822T3/da active
- 2010-08-03 HN HN2010001537A patent/HN2010001537A/es unknown
- 2010-08-03 NI NI201000134A patent/NI201000134A/es unknown
- 2010-08-03 RS RS20130099A patent/RS52701B/en unknown
- 2010-08-03 SI SI201030147T patent/SI2281822T1/sl unknown
- 2010-08-03 PT PT102904364T patent/PT2281822E/pt unknown
- 2010-08-03 PL PL10290436T patent/PL2281822T3/pl unknown
- 2010-08-03 SA SA110310634A patent/SA110310634B1/ar unknown
- 2010-08-04 US US12/806,045 patent/US8133889B2/en not_active Expired - Fee Related
- 2010-08-04 MX MX2010008557A patent/MX2010008557A/es active IP Right Grant
2011
- 2011-09-22 HK HK11110000.4A patent/HK1155742A1/xx not_active IP Right Cessation
- 2011-11-02 US US13/373,016 patent/US8541412B2/en not_active Expired - Fee Related
2013
- 2013-02-13 JP JP2013025505A patent/JP5538580B2/ja not_active Expired - Fee Related
- 2013-02-21 US US13/772,984 patent/US8653073B2/en not_active Expired - Fee Related
- 2013-04-04 CY CY20131100282T patent/CY1113914T1/el unknown
- 2013-04-10 HR HRP20130327AT patent/HRP20130327T1/hr unknown

Also Published As

Publication number	Publication date
ES2403227T3 (es)	2013-05-16
AR077510A1 (es)	2011-08-31
UY32801A (es)	2011-01-31
JP2011037848A (ja)	2011-02-24
US8653073B2 (en)	2014-02-18
CL2010000804A1 (es)	2011-08-26
US8133889B2 (en)	2012-03-13
US20130331380A1 (en)	2013-12-12
ECSP10010380A (es)	2011-03-31
GEP20125548B (en)	2012-05-25
JP5538580B2 (ja)	2014-07-02
NZ586993A (en)	2012-01-12
TW201118092A (en)	2011-06-01
AP2010005343A0 (en)	2010-08-31
CN101987848A (zh)	2011-03-23
KR20110014116A (ko)	2011-02-10
IL207183A (en)	2014-01-30
EP2281822B1 (fr)	2013-01-16
EA019481B1 (ru)	2014-04-30
SA110310634B1 (ar)	2013-11-10
JP2013116908A (ja)	2013-06-13
MY183326A (en)	2021-02-18
ME01491B (me)	2014-04-20
SI2281822T1 (sl)	2013-04-30
CA2710224A1 (fr)	2011-02-04
CN101987848B (zh)	2014-06-18
US20120046287A1 (en)	2012-02-23
UA105357C2 (uk)	2014-05-12
HK1155742A1 (en)	2012-05-25
HN2010001537A (es)	2013-05-06
MA32184B1 (fr)	2011-04-01
DK2281822T3 (da)	2013-04-22
IL207183A0 (en)	2010-12-30
US8541412B2 (en)	2013-09-24
US20110034460A1 (en)	2011-02-10
KR101309101B1 (ko)	2013-09-16
PE20110206A1 (es)	2011-04-09
TWI408138B (zh)	2013-09-11
EP2281822A1 (fr)	2011-02-09
ZA201005424B (en)	2011-04-28
EA201001087A1 (ru)	2011-04-29
JP5475588B2 (ja)	2014-04-16
CU23921B1 (es)	2013-07-31
PT2281822E (pt)	2013-02-27
PL2281822T3 (pl)	2013-06-28
AU2010203305A1 (en)	2011-02-24
FR2948940B1 (fr)	2011-07-22
JO2808B1 (en)	2014-09-15
BRPI1003241A2 (pt)	2012-04-10
SG168499A1 (en)	2011-02-28
CO6320143A1 (es)	2011-09-20
FR2948940A1 (fr)	2011-02-11
WO2011015728A1 (fr)	2011-02-10
CU20100157A7 (es)	2012-03-15
MX2010008557A (es)	2011-02-03
AP2756A (en)	2013-09-30
AU2010203305B2 (en)	2015-02-05
CA2710224C (fr)	2013-01-08
CY1113914T1 (el)	2016-07-27
NI201000134A (es)	2014-02-11
RS52701B (en)	2013-08-30

Publication	Publication Date	Title
HRP20130327T1 (hr)	2013-05-31	Novi derivati dihidroindolona, postupak za njihovu pripravu i farmaceutski spojevi koji ih sadržavaju
GEP20146146B (en)	2014-08-25	Pyrrolopyrimidine compounds as inhibitors of cdk4/6
CO6470846A2 (es)	2012-06-29	Derivados aminobut´ricos sustituidos como inhibidores de neprilisina
UY31069A1 (es)	2009-01-05	Nuevos derivados de imidazoquinola, composiciones conteniendolos, proceso de preparacion y aplicaciones
AR079205A1 (es)	2012-01-04	Morfolinotiazoles como moduladores alostericos positivos alfa 7
DOP2010000310A (es)	2011-03-15	2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas
BR112013011580A2 (pt)	2016-08-09	derivados de ácido bisfenil pentanoico substituído por amino como inibidores de nep
MY161094A (en)	2017-04-14	Anti-tumor effect potentiator
NO20091858L (no)	2009-07-08	Hydrobenzamid derivater som inhibitorer av HSP90
MX2012003982A (es)	2012-05-08	Pirrolidinas n-substituidas.
EA200801828A2 (ru)	2009-04-28	Соединения 1,2,4,5-тетрагидро-3h-бензазепина, способ их получения и фармацевтические композиции, содержащие эти соединения
BR112014007405A2 (pt)	2017-04-04	composto; forma farmacêutica; e hexasulfato de inositol
EA201070588A1 (ru)	2010-10-29	Производные 1,2,3-триазола для применения в качестве ингибиторов стеароил-соа десатуразы
AU2011327113A8 (en)	2015-07-16	Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
AR061185A1 (es)	2008-08-13	Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
AR082865A1 (es)	2013-01-16	Derivados de triazolo[4,3-a]piridina, y sus usos
UY32635A (es)	2010-12-31	Derivados de bis-(sulfonilamino) en terapia 735
CO6331433A2 (es)	2011-10-20	2,6-diamino-pirimidin-5-ilcarboxamidas como inhibidores de syk p jak quinasas
MX2010013938A (es)	2011-09-27	Derivados triciclicos sustituidos contra las enfermedades neurodegenerativas.
AR078817A1 (es)	2011-12-07	Derivados de aminopiridina inhibidores selectivos de calicreina tisular humana klk1, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades respiratorias y alergicas.
AR077429A1 (es)	2011-08-24	Compuestos hidroxiasenapina sus derivados y composiciones farmaceuticas que comprenden los mismos
ATE452636T1 (de)	2010-01-15	3-azabicycloä4.1.0üheptan-derivate zur behandlung von depressionen
AR078819A1 (es)	2011-12-07	Derivados de aminotiazol inhibidores de calicreina tisular humana klk1), composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias respiratorias, tales como asma, entre otras.
CY1114729T1 (el)	2016-10-05	Παραγωγα διϋδρο-οξαζολοβενζοδιαζεπινονης, μεθοδοι για την παρασκευη αυτων και φαρμακευτικες συνθεσεις που περιεχουν αυτες τις ενωσεις
UY32412A (es)	2010-09-30	DERIVADOS DE 4-AMINO-7,8-DIHIDROPIRIMIDO [4,3-d] PIRIMIDIN-5 (6H)-ONA