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HRP20120137T1 - Pojačivači glutamatnih receptora - Google Patents

Pojačivači glutamatnih receptora Download PDF

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Publication number
HRP20120137T1
HRP20120137T1 HR20120137T HRP20120137T HRP20120137T1 HR P20120137 T1 HRP20120137 T1 HR P20120137T1 HR 20120137 T HR20120137 T HR 20120137T HR P20120137 T HRP20120137 T HR P20120137T HR P20120137 T1 HRP20120137 T1 HR P20120137T1
Authority
HR
Croatia
Prior art keywords
compound
phenyl
formula
image
compound according
Prior art date
Application number
HR20120137T
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English (en)
Croatian (hr)
Inventor
Daniel Aicher Thomas
S. Cortez Guillermo
Michael Groendyke Todd
Khilevich Albert
Allen Knobelsdorf James
Andrew Magnus Nicholas
Pehr Marmsater Fredrik
Michael Schkeryantz Jeffrey
Pisal Tang Tony
Original Assignee
Eli Lilly And Company
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Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of HRP20120137T1 publication Critical patent/HRP20120137T1/hr

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    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/63—One oxygen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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HR20120137T 2004-11-22 2012-02-10 Pojačivači glutamatnih receptora HRP20120137T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63006004P 2004-11-22 2004-11-22
PCT/US2005/041441 WO2006057870A1 (en) 2004-11-22 2005-11-15 Potentiators of glutamate receptors

Publications (1)

Publication Number Publication Date
HRP20120137T1 true HRP20120137T1 (hr) 2012-03-31

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RS52268B (en) 2012-10-31
EP1817296A1 (en) 2007-08-15
EA200701121A1 (ru) 2007-12-28
PT1817300E (pt) 2010-05-28
CN101061106A (zh) 2007-10-24
TNSN07195A1 (en) 2008-11-21
CN101955470A (zh) 2011-01-26
BRPI0518360A2 (pt) 2008-11-18
US20080004321A1 (en) 2008-01-03
ZA200703579B (en) 2009-04-29
SI1817301T1 (sl) 2012-04-30
JP5175551B2 (ja) 2013-04-03
IL182957A (en) 2012-08-30
NZ554399A (en) 2010-10-29
ZA200704001B (en) 2008-10-29
US7858646B2 (en) 2010-12-28
EP1817301A1 (en) 2007-08-15
ES2340600T3 (es) 2010-06-07
CN101061105A (zh) 2007-10-24
EP1817296B1 (en) 2009-11-04
EA200701122A1 (ru) 2007-12-28
EP1817301B1 (en) 2012-02-01
ATE543807T1 (de) 2012-02-15
DE602005017510D1 (de) 2009-12-17
JP2008520680A (ja) 2008-06-19
IL182959A0 (en) 2007-08-19
CA2588881A1 (en) 2006-06-01
AU2005309865B2 (en) 2011-07-28
PT1817301E (pt) 2012-04-03
DE602005020056D1 (de) 2010-04-29
ES2333979T3 (es) 2010-03-03
WO2006057870A1 (en) 2006-06-01
US20090318483A1 (en) 2009-12-24
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