HRP20100260T1 - Postupak za proizvodnju stroncij ranelata i njegovih hidrata - Google Patents

Postupak za proizvodnju stroncij ranelata i njegovih hidrata Download PDF

Info

Publication number: HRP20100260T1
Authority: HR; Croatia
Prior art keywords: formula; process according; synthesis process; iii; reaction
Prior art date: 2007-09-26

Application number

HR20100260T

Other languages

English (en)

Croatian (hr)

Inventor

Vaysse-Ludot Lucile

Lecouve Jean-Pierre

Langlois Pascal

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-26

Filing date

2010-05-11

Publication date

2010-06-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39431194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20100260(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-05-11 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2010-06-30 Publication of HRP20100260T1 publication Critical patent/HRP20100260T1/hr

Links

ZHEZAQJNZMLYBA-UHFFFAOYSA-J distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate;octahydrate Chemical compound O.O.O.O.O.O.O.O.[Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N ZHEZAQJNZMLYBA-UHFFFAOYSA-J 0.000 title claims abstract 6
229940079488 strontium ranelate Drugs 0.000 title claims abstract 6
150000004677 hydrates Chemical class 0.000 title claims abstract 5
238000004519 manufacturing process Methods 0.000 title 1
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims abstract 12
230000015572 biosynthetic process Effects 0.000 claims abstract 11
238000000034 method Methods 0.000 claims abstract 11
238000003786 synthesis reaction Methods 0.000 claims abstract 11
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims abstract 9
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract 9
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract 8
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract 8
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract 8
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims abstract 8
ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims abstract 8
229910001631 strontium chloride Inorganic materials 0.000 claims abstract 8
AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims abstract 8
150000001875 compounds Chemical class 0.000 claims abstract 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract 6
150000003839 salts Chemical class 0.000 claims abstract 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 4
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims abstract 4
239000000203 mixture Substances 0.000 claims abstract 4
239000003960 organic solvent Substances 0.000 claims abstract 4
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims abstract 4
JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 2
238000002955 isolation Methods 0.000 claims abstract 2
229910052700 potassium Inorganic materials 0.000 claims abstract 2
229910052708 sodium Inorganic materials 0.000 claims abstract 2
239000011734 sodium Substances 0.000 claims abstract 2
238000006243 chemical reaction Methods 0.000 claims 6
238000001914 filtration Methods 0.000 claims 2
239000012266 salt solution Substances 0.000 claims 2
238000001035 drying Methods 0.000 claims 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
238000007127 saponification reaction Methods 0.000 claims 1
238000001308 synthesis method Methods 0.000 claims 1
238000005406 washing Methods 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Physical Education & Sports Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Catalysts (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Inorganic Compounds Of Heavy Metals (AREA)

HR20100260T 2007-09-26 2010-05-11 Postupak za proizvodnju stroncij ranelata i njegovih hidrata HRP20100260T1 (hr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0706731A FR2921367B1 (fr)	2007-09-26	2007-09-26	Nouveau procede de synthese du ranelate de strontium et de ses hydrates

Publications (1)

Publication Number	Publication Date
HRP20100260T1 true HRP20100260T1 (hr)	2010-06-30

Family

ID=39431194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20100260T HRP20100260T1 (hr)	2007-09-26	2010-05-11	Postupak za proizvodnju stroncij ranelata i njegovih hidrata

Country Status (47)

Country	Link
US (2)	US8063100B2 (sl)
EP (1)	EP2042497B1 (sl)
JP (1)	JP5016575B2 (sl)
KR (1)	KR101099995B1 (sl)
CN (1)	CN101397292A (sl)
AP (1)	AP2400A (sl)
AR (1)	AR068535A1 (sl)
AT (1)	ATE460408T1 (sl)
AU (1)	AU2008221618B2 (sl)
BR (1)	BRPI0803636A2 (sl)
CA (1)	CA2640041C (sl)
CL (1)	CL2008002833A1 (sl)
CO (1)	CO6110143A1 (sl)
CR (1)	CR10292A (sl)
CY (1)	CY1110036T1 (sl)
DE (1)	DE602008000790D1 (sl)
DK (1)	DK2042497T3 (sl)
EA (1)	EA014247B1 (sl)
EC (1)	ECSP088771A (sl)
ES (1)	ES2342233T3 (sl)
FR (1)	FR2921367B1 (sl)
GE (1)	GEP20115191B (sl)
GT (1)	GT200800190A (sl)
HN (1)	HN2008001490A (sl)
HR (1)	HRP20100260T1 (sl)
IL (1)	IL194089A (sl)
JO (1)	JO2964B1 (sl)
MA (1)	MA30319B1 (sl)
ME (1)	ME01849B (sl)
MX (1)	MX2008012119A (sl)
MY (1)	MY144180A (sl)
NI (1)	NI200800257A (sl)
NZ (1)	NZ571511A (sl)
PA (1)	PA8797001A1 (sl)
PE (1)	PE20090703A1 (sl)
PL (1)	PL2042497T3 (sl)
PT (1)	PT2042497E (sl)
RS (1)	RS51356B (sl)
SA (1)	SA08290594B1 (sl)
SG (1)	SG151207A1 (sl)
SI (1)	SI2042497T1 (sl)
SV (1)	SV2008003033A (sl)
TW (1)	TWI358408B (sl)
UA (1)	UA97638C2 (sl)
UY (1)	UY31341A1 (sl)
WO (1)	WO2009074741A2 (sl)
ZA (1)	ZA200808176B (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2921367B1 (fr) *	2007-09-26	2009-10-30	Servier Lab	Nouveau procede de synthese du ranelate de strontium et de ses hydrates
EP2346846A1 (en) *	2008-09-29	2011-07-27	Ratiopharm GmbH	Anhydrate and hydrate forms of strontium ranelate
HU228820B1 (en)	2010-01-14	2013-05-28	Richter Gedeon Nyrt	Process for the preparation of distrontium ranelate
IT1398542B1 (it) *	2010-03-05	2013-03-01	Chemelectiva S R L	Processo per la preparazione di un polimorfo
WO2011110597A1 (de)	2010-03-11	2011-09-15	Azad Pharmaceutical Ingredients Ag	Verfahren zur herstellung von strontiumranelat
WO2011124992A1 (en) *	2010-03-24	2011-10-13	Actavis Group Ptc Ehf	Substantially pure strontium ranelate
US20110275834A1 (en) *	2010-05-06	2011-11-10	Divi's Laboratories, Limited	Polymorph of strontium ranelate and a process for its preparation
WO2012046251A2 (en) *	2010-10-08	2012-04-12	Glenmark Generics Limited	Novel form of ranelic acid
CZ2011320A3 (cs) *	2011-05-30	2012-12-12	Zentiva, K.S.	Stabilní krystalická forma X stroncium ranelátu
CN102391247B (zh) *	2011-09-20	2016-12-28	浙江华海药业股份有限公司	一种雷尼酸锶水合物晶形k及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
GB2235691A (en) *	1989-09-04	1991-03-13	Du Pont Canada	Concentrates of modifying agents in polymers
JP3880262B2 (ja) *	1998-11-02	2007-02-14	株式会社カネカ	水不溶化再生コラーゲン繊維の製造方法
FR2844797B1 (fr)	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
US7138529B2 (en) *	2003-04-16	2006-11-21	Hoffmann-La Roche Inc.	Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists
AU2006281157B2 (en) *	2005-08-19	2013-03-28	Glenmark Pharmaceuticals Limited	Process for the preparation of strontium ranelate
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
CN100554263C (zh) *	2006-07-19	2009-10-28	天津药物研究院	雷奈酸锶七水合物的制备方法
FR2921367B1 (fr) *	2007-09-26	2009-10-30	Servier Lab	Nouveau procede de synthese du ranelate de strontium et de ses hydrates

2007
- 2007-09-26 FR FR0706731A patent/FR2921367B1/fr not_active Expired - Fee Related
2008
- 2008-09-15 UY UY31341A patent/UY31341A1/es unknown
- 2008-09-15 AP AP2008004617A patent/AP2400A/xx active
- 2008-09-15 SG SG200806787-8A patent/SG151207A1/en unknown
- 2008-09-15 PE PE2008001612A patent/PE20090703A1/es not_active Application Discontinuation
- 2008-09-15 IL IL194089A patent/IL194089A/en not_active IP Right Cessation
- 2008-09-16 MA MA31243A patent/MA30319B1/fr unknown
- 2008-09-16 MY MYPI20083603A patent/MY144180A/en unknown
- 2008-09-17 CR CR10292A patent/CR10292A/es unknown
- 2008-09-17 CN CNA2008101489170A patent/CN101397292A/zh active Pending
- 2008-09-19 CO CO08099515A patent/CO6110143A1/es active IP Right Grant
- 2008-09-19 UA UAA200811373A patent/UA97638C2/ru unknown
- 2008-09-19 SV SV2008003033A patent/SV2008003033A/es active IP Right Grant
- 2008-09-19 AU AU2008221618A patent/AU2008221618B2/en not_active Ceased
- 2008-09-19 GT GT200800190A patent/GT200800190A/es unknown
- 2008-09-20 SA SA08290594A patent/SA08290594B1/ar unknown
- 2008-09-22 GE GEAP200810919A patent/GEP20115191B/en unknown
- 2008-09-23 MX MX2008012119A patent/MX2008012119A/es active IP Right Grant
- 2008-09-24 PA PA20088797001A patent/PA8797001A1/es unknown
- 2008-09-24 AR ARP080104129A patent/AR068535A1/es not_active Application Discontinuation
- 2008-09-24 TW TW097136693A patent/TWI358408B/zh not_active IP Right Cessation
- 2008-09-24 US US12/284,695 patent/US8063100B2/en not_active Expired - Fee Related
- 2008-09-24 CL CL2008002833A patent/CL2008002833A1/es unknown
- 2008-09-25 EP EP08290906A patent/EP2042497B1/fr active Active
- 2008-09-25 NZ NZ571511A patent/NZ571511A/en not_active IP Right Cessation
- 2008-09-25 AT AT08290906T patent/ATE460408T1/de active
- 2008-09-25 SI SI200830031T patent/SI2042497T1/sl unknown
- 2008-09-25 WO PCT/FR2008/001329 patent/WO2009074741A2/fr active Application Filing
- 2008-09-25 PL PL08290906T patent/PL2042497T3/pl unknown
- 2008-09-25 KR KR1020080094125A patent/KR101099995B1/ko not_active IP Right Cessation
- 2008-09-25 DK DK08290906.0T patent/DK2042497T3/da active
- 2008-09-25 DE DE602008000790T patent/DE602008000790D1/de active Active
- 2008-09-25 CA CA2640041A patent/CA2640041C/fr not_active Expired - Fee Related
- 2008-09-25 EC EC2008008771A patent/ECSP088771A/es unknown
- 2008-09-25 ZA ZA200808176A patent/ZA200808176B/en unknown
- 2008-09-25 BR BRPI0803636-5A patent/BRPI0803636A2/pt not_active IP Right Cessation
- 2008-09-25 EA EA200801884A patent/EA014247B1/ru not_active IP Right Cessation
- 2008-09-25 ES ES08290906T patent/ES2342233T3/es active Active
- 2008-09-25 NI NI200800257A patent/NI200800257A/es unknown
- 2008-09-25 PT PT08290906T patent/PT2042497E/pt unknown
- 2008-09-25 JP JP2008245193A patent/JP5016575B2/ja not_active Expired - Fee Related
- 2008-09-25 JO JO2008427A patent/JO2964B1/en active
- 2008-09-25 ME MEP-2010-252A patent/ME01849B/me unknown
- 2008-09-25 RS RSP-2010/0252A patent/RS51356B/en unknown
- 2008-09-26 HN HN2008001490A patent/HN2008001490A/es unknown
2010
- 2010-05-11 HR HR20100260T patent/HRP20100260T1/hr unknown
- 2010-05-17 CY CY20101100439T patent/CY1110036T1/el unknown
2011
- 2011-10-11 US US13/317,114 patent/US20120029210A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2008221618A1 (en)	2009-04-09
PE20090703A1 (es)	2009-06-27
KR20090032009A (ko)	2009-03-31
HN2008001490A (es)	2010-10-08
BRPI0803636A2 (pt)	2009-06-02
MX2008012119A (es)	2009-03-25
TW200920743A (en)	2009-05-16
EP2042497B1 (fr)	2010-03-10
JO2964B1 (en)	2016-03-15
AR068535A1 (es)	2009-11-18
WO2009074741A2 (fr)	2009-06-18
US8063100B2 (en)	2011-11-22
AP2400A (en)	2012-04-30
SI2042497T1 (sl)	2010-06-30
RS51356B (en)	2011-02-28
UY31341A1 (es)	2008-10-31
EA200801884A1 (ru)	2009-04-28
CN101397292A (zh)	2009-04-01
GT200800190A (es)	2010-05-21
CL2008002833A1 (es)	2009-08-07
TWI358408B (en)	2012-02-21
PL2042497T3 (pl)	2010-06-30
NI200800257A (es)	2011-01-12
US20120029210A1 (en)	2012-02-02
WO2009074741A3 (fr)	2009-11-26
PT2042497E (pt)	2010-04-28
CR10292A (es)	2008-11-26
MA30319B1 (fr)	2009-04-01
UA97638C2 (ru)	2012-03-12
FR2921367B1 (fr)	2009-10-30
ZA200808176B (en)	2010-02-24
ES2342233T3 (es)	2010-07-02
CO6110143A1 (es)	2009-12-31
GEP20115191B (en)	2011-03-25
PA8797001A1 (es)	2009-09-17
AU2008221618B2 (en)	2012-02-09
MY144180A (en)	2011-08-15
JP5016575B2 (ja)	2012-09-05
SV2008003033A (es)	2010-01-21
SG151207A1 (en)	2009-04-30
EA014247B1 (ru)	2010-10-29
ME01849B (me)	2011-02-28
NZ571511A (en)	2010-01-29
DE602008000790D1 (de)	2010-04-22
ECSP088771A (es)	2009-02-27
SA08290594B1 (ar)	2011-02-23
ATE460408T1 (de)	2010-03-15
EP2042497A1 (fr)	2009-04-01
US20090082578A1 (en)	2009-03-26
IL194089A (en)	2016-04-21
IL194089A0 (en)	2009-11-18
KR101099995B1 (ko)	2011-12-28
CA2640041C (fr)	2011-03-08
CY1110036T1 (el)	2015-01-14
AP2008004617A0 (en)	2008-10-31
JP2009132676A (ja)	2009-06-18
DK2042497T3 (da)	2010-06-07
FR2921367A1 (fr)	2009-03-27
CA2640041A1 (fr)	2009-03-26

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